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    <name>A0ABR3V0Y0_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">VTJ49DRAFT_6742</name>
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        <name type="scientific">Humicola insolens</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000671">
        <property type="protein sequence ID" value="KAL1835424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="234"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
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            <end position="714"/>
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            <begin position="772"/>
            <end position="802"/>
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            <end position="74"/>
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        <location>
            <begin position="105"/>
            <end position="143"/>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
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        <location>
            <begin position="363"/>
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        <location>
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        <location>
            <begin position="512"/>
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        <location>
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            <begin position="573"/>
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        <location>
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            <end position="634"/>
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        <location>
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        <location>
            <begin position="785"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="842" mass="88610" checksum="B5E6FA2D75D2F23F" modified="2025-10-08" version="1"> </sequence>
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<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1Q8</accession>
    <name>A0ABR3V1Q8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000556">
        <property type="protein sequence ID" value="KAL1835715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
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        <property type="entry name" value="Actin"/>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR33112:SF13">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="Actin"/>
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        <property type="entry name" value="HET"/>
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    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="93"/>
            <end position="268"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="492"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835715.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="957" mass="105132" checksum="0DAF314C97B61FE5" modified="2025-10-08" version="1"> </sequence>
</entry>
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    <accession>A0ABR3V2R2</accession>
    <name>A0ABR3V2R2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
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    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5625</name>
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    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000472">
        <property type="protein sequence ID" value="KAL1836063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="MFS"/>
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    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="489" mass="51987" checksum="D4C874D6E06CA1D7" modified="2025-10-08" version="1">MGFQLSHLYAAPAVNPVTLKARAIPFLNPIDPYGRVFFFSWFGFMIAFWAWYTFPPLLTHTIKNDLQLSSEEVANSNIISICATLLVRLVSGPLCDRYGPRKLFGGLLLVGSIPLGLAPLVRNAAGLYVSRFFIGLIGGVFVPSQVWCMAFFDDNVVGTANGVVGGWGVAGGGMTYLIMPAVYDGLVRSGHVPSQAWRLTFLVPLAMVITTAIALLLLCPDAPTGKWSDRHLRAQDTIIAESTSDSDQTSIVHGSGGTKGQSTRAPPPKENFVTTTPMPTEKESRPPSPTRPHPPSTDTDTHPRASLLSLQTSFHMLSYACTFGSELAINAVLSSYYATTFPSLSQTNAANYAAMFGFLNFITRPLGGAVSDLLYRFASRSQHSKLASSALWCKKGWLTLCTLGAGVMLVIVGRLYEGPGSGKSEGGAVALLALTAVFLQAGNGANFSLLPHVPDPREVGALAGLTGASGNLGGVVFAIVFRFMDGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V389</accession>
    <name>A0ABR3V389_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000525">
        <property type="protein sequence ID" value="KAL1835846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="687" mass="76201" checksum="6FF51E21A187C951" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3E8</accession>
    <name>A0ABR3V3E8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000440">
        <property type="protein sequence ID" value="KAL1836255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="495" mass="53687" checksum="91CFD3928BB2AE5F" modified="2025-10-08" version="1">MGLKNQEGPSAGPDWGPTSPDQMETGPDSSDGPDIDAAELDRLGRQRPAVFPNIAYELFFCASLLVSMFMAEFFISGFNIILPSSFLLPFGRLADIHGAYVVFNAGLIWFAIWSLISGFSTNYQMLIVARALGGLGPAAFLPTSIMLLGKTYRPGPRKNLVFSLWSAFAPIGFFLGIITGGAATEYLSWRCTRSENAHIRMDYWGVVTVVPGLILTTFAITEGGHAPQGWRTPYILVTFLLGILFIAAAVYVEGWVAKQPLLPFDLFKPKYMARLSVALLFAYGTFGIYLFYASFHIGDYMGESALTTAIWFAPMAAGGLVLATIGGFTLHLLPGRVLLILSGCGFFVCTLLFALAPANANFWAYIFPAMIGSTLGVDIAFIVTNVFITTNVARERQGIAGALINSLLFVGISFFLGLADLAVAEDTHRGGTLGHKVAFWFAVACSAVTLIIFATIRLGKAESELTVEEKMRREAAVTRQKPLQKAESEPPQQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4S7</accession>
    <name>A0ABR3V4S7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000368">
        <property type="protein sequence ID" value="KAL1836774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="208" mass="23065" checksum="A7C97DC410D709F6" modified="2025-10-08" version="1">MSCGGPRNQHVTDTKRIDGRVVRSLKSMGIELQKIHVQQAPGTLFTWGYHPIARFFPLGDFKNIFSAILLARQRCKSHRKAQGLPDEDRTSLCSLALVVDRFQSYWDSVAHTEGMERRRNNSTDEKDTSLGDADSLANIDLTHIALLERVKVLDVESDNEMGVLIQHVKAVELSSPDGMDSSDDEKEASSGKCAEMGDKDMDVSNSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5F2</accession>
    <name>A0ABR3V5F2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000341">
        <property type="protein sequence ID" value="KAL1836989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="5">
        <location>
            <begin position="70"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="250" mass="28457" checksum="2F8D3BD541A08C2C" modified="2025-10-08" version="1">MQTAPFHIRQVAPPWAPCCLPAFFKEDPINSANEVPKDIVCSGAPTRWAHKSAPAGVPLVPSPIPFVPDVETFLTLIGRGLKQHASKFPTWESLFTLSSDQLRELGIEPARTRRYLLRWRENFRYGKFGPGGDFKYVENGTADLRVLEVEKSPLVKDRRVVNVPPGKKVDELSPEEMVRPKGYHVERVKAIIGPYALPKGIQFAQVKVTEGMWEDKRGHKVDGGERRREEVRFKRRVAERKALREAQGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5V9</accession>
    <name>A0ABR3V5V9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clock-controlled protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000325">
        <property type="protein sequence ID" value="KAL1837135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="73621" checksum="4CB85A41DB60A2A2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V629</accession>
    <name>A0ABR3V629_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000368">
        <property type="protein sequence ID" value="KAL1836778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="113" mass="13079" checksum="D62C74F91DC804EF" modified="2025-10-08" version="1">MDARIVRALTKLGVPRRKRDVEAELRGLVDMATAIARVMRRRSGEDREVALSRFLAELHKRHRLGRHLPLEHFEQLFVAIAVARYRYRVDRLDAGLLSPRFGLSHTQDTHSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V688</accession>
    <name>A0ABR3V688_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000326">
        <property type="protein sequence ID" value="KAL1837130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="153"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="582" mass="62986" checksum="11A7DF3A694A7C83" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6C9</accession>
    <name>A0ABR3V6C9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000327">
        <property type="protein sequence ID" value="KAL1837122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="11">
        <location>
            <begin position="180"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="324" mass="36382" checksum="8ECDAC253127A1E6" modified="2025-10-08" version="1">MAEVLKDFPELTIDVDGRKEPIMKRTTLIANTSNMPVAAREASIYTGITVAEYFRDQGMNVAMMADSSSRWAEALRELSGRLGEMPADQGYPAYLGAKLASFYERAGKVQTLGSPYREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINTSLSYSKYTAILDKWYEKEYPDFPRLRDRIRQLLSDSEELDQVVQLVGKSALSDPDKITLDLATLIKEDFLQQNGYSDYDQFCPIWKTEWMMKLMVGFHDEAQKAIAQGLAWAKVRDATQELQSQLRSLKFEVPSEGKEKICKKVSFLGSPLIYSHQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Z5</accession>
    <name>A0ABR3V6Z5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000298">
        <property type="protein sequence ID" value="KAL1837400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45584" checksum="74613A62E06E9D33" modified="2025-10-08" version="1">MGTKTAKLRPSHVPALEFPSRFGDDKARKQCLIVMIPGNPGLVAYYEPFLATLRHLLDEKESQPGCRHAFHIHGRNLLGFADEDHEPAFGTLTDGPEGPAAAEPFNLEDQIRGVCEHLCRLNQPAPPGGSDGNDVHHGDRTRPFDEIILMGHSVGAYITVEVFHRHYLARKAQQNRQQLPPSHDALTTLPLKSAILLFPTLTHIARSPRGQVMTFLANHISPYNLNRLVTRPAADLLLFLLDLPFWPAWLRAGIVRRLTGGFPEHAAAATEQFLRQRDAIWQALHMGADEMRKIGEERWEEGMWEGEGDLREVVGEEEKEEENGNVGAAGADDADKKAKFFLFFAEKDHWVADEARAEFVERRRNHEKGRTRVVVDEAGLPHAFCIHHSETVAEKVHAWIQEIAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V764</accession>
    <name>A0ABR3V764_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vps53 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000291">
        <property type="protein sequence ID" value="KAL1837475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="8">
        <location>
            <begin position="610"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="937" mass="103953" checksum="2ADFFC75D07121A9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7H2</accession>
    <name>A0ABR3V7H2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000298">
        <property type="protein sequence ID" value="KAL1837401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="38198" checksum="E9B3E2E108357A9D" modified="2025-10-08" version="1">MWGNKSRLQPSRPPPPFDPFVEAWLESLPLPAVKPSRKELRQWKLTDYHGLGKSVFVTCLILRAASLLIALTVTALTASVVAHRPAVREALERLVPSLVVCPIVALWNIVEFTVAYIVRDGGLSPNFHVVVDSLLFVGVATAMGTLLVDVICGVTDFGAAFSSAGEEIACVCFLVALMVIHSFLLFFFVCNYVETKRRQLQPLVTHRAVVPRFAHAARYGPHARFSGEGIHPPAAHDVFKQGQVTTTIEMDELRVPRRHHHGSGTLSLPLATPGIHETATANSLAADAGTSERAALAQAMSGLWDVGGESSYQHGSPRVGDDEEESAFNIGPATEQAPPLPPSPPLPAKIRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7I4</accession>
    <name>A0ABR3V7I4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000266">
        <property type="protein sequence ID" value="KAL1837749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="71" mass="7907" checksum="76225DB4FDC3C890" modified="2025-10-08" version="1">MLQPLAIGRSPLAVAVRKTPRFPTGPFEDGIDRYQNPRLTGSQISGAFTLIAMQWPLVQQQLWTAILPMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7S7</accession>
    <name>A0ABR3V7S7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000264">
        <property type="protein sequence ID" value="KAL1837772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61894" checksum="B585EC94354EE15F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7T4</accession>
    <name>A0ABR3V7T4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000257">
        <property type="protein sequence ID" value="KAL1837863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="563"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="573"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="734" mass="81942" checksum="AF090A8D1E0A08E8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7U9</accession>
    <name>A0ABR3V7U9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000275">
        <property type="protein sequence ID" value="KAL1837647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21759" checksum="472278E53847DAFF" modified="2025-10-08" version="1">MEEHTITILLLGDEKCGKSTFLSRISQGRHNLNGHTTITLLRDMDQPFIFQVRSRIAQFRFEFYDTASPENWRLLRPDIIILCYDISQRLSLINLQRVWHPEIRTTFTNDTIPILILGLKRDLRSEDDPNGIIYPQEAHRVATELRADRYMECSAVTGELMTLVFDDICSTALKTVTPEGGQSEGGCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7V9</accession>
    <name>A0ABR3V7V9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">sterol 3beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3389</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000262">
        <property type="protein sequence ID" value="KAL1837802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="336"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="506"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="754"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1257"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1411"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1506"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
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            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
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            <begin position="123"/>
            <end position="134"/>
        </location>
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            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <end position="187"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1837802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1528" mass="168780" checksum="386D6C25B0D081F8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8S4</accession>
    <name>A0ABR3V8S4_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">VTJ49DRAFT_2922</name>
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        <name type="scientific">Humicola insolens</name>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="91" mass="9975" checksum="4B5FB0B00E064BB1" modified="2025-10-08" version="1">MFARVAARQSAQTLLRRPQQANLSVMSSLRSFARSFEPHPFQRVPVTVKPAPADFSRLLKRSAGNAVVFFPVAGGLLGWPYIAKTFVDGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V9H6_HUMIN</name>
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            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Humicola insolens</name>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000214">
        <property type="protein sequence ID" value="KAL1838437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF6">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
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    </dbReference>
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        <location>
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            <end position="242"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1838437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="354" mass="36088" checksum="7489326946F45510" modified="2025-10-08" version="1">MAPPSEGLGFAKKTVQSLVARQEYRGGWPLGFTTAECPAEAPVGCQWLKWYNLNCCPPDHFCFGMLQPYCCPTGRAHQDGTDCGPAVKNVPRCADSSWIMYYNSVAKGSYFCCAPGYIGVIPKSGEAGLCEIEGANIPKTQLASVVSQISGTASPTSTVNIPGGASRTAGADPAATTEGDGLAATGGAEPTATGGSNSNSSSSSSSSSSSSTTTTTISTGAIVGFAVGGVALIALIALLLWLHRRSLRKNPPVPPAPATVTTTVFSAGGAGGATGDQYNNNPAVPAVQSQSEIKPGFDFGQATTPVYGVQPSGSPAPGYAWAPPPPPNGPQEVPENVRFSEMEGSTVSGQGQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9L9</accession>
    <name>A0ABR3V9L9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin-specific chaperone D C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000222">
        <property type="protein sequence ID" value="KAL1838315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="363"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="449"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1290" mass="139347" checksum="FF9CE0DAC56D17EC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA15</accession>
    <name>A0ABR3VA15_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000199">
        <property type="protein sequence ID" value="KAL1838688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="185"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="450" mass="48351" checksum="A0EE79B94A9FC98D" modified="2025-10-08" version="1">MTPPSAPQTAQAAAKAAVSFTAARAPFRPRQHFDVSSDIPRSFFLGHHYAGLARMKQTLATVGLIIECRDFRVPITSWNPLLEQSLAPSNNNNNPSDRQRIIVYTHRDLGPDDRIPGARNGRRGGGTISDLTARHLRDFHLRKGHAAEVLFTSAAGNSGTSGAGPLLAAIKDVARARDSLTGLRCLVVGMPNAGKSTLLNALRRRGMGQNVAKVAKTGAQPGVTRKLSSPVRIVPGEDSAAAAAASAAGHGEDLHGMGEGVFLVDTPGVFIPYITDPEKMLKLALVGCVRDGILPREILADYLLYQLNRVRDFGISSNSHDTDTDTDSPPPEEQDQQRPPLYISRLNLPGPTNDVTEFLTAVAKRFGKLSKGGLPDLDAAAEWVVQEFRRGGLGKVLMDDVTPETLSQAAEELARMATGEDGAPMSLSQARKREKEARKARRLARGGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA61</accession>
    <name>A0ABR3VA61_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000204">
        <property type="protein sequence ID" value="KAL1838609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9574" checksum="BB867DEF833DA18A" modified="2025-10-08" version="1">MPQEVSDIKKFIEICRRKDASSARIKKNRKTQQIKFKVRCQRFLYTLVLKDSDKAEKLKQSLPPNLQIKDVPKKNKQGKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAF2</accession>
    <name>A0ABR3VAF2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000191">
        <property type="protein sequence ID" value="KAL1838823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="554"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114212" checksum="C3D743A8281442F0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAR8</accession>
    <name>A0ABR3VAR8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000201">
        <property type="protein sequence ID" value="KAL1838652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="51"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="574" mass="63510" checksum="2498490BE9143F6D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAX6</accession>
    <name>A0ABR3VAX6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047168755" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="17964" checksum="463E52C4D5CE3201" modified="2025-10-08" version="1">MKSILATTLLASLAMAANPIFNETPYDECNACLDDALTKCKGDLETTEFAHCMCDIAPNMADGYKAYIDCWVDCTFMDQKQSNSIDEVANALAHDHASYCVRFLPDEWCNSFDLDDDTKEKYCGGTNSSSGNNDAAGSSTDSGSPNAAALTGVPAWLMAVGLGMAAANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAZ0</accession>
    <name>A0ABR3VAZ0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000222">
        <property type="protein sequence ID" value="KAL1838323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="150" mass="16588" checksum="6927725E833DCED3" modified="2025-10-08" version="1">MSYVTRRALSTLIPPKVGPERAADWSRWMLTMIIRWPRRRYVAECHGGPDPLRLPSYPAADDFPEAQSLTPNVDRGGGGSKKAKLPGRHADRNTQAIGAAPDAVRMQRVVSFYEKLPRGPAPEVKAGGILGRYQAKHFGKNPTAKRTWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB02</accession>
    <name>A0ABR3VB02_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000184">
        <property type="protein sequence ID" value="KAL1838947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14369">
        <property type="entry name" value="CUE_VPS9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041804">
        <property type="entry name" value="Vps9_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="6">
        <location>
            <begin position="413"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="5">
        <location>
            <begin position="736"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1298" mass="140993" checksum="352ED8D48744EC26" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB63</accession>
    <name>A0ABR3VB63_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000203">
        <property type="protein sequence ID" value="KAL1838631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046893400" description="Acid phosphatase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="50834" checksum="AF26E805F955A4AF" modified="2025-10-08" version="1">MHSVRTSILALIGLAAVAVADTVHGVVVFARHGDRTTKHFSSQVLTPLGARQLFQVGSDYRARYLSSASSHRINSISESMYVPGQIDASAPDEAVLLSTATSFLQGLYPPIGDDQAGISVQQLANGSSVTTPLEGYQYVTLHGVSSDSPDAIWMKGDDNCPALNAAAASFSNSAEYASRFAATRDFYASLHPFVSSVYPSPSSMTYAHAYDIFDLLNVARLHNASSKVAEELTAAQLFQLRTLADSAEFARNYNASQPDRSIHARTLIGAVLQRLTNTAASVTGGASAPKFSLLAGSYDTFLAFFGVTRLTETSTDFYGLPEYASTMAFELFSPGDATLSSEEDLRVRFLFRNGTEGSLTEFPLFGKGEKDLSWTEFAGAMKELAIDSAADWCSACRSEAVFCAAYRGRDGVDVAGAGQEVGVSRGSWIAALVVMSVAVVGNLAWAGAWLVQRRGSKRAVGERVRKETDFDEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB70</accession>
    <name>A0ABR3VB70_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000183">
        <property type="protein sequence ID" value="KAL1838957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="426"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="495" mass="51087" checksum="A123A22C0826A9A1" modified="2025-10-08" version="1">MAPTKKGKASGPQKKSAAATKKPTATSEPPAQLMDLIESFLSEHDFADAHRAFTQQREKKGWKKTGKVSTSDNPSLVTVFQAWETSLSSAAAGKSTKTAAEKATKVSTSSDSDSDSDSSSSSSSSDSDSSDSESEGGDVEMKDAPATDDSSSSESSSSSESDSSSSSESSSDSSSDSDSSSDSDSSSESESEDEKKPAAAAKAAPNPLKRKAASSSSSSSGSDSDSSSDEEAPVAKKQKVAAAPAESSSSSDSSSDSSDSSDSSDSETEATKKPAAKKVKKEDSSSESSSSSDSSDSSSSESSSESSSDSSSDSDSDSSSSDSESEDEAEQAAKVPLPESGSDSDSSDSDSDSEDDKDKAKDTKIKSESPAGAGSDTSATLGKSDSPKIFPVNEFAPLPPDPSTVKTNNRGKNNNGNNNKKQPTQPFSRVNKNVQVDPRLASNAFQGHDWGRKAHEDLIVTRGKGFTKEKNKKKRGSYRGGRIDTNAVGSIKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBI9</accession>
    <name>A0ABR3VBI9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase lambda</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_1838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000173">
        <property type="protein sequence ID" value="KAL1839142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="159"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="369"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1839142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="814" mass="90065" checksum="97D6338E67EC23F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBM2</accession>
    <name>A0ABR3VBM2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000169">
        <property type="protein sequence ID" value="KAL1839210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="825" mass="91816" checksum="215C010B4E9035E7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBS7</accession>
    <name>A0ABR3VBS7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000164">
        <property type="protein sequence ID" value="KAL1839310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="9">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="215"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="490" mass="54515" checksum="3C780E025354BA19" modified="2025-10-08" version="1">MAPTYNIAMVSDFFFPQPGGVESHIYQLSSKLRDRGHKVIIITHAYKGRTGVRYLTNGLKVYHVPFFVLYRSASFPTVFSFFPVFRNIVLRERIDIVHGHASLSSLCHEAILHARTMGLRTVYTDHSLFGFADAASIFANKLLKFSLSDVDHVICVSHTCKENTVLRASLDPLMVSVIPNAVVAENFKPLDPSELSSDAFSRRHPPPVRPPGPHDMITIVVISRLFYNKGTDLLTAAIPRILENHPNTRFIIAGDGPKAIDLEQMIEQNVLQDRVEMLGPIRHEEVRDVMVRGHIYLHPSLTEAFGTVIVEAASCGLYVVCTQVGGIPEVLPSHMTVFAKPEENDLVAATGRAIAALRANKVRTELFHEQVKSMYSWTDVAMRTERVYNGISGAISEAEFYGYDAANGAGSWSATRGRSGVQSFALIDRLKRYYGCGIWAGKLFCLCVIVDYLIFLALELLFPRDKIDVCPDWPKKARKSTGAVAGFSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBW0</accession>
    <name>A0ABR3VBW0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000163">
        <property type="protein sequence ID" value="KAL1839340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="389"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1657"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1790"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1303"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1462"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1620"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1738"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1868"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1626"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1752"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1768"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1784"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1874"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2142" mass="232869" checksum="290F113E5D39DC7A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC31</accession>
    <name>A0ABR3VC31_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000163">
        <property type="protein sequence ID" value="KAL1839337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="258"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="775"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1351"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1421"/>
            <end position="1430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1430" mass="157837" checksum="DD7C7396AE191686" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC58</accession>
    <name>A0ABR3VC58_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000161">
        <property type="protein sequence ID" value="KAL1839367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="505" mass="55651" checksum="E14E18EA0A0DDDC5" modified="2025-10-08" version="1">MSPHITDEGVQYPETMNGTHNHDSDAEVVPQLVNSAGLNGSSNGVPANTSPKSPYLKAADPNAVLDLVCVGFGPASVAIAVALHDSLEARKLSEAPKVLFLEKQPRFAWHAGMLLPGAKMQISFVKDLASLRDPRSNFTFLNYLHKNNRLIDFINLNTFLPARAEFEDYLRWCAEHFNDVVRYQTEVVSIAPVQEDGPAKIFAVTSRNVKTCVTTTYQARNVVVAVGGQASVPKLFPAHHPRIIHSSQYAQVVPEILSDRSAPYRVAVIGAGQSAAEIFSNVQALYRNSKTYMVMRSEFLRPSDDSPFINSIFNPDFIDHLYPKSSSYRSSLIADAKATNYGVVRLELIEHLFEIMYHQKRTLGPDETQWPHRILTGREVLSVQDKGDKIGLKVAKIPTAGTADGPLLGEEDLEADIVICATGYQRKAHVDMLKDAWHLLPELAPAEAQTQRNDRWVVETGEAESRSSRVMEVSRDYSVRFAPGAVAAGSGIWLQGCCEATHGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCV9</accession>
    <name>A0ABR3VCV9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000155">
        <property type="protein sequence ID" value="KAL1839470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="259"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="401" mass="44114" checksum="6186B1BA44033A84" modified="2025-10-08" version="1">MVSPTSATTTTSNGSMSVASIVSPVPPATDPRRYDRPTSLESVPSSAGFVNGDVPESLSRRESVDSRINQGFHDMRLGNSPYASHNHSTTSIHATLQQQRNPRPGLDTLSVHRISNGYQPSVERNPEPQQNHPKAMRIAPAITGPATSQIARAAEPTKGQAWAFPEEEIHRMPSAAAGSLIDSRRSSIAESFASSQYTDQARLPPGQRRLDDGTFQRVPNASEYSTVHHHTLQHKAIGDLRNEESSNHTGTQPYSRTPELRVSHKLAERKRRTEMKELFDTLRDLMPQERGTKASKWEILTKAITEHQRQNEMIRQLQSVNQAQQHEIDALRREIERLNAAQQARPPPDPYAQDRFGGPRPPELPPLRSLQPPVGPPGPPGPPSGPDSMTGVQKCSDGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD28</accession>
    <name>A0ABR3VD28_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">XPA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000143">
        <property type="protein sequence ID" value="KAL1839720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="5">
        <location>
            <begin position="228"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="391" mass="43955" checksum="A7EF23C9FCC378D6" modified="2025-10-08" version="1">MNRSGTPPRRPPPSQRQPSPPTPEATRRLEESRLRAKAVQREAEKQQSSGTSSTPATSATAANDIQPASAAGRKRPYASISRTDVPATSRDARAAQSKDGTSDNLRPISKKFSKYVDYNFSAMTDTKGGFLSTEDDPWNKSMSTGEVGKPAGEQKPAHMTQAEWERMQLIKKLQRSKSGPYAPPLSILADEKTQKRCRECSSIDIDFLWEEVFGCAVCNTCKEKYPEKYSLLTKTECKEDYLLTDPELKDPELLPHLSKPNPHKSHWHDMMLFLRYQVEDYAFNHKWGSPEALDAEFERREADKKRRKEAKFKEKLLDLKRKTRTEAFRRNNARAASGGDGSAPGRATKFGDAIGGNGKHVHEWGRTVENADGMTVKTCLTCNMEVEELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDA1</accession>
    <name>A0ABR3VDA1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045752647" evidence="2">
        <location>
            <begin position="23"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="279" mass="29109" checksum="4A44FA5EA446D795" modified="2025-10-08" version="1">MKYPVRSAALTALCAFPFAATAYQTVEDSPNMLDDCAACPTMYNVFFECQQLVGDARPCVCPDSVNTEWYAYIDACQGCLRLSSRDDFWTYFTTTSFALLHSCRAPSVPITADGHSLCTTSGKSESCVSLRDTSQGASWASYEHLEYPQNNKNVSLSLNLAVAKPALTTSTTAASSTTSTPATTAESTSKDTASTTSASEADATGTDSEGTTTTFSTILSNTPSSTSTPTSGTDSEETTSAADAQNTTPVIVPGAAARFGGSSMGWALGMVMVAAFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDA9</accession>
    <name>A0ABR3VDA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000153">
        <property type="protein sequence ID" value="KAL1839507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045319870" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="149"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="643" mass="71080" checksum="9BCDC2F1559D100E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDD4</accession>
    <name>A0ABR3VDD4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000138">
        <property type="protein sequence ID" value="KAL1839840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046224390" description="Nucleotide exchange factor SIL1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="48639" checksum="1B90D172E7CC77A2" modified="2025-10-08" version="1">MAKIRLKTLPISLVALIGLMAWGSSASSSDSSSSASPSESPSAEVELICHTDNPADCYPKVFQPTDEFQVVHPDQDLPPGLHVRLNINTGLREAKINVPDEHRPDLEGLPVDSSVVVVEPNPPSADDQPKIPPNAPAYDPAGKIKEPKSAGTGEASAFYKSLTILKKGLDVDGALEMLEEISHDIYYGLKIAEDYDTVHELFCLSTTPSTTTSNDGSDNDEATLRRARLASLTLASTVQNHPKALREIEGHWPQLSSSLCPASNRSPRTTTLGAAIFSLLPPADASDLPNPSLTKIRVALLTGLLKSPTLRAQFLAASPTGGAAHILRILTSPTPSSLSEDDAAAWAGTQRRAAQLLTDTFLDADMGAALGEWPSSSKAQLSAKECAVLHEAGDAGHGREECLDWHVERLRKEFKKDDDHWSHEFGKKLAEARKSKKPLKPKKKKGQGKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDS4</accession>
    <name>A0ABR3VDS4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000135">
        <property type="protein sequence ID" value="KAL1839916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="612"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="691"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="810"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="878"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="816"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1085"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120438" checksum="789D1E373490589F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDU7</accession>
    <name>A0ABR3VDU7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_1519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000158">
        <property type="protein sequence ID" value="KAL1839418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="110"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="237" mass="24783" checksum="FC324099D8FB8763" modified="2025-10-08" version="1">MTPPADAAQPAASTITNPTVLTSSTELASTTTTAPVQDASGGDSATTAAGSSELASIKTKLLASLGHFADFPIPGIKFIDILPLFRDPAVHVDLLRALELQIQKEFGADSAHKPDIIVGLDARGFLFGPSLALRLDAGFVPVRKKGKMPGPCVTAAYEKEYGTDYFQMQEGAIKPGQKVLVVDDIIATGGSAAAAASLVKQLGGELIGYLFILEIPFLNGRSKLGDVKMVTLLETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE47</accession>
    <name>A0ABR3VE47_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_1166</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="130"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="455"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="750"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="774"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1839792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="791" mass="88780" checksum="47936F470EC71BC3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEK7</accession>
    <name>A0ABR3VEK7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="233"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="355" mass="38420" checksum="B23E9B2EE4146102" modified="2025-10-08" version="1">MDGSASTASSLGSSGSAYPTPALLDETMWSYFCAGRSASGLHANAMGSLEPWQTLESTSTLEGRDLQVLPMTPGSWTYQATELASPPISTVGLQPNLVFSNLARPTRLQLSWSSESSPTTTAAFPAITTSPQDNPDDPTLKRIKTEPQTQTQPRRPNIQLRTAARKKRKSSRSLPSATTTSPASCSPAQTVSPPSSSSPRAAEDDDNDDDGNNTDNANDNYNEDDGLTPEARRARHNHNRVEKHYRRRLNVQFARLLDVLMLPVPPARAPSIESATTVKRGRGGGDGLGVVDVGGGRGDDGIDEKRISKAEVLELAARRIRELEKDKETLVRERKELVRNIEVLMMAGTVGRGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEL0</accession>
    <name>A0ABR3VEL0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000144">
        <property type="protein sequence ID" value="KAL1839703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="207" mass="23411" checksum="DC17887BE2FE95EE" modified="2025-10-08" version="1">MSSCKKQYDPTIEDSYRKQAVIDNQACMLEVLDTAGQEEYTALRDQWIRDGEGFILVYSISSRQSFTRIKRFHNQIQRVKESTASSPSYPGSPISAANPVQVPIMLVGNKSDRIADREVSTQEGHALARELGCEFVEASAKNYINVDKAFYDVVRLLRKQRQQAAQPLSPTGSSRYDSRRTDSSILSEKSRGRRERGERRRGGCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEM4</accession>
    <name>A0ABR3VEM4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000143">
        <property type="protein sequence ID" value="KAL1839718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="191" mass="20966" checksum="D425DAF53EF3F474" modified="2025-10-08" version="1">MALSPQVTNLIIILGMMQVAKKIHFEDPDVLNMCRAAYIASNLIIFSIYLYIKTVIDKKKDMTTLKYVEPAPMGSSEEGKLVTTTVHAYDVGQLKNLMRAQGMGILMMAFMHLYMKYTNPLLIQSIIPLKGALEANLTKIHIWGQPAIGDLKRPFKQGGGLMSGLQSGPAQADKKAVEAAERAGRGGVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEY8</accession>
    <name>A0ABR3VEY8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000118">
        <property type="protein sequence ID" value="KAL1840319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="83508" checksum="6101EE011078B026" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF10</accession>
    <name>A0ABR3VF10_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alternative oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000115">
        <property type="protein sequence ID" value="KAL1840387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51999" checksum="1C4F185416A64A91" modified="2025-10-08" version="1">MGPRLATSPGFLARPRGVLLTVSLITLLNIWLTRLPKMCLHGEPSPALTHLSSPPQPPIDLSHADAPFIPWPLSRVCHETTTWNPHLIFLCDNNSGGIGNIRNYILTCLRYAIDAGAGGLVMPTISTRSEKNLADLHGQPVKGFDYFFDEAHFRKSLREACPQVTVYESLEHVPNAPSRPEMLTPRNLGRRGGCDNRELNKHTGLFGARVQAWLNKTAAESEVRLVYPATRERPRVVRLNWGVQWDWPVFRDGPEFVASFGGLLRFRGDILELGMRTVGYMREFAARHGNGKRRFAGFHLRTENDALSRWPKFDEQSGAYLERAGKGGMGFAAAYLATGNSTEARKFTDVAREKHGMAVVTKQELLREYGAARDDLARLEALTWDQQALVDFAVLLECDYFFGVSPSSFSINVAGKRHLKEEGLYTRPWRIGGEGDGRSWLAGHYEHYWEDWLFMFESLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF50</accession>
    <name>A0ABR3VF50_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047012616" evidence="7">
        <location>
            <begin position="28"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="438" mass="45603" checksum="89E0AC9444A1984A" modified="2025-10-08" version="1">MSVLRRLGRPRAAVVLLLATLAVSAWALNTAKPEDPSGATTLASVDNISLGELDEQLQHCPIITSLSAAKAHKLASQPPSAMSRLFALLFPSSHPGINALLATLYISGPPNFLLALCPPNIDPASLSVMVAFAVGGLLGDTLFHLLPEIFLGEDEDPERVKVVLVEPNRNLLLGVAILVGFMVFVAMDKGLRIATGGMGHEHSHSHSHEHGHGETEGNGVVKAATGVEGKDAARRRKGGADAAEVSSPVVVEEKEHDKNPSAKLGGLLNMIADFTHNITDGLAMSASFYASPAIGATTTMAVFFHEIPHEVGDFALLVQAGFSKRQAMGAQFVTAVGALLGTLIGIAVQEFGGGAGGSTASGGGTSMGMRDGLWGTSLTWGDMLLPFTAGTFLYVGTVAVIPELLETGPNRGAELRKTLVQFAAIALGAGIMLYISWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF62</accession>
    <name>A0ABR3VF62_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000135">
        <property type="protein sequence ID" value="KAL1839913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="612" mass="66558" checksum="D91367CDBD54588F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFD4</accession>
    <name>A0ABR3VFD4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="572" mass="63183" checksum="B97A552991A3C929" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFK8</accession>
    <name>A0ABR3VFK8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_439</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="15">
        <location>
            <begin position="736"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1840487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="815" mass="87436" checksum="16DF6B1B1E21C11D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFQ9</accession>
    <name>A0ABR3VFQ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_644</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1840266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="172" mass="19059" checksum="EDD15E6C45ECCD7B" modified="2025-10-08" version="1">MFSSLQNPRQAAAQLLNFGLILSTAFMMWKGLSVVTDSPSPIVVVLSGSMEPAFQRGDLLLLWNRNLFEETNVGEVVVYNVKGKDIPIVHRIVRKFGSGPDAKLLTKGDNNAADDTELYARGQDYLTRKDIVGSVVAYMPFVGYVTIMLSEHPWLKTVMLGIMGLVVVLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG17</accession>
    <name>A0ABR3VG17_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="386" mass="42780" checksum="2BFC0EBF1D552D23" modified="2025-10-08" version="1">MADEPPTKRKCLGADCENDASSLQCPKCLTLGIKDSFFCSQECFKKNWATHKNLHKTETKTGFYNPFPKFNFTGPLRPVYPLSPRREVPKSIPHPDYAEDGIPKSGRSLVRTNKITQLDAKGQEAMRKVCRLAREVLDIAAAAIRPGITTDEIDKIVHEACIERNAYPSPLNYNHFPKSVCTSVNEVICHGIPDQRVLLDGDIINLDVTLYHEGYHGDLNETYYVGDRAKADPDSVRVVETARECLEEAIKLVKPGTLFREFGNVIEAHAKSRGCSVIRTYVGHGINTIFHCPPNIPHYAKNKAVGECKPGMTFTIEPMIALGKYRDVTWPDNWTSTTIDGKRTAQFEHTLLVTETGVEVLTARKADSPGGPIPMPTPAAETNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG81</accession>
    <name>A0ABR3VG81_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000119">
        <property type="protein sequence ID" value="KAL1840303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="87"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="490" mass="54327" checksum="183EE572B1561F8E" modified="2025-10-08" version="1">MPDSDSPSNGFGHRKFSINRNTGVPRPARRFSMGQNEASSKVHRQFRAAHEGHLPHAGLDASRASTGVVWCTERAAEYGFFEEPEKWANLGQGAPEADDDIEGCFKRPTTIDISSASREYGPTAGIKPLREAVARLYNEMHRKGKPSQYTWENVAIVPGGRAGLIRIAAVLNNAYVGFFIPDYTAYNEMLSLFKNFAAIPVPLSEEDGYHIHPDKIAEEISRGTGVILTSNPRNPTGRLVQNPELAEIQNLCRGRATLVSDEFYSGYNYTSGCDGSTVSAAENVVDVDEDDVLIIDGLTKRFRLPGWRVAWILGPKEFIKAIGSCGSYLDGGTNVPFQEAAIPMLDPTLVRQEMAALQRHFRDKRDYVVSRLRSMGFVIRHVPDSTFYLWLNLEGLPAPISDGLNFFQACLDEKVIVVPGIFFDLNPARRRDLFDSPCHHFVRFSYGPKMEVLKMGCDGIERVINKFKKLAAQGASATTNGTKTETEAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH26</accession>
    <name>A0ABR3VH26_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000106">
        <property type="protein sequence ID" value="KAL1840603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="357" mass="40086" checksum="5ECCD04C0617DC3D" modified="2025-10-08" version="1">MLSRLYMLDGAYQSVVSFFIPYLFVAITTSAAGNGMDVAERLRLGAYIAHPAIFTINSYILINTYRWDWLMILVVVISDIFIFFWTGVWTAFTYAAGFYKAAPQIYAELTFWMCLIVTPTICLLPRIVVKCVQKQRFPYDVDIIREQAKQGEFAEADAAAQAAIAGIVDGSGEGASATSSSSSTGKHSGRGRHRPSRHAQYASVDEDRRPIYPPSIATHNTRTQNASDGTTYIMQSRESAELQQRQREEWEQELERERERSAAAAALEGNGQQQPVERTVTRPSIDRARPSYDRVRMSMDRVRPSFEASADFTSAARLSRIESTHSTQEHPGGQRRFNLTTVRKRGLSAFSKKSIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH43</accession>
    <name>A0ABR3VH43_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000091">
        <property type="protein sequence ID" value="KAL1840988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="194" mass="22723" checksum="BF7AE2AD720FFDD7" modified="2025-10-08" version="1">MAYSKTHPGRDITLDWDTTTDVVILNYPVTPAPKVIITLPPDDPIVRDGLVDGLEVRFRLEEYYEDRNMSQYLDGRDEVEREDTVAVDGTLTIVFVGEELRIRKLGNFNLFAEFPCPLEYPRRQHYLARIQLLRERDDGEYELAPRSVLRGHPFVMGISVQENSRGKQEVEFAWDDLRITRPGSYMFRVTFYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH55</accession>
    <name>A0ABR3VH55_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF1">
        <property type="entry name" value="COLD TOLERANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="361" mass="38162" checksum="E22EF042F64DEFBB" modified="2025-10-08" version="1">MSRLLILDFDGTITQHDTLDALVSLAITHSTSSPSPSSQPQSALEPGNEGKTQQTRTKEALTTVWQTIVADYITACEAHRGAYRPAADQRTSIEEELAFLESWEPVERASVARVSAAGFFRGLGGVGREEGEGSDGELDGAQGGGMLVKLGRGAALAVSGTGSGSDPGSSGEPVTVELRKGFGEFMERVGTAGWEVAVVSVNWSDEFIRGVVQAGCDKYRGGDDSSSSSSTSSSDSWPGKVLANRVRFPDGQILGPRELGGEPLVTAGDKLRAMKSLVKGTGSEKGTPKVVYIGDSTTDLTCLVEADLGIVIAPDTESKLLKTMDRVQLQVPHVEEAARGSKLAWARDFEEVLRSGVMDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHD8</accession>
    <name>A0ABR3VHD8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045754410" evidence="3">
        <location>
            <begin position="29"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="559" mass="59143" checksum="7091260A3F137FDC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI97</accession>
    <name>A0ABR3VI97_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="40804" checksum="98C5D52279340860" modified="2025-10-08" version="1">MRRVPASYLVPVPRRPQIASRYANLHVCLSPSTPGEPEGQPHCLNSTLSIDISTSWTTKDVVIPTIHKPGPAKSNVVLWTDGAAGVFYSWGGRFPHGRNVTKTSSPELWKASEEGAWVSTPEAGFLIGGMNHGLMSSGYPGSATPVVGMLELDFKTTTVTNGTGGFSPFGDGSLIYGFAAYVPTFGANGLVMLFGGYATEPSGIADFSRSYGKPYDLETLTFFDPVSKKTYSQKATGTIPTTSRGDFCTAGFPTPDGGFDIFLSGGSGNNVNWNAHDAYILSLPGFFWTRVSDGSGTQMRRGRSCVRVGSRQVLVIGGYNGNATHPDPAPNGLPLFGMSTLTWKDAYDADAGEYDRAQSISDWYSSGELEKVQWSAVAPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIC5</accession>
    <name>A0ABR3VIC5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047443836" evidence="1">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="127" mass="13283" checksum="4B123C512CD49B33" modified="2025-10-08" version="1">MRVATAIVFAASLAAPVLGAATKWYSDTECKDFIDKKVYNGASEGDAVIPMEGVGSIMVDSIMDPWFAYNGAGGDGCAGEQLGRLPNKKCVKIFRKEGDEGYGIMCTRLCSGGGIFGTGECAPKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VII3</accession>
    <name>A0ABR3VII3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="4">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_6989</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 23">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000073">
        <property type="protein sequence ID" value="KAL1841498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 18" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="20">
        <location>
            <begin position="98"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1841498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="324" mass="35584" checksum="A9621C6BBD94B30F" modified="2025-10-08" version="1">MLARSCLRSARAFAGLRNGAVHVSKRAASSSSSGANAESPLRLNIAAAAATAVAASSIAWYYHLYGPTADAATPAEEGLHPTKYPWVHQQWFKTFDHQALRRGFQVYREVCASCHSLSRVPYRALVGTILTLDEAKALAEENEYDSEPNEQGEIEKRPGKLSDYLPAPYKNEEAARFANNGALPPDLSLIVKGRHGGCDYIFSLLTGYPDEPPAGAQVGAGLNFNPYFPGTGIAMARVLFDGLVDYEDGTPATTSQMAKDVTEFLNWAAEPEMDDRKRMGMKVLVVTSVLFALSVWVKRYKWAWLKSRKIVYDPPKTPNTPPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIP5</accession>
    <name>A0ABR3VIP5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="333" mass="38157" checksum="34ED5B4C451E3908" modified="2025-10-08" version="1">MADTIEESNVSYDELMDLENEFEDVETEIIRKQYEMSKPLYAKRAELVSQIKTFWPLVFEAAPMDIDEYIQPSDSALLLSSLKSLSVTRFELDADPAKGDPRSFAIRFEFDENDHFEDKVLEKKFWWRASKDGFRGYVSEPVEIRWKAGKDLTDGLLSLAKAVYDEQKGKPRPAASGNAKDKKKEKEPLTDKQKALKEKIDQTGMGGVSFFAWFGYIGEYITAEESREALAEEAEERRKRKAGEAVPKKDDEDEDMEDAEDSDDEDDDDDLDIFPAGDAVAMAIADDLWPNAIKYFVQAQEQDILSEIDEEFDDEDDEDDEEEEAPKRKKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIW6</accession>
    <name>A0ABR3VIW6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="554" mass="59567" checksum="891178BDFDEF9C4A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIX2</accession>
    <name>A0ABR3VIX2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-protein ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16616">
        <property type="entry name" value="mRING-HC-C4C4_Asi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="630"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1027" mass="112001" checksum="CD391346F876352A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ59</accession>
    <name>A0ABR3VJ59_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="44690" checksum="1A24F1C211909120" modified="2025-10-08" version="1">MSELENTGAPGVAGDPTMLSAAAQAQLKKVKKQKVLLMGKSGSGKSSMRSIIFSNYLARDTRRLGATIDIDLSHVKFLGNLTLNLWDCGGQEAFMENYLSQQRAHVFSNVGVLIYVFDIESRDVERDLATYVNIVSALVQYSRDARLFVLIHKMDLIQPMLREDVFDQRAALVRRKTAEAEAVMRKHLQQQQQQQQQQQQPPPQSQPSPSPTPEPSIHLQLFATSIWDQSLYKAWASIIHDLVPNLSVIETQLASLGAAIDADEILLFERTSFLVVSRWTSREGERNPYGDRFERMSNILKSWKHTCSKYTGTPRNAEQFSDFEYKMGATFSMFATKFTTNTYILVCMPPGEARFNSAKLNVAAARSWFKFLDGPVVQAQQPQATGYPGYGEGSNGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJC4</accession>
    <name>A0ABR3VJC4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="240"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="683" mass="75817" checksum="F672007E1B4EF7D5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJK0</accession>
    <name>A0ABR3VJK0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000064">
        <property type="protein sequence ID" value="KAL1841772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42258" checksum="6F63917BFFA31DD5" modified="2025-10-08" version="1">MIIQQDGASSPLATKFQFLHHVTSRRPRVYVLVGIAFLLVTVAVWTYGGLATGIDFITSLPHPADLLHHTTTNSTEAPTDNDWRHSKQRPVNAVGIPNKIWQILLPKKSSSEPFVANPKSLEDTPTWLALNPDYTYTLVGQKGGDEFVENNFGHEPRIVEAYRKMPNVGMKSDLLRYLLLWAQGGVYTDTDTVALKPIDVWVPEEMRDEVAVVVGIEFDRRDGPPWADILHWVQFCQWTIAAAPGHPVFGKMVHRVLDALDDLSAAHGVPIDQLKPSSFEVMNSTGPAAWSEVVFKQLQEYDTSLKEHKDLSFMTEPKLVGNILILTIDGFGMGQPHSNSTNDGTIPEAALVKHLFKGGWRGDAKRRRWIYEDYDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJX6</accession>
    <name>A0ABR3VJX6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18033" checksum="F2D88BE95E7E48EB" modified="2025-10-08" version="1">MAHLKLLKQRTRADYPYIREYRTRWSDNDMYNHMNNSIYNFLYDSVINTYLIENCGLRPASSPQYGMVVHSHNDYFSSISFPACAELALRVNRIGQSSVTYEIALFEKGQPAVKSVGEFVQVFVDRETGRPNPKGMCDKMRRGLEQLLVPQARSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJX8</accession>
    <name>A0ABR3VJX8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000053">
        <property type="protein sequence ID" value="KAL1842119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050334">
        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="33"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="364"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1016" mass="111295" checksum="6E058E69C9280B0E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJY2</accession>
    <name>A0ABR3VJY2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="164" mass="18376" checksum="9932BAEFB710AC1A" modified="2025-10-08" version="1">MTQFPSPQFDLSLHLLSPSQSNPGPNSTSDLTEAVAKLRVLNAQLEGAQYARFWATLDSDDIYADLTTDIAGFEETIRLRIAQLVSQAYREVQVEVLEAWLGLDDADAVKKFATETCRWKVSEDGTTVLIPPNPDNEAKKTEIREEVSVDMFSRVIRRAWEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK80</accession>
    <name>A0ABR3VK80_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="396"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="491" mass="53284" checksum="1B886BE7764F395E" modified="2025-10-08" version="1">MSDTPPQPDGAVDTNPVTESTDAVNDAVADSTGDATGEAVTDAVTDTVPETSTDTAANAPEAVAEATTDAPKPTVPAEPPQPFSWLQPHPIFVILLVGPDETPFGIQKDFLCSKSSYFQKHFAEQPEQGLENIVRLPDTPVEVFAYAQHYLYTGQVFPNVNNLPSYEVLIGLWKLGHTLGIDGLCDAALDAMTECRRLTQTIPATPLLVRVWSDTPEGSSIRKLLLSWAAEYMRSSESRAEFARSLPQEVLSELVVAMSSLEESPAPPPPSQNMEETAAAAVAIASAASAAAQRRSAPSEPDGTNNSEADVGRPAKRRRGSDAGTANTNGGTHTTVGRKRGSMTGAKPGPKPGSKRRTSAAVSGQQFSANQKLNFCADLLTRMLSGPGFWTRVVGPFRDPVDPERDGVPDYFDVIKKPMDLSTMKAKMDRHEYADETEFLADMNQIFTNCYTYWRESDPMWAACEKLQKSFEDKFAQMNKWIAKMEGEEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKD6</accession>
    <name>A0ABR3VKD6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020301">
        <property type="entry name" value="Mrx7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10906">
        <property type="entry name" value="Mrx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="97" mass="10855" checksum="2419B5336F7705E4" modified="2025-10-08" version="1">MPVSPRVQDGMGTTIMGCLSEDLIVAHILRSPTFHRGVRRIHRTVEDLRYGRDPSEPLRQGEATAEPNRAGGFFKHFIEELKNQARGKPSDPPPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKY4</accession>
    <name>A0ABR3VKY4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="285" mass="29703" checksum="E2EEEF1AAEC452E7" modified="2025-10-08" version="1">MSPSKPREWPAQESPVTSSDASATQDIPTFIWPQHRPRTEEVSIASSLTTINAAAAGQDIPTLIWARAEEVSSASSTTTTPAETTDDARESVSSDIQATIGVTVFAGCVSIAVGGWFLRKHMLARKKRKQEAEEAEAAAAGTANDETPNPSDDFDDALGKRPELEGSPAAVELSGVVALQELEVVEKPVELGGTPRAELETCWNDASTWSALQQSSPISPTIPDSSIARSPTVVASPSSSSSSATVAVAGTSAGGFSFSYTNSLRLSPFADHGGALVSPQTSLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL43</accession>
    <name>A0ABR3VL43_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1183"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1194"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1384" mass="150705" checksum="7E8F2E53C6B8B019" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL67</accession>
    <name>A0ABR3VL67_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_4565</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="432"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="690"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1842654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="794" mass="90229" checksum="60F2695FFA8F9983" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLN5</accession>
    <name>A0ABR3VLN5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="311" mass="34395" checksum="4EBB77D5278128E6" modified="2025-10-08" version="1">MATKTYKLNNGLDIPAIGLGTWQSAPGAVRQAVVEALRAGYRLIDCAYCYGNEDEVGQGLADAFSQGIVKREEVFVVTKVWATYTTRCALGLEKSLKSLGLEYVDLLLVHWPLLMNPEGNDDRFPKLPNGERDIIRSHNHVDTWKQMEQLLALGKTKGIGVSNYSKRYLEQLLPHATVIPAVNQIENHPALPQQEIVDLCKEKGIHIMAYSPLGSTGGPMLTAEPVVQVAEKHGAKPAAVLLSYHLARGSTVIAKSVTPERIRENIDTLLELDAEDMQKLNDYSAQLTREGKLQRFVYPPFGVDFGFPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLP8</accession>
    <name>A0ABR3VLP8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="450" mass="49904" checksum="80C47274F81527C2" modified="2025-10-08" version="1">MEDYTGARTLPTHLHHSTGSGLVHNRHYQPRYPLNDSDDDNNVHDNTFHSPHYHHTNTIRRHTAPEVYYPAAYPSLDDDHTNHTNHTTNNSDDAQTKPIPISPRKGSLAIPPRHHYHTRHRPRGYVHADVLAEVECEQRRKNRRDRRGYRPDHDEQDEHDDGEKKEEEEEGWFFDWSPSPAEGSTPQTTPAPAMVDHSAAIPRSATGLQQDGLWLGSGGIEEVVRNGDGDGGGGEGGGGRGYFPLHEEPGMRRKAPHPFYRDAERARRASIQLAATECNRPSGNFYYSSSSSSSSDGIPSLSQPPQPQQQPQKPPRQPTSQAPLSGEQPTDSTISPYIPDDVPLGVVIPTGKYYPTNWEKRHGQPKLRAPVTPKQSTSTPQLSTAQQQPGHEEYSNQPKESSVSLASGLRSHRRGQISPVASFLNRHGPISPQLGPIECPGTVTPISLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLS4</accession>
    <name>A0ABR3VLS4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Synaptobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="42424" checksum="5C1FED4E76378613" modified="2025-10-08" version="1">MARLIHGVAMSPAPRQGDPLTDLSMLLSRLQRTILHADAEREARLRESEFEREKAHANISYARSLLTKLEQDASAIKIHPRRQDIHADLLRKRDLLDQLSDHLNDLAEFAAAAAASGDTSAGGGNGDGDQDTSDGEDILADIIATPSESLDSSARSPDIPPQLPQESQQSHDSSDSAPDPLEPPSQSRPEEQQQQQPSTQPPPQPQPQPPEQTPATSTTTPLPPTTTSQTLRSRQPPQPSTTTAPPTTTTAAAPNPTPQAATTTATSLFGSRAGTTKPSASSTTAVSTTEAILDHQRAEQDALSESILKLASELKASSHAFSASLDEDRALVERAGRGMERTGEQMSMVSRRMGALQRMAEEEGWLGRMKLYAMVYGLMVVLVLVVFVLPKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM45</accession>
    <name>A0ABR3VM45_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="116"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="381"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="625" mass="68490" checksum="110016E28482DC7A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMC8</accession>
    <name>A0ABR3VMC8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_3719</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="77"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="266"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="585"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1842931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="645" mass="72586" checksum="A9BE358CAFE546A6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMW1</accession>
    <name>A0ABR3VMW1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047286591" evidence="1">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="151" mass="16622" checksum="5F06BFE59D8F50D3" modified="2025-10-08" version="1">MLLTTFAKAIAATCMAALPVARASPASVGLDPGKEKDMVPILMCNEDKGRGWCDESLREVHKCYNLPDRVYHNLAWFIVQKDGYNCWVFREPCEDIWYCDLKWPCAVAGPVNASTGLGYAPGEWGWTDNAVSFDCIPKGDLGGVFGLKTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN86</accession>
    <name>A0ABR3VN86_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="406" mass="43444" checksum="CD4FB7CCDB611DEE" modified="2025-10-08" version="1">MASVNPPRGALASANDDDDDPIVASYSVFLKPPLPEHRKLVVFQFVTKTAQDPTQLRVPRITELRVKPSSGMYEVDVPIDTSEAYDRAKGLAWGTALHKSMESKKDGSLGLAGGFNIVATPGGAGGGGGRGRRAAAAAEDDDTPQTWAEAARQDKVLRTQTFGGVRSAQEKHTRHMIGVFQGKNLHLTPVSSVVHLRPVPHHIDAATEQDRLSRGAAATGASGGAGGADKAGASAARAIHMTIKSAMDGDNDGVATETIVDRLRRVQTESWRRMEWVHDEAEMAWEAYNECLLLRPNQNNGTDGADKDAAGDNGGGYDGENKGKGKEKETATEESSAADLIEKVMHLKTDWGEQELLQAISEGRGTISGLDAAAASIRAVYNEEGVQERGVEEYGYGDRLRDVYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNE6</accession>
    <name>A0ABR3VNE6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycoside hydrolase family 94 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11748">
        <property type="entry name" value="GH94N_NdvB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH94_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052047">
        <property type="entry name" value="GH94_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037814">
        <property type="entry name" value="GH94N_CBAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94_b-supersand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37469:SF2">
        <property type="entry name" value="CELLOBIONIC ACID PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37469">
        <property type="entry name" value="CELLOBIONIC ACID PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="GH94_b-supersand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase 94 supersandwich" evidence="3">
        <location>
            <begin position="76"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase 94 catalytic" evidence="4">
        <location>
            <begin position="318"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="91355" checksum="4A524D1FB47632AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNP1</accession>
    <name>A0ABR3VNP1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_2735</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1843184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="433" mass="47860" checksum="46C21DB6C2B92098" modified="2025-10-08" version="1">MASPASLPVRAVRFALDVANGRHALSKLVAPLLFLADAVLCVLVIWKVPYTEIDWVAYMEQVAQVASGERDYTRIRGGTGPLVYPAAHVYIYSALYRITDSGKDVLLAQQLFGVLYMAALALVMACYRKAGAPPYVFPLLILSKRLHSIFMLRCFNDGFAALFLWLTIYCLQRRAWRAGALAYTLGLGVKMSLLLALPAVGVVLLLGAGYATSLQLAALMALVQVLLAVPFLVVNPWGYLGRAFELSRQFLFKWTVNWRFVGEEVFLSRGFLLTLLGLHAVVLVVFLTTRWLKPARKPLPRLVVPILLGKSPFTEQEQRAISRDVVTPHFIMTAILSSNVVGLLFARSLHYQFYAYLAWSTPFLLWRSGVHPVLQFALWAAQEWAWNVYPSTSVSSGVVVGVLAVTVSLVWLGTGVSSERIRAAAAKDAAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNR7</accession>
    <name>A0ABR3VNR7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="222"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1355"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="964"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1469" mass="164924" checksum="9AEA7891A2B64DC9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPC7</accession>
    <name>A0ABR3VPC7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="119"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="451" mass="48080" checksum="CF1C9C95D71AC257" modified="2025-10-08" version="1">MTDLSRVLAHFPVGQFARLMPVLEKHDISTCDLLTLEAADIGKRTRLPLLDIRRLTAAVLDALHTDLGVSEGTSEPAESRGLTPGPPLPARPGAGLGPVHTTNHHQPALKNTAASLTTQWRTISTLDPELDHALAGGIPVGSITEITGESGSGKTQFLLTLLLSVQLPPPHGLGRPALYLSTEAPLSTRRLAQMLASNPFFKSLPPRNRPSLDNVLSTVTPDLESQDHIINFQVPVEVERRRIGLIVLDSVAANYRAEFDRGGPNGSRHGSNMGARAAELLKLGMHLRDLAQRHNLAVVVSNQVSDRISGDNLALPGPSLVVPTPTSSLRRPPLPPGHPPRQTQESPLASRTRPPSLNPDGDPNPDGPHSAADPDPDPVPAALSSAPQPPPSSTNAQPPAPFFPTHLLLDHQQRWFTGWGDDPPPSSSSMKTPSLGLVWTTQLGARIVLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPC8</accession>
    <name>A0ABR3VPC8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-processing protein prp40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="156"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="225"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="372"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="103361" checksum="A360BED34BDBBACB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPM9</accession>
    <name>A0ABR3VPM9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="689" mass="75447" checksum="6980749DC0EB0EB7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPN2</accession>
    <name>A0ABR3VPN2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9212" checksum="717158C4426F5B90" modified="2025-10-08" version="1">MCGFSEKTVVEDKAVLTAVDDSTPNTITKGSWKDESPSTATPSLSRCTKASIGWDGAFFCECPFCVCGEAVMYPGEVCFTCLKTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPQ6</accession>
    <name>A0ABR3VPQ6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="322" mass="36629" checksum="C5B0C6BA175E815D" modified="2025-10-08" version="1">MGIPAALATVAACGSIVTSLKSSWELRRMIKRKQDAKECEEEAPYVFRRLRRAYYDGLMSAHEYEQWYEKFLVAKVEKDLHALRRIRAHVRILEQGAPVTPSQRSRALEQVKEKQEERRRRHSVSHPRDYDDRPSQRETRGDLAAPLSKAALEYTPRDRQRSQNVQVGARPDQFVPVDRNETYGSSRSSSKNTEKTTSSSSSSSTTRCSSCGNCSSKTDKDGKEKSEKNKSDDEKPASHSPSSKVPSTKPSSSSSSSRTTSRAPSRTASASERPERHRGRSRCRRNESSDSDDERSGNESSEYCYYDDRSRPRHRGRSLSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ56</accession>
    <name>A0ABR3VQ56_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="153" mass="16094" checksum="3BE23B919680CDE2" modified="2025-10-08" version="1">MPPLRLTMPSKGAGPDALDETLGRLSKKPGVKAALVLDRESGAILKTSGQINSIHVAKPSGASSSSAAPAGAPSFTSTNNSEANGNDSPNPEQQATEEVAAMMWNFVSNAGSLVQELDAEDEVKLLRLRTKKQEFVIVPDPKYLLIVVHDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQD8</accession>
    <name>A0ABR3VQD8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="149" mass="16697" checksum="9A01A5052F702C3C" modified="2025-10-08" version="1">MSAFLRSIARPATAARAFSTTAQRPVARITIVGNLADSPELRASSTGREYLRYSLASNSGPSSNRRTSWFTVRCFAPEGPQREFFQSLPKGALLMVEGEVTVSNFTDEDGKPRQTYNITQRSLDVIRRPFNPNRQGQGEEEQQPQEQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQL0</accession>
    <name>A0ABR3VQL0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="228"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="10">
        <location>
            <begin position="316"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="513" mass="57490" checksum="2A4BD14A0075513F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQU7</accession>
    <name>A0ABR3VQU7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="53769" checksum="3DFC1F497085B1AA" modified="2025-10-08" version="1">MLPRAADLSCSTSTNFTHEPADLISRFPDVAVPRHDRIAGTSLPLTTSLSTGSFPSSPPDDNGDHIDPLNLALDLAAAPFTTVRIPIATVTMLTTVTLPFPSPTDATATAAIATAIPTTPALSQAEAEAAASGPHRPPNPGECSLLGPFAILVQLALGALALLSLVWKRWRERPQRPVRIWFFDVSKQVFGSVLVHAANVFMSLLTSGKFSIEADADIVAASAVTRMVRRAVEGVVQMGFAATSMAAMTTIGIPILIVIVRGLTHLVSFTPLGKPLESIQSGNYGNPPNAWWWFKQSIIYFCGLMGMKLCVLFMFMAFDWLPHVGDWALGWTEGNEELQIVFVMMLFPLIMNAMQYYIIDSYIKKQEAARTADGRSGTTSAGTTNARPSVAYEELRPAVESDNETDDDEEEDDDDEAARKALNPRRNGSSNSHVRGTHVRLARRDSAGVPRRSSTVHRDAATEYDPAVDGDTPTVVGSSSSRLSSRRALPKEFASQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQV5</accession>
    <name>A0ABR3VQV5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Extracellular mutant protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029178">
        <property type="entry name" value="Ecm11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF3">
        <property type="entry name" value="EXTRACELLULAR MUTANT PROTEIN 11 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15463">
        <property type="entry name" value="ECM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Extracellular mutant protein 11 C-terminal" evidence="2">
        <location>
            <begin position="533"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="678" mass="74647" checksum="E0530C8E5ABFEAD8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR63</accession>
    <name>A0ABR3VR63_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4951</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="556"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1844099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="628" mass="71182" checksum="3F1810B628AD7139" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRI2</accession>
    <name>A0ABR3VRI2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046617590" description="Alpha-L-arabinofuranosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1843993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="332" mass="36168" checksum="3B69431A8975B2DB" modified="2025-10-08" version="1">MKSTLPSLGLALLASSATVTAQEICDLPSTYRWTSTGPLAEPRAGWVSLKDFTTAPYEGKHLVYATTHDHGSTWGSMAFSLVSNFTELRTANQMGMNQATVAPSLFYFPPKDIWVLAYQWLIIMTPGGPTAFSYKTSRDPTNPNGWGPTQTLFSGRISGSSTGPIDQALIGDDTTMYLFFAGDNGHIYRATMPIGNFPGNFGSASTIIMQDSTNNLFEAVQVYKLQGQQRYLMIVEAIGAQGRYFRSFTATSLGGNWTPQAASEGRPFAGKVNTGVTWTNDISHGELIRVNADHTMTIDPCNLQLLYQGRSPNSGGDYGRLPYRPGLLTLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0T6</accession>
    <name>A0ABR3V0T6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_6817</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000691">
        <property type="protein sequence ID" value="KAL1835392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1835392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="136" mass="15173" checksum="97DD57D0F5862926" modified="2025-10-08" version="1">MSSILPASLQEGYLPFFMLYTCIAGIGHTAWCYLNPPSSALRMFSGPQAPPPTTLAAHIYAVKNFYTCAMRLYAVYNLNNRPVYNLAMLSYAGVIWLYLTEYAVWKTAQGKDAAVALTTSGIGLAWMVLQRGWYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1K2</accession>
    <name>A0ABR3V1K2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000598">
        <property type="protein sequence ID" value="KAL1835584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="366" mass="40850" checksum="E29B077B7A1F7BFA" modified="2025-10-08" version="1">MSFHNVKLESSSTGSSFPADSAKPVPLAVVSLDNDEAFGYLKRVIVTPAVYPRLVEFLHFDIQSTGQKSHCIPPVRTSSKLVVNRTPDGRSLLRASAPGCWKPPAGCPARGDLLPGRPPKAQRAQPLEPILFPKLRIYFADFPYLHCSINQRLFTLETCCGTSGAHRTRQKCRALPAIKPYLQTNCFQGDRPLRRKENSARGPRRRLRVQLRYRAKPTSRCRNINRLPFRHTGHKCPFETELPYGLGSTNPCPTAVHMEPFPTSVLQVLIEVFATTTKICTRGRSTRAHALGFVTDLHGRLLLRASGFRLPWPPSCCQDVLTPFVVSDERPLRHLNPAFGSSRIASSAYQKWPTSVGTFECPRSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1V3</accession>
    <name>A0ABR3V1V3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000599">
        <property type="protein sequence ID" value="KAL1835577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="139" mass="15503" checksum="E1D6DDE14FE47519" modified="2025-10-08" version="1">MGQIQTETPYFMPIPNALVPFPPITHLNDPFYAISCQGVEGNCAASWGLRVINSRDVFVYGAGLYSFFDNYSTACSTFSAGQTCQQRILSVEGWAKNVNVLNLNTVGTREMITRDGRRVAWFKENENTFASNVAVFRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1V7</accession>
    <name>A0ABR3V1V7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000565">
        <property type="protein sequence ID" value="KAL1835689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047444148" description="GPI anchored serine-threonine rich protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="16339" checksum="54574C73AF810019" modified="2025-10-08" version="1">MKAFLFPLAVLASSAAAQTTSECGAAYIVDACLTSEKAKLNACGDQDYVCRCDNWINVLTCYNNCPNDPRKHADDGQRQIFCDYASRLVSTTTQAAAPTQTSTPAQTTENAEAADPTDTDSPATSTSDAPTSTNHAADLVLNAGGMLAAVAGVVAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V244</accession>
    <name>A0ABR3V244_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000539">
        <property type="protein sequence ID" value="KAL1835779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="81" mass="9156" checksum="86C2DA952820386A" modified="2025-10-08" version="1">MSSPKDEEKPHDETRDHAETADNDEEEISAMKRRVAEMEAEAAKLREMQASLDQARQDLSEDKEEVDNRSIFVGNSDHPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2P5</accession>
    <name>A0ABR3V2P5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000488">
        <property type="protein sequence ID" value="KAL1835986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="542" mass="59143" checksum="9B32DB1EAE8A44C5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2U8</accession>
    <name>A0ABR3V2U8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000591">
        <property type="protein sequence ID" value="KAL1835608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="59" mass="6666" checksum="FA6CEC2C129601B7" modified="2025-10-08" version="1">MQSECETDETAPGFGMLASSHRIEPNHGVEMFGSWHRVSVVPRELVATPFWAAFMLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2V7</accession>
    <name>A0ABR3V2V7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000463">
        <property type="protein sequence ID" value="KAL1836113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="457" mass="50823" checksum="D9CB3AF1253265DC" modified="2025-10-08" version="1">MMLRARYIAVALVGFFVLLRWYKTPRQFTASDFGPLEPLNSTLGFQHIFAINLPSRTDRRDVLTLAAALTGLNISFMDGVAGADVPDSVLPGNGKRPMGLTVGNKGSWRAHMNVLQRIVQENIITALILEDDADWDVRLKSQMRVFAAAARAFTQPLSSSSSGRTTSDWQPPSEATLAEVYRHSPPTSDPVTNIPISRLITMDLPDSHLSPYGDDWDVLWLGHCGTDFPEEHSATDRSDDPWTPPPLRVTIPDDPTVPSPKHLVPHPFALGDALKKETFTGSDDEDEEWVEGEDLRRRKRYAPHTRVVHAPRRAVCTQAYAVSQRGARRLLWRFGVGMGLTAGWDLVLRDWCDGVYSSSSASHSGSHHRRGEEEKVKRRESGDGEEVVGDGRPPVCVTVQPPLFSHHFGKGKASDISAAGGGFWNRKGELTPYIRLSVRLNLGRLVNGWEPREQWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V327</accession>
    <name>A0ABR3V327_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000484">
        <property type="protein sequence ID" value="KAL1836005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="154" mass="17091" checksum="4A42E791CE2255C4" modified="2025-10-08" version="1">MTPRPGQGSAKGSVNVTAMRCERRNKDRTARRSAEVAADLVFPLLHHLRHCATKRKIVLKSPRRGRATPSVLVLLCCSPFCLISFDRPWHSRFLRRALHRPSLPRALGLGTPSARSHSNSGRSLGNKRKKVEYLGLCQPAPLDHSVTQSATTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3G7</accession>
    <name>A0ABR3V3G7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-protein ligase E3A N-terminal zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000429">
        <property type="protein sequence ID" value="KAL1836323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056012">
        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="7">
        <location>
            <begin position="131"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7590" evidence="6">
        <location>
            <begin position="232"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-protein ligase E3A N-terminal zinc-binding" evidence="5">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="81355" checksum="FEB8BBFA09497669" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4K2</accession>
    <name>A0ABR3V4K2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000377">
        <property type="protein sequence ID" value="KAL1836699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="short sequence motif" description="HGGXW" evidence="3">
        <location>
            <begin position="79"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="440" mass="47973" checksum="457BFFFDA0676879" modified="2025-10-08" version="1">MASAEDWAAWASVPWTAVPATSSSTPLGWHKTGVPYLPPGQALLLQTLDIWIPNTDQASSAPDPTTLPSLPGTWIVYIHGGAWRDPAIDSTSFSPAATLLLSRGTTTSSPTIAGLVSLNYRLSPHPSHPAPSDPARQAAHPDHITDVLTGLAFLHRLLASTHSSANPIQWILAGHSCGATLAFQAVASPSRWGLPLPPPPPQPQPLHFPKPTALIGFEGLYDLAGFIASPPEHYAWLREGYREFVSGAFGDDETVWRAVCPAREGGWEIGSEAGEFVKGWVREWVGDDGGQSREGEGRMKKVVLVQSWEDSLVPWQQVEVMRKCWGSLEGVDCLHNARHDMTNPKSMRRDTAGALLSFWLCFRCRKRPDSTSDWLVWLSNILQILNSGAPRVSTSSLTSRSHILGRTMCAENVQYHGSAIRQGVLNMKHVTSAPPIRVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4R7</accession>
    <name>A0ABR3V4R7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 11">Catalase</fullName>
            <ecNumber evidence="3 10 11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4697</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 11"/>
    <dbReference type="EMBL" id="JAZGSY010000369">
        <property type="protein sequence ID" value="KAL1836757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="43"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1836757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="739" mass="82697" checksum="1B18991E67661121" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V529</accession>
    <name>A0ABR3V529_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000357">
        <property type="protein sequence ID" value="KAL1836869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1067"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1259"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1017"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1084"/>
        </location>
    </feature>
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        <location>
            <begin position="1128"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1215"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1269"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1283"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1329" mass="142193" checksum="28902FBE7743DA4F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5N4</accession>
    <name>A0ABR3V5N4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_4307</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000332">
        <property type="protein sequence ID" value="KAL1837079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046734886" description="Peptidase M14 domain-containing protein" evidence="15">
        <location>
            <begin position="18"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="119"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1837079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="419" mass="45935" checksum="DC332D6DB7BE5242" modified="2025-10-08" version="1">MKFQLLVSSGLLALASAAAVQSPRKSYSGYKVFRVDVGSDATRLNNVVDKLGLSTWKGRPRPNAQADIVVPPSQLAAFEAEVAGLKKVTMHEDLGLSIEDETSFSTYAAGSANATWFNSYHAYKDHIQFLKDLQASYPTRSQIVTSGNSNNGNPITGIHFWGDSGKGKPAIVFHGTVHAREWITGMVVEYLAYHLLTNSGTAEIKGFLNKYDFIFFPVVNPDGFIYTQTNDRLWRKNRQTNSGSSCVGRDINRNWPYQWSLSGGASTNACAEDFKGRAQSDAPETTALANFLRTTKVNQGVKLYIDWHAYSQLFMTPYGYSCTAVAPKNAELQSLARGAANAIRAVHGTSFKTGPICSTIYKATGNSVDYANDVVGADYTFTTELRDTGRYGFVLPANQIKPSGEEAWAGVRYLLQNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Q9</accession>
    <name>A0ABR3V5Q9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000366">
        <property type="protein sequence ID" value="KAL1836786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Mycothermus</taxon>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1837187.1"/>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="973" mass="102565" checksum="8A581C7C3CBE3A22" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Drula E."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="842" mass="91181" checksum="23BFFE4FB41999EA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6D6</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Drula E."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="413" mass="45523" checksum="5A05278D3080B988" modified="2025-10-08" version="1">MHLAYLTGCPTVGNMAYEHRGIALKGLQEAVGTFSRETSDAILAASLVLSWQATDWRSWTQLMQGTLSVIEAMDPWKHESEFGNFIAESSTFPTAPSSPTPDHRPREPRADDLEAFQRALQQLQKLESFLKKNREDTKPVGQLITFMKGSRKVTSSLSVAQQFDRLKPLRAWLFWLPVQYLQQNGASPHALVVIAHYYTAALLMERLFPEIGAAYFGSMTIGPVEQIARRLYAIRNSGVLEGDLQTPLALMEFPIETVNEFRSRMGWVQPVRTPSFPQFEQPGFYGIDNGSPLMLSANLSSEYLPYVGDVAFSYSTEDLSVIPEAGPNGSLSPLQVPSPYINPQYLSIPSPSYAAYSPASSSFGDFGDASPLVYSDTEDNSPYGVDYAATSPMLGGANTYAVGFVPPIQTVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Riley R."/>
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                <person name="Haridas S."/>
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                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000294">
        <property type="protein sequence ID" value="KAL1837439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AWS_dom"/>
    </dbReference>
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        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="504"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="562"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="744"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="873"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="959"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="744"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="884"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="962"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1063" mass="112550" checksum="1DF2A68EAAA7788B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6U5</accession>
    <name>A0ABR3V6U5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mis6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000319">
        <property type="protein sequence ID" value="KAL1837191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
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        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="76762" checksum="AA6D21BDB7EF3753" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V761</accession>
    <name>A0ABR3V761_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000279">
        <property type="protein sequence ID" value="KAL1837604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="706"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="930" mass="101064" checksum="1A09188538CE8716" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V771</accession>
    <name>A0ABR3V771_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000308">
        <property type="protein sequence ID" value="KAL1837311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="414" mass="44231" checksum="50DEA5927958A17A" modified="2025-10-08" version="1">MTAMGVQLQPFGPGLEPYGSWNFGGAQLRKTRAELEAALLEPAAISDLSDRLLEISKAGITGCRSLRTPKGATVGPLERPPAVPKPTEVCWRLLPATFHPSLVFVRLRSADKTKFTFSAPSTATPQSRSCLKRRRPDTDVDGPNTSAVACKKRRLRRELVTSRLSQPFSLPATHVLNREVAATGDTRFAKLAAIMSARRLQGAAGLAVKVQRQPHPSTFLRRAAALNSLRARVCAAAGERANMPISDLSAKAAALRQSHGSTAARFLVDLIQPLRTTASPAARPSNSSVPMPPPGNTAQGATAGSTAPTTTSLRIPSPKLRPMRSPELRAARPFIELEDIDDLSVDEDSMAFPTSELESRYEDDLDDEDDDGSGVYTDFSVIFGGGGAPGDADDDSGSSGSSGDMFEDYLDDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V797</accession>
    <name>A0ABR3V797_HUMIN</name>
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        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000278">
        <property type="protein sequence ID" value="KAL1837620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF378">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046224388" description="GH18 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="54"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="163" mass="18618" checksum="FBA1E210D0B6C89B" modified="2025-10-08" version="1">MTSIKVVWSFFFTLFISISIAADTAARHDLRCLMYYTRYARAPRPRIADNKSDQRLTRMHHSQHPEAPPLDQLERVNHVAVASMSSESLNKNDWTLFTTIDDVRSKFANGTKILVAIGGWGDHKGFETAAWNDRTRKRFSRNVAKMVEKTGADGVDLDWEYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7K8</accession>
    <name>A0ABR3V7K8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000269">
        <property type="protein sequence ID" value="KAL1837712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
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        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="49"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1610"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1743"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="674"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="932"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1218"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1610"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1638"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1651"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1750"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1774"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1809" mass="200526" checksum="C514D0D13370A886" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7M3</accession>
    <name>A0ABR3V7M3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000263">
        <property type="protein sequence ID" value="KAL1837793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="363" mass="41257" checksum="09C7DE27AA196421" modified="2025-10-08" version="1">MANEPSADHRFMAADERLLRTGDFSDATLKCGDRTWKLHKNILCSRSVWFEKALAGRFKEASTGVIEIEDVDPDMMDAVVTFIYTGLFDFARFRRPGSLTNLNVYYDVYTAADYFALTPVTKLVLSTLQTEFDEILTHCQLQFKAESNWMPQFLEVVCLLWNDVPIKGCNVDSELSSRPGSGISTTVDINDIERPGKEQKTSDTANEQPSLPPVKWDLTPIRAAFLTFVNSARFFLLRNPTFTHFLDTNACPAFALDMFRAMRLTGDFVVRQSAGEYNNATCVGCAVRLPNQKTMASEKPIFYWPLLELSRDKVRSYCAVCAEKWGKKSEVGWITNQNAPDPPYIKKTLDDGFDETYPLPYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V840</accession>
    <name>A0ABR3V840_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000249">
        <property type="protein sequence ID" value="KAL1837960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="78" mass="8081" checksum="083E65F073B3B06D" modified="2025-10-08" version="1">MTSTGTAHVRPQEGEDGGAVKDNMRECESGVMLEHTAQRGSHGLCGGSGGGGGGGGENGTLKRSVEKQQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V850</accession>
    <name>A0ABR3V850_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000249">
        <property type="protein sequence ID" value="KAL1837958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4187" evidence="7">
        <location>
            <begin position="1261"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="910"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1197"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="983"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1087"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1136"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1155"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1197"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1314" mass="142794" checksum="3F84A60E9919B72B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V887</accession>
    <name>A0ABR3V887_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="15">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_3123</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Endoplasmic reticulum membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Microsome membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000243">
        <property type="protein sequence ID" value="KAL1838029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="17">
        <location>
            <begin position="223"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1838029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="772" mass="84426" checksum="3B3A02AE71DD8B6C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V896</accession>
    <name>A0ABR3V896_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3143</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000244">
        <property type="protein sequence ID" value="KAL1838020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="641"/>
            <end position="911"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="129"/>
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        </location>
    </feature>
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            <dbReference type="PROSITE" id="PS50105"/>
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        <source>
            <dbReference type="PROSITE" id="PS50200"/>
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    </evidence>
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            <dbReference type="EMBL" id="KAL1838020.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="915" mass="101159" checksum="FFACF5A6A21750CB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8I1</accession>
    <name>A0ABR3V8I1_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">Cellobiose dehydrogenase-like cytochrome domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
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            <end position="18"/>
        </location>
    </feature>
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            <end position="216"/>
        </location>
    </feature>
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        <location>
            <begin position="26"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V968_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_2700</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Soft-rot fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000217">
        <property type="protein sequence ID" value="KAL1838388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1838388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1037" mass="113280" checksum="2476B89C74270A5C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V997</accession>
    <name>A0ABR3V997_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARS binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000231">
        <property type="protein sequence ID" value="KAL1838195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018562">
        <property type="entry name" value="ARS-binding_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048:SF1">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09441">
        <property type="entry name" value="Abp2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
    </feature>
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        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="91946" checksum="97F314FFE03E3821" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9L3</accession>
    <name>A0ABR3V9L3_HUMIN</name>
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        <recommendedName>
            <fullName evidence="6">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">VTJ49DRAFT_2650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000213">
        <property type="protein sequence ID" value="KAL1838453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="EmrE-like"/>
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        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
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    </dbReference>
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    </dbReference>
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            <end position="87"/>
        </location>
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            <begin position="399"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="627" mass="68066" checksum="E91B873B5DCBFBA5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9N3</accession>
    <name>A0ABR3V9N3_HUMIN</name>
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        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_2543</name>
    </gene>
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Sordariomycetes</taxon>
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            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1838545.1"/>
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    </dbReference>
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            <end position="16"/>
        </location>
    </feature>
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            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
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            <begin position="121"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24435" checksum="D03C392548F97542" modified="2025-10-08" version="1">MKSILVTSLLAGLAMAANPIFKSTPYDECNTCLDNAVAECTGGLDSPDFGTCMCNAEQPAGDGYRAFANCLLECINLRQKQSGPISVTRGIETDMHSYCARWFPDKYCRTKLWDTLTDEADEKYCGGSDTEDDDDPTLTDNDDPTLTDDDDPTLTDNDDPTLTDNDDPTLTDNDDPTLTDDDDPELTDDESGSTGSSRASNQPNAAMALAGAPAWLMAVGLGMAVVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9N9</accession>
    <name>A0ABR3V9N9_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein ALB1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_2621</name>
    </gene>
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        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000211">
        <property type="protein sequence ID" value="KAL1838483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16638" checksum="3E979F7226A47408" modified="2025-10-08" version="1">MPSIKNPNFLSKNRLAARAAKLKKQRQKAAERNRLAKVPGGEELAKDVKRGARPGLLPTSGPRAAISKKKLRKLERMRGYVLKRKLEQEGLIGEEMAVDGKLFFLSSGSDASLRWWANVRVTDAPQDGKGKKQDKGQEQQGGDDAEMDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9P7</accession>
    <name>A0ABR3V9P7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000211">
        <property type="protein sequence ID" value="KAL1838490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="578"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="745"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="961"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112039" checksum="A18C33DA2769369B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA04</accession>
    <name>A0ABR3VA04_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000218">
        <property type="protein sequence ID" value="KAL1838382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="100"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="380" mass="41871" checksum="D0533F5618F49886" modified="2025-10-08" version="1">MVFSRIDGTDELYLGGIFGLRRTQVIRELKITHILSVIKTTLKQDELGHIQHLSIDINDMEDEDILVYLPRMVRFIDRGLRGSEGDEGEGSNDVTGASADTKASSGAVFVHCAMGKSRSVTAIIAYLLWKCPRRFQAPTSREAVAKALEWIRRSRPIAGPNEGFMSQLELWYDMGCPTDNDNAVEKHPAYQRWLYKREVEDAARIGRAPDRIRFEDEEASSEGQTADGQGAGPGCELRCKKCRRVLATGRFIVPHQASENGKQQQQHQQPCPHFFVEALSWMRPVLEKGELDGRLTCPNTKCAASIGRYAWQGFKCSCGQWVAPAFSLQTSKVDEVIVGGKGGGGAGTIAARMAALNIRMPPGMGASVASEGAERTRENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAD5</accession>
    <name>A0ABR3VAD5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000192">
        <property type="protein sequence ID" value="KAL1838800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="61"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="426" mass="46237" checksum="F7CD350C390326C6" modified="2025-10-08" version="1">MGSLPEPQPFRVLIAGGSYGGLSVAVNLQDLCRGLPARSGPKPEEDSGTPQSAPAPEIPVDITIVDERDGYYHTIGTPLALASESFAEKCWIKYADIPALRAPNLRVLHGSLKSVDPERKVAAYVPNGSTAAPLELHYDYFIAATGLRRAWPVVPQSLRRKQYLFEMGDHTRAVSSARHGVLVVGGGAVGIEMAAELKMVHPHLNVILAHSRDTLLSSEPLPDELKERALELLREAGVDVLMSHRVDRAEDVKDDTGNPCLRVHFTNGHSMLVDHVSMAISRPVPSTTFLPQSVLDEEGYVKITPELRFPADAPNSTVHFAVGDLARWSGIKRCGGAMHMGYYAAHNIHQHMKVVAAASRGSEEEPEDKQLNEFPPVIGLAIGKKAVGYWKEAGVTSGEKELKDFFGDDLGFSICWNHLGLGGDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAG5</accession>
    <name>A0ABR3VAG5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000194">
        <property type="protein sequence ID" value="KAL1838775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045169138" description="Peptidase C51 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="122"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="250" mass="27417" checksum="3D570C838425F540" modified="2025-10-08" version="1">MKFLAIAAFIGTVAVPLASAYPVEDEFVDCYSGPDTTYDVEEVYPAGDEINVTCQIAGESVDSAETWFKTQDGCYVQDVYVHTGNETITPAICSSDDDSSDSNNSTITARAIVGRADVGSPIKDDYPSAYKSQCGGVDPWRYYKCQCVSFAAFRINKRLNIKFTNSYKGQAWGNAKTWYNAAKKAGVKANNTPKPGAIAWTDKGSAGHVAWVAKVSGDKVTVEEYNWNNPKRYGKRTVAKSSFKKYIHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAM9</accession>
    <name>A0ABR3VAM9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="631" mass="68914" checksum="58C4B4AD23A18DED" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAU4</accession>
    <name>A0ABR3VAU4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000183">
        <property type="protein sequence ID" value="KAL1838958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="5">
        <location>
            <begin position="293"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="644" mass="73016" checksum="0836A59F6767172C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB31</accession>
    <name>A0ABR3VB31_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1913</name>
        <name evidence="9" type="ORF">VTJ49DRAFT_6130</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000178">
        <property type="protein sequence ID" value="KAL1839049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="475" mass="52228" checksum="69BDA7CA1CE91D24" modified="2025-10-08" version="1">MADIRDLRIAVIGAGMGGLGVALACAKKGFRHIDVFETASDLGFVGAGIQMPPNLVRVLSRLGCWDDIYAEATNVKGTSIREGSTNEELSHVAMPDIEEKYGFPHCTGHRASLAGGLYKACKQEAAIQFHFATVLVRYESFGPRPRFVVRPRDGSEADERVVEVDLVLASDGIKSATRHQILAELGVEAQEEDTGQAAYRIMLTRSEMEHDPEMLALLDSDEVVRWIGERRHIIAYPVSSKQIYNLSSTQPDVNFAKATNATYTTRGSKSAMLKVFEDFCPLVHRMLNLVPDGEVCEWKLRSHKPLPTWVHGSVVLLGDACHPTLPHLSQGAAMAIEDGAVLAEVVSRVAVDANTTVEDRAAAISRAFKVYERLRKPHCTALVDLAFKSGRVLHLGEGKAREERDREFRLNGKTGSVPDKWASPDVQKMIYGHDCVKEAADEYDRILAEIKKEEKVQGKTNGPTEPPSLAYSPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBH3</accession>
    <name>A0ABR3VBH3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000172">
        <property type="protein sequence ID" value="KAL1839165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="333" mass="37032" checksum="653A07FC483C210F" modified="2025-10-08" version="1">MSNLFSGINARFRGQKGTNSPGPSSPSPEQQQAKAQAQAQSPAVPSPSIQGGQSPSSNLPTTGMMQSPEDVLASYHLPPVKPLWLNANYAKHIVKGNFLTLSAKPKTVELGEWIAHQVVDHWRMLITYIRLVHDKEEDGTSICNSKRCPKMSAGSNHSFTWLNSRYQPVEIPAYEYLTLVQRYINGKIDDTTIFPTDPAGVSYADNPAFCTPLPESGQDWIGKRSGFPQNFMETCQTIFRQMFRVYAHLYWSHFEDMFCLNLEKSMNSCFSHFILTATTLNLLKKSDLEPMQPLIDLWAALGTFPQGSKAYEIANLAVGNFLIQKAGGPPPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBK0</accession>
    <name>A0ABR3VBK0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000175">
        <property type="protein sequence ID" value="KAL1839098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20805" checksum="3FB50D3EA77D02FC" modified="2025-10-08" version="1">MITDMSGPIRDLTMIVTQTRDLAMSAVAIRDIEPGQEITISYIPLGMPTIHRKQALGNWGFNCTCDLCTAPPETREISDERRERLVEIYYAMQDETTNYDTLVELSRELVQLARDERLLARAPEYYQSLMRIFYSFGDQETAWKYGRMSLKLAEILSDPEGEFVSGIRRDLDGIDGFFREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBU7</accession>
    <name>A0ABR3VBU7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000164">
        <property type="protein sequence ID" value="KAL1839325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09615">
        <property type="entry name" value="Jacalin_EEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="328"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="459" mass="49734" checksum="B9153FA3CC1A2F86" modified="2025-10-08" version="1">MKPSTLRRKSRALKAAAAAALVFPTACHAATSGNFSILSMNVAGLPAFLNGNDVPGDKATNHKLIGQKFNEYGYDVIHVQEDFNYHAHLYSTNTHPHRTPTSGGVPLGSGLNTLSRHPYLDFRRIKWNTCSNQDSADCLTPKGFTFMRVALATDSSSSSTVYADFYNLHADAGVSSADLVARQDNVRQLAEYITRWSAGNAVVVYGDFNSRYSRGGDTGIRTLLAAGMRDPWVELRRDGRVPAPGEEDACGNPVAGDARCETVDKVFYRSGPLVGLKAREFAYDGLRFLQADGKSVLSDHNPVRVELSWEGSRKLRQSALFGGEGEGAAWFSDAVGLERVDKPRVAVVRFRGASRLDGVGLTLRSGEVFKHGGSGGNEVALTLGEAEYWTEAELCKGEKSGKVRNFYIRAATSAGRTLAAGTRTRDCATFRAPSGWHIVGFVGQDGDEMDQLAFVYAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC49</accession>
    <name>A0ABR3VC49_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-1,3(4)-beta-glucanase 1 carbohydrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000157">
        <property type="protein sequence ID" value="KAL1839430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018909">
        <property type="entry name" value="Eng1_septum"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10645">
        <property type="entry name" value="Carb_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-1,3(4)-beta-glucanase 1 carbohydrate binding" evidence="10">
        <location>
            <begin position="446"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="670" mass="74051" checksum="2C664486C2846F39" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC84</accession>
    <name>A0ABR3VC84_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000174">
        <property type="protein sequence ID" value="KAL1839117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045125251" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="103" mass="11488" checksum="F53F566DD85F683A" modified="2025-10-08" version="1">MKLSALAILGLAAYAQGAKIIACYKADFGGECKEETEGKLVTHTYKFKSYKWTGSKNKCVRICDSCKSLGYRCDDYNNNSIEFNKAIIFDWDKGDGPDNTMCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCS1</accession>
    <name>A0ABR3VCS1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000171">
        <property type="protein sequence ID" value="KAL1839186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="155" mass="17479" checksum="D987B9D743F04D94" modified="2025-10-08" version="1">MNSTASPYRPYHYIHTQPHSSLSDPTPPPTKPIKVFAALLQFSSLFLSFLSLGDRRQNSRNRPQSTPRREDVNAGLSWICFLFVQNGGSTQSSWHAEGYSFSRWIFLRSRPPTAILTRRTTTSSLFSSRGTRFLHPGRWGGLDISAIFGLAMLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCS6</accession>
    <name>A0ABR3VCS6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="273" mass="31765" checksum="76991033715C3A44" modified="2025-10-08" version="1">MKAMLFGPWKERKPDIGEWRVDLPDDDPGGLEILLQVVHGNPANFDLTRIRLFHLPAIIAIVDKYCMEELFRPWIQLFLRQHSERGWHEKHSTNFDLDFLRDLEAAWELGLASVVETFLAALMWDGWADDINTLASYGGFFQDHPHFLEFPTDPLRQLMERRLCYNAKIAAINGYLNGEMVELPSSAHRVDRSIDAWDNRVDEAFLAVQPRQGHAGCSLNGRCDAFREWLIQSKGWYQFLTAKDRAEIDERQKDWGCTMGDTLYWIGRFTYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCV1</accession>
    <name>A0ABR3VCV1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000169">
        <property type="protein sequence ID" value="KAL1839216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF5">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046972369" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="334" mass="36899" checksum="47B80FA92FCE1775" modified="2025-10-08" version="1">MKWLSLSLLAGSADAALRFGCSTVSIQRLDPLVEPGKIPSAHVHQIVGGNAFNATMGTNIADEATCTTCTFSENFSNYWTAVMFFRHPNGSYKRVPIMQNTALPNGINGGMTIYYTQQDFFSNGNQKITAFKPGFRMTVGSPTYSAQPGSRGNPGLRFVCLENKGTRFPELPTFPDRPCRGGIMTVHHFPSCWDGKNLDSPDHQSHMYNTVREAFTPAGPCPSSHPVRMPQLAFETLWDTTQFNNMWPADGKNPFVLSYGDELGYGTHADYVFGWQGDALQRAMDSSCMFQACENGRPLKSQSVQAMNACQVKSQVREDLDGWLNYLPGQGPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD35</accession>
    <name>A0ABR3VD35_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit CDC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000173">
        <property type="protein sequence ID" value="KAL1839133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44012" checksum="1E167FA2BA42E6B8" modified="2025-10-08" version="1">MLRRLPTVISLSPEDIADYEDRAAERARAAELEARQHAADARARARLGGSPSAGAAALRRAALAAETPTTGYGNSHSPIDYHDHHMPSSPPEHHFTDDDHDQGLDDDEEESEVETSYYARAQSQAARVVSFGRGQISPPAPPHLYHRHAAGVEDDEDVDVEQEEEEEEEPEEAEEIQEAHHRPPAARTRHARQASHPPHPTETPPNPRDARHHNAHHPLNHQPPPIQRRSTRERTADRDQATPPVRETRHRRAAASLTTDSDPSAADQDPNPDLDLPQPPPAPARNTRLRGRGHSTRSAATPTAETSPPPPPPPVRETRQREPRRAAAATATPVADAPPPPPPVRETRFRYQAAPPPSSSATLPPASSMPSSAAAVTPEARTQRSRDERIGVAAPRRGRGAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDT5</accession>
    <name>A0ABR3VDT5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000133">
        <property type="protein sequence ID" value="KAL1839967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="129" mass="14392" checksum="23C873E8B4E3C662" modified="2025-10-08" version="1">MSSQPLLQTAPGKRIALPTRVEPKVFFANERTFLSWLNFTVILGALAIGMLNFGDRPAFISSFLFTGVAMATMVYALVTYHWRAKSIRMRGQAGFDDRFGPTFLAAILFLAVVVNFVLRITYAPEDVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE02</accession>
    <name>A0ABR3VE02_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000128">
        <property type="protein sequence ID" value="KAL1840074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="197" mass="20888" checksum="E2B0228B231FA3BD" modified="2025-10-08" version="1">MATIGTLERVTAASLSKILLAAQEAPAAAPNIAIIDVRDDDYIGGHIKGSRNVPSRTLDYMLPTLVRQLQDKDTVVFHCALSQQRGPSAALRYIRERERLLGAAAAAANKSANPTTAAPSSSLDATGSSAGETSNAAADGTAVTAAAATESGIQPVVKEQKVLVLDRGFVGWQEEFGTDERLTEGYRKELWEDGYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE96</accession>
    <name>A0ABR3VE96_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000124">
        <property type="protein sequence ID" value="KAL1840164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="57857" checksum="C622552473749951" modified="2025-10-08" version="1">MLIHDLPTELLDAIVAVICRDRDTDPSVPSCVRWFSYFCDCPWPPTDGQDLSPCQRNRQREITLKSLCLTSRALHTVALPHLYHHLWPRDWQVLARTLAARPDLARHARSLIFGAWQDLAQRHPEPWKYISRLNLAAETPLVSCFEFRRYEYLARCRPWNLYIRPWDVERRRVTFASCVAGNDTLALDLLVSMLPNLHTLIAGLNLFYAFRFCRPGSLPRLRYIHLYPDDQCRMLMSWHMPGLMRVFAAAQDSLESVVLEVCDKFQLEPQSPEPSEDGSDEEEVEEVANDGGELEEQGDDDEDSEEEDEGNEQADEADQVVEQPTAEQQAAEQQAPDQQQTEDQPAEQQQAAEEQEEEEEEGFRIICPRVTHLTILDRSFDLEFLRHIFVSFPNVTHFYFQLYGPGTMRPGFGEDLEDDNHEPLDQTVSFFRSRSPMRAPKLQSFVLEIKDTYTNWRRWLVEDHVAALLAEMEERGVKFELRPPSTSRAGAAVAGNGGHQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEQ1</accession>
    <name>A0ABR3VEQ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_795</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000127">
        <property type="protein sequence ID" value="KAL1840100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1840100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="189" mass="21490" checksum="03C3B83E177346DE" modified="2025-10-08" version="1">MWIINWFYDILSSLGLVNKHAKLLFLGLDNAGKTTLLHMLKNDRVAILQPTLHPTSEELSIGNVRFTTFDLGGHQQARRLWKDYFPEVNGVVFLVDAKDHERFPEAKAELDALLAMEELAKVPFVILGNKIDHPDAVSEDELRHQLGMYQTTGKGKVPLEGIRPIEVFMCSVVMRQGYGEGIRWLSQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF42</accession>
    <name>A0ABR3VF42_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="230" mass="25637" checksum="7715FEBCB0C0574D" modified="2025-10-08" version="1">METLLMRPVASCCRRLASSATRTPTPAMLLPQQPARGKATSARARRALNIPPHPSFLNSNKTADASNQPTEEIIYNPPESAASVYHTPVKFLPPSDPRRRANLAEILAASNPASSSSSSSPSTTQPSVESFPMLSKSAPAPKPRHHLTKEDIEEMRRLRAEDPVTNSVVSLARRFDCSQLFVLMCCQAPKEHREKMKAVEEKYKARWGPRRRAAREERARRNVLLYNGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFE2</accession>
    <name>A0ABR3VFE2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000131">
        <property type="protein sequence ID" value="KAL1840003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="163"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="400" mass="43883" checksum="131FCF124BAD669F" modified="2025-10-08" version="1">MPSSTSTRRAQAAEQQFVAVTRASRDSAQAASHAETSDETDRDGSSDPVNSAGAATAGTGSCLAPSTPSAAPLPTQPPHPAKLPIRNNNNNQNHFFFNRNNNNQPPNPPPPPPPPSSSSRDPTMPRVSKKKQSKSKANLKVQAARYFADKQGDDGPSQANLNSLKTQLGKLFDELVPESEKGADAIGAEGCQAYIQRLGADPETYEMFVVLETVQAESIGNITRSGFVEGWAKVASETGGAVGADWNSQKRHIRSRIAAVSSDPNYFKTLYDFAFRIGREPGQKALDMAYALAFWSVLFAPTMNSWRSANVDWLASWSEFLKEKYGVVRSDGDDDEEVVEYKRTVSRDLWSQTRLFAAKTLQDETLGFWSEDQAWPGMIDEFVVWAKEKGIVPQADRMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFY9</accession>
    <name>A0ABR3VFY9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000114">
        <property type="protein sequence ID" value="KAL1840422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047404543" evidence="3">
        <location>
            <begin position="26"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="407" mass="42926" checksum="EC5DAA50516E8789" modified="2025-10-08" version="1">MRRGTTLRRIAASVASASLFSSTLALPQVGITADPAPITWVTVDASGSAHTVTPGVFTTEGHRATVSQAPDALRSTATYTLSPPGGSYTTYTGLAPVASATGANGSPEGIFPACDAEANVGRTEPFCLPRAGSELVQGKTYYSTSLLPFTPFTVLTITNTPKVTWSGSYFQPPTLELTLHVHYSSLTPSEDPLGHIGHVSEPFPASQGFYAWTIPDDFLSQQDRGNPNRMNVTFVLAYADASTPAESDQSTRVGPSVFVVAKDRKHVISNNPDDDDDDDDDSGSGGGGGGTNILAIVLPLSIIAVLLVLFGFCYTRYRRTGTIPLVGGAVTNLRRRSTGGGYGVRQSRAERTGNVAAGAGAVTPDHKSETGVDGGIQLTDRESWSPRSGRNVFREEVERQAKDQGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG42</accession>
    <name>A0ABR3VG42_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046342693" description="Glucanase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="470" mass="52449" checksum="10A104D243BA5ACB" modified="2025-10-08" version="1">MMRPSILALTLSLPLATSQRVGSLLPETYPRLTWSQCTTNATCEPIPGLLVLDANYRFLHEVDTDRPCFQSNSWNLDVCNTSATCSERCALEGARYRESYGVATPDEISVAQRLRANNPAGELIPGVPDYERTAGSRLFLLESRSRYRTFTLLGNELAFDVDLSTVGCGINAAMFFVPMDADGGVARDRGRNEAGAAYGTGYCDATCGRDLRFVPGLGANVEGWTSSETDPNGGEGRWGSCCPQMGVWNSNAHAFSLSTHLCSSQGREPGPWLCEGRYCDPFYIDPEDRYRLSCDYLGCSYNPYRVGNREFYGKGKVVDTTRKFTVVTRFSETNVTQFFIQNGRRIDMPGPSNSQYLPAEAGLYDDMCFMEAVVFDEFDRFAMAGGWPDHIRQILTQPMVLTFEIGTDYWAWNTWLDSIFPNDGLEMPGRERGPCPPEENDPRVVEKKHQDAQVIWSNIRFGPIGSTVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGF4</accession>
    <name>A0ABR3VGF4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_726</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000123">
        <property type="protein sequence ID" value="KAL1840196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="157"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="246" mass="27678" checksum="1D4CE9DE65D96775" modified="2025-10-08" version="1">MGESRQELVNWLNSLLQLNITKVEQCGTGAALCQVYDSIFLDVPMSRVKFNVNTEYAYIQNFKILQNTFNKHKIDRQIPVEQLVKCKMQDNLEFLQWTKRFWDQYYPGGEYDAVGRRKGSALPPSGPTGAAPRAPSGASRRTGGSTPTTGPRLGVGKGPGVGPGTAALQQEINTLKETVVGLERERDFYFSKLRDIELLIQQAVEEDPELEKQEDGLIKQIQTILYSTEEGFEIPDQEQVDDQETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGM1</accession>
    <name>A0ABR3VGM1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000113">
        <property type="protein sequence ID" value="KAL1840438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="891"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="248"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1329" mass="146074" checksum="51A0F7BD51AEEE4B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGM6</accession>
    <name>A0ABR3VGM6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000091">
        <property type="protein sequence ID" value="KAL1841004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="345" mass="37668" checksum="C9FA96CD21033DCF" modified="2025-10-08" version="1">MFDLVPNLLSSVASFLFPVFASYKALKTSDPAQLTPWLMYWVILAFVVLFESWTSWILFWVPFYAYIRLLFLLYLVLPQTQGARFLYETYVHPRLEENETAIEEFIASAHTRLRSAGISYLKRAIELLRTNVLGLPPSPEAREQAAPEPQSPQSYTQALLARFALPTPPWATTAGAAPQGTTTTYATDLYRHIASAIAAATTTPSTTTKPPAATPTPATATTTTSLIPDSVLAAGTAARALFIRNLREQLSTTMSALDREEAAAAAGEDASASLRSDNNNKDDNGKRRSLSEQSVASGLSKSRSEGDFEKLDAPSGEEEEEGQGLRRRGIGRKETGEKSGGGWIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGQ0</accession>
    <name>A0ABR3VGQ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="9"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="402" mass="45418" checksum="5B378147DA260FA8" modified="2025-10-08" version="1">MGGGPTTGYRSVAYFVNWAIYGRKHRPQDLPVERLTHVLYAFANVRPDSGEVYMTDPWSDTDIHWEGDSWNDTGTNLYGCLKQLNLLKRRNRNLKVLLSIGGWTYSPNFRQPASTQHGRETFARTSVELLSQLGFDGLDIDWEYPQNPSEAADFVSLLSTVRSELDAYARRVNPDRPPHFELTVACPAGAHNYNNLDIRNMDHYLDFWNLMAYDYAGSWDRVAGHQANLYPCTHNAAATPFSTDAAVRHYMSQGVHPSKIVVGMPLYGRAFEGTDGPGTPYNGIGEGTWENGVHDYKRLPLEGSDVRMDYDAGASYCYHPGRRVMVSYDTVDMARRKAEYIRQCGLGGGMWWESSADKEGPESLIGNVVDVLGGRHALEWRENCLEYPFTKYDNLRNGFPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGQ4</accession>
    <name>A0ABR3VGQ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="203"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="407" mass="45615" checksum="FAC11B16E2D423E8" modified="2025-10-08" version="1">MAPSAISETYPSSGAADSTTPSFTGYDHVHWWVGNAKQTAGYYTTFFGFHTVAYRGLETGSRYFASYVLANGDVRFVFTSPLRSAAHLPADEPISPEDRALLREMHAHLERHGDAVKDVAFEVDDVDAVYDRAVSAGAVSVRPPQTQGDKETGFVRTAAIRTYGDTTHTLISRSTFRGAFLPGFRAVPSTSSKIPFPRVPLARIDHCVGNQDWNDMLTACAFYERCLAFHRFWSVDDSQICTDFSALRSIVMASPGNELVKMPINEPAPGKKRSQIEEYVLFNSGPGVQHIALLTPDIVTAVRALRARGVQFIDVPRTYYDTMRKRLEVEPRGWELKEEMDVLEELSILIDYDEKGYLLQLFTKPLMDRPTVFIEIIQRNDFDGFGAGNFKSLFEAIEREQAERGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGV1</accession>
    <name>A0ABR3VGV1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="41"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="400" mass="44318" checksum="95B0E6C9D370B8E1" modified="2025-10-08" version="1">MGADEKTRTSGEQPREQSPVLPTVNPEAERAQPPKQSLHPAIYVSVWIALSSSVILYNKWILSERAFEFPVFLTTYHLAFATLMTQLLARYTTLLDGRKTVKMTGRVYLRAIVPIGFFFSLSLICGNRAYLYLSVAFIQMLKATTPVAVLFSSWMLGVSQPNLRVFLNVSVIVIGVIIASIGEIKFMWIGFIYQIAGIIFEALRLTMVQRLLSSAEFKMDPLVSLYYFAPVCAVMNLVVAVFWELPKLTMDDIDRVGLIHFFLNGLCAFMLNVSVVFLIGKTSSLVLTLCGVLKDVLLVIASMILFASPVTGLQFFGYSIALGGMIYYKLGYEAIKGYAAEAGRQWAEFGNRQPVLRRIAIIALALMTAFVVLGGLAPASYDNATQVLNEAKSKMGITKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH12</accession>
    <name>A0ABR3VH12_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000085">
        <property type="protein sequence ID" value="KAL1841139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="411" mass="46417" checksum="4F0996D69FF9A89F" modified="2025-10-08" version="1">MAGVSDKARFYLERAAPELREFEEKEIFTKDEIRALVSKRSDYEHLILAPGTKPTDFLAYVEWERSLDRLRAKRCRRLNIRSSSSHASQARTFGIFERAVLKHPGCVPLWLAYLDFAADVKATKRWRRICTRALRLHPTEAGLWALAGRRAARSGDMERARAHFLRGCRFCTREPTLWVEYARCEMEWLARVEAKKKGKGVRKGVNVMEAIKATEAVQEGDTIQLDDDDDESGDEDELLLPDPDAQVQGSKSKPKVFNEEETKKLDQSPALSGAIPMAIFDISRKQPFFGPAAAEMFFDAFARFGDVSCQEKVVQHVLAAMEELFPNHPCTCSCQIRQPLIGVGVLTAAFPKALRESLTRLKGALERTNDRTTLASKMVAWLDTVLETEGLDEAIKTVLEHTKRSLKESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH48</accession>
    <name>A0ABR3VH48_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="468" mass="51167" checksum="D35C00C4D403AB48" modified="2025-10-08" version="1">MSDTPAPRQYVPLTCHGHSRPVPHLSFSPLEKEEVYYMISACKDGNPMLRDGQTGDWIGTFLGHKGAVWQARLSPDATTAATASADFTAKIWDTHTGELLYVLQHDHIVRAIAYPFDQSGMIATGGFEKKLRIFDFHDQRPVAESNGPVTPVTIETSRAFEIGEGVHKEAIKFIVWAQDPRVLVTASGDTLRWFDLPSRRCIRELRLEAEIKSCELVTLAPSYSSPSDIGGGLPVLAVAAGKTAYFWGGPRVEDELKQFKLPHGIASVGLDVKGRKFVVGEEPGTWARVYSWDDGKELDVHKGHHGPIWSIAFSPDGKLYATGSEDGTIKMWKNCDGDYGLWRGGVIATDLPDSKAPIPADKQGPKDATYPPSSEATTAHPATEKVESFSGSAAKTIGNPTSKAPLERGSESSCSSQLSSAEKGGSSQFRCTCSSCPWHNSPEKTEDSRLQEFLRRSAMHMIHARPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHN8</accession>
    <name>A0ABR3VHN8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="355"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="446" mass="50494" checksum="9A1D5E621C2CCE47" modified="2025-10-08" version="1">MKIKALSRSISATQAPGSDVQRAPRNLAPEIHPFERAREYQRALNAVKLERMFAKPFLGQLGNGHVQGIYSMCKDKNSLNSVASGSGDGIIKVWDLTTRDEETWRTAAHSNIVKGLTFTNDKKLLSCATDGIKLWDPYNTPSDTTPIATWQEGGPYTSLSVHRTGSVFAASSGAGCIRVWDLAQSTAAQTIQWPSFTDTITDVCFNQVETSVIASVATDRSVILFDLRTNLPVIKTVLQFASNRVVFNPMEAMNLAVASEDHNIYIFDARNFSKAQNILKGHVAAAMDVEFSPTGEELVSGSYDRTIRIWRRDQGHSRDIYHTKRMQRVFRAMWTMDSKYLLSGSDDGNVRLWRANASERSGVKTAKQRQALEYNNALLDRYGHMPEIRRIRRHRHLPKVVKKATEIKREELAAIKRREENERKHSVKKFEKRKSEREKVILAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHP8</accession>
    <name>A0ABR3VHP8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="5">
        <location>
            <begin position="257"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="596" mass="63472" checksum="A825770179DAC6C5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHQ2</accession>
    <name>A0ABR3VHQ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="697" mass="78382" checksum="EBA93E51C64B9866" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIH4</accession>
    <name>A0ABR3VIH4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="138" mass="15563" checksum="0C363FC55825C0EF" modified="2025-10-08" version="1">MPPTIPQRGGPGGLKRSGIAGKTIKTAAKRHRKIVKDCIRGITKPAIRRLARRGGVKRISGMIYDEARDALKTFLTTVIRDVVTYTEYRNAKTVTVNDVIFALRRIGKPIYGFDPETYDPRKRKLNIDAPRARNDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIK4</accession>
    <name>A0ABR3VIK4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2283 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7315" checksum="BEF17E819AA510BC" modified="2025-10-08" version="1">MSEYRPATSAISGEALALDYDDGRVVAIVFSNDHVPEGYAEDGEEEEEEEDEEEDEEEDEDVEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJC6</accession>
    <name>A0ABR3VJC6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tafazzin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="54306" checksum="156B507F1E6EE159" modified="2025-10-08" version="1">MPKKRRLNRYSKPQSTAPALLSSTATRRNDNNNDDASHGRSVNDLLAQLRRTGLNGAGQAPALGVQPTVPPELRQILNIPETPPPRPRRPLRPGPGGPRLPAGPAPPRSWLSAAERADHALQRSAVPSRGAAAAVDRNHRPLPGLNLPARRSLLDMVLRRFATDWEWQRAYNHYHLYEIPTHLRVALVAYLAAHHPAGVSLRDLRAILLPPPDVPEYLQDPDLSPAIVNATFTHLDLSSSLLRSLRLKELTDFLSPPQPSVPEVQDSWDAPDPTLSLPPSILPNLTHLSLALDPSVPGTALISWRHLLTLASHLSGTLTHLSLAFWPEPSLTPRARATVAGVVSPVTGRTVAYGGTGPYSHSLDGDWSEQVLVLRRLSRALYGLEWLDLTGCGAWWRALWESVPLVDALVDDITGAGREGDGPSATAVDWVGAWGKVTTLVMFPGYRLSEEAGAAERARYWEIVDHARRVERHVRACRAGKGRFLTVETCEREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJF0</accession>
    <name>A0ABR3VJF0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="116" mass="12885" checksum="433154F62025CBDF" modified="2025-10-08" version="1">MTPTGPFKLVTVNTAPDRARRLIGRVVEDVRDRYTIIHAANAASIDEVRQTVEEAHPDVLFTASMWTPDEARQIIAIAKEIVPGLRTFSLPQGLQVEKGPDAVVEYIKEHLPSILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJG7</accession>
    <name>A0ABR3VJG7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="790" mass="85991" checksum="C5DD1A1CAEFCB085" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK86</accession>
    <name>A0ABR3VK86_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="127" mass="13237" checksum="4E82583C940B9F33" modified="2025-10-08" version="1">MQAVGHYGATCDMLLPVTGHQLLILAPWIADPARYDARRPSILPGRVLSISGFESSLTLSKSSGGSNSNRKLAVEARSGRVATVRRNRAMPVAQLRARLGDGCLGVVSKASSPQPIKPGGLCGSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK87</accession>
    <name>A0ABR3VK87_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="80"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="344" mass="38422" checksum="BB5203A14C24B9A4" modified="2025-10-08" version="1">MNRVVVALRAASCPITAASARAYASHHATTSQPSHLIRRFSARSPLFSELATTDARVKGLGKEIADEYASLRDRYEVPKYPVVLAHGLLGFSELRLAGPYLPSIHYWRGIKDALTANRAEIITTSVPPTSSIEKRAAKLAEDIEAQARGRSVNIVAHSMGGLDARYMISRLKPDNVRVKSLVTVATPHHGSPFADYLIDGIPPHHLARLYELWERVTGWEPSAFAQLTTRYMKEEFNPQTPDDPEVRYLSYGAMVKHKPPLLSPFRHSHRIIEEREGPNDGLVSVESSKWGTYKGTLLGVNHLDLINWSNRVRFTMQKWMGNPPSFNAVAFYLDIGDMLAKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL73</accession>
    <name>A0ABR3VL73_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045870974" evidence="1">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="101" mass="11002" checksum="40E5A362E1C1E0A7" modified="2025-10-08" version="1">MVKFTTILAAVAATMTGVNAFDKPCNAPYDFCGWMLSNSEFGYKDKELQDAAREAGQDWTNGTILYDSIYNCGEGGAIAWNRHCERGCNPPLNGPNANCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL89</accession>
    <name>A0ABR3VL89_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="100" mass="11400" checksum="00897293CE8E5524" modified="2025-10-08" version="1">MASQKKDDKPTAESKPEAPATEQQRKPASLEEDDEFEDFPVEGLFSPFRHWDQEETEAGAGAGDATQHLWEESWDDDDTSDDFSTQLKEELKKVEAARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLA3</accession>
    <name>A0ABR3VLA3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="425" mass="45654" checksum="EE7F9E5B89546DD3" modified="2025-10-08" version="1">MSGMDQPTSPAGAASRPATATRKRSSSGAGLLSKLPFMRSSGEHRPRSRRNTLESDPAAAASATPSLPVPSFITIPADAPSRHVPAAATAPQPQPNLLQHQVHQALQAAQHKTRRRRGSLRKVALLGRGIQRERREGRPLTIDTTLDVDPHKPTIEIVSGTPISTSGDVASMANLALDSRANRLSSSGLSSSRPITNGYANRSDTASMPDPDATPTASFPLIPTNPTSYPRRFIDTSPTISYSTTDDEDALHMARSVPSSGPIPRTTTPSLSLSSSPAPSLLRPDRASLSSGSESYSGLSSLQRRRSTTQRAKSPLALTSLATSLPQGPDADWDYSETEWWGWIILIVTWTVFVIGMGSCLGVWSWAWDVGTTPYAPPELEDDPTLPIVGYYPALMILTGVMAWVWVVVAWVGMKYFRHAQVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLQ4</accession>
    <name>A0ABR3VLQ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inhibitor of growth protein N-terminal histone-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17016">
        <property type="entry name" value="ING_Pho23p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Inhibitor of growth protein N-terminal histone-binding" evidence="10">
        <location>
            <begin position="63"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="9">
        <location>
            <begin position="782"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="645"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="903" mass="93917" checksum="8B1100F412AD5A61" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLV9</accession>
    <name>A0ABR3VLV9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="7">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="136" mass="15392" checksum="9AF51E808E698349" modified="2025-10-08" version="1">MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVESYLVSLFEDTNLCAIHAKRVTIQSKDIQLARRLRGERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLW9</accession>
    <name>A0ABR3VLW9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000033">
        <property type="protein sequence ID" value="KAL1842780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="5">
        <location>
            <begin position="114"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="4">
        <location>
            <begin position="231"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="429" mass="48103" checksum="DC671CDF54801189" modified="2025-10-08" version="1">MSLWREEMMMQDLERDSAAGKRNAGYPGLRGEPVAPAVPSIPRVATFEIVPDGAIEGRTDEPHPEMPTPQHQPAQQQQQQQQQWQPENAKVGLWIVDTRKWYPSVTTSKQLETHAARALKLIPPSTKPKILRYYHPRDAKMALASALLKQYAVARLHGIPWSRTRGNIRSDGLHKPTYVDPETGEQPVEFNVSHQAGVVVMVAVAGYRAPPEADLGLGGGRTGGGLPDVEVGVDVVCTSESRERDRAALRKVEGWAKHVDTFADVMAPGEVEFLKRRLPEELEQRKGMSVTAKDDLKLRYFYAFWALREAYVKMTGEALGAPWLAELEFRGVRPSQPMEVWEVKPGEDDDEAEGEEGIAPYEVVHDMEIWFKGERLRDVNMSLRSVGQDYMIATAVRTPSNREAAMRWRLGPYVELTLENILDFAEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLX6</accession>
    <name>A0ABR3VLX6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489:SF1">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="504" mass="55383" checksum="6600051EA3483115" modified="2025-10-08" version="1">MPAQIRILVNSPAVLGGAPLATDPLGWFKPVTAASAQPPRSRRGDLAMLRAGLDIAVEYFNLGDDAALPELTARARNWADRYFKGYPYAAKRPTALLARFPNLFNLNVEPHLRLIPRAMPLPSSSEPEGASPRELRRAERKAMNSEAFPEFAEPTLASEAEIDEIVHLHTHRKPATKPVMRVDASMLHGSGLLDTLPEFLGQLARANFETETKLATNPEAVRLELDDDEADTQPHIEMNVYAGLLKEKRRQKNREIILPGNLAVQHPVKATKTDGPSESSSSSSSESEDSGDETDASTSTTASLRANLKKRKAAELEDSDDEDDRSRSGSPPHKIRLHLHYPSPTISFYDVKRGRMVTRRNKDIRDEDPFQAFQKARAAAANKPVPVPVAEKPATVVDERPTTSASDKSNAGNKSASPRSSPVPITKIRVPSRSPDGSRSSSPDRIIVLRHPVVSRSVSPSSAQNSDPEEEAVPVASTPPKTRIKIVQRERRDAREKKLIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM46</accession>
    <name>A0ABR3VM46_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4583</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1140"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="467"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1293"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="776"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1678" mass="182421" checksum="68996A69A3E02888" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMU8</accession>
    <name>A0ABR3VMU8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="50"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="214" mass="23413" checksum="0D48EADCB90ADE07" modified="2025-10-08" version="1">MRLRGSYSAFPSFNSASSALDAPKLPPTLTDPGRSGPASPEVPDVPAILELIRELADYEHELDKVEATEEKLLETIAFAPSEPAADGSSSSSATEPTSPSKPARCLVLLTPTGTPAGIALYFYNYSTWRARPGIYLEDLYVRQSERGKGYGKRLLVELAREVVAMKGGRLEWSVLKWNEPSIRFYESIGARTMSEWVGMRVDGEGLDKLASLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN32</accession>
    <name>A0ABR3VN32_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06154">
        <property type="entry name" value="YjgF_YER057c_UK114_like_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="146" mass="16072" checksum="B35ED1E582FFC10B" modified="2025-10-08" version="1">MAENNQQQQQEQRKLVSSGSAFERQIGYSRAVVVGEWVFVSGCTGYDYKTGAISDDVAEQAEQTMRNIDAALAAAGASVADVVRARYILPDRHDFEKIWPVLQKWFGDVRPACTMIQAGLYEEAMKIEIEVTAKKGAVATEGVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNA3</accession>
    <name>A0ABR3VNA3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="123" mass="13639" checksum="A464AD8BDEC94204" modified="2025-10-08" version="1">MGHKHSVIQPSYFCPTTGTEIPTPLGVCQHCQANHDIIWQSVFVCPNTGYRVDKPSARPDKECKSCFQVHQPYSKRVFICPVTSAQIQHPRDTGGRCEKCRRSHADNSTPVGSREVVSRASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNG3</accession>
    <name>A0ABR3VNG3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="530" mass="57058" checksum="1415F10FEC4C9DD7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNI0</accession>
    <name>A0ABR3VNI0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="362" mass="38625" checksum="0C1BD024AF23A57A" modified="2025-10-08" version="1">MQRSITVKKTEGKPGEVYYPLQLNSVPIPTPGPGQVLVKVSAASLNHRDLFIRQHLYPGISFTSPLMSDAYGVVTALGPGCSSPSLLHKPVILVPTRGWDSDPNGPESTNFCIIGASTGTPAGAGTEYLVVDEQDVVLAPEHLTPAEGACLPVVGVTAWRSLVVKSGNAEPGRNILITGIGGGVALQALQFAVAKGCNVWVTSGEAGKIERAVREHGAKGGVSYREKGWEKELAKMLPRERPVLDAVIDGAGGDIVARTVKLLKPGGVIVSYGMTLGPRMDYSMQAVLKNIDVRGATMGSRQEFRDMLEFVRQHRIRPVVSRVARGLEDLEGIEALFEDMKAGRQFGKLVVVVDKEADAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ33</accession>
    <name>A0ABR3VQ33_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_623</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="408"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1843641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="518" mass="56477" checksum="98E65C4B919500DA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ52</accession>
    <name>A0ABR3VQ52_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="341"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="522" mass="59036" checksum="ABA05FEE13202EE4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQE5</accession>
    <name>A0ABR3VQE5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 7"/>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="93"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="404"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="493" mass="52896" checksum="7DEFFF83182C041A" modified="2025-10-08" version="1">MQRTRLTAVARALGGACRSSSHAAVQRRSMSRAVVSALPARQQQAQQQRQQLCRHQHAPLISSASKGPSPAIQPRRHASSSSSAPTELRKTTLYDFHLARGAKMVPFAGFHMPVQYSDQGVSQSHLFTRSHASIFDVGHMVQRLFTGPGAAKFLERITPAAASSLSEFCSTLSAILKEDGSGGIVDDTIITRLPEGVFYVVTNAGCRDKDNAYLDREIAKWNAEFASQGLEVAEDRMDKKGLIALQGPESASILSRLVLDPGKDEPLDLRTLLFGHSTLARVNLPHKSSVSSLVLISRGGYTGEDGFEISISEGETVDVTEALLEAGGPERVRLAGLGARDSLRLEAGMCLYGHDLDEATTPVEAGLAWIVPKERRTADAGYYGAEVIAKQLVPQSKGGEGVSRRRVGLLVEGAPAREGAEIVPRGEAKEETVGIVTSGCPSPSLGKNIAMGYVKDGLHKVGTEVDVLVRGRPRKAVVTKMPFVPTKYWKGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQH6</accession>
    <name>A0ABR3VQH6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="269" mass="29086" checksum="0335DDDC48BA52FF" modified="2025-10-08" version="1">MVASGLLDPITYHNYDGIYAEDCSLMVPYQWSYNAGSFLLGAAAMYNHTTRADRDVWRERVDGLLNGSSVFFGGDAGNVMTEAACEPVGLCNVDQQSFKAYLARWMAATTKWAPWTYDHVMPLLRPSAAAAAATCTGGDSGSLCGLRWTEREFDGWTGVGQQMAAMEVVLACLIQDMRAPVAEGEGGTSAGDPAAGGEDVGRSTGHEFRPVSAADKAGTWALTVLALEMSRLMTSTYVIRIITKVCESLFLKTNQPGEDVRFFFDDINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQI4</accession>
    <name>A0ABR3VQI4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="167"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="671" mass="74829" checksum="BEBA552B90008795" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQU8</accession>
    <name>A0ABR3VQU8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="388"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="523" mass="58167" checksum="A5858AC71F0A045D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQY7</accession>
    <name>A0ABR3VQY7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="196" mass="21718" checksum="82712A27FDB499B7" modified="2025-10-08" version="1">MGRVCKRLQRRVGEDEMILLVVEVEAMARLLSERGKNWRRRGMSEKEEQVGSWGSGTSGWSGQRAQRAAIGDLSGQFDSWLGKLSTWSSQWVRSGSLDEEREERENFDAALWEMVGQSRTQQLEGRDGRWIEGRPASTGTASAQQHRTSSRQHSCIGSGHNGDGAVFDPEAITVPFSGYLELRSLGIWSTNGASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR54</accession>
    <name>A0ABR3VR54_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="7"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="413" mass="44886" checksum="C69B6C2F8DCA02BE" modified="2025-10-08" version="1">MADEPTLDIDRHLRYWTMCLRSPLPYHYLSSDGNRMALAYFMVNAVAILTPPGSGRDSPIPASDRRSLRQWVLSLQQPGGGFAGSPTLVLPTDSDGQTVDSSLANLPATLFALQLLALLADDGDEGAAAAFDGVDRARTLRWLRRLQRPDGSFGEALKQLPGRGWFVGGGYDMRYCYIAAAVRWILRGDVKEGEPGWVEDFDTDALARYILSSQTYDGGFAGSSQEEPHAGYAYCAIGALALLDRPINGNPQSSGTLVANIRNRRGLIHWLASRQFVYLDPPESQDDDRSDDDDDEENFRLPQRLSDLSLTENLRHVACNGRTNKVADTCYTWWVGAALANLGLGLGSEQGDGVSDGVAPDLLLDRAGARRFLLERMAHRIGGFSKHPGGPPDVYHACFGLTALAVLGASCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRH9</accession>
    <name>A0ABR3VRH9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="119"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="414" mass="47037" checksum="BBF3A5BD65340275" modified="2025-10-08" version="1">MAATRSSKKTASSETTAKSRRKTVAKQGDTTTKSRAAVTKPAAKKTDTTKSQKTTKAARKTSRKKAASASTDIDIDAHLGPKIPDQRHLCDAEGNFLGYNLAKHHEYLEKHKPAMDTSFPQFSRLPTELRAKIWELCLPRRIIPFSAIALAYDKGVNEKDLRWPDSVFGRHLWDLLGMPCLIEQVCREARETARSLRMYAEGELNMPWLGKGSYFDSRTDTILINCDVRFHYRKAWRLLQETLEVGIYRPGGSKNRVTVGITSEYVKFKHKWELAGEVPPEEAPLPFRYRTWPIVMCIIYLDLPKEAAKACGKFGLFGEERGALIPIRKRGDLGFLHGIQQVYHHRSGDPEDLVDIYMEAFDGRKDLYLQAGYHLGIEKRDGDEEEGLTETGPYPVIFAKWKDWKSSDGLSRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRM5</accession>
    <name>A0ABR3VRM5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="116"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1844081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="316" mass="35650" checksum="DBB892080A59C345" modified="2025-10-08" version="1">MLIRISLRAPNGQSRVEIDDEAPLRDLVSLIREKAGLNNFSLKYGYPLKSLDISEPSQCVSIRELNLKGETIVVAPTDTQPQPAPPPVESQPKPFKPKAVEPDETAISWPERGGYLVLRVMPDDNSCMFTAFGGAIGLENPSKKLRDQVADYILSHPEKYNAAILGEQPLRYTTRMRQMDTWGGAIELSILSDIYNLEISSIDVKTLRIDRFGENKSNRVVIVYSGIHYDRIAFTMDLSHPVEVDETRWPVEDSEVLEKALELAQRLQQMHYYTDTTDFVLQCEMPGCNWIGQGAKEASKHERETGHSQFGELQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1J6</accession>
    <name>A0ABR3V1J6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP180 N-terminal homology (ANTH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000594">
        <property type="protein sequence ID" value="KAL1835596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP180 N-terminal homology (ANTH)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="136" mass="15958" checksum="BA37BBD555715282" modified="2025-10-08" version="1">MIREGSPDVTLAYLAKHRNMLAVSMFSDAQTQGRNIRHYSNYLSERARAYRETKIDWVRLKEPRLEKLSIEKGLLRETEVVQHQLTALLKCDVMDNEPENEITITVFRLLVLDLLSLFQTLNQALINILRHFFELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V205</accession>
    <name>A0ABR3V205_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000635">
        <property type="protein sequence ID" value="KAL1835496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="170" mass="18544" checksum="CC5873322B8D9135" modified="2025-10-08" version="1">MTGMLRPTTPRVVRERPWQAVAPETKGTSAEVVVHWKQANQFLLILHTSPPFTPVSARREIAGAAIASTTRCTVGSLRWRPEWPLVRLKVPRAVSLRFQHPALPISRPVQCGNQHVGTSHEHRCGPDASADPRRHLSWSASTNLLAPGRPGSGIKSPDACDGGTPFPSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2A8</accession>
    <name>A0ABR3V2A8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000548">
        <property type="protein sequence ID" value="KAL1835742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12319">
        <property type="entry name" value="RRM4_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="476"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="587"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="692"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="817" mass="89400" checksum="065A52DCBBCA00BE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2D2</accession>
    <name>A0ABR3V2D2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000503">
        <property type="protein sequence ID" value="KAL1835932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="708" mass="77872" checksum="4D1F21AC0E17316F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2G7</accession>
    <name>A0ABR3V2G7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5895</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000510">
        <property type="protein sequence ID" value="KAL1835911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="572"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="732"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="779"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="809"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="893"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1835911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="924" mass="102729" checksum="4A3E21DCA01F191C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2Z7</accession>
    <name>A0ABR3V2Z7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA binding protein Jsn1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000490">
        <property type="protein sequence ID" value="KAL1835975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="474"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="622"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="684"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="720"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="757"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="972"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1193"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1011"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1151"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1257" mass="133608" checksum="E9E944FCC030EA8A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3F5</accession>
    <name>A0ABR3V3F5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000490">
        <property type="protein sequence ID" value="KAL1835976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="237" mass="26773" checksum="5D2D3999CF037FAC" modified="2025-10-08" version="1">MSTMSEGEVMNKLREVVSKDDPNRFYAKQKKIGQGASGSVYVAKILAPRPNAPQFKGRSLDRVAIKQMDLAHQPRKELIVNEILVMRENRHPNIVNFLDAFLMDNDKELWVVMEYMEGGALTDVIEGNPIITEEQISTICLETCQGLAHLHSQNIIHRDIKSDNVLLDARGNVKITDFGFCAKLTETKSKRATMVGTPYWMAPEVVKQKEYGPKVDIWSLGIMAIEMIESEPPSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3I1</accession>
    <name>A0ABR3V3I1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000427">
        <property type="protein sequence ID" value="KAL1836338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046859556" evidence="1">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="244" mass="27079" checksum="B06F1F3829C3D079" modified="2025-10-08" version="1">MPIGLLVIGAIPTTIGVCEALSAQKKADAAAKEKAKFHLTATVSLDGRGPIECLCVLKDGHLWIDHPSFPVPGGHKFTGYYFTYPSEAKPLGLVSTIADDPPMLNWIFVDEETGLVRHGSRQDTLKGRTIVGPWYWSEGGEDNEKWLTLEGDAASFVAVQVGDDDDRRWAVGWDKDAGFSAGRRAATVTKGNGQETEEMIMQGQEHEATQPSRRRRRRPKWVPIMLRRRMQLGMESRYVKGENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3W0</accession>
    <name>A0ABR3V3W0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000413">
        <property type="protein sequence ID" value="KAL1836424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="408" mass="45195" checksum="CE7FB4547757AA5C" modified="2025-10-08" version="1">MAGTRELPTHADLQPYNHAVAGHDGTLSDAGGELFVKPCVQQEIDFYEKTFAEHPEFASLMPMFLGTLALNDASTVRTIDEQLPGVADHLSQGLKEEAVKRAKNALAEGHTNAEAEEAPINIGWQPNKNRRIVTDMSVVLENSTYGFKKPNVLDAKLGRRLWADDAPLEKKKRFDEISRQTTNGSHGFRIAGMRVYKGSDNPDEWDAEGFKIFNKDYGRFHVNKDNIVQAMAGFIFNERAGIDKELGRAVAQAFLHDLRRVEEVLSKSETRMYSASLLFTFEGDGEALRAAIEEHNAIISKTESAEQEEEEEFTVLNGTTELNGIEAKVLNGSVDGPIQGDLKVVELMGAPPSDSEEEEEGEMTTMPRVYSLKLIDFAHASWVPGQGPDENSLLGVRSLIKIFEELAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4E1</accession>
    <name>A0ABR3V4E1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5074</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000404">
        <property type="protein sequence ID" value="KAL1836485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="353"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1836485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1690" mass="183981" checksum="06C1D03794780169" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4W4</accession>
    <name>A0ABR3V4W4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000431">
        <property type="protein sequence ID" value="KAL1836313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="182" mass="19074" checksum="C20C3CFF33392BDD" modified="2025-10-08" version="1">MLSDQQLFNPNGDLTTKDILKKFSDRAAAGGFNAAHYAQVTHGENPTRPLPRRVETDPNTWHGQHQGQQGQLQQDREPTIPPFAAQQPPPPPGPGQQGGTTPGIRGPYEAQQHSPYGGQFDQGGPPDGGGGGGGGGGRGGGGGGGGGQGQQQQQQQQQQQQQREWRNSGWGRQNSGLTTGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4W6</accession>
    <name>A0ABR3V4W6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000402">
        <property type="protein sequence ID" value="KAL1836501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="156"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="641"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="874" mass="98415" checksum="324899FCD09F822A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V518</accession>
    <name>A0ABR3V518_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1836672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="95"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="575" mass="59666" checksum="15835F64D804226A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V543</accession>
    <name>A0ABR3V543_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4715</name>
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    <organism evidence="2 3">
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1836740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="27"/>
        </location>
    </feature>
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            <end position="114"/>
        </location>
    </feature>
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            <end position="278"/>
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    </feature>
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            <end position="67"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="101"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="271"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1836740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="407" mass="45005" checksum="0E2FCA99C236AC64" modified="2025-10-08" version="1">MPPKKDSSATPNQAPTPGGGSSTTGAMSIGNAAAAAASATQPLMTALRDAAKTVAGRSLNTNNSTAEQAAPAGGSTGPTRDGSTPPDPNGTPRRRRAARKPRTPDKATMANERNKEWESLFSLVNDGDKLADENQQLVKDGEAQLGTHLDLASKTAAELRAELEQQKASLAKALEDSEREKEEKEKRAKELAEEKRLREEAEKNAASLDQKTKDLGDELSKVSQEKEEVEKEANTLRSDKESLTKEKESLAKDKESLTKEKEILTNDKESLTKANEGLTKDKEILTNDLNAARQETQALTTERDNLQKQLATVTEELATVQEQKKRIEQENKNLQTDVEYLTLDLEDAERDLDESLKERDRYWQEKFDSFMKSLTDPEKKLIAVTKKLADSNARLEKLLKRTSAVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="6">S1 motif domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">VTJ49DRAFT_4298</name>
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    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000331">
        <property type="protein sequence ID" value="KAL1837088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
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    </dbReference>
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        <property type="entry name" value="S1_Rrp5_repeat_hs8_sc7"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAT"/>
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        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="Rrp5"/>
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        <property type="entry name" value="Rrp5_S1"/>
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        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
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        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
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        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="148"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
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        </location>
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    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
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            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
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    <feature type="domain" description="S1 motif" evidence="6">
        <location>
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            <end position="1359"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        <location>
            <begin position="1360"/>
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        </location>
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        <location>
            <begin position="1763"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1365"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1407"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1763"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1782"/>
            <end position="1792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1792" mass="196193" checksum="19A98FD5182A6361" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5S3</accession>
    <name>A0ABR3V5S3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000329">
        <property type="protein sequence ID" value="KAL1837104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046696013" evidence="2">
        <location>
            <begin position="16"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="342" mass="37996" checksum="302A8DF71848F810" modified="2025-10-08" version="1">MRLTWILAGASLAMAKPNKANFDTLVAFGDSWTDNGRLGYYINNGGKAPPPGRMHDESTVTASGGLSWAQYAARDAKAALRDYAVGGAVCSNSIVARHFAMINRTFPAIMDDQLPSFKTDIKYPALYPRRTADNTVYAVWIGTNDLGFDAFLSDSQAPGKTISDFVSCVFGVLDEIYKTGGRRFVVLNAGPLELTPLYAHPDNGGTLDSQFWRSKTQYNMTEYGQKIREYSTSVNTMYEYGLPVMAQLKRRWPKATVDLFDVHSLFLDIVRQPKKYLAPPHNVNSYYHQCEAAGSPCVDLPGSLDGYMWYDELHPSNKTSAIVAEHFLDVVAGKSKYGTRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6S0</accession>
    <name>A0ABR3V6S0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000306">
        <property type="protein sequence ID" value="KAL1837325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37515" checksum="C363EB2CB28E1530" modified="2025-10-08" version="1">MALVSRLSLTGPSAEDPEDYLASSLGVIFPDDVSNQHGDANHGLLYTSPHLPKPLAFALADVNAERDRYLFSHYLWNAALLLAELVEAGTLGLAVDGKAGEGGGLLLWDDTVAPKEGPSGLFDVTGLSTIELGAGTALPSVMAGLLGAKRVVATDYPTPPVIATLRKNVAALVREEYAVHGRFRVSAAQDGGEVRVVGHEWGKLPADGANMDEDDEDTKFTLANRHAFDRVISCDCLWMPWQHENLRRSIAWFLRDDDEGKARAWVVAGFHTGREKMAPFFDAAELAKVGLEVEYLWERDCDGKDREWVWDRGVEDVSVRKRWLAVGVLKRIRKAGGEGAEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V758</accession>
    <name>A0ABR3V758_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MRG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000297">
        <property type="protein sequence ID" value="KAL1837407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MRG" evidence="7">
        <location>
            <begin position="267"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="454" mass="49924" checksum="47E6ECB9B1A65E62" modified="2025-10-08" version="1">MPPIRNTSTSGKANSSPSKSKRIGTAAAAGMFTRSKKGATPSNTTAKGVSFANPVASIVSPAKGCPLEQFLAKHHGVRRATPAAYVTAHKGVINRQVEGTHAALEMAHGPLSDELSEFVKMEARWAYSAEAADLLMRRPNDRNSTYLRVEEGRAPCTAFDSAFTQEASSKPVPVGERHPRILAAERRGTLSTQLRAYYEHLPPKVNVPLAGTPCARAREGEGDNGEGNDGREGRNDDSSSDGNSTGSSNRLGDGLIDGGSAARPSIDDEDEDTFHSRPSVKIPVPDHVKALLVDDWENVTKNQQLVPLPHAHPVEEILNDYLAYERPHRVEGSAAMDILEETIAGLREYFDKCLGRILLYRFERPQYHSMHELWNQPDSKHKSAVDTYGAEHLARLLVSLPELIAQTNMDQQSVNRLREELVKFTNWFSRHVTAYFVSEYETPGSDYTDKARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V776</accession>
    <name>A0ABR3V776_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gem-associated protein 5 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Otillar R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000258">
        <property type="protein sequence ID" value="KAL1837848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="603" mass="65667" checksum="2A14D070CECB95C6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7S4</accession>
    <name>A0ABR3V7S4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000259">
        <property type="protein sequence ID" value="KAL1837838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="716" mass="77233" checksum="18A6EEFEAC170F3E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7S8</accession>
    <name>A0ABR3V7S8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000262">
        <property type="protein sequence ID" value="KAL1837801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="158"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="484"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="588"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="779"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="878"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="912" mass="101401" checksum="540C48DCA79AA997" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7V5</accession>
    <name>A0ABR3V7V5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein ypt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000259">
        <property type="protein sequence ID" value="KAL1837830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23829" checksum="8C8C8A6ABA738547" modified="2025-10-08" version="1">MATRGPPGARGMSNRFAQFKLVLLGESAVGKSSIVLRFVKDQFDSYRESTIGAAFLTQTISLDENTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQATSLDKAKSWVKELQRQANENIIIALAGNKLDLVTEQPDKRAVPTAEAEAYAREAGLLFFETSAKTAENVQELFTAIARKLPLDQAGPRHARPGQRPGVSLAPEGANTQAGGPCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7W1</accession>
    <name>A0ABR3V7W1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000259">
        <property type="protein sequence ID" value="KAL1837831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="700" mass="78479" checksum="25A84B63235E7860" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V832</accession>
    <name>A0ABR3V832_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000248">
        <property type="protein sequence ID" value="KAL1837969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="99" mass="10978" checksum="67AF649EA0DDDAA6" modified="2025-10-08" version="1">MCDYEEFAFTCGHSTIRLKCYCHRARNHPNHYCTFVKKLRDIWEQDGPCDACAAAAASAAMPQAQARDVWIELLEGEALMPCNGVTGVIITVDKVVTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V878</accession>
    <name>A0ABR3V878_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000278">
        <property type="protein sequence ID" value="KAL1837616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="803" mass="85910" checksum="0D91F4B97C56B439" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8J6</accession>
    <name>A0ABR3V8J6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000264">
        <property type="protein sequence ID" value="KAL1837776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="999" mass="110251" checksum="F43CECA98485A8F3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V981</accession>
    <name>A0ABR3V981_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000217">
        <property type="protein sequence ID" value="KAL1838389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="415"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="640" mass="71370" checksum="7C623049F7FA9D86" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9K2</accession>
    <name>A0ABR3V9K2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000209">
        <property type="protein sequence ID" value="KAL1838523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="337" mass="35850" checksum="46DC1AFEF508B36A" modified="2025-10-08" version="1">MSTIASPRDPGGPFPRRANSSIITPTSSTRPSLDITPSGSPNPTITSSSTTTTAAANPQSKRATRAALREYYNLRNTPQQPPPPTVQITDLLDPASSSSSSTSPFHHGGPPTQPPSELDDPSFDAEAYTARLLREGSLADLLRAYTRALTEMRALDAERKALVYDNYSKLIAATETIRRMRGAAAAAASSSAGTAGAGTEGSEEGSALVAGGGAAALDAVVERIYVQARGLREGLRERVGDGGAAATAGGEGRRDAKARTRELAREVVQVPERVRRLVVEGKEEEARREWELPRRLLVRWRELGVGGEDVGKLIEEGDAALRSPDEEEGREGRGVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9M8</accession>
    <name>A0ABR3V9M8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045403735" evidence="2">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="414" mass="42355" checksum="82882E5EDECB19DF" modified="2025-10-08" version="1">MAPFFSLRQAVLATLFFGAARTQEVEPRQILVPVGNGPVQNNAELLSQLQSAIQSMISERLNLATGVATLVTSTRRSGLEAILSQIAEATATETAETAAETAAETATETTESAATTTTIGVGRGRLGLGNGLGKGLGNGNGLGNGNGLGLGRAGRVNLNELLQLMTGRAGAGAGLGLGLGNGVGLGNARNFQDILRQVLGQGAGAGNLQLGDLQGLLQQIRERLQEVAAGLGKGKGNGKGKGKGNDVVTTTTEEAAETTTEAATETTEIVETTTTEEAATSTEEAATETTAVEEATETTATEEPTETATEDAATETATEDAATETAATEDPAETEVVEAAGFRIARRAAEPEAQNGNNTDSDNDTDGNTTDDGELTDGDLTDGELTDGNTTDDNQVARVVRPGRLSNRAARRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000215">
        <property type="protein sequence ID" value="KAL1838417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="181" mass="19570" checksum="205397F377FF86A0" modified="2025-10-08" version="1">MAQISGPAAEPESARRMLKKLASRLWNCPTLHPVLTSHLAPFFSPSTSFPLPPPFQPGKHARTAVANTQGPFLFFYCQRFPLPVDRGFCRIASLSAAIHLSRAHRRLFASSPPCAVPVAAELASRDKPDTQPCDSPSAIQQPLISTAGHTKRVPPSTCDPAVIPTLRSPLSATVRLHRIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Y8</accession>
    <name>A0ABR3V9Y8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="161" mass="17890" checksum="E53063C13A5EF0C5" modified="2025-10-08" version="1">MSTYTTSPPRVILSSFPHDPVPVSVNALLRVNGQPLTAHACFPIVPSSSGNAVVINTEKLSATLTLYIHKHGYDDNDPDAAYPTLEGAIAGTTSIGCVEPFTVTTDPEEIQIQFTWTDLQIRWPGRYRFKLNVEEYSEEDLSHGRYYADVAEAWSPWFTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Y9</accession>
    <name>A0ABR3V9Y9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2658</name>
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    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000214">
        <property type="protein sequence ID" value="KAL1838435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="849"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="918"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="946" mass="103327" checksum="A11EC38874746DB5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAA5</accession>
    <name>A0ABR3VAA5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Voltage-dependent anion channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000241">
        <property type="protein sequence ID" value="KAL1838053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="48453" checksum="932C920BF3099CF2" modified="2025-10-08" version="1">MGSTEADNPTPPSFQPHPPPPPPPPPPPLSLASTTRSTGTTSATEPHRAMSASSPGAGELGAGPRPRRERTRRRHRKSDAESTLQLDDDPAALAAPSPPTPPTPPDGDGHGDGHGGGDGDGHGACGSTGSMGVLERVPTLVQPSLPWRNRLMHFTFAWYTVTMSTAGVALTLALIPYRFPGLSYIGLALFLLDVAFFVLISAAILARFLLYHPTLRRAFTRPSEALFVSTLFLSVAAMLSNTAVYARIFLSEAKVQRLARGFLRPAFWVYLGLAFACSVLQYHLLFTVKKPARRLRVDAMTPAWILPVFPVMLAGTLAGTCATELPDPRQAVAIMAAGLAAQGTGWAVSCFMYATYLSRLMVFGLPVQRPGMFIAVGPPSFTSLALVTMAGEVPRVLEGLAGQAATERVNGRGGSSLSVWAVAAGLGEGETRALAASVQIGRGNAGPGFSFELVEFCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAE7</accession>
    <name>A0ABR3VAE7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000192">
        <property type="protein sequence ID" value="KAL1838809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046933398" description="Sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="90"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="224" mass="24527" checksum="7608914E61BB5130" modified="2025-10-08" version="1">MARRQHITLSLLAAMVFLSLTYVMTSRSGDAYSPLRVYDEKVATDYALDYGSSSSSGKSSSSSSSSSHDALSGLSDNILQGGSIAPKLENATIKAELGRASWKLFHTMMARFPEKPTPDDSLALKTYIQLFARLYPCGDCAAHFRKLLERYPPQTGSRNAAAGWACFVHNQVNKRLGKQEFDCNKIGDFYDCGCGDEDGNKKNEELKGRDGLTLEMEEGLVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAH0</accession>
    <name>A0ABR3VAH0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000193">
        <property type="protein sequence ID" value="KAL1838782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="91"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="683" mass="74600" checksum="69A1EFE7C6390DFB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAK8</accession>
    <name>A0ABR3VAK8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">GPI inositol-deacylase</fullName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000189">
        <property type="protein sequence ID" value="KAL1838860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="6">
        <location>
            <begin position="64"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="8">
        <location>
            <begin position="351"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="7">
        <location>
            <begin position="633"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1449" mass="162591" checksum="40BED9BB24BBDDAB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAV2</accession>
    <name>A0ABR3VAV2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dedicator of cytokinesis protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000194">
        <property type="protein sequence ID" value="KAL1838765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="9">
        <location>
            <begin position="606"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="10">
        <location>
            <begin position="1436"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1771"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1857"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1915"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2073"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1783"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1875"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1918"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1943"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2000"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2073"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2097"/>
            <end position="2109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2142" mass="235312" checksum="597FC71EEC6CC05B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB73</accession>
    <name>A0ABR3VB73_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000192">
        <property type="protein sequence ID" value="KAL1838802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07230">
        <property type="entry name" value="Pat_TGL4-5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="210"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="755"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="801"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="241"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="867" mass="94839" checksum="FC8C48E0A4A322BE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB95</accession>
    <name>A0ABR3VB95_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000176">
        <property type="protein sequence ID" value="KAL1839075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="347" mass="37712" checksum="C057CAF357C1811C" modified="2025-10-08" version="1">MPPQLLPASAAAFAPRASSVNVVLGSKVEPWLTQTLKRINKIKRPLNSVPQHQRCLTETLSSPNAIWTLASLLLPKAPEADLRKDSNPLVEALFNYQIIHIEAYIVHVDMVLRNEVAYKLTPETIESLIAYHKDIHCVDAKANTYDWSDKEKQCKKLHDDFVQAVNKFVFRTHVSALEGLEEDGAGELLGGKSEEVKNSIMGMFKPLLPPPPKVVDVIRQPPLLPSSPAAALWSQSPPPVSLPAPVESWKILPSSPGVASTSADSGASIWTTIGGISEVQVPSPPPALSQPYSQPYSTAGLYYSSPAVTAPMPQLPLPSMLAPCGISVGYNTFGGWDTRYQEYATTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBK7</accession>
    <name>A0ABR3VBK7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000175">
        <property type="protein sequence ID" value="KAL1839092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="166" mass="18273" checksum="EDE2C4959943A318" modified="2025-10-08" version="1">MSLFPEWLFRSVRRDTIAHSPILAIERLNSQPRPLPEEDKEVLVGAVLTMSASLNLALSMLQELLPQEQSRERLGEVLSNTVDIWNEHGICIGCSRSGHAPDLRSWSKEPSFKQTPIHNSSELPPHAHSFISGCPFTMVVIGKTTVTTASSCPTREISAGEGQPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBP7</accession>
    <name>A0ABR3VBP7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000166">
        <property type="protein sequence ID" value="KAL1839280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="365" mass="41829" checksum="CA4B675C9375D15C" modified="2025-10-08" version="1">MMSAPGRGSALLRKDLRSVHSLVTTEDTDYDPRPDSRHFYEDDSARSVHDEYPRLPPTLCHRGIYLRRDHLPTTTPQTAPNPRHYTIQAGIILTRAPLLTREQTPFENAFYLYQKRLNERLTAPFRPAFYFKPDTALDLDWRLKLRERHGVPAKDIGRYNPRGRMAWNDEVMVGSPVCDPENIREKLLADAELRVSEDGEPIPAEDRVPVERPMPRRTEADEKRDTKRLDRALDKTLYLVVKKGSGEQARWEFPCGLVTTEEALHETAARVLAEAAGVNMNTWIVGRVPVAHHVVAPEFDEATGALRNRGTKIFYLKGRILAGQVTLTKDNLRGVTDFQWLTKDELNGVIPRDLYPSVRNMFELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBT2</accession>
    <name>A0ABR3VBT2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000165">
        <property type="protein sequence ID" value="KAL1839303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="222" mass="24012" checksum="6541A517F2827ECC" modified="2025-10-08" version="1">MGHLPLNLIPYLLAHHPAYFPRVTAHYVDVSDPESVDACLSEVLAAHNSKTINGLVTSAGFTENFPAVDYPVDRMRRLWQVNVDGTYLFARAVAKHLMDRHEQGSMVFIGSMSGSIVNVPQPQAPYNASKAAVRQLCASLSVEWAEAGIRVNCISPGYMLTALTEKILTNNPALKAEWTSRIPQGRMGAPADLTGPVVFLLSDASGYVTGADLRVDGGYTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBX5</accession>
    <name>A0ABR3VBX5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000162">
        <property type="protein sequence ID" value="KAL1839349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="476" mass="51114" checksum="05252978B8666A99" modified="2025-10-08" version="1">MLAAHHDQENRYALQANAAKQQLQAKTPGARYPKTPLKVPLNDENAARGFNGKSVLGGKGNNENALTVGKGGNGLGKSGKMTMVTPAAPTVRAPLGNKTTNAKAKSAFQTPGVKPVDRDLEKTAIRPSSNRRLKQAAPHMEGPKLEVHSDKTPLEDEEVEYAPPKPQDIPYESDVFPDGVLTFDGLKPENLFKGYYRYYFNRVGDDGKTALERDMEQRQKKSFERGEEQILRDMDEFDWSIGDIPESKDLFKKKSTPPSTTVTSGKVSARPFSKQPSTIASRKAASALSMSAKSSGITTTTAAAAPKPQTKGFLLPKRKPAQPLSKPILTARNRAPAVAASRSTLGYTKGRSVSSAVHGTTTTATARSVSTSRTLSTRTATTTASAAPKPRALTRSVSTASTGSSEATITPARFANQVSSSKEVRKQLDYMAIFDADDGDETEDDGLLGGGSSPLMDEEDAEFELRLEFDDGQSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCD2</accession>
    <name>A0ABR3VCD2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000178">
        <property type="protein sequence ID" value="KAL1839041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="3">
        <location>
            <begin position="822"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="940" mass="101818" checksum="5673F33C6F5DAAB4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCQ8</accession>
    <name>A0ABR3VCQ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000156">
        <property type="protein sequence ID" value="KAL1839458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047325813" description="Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="6">
        <location>
            <begin position="375"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="536" mass="59528" checksum="D88732B8B4823386" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD36</accession>
    <name>A0ABR3VD36_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000151">
        <property type="protein sequence ID" value="KAL1839545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="48252" checksum="9FB4B1A2CC00367F" modified="2025-10-08" version="1">MATLARQPFAPVDGARLKSLASVKNRQNALASSPGKRKASEVGDVDNSENIAPVLFPKRSKGADLWGDLNGFVKPSNFTLKTTSSSVLKDVISPASNISAVSQPRAILEPKSPAARLKAKATAVSPSPRSSPAGRSPPRATKRMGILSRRRISRPDPPSFSSASIPFSLDAALKGTIPSYSGSLRTSKAKAKPSTSTTSSSAPVDFFFSTPDPKSSLWCFDIHEDTPEQEMTNLLQHSTCTLDISSDEESESRAKRDRAEGRDKENIPPPEDVSQTSLARGGPSSSRGTDAVDIDEDVLLMKGRGPLAEMNVTDFYAQGVDSSSVFIIPGDEEDPEAVVGEAEAAAKAAAEAELAALSELPPLPEDGEEERGWFATEEDSHAEQPYVSLADVDSVDVDDIMGDGGQSILEANPVEAGDENFEIWESNSAKEAASVPASPGPLVDDDVASQGDASDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDH2</accession>
    <name>A0ABR3VDH2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_1013</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="JAZGSY010000135">
        <property type="protein sequence ID" value="KAL1839925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="17">
        <location>
            <begin position="210"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1839925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="502" mass="53887" checksum="5D77D79EEB42C169" modified="2025-10-08" version="1">MTYHGGDRTVVVSAPGKVLLAGGYIVLDRKHSGLVFGLSARIHVLAQKIPTSTGVHLSEIVVQSPQFLNANWRYGYHLAPDGGGIKVTQLQSGTHVEPNHFIETTLNYVLSYIAEVDKRRASHGFEASSLIVLADNDYYSKPKESSSTSRPSSSSSSSSSSNSTNPHTRSLSAPEHLPSQTDAPVPAPTTDKPPRPRFRHFGTTLRDAHKTGLGSSAAIVTSLTAALLAHYLPPDLFDLSTPQGKRVLHNLAQVAHCSAQGKIGSGFDVASAVYGSCLYRRFSPSLLSKLPGPGEPGFGSALAGLVDGEEWDCEIGKEQVGVGLPEGVAIRMCDVDCGTATVSMVKKVHEWRDKNPAEAAEVYADVQKKVDELAGVLREKDVAGITPVMKGVRELMRGLGKSSGVPIEPESQEEMLDALEKVEGVLGSVVPGAGGYDAAAVVMRDDEETEKRVKAFLREWSAQKEIRLRLMKVKGETEGARMEDVGEFKLWIRSDGPEAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDI8</accession>
    <name>A0ABR3VDI8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046226487" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="54300" checksum="FEC1202908B56EA1" modified="2025-10-08" version="1">MRRRSLSTAALTAAVLAPVLVASQLTAGCTSNSFTIPSWVVQDFASQATSNLTVTSFNAINRATNEALGFRCLSTDSEEGWQNCSARNRTDATLPYTVAVRSEGTTAEFRFNETWSCDDIDARSPITFTAVGDGSVALTCDAASGGTTCRATKPAFIQASLSKPVSITPKYVSGPPNHSEPGCAATSGEATWEVMATQMTIQAPVAEYPRGSAFVIFRNDYLGYNALCTGQYTGTAQPATLTCTGQTAVRRPEKYQIQSSALYDPVTHDLTVNQTWFCDDEDPAEPLALTALATTKLDLDCDQLDERTIFCSGGSAPFSGTIANRQPLPPYSLNDPLSTFPSCTVASVAAPAWWLSGFQTNTTREQGESVTARFGMELLTGTTSNVRPTGFGAHIVAHGVPVPFASENVTLEELPWNECVIEAAGDWTLAPTDCEFKYQMSSRYLGVRVGWTCSDLDPESLISFRAELRTLVPALTCVTATNGDIRCTPQDTQPWRVNATSVTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDJ0</accession>
    <name>A0ABR3VDJ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ORC6 first cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000139">
        <property type="protein sequence ID" value="KAL1839826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="44301" checksum="10721800F9015B04" modified="2025-10-08" version="1">MNRSIEQALLSLLPTHSTAFPEQLTELASSLLAQSRQRASTLRAEEEIARPYACAHLACDRLKTSLNLPPIEPRPPIPPRIYKRLYTHLSQILPTAASTPSRHAPPGSALASADGRRIRTPTSKIREQQQYQQQLQASPSPLASKSVKDLSSRAELRGQTSSSSSSPSKNRTISAAATPSKVVNAEPLPRWMRPTLRFLLSNLGPASIGPVVGAGLESVVIPRGVLTDDSWVRANLPAVLGALYLFVWRGVTWPAGEGEIDRDKYIAFRKEVAACLAKARQEVVVPKGKGGKEEVDEEEWWEGWTDVGPRDLDSAAVRGGRHGWFEMNWAEGVDDLVERQRRAEGQADGEENGEAAPTQTRRADTMFQERCDYLSERKRKAYAEWKQGMLKRIRELEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDV6</accession>
    <name>A0ABR3VDV6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000129">
        <property type="protein sequence ID" value="KAL1840053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="185" mass="19981" checksum="5622A7D9B736A672" modified="2025-10-08" version="1">MFKTTIRTGAWRPRLRVPYHFPKFRGYATMQERVALSNERQWQIAAVAVTIPGLMYLRGGSSRRPEISQSNMTQRMQQVPGKVQAKVQESPMAQQAVRTITQTAPKQQFEAAVEKTEEMIDKTKEAAKEMLASAGGGGSASAASESSSGESSGVATPASESQGQSEAQAKAPEDTAARYLGIVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE90</accession>
    <name>A0ABR3VE90_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="161"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="234" mass="26642" checksum="489227CC1FCF86C4" modified="2025-10-08" version="1">MEEETSASTFAKEVTRLWRAWRTVHEMVQDRGYELAEDEVKISLDRFREEYTNADGSPNRSKMQFSARPSEAMIKKFTPPPTPSNPDPAPECGTIWVEFCPEKGSIGISVMKKFVEHCASNNFKAGILVTHAALSAQARKVMSVTSQFTLIECFLEEDLLVNITHHELVPKHILLSREEKAALLKRYRLKETQLPRILSKDPIARYLGLKKGQVVKIIRNSETAGRYASYRLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFC1</accession>
    <name>A0ABR3VFC1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000113">
        <property type="protein sequence ID" value="KAL1840439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="240" mass="26643" checksum="B0EE7AB9CD888F04" modified="2025-10-08" version="1">MSPSSPFRSNQSDHSAPSTPVSLSTTFRSPGQRPRGREANVYDAVAGRVTINVALSDSESAQAKTKRRLSVTADRYLSRNQKLAPEEVLFRRKNAPVRYAEHDIYWANEDLPDGGRRQLPDEALLRAIHGYASRFYDATAARLGPRGVVGSRIVDERSMDETALLAFGILLEEASREAIGKAGDLVFTEAASEPKMAVRVAKGTASRWAAEQPRDEMGRFVRQDVREVKRRRVVDDQTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFF9</accession>
    <name>A0ABR3VFF9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000106">
        <property type="protein sequence ID" value="KAL1840609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="70" mass="7275" checksum="FBA3ECF54A6E705E" modified="2025-10-08" version="1">MMPSSGGAVKARQLAQLHSQLAQLSANLADTENLLRMTSVQAEAMRGLGSWHAGLSVTPSDTLSLILNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG93</accession>
    <name>A0ABR3VG93_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="9">ALO</shortName>
            <ecNumber evidence="4 9">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="4 9"/>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="42"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="553" mass="62041" checksum="E1FB9F8CEDC5FAAC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGD2</accession>
    <name>A0ABR3VGD2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="209"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="545"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="880" mass="97096" checksum="639BF2CBF29343F1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGF3</accession>
    <name>A0ABR3VGF3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="289"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="392" mass="43781" checksum="A4CBEFCE2B9B071A" modified="2025-10-08" version="1">MKDACAPPPGRTVSMASKPQKPCDISNLMSPPEPAPLDSFRPSTSEGAKPGSNPESHINHQPLSPPVSPFTKAANSIGPTPPLSLGGKDPILYPIGDSTPSAPTGPLFTPTPASLENFRSTTERLVSEHIATRPAELFRHSTPPRPEDYELALYFKSNCFRMFQDNPKGWLRQERELLRADRADRKQASRSFQPAKLPPILPASRPPVLGPQTTKTPAARIQKPKSPKVKPQNPRPIRATPAPARDTIRVSTPEPRVRTVAPNREDKDFTALEDLSPPTSTLPNKPNSLKVDWKGNALDLTNDPHRHLLHPDELSLASNLRLDCATYLTSKRRIFLRRLECARIGKEFRKTDAQQACKIDVNKASKLWQAYERVGWLDIEWMRPYLERDRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGI0</accession>
    <name>A0ABR3VGI0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="343"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="659" mass="74043" checksum="BED361C1C39F9077" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGR6</accession>
    <name>A0ABR3VGR6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="333" mass="36997" checksum="6827821376E8DF90" modified="2025-10-08" version="1">MAFDGLDFSGLSNAALLARIQGRRRRPSGLDSGSFPSFNSLGDSDPLDRGNRTSRADDLGVLSNADLLGYIDRFENRRRRSPGLDDLDLDLGRGGGSGGLGTSSSSSFVRRSTTRRGGTNRNFLSRGRGLDDDDIDLAVYGSGRSRDYRDYDDSWRARDYRDYGDSWRSGEYRDSGDARLSRDYGDSRHGGDYGDSYHGDRSGLGDFSTSRRGQDIDYAYLSRPLDDELTVRGSVRGGDPGGDSGRRNSSPSRVEDPTSGSGGDIEGTVWVFPQGDPTVEWDHTGDRTLDWVLRDSPEPQGSDRTREWVMNMGSSWPVDEETERGRSWDRYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGV8</accession>
    <name>A0ABR3VGV8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleolar essential protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4983</name>
        <name evidence="10" type="ORF">VTJ49DRAFT_7540</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000090">
        <property type="protein sequence ID" value="KAL1841024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28917" checksum="ADE7DB2EFC85C8AE" modified="2025-10-08" version="1">MSSSPEYRAGKRPRTQSLPPPALPQLVAEQHTPIPPTDKDTKRLIVVLSNASLETYKASHGGTNRMGVQREEKYSLLNSDEHIGVMRKMNRDISDARPDITHQCLLTLLDSPVNKAGKLQIYIQTAKGVLIEVSPSVRIPRTFKRFAGLMVQLLHRLSIKGTNTQEKLLKVIQNPITDHLPPNCRKVTLSFDAPLVRVRDYIDTLGPNESICVFVGAMAKGPDNFADAYVDEKISISNYSLSASVACSKFCHAAEDAWDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIH9</accession>
    <name>A0ABR3VIH9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045124064" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="69"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="489" mass="51802" checksum="2413AAD8ADF4CC1B" modified="2025-10-08" version="1">MAASILYSSALALLLGLVRHVAAVVPVLQTTTHDEGCIHLPIVHSTNVNFFSNKRGVQLQLANRSDIAYYAQLSIGTPPQPVFVQLDTGSFELWVNPDCSTVRGADALFCERIGQYDTSKSSTVTSLGTSKMLKYGIGSANISYVTDTITLAGTSTALRNVQFGVATSTSDAFAGILGIGYGMGIATKYPNFVDQLQDQNATRTKVYTLALGSKDAREGIIVFGGVDTAKFAGKLARLPIIPAERSPDKVPRFWVDLKSITLTPPSGVGRVYEDSARPVFLDSGSTMTLLPRNLTAAIAKDFGADEPDANGFYRIDCALTKMNGTLDFAFDGVTVKVPYKELTREVPTNPPMCFLGIMASDKFTLLGDTFLRSAYAVFDLETNSIWLTQAANCGSAPAALNDINSLSLIRGTCGPATEPAATVTLPSSAVWISVADGAGESDLAGPGGRDDVRSIVAALGKRCGDGERFGVAGRAASGSWYMFVGMMCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ02</accession>
    <name>A0ABR3VJ02_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000067">
        <property type="protein sequence ID" value="KAL1841678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="579" mass="63410" checksum="33A7E625917C40FE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJB0</accession>
    <name>A0ABR3VJB0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015:SF22">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48955" checksum="96A09965478EB5C1" modified="2025-10-08" version="1">MTQINKPFIVAAAFNASGHTAGLLRISEHLVSRGFPVRFIVGSDFKASMEKIGAEFVENPWRWESVVATKPPEAGQDWIFKHVFGDTTPIAHQILKETLESIRREHPNRQVIILHESMAGAVGPLVYGAPLPEGYSSLPPVINFHPSIYATQHERIPPFGPGFRYDPTPENLALWKTTYEAMEPAMSGVVAYYDGLYKSLGATRPVTGSSPLDVTMHLGDVNILATSPSLEYLIPVPNPKLRFIGGMPVKPLDPAYVYPDWWSTVTTNAALSASSPDKKRVVFVTQGTVHRDYADLILPTLEALADRQDILIIATLGARDASLDEPTPSNASIAEYLPYEAVLPYTDVFVSNAGYGGVMTGVMHGVPMVLAGTVADKAEVCARAEYAGVAVNLGAQRPSSADIRAAVDAVLADDKVKRRAMELRRENEGLDALGTVERIVKELAARDGVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJI2</accession>
    <name>A0ABR3VJI2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="147"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="406"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="455" mass="50149" checksum="0FEA691031061B45" modified="2025-10-08" version="1">MLPSRGILRSNPVLGLARTTLPKTSPRPFPRHFSTALQSNRVALHGASTARRIGGPLALSAASQQLLALRQVRNASTQSTAPPAASADPSPLPDVSATPLELSGSDLLNIPEQIGFLKALGLDFGWGPTSLMQTVLESIYVYTGLPWWASIAAVALAVRLVLIKPQINASENALRYQKLSKDPRYIAAMEEMKYNMIAGNHLAAAQSRAKVQMMNKEGGYSMMKGFIPLLQLPLGIGMFRLVKGMSALPVPSLETGGMLWFTDLTIADPYFILPVATGIMMSIGMRIPLPFMAEQQQKMMRMMSLVVIPLSTVVAVFLPSGITWYFLVSAVLHTVQTWLMHQAWFRRLVGLRPLDVHVPRGAADGTWQAPRIVNANAPRVGHAVYAPPRPTSESMFDSLKKTLDDAKKAMNERADRGEAERARRAAQEYEQKRSLEEKEQLLARIEKQSRRGRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJY0</accession>
    <name>A0ABR3VJY0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000067">
        <property type="protein sequence ID" value="KAL1841675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="594"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="657"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="786" mass="85770" checksum="0CCA5EDA7C866012" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK52</accession>
    <name>A0ABR3VK52_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="2"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="371" mass="39233" checksum="B29452BA58506F69" modified="2025-10-08" version="1">MLSSTVNLVNTIVGAGTLAMPAAMSHFGVTLGVLLIIWCGLTSALGLYLQARCARYLDRGTSSFFALSQITYPNAAVVFDAAIAIKCFGVGVSYMIIIGDLMPGVAEGFGSVDEGLDFLADRTFWITAFFLVFIIPLSFPKRLDSLKYASMVALVAIGYLIILVVYHFAADEIPNDRDIRLIKWEGPVAALSSLPVVIFAYTCHQNMFSILNEIKDNSPGNIVAVIGSSIGSAASIYIVVAIAGYLTFGNDVKGNIVGMYPPSVASTIAKVAIVALVTFGIPLQIHPCRASIDAVLRWRPKGGQRPASVGSLPGNQPLLPSAATPVVADSHGAPPAAAMSELRFALITSAILVLSYITALEVSSLDRVLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKA8</accession>
    <name>A0ABR3VKA8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="104" mass="11828" checksum="8A49D03A68E496ED" modified="2025-10-08" version="1">MIRPFNRETTPEMSSDEGAGTPKHSKGLGIADAIRTLKAKREQRRREEAHANTLASLRRWEMLQITQGTATRGDEYFDDTDYCSCERLKMVAQMDFGSDELAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKF4</accession>
    <name>A0ABR3VKF4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="860" mass="95594" checksum="E252CC8E7C93088F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKN6</accession>
    <name>A0ABR3VKN6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="373"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="485" mass="51700" checksum="E0D85303C6F889DF" modified="2025-10-08" version="1">MGNSPSTPKTSPSSSSQAASQLDQTVRRDSGNPIPVQRHRVSAPPEPSLTQAQDTAVQPQSSTGPGATTTTASRPKLLPSSHQHSRHLGPGSAALSGSPAASSSSAGSAKPLEVGKQGRPSDPSYEPAKPVAVPNPHINSSSPQTLSHPSPRDSDGYDAAAMAHNSLQDAAYLTRPPRLPLPIEEEVHTPGSPILTAADVTEPLDDVDGLDSAGLNQPTSNLSDTSMLEEEDAEELLVDKTRPTVPTRLVWRHGGEKVYVTGTIFQWNRKTRLHPVEGQPGVFATTINILPGTHHVRFLVDGQMQTTPDYPTTVDYANNLVNYIEVAPLDQAPAPAEAAEATSEVKSAQPQAPAEDATPEEAAAEAPAPKYRDVPRADEFRQKIPQYLNDLDQAEDSPAYHNAIMATERLPNPPALPGFLSKPILNVTATRKDDNSVLPQPNHTVLNHLATSSIKNNVLAVSATTRYKGKYVTTIMYKPTTTEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL25</accession>
    <name>A0ABR3VL25_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34091" checksum="FB7558EE9BF974BD" modified="2025-10-08" version="1">MAGEKKSRRQGDDSHVAQAPDATGNGTAAVTTAKDAGDDIPHENIFLLWPNIIGYSRIILAIASLYYMPLHPRTCSLLYSVSCLLDALDGYAARHFEQSTRFGAVLDMVTDRCTTSCLLVFLSSAFPRWAILFQGLIALDFSSHYMHMYATLAMGGTEQSHKNVDKSRSRILSLYYTNKTVLFTTCALNEAFFIALYLLSFSSPLLSPSLLQSADPSTAQAVMHHGAQVNSSLLRHLFANPHSAAALELARANKMDSFWPWVFAGVSFPVMALKQVINVVQLVKASKWLAEGDVRMRRAQGLPRKRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLB3</accession>
    <name>A0ABR3VLB3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36724" checksum="4597C5C5E3DC4827" modified="2025-10-08" version="1">MPHKHTRREKDESTFDLPPTQIARPLPPTTISKNKTAAKKAADKKAIDATKKTGQKRKRGAKDPDDAPRAFKRLMALTEGKIPRNNLDNGDAPSSGKGNKKKAKTATTSTTSETPSKEELKIRPGESLAEFNRRVDAALPVSGLAHKMVKNGKDPLGLKVWRTLKERKMHNMYAEWREMDRKIRERREEEQELEEEREMEREMELGVSWKLELEGAEGAGGKKKKNKKKGKRARYIGEEAGPEGDPWEEVKKRRGEGKVGLNDVAQAPPELKLPKKTLIRGATVQVENIPKSAGSLRQREELQNIRESVVASYRKMMAERRPAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLP7</accession>
    <name>A0ABR3VLP7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="151" mass="17167" checksum="250EC1459DF8F490" modified="2025-10-08" version="1">MSTAARRRLMRDFKRMQTDPPAGVSASPVPDNVMTWNAVIIGPADTPFEDGTFRLVMHFEEQYPNKPPSVKFISQMFHPNVYATGELCLDILQNRWSPTYDVAAVLTSIQSLLNDPNTGSPANVEASNLYKDNRKEYTKRVRETVEKSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM22</accession>
    <name>A0ABR3VM22_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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</entry>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Grimwood J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="147"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="482" mass="52645" checksum="7FE96882D30BE74A" modified="2025-10-08" version="1">MPDDLVRPLIHGRSFSPAPTFEDRGVMTNIDLSGGGARRKGGKVSWVVWLSYGVDWFILIVFGVIGYILGKITPNKRPFSLDDRNIAFPYTVNETVPVWLLVIVGILVPIVIIAVICLIFVPGATVPPGTPKSLIWKRKLWELHTGLLGLGLSVIAAWFITNGMKNLFGKPRPDLLSRCQPDLDNLEKYIIGGLKNLQGVTLSGQLVSPDICKQDDKHMLNDGFRSYPSGHSSSSAAALIYLSLFIASKFAITIPFVAPAGSADASQFTAFPSRTRLPDIKVTGPDTYELSSRGPGADPVRSTTIDSALGNKGISRHNQKLLAVRRQAAAPPIYLLCIAVIPFFGSVFIAGSRWWDFRHHGFDILFGYLIGTITAIYAFRYYHLPISHGAGWAWGPRSHDKAFWAGVGSFSYATDHLRGEYRAGDEEEALTGVEETFARNTGAVHNFSRPHHDAGAGTPPTVSRKGTGIEEEDTAYLGAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMT4</accession>
    <name>A0ABR3VMT4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable beta-glucosidase btgE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_3351</name>
        <name evidence="14" type="ORF">VTJ49DRAFT_4838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1843037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="517" mass="54170" checksum="D18CDCAF2072303B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMX5</accession>
    <name>A0ABR3VMX5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="100" mass="10220" checksum="CC359A2CC59101B8" modified="2025-10-08" version="1">MASQLPQDNNPRSGLRSNAGMAGSTQTPANQHLGQDKPGVFDKEGPIGKQFTPEGAIGGAAQKIGGPLDKEGMIGKQFTPEGSIGGTVQDTLGGMKKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN62</accession>
    <name>A0ABR3VN62_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="256" mass="27025" checksum="2C19B664C8EB7AB9" modified="2025-10-08" version="1">MAKTILVTGAAGGLGKAIATAFLAAGDNVVICDVNPQRIASVEEEWAKSYAGRFLTKQADVTDETSVQGLIDAAASQFGRLDVLVNNAGIMDGFEPVGAISKEKWDRVLNVNLNGPFLTTRAAIAQFEKQEPAGGVIINIGSIASIHGFKSGAAYAASKAALVALTKNTAGYYGDKGIYCMALLLGGMDTNITDAFAHGLHMEMFQKVQASQTPFTPERSVPLESVAKYCQFLTDPEIAPSANGSCILFNKNWPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN95</accession>
    <name>A0ABR3VN95_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="149" mass="17072" checksum="C79CEB5F33FBC83F" modified="2025-10-08" version="1">MLTKTEFQKIYAQFFPFGDPSTFADYVFNVFDTDKSGTIDFKEFICALSVTSRGKMEDKLDWAFQLYDIDGDGQISYDEMLKIVEAIYKMVGSMVKLPEDEDTPEKRVKKIFRMMDKDENGSLSIDEFKEGSKRDATIVSALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNA0</accession>
    <name>A0ABR3VNA0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="220" mass="23898" checksum="D60B72A72F8F21B1" modified="2025-10-08" version="1">MAPPIVTTTVQATILSVISNLLAQAITAHQSNTPFTIDWITVFQYSLFAALSTPPNFLWQGFLESTFPAFPTSSSSSASKSKEPNGTDAKTTKQEPRLSKRNTLLKLLLDQTAGAAFNTITFSLFIHSFRQATAHHYSPASSSSTGTSTGLFRPSAVSWTPTWTASRAEFWPLVRAGWRFWPWVALGNYVFLTSVEARSLAGALAGLAWGVYICLVTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNG0</accession>
    <name>A0ABR3VNG0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytokinesis protein sepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="59"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="938"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="769"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="518"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="821"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="852"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1339" mass="149406" checksum="801D53164B3A6EFF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNS7</accession>
    <name>A0ABR3VNS7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="968"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="847"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="882"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1138" mass="127363" checksum="1EA778A5FE7BE12C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPH8</accession>
    <name>A0ABR3VPH8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="483" mass="52036" checksum="29B89BE201F62198" modified="2025-10-08" version="1">MATTHGLNGEGQQDDGERKWSTPLAKQLAEAIETTGPIPLASYMRMCLTADIGGYYTGALGEGRDPFGRTGDFVTSPEISQVFGELCAIWFVAEWMAQGRKTSGVELIEVGPGRGTLMDDMLRTIHRFPAMAKSIDAIYMVEASPDLRMVQKNLLCGEDAPMTESKAGYHSVCKYGGLPIVWTETIKSIPIGPEKTPFIMAHEFFDALPIHAFQLVSVPATQSLPRAANDNSAPSTKTSHPTLQWREFVVTPTPPGSTHDSLNTPPTQSRLFPPPDFQLTLSPTPTRHSLYLPELSARYRALKSTFGAGALLEVCPDLALYAADFAARIGGSALRPKPNPSGAALILDYGPGDGSVPTNSLRGIRAHRRVSPFSEPGLTDLSADVDFAALAEAATRASEGVEVHGPVQQADFLEAMGIRERVEMVLRSGKLTPKQEKVVKGAWERLVDRGPGGMGKVYKALAILPENEGRRRPVGFGGDLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPT3</accession>
    <name>A0ABR3VPT3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_373</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="509" mass="56179" checksum="A1B5BED63B71791C" modified="2025-10-08" version="1">MTALQTLLRGSGSASVRAAVVASRVSRPHAASRRCFSVSPRALSSFYPNWEPNGPTVKTEIPGPKSRDIIADLDKVVDTRSLNMLTDYTKSSGNYIADPDGNVLLDVYAQIASIPLGYNNPVLRKAAATDDMISGIINRPAIGNFPPHDWAETLRSGILKAAPKGLNQVFTAMAGSDANETAYKAAFMWRRQRDRGGPDVDFTPEELSSAMENKAPGSAPLSILSFRTGFHGRLFGTLSTTRSKPIHKIDIPAFDWPQATFPQLKYPLDQHAAENAAAEQAALQEVDHLIATHPQPVCAVVVEPVQSEGGDNHASPAFFRGLRELTKQRGVLLIVDEVQTGVGATGRFWAHEHWDLPSPPDMVTFSKKAQAAGYYYADPALRPNKPYRQFNTWMGDPVRALLFRAIVDEVERLDLVRHTAKVGEYLYGRLEELAKRYPGEFQNLRGKGMGTFIAFDNPRRDEFLRKAKTLGLNIGGCGESAVRLRPMLVFEEKHADILVEVMEKIVKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPX0</accession>
    <name>A0ABR3VPX0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase C-terminal" evidence="5">
        <location>
            <begin position="227"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="384" mass="42806" checksum="FE2BBC90EC7FA3E7" modified="2025-10-08" version="1">MKPTANQTLRYPPPGQVTFPVGAVLLRREIRDLQNRFPDQFSLYILSLKRFQAQDASAWNGVDITTNWSTIGAFWGYCTHSSILFATWHRPYLAFNVDRLLAIWQDLNPNADMSPSTRTLGYAYRETQSWLYFNQPERYRAIIRANVTLLYGGNVFTNFLENVANRREEHAREIAELAKKRAGAEEEAPQEAGGAEKIPADQKPLFGVEGPIPDSLKHLAPNNTYIEWVVNVRAVKHGLGESFRTLVFLGDYDASNPADWTTEFKCVGRVSVLARDSSETGQCSKCKVDAADGLLVSGTVLLTSALLQDIAEGDGLASLDPEQIVPHLKERLSWRVTLSNGEEVDPTTVPGYKVSVVSTKATIGDDGLPVYSNEYTVWGRDYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ60</accession>
    <name>A0ABR3VQ60_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_394</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="36"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="870" mass="94250" checksum="7A85026E6B6B4013" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ71</accession>
    <name>A0ABR3VQ71_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="875" mass="94720" checksum="9BB8811EDE8764EF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ88</accession>
    <name>A0ABR3VQ88_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Carbon catabolite repression protein B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Deubiquitinating enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin thioesterase creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-hydrolyzing enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin-specific-processing protease creB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_105</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1843724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="170" mass="19555" checksum="5A4309A722247EC1" modified="2025-10-08" version="1">MSGFLQKLKGAGSGAAKPDGTALEIHAIAIRFFSAEEMLCEKNKFHCDHCGGLQEAEKRMKLKKLPKILALHLKRFKYTEDYSRLQKLFHRVVYPYHLRLFNTTDDAEDPDRMYELYAVVVHIGGNAYHGHYVAVIKTKDRGWLLFDDEMVEPVDKTFVRNFFGDKPGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQJ6</accession>
    <name>A0ABR3VQJ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="100"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="471" mass="50473" checksum="9BFFCEBDE0EC9C21" modified="2025-10-08" version="1">MSTVTCLGPASLTDTSSFYLTVAGTAVATAATLAVLRAALWPVPPRLVQSPLRTVLPKLSKHEITGLAYGPGSFPGARDVETPYGSIRVYEWGPLTGEKVVLVHGISTPCMTLSKLAYSLVEEKGCRVLMFDLFGRGFSDNPSDLPHDARLYTTQILMALASSPHLSWMGPQAFKLVGYSLGGGIAVHFAATFPHLISSLVLLAPAGLIRPESFGRLTRAIFTSGLVPPPLLERLASRKLREPIQADGRRRVSSTGNTTPTPAPTPASSSSSVVHVIGRVNGHANGHPNGSVNSYVNGNVKGHANGNVKGHANGHLNGHANGKPNGIINGTANGHHHHHHHHLSNGHPLPHASSDPTITVQEQVSRAVHWQLDHHPGFVPAFLSCIRHGPLLSEHAAWARLAAVRAPGTTAVILGSDDDLIDLEEYEQDALPLLGGKEHVRWRVIRGGAHDFPMSHARETLREMYEAWGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQJ8</accession>
    <name>A0ABR3VQJ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase B complex non catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="118055" checksum="9967FE0D2402271D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQS1</accession>
    <name>A0ABR3VQS1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="71"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="262" mass="29416" checksum="728754AF0E0CD70C" modified="2025-10-08" version="1">MAAPIDQRIAVPIDDPNADTEWNDILRKHGIIPEKPPSPTPLIEEAMLEARRIAHENRLEGKDLSDLDELEDDEDEAFLEQYRQKRLRELASLRERSAHGSVYPISKPEWAREVTDASQSGPVLVNLTSSQAGNVESRVLSALWRQAAREYADVKFCEMRADQAIEGYPEKNCPTILVYNKGDIVKQVVTLALVGGVRMSMLDLDKILVEVGAVKDNDMRVLKRRREAEDAEEEKPASSIRVGVKSGKAGRGKQDDDDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR02</accession>
    <name>A0ABR3VR02_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="180"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="584"/>
        </location>
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        <location>
            <begin position="600"/>
            <end position="639"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
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        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="681" mass="70270" checksum="53FED138A9F88675" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR65</accession>
    <name>A0ABR3VR65_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="439" mass="47774" checksum="340D65B5BA53FAE9" modified="2025-10-08" version="1">MNGAHANGLPNVGERSLNAAWNNWATMFGHQDPNRLSSGLHPLQLKELCDAVKGFVRTTENGGLPAELVSGGSAAISTLLNGMLAHYICAEIIKSPMWVFVATSIGTLESPSIPPPKPLPYLPPVAFRMDMTNFGDVAPLRPVPGPTPGSPQFPPPLITSMIPPFASGASFLGLPLKHDMERLVHIITDAQEETARISAHQWRAHLMRLLMDGGFGLKDVAAAGKGDTRRTFVESRLNYTRKLRERFLGGAARYLLQDQDSLGIERLEGMLTDMIDDALRFSCRLWTRLVPVRLQTWNHLENKEFLSPNHLVTLCHAQAPGPRKNGGQEAKEKPNGPPRDDQEGRAITMIVQPAIVTDTKDIPGHDKGKDEEVLVWLRARVMVEGPLAPDSPADFPSRGDGLQSKTPSPQTFTAPLSQSSSPSGPETVVDVLPPSSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR71</accession>
    <name>A0ABR3VR71_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VTJ49DRAFT_1576</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="19">
        <location>
            <begin position="389"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="913"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1465"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="519"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1683"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1761"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="616"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="819"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1711"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1769"/>
            <end position="1783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL1843466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1783" mass="199413" checksum="9B72BF1DA5C26160" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR99</accession>
    <name>A0ABR3VR99_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02660">
        <property type="entry name" value="Peptidase_C19D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="182"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="517" mass="58454" checksum="FA07015384CDFD14" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRK5</accession>
    <name>A0ABR3VRK5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cenp-O kinetochore centromere component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34560" checksum="1B3D7EC0B15FD7AF" modified="2025-10-08" version="1">MAASLDDEIEELQAKVASLKKQLGIHMTTLLTAKSTRQILLEPPHPTTTLTLPRRSNASPVAIDEATKLKLLDQSDLQLAHNQECLYRACATVTTFRARDPDPRAVDGGAILGLRIDVVSRTKFLRPYYVLFNRPYSGAYAGRYLRVHRHTLPPCIPLAGLAARYLPAPPKDDSAGPAKQQDLARFAHALRREVVRYHHRLGVVADLRKAAGLARRRKDAEGGDEDGEEDVEEHDKPPTATTQLVDITPADAEAKQLTLEWTDGRVGRLVMDDDGEIVKLVVLGENGRDREAGRDLLGGATRVEDVVRRLAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRN8</accession>
    <name>A0ABR3VRN8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroin-3 related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="54505" checksum="C25DE243D49F70EF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0R9</accession>
    <name>A0ABR3V0R9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000706">
        <property type="protein sequence ID" value="KAL1835364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="360"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="288"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1835364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="657" mass="72746" checksum="87C5C44CD8845C99" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1I6</accession>
    <name>A0ABR3V1I6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000655">
        <property type="protein sequence ID" value="KAL1835457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="9">
        <location>
            <begin position="152"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="8">
        <location>
            <begin position="484"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1835457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="736" mass="79352" checksum="A15A207B4723B492" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V249</accession>
    <name>A0ABR3V249_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000607">
        <property type="protein sequence ID" value="KAL1835556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="443" mass="47565" checksum="EFBB2AF90DB8A556" modified="2025-10-08" version="1">MADSCLRDWPPALSDLRLACEECHKRKIRCEASQDGWQGACQACRASNRACLFSLKNKTGRPRKPKSTHLYRGTKTLSPRSLSPKSLELQAGTGLSAAAITGPHPSELRHDWPSSKTRQHVAGHQPSAPGHYETPPYDIGSPPSGETSLGQLTWLPGIATGRSDSDPLFDSPCGGDIHVSMSPGFVQLGDDFALEIPGVMTSHPDLHDSNCNDRRGSEIGRLGRPYTIASGTTSSTGESSDRGDCGDPWRTGPGRNGPDVLGNNRDSTMSQDFSDTIRLCGEMNNGFQSRVLDVTAPADKQELSIVLANIEELGHKTVAAMRDAAVQSAPTSRQEQYKRMLTNVAVLGAVDIAADLVKHNLSIHNISYSAECEAMNDRNPDFLMADREGIPDDGDDGVCINPSADALESVLSLVRLDYALLQFSRFLSANQSEGDACHAVGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2D0</accession>
    <name>A0ABR3V2D0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000503">
        <property type="protein sequence ID" value="KAL1835933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28813" checksum="316EE9193DBE93CD" modified="2025-10-08" version="1">MSAGAGIDTFNIEDPSAITLIKTEAYNPPGDNQAAPQDVARPHQAVLDPTGDFLVFPDLGADELRVLKVNQVSLEHETKEGFVYPPEERGTGPRHAAFYKAGDKTFLYVACELKNLIQGFSVEYTGDDLKLTRVFNATTHGDDKALPKGTAAAEIYISPDGNFITLSSRNEKSLEFTLANGTTVPSDPLITFKVDQESGALELVQVAPAGGVNPRHFSFNNDGTLVASAAQADSRIVVFERNVETGEIGKAIAEANVEGNPNFVIFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2F3</accession>
    <name>A0ABR3V2F3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000514">
        <property type="protein sequence ID" value="KAL1835895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="188" mass="20576" checksum="9DEB9B8D3C6B28BF" modified="2025-10-08" version="1">MVVYSFYIFDRHTECIYSKSWLSPAPTSSSSTTTTTTPSGPTSDTHPPLPSSTTTAAPTAAAGTTGRRSAPTTSASSAADNDAKLIFGTVFSLRNMVRKLGGEDDAFVSYRTAHYKLHYYETASNLRLVMLTDTATLSMRNVLHQIYINLWVEYVVKNPLSPVEHKGGAGVRNELFELGLEQFIRGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2N5</accession>
    <name>A0ABR3V2N5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000476">
        <property type="protein sequence ID" value="KAL1836039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="3">
        <location>
            <begin position="125"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="431"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1081" mass="123429" checksum="F147EFF4C4EBF64B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3K6</accession>
    <name>A0ABR3V3K6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000452">
        <property type="protein sequence ID" value="KAL1836177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="54119" checksum="6BC0AF2BB435519D" modified="2025-10-08" version="1">MGAPPTDQLLTALDEKCPPPSGTTSTNTTVDNVNTIFNRSVEPPAGSDIKPTTTTGDPHTAAHNSPRNGARPTSKRSKLPFLIFITLTQLVQTIPLGAGINSGLAIGASLGASPVASVWVVASYPLTQGTFVLIGGRLGEIYGHKAILTAGRKRRNLGMALFGAMAPVGAAGGSLVAAVIVQLLHWKWLFFLLGLLGSVVYGVAIASVPADEPVDPKGRVDYGGAYLGVGGLILFNFVWNQAPIVGWDTPYIISLIIISILHSVLFCYWETRVANEPILPFNIWNAPSFGILIIIIFFSFMSMGIYFWYMDIYMQTIPGDSLIQTGVQYLPLTIGGTINSFFAAWLVPRVPAQVIIGAGCLATVTINVLLATIPADLTYWAMAFPAMLLSAFTIDLVTTSAQIITSNTVPMKHQGAAGSLVGTLLAYGMSTGLGFAGTVEVNTFEDGTSLLRGYHSAAYLAVGMSGFALLLCCFIRIPKDTREGWAEDDESCCGKGTSLTLSLCEGIAVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3N8</accession>
    <name>A0ABR3V3N8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_5263</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000426">
        <property type="protein sequence ID" value="KAL1836345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1942"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2600"/>
            <end position="2754"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2942"/>
            <end position="3108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3190"/>
            <end position="3266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3416"/>
            <end position="3471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1836345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="4375" mass="493806" checksum="B8158134CB6F1D21" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V442</accession>
    <name>A0ABR3V442_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000475">
        <property type="protein sequence ID" value="KAL1836043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="353" mass="38511" checksum="F874078221DB18D1" modified="2025-10-08" version="1">MPDLLVEDGDAAEGTAQPLGVVLLELGVDRLEEGPDEGHLPSRARDRSLVPDVRDCEREGGLSAKGPGPGETGELMAQLTLVIGDEDGENSRKDCPGAGVGEIFDEGFDLGRDIDGAKFNGRQRRGGRVGSHCASWWWWRSRSVQTVVLVESLQNTEDEDRTGAPENNKEEKRKRRRASAASSKARRGQQEHTHTSRTHTGLKVEKEVLWEGAQQGTGRKEKRKMECCHGVCGPQRQGVERSLPRARDRKVSKRRTVSEAWKLGCATHVTAGVSGRIWESSTIPTLLPLACGLLGLGWRGARQNLSGSSVCSMARSWGLRSVMQSIPTRLSDEPSPSLLKPFPGRIQQQEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V487</accession>
    <name>A0ABR3V487_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_4920</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000396">
        <property type="protein sequence ID" value="KAL1836559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047129194" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1836559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="247" mass="26615" checksum="AD14741D53F606BA" modified="2025-10-08" version="1">MKLSLTTLLASALSVQGHAIFQRVSVNGQDQGSLTGLRAPTHNNPVQNVNSQDLVCGAPGSRSQSVINVNAGDRIGAWYQHVIGGAQFPGDPDNPIARSHKGPISVYLAKVDNAASANHQGLQWFKIWHDGFDTSSRRWAVDTMINNNGWVYFNLPQCIAPGHYLMRVELLALHSASFQGQAQFYTSCAQINVQQGGSFNPAGQTVSIPGAYQANHPGVQVNIYGAMGQPDNNGRPYQIPGPEPIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4T8</accession>
    <name>A0ABR3V4T8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="9">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000366">
        <property type="protein sequence ID" value="KAL1836788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="11">
        <location>
            <begin position="928"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1656" mass="182360" checksum="679A724496295C23" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4X4</accession>
    <name>A0ABR3V4X4_HUMIN</name>
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        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000428">
        <property type="protein sequence ID" value="KAL1836328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7923"/>
    </dbReference>
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        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
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        <location>
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        <location>
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            <end position="282"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="521" mass="57771" checksum="5B7CDC6CFBEF3A8F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Z5</accession>
    <name>A0ABR3V4Z5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000361">
        <property type="protein sequence ID" value="KAL1836828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="392" mass="42922" checksum="E9BE82FB1F2B53ED" modified="2025-10-08" version="1">MSSHTTLAAASDDRKARLAKLKSLKRKQPSEEQEPTFTSATSPAPADDQDATNQKPSDDNNNNNNDDDTETRTSPHTPTQDVARLHLSGRNYDFETKGPKLGFEAPPILEQPTLEEKAAELERKAKEAAATAPADNTLDLKTLRPKKPNWDLKRDLDQKMQVLNVRTENAIARLVRERLAEKKRGAEAARGVGASADGGKDGQKDGGDAEADGMLEGAAMVERMRMREREEEEENRREREAEDAEFGMAGHVLVPARPTSPAISSAISNARVSPRSLPRGLFVQAKANRNVAVGDHRVRVEEVWQNGEGRATVKRASPYWDKHAQGILSGRGSNGRASRMTAPAPKGAGVKGYEGDLRRLDRDRLRSDLSSSEASRSRFRAFSLSASRLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V532</accession>
    <name>A0ABR3V532_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000355">
        <property type="protein sequence ID" value="KAL1836879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
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            <begin position="537"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="605"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="79031" checksum="72FF521AFC316373" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V548</accession>
    <name>A0ABR3V548_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000414">
        <property type="protein sequence ID" value="KAL1836418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68037" checksum="16A493858EB93E73" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5U2</accession>
    <name>A0ABR3V5U2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RDRP core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000326">
        <property type="protein sequence ID" value="KAL1837129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="440"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1509" mass="166496" checksum="938BA7FFF3E7A57A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V608</accession>
    <name>A0ABR3V608_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000334">
        <property type="protein sequence ID" value="KAL1837055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="140" mass="14089" checksum="8BB4DE75FD8FD96B" modified="2025-10-08" version="1">MEAIQTHPSNAAQAKAFTAPGSLSFPGGANEIANPAPQQSGAANNGAQQQGVQATNGSGVTPATPAATPGAGPAGPSGITPTLQNIVATVNLDCRLDLKTIALHARNAEVRVESGTHHIMFDTWSHGFLSSTVSPQAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6E2</accession>
    <name>A0ABR3V6E2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000309">
        <property type="protein sequence ID" value="KAL1837305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="891"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1095"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129113" checksum="FC08709A65C16CBD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6V2</accession>
    <name>A0ABR3V6V2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000323">
        <property type="protein sequence ID" value="KAL1837151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF125">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="30"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="481" mass="55794" checksum="7C7FDDC8733F1F33" modified="2025-10-08" version="1">MKSATLRWLRHVLWPSSGASEGQRQLRPTAYLDGLRGFAAFLVYVQHHEQWVHALYNHSLENAFGWGGHRYFITLPYVRNFFIGGHMAVAVFYVISGYVLSVKPLALIHDGEYLRLFDNLASAFFRRWFRLFIPLIATTFTTVTLWSIFGVFNPHYELKSTLSEELWNWYVEFKNFSFVFKDGWLWPSYNAHLWSIPYEMRGSIVIFTACLALARATHKARLLSLVVLTWYFLYVVDGYYCAMFTTGMLQCELDLLARRLAEGKPGSYFPRWLRALAPYQTSLLYLALAVGLYLGGVPSETNKVENLRTGPNFGWYWLSYLKPQAVFDYKWFYLFLAANMIVLCAGRLRWMRRFFESRFCQFLGRVSFALYLVHGPILATVGDRVYYAVGWYRDQSEHAEPIAHWINRFPLPRIGPLGLELNFLAANLFLLPFTLWVADVVTRAVDEPAVKFAAWLYKFVQNYGGDAGEKQVPLAPLTRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6X4</accession>
    <name>A0ABR3V6X4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000286">
        <property type="protein sequence ID" value="KAL1837514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="531"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="730"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="931" mass="102991" checksum="B370F4AC7A561232" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Y3</accession>
    <name>A0ABR3V6Y3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-mannosidase B</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_3944</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000300">
        <property type="protein sequence ID" value="KAL1837385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="18">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="15">
        <location>
            <begin position="195"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="17">
        <location>
            <begin position="686"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="16">
        <location>
            <begin position="779"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1837385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="851" mass="95852" checksum="A5B512442C4D0132" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V715</accession>
    <name>A0ABR3V715_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000285">
        <property type="protein sequence ID" value="KAL1837531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="186" mass="20935" checksum="386EA0FDDDA1B38F" modified="2025-10-08" version="1">MCLIGLLLPLEPKNEPKKKRRHSHRRSRRSSTPRSPRPREPDKDKPIDSKARAEDALANLCLTLQQSLLEERQQWRDQDRRDIIQEERRRLATGMRYSEAAPPYPVDDNDHSTMPHPPPLEVRSQAGVAESPGCSREHRDAASSSSTECCRKCVCSRCGFEVTKCPAVSEVPGKTPDRGAESPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7G3</accession>
    <name>A0ABR3V7G3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000271">
        <property type="protein sequence ID" value="KAL1837695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="377"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="701" mass="78793" checksum="4F6CE6785F3E1909" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7H0</accession>
    <name>A0ABR3V7H0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000267">
        <property type="protein sequence ID" value="KAL1837734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="85" mass="9288" checksum="027FEE665BDB7DE9" modified="2025-10-08" version="1">MSSPDAESTKSLPDAEPNLSSPYRNKERKLICVIAPPVAGKTTLARRLVQEYKSVHVCVDELLRGMPMRERERASGGGDSTTMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7M1</accession>
    <name>A0ABR3V7M1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000293">
        <property type="protein sequence ID" value="KAL1837446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045634535" evidence="2">
        <location>
            <begin position="16"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="461" mass="50726" checksum="AC53643557541B93" modified="2025-10-08" version="1">MTLLTPSTLLTVTAATLSTSTVPSPTPLAPAPPLPAAIAARAEALITPSPFPSYPTITCLAISTPEHTTTRAWGGLYTSSAGITATCVTLTGPDHILPFTPAAFYSASCQTYTYTNTRFWPAGSDTATNIYCHAVQSNNHPQLCLPVAPLTWTALVLSFFTLHLGWWILDLPLLLRSRDDGGGWHAYVSSIVWACFRCHAPTAAFVLALWYGRDAGEYARVYYLGVWLDAQQEPDGRRPHPTWVPGRSLRWWLCLGGEGVTMVAAGLTIYVTYVLPEYDEKRWPVSLWMIAALPGAVVGVCLLVAEVWFLRRRRENKGMWWVVGGTGTAVVGVGVVVGVVSWWTDADKHESWYLAVVFYGIMALPLAMTNALVQFQMFVPMSLRILGVTIAALRQYTGEQPFCKMNGYELPVVYIFMGFFEMFGAMIPAGQFWGSCFWRKPKLEESEGGVVEMAPQATDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7T8</accession>
    <name>A0ABR3V7T8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000287">
        <property type="protein sequence ID" value="KAL1837506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="166" mass="19126" checksum="B2593B8AF822DD3C" modified="2025-10-08" version="1">MTQNLDKHTIVQDGGRARACLLILLLLCVCLPALLGGYILTRLISCPFVLGLIWAHDNTNYEGNGSESYLVICLSWVEKKKEIKYTGSSFHVSFCFPFPCSMKKTHTPHRWLADRDSDLGWGEYDHCQYCYLFYILWPAFLSPFYPLNVMHVLSLQWSGRVLWLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V812</accession>
    <name>A0ABR3V812_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000250">
        <property type="protein sequence ID" value="KAL1837945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="174"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="577" mass="60386" checksum="88074D096E14776C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V814</accession>
    <name>A0ABR3V814_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_3276</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000254">
        <property type="protein sequence ID" value="KAL1837890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045673892" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1837890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="248" mass="26751" checksum="CFFD482A1CDE0FC9" modified="2025-10-08" version="1">MLLNSFVGSVVLLAGGAAAHGAVTSYIIAGKNYPGYQGFSPMNSPNVIQWQWNDYNPVTSATDPKLRCNGGRSATLAAEAAPGDEITAIWQQWTHSQGPILVWMYKCPGSFSSCDGSGAGWFKIDEAGFHGDGRTVFLDTERPSGWDIAKLVGGNKGWTSKIPQNLAPGNYLVRHELIALHQANAPQWYPECAQVVIKGSGTKEPPASYKAAIPGYCNQNDPNIRVPINDHSIPQTYKVPGPPVWRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V839</accession>
    <name>A0ABR3V839_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000262">
        <property type="protein sequence ID" value="KAL1837805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="338" mass="38435" checksum="57C3AA57645748F9" modified="2025-10-08" version="1">MSRQRSQRAQPSAEFPLVAVAATPRPDKRKRRATGSEGTIGNEGSPSGTQHKRVRFADDVVAWAPSAAPSAAPSAPLPSAVPPAVPSAAAAPPANQATSCLHRKLVRDAVDRYRTARKTRERLEYERKHILPLKSQGMLFEGRVAFLHARHRAEREQQQQQKPITPSGAQERVSYPQIPALCPPMPPLQHPRPVSMVRRRRVQRYMVQWDAMLQSEQLLRERASMLQRAQQSGQVVHIVRDMQQPPRLMQAGQRMGQLVARQRAPDRLAALHRPWVESEQRLRQQMMEEEGLEQFIKRIVGEDGFERLVKDENEMDWLVGLFRGCEIDDGDEDEWMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8G1</accession>
    <name>A0ABR3V8G1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000302">
        <property type="protein sequence ID" value="KAL1837363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
        <property type="entry name" value="CYCLIN, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="76249" checksum="E3852178FCB12194" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8G6</accession>
    <name>A0ABR3V8G6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_3305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000257">
        <property type="protein sequence ID" value="KAL1837857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="201" mass="22168" checksum="6FCF28B7EB1F529E" modified="2025-10-08" version="1">MRLTSALRSDFYNESGFQKITRRLKEEPLVPIGCLLTIAAFTNAYRAMRRGDHHKVQRMFRARVAAQGFTVLAIVAGGMYYAEDRNKQKELWKLKEQQDAEERRQRWIKELEARDEEEKAIREMMDRKRKRVAEKAAGAETGTEGVAAAARAALKEAKAAKGETTGVDSTASQGEPSGSEKSSSSGAAGSLWGLWGGSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8T4</accession>
    <name>A0ABR3V8T4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">leucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_2862</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000227">
        <property type="protein sequence ID" value="KAL1838253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1345"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="1388"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1213"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1297"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1649"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1303"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1314"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1650"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1696"/>
            <end position="1720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1838253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1797" mass="198285" checksum="AE8D83F18E742EA9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V903</accession>
    <name>A0ABR3V903_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000281">
        <property type="protein sequence ID" value="KAL1837573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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</entry>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
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                <person name="Grimwood J."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 620.91</strain>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAB4</accession>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Lipzen A."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1838663.1"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="307"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="627"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="798" mass="88856" checksum="C5A46847B172B7BD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAC1</accession>
    <name>A0ABR3VAC1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_2212</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000193">
        <property type="protein sequence ID" value="KAL1838784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1838784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="140" mass="14545" checksum="11DB0579DEB91C00" modified="2025-10-08" version="1">MAGIPPRPLTSHMRQPSLSANLGGGQSPALLARVNEKKAELENLKELRDLSAAVAAQMEALEQKLATLSDGTEAIAMVLSNWHNVLRAISMASAKLPKPAAAAESADAGVALPETLVRIPTEHAPTLQAHADNAVEEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAC2</accession>
    <name>A0ABR3VAC2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 14">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_2267</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 14"/>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13 14" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="17">
        <location>
            <begin position="671"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="17">
        <location>
            <begin position="825"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="18">
        <location>
            <begin position="1197"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="734"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="13">
        <location>
            <begin position="1201"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="13">
        <location>
            <begin position="1228"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="13">
        <location>
            <begin position="1348"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="1230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1838730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1502" mass="165090" checksum="207E46D060596A05" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAS4</accession>
    <name>A0ABR3VAS4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000192">
        <property type="protein sequence ID" value="KAL1838807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045207410" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="131"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="419" mass="46495" checksum="600241D7163722A6" modified="2025-10-08" version="1">MSIHLSRIQRALGLAALLLSPHAALAHDISDNYAGTPILTPPTLQLADLDVACPLPLDDHPSAWPSLGSPWTHPPVCESSADGTTKYCVYTNSRHGPRGWSIVTTPETAANSVWILNQALNGTTTKTRLPEPPAYKMVDVPGKGKGLVTTRKIRRYEEILVDHATLMVDIMFTTRVPAFLGYRLLHAAVNQLADAESVLALGQSNTLARDKIENILRTNAFNAKLGGAPHIALYPLVSRINHACKANAYTRFMPETLQVSIRAARDIAAGEEITISYIPVGAPTSERAKKLSTWGFSCQCSLCQAPAEEREASDKRLGEIQQLRDYAIRAFQAGRAYQALRFTRQVVNLLAPEELWPLYAEQYENMARIFYTLRDRANAEKYANMALELLAEQGHVPRADKREVERMFAKFEEEEGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAW0</accession>
    <name>A0ABR3VAW0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000182">
        <property type="protein sequence ID" value="KAL1838973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="251" mass="28341" checksum="DD2B5F8EE1A689A5" modified="2025-10-08" version="1">MLRQSISATSRALRSTARLGTQRQSALRLTQSFQTPIAATRPIALRTRWYSSEAGTAKKDGEASASNGDKTNAAEEAKKEGEGESLEALKKQLEQKEAEVRDLKDRFLRSVADFRNLQDRTQREMKAARDFAIQQFAKDLVESVDNFDRALSMVPPEKIKPEQADESNKDLVSLYEGLKMTESILMQTLKKHGLERFDPQGEVFNPNEHEATFMTAMQDQENNTIMHVQQKGFKLNGRILRPAKVGVVKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAW1</accession>
    <name>A0ABR3VAW1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000189">
        <property type="protein sequence ID" value="KAL1838858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <name evidence="7" type="ORF">VTJ49DRAFT_2407</name>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
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                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CBS 620.91</strain>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="1723" mass="188825" checksum="D57EF137D79C26E1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
            <begin position="1139"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1304" mass="145826" checksum="80479C01249BC701" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC01</accession>
    <name>A0ABR3VC01_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000169">
        <property type="protein sequence ID" value="KAL1839224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="630" mass="68520" checksum="3F149ECD74EAC955" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC96</accession>
    <name>A0ABR3VC96_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 130</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000156">
        <property type="protein sequence ID" value="KAL1839459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42537" checksum="635011B83AAFD17A" modified="2025-10-08" version="1">MQGFNMGRYRPPDADEPGGFSRPKRRAITASAPVVRFEMPFAIWCAHCPKPTLIGQGVRFNAEKLRAGAYHSTPIWSFRLRHADCGGEIEMRTDPARADFVIVSGARRRDYGGADAEDEDGSLVASLGAVAPIPTPRERDEQRETAFGRLEKTIADRERLLSASQRIAELQEEGARRWEDPYSQNQRLRKAFRAGRHAREREAARAEDIKARLGGIGIDLLPETEEDARRARLVEFGSVVDTAGGEDGDGKGDADPVRDVRLNKTLAKPLFEPSRSNGGTGDKKGDGKATPRRLKSEIKAARMRENLVAEIISNTRAAKDPFLDFGNGSKKDRPLLAGLKRKRALEEAPDPPRPSSAPPTSIAEEDNGTPSSKGTAGTTPLVDYASDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCC5</accession>
    <name>A0ABR3VCC5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1593</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000160">
        <property type="protein sequence ID" value="KAL1839391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="11">
        <location>
            <begin position="429"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="626"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="829"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="1732"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="777"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2104" mass="235437" checksum="C76FEF0E426EC1F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCG2</accession>
    <name>A0ABR3VCG2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000152">
        <property type="protein sequence ID" value="KAL1839528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046540092" description="Ecp2 effector protein-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="66"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="174" mass="18370" checksum="9B6F68EE2CDDEC40" modified="2025-10-08" version="1">MQFKTLVTILTAAFAAGVTAAPAPAAEPVNAPVPATDEGLYLRALSEAGTSEPLSPLLAARAPKDTCGHSSFNGDTNDNSPTIADCQRLASNLSGEGTWMVYVYHGTKTLATYGTCKFTATTISQTGTYVGDTDVQDLIRDSIRMFGKNGRIGAYGAMNCHPASEAVFWSIRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCP2</accession>
    <name>A0ABR3VCP2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000157">
        <property type="protein sequence ID" value="KAL1839443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="75"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="248" mass="27558" checksum="A204685A1DF02093" modified="2025-10-08" version="1">MAPDTDTENGSAGPGCGEPGPAAADTVEPAPADNPAPSGVSAPEVPSQSERGTAPEEPALPPLTPQEFRIYNRLAEKMDYFHEHFRQMYTTLQTACATNRRPAGMSLKQFLDEGLNLVHYLETHHSIEETYLYPLLARKMPEFRATAPPSGSSGSAGGKGKGPKGKGKKEECELIRQHREIHEGMDQMAEYLRKCKSKECEFEMGVLKEKMEGWGEVLLRHLDDEVRELGAEKMRRYWTVAEMKSIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCS3</accession>
    <name>A0ABR3VCS3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">VTJ49DRAFT_1482</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="EMBL" id="JAZGSY010000155">
        <property type="protein sequence ID" value="KAL1839473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="21" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 21" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 21" id="KW-0408">Iron</keyword>
    <keyword evidence="16 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="24">
        <location>
            <begin position="243"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="23">
        <location>
            <begin position="538"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="25">
        <location>
            <begin position="1007"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAL1839473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1106" mass="124671" checksum="DDE91C8F318E90A7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCW5</accession>
    <name>A0ABR3VCW5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000168">
        <property type="protein sequence ID" value="KAL1839231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046499468" evidence="1">
        <location>
            <begin position="20"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="293" mass="32554" checksum="B5E26A555D12F849" modified="2025-10-08" version="1">MKLSSLLGALALSSASAWAEGIRGLFLYKDVTKSDTNAIRTSGYNTVLLFRFVPQSSGDILYTASNTPGSGDVMVATNGAYSGGDALAAKVRSLKDGGAIKRVEIAFDATRLEGLTANTNGASYLRFKANLAALKNAWNVDAVHYWEDYDGAYRPVLRFANIARDVGLKISGMGFQIERVSTIWEDLQEDVNKGRPADNLLFDRIYVKCFNDSATVYPTSFAHRLKMDTVPVLWTNHNGKMYNTSPDQARKKFTDWKKDQQYIRGGAFWRDSDIETYGPSYQAYGQVLREVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD30</accession>
    <name>A0ABR3VD30_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S5 DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="307"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="471" mass="52984" checksum="3447CF59B62E3D32" modified="2025-10-08" version="1">MPGCEAKTSDGDNDDDNTWHDNNSTLSNSGSSLHRLSARRRPRFANVRASDMGLMDEKQIEEFTKEKFPKYRPEELAHLGKIYSPEQMAALEAGEAAIDPRDLTVQGRLRADPYRMPYIDDFAETQPVIDKRARNKAPPDPHARFMNLDEFAQDLIDWSDKLPQGEVTGSLKRLEDFVPEAYRARPETQWPTEVREDARKKFQRYMEGEVTKQQKALNAKGSDALSDIGSGPTDADILQYILERSVMTDANRQTDSSLAPALPNKVPGVAGLYKTVIDPEDQGKDDLGVYQDVKRRTGMTVREILNLRDKQLLVRDVSNQTRLGKVRSCSVIHVVGNGDGWLGYGEAKATETQLAFRKARINALLNLRPIRRYENRTIYGSITAKVSATIVKMEARPPGFGLRVPYRIFEMCRAAGIHDLSASMPRARNPMNSIKAAYWALCNQPDPEEMAMARGKKLVDARKVYYGGAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD79</accession>
    <name>A0ABR3VD79_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucan 1, 4-alpha-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000141">
        <property type="protein sequence ID" value="KAL1839757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="67538" checksum="8DB7F3F2BC13259A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDD8</accession>
    <name>A0ABR3VDD8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF89">
        <property type="entry name" value="ALPHA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="192"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="507"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="846" mass="96747" checksum="0DB85148D79718AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDW6</accession>
    <name>A0ABR3VDW6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="130" mass="14415" checksum="E6D4F54DC0D2BD56" modified="2025-10-08" version="1">MEAPSCSDNEYHGHEDPVNFELDDVIAEYGRLIYHQGDEAWVSAALAAANNNDILNYHEQYDASRGLQAQARDLVEGLINSGVSWGRLWAEACRKWAGTEDAEEKGWYDALMEEMVIRVRGAALAGLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE15</accession>
    <name>A0ABR3VE15_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylulose kinase</fullName>
            <ecNumber evidence="7">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000134">
        <property type="protein sequence ID" value="KAL1839938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="9">
        <location>
            <begin position="301"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="580" mass="63241" checksum="8F2BC6545AC35488" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEI9</accession>
    <name>A0ABR3VEI9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">VTJ49DRAFT_770</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="13"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="557"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="491"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="768"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAL1840154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="794" mass="86053" checksum="8149569695BA4D8D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEW9</accession>
    <name>A0ABR3VEW9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000129">
        <property type="protein sequence ID" value="KAL1840062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="136" mass="15679" checksum="51BB8E07AB64FAA9" modified="2025-10-08" version="1">MSTITRTLGNLRKIGLKEYWHQLQYIGDTKAGVLVGVDKFGNKFYENKDELPLRTRWVDYAKHDYDAGHIEPLWHAWISYAVDTPPNQDPLMATADARPWAPKGHIPNRTFTRGAYKPYNTTKPKIESWQPVAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEX8</accession>
    <name>A0ABR3VEX8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000145">
        <property type="protein sequence ID" value="KAL1839686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="267" mass="28371" checksum="3F7264890DDEEB0F" modified="2025-10-08" version="1">MSVATPFQTLFAVPMTCDGCAKDITDALHKLPGIIKVEASVKDQLVSIEGTAAPSAIVEAIQATGRDAILRGSGSSNISILETYHHDHRQEAEVTPADADANSGSWVNQRLVRGLARMVQVSPTETVVDLTVRGVPPGTYRATIREYGNLKDGASSTGPVWSAPEGNKMENGGSGPRGYLGTVEVGPNGYGSAFLNKPFQVWEVIGRALVVSRMDEGEGKPLSNEEDTVVGVIARSAGVWDNDKTVCSCTGKTLWEERKDEVAKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF18</accession>
    <name>A0ABR3VF18_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="61722" checksum="5ACC0B0076C9135F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF82</accession>
    <name>A0ABR3VF82_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27764" checksum="58D9F61581F54594" modified="2025-10-08" version="1">MPTLRPRKPRSGQSPSPSETAAEPPTSVSSAVPPSATRQRKTQRTATEEKHQEESQMAPPDEENPLLTDHASPPPPRSSLPPESLSWTQRNQWILFALASGACAAFNGVFAKLTTTELTTSLSLGVSRLLGLENAENVVEWVVRGSFFGLNLTFNGVMWTLFTTALARGHSTTQVSIMNTSANFVLTALLGSAIFSEALPPLWWLGAAMLVAGNVIIGRKDEGQSSHDPEGEQGGEVSAPFGIREENRESTDGQSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG48</accession>
    <name>A0ABR3VG48_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="458" mass="47835" checksum="418243B3EF484883" modified="2025-10-08" version="1">MASDTQRLQHTGQSSAAMDSSPQRSGAPSPQRRYDESWVEVSSQPSSSSLSSIGDDIVTPGFRVSNNSYPPRRRRTQQQQPMPATFIIGHPASQGGATSSQEEYDETESEEDRVLTSSTEAIPPSTTSLFRQQTAMRAPAVVDSDSDDDDDENATALGRPSNTPVFRPQPNAFSHPPSYLSHRHSTGSAPLPYQHPSHSRPSFHSRGHTRSHRGPPDYLSPAYQADNDAALRASLTTLLSCAAAARGLPKHEERCTSAPGVGAGVVPSNQPMELRLVPESELMTDDAPAQQPSAASPRGGGGLNKPPTRTASNSSAPSAPPSSASSRDDRNAEKTKRAAAPQSRPARAAKKKRTSTTAADADAVATAAPFLSSVVSPTLLPWVVSAGLVVLVSVVGFGAGYVIGREVGRQEGAASSVFGLADSASNASSAATTAAGCGGEVVSGWFGSGLVDDAWHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGE6</accession>
    <name>A0ABR3VGE6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000093">
        <property type="protein sequence ID" value="KAL1840938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60604" checksum="A49172CB8CD62A49" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGI1</accession>
    <name>A0ABR3VGI1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_519</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000115">
        <property type="protein sequence ID" value="KAL1840393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="62"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="294"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="568"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1840393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="76494" checksum="C1F7929A0630E011" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGM8</accession>
    <name>A0ABR3VGM8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="505"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="794" mass="88384" checksum="8267EDE288E08D5F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH17</accession>
    <name>A0ABR3VH17_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="135" mass="15765" checksum="C92E47D7044FF1A8" modified="2025-10-08" version="1">MKFLKTSRVCLVTRGRYAGKKVVIIQPVDNGSKTHPYGHALVAGIERYPSKITRRMSKSRQEKRSKVKPFIKVINYNHLMPTRYTLELEGLKSVISADTFKEVSQREEAKKTVKKVLEERYTSGKNRWFFTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH51</accession>
    <name>A0ABR3VH51_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052370">
        <property type="entry name" value="Meta-cleavage_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139:SF65">
        <property type="entry name" value="HYDROLASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139">
        <property type="entry name" value="SI:DKEY-122A22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="125"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="475" mass="51490" checksum="65436061C2558AD0" modified="2025-10-08" version="1">MSFWALRLQPPGPAGPSTTTMTPLWCLALGAATLGVSAALILSTIHDDDNTTYSAKTGKKKKKIATKKQTSIPSPLTTHLPHLTLSERSALPYPPDLLPGARSVPTPYGTIHVFEFGPLDGPKVLLLPGISTPCISLAALAESLVARGCRVMLFDLFGRGYSDAPLPGEVDYDLRLYATQVLLVLASSPVAWTGDDAFHLVGYSLGGGLAVGFARYFASMVRSVVVIAGGGLVRREHVGWRSRVLYGKGWLPDGVVHWLVRRRLMPPEGNGSGGRTETKMAAEAVGNGNGAEKGRWHKNSDVRGGDDFDNAVLLARRPEYTVSSVMDWQLRHHEGFIPAFVSSIRHAPIYEQTEDWLALGQHLNERRTRPELPGLRGGKILMILGASDPVVLKEEFIHDATAVLGEDGFEAVVFDTGHELVMTRADDIARAVSAFWKRTQGEARLPPADPPRQPCQAAKNPIGRPNQRNFSPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH89</accession>
    <name>A0ABR3VH89_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_7464</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="54"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1841033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="260" mass="27886" checksum="15A82E729754EFE1" modified="2025-10-08" version="1">MSSSSPPPEEAPTTTTSHEPINAAEEDPSPPTESAPLLGRPGDATQKPTSPLSRNLLLGTAWLAQLGALLLLTTLLYAIVTHPTLPLVTPHPLLQISGIIALLQAILILQPTFTPETKAAGQRVHAALQGLTMLLLAGGVAVIETNKKINKMPHFHSAHAYLGAVTLGLLVVQWVFGVTIWAVPGVWGGLERAKGLWKYHRWVGYAVLISLLATVTAAAETDYIKKVLEVKLWPVLLAEVLIVAGVFPRIHPRKLGIQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHI3</accession>
    <name>A0ABR3VHI3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dihydroxyacetone kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_7124</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="13">
        <location>
            <begin position="9"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="12">
        <location>
            <begin position="393"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="560"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1841344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="63557" checksum="3C825C5C5560E79D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHL0</accession>
    <name>A0ABR3VHL0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="423" mass="47176" checksum="AAF1F1A8DED15D36" modified="2025-10-08" version="1">MVTDNIPHGPRDVVRLKYAGGTVGVTIPRSIMQERAPKLYAAVDADGYIDLSLYSYQVIRDLQYYITMQVYEPADPANARTDPTAAAALFKARLDISLIARTAELPALSDLVIKHLEEDVKFFGPVLAIDAAKAAYPRSLEADPTYAASLQSLESVELASVDRGMPKSEPIPQVAFEERMRSAVPEGGGKYEALFEPFARELRDGTSPSDVVQLRFAGGVFFDLPRIEVQMKCPKLYVDDRGDVNLGLYSGTVGEDFVRYIKTGQYGPGNPANARDSEMVHSLFKSRLETCLLARALELSRLMALATKDLEELVKFFGPLWAATALEAALPLRSRETQPIGLGFVRYLENTKLGELDSSMPKSKLIEQTPFVWRMLRHVPPDELSRYEAMFEPFATTMKDGYVDSMLEYFFGWMRDGLGPRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHT3</accession>
    <name>A0ABR3VHT3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29102" checksum="8A7EF813C575FA59" modified="2025-10-08" version="1">MAPPPLPLAPPAPAPHLAARDLARRDLTVNDAQRVTLGIIAAYIVGIALLWNLPYIKWVLWPFKMLVIAFHEFGHAFACILTGGKVTSIELDPREGGVTKMLGGRQIITLPAGYLGSSLIGALLTFAGFNINASKIASLVIGVCFLLTLWWGRRDWLTILTILAAVGLLVGCWFIAHAEALRFVVLFIGVMSSLYSVWDICDDLILRKVNSSDASVFAKRYGGSSQCWGVIWSIFSLGFMAAFIVAAIAAFPQSAAQQREDAQKFLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHT5</accession>
    <name>A0ABR3VHT5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="466"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="636" mass="69821" checksum="26127D3C077F34E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIK6</accession>
    <name>A0ABR3VIK6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="197"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="672" mass="73200" checksum="535991E76CB4F451" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIT9</accession>
    <name>A0ABR3VIT9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inner kinetochore subunit AME1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="2">
        <location>
            <begin position="581"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="780" mass="84427" checksum="96B1BFFA604DE89C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIY3</accession>
    <name>A0ABR3VIY3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3 8"/>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF41">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047404544" description="Mannan endo-1,6-alpha-mannosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="472" mass="51132" checksum="F0C7957E5D643607" modified="2025-10-08" version="1">MRLPWVAATLGVLARSAAAIELDLNSEDSIKDAASTIAFGLVRYYTGNYTGDTPGNLPDPYFWWEAGAMFGALVDYWALTGDDSYNAITQQALTHQGTEKGDFMPTNQTRTLGNDDQGFWGMAAMSAAENNFPNPPPDQPQWLALAQSLFNQWASRWEEETCGGGLRWQIFTFNNGFNYKNSISNGCFFNIAARLARYTGNQTYADWATRIWNWEESIGLITPEYAVRDGIGIEPLTGECNGTKTMDFNQWTYNAGIFLHGAAVMYNLTNGSAEWRARVDGLLNTTTATFFTPHEDPSVGNIVMFEQLCEPSGFCNIDQRSFKGYLTRWLAGTATVAPHTVPLIRPLLEADARAAARACSGSVPEPEFKGHPGTACGFRWTTSAGFDGMVGVGEQMNALSAVMYTLAAKPGAPEPLTADTGGTSKGNYAAQGRTMETGIGYADITVRDRVAAGFLTSAIGLGVVAGCAFVMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIZ3</accession>
    <name>A0ABR3VIZ3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="398" mass="42448" checksum="7FBFC13E6CECD3D5" modified="2025-10-08" version="1">MSHMWTPEPMADAQYARRRPPPMEPASNATYTHSRTRTTSSNVFPFPMQPAYFPNPNPAPPNPHPYQQHHQPSPIHLTQPPAAHPQRRSPSVNTFSTVSSGGMPPPAAYRTSPTLDIRRSTSSRSGGVPGSHVGGYVAFLRKQKATVWCDRAQHEDPRLLAQQRAAKQRANMELMGAVTGLGIGSVSSGRTATGLSTSGKVAAKIRHHGKPTVIGYSPGSAFNGVGGVPLRLSATEVEGEESDDDDPILRQHYGQHHRRTGSSGRNSIASGGRRTMTGTYRTSGSGHGAPASRWSPGDTPERRGSLADGQAVAPAPTADNDAGSVKARSVASGDSTSAERLDTLPELGSGHLAANSMKHATVTREKSVKSVEELRRRGSVDERTMTLTTGRLYIANPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ00</accession>
    <name>A0ABR3VJ00_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein rsm22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="39394" checksum="690C0505918E3504" modified="2025-10-08" version="1">MAVEIWPHVAPDQLKAATDAAEKRELDWLIEELHEYLTNLKHGLEDCYALLAPIEHGSTLVLSTPRNEVVKGTITRVGTRIVRGTIHIRMRTLPHQTLTINPDHPIHLAPLTTLHSLLTHSIDLLNLTLTYAYPSSSSTPPTSSTQRTPHLPTDLPPPQFLSAQLRLLSQSLAEASAQLRGASSTSGSATDSSWTTRSAAPSHFNPPLTQPHPGSTHPALSFHLTVQDAQLVLWLRSLEPVDAKVNFGTKLALAIGTTRRLEHDESERIFGYCCNHDTSGGGGGGVVTGPRGSIASGAGPVHIPLSGTRTRSVDVYVREKVRVETADPSLMSLSAKLTALANTLALARRNLAAVLGEEWEEDGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ43</accession>
    <name>A0ABR3VJ43_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="153"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="594" mass="66153" checksum="FAEF1BC30DDD2449" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ50</accession>
    <name>A0ABR3VJ50_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endosomal spry domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000059">
        <property type="protein sequence ID" value="KAL1841920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53493" checksum="1FD5D6D16A420EA6" modified="2025-10-08" version="1">MAPAIINTILGRSSDSAPLGPIEVGSVLLARDELPPAHDPTEGIIRPQDINNNAVFAMFGLLGAAFVIVGIWFFFWAKNGGFYFKKTDWDDYTSTVLRRKVGPNGTIYSDATPSTILGGGSVYKDVDDRTTTVGDDNTTVVSGTTGITGITGGVSDISGRERRRKKREQKEREKERRREEKMREKEEKRARKSRRKVGEDGMVIDEEAAAEAEEQLRSYRHEKPARVGGINREADGSEWDGSTNPTWSTMSPSSRAAPSEVTTTTEGTGSTVTDDLLSNRQRTPTTTPTKTKDAARIRKVYSTAEKTARREDERLRAEARRLQEKGRAAVAASSRNNTSTSSDNAVAIRRDFSFVRGSEDRMALRRIDELPATAESVISESTALSATTASTADNDRNREREARRQHTRSRSRHERSSSRVIESEVGGSSVVSGSSAEDEVGTKVYTHPHHIPTGVESSIAPESSISNYADERRRRRRSHRTSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ76</accession>
    <name>A0ABR3VJ76_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="387" mass="44071" checksum="9271381278468CB1" modified="2025-10-08" version="1">MPVYYSPPPTPTSSLPPSRSRSFSTTPSTTTTNNKSSSSSSRYDHSLSRSTSNRSTCSKHNHGAETKREIPYLFLGSIAAASLVVHKYWPKGFPYGEKEDWELSPLALRAKERRLREKAERAERRLKEKAEGVGHRVGILGRRGSKSSGGCRLDEGLDGRAQGSKYGYYGHLDRQRRDECDECFTRDDRDFWTWDKSGSRRRRERRGSVTGSSSAALLGRPREHGLDRDSHHSSFSSYYDGRRGPYIDEPPLLLPYCSTSSYRRVASRERTNPFLADTDLYPLDYSRPPRRYLLTDNNAATTTAPPSARYFMDRRSSLDTSRLATRSSSSRRGYYIDDYSTLEQPPETVVYLDGDPPAVTTTRARRASFDAGRVGRYYDDGYDWTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ82</accession>
    <name>A0ABR3VJ82_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="446" mass="50859" checksum="6AB43E86BEBEBE51" modified="2025-10-08" version="1">MEQKIRVHSFQEAKTYAALGQKVVENFSSQLGIGGDLETIESINADHRDMTKFSDKEDEGYRAVRGVLQTCIRTLPAQSRPSVAAPTEVDIVNSRMTEPEPILDENEQRQVQRFSSDYVTPLQDIPERHPGTCEWILRNKDFNSWIDGPSTALWISGPPGMGKTVIAKFLLEHFEKSTPSRKTVHFFFSDRDGTRRSPIAFLKAAIHQFIRHSARLFKEHVKPRIASFGDTVYESPALLWDIFFDMTQDPTLGPLVCVLDALDECDPKSWQDLIRRIGAHFSPSAESQGTKSSQQFKFVITSRPYDDINIHFSHFSVLRLQAENEDRRINQDITLFVENEVSRLAERRKYSPGLKTMVQGALIAGADGMFLWVHLMLEILSKTPVTRVSEQLRTLPQGIDPLYNRILDEIPKESMDTVKVILKWVVFAVRPLTLDELSMAVETFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJL7</accession>
    <name>A0ABR3VJL7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="891"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1679"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2259"/>
            <end position="2583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2401"/>
            <end position="2426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2547"/>
            <end position="2596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2405"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2567"/>
            <end position="2583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2584"/>
            <end position="2596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2596" mass="290212" checksum="9AE0793603D3667C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJQ0</accession>
    <name>A0ABR3VJQ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000053">
        <property type="protein sequence ID" value="KAL1842124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="147" mass="16733" checksum="388C606048576CCE" modified="2025-10-08" version="1">MSTQKKDAKDSKAAQRQAPTLEEMDTLKLKKAWEVALGPIKNLPMTAIMMYMSGNSLQIFSIMMVFMAFKNPIMGILATNQAFERFETETNRARMLQVKVAYVIMQLVALGLGIWKVNKMGLLPTTRSDWLAWEERREPLEHAVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJW1</accession>
    <name>A0ABR3VJW1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="321"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="551" mass="62823" checksum="B8F187300191B2FC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJY5</accession>
    <name>A0ABR3VJY5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clock-controlled pheromone ccg-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046067390" description="Clock-controlled pheromone ccg-4" evidence="1">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38747" checksum="BB76810C235A13AA" modified="2025-10-08" version="1">MKFTLPIALLAVTASAAVVDQDKRYCEAEGQSCHTVKRAAEAFSEAIRENAGLVTREETSSELSYIARRQLHELALAVAASHENPRSFYDSIATPATADKATEKRDAEPGWCTQFLGMPCWKRTEKDLPTKVRRDPAPGWCTQFLGMPCWKREEPATPVRRDPEPGWCTQFLGMPCWKREQSPAAGNEVAKREPEGCTQANGVPCWHKRDEVTHVPRDVATPVRRDPAPGWCTQFLGMPCWKRDAQVEAREPDRHCSRFTGGSCWKRDGSETALEEVKRCTSEGQACWKAKRAAVAVVNAIDAGNAIKMKRNPDWKREASCSAPDGLCTKATRDLHAMYNAARSILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKM5</accession>
    <name>A0ABR3VKM5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="350" mass="36761" checksum="4ADBE74D1464D21A" modified="2025-10-08" version="1">MAMGPTRLRCEGKFGGGLVGAGLGHVVRESGDQGDKRFREDARLASLAGLAALDGGHLDGLEHVSNTATQGRVLGPQLLVLGAIVFGLAALLVYHKIVCALQALGVPLRKRDVQIELCSLVDAAVEYLKELAACRKPGGEFYFLEDFLAEFHHRHRLGQQLDMAAFMSLMRAMYVARLMWHTERRNPDLRDPNPAHICPLALAVDELENMLGEVEGEWRQAMATAELDSDDGSDEEDGDGGEKRNTNLFQAPASAESAADADMATITADTKNPAFVALAQGVKNMGLGFGGEAMGTGSGNGMDAAGGPAPDADDLAQGVKNMNLGPGGAAMGTAKADNGMDAAGEAMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKT5</accession>
    <name>A0ABR3VKT5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="589" mass="65034" checksum="B67C881524770917" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLM1</accession>
    <name>A0ABR3VLM1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1198"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="889"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1109"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="932"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="967"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1109"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1409" mass="159543" checksum="CD18E41684F62778" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM12</accession>
    <name>A0ABR3VM12_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="160"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="338" mass="37389" checksum="8344B725EAFD166F" modified="2025-10-08" version="1">MQTLNGRRVHQSEIRVNWAYQSNNANKEDTSNHFHIFVGDLSNEVNDEVLLQAFSAFGSVSEARVMWDMKTGRSRGYGFVAFRERADAEKALSSMDGEWLGSRAIRCNWANQKGQPSIHQQQAMQQMGMTPTTPYGHHHFPTHGVHSYDMVVNQTPAWQTTCYVGNLTPYTTQNDIVPLFQNFGYVVESRFQADRGFAFVKMDTHENAAMAICQLNGYNVNGRPLKCSWGKDKTPNHHPHQQHFDPNQQYSPQSAQTPGYPGTPSTYFNQFGGSYGPGQQPGYGGPQAQSPAGYGAQPMGYSGPPSAGGYGRGQQSNAQWNTPPPAGNFNNGFSGYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMA9</accession>
    <name>A0ABR3VMA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED16</name>
        <name evidence="13" type="ORF">VTJ49DRAFT_3337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="11">
        <location>
            <begin position="196"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="12">
        <location>
            <begin position="873"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="929"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1843023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1055" mass="115381" checksum="B326AFC510A3E74F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMT0</accession>
    <name>A0ABR3VMT0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_2728</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="16">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="17">
        <location>
            <begin position="286"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="168"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="329"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1843177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="463" mass="53552" checksum="F3C8696F4B928480" modified="2025-10-08" version="1">MAFKSRMSILPTAQQQSRSRKREEEAAYAIIRLPDRELVGCINELGIPFTLADLQKPNPIQVQMIFEKVGELLMNKTRQTVDPAMRVAAEDLCGDFGDALMPPDTRNLMGFFVSLRQIMLDCGINDFSFADLYRPTHDRFVKVLSYVINFVRFRTNQTGVIDEHFNHAESTKARIEQLYAENQNMEAQLDEMRANRQQMEALVAEKTRRNEELKRKLLELLRTQKEVATRLEEAKTRKGELAAELEDKTAHKLSLKQECAKLKPYTQQSPAALQTELADLTNVHNTTKANIESLDRRARALQTSSDSFAVVCADVASCIKLLEEIAVELAKEEEDNARNAKQRDALTERGANVREVERTEALLQRQLAKWTERTEALRAQSEEKARRAKEKMEELREVHRKLTEERAEKGKDIERRRVRIEQIEKKMLDLKENIENEIHAAHDEYLKMESHIKLYITEMEQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN33</accession>
    <name>A0ABR3VN33_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="627"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="700"/>
            <end position="879"/>
        </location>
    </feature>
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            <end position="292"/>
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    </feature>
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        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
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            <begin position="512"/>
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    </feature>
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        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
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            <begin position="551"/>
            <end position="565"/>
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        <location>
            <begin position="666"/>
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    </feature>
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            <begin position="759"/>
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        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="879" mass="96542" checksum="7DC956CD859BFF1F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNK3</accession>
    <name>A0ABR3VNK3_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">DUF7779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="489"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="708" mass="79414" checksum="728D5D1FCD072A7D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_2741</name>
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        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="1"/>
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        </location>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1843190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="167" mass="18621" checksum="E5A851B686DCF053" modified="2025-10-08" version="1">MARFNSTRNSPLGSKRRPPYPRSTHGLTPPHRGAQRSHERPHLDRRGELEQGEYNSARLEQRRGRMTRRKERPAVDVSAKRPGNPTPETGSSRPRHNLEVDGGGFTPRPKGAYRLFLVACSLRLPGATEAEVSRATTGFPTKPRPIASRKGETLSCDRIVPQDVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_1113</name>
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    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="442" mass="48974" checksum="DDAA6E55F9C13F32" modified="2025-10-08" version="1">MGLPLRDPASFSSFNSGPSYLGRHCTAQDADPALGAADRSDDRNRKLSRHRYREDSKHKHRDCAPGSCRLGRGYQCYRVLASRKPRTHTSRARQVHHRLEARLAPLAAETHHVKPYSPWAADADEGVAVARSSLRLPGETVNGTDNESHASQSDSFSQHDRRRARSRSSTSSSGSQTRPPSLERQDAFRDEKTAKRRRTAGADRAYYFDDSANSYGHFAGDDTAESDADSAETAELYRLGLLYDNDYERGAGFSLAYLDHGVPAYSLRVRQARRPRRRQQWQERQATGWSSQDGVHGGSGSDNHDETMTDRDDGQEYLVDLAFSAFGEHEAFRQWMVPDALGSGFGFSGQASQSGSRAGTRRAPLLTVVYELAEEPEPSPTTDRFFEEDVSVSDLSTCGWAEEDEMAWAVLDAVGEVKGAEKGTLVDGDEVEPWVMLSRDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPY5</accession>
    <name>A0ABR3VPY5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="303" mass="35027" checksum="B91792B1653A78BB" modified="2025-10-08" version="1">MPLRKPTCAVLCSCPSALLSGLGPATLIPATCWPRHARMPAVSSPRPPRRFYASVSDVNPNQKAKRGGNDEPPKWPTSPHPTPYEILGIPKGEPYNKKHFFQLAMRYHPDRQHLTTDDGIPHLTKLERYRLVVAANELLSNPQKKRMYDLYGFGWDQHTDTHTRHREADRTWRQQPGNASMNATWEDWERWHQERDGGKGEKQEEIFASNITFMAAIAFFLIIGTWSQMTRAGTNSMNILDMRDQKHAAICKELQERRNQRVGLDRRDRVDQFLRQREYEKWAYDPPNHGLPLPPPDQSKATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ35</accession>
    <name>A0ABR3VQ35_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="101450" checksum="C34B240B7B9761DF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ45</accession>
    <name>A0ABR3VQ45_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="231" mass="25442" checksum="16FBA7678DE9E6C9" modified="2025-10-08" version="1">MHPQHECDNRGTYEPYLGAHTGCEVTKKDGLILRLRRDGRLKKTISFTINGQKYGLSAYFRLDDALNNRLLRPRHSPSWISLTPSIDFWAATPGVNAAWVIKIVHDSGVATSGNAAGWTQVFEVPNPNAANASDASGSSSPDSENESGRGSIQSRDGGNPESNQHNEGSSATEQGCLAPTLALAQPKMTPGTPWYLQLVFFRQEAELARNFRQVAPLAQFHWEEDDAELWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQU5</accession>
    <name>A0ABR3VQU5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="406"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="711"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="777" mass="82116" checksum="AF4EB9D40EF38839" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR80</accession>
    <name>A0ABR3VR80_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4981</name>
        <name evidence="10" type="ORF">VTJ49DRAFT_7538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000090">
        <property type="protein sequence ID" value="KAL1841022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="213" mass="21615" checksum="1CFCE1A48C454B82" modified="2025-10-08" version="1">MSFRGAPRGRGGFGGRGGGRGGFQQRDMGPPAAVVEMGKFIHACEGEMVVQSTNPKVPHFNAPIYLENKTTIGKVDEVLGPINQVYFTVKPTEGIVATSFKEGDKFYIAAEKLLPLERFLPKPKPPPGTTNKVKKPAGRGGAGGRGGRGGPGGRGGRGGGRGGFGGGFGGGSRGGSGFGGRGGGAPRGRGGFSRGGAGRGGRGRPRGREHTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRY2</accession>
    <name>A0ABR3VRY2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_85</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17722">
        <property type="entry name" value="BRCT_DNA_ligase_IV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="444"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="744"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="899"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1844406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1013" mass="114916" checksum="BD13CBBEB9C94D01" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V242</accession>
    <name>A0ABR3V242_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000569">
        <property type="protein sequence ID" value="KAL1835675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="509" mass="55898" checksum="DA43D72D95E165FB" modified="2025-10-08" version="1">MADEKNGPATEAPAPATEVPETQSAPAGPVQRPSGWMYKGIHIGKKEVWYASPIVQLVMVALVCFLCPGMYNALSGLGGGGQVDATAQNDASTALYSTFAVVGFFSGTLANMLGVRITLAFGGLGYCIYAASFLSYNHNQNHGFVVFAGAFLGVCAGLLWTAQGTIMMSYPPEDRKGRYISYFWIIFNLGAVIGSLVPLAQNINATEATNVTDGTYIGFIVLMLAGAILALALCNADKIRRDDGSKVVLMKNPSWKTEFKGLFETITSAPWVILLFPMFFASNVFYTYQMNDFNGAHFNTRTKTLNNLMYWISQIIGAVAFGYALDFPGVRRSLRAKVSFVVLFVLTFAIWGGGWAWQKQQVTREVVENEEIEYRRYDWTDGGEKYIAPLFLYMFYGFYDAAWQTCIYWYMGALSNSGRKAANLTGFYKGIQSAGAAVFWRLDGLKTPFNTMFGATWGLVAGALIIAAPVIFLRIKDTVSLEEDLKFSDETAEDVAPARDVTVIKQGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V278</accession>
    <name>A0ABR3V278_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000519">
        <property type="protein sequence ID" value="KAL1835872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF3">
        <property type="entry name" value="PURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="64002" checksum="0A8EC7A07C7DA070" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2Q2</accession>
    <name>A0ABR3V2Q2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000567">
        <property type="protein sequence ID" value="KAL1835681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="61" mass="7148" checksum="004E863764CE55F6" modified="2025-10-08" version="1">MDNVNCYTKVTYGVSVLDQVDRAISYYQKDLSSEDRHALLGEEEFRYMSEIARPSEPQENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2W7</accession>
    <name>A0ABR3V2W7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000462">
        <property type="protein sequence ID" value="KAL1836119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="549" mass="61528" checksum="C9AE2266F3AF9EBB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3D8</accession>
    <name>A0ABR3V3D8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000436">
        <property type="protein sequence ID" value="KAL1836280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="86542" checksum="6D549387BB09A859" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3F6</accession>
    <name>A0ABR3V3F6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000459">
        <property type="protein sequence ID" value="KAL1836140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="102" mass="11070" checksum="BF283521B04CB2B0" modified="2025-10-08" version="1">MAPPCPSFLSHHLPAAAQVGPDGKARKTEGGRPIDLARDCELFGFAQYVCVVSRPELPDSPVQCWPVQRWFRRCRDKKGTFMAETTAWEGTASAGGSTTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3N9</accession>
    <name>A0ABR3V3N9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_5232</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000420">
        <property type="protein sequence ID" value="KAL1836377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="12">
        <location>
            <begin position="99"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1836377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="288" mass="32366" checksum="401C1C8816D9E6DA" modified="2025-10-08" version="1">MPWGDPSPSSPSDRGRNDGEYPKRSRVSPSSSTTSRTSDPESWSSRVLHGIRDHFSVPYNWIAPVVAAALAVGAVTFYQTYLRRFPGPAHIDPGFFRRRTLLGKVTSVGDGDGFHMFHTPGGRLAGWGWLRRIPTDKKELKGRTISVRIAGVDAPECSHFGRPAQPYANEALSFLESYLLHRRVRARIWRRDQYERVVATVYVRRPPFFQRQDVGLELLRGGFAVAYEGKIGAEFGGPEMEALYREVEAEARKKRRGLWGVRTAGKESPMAYKRRMKALEESGTGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3P5</accession>
    <name>A0ABR3V3P5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000471">
        <property type="protein sequence ID" value="KAL1836066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="430" mass="44671" checksum="45D31C5CB0F7F6B7" modified="2025-10-08" version="1">MASRHWEQNKDATVYVGNIDERFTQELLSELMTQVGPVRQVHMPQDRVSQTHQGYGFVEFDTPASAEYASKVLNGIRIWGKPIRVNKASADKQKTVDIGAELFINNLDPQVDEKILYDTFSQFGTILRQPNVVRDDKNISKGYGFVSFDSFEASDAAIATMNGQYLLSKAITVEYAYKKDGKGERHGDEAERKLAAEGKKHNILPEKQALPPAFHMTAPIGNAAAAALPPTGPAAVTAPVVPAAAPVPPVPVAPLAAAGMPPVAPPYGGAMPPGPVPGGPMGRGGPPMPPAYGSGSRPPVAPNAGLPPAPSGLPARPPPSHGGFGGPVGGYPQHPPAGFPGPQPPMYPGVPPPPAGFGGPVPPPGAPMVPPPGFVPPGFGAPPPPPGFGRRIALSLARDAAINSLVDEGLPLVIRDHDQITPSSGLSARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3U6</accession>
    <name>A0ABR3V3U6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000408">
        <property type="protein sequence ID" value="KAL1836459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="103"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="508" mass="55623" checksum="11C50CC6A57477A4" modified="2025-10-08" version="1">MTKVFTAEEVAKHTSADSCWVVLHGHVYDVTNFLPHHPGGSKIILQLSGRDATAEFDPIHPPGTLEEHLKPEAKLGVVDPESLKKLHAPRGKPIQEEHRPPPPPLDTLLNMDDIEAAAKTQISKKCWAYYYSAADDLYSKSLNNLAYRQILLRPRVFVDVTRHFSTSTTILGGRYRLPTPLYVSPAAMARLAHPDGEAGIQRGISRFGALQIVSHNASMTPEQIAAAAPEGQILGWQIYVQTDRAKSERMLQRINAMKDKYRFIVLTLDAPVPSKREHDERAGIEARLAFESAASSPASQSQSGKPDPNAGVGKQLFFGTAADLTWTTTLPWLSQHTDLPIVLKGVQTHEDAFLAARYSRAHPEWNLAGVILSNHGGRSLDTAPPAVHTLLEIRKYCPEVFETIDVWVDGGVRRGTDVVKALCLGAKAVGVGRAALWGLGAGGERGVGRVFEILQGEIETCMKMLGARSLSELGPRFINTRAVERDIFDGDSGLDRSGLWEPPSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3V9</accession>
    <name>A0ABR3V3V9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000409">
        <property type="protein sequence ID" value="KAL1836452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="421" mass="47966" checksum="E48791EC5D4A40FE" modified="2025-10-08" version="1">MRLINVKTRKIHDFTTDAHTEPYAILSHTWGDEEVSFEDFQTLSPEALSSKKGYTKIDYCCKQAEKDGYICCIDKRSNTELSEAINSMFRWYQQAAVCYAYLIDVDPYEIPEGRGLELLAPREIIFYVSGWTVIGSRTELFWPLVKITRIPSNYLCGEDRLASASVGMRMSWASKRRTTRVEDMAYCLLSIFDVNMPLLYGEGKRAFRRLQEEILKSNPMDHTLFCIVETGPWNEDYAEYGLRGLFADSPRDFRCVNAMVPWRSTEAFYNSVQLAPSTAAPYPTLSGPSVVLALHVASSHNAALGTFHWQQLKITQPRPMKLALLLVENSRLPQSGGRGGNVILPLYPWGHGRYGRTEEIFISRTQSTFDLGSLLKMTQFLRVEPRVEPDLRPGDFVVRRWGKTWSLETQLVTYNGSATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V458</accession>
    <name>A0ABR3V458_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neutral ceramidase</fullName>
            <ecNumber evidence="3">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000396">
        <property type="protein sequence ID" value="KAL1836557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="106"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="654"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="830" mass="91479" checksum="4F13A616F800FAC8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4A4</accession>
    <name>A0ABR3V4A4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="16">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VTJ49DRAFT_5398</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="16"/>
    <dbReference type="EMBL" id="JAZGSY010000442">
        <property type="protein sequence ID" value="KAL1836236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047325808" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="18">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="19">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="254"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL1836236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="343" mass="35769" checksum="85ADCD9AF1BB06B9" modified="2025-10-08" version="1">MAPKTSSLLASLTGAALVAAHGHVSHIIVNGVQYRNYIPTTDFYSPNPPVVMGWSALNQDNGFVEPSNFGTPDIICHKSARPGGAHVTVAAGDKITFFWNDWPESHVGPVIDYLAACNGNCETVNPSSLRFFKIDGAGYDQAARTWAADVLRANGNSWTVQIPSDLKAGNYVLRHEIIALHGAANANGAQAYPQCINIRVTGGGNNLPSGVAGTQLYRASDPGILFNPHVGNPNYPVPGPALIAGAVSSIPQSRVTATATGTATRPGNDNNNPAPTPTTTSSRLTTLTTQTTPPPAVTTTAPPPSGATQSRYGQCGGNGYTGPTVCASGSTCQRLNEWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4R1</accession>
    <name>A0ABR3V4R1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">xanthine dehydrogenase</fullName>
            <ecNumber evidence="5">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_4708</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000370">
        <property type="protein sequence ID" value="KAL1836749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="20">
        <location>
            <begin position="260"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1836749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1377" mass="150764" checksum="0893602E05A0F06A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V567</accession>
    <name>A0ABR3V567_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000351">
        <property type="protein sequence ID" value="KAL1836907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF21">
        <property type="entry name" value="GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="250"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1556"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1317"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1330"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1556"/>
            <end position="1567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1576" mass="174973" checksum="DF61B9C27AB6414D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5A9</accession>
    <name>A0ABR3V5A9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000403">
        <property type="protein sequence ID" value="KAL1836493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="12807" checksum="26DDEEEDD3B39DA7" modified="2025-10-08" version="1">MARETRSSTGNSKPRVIPVVDTAPVIKRKSAPKKKATPAAGKGKGAAKPKATTGAGGAGKGAKPTGVKKTKAPGKKNGASKGKAAALEKAVKAETKTEETPDEKADKAEKEAKPKAPAKKKDAPATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5F3</accession>
    <name>A0ABR3V5F3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">VTJ49DRAFT_4791</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000379">
        <property type="protein sequence ID" value="KAL1836681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="174" mass="20793" checksum="1E515C4845BD3545" modified="2025-10-08" version="1">MKAYYYDNLPGDQRLPHEDTTQPPLTESELARIGVVYYKINDIARVDELAASRGYKNRDEITVSPERMGDAYESKVRMFFDEHLHEDEEIRYVRDGRGYFDVRDRDDRWVRIAVEKNDLIILPAGIYHRFTTDESNYIHAMRLFKEEPKWTPLNRSEELSTNPYRKEYVSQYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5G1</accession>
    <name>A0ABR3V5G1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000340">
        <property type="protein sequence ID" value="KAL1837000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044966816" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="445" mass="48596" checksum="EECE3098387C5D6F" modified="2025-10-08" version="1">MKSAAIFSALAAMSAVQASPAAGPKAKRSVTPITVKGNAFFKGNERFYVRGVDYQPGGAAGNVDPLADPKVCKPDIEKFKKLGINVIRVYSTDNSKDHDECMNALADEGIYVVLDANNPNYSINRDNPHPSYNAVYLQSVFATIDAFAKYDNTMAFFSGNEVIHDHLNTTRTAKYVKATDRDMRAYIKARNYRKIPVGYSAADVTDNRMQTAHYFNCGSEEERSDFFAFNDYSWCSSDFITAGWDKKVEAFKDYGIPLFLSEYGCNTKTRDFGELKALMGPEMTHVYSGGLMYEYSMEPNNYGIVKIKGGDLNNGKDQTGEREELPEFAAFAKALKDYPAPEGDGGYNPNSKASDCPPKDDHWDVDPDLPDMPEGAKIYFEKGAGKGPGLKGPGSQWASDEPAPIDNGDADSSSDKPNAAMRGVSFDKAPLVISGLAVLIGGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5V5</accession>
    <name>A0ABR3V5V5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Haloacid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000325">
        <property type="protein sequence ID" value="KAL1837134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1238" mass="133392" checksum="C96DDE798AD7198A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V601</accession>
    <name>A0ABR3V601_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000319">
        <property type="protein sequence ID" value="KAL1837192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="11"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="319" mass="35367" checksum="327970651DE13438" modified="2025-10-08" version="1">MADTDLPPPTIQTTNLTYTFPDSTPGVSNITLSLPSRSRTLLVGANGAGKTTLLRLLAGKRLAPRGAVRIAGLDPFQDALAGQHGVAYLGLEWVLSEVVRRDVSVKELLKSVGGDVYPVRRDELVQVLDIDAERWRMHAVSDGERRRVQLAMGLIRPWRVLLLDEVTVDLDVWSRAQFLNFLRKETETRECTVVYATHILDSLAGWPTHLVHMHLGTVKEWGLAEEFLRKGEEEKEREGDDGLGASGNSRLGELVLRWLRDDLRERGPRNQVKRGPEGLTYAVGGLGGYGYEPQGGKEGAEVLEVAEGPQEFVDDLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V604</accession>
    <name>A0ABR3V604_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000358">
        <property type="protein sequence ID" value="KAL1836851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="210" mass="22436" checksum="659CDF51B13EAF65" modified="2025-10-08" version="1">MCYFKRAVWDCGCPLGIAPARPCEHKGTPACQRRHLLEKLRANIACPKHMPPGGYPKRKKWVRWFYKVHPDGRVTRFLRKKKKAAEKGGDAHASAPVVAAEATETTTTTPVKQTLLRPTTPDAPALSGLFPPRRGRSASVSSVASVATTMTLGRETIEHGNGTGEVGVMTTATGLPTPQSMDSTTSARCGLPGLRAAPGSPSVDRAARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6I8</accession>
    <name>A0ABR3V6I8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000315">
        <property type="protein sequence ID" value="KAL1837235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="200"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="685" mass="74445" checksum="7926076E248344E6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6M6</accession>
    <name>A0ABR3V6M6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000328">
        <property type="protein sequence ID" value="KAL1837116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="650" mass="70357" checksum="A0435463B0491778" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V720</accession>
    <name>A0ABR3V720_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin Pom152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000281">
        <property type="protein sequence ID" value="KAL1837578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="4">
        <location>
            <begin position="35"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="6">
        <location>
            <begin position="171"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="422"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="530"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="649"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="734"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="853"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="1140"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1245" mass="138925" checksum="BF9341F5445F64B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V747</accession>
    <name>A0ABR3V747_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000280">
        <property type="protein sequence ID" value="KAL1837589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="431" mass="48030" checksum="B39EAEC42BD9BE16" modified="2025-10-08" version="1">MATPEVKSLFNVSVTTKEIIFRDEVDPSPWTADSWTSKVAAQAVQYADIDGLRQTCSLLRELPPLVSDWEVDQLRERLSHAALGSGFIIQGGDCAESFADVKWDIVKRKVDLLFAQSQILEEALQVPTTVIGRIAGQFAKPRSNLFETLPSGEVVHAFRGHNVNSEDPSEREPDHRRLLLGYMYSAAAQRMLRKMPLHLTSHASDGKKVEFSLFTSHEALHLPYEASLTHNRYNLSATTIWLGERTRQLDGAHVEYARGLRNPIGVKLGPTATPEDVVALLDVLADPAAVGKVTLITRFGRGRAQTVLPPIIDAVRRSGHIPLWMSDPCHGNTFSSPSGIKTRRVEDMLTELRETYTVHRACGSFLGGIHIEQTGDNVTECLDETVMGRDDEYLGTCYQSLCDPRLSRDQAIRLIEEFADFVRAARGRDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7M5</accession>
    <name>A0ABR3V7M5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000296">
        <property type="protein sequence ID" value="KAL1837421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="260" mass="29767" checksum="9D4DF44175163B64" modified="2025-10-08" version="1">MSKPEFHRADERRFLDERGTSGPLAPNGLNPATILEKAVRERIVDSYFYKEQCFGVNEADIVDRVVEHVDHIGGVTGVAQRPTPFLCLVFKLLQLAPGDDVLDEYLHFGGEKFKYLRALAAFYIRLTRTDRDVYARLEPFLEDRRKLRRKGRNGTSLTFMDEFIDDLLTKDRVCATSLWKMRPRDILEDLDLLEPRVSPLGSLEDLLEEEEEEEREKEAAQNGDAREESGSVQVKVSLTAQVEIKISVEVPIPREGTFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Z0</accession>
    <name>A0ABR3V7Z0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_3244</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
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        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="689"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="693"/>
            <end position="750"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <end position="112"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
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    <sequence length="1173" mass="132973" checksum="8921BDFF939E5169" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Clum A."/>
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                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Henrissat B."/>
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                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Tsang A."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
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        </location>
    </feature>
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            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
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            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
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            <begin position="594"/>
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        </location>
    </feature>
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        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
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        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
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        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
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        <location>
            <begin position="673"/>
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        </location>
    </feature>
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        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
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        <location>
            <begin position="893"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="932"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1838073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="100043" checksum="23B7ECAB42113036" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V8K9_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_3001</name>
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        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="252" mass="26967" checksum="5D95149A58CAA1B2" modified="2025-10-08" version="1">MKVVPNPASRARPRTHSVSFIPHAASAPRSGVSSVHVHHHHMHVTRRTTGPRAAIFDSKINKPAQHRKVGLWLESIDASAAPPGSPSLSPVAPSLPSPNPGRRRSMSSLAWSDRSHPAWRPDSPRTPLADITPLVLGASYSSESSASASFYDSQATEDEIPETPQLPEFPTLSSDGQAQRLVPSLASAIDLLTADEAKNLLLVSAQSNMSVAAAIKELALSRMHPVNRPTPPTPTPVPARRNSLADTILFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Humicola insolens</name>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1838242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="23"/>
        </location>
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        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1838242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="189" mass="21719" checksum="2EF41DDFCBC8F1A6" modified="2025-10-08" version="1">MSSHRQNRVGRHRPRPQRHHHRHHHIADLLPLVPEVADYPPNHLVLQLNMNLEDDTDPVQADAVGRCVLGVVSSLYSAPVTLTQVVAQASSHTRRRRRNPRLQQANRAEQVPAQLTVLHLPPFEEIFRPRHQFKQQAEDGEMPELGEDVQKEVVVKTEDGEASLPNREEEEGPRIKREDWQDGLDAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V978</accession>
    <name>A0ABR3V978_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2706</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000217">
        <property type="protein sequence ID" value="KAL1838394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="297"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="554" mass="60200" checksum="3AF0B432A6263216" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V984</accession>
    <name>A0ABR3V984_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000216">
        <property type="protein sequence ID" value="KAL1838403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="487"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1586"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1863"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1231"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2128"/>
            <end position="2188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2200"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1241"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2314" mass="259268" checksum="B75AD4EE18381766" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9A4</accession>
    <name>A0ABR3V9A4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1770-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000244">
        <property type="protein sequence ID" value="KAL1838016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22796" checksum="0A387FE73A4A3B50" modified="2025-10-08" version="1">MSSSIPLQLAETVQTAHIQRHPSPDHDLNPSTAASEKQPVTLEPVGAGKTEYSSISEEEEDTTAAGPDDVDDEEEDELDTEDEALYREGAAVIPRPRGRRHHLPPMPDLRFEQSYLHSIRNADTWWKVVLITVRDQVMMPFMQGILYNLGLCGWHHWNRNARIHGSSVGARLRRWWYGVNNWAIPPEKSVRRLNLTRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9D5</accession>
    <name>A0ABR3V9D5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="172" mass="18208" checksum="96A7B4B332D7C3BF" modified="2025-10-08" version="1">MSDAARWKATVYVGGLAAGVTPTILREAFLPFGEIVDVSFPRNEPNPNKPNNNPNAVQASAAAAAAGGDTHRGFAYVEFEDPDDAREAIDNMDQAELFGKVIRVSAAKAPKSAGAQALLNARTAVWEQEGWLAEHAVSEEDRQAAEIANLNSVPEDPMQGLEGLDVAGPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAG9</accession>
    <name>A0ABR3VAG9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000191">
        <property type="protein sequence ID" value="KAL1838829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="645" mass="71469" checksum="113A990229B86D2D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAW7</accession>
    <name>A0ABR3VAW7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000193">
        <property type="protein sequence ID" value="KAL1838780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045085553" description="Glucoamylase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="11">
        <location>
            <begin position="529"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="639" mass="68827" checksum="BD9BD5088D6720F9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB43</accession>
    <name>A0ABR3VB43_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Chorismate synthase</fullName>
            <ecNumber evidence="3 7">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="7">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="3 7"/>
    <dbReference type="EMBL" id="JAZGSY010000194">
        <property type="protein sequence ID" value="KAL1838772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="427" mass="45477" checksum="18783F5E6D96B97D" modified="2025-10-08" version="1">MSTFGEYFRVTTYGESHCRSVGCIVDGCPPGMELTEDDIQPQMTRRRPGQSAITTPRNEKDRVMIQSGTEFGVTLGTPIGMLVLNEDQRPKDYGNKTMDIYPRPSHADWTYLEKYGVKASSGGGRSSARETIGRVAAGAIAEKYLRLAYGIEIVAFTSSVGNVHLFPPTPEHPSPSTNPEFLSLLQTIDRKTVDKFLPVRCPDDAVSRKIEEYIAGFRDRNDSIGGTVTCVIRNAPSGLGEPCFDKLEAKLAHAMLSIPATKGFEIGSGFGGSELPGSLHNDPFIPATGELPPSVAESGAARAGFPRPKLTTKTNYSGGIQGGISNGAPIYFRVAFKPAATIGQEQVTATYDGSAEGILAAKGRHDPCVVPRAIPIVEAMAALVLMDAVLAQQARHTAKSLLPPLKQTINSGKPAGNGVTEAEVGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB91</accession>
    <name>A0ABR3VB91_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000201">
        <property type="protein sequence ID" value="KAL1838661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11962">
        <property type="entry name" value="SH3_Abp1_fungi_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11961">
        <property type="entry name" value="SH3_Abp1_fungi_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035719">
        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035718">
        <property type="entry name" value="Abp1_fungi_SH3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="651"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="745"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="712"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="803" mass="84208" checksum="63F509F2E1B80801" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBA7</accession>
    <name>A0ABR3VBA7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000200">
        <property type="protein sequence ID" value="KAL1838666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="488" mass="52564" checksum="977F51506BD59CC4" modified="2025-10-08" version="1">MRTHNGPAVLSSAKITKARGKVKAVKPILKKLSHSEKNSLDLDQGWDEQQIEQLEVGGGTRDDGGYGGASFYYSGQARDVTFSTAGEGRGGLRFPQHGRSASQASAGSGARGPFVHPFAQTPRTSTPPRSYANSVASVDNARDCSPTITERDDDDGDDSFDTCTSYLHSHSHSHSYSNSHEHASATATSSQSNLRRPSLNSQRTASFPDYSGSKPPSLRINTGNRSISGTTATSSRFAQGSLPTASSVSDLVDSHTLSVSLTGTLDSPTGSLGAGSVQPPPSQLSPLRASLDMGSFPRLRAKSEMDTATRVETIRAARRKFEERERAKEEKYDREMIKKRERRDTKEAARIEKGEAPSRPKKTATGLSTVSEPPSSSVARGRLLGHGGVAVGSIGRRRHTDLPTSTSAKKSTSDSARMSEKNSDFAARPYESSSLAFATPPAFGPTAEDVHFEQATPRRGSSAKRKTQGYWQGFLLWLRTKLLRMTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBB2</accession>
    <name>A0ABR3VBB2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000191">
        <property type="protein sequence ID" value="KAL1838832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57626" checksum="73B8A923B9E20A80" modified="2025-10-08" version="1">MPAVLAVLDALQGRLPLVVPTLAAVLVVFIAQYVLNRTPLVGVPLVGQDLGSDEKRRQTYFANASGLYLEGYKKFKDSVWRIVTSNKFTVIVVPPKYLEELRKLPDDVVSFDDAIAQTMHAKYTELPTGNNLIPHTIKTSLTPSLVRLNPTISDEVDDSIRKEMPPCDDWTSVNINQKLLRIVALVSGRVFIGTELSRSEEYLDAAINYTVELMNARNAVEKVRSWMRPFVAHRLPEVKALRERLAAADRFMRPVVAARQKMSDDEKPNDMLQWIMDGQIKFKQYTTEELARLQLALSFAAIHTTTLTATNVFYSLAAYPHYTSELRDEIRTILAEHNGAFTSAALQAMKKLDSFIKETMRLYPPGEVTFTRKVNKPFQLSNGQLIPAGVLIEVPAGAISRDPEVFEKPDEFDPWRFSRMREQARAKGEVEVAAQNQFVSVNPGVMTFGWGRHACPGRFFAANEIKMIVANFILSYDMRLPEGVTERYPNIVFGTQNIPDPTKELLFKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBE7</accession>
    <name>A0ABR3VBE7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000175">
        <property type="protein sequence ID" value="KAL1839097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58769" checksum="2CAB4CC1A7B68E97" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBK3</accession>
    <name>A0ABR3VBK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="62"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="284" mass="32026" checksum="B00DA9B3135B2716" modified="2025-10-08" version="1">MAIITFIPGLEVTIAVEGQALQEYDNPEHARPEFPAMTPDLFDLPDGHSKLGKAEASDLPTEVIQQQKELAKDYGTIRVEFFRMTTCGIEPSRSCGISSAPSRPSPTPFSAPDPMEEVSEKAFKKGRAVDCVTKMVEVDLPSKRPLPRLKVAPKPRRAPKPKQIRKPIEAPKLKGTFTDPRKRPFAVFEFRYRSKEGLMREAVIPRPTRVDQLQDLSSEELRKRLAQMMEVNERLAEQATRRNATDAMATVRGKRPAEDDGEIMAKYKARRLNNGRLEIDLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBV2</accession>
    <name>A0ABR3VBV2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000201">
        <property type="protein sequence ID" value="KAL1838653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="603"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="967"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1032" mass="113931" checksum="DE4359396A720AFA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCL6</accession>
    <name>A0ABR3VCL6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000149">
        <property type="protein sequence ID" value="KAL1839588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="204" mass="21977" checksum="A8B6DDF024D7A6D7" modified="2025-10-08" version="1">MGFLLSRPSRNADTDIDDAESGRSTLFLSPSLLTPTDTPLGYGDNYSGPTQHHVIYYDRETLDRALERAQRTRPVRKGSQPVAIPSWEPRLKHCSGGESAGDGHSNIAALVMVDAPEEFVLCAAPAAAYPAGDDDEGQVRVAIVPGIWVFQRGHSIDNHGIIIVFVIIIQVELGIEIPVRTLDVPPQLVLLAPSGAAYASAQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCX4</accession>
    <name>A0ABR3VCX4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000152">
        <property type="protein sequence ID" value="KAL1839533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="210" mass="23445" checksum="E46CB9AC9E16037A" modified="2025-10-08" version="1">MSATTTAPASKPAKLPVTVDKPTPYTFDLGLLLANDPNPVSVPQTSDRATLESHLASVARDGAQVLINQLLTTCAISSTPQGVLLNLPPATTPLPREKPVPDTSNNGKPETKWSAFAKRRGIKPKTREQRRNLQYNEATGEWERKWGYKGANKAGQDDPIIEVKAKDEEKRMAEGRSVRGDKRREIRERVKRNERRMRRNLRNQEKAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD31</accession>
    <name>A0ABR3VD31_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000165">
        <property type="protein sequence ID" value="KAL1839306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="535" mass="58671" checksum="9FE444B4276863A1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD46</accession>
    <name>A0ABR3VD46_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphosulfolactate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
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        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35167" checksum="C099B230F1A3681B" modified="2025-10-08" version="1">MRPTTLRPLSTTALLRKKDTHAFHNPSILLEDEKSGFGFIRHNARPAKPRKVGVTEIRGPYYSAMGKRYLQDVLETMGHHVDGLKFAGGSFSLFPEDKLRELIDLAHEHGVYVSTGGWAEHILLQSSPTTAIDRYLAKCKSLGFDVVEISTGFLSLPPDDFVRLVDRVQAEGLKAKPEIGIQFGAGGDTDPAALEALAGGTSGGAGGGTSPASKIVDLGKRFIEQCGVERIMIESEGITENVGDRWRTDVVRAVMEGLPPEKVMFEAAEPKVFNCIPSPDTKKGDEGDKGKAPATAAKNEKEPADDEKVAETPTKKKKAEGEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDT1</accession>
    <name>A0ABR3VDT1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitotic checkpoint protein BUB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37635" checksum="7F54AD15418FA15B" modified="2025-10-08" version="1">MAPATQFEVAQPPQDAISALAFGPGTSRRLLVSSWDKNVYLYEVSNNADEATLVRTFEHRAPVLDVCFGASPDEAYTAGIDHQVKKIDLATGDQTVLSKHSEAVRCVVFSAQHSLLISASWDCTLHVHNISQPSQPPLAVPLPGKPHALAASPTKLVVAMTARLVHIYDLPTLASAVDSQQPPQPWQQRESSLKFLTRAVACMPNDAGYATSSIEGRVAVEWFDDSPESQARKYAFKCHRQAAPEDEGGGDVVYPVNALAFHPVHGTFASAGGDGTVALWDAEAKRRMRQYQRFPESVAALGFSGDGRLLAVGVCPGFETGMEDYSGEGRTKLFIRELGESEAKGKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE27</accession>
    <name>A0ABR3VE27_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000160">
        <property type="protein sequence ID" value="KAL1839386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="53957" checksum="6E54F3D56B6C3C59" modified="2025-10-08" version="1">MTQSNPVDQARRNINSALGLVRHGRRRAGRAAHAVVSSKWVQRLVVGTTLLSIVGALLYVPAALGYLLLYYKFLPELETNVPVHLQYGAGPHPFGIAPLDGLVTRQPYDLTVSLTLPRSPPNLGRGNFMIALHLLSQTDPTASPKTYPPLPYHLPDRTPVTAPGPPPTANEPLKPSLEALHPTRLNLPSFLATHTVLYTTTRPALIPYVDPLADLASRLLFLPYHLFAAHPKTATVHLTVPMAEDLVFGGKVSSLSSKPQELLSRVPERVLLEVQAGQDLQVYDVSVKVVARLKGLRGVMYRWRATAFVLFTAVFWVAEMAVVGTMVMCVLGWDLGGLLAGAGKEESEEGDGGGEEDGNSDDDDNDWKRKKKRRRVESSSEEGQGSAWERGRLTTPTKRESTPPARWSSTSSSPTRPGKEGKLKKEEESEDTSSELYKVPPFESGGKGKGKPVSRKEEEKSQSNDVGAGTSYKGHGEGNARKRTVTVTPGSQEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE33</accession>
    <name>A0ABR3VE33_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribonuclease H</fullName>
            <shortName evidence="10">RNase H</shortName>
            <ecNumber evidence="4 10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 10"/>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="12">
        <location>
            <begin position="175"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="327" mass="35323" checksum="A7C327ADA3B06FC0" modified="2025-10-08" version="1">MSSPGKKRGAPGTAGPEGGSASKKRKMDSTLSSSGGKYYAVRVGAKPGIYTTWATCKQQIDGYKGAQYKSFVNYEDAAAFVDGRSPPSGAADNKPPRFYGVAVGREPGVYTEWSKVQEAVKGWKGPKYRKFDTRQEAEEFVRTGKVPVVTATDGDTVEESPAKKTKTTPNASAKRNPVVVVYTDGSSRGNGKVGAAAGVGVYFGPNDPRNISERLEGLPQTNQRAELTAILRALESVDLDQDLEIRTDSKYSIQCVTEWYINWERNGWRTQGGPVKNLDLVQGVRKKIEEREAHGAGTQFIWVKGHATDPGNIAADRLAVSGAMKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE38</accession>
    <name>A0ABR3VE38_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="16779" checksum="F38C2CE636EBDAD2" modified="2025-10-08" version="1">MASFTLRSVRRAPMLASALRRQALAAPQFHTSSPTQGDVSSPKSAEGPSATSGGSRSKEAVETGSSPTAGAILPDALATGDVRGATGGGPPLESSRSPPPQPKITNASVPGHKVQLTPEQQAEVDEHNREFEKKHGRADPAENDKVDKSFWSGRGSRFGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE46</accession>
    <name>A0ABR3VE46_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000133">
        <property type="protein sequence ID" value="KAL1839968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="2">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="268" mass="29825" checksum="0583AF46157C3848" modified="2025-10-08" version="1">MATSTAQMKPSDPFPMAPFQGGKRKLPSDTSAEPISNKRQAAGRQLETQAEELRAHNSTTSQPPSSGNNSPYTQIYRPFIDRLSSNFDVKPMSVMPSTSIRGHVDRALSHLGRFSPWDLSIRPGVVVLCAKSPAASKLVTIAELVRRRIGESEQKWYQYNVVSETVTIEEAGVQMWREPPSVVEDTVMGGEAEEGEEEEDGEYFETMTRPTTIHDEAVHPPRTRYTAYVTVLLSRVPVAELQSDPCIAVQTNEQTIEYLRKKKMGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VED7</accession>
    <name>A0ABR3VED7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Auxin efflux carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF4">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="49777" checksum="8731DD14A6032394" modified="2025-10-08" version="1">MAAGLLQAFVAAIQASLCVLLVMFYGGLAAHLKLIDRANTRPISKLCVRIFLPALLISKVGAELQPSKAYRYLIILIWAIACHIVSFLAGLLGHRVFGMPDWTTPGILVSNTTSYPLLLITALEETGILESIIVADETTKDAIERAKSYFLIFSTVSNCVTFAIGPRLIDSENPPESEENGEEDGKALNGNGAPSPVDVEANEQTRLLDTPMPNSIRSPGPIRRDSFFFARPRPDQAPAPQPDNRRPWFVPRRRWNLFSPRTKWWFLLILDFFNAPLLGAIAGAIVGLVPFLHGAFFNSSDDGGIFAAWLTSSLKSVGELFVSLPVVVAGVTLFCSMRDAKRNHESTVTSMPWGAVSYILFVRFVAWPLVSISAIYLLATRTGLLGTDPILWFCLGIMPCGPSAMKLITLVQVARGTPDTEKHISQLLTISYLISPILSLTIAGSLIASQRAIPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEK1</accession>
    <name>A0ABR3VEK1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Translation initiation factor eIF2B subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_583</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000119">
        <property type="protein sequence ID" value="KAL1840294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056818">
        <property type="entry name" value="GlmU/GlgC-like_hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24894">
        <property type="entry name" value="Hexapep_GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="14">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like C-terminal hexapeptide" evidence="15">
        <location>
            <begin position="432"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="298"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1840294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="534" mass="57712" checksum="9677A3DB9AA8CFC9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VER2</accession>
    <name>A0ABR3VER2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000131">
        <property type="protein sequence ID" value="KAL1840002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="171" mass="18632" checksum="A8B3DB0BD343830E" modified="2025-10-08" version="1">MTHGHGLQPLQRSAQLSSRRPPTHPSSPPSISHAYPTPLSYSQDHTHSILPPFHPFPPLLQLLPLHRPKLAQRLQLAIPQLDARRANHARIDAQRGRQVLVGFGPGIVAQHEVVALGIPRLVARDGPREVEDAPVGHVADHAALAEDELACGEDDSVRGLGLVCRSGERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEY0</accession>
    <name>A0ABR3VEY0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000114">
        <property type="protein sequence ID" value="KAL1840413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="163"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="359" mass="38946" checksum="16617BD906D1D130" modified="2025-10-08" version="1">MTGVALLGAGIFAREQHLPAIESTPTLALKAIYSRSRRAASALAALTRNPTAIDVYFDVDDSTSTSPEADKSLDALLQRTDISAVIITLPIVHQPHVIEQALKAGKHVLSEKPIAKDLAEGQRLIGLYEALPQAERPLWGVAENYRFMDSLRYAAEKVREIGGNLLAFRLMRYGFVAEGNKYFATEWRKTPAYQGGFLLDGGVHFVAALRLLLNAADDDIIKVAGFSALLEERLPPLDTVHAVAVTWRGVAGTIAMSFGTEFKSGTEVEVITTNGVVVWTPDEVRIVARKRDGDGKEEDTRRFPYSTGVTNEVGAFARAIETGETDQGLMPREALKDLEIVQGLLESGSAGGRVKIAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFB2</accession>
    <name>A0ABR3VFB2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_599</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000119">
        <property type="protein sequence ID" value="KAL1840310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047011757" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1840310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="264" mass="26849" checksum="97474A4C9D73B842" modified="2025-10-08" version="1">MKLTGTTLFVLVGATTVVAAEFPENMPDCGKVCGTNMIAKALEFECNVSDIACLCQDLRFGWGIHDCSVQACPGVEQANIVINWGKDLCSSAGHPIDIPTATTVGFGEPEATPSTSEVVTTMTTDDITVTTTMVTTITDSDEEPSAITTSTWTTVVTSNGAEETITGETTISGVGGVPVTTSESEDSATTITSPIVSTDTSTFETTIGTSTIVSSPTDDALTSASSTLSSLTSQAPDVTDSGAQATAAPVFGFLAAAGFAAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFI3</accession>
    <name>A0ABR3VFI3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000113">
        <property type="protein sequence ID" value="KAL1840433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="456" mass="47899" checksum="CE9C4A8E6DF1DBB7" modified="2025-10-08" version="1">MLDAPALTEEKVLVPLVTGNQLVDAHMDIDAADFGTAASMEITDAPHEPLLSMGSVFSALPSLPPVQAPVSTAFADTPVEDENRSPFLAPPQPAVAHSASTSGPTPVFAPLDNTAMMVGNELPLVPTPEPVAAEPAPTFDPYPVGPLDNTVKVGNGLPQLTAPEPVAAQPVPAFDPAPVSAALDDTAKKVTSQEQAAAPPEPVTITYPKRPAVRHFSGFSIAPPAPKEVPIDPALLDPALLEAPTPAPVNFGLAAPANAPSNSAAAAPVAFSFDFSAPGPSTSPVRNAKRRSGARKTQAQAPAKAPAAAPAPVLPGSATMPPADPKGKGKATFTESTFEPDFDYLVMNAQQWTDLATKWIHDCYNIMFTSPVFAAVDRNWMIMWRNKALRLLTTEFDGDLSDIEMDSEFLSSKTKRFFQLTMLESGGPDADGRNAVLRHVKDLAAMEGIDVGVIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFN6</accession>
    <name>A0ABR3VFN6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_234</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="12">
        <location>
            <begin position="9"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="11">
        <location>
            <begin position="396"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="63184" checksum="B86D7A35E347ECEC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFP8</accession>
    <name>A0ABR3VFP8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000134">
        <property type="protein sequence ID" value="KAL1839941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12532">
        <property type="entry name" value="RRM3_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034862">
        <property type="entry name" value="Fungal_Mei2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="503"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="699" mass="77135" checksum="2A323E5670D3B0A1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG02</accession>
    <name>A0ABR3VG02_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="705" mass="79396" checksum="64FE36F142E8F0E0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGS2</accession>
    <name>A0ABR3VGS2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="6">
        <location>
            <begin position="69"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="764"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="823"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="890"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="932"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="944"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="991" mass="104708" checksum="66095F39DEDCCF63" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHM7</accession>
    <name>A0ABR3VHM7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="197" mass="21382" checksum="A8E5B4272827696C" modified="2025-10-08" version="1">MRARISDNPFRDVAAGPEARIEGMAVNAPENRSPHPSPVESLGEPGSQAEAKQANQSDGTSESGHAASQQADEQQKGKDEKRTRRTPKWIFSLFSKKISREDGKGKEEETAKAGDSQTQWRAITQMPWRIGVTARHHAAAMPSRPCSARLCLWLKPVSVAQSRRICNKPKTQGSPGRSAPGAQKIHPSPAPVPSTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI87</accession>
    <name>A0ABR3VI87_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cellulase</fullName>
            <ecNumber evidence="3 10">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_6971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 10"/>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047049734" description="Cellulase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="260"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1841542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="296" mass="31278" checksum="5B752481C4F3E973" modified="2025-10-08" version="1">MRSTPVLRTAVAAALPVLALAADGRSTRYWDCCKPSCAWPEKAAVNQPVYACNAQFQRITDPLAKSGCDGGPAYSCADHTPWAVNDDFSYGFAATSIAGGSEASWCCACYELTFTSGPVAGKKMVVQSTSTGGDLGSNHFDLNIPGGGVGLFDGCTPQFGGLPGQRYGGISSRNECERFPEALKPGCYWRFDWFKNADNPSFSFRQVQCPAELVARTGCRRNDDGNFPAVSPPSQQPSTSSTSSSSSTTQQTQPTSPGGCVAQKWAQCGGNGWSGCTSCEAGSTCTKVNDWYSQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIM6</accession>
    <name>A0ABR3VIM6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="377" mass="41074" checksum="C104A227259357E0" modified="2025-10-08" version="1">MGLRDKFRRSRGPDDDDYNPPTPPVTFIRSDTHGAEVIRPPSLDDHPFPGGHDGFLSPSDPRPDSKQRRSLDVFRSSNRPGRSHSASSVSPGRESTAKRLSQRLHLSRSPASSDNVPRDLPDIVLPEGTREDDPDAAADRESQWEKRATLLAKENEKRRSRPPTPVHAAAVPPQLPELNLSATTSNNNRSPSPARVVSSKAIDEDIQEAIRLHEAGELDKSTALFARLADPKGANNPLSQVLYGLALRHGWGCQPDPARAVSYLSAAASNAAEVEQLALQAGLKKGGAAKGELVLAIFELANCFRHGWGIPKDPIAAKQYYETAANLGDTGFCGLDAMNEVAWCYLEGFGCKKDKFTAAKYYRLAEKNGNKIIGNTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIP0</accession>
    <name>A0ABR3VIP0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pisatin demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF77">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="64240" checksum="C4A140EAEDBEA83B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIP3</accession>
    <name>A0ABR3VIP3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="87"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="463" mass="49463" checksum="4D4BA2514EB8E371" modified="2025-10-08" version="1">MSLRDHPRVYGTAALAVAFIAGVLVTLGFKDLYPELEARYQRRKKSAYRHSIFDLIGPVSLEDRETSSSHGDLSTFDRGHGIVDGIEGTIGNTPLIRIRSLSEATGCTILAKAEFLNGAGGSPKDRVALSMIQAAEEEGLLVPNRGDVIYEGTVGSTGISLATLARARGYRAHICMPDDVAIEKSDLLRHLGAEVERVPVAPITDPGHYVNLARARARAHSASPDTPSRGVFCDQFESLANYTAHMRTTGPEIWAQTGGGKLDAFIAGAGTGGTLSGVAKYLKEERGLGSALRVVLADPQGSGLFHKVRHGVMWSPTEREGTRRRTQVDSLVEGIGVNRVTGNFEVGRPLVDDAVRVTDEQALRMARWLVEHDGIFVGSSSAVNCVAAVVTALGLPPGSRVVTILCDSGARHLSKFWKHIAAMGLEDGGAGEKKENDGPGQGDPSLRGKDLLDVLGITHLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIW4</accession>
    <name>A0ABR3VIW4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="90"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="556" mass="62615" checksum="F7250CD04C82933F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ18</accession>
    <name>A0ABR3VJ18_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_6660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF20">
        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1841746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="296" mass="32069" checksum="8D69128CEBD48BE5" modified="2025-10-08" version="1">MEYSSNQNVARKRVSLGNIIGDPFALATISIAALAWIISFVSTILAHVQVPKDFPLYTYWSLVFFLGIIVFIFIVVASDSTQTYHVAIVGYLGCGLVLSTSAVNGLIHTSQGAKEAAAAGFILLSMVTIVWIFYFGSAPSAVPRAYIDSFALAKESTSANRQTMTGAYATRRPETSTSVQPPQMYTAQLNGLENPSPVGGMTSGMRDSTVPGFSSQAAQKTSPQTLNPDAEVVPPTEYPYRARAIYSYEANPEDANEISFSKHEILEVSDVSGRWWQARKENGETGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ67</accession>
    <name>A0ABR3VJ67_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="15" type="ORF">VTJ49DRAFT_6325</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000059">
        <property type="protein sequence ID" value="KAL1841934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5044915138" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045477669" description="Phosphatidylserine decarboxylase proenzyme 1, mitochondrial" evidence="14">
        <location>
            <begin position="19"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044915137" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="507"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="119"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="506"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1841934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="551" mass="62081" checksum="0A16233E652672FB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ88</accession>
    <name>A0ABR3VJ88_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000064">
        <property type="protein sequence ID" value="KAL1841768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF66">
        <property type="entry name" value="MFS HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="73"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="621" mass="71271" checksum="9B1EB1648D7AB221" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJZ8</accession>
    <name>A0ABR3VJZ8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="3">
        <location>
            <begin position="125"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="407" mass="43873" checksum="571B750A468C9DE6" modified="2025-10-08" version="1">MEVASRSRLQDTRVKAEDDGDADKPTYRSWKKKYRKMRIIFDQKMHEGEELHRLEQKALATAKRLAVQKDRLLDILLDVNNSRQIPPEKRIDLSLDPPSDAENDALLLDIDRPSTPPPGPPPATSYKKLLKEVPHYTFASAAEHCPEFLADLEAGRDSPADPAQGASHPPSFLTADDIDNYIWELDTQLANEKAVAAAAASSSEPNQGPKKDSKDAVPSLLPTLAPLAHANNHQTPRDTQRDFALRNPVSVYNWLRKHAPKTFLQDGEHEKETSGGKENGDDHPGSARRGKAGGDRASRPEKGSSSARAATKRASAAHARSAAAADSFEDPDDDASVVGGPLTPVAGGSKGAKRKRVVDDDPGYRPKGGSSRPSKKKRKSDGAEKTPSGGKGVKKSEAAAAAAGYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK45</accession>
    <name>A0ABR3VK45_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6123</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="524" mass="60990" checksum="6BBC191C31F59991" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK77</accession>
    <name>A0ABR3VK77_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="767"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="829"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="949"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1028" mass="112667" checksum="C1294A19789125B2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK94</accession>
    <name>A0ABR3VK94_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_6548</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045522577" description="Extracellular membrane protein CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="18">
        <location>
            <begin position="114"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="367"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1841795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="50143" checksum="DFA1DA8B4554AF70" modified="2025-10-08" version="1">MRAAARFALAFLAWAAVVFAQGQTIPQCAAPCIVNGIKEFCGNAPNVTACMCGNEALQESASACILNSCTMKEALVAKNVTSTTCGVEIHDVAGTYAVISIILAVISFSMAAVRLGFKLIVTRSFSADDYVMIAVLLVAIPCVLVTHYGTTANGVGRDIWTLTPDNITSFLYHFWWMAVLYFALVSLVKLCLLLFYLRIFPSQGVRRLLWGTVIFDVLFGVAYVFLAIFQCTPISHYWEMWHGEKEGKCLSRSAIAWSNAAISIALDFWMLAIPLSQLKALNLHWKKKVGVALMFGVGTFITIVSIIRLQALIIFAQSSNATYDNYPVSLWSTVEINVGIIVCNLPALRLVLVRIFPALGSSTSYGPSYPNSGAGGPNSSNKLRISQGRRAGTGNLTGKSNKSAHLQSEVDSDPSKPLEIVRQQTFVVKYDDDDETSLVRMRGLDFGAQSQRSDDSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKC9</accession>
    <name>A0ABR3VKC9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="229" mass="26764" checksum="45F00055AD9A76B0" modified="2025-10-08" version="1">MASRKCNIYFVFGPEPGSYLLWTPQMFKTSKMPLALEQQLANIDKLHWAVVGDNGHVALAYRSKVPEGGEWRCDTLVISDPDKRNFHFNSLDDHIRDRIMDPTRPVRQIALGVEGEHIILRKGGDNAWQLRRNYRELSDIFSRLRRARRLKDIDFVALNPWRRQEFFLVEKDGTIHFQVHESVKQDLEEILRAHNAQRRDPRRTVKGGKGGPNGKRRWMEHHRPTAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKE1</accession>
    <name>A0ABR3VKE1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="150" mass="17138" checksum="351E6104A8D27290" modified="2025-10-08" version="1">MSIPSDAQLFEDHFVVERLGDPKYDRVDRIYCHSKDQSISMSLDINKELFPCKVDENLHVAIATSLSYDGSKDEERGWRDVAKAGTSDATLADIFDYVCYGKIYKFEDAEDGKTIKAYISFGGLLMSLEGPYKKLTPLRVDYVYLLVRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKI6</accession>
    <name>A0ABR3VKI6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="651" mass="72767" checksum="7883A48C017122A4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKP2</accession>
    <name>A0ABR3VKP2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="21"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="578" mass="62462" checksum="FCB181335F6838D1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL02</accession>
    <name>A0ABR3VL02_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046499979" evidence="1">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="130" mass="13291" checksum="279C9D12BAC1CE73" modified="2025-10-08" version="1">MVKYTSLALAAVAAFIAPAMGSPACKPKSSTTTSSTTSVITTAPDCVFRPQATWYALDSPKCDFKCPTSIPWCIADAAVTVPCGCTAVTVSPTTTTLCPTNTNNCAQCSTGWGIVTFTETGCPTPAPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL05</accession>
    <name>A0ABR3VL05_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="252" mass="26239" checksum="B24B60237F3F9DB2" modified="2025-10-08" version="1">MLGTNETREKHQRILKTPSSPQPPAETADCTVTGPGATTLPEMGREHGNTARQTGGSPGASSPDVNAIINPTPPPPYDAAQDKLHAVQEGAEPSYAAVTAGDAPASPTTSSRRRSSSGAGAGAGAGAGTRAAGGGEEEDKKKKKWVIKAQSDFYNTPDQARLVAGVSPASVVTSLMQLTATVWCAAAAGVVGWVFGMLRPITVSVMLWFEYLRFVVRRLWYYALGGIHSEGYGSGVGRMKGGGDEKKGRGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL82</accession>
    <name>A0ABR3VL82_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4580</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1842669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="212" mass="23759" checksum="6734D340C17E28D7" modified="2025-10-08" version="1">MASQYEVEHNIKPAPSTTRRRRQVDMSTFTAHLHNILPESTTTTTTTTTTRNAPPSHHHHNPHAVPNPADTSALFRLLQDQMGTLATTAPTEENRAFLRSLVEALEADVARPPRQIEGVTQAFLDGLDRVPRSRLKKEDTCPICAERYLDDPYPLVVELPCHETHRFDLECVGPWLLGKGTCPLCRKEMGKRKEVVVVDDGEEEEDGNGLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLE9</accession>
    <name>A0ABR3VLE9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="497" mass="53629" checksum="228E80D4DBA89480" modified="2025-10-08" version="1">MADVFVELSTPVTGPYKQPIGLFINNEFVPAAEGGTFEVINPATEEVICKVHEATAKDVDIAVAAARKAFEGPWRQVPPSQRAVMLNKLADLAEQKTDLLAAVESLDNGKSITMARGDVGAVVATLRYYAGWADKIEGRTIDIKPDMFHYSRREPIGVCGQIIPWNFPLLMLAWKIGPALATGNTVVLKTAEQTPLSGLVFASLVKDAGFPPGVLNIISGFGKTAGAALSSHMDVDKIAFTGSTIVGRTIMKAAAESNLKKVTLELGGKSPNIVFNDADIEDAISWVNFGIYFNHGQCCCAGSRIYVQEGIYDKFVEAFKRRAEQNKVGDPFHPETFQGPQVSQLQYDRIMGYIQAGKEEGAMLVTGGGRHGDKGYFIQPTIFADVKQDMKIMQEEIFGPVCAIAKFKDVDEAIRLGNDTSYGLAASVHTKDLNTAIRVSNGLKAGTVWVNCHNLLFPQASFGGFKASGIGRELGEAALDNYTELKTVAINMGGSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLM3</accession>
    <name>A0ABR3VLM3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="48"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="510" mass="56409" checksum="0416DC0F28F2E221" modified="2025-10-08" version="1">MKFSTCGDIDDQDQEVVRAEHAFVTIGSRTSSRCFSIIKRDVSHNKERVVILGSGWAGYGFARTLDPAKYERIVISPRSYFVFTPLLASTSVGTLEFRTILEPVRRLPGKIGFYQGWADNIDFDRKTVRVETNATEEAASKTVVPGPQGELPKPKGDMITISYDKLVIACGAYSQTFGIEGVREHAHFLRDIGDARRIRLRVLSLFEQCAYPRGADKLSDADKRQLLHFAVVGGGPTGIEFAAELHDLIRDDLAPIYPDLMPLVSITVYDVAPKVLPMFDRALAKYAMDTFARHGIRVKTEHHLQRLRLADGDLGHRHGALKIKIKEYGDNEVGAGLVVWSTGLMANPLISKLVSRTLGARPPGRNPLSGAPTPPARRLVRDARTGGLVTDPFLRARTTTDIQSAESNPNGVLDDVFVIGDCAVLESDRNLPKTAQVASQQATYLAKRLNGASSVAEKPFSFRNWGTLTYLGSWKAIHQSKADELRGWVAWVVWRGAYLTKNRTLIVSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLU1</accession>
    <name>A0ABR3VLU1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_4850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="110"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="423"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="533"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="652" mass="74391" checksum="AC163DB36F398C84" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLZ6</accession>
    <name>A0ABR3VLZ6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000059">
        <property type="protein sequence ID" value="KAL1841921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
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        <location>
            <begin position="366"/>
            <end position="456"/>
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    </feature>
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            <begin position="507"/>
            <end position="603"/>
        </location>
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            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="603" mass="65799" checksum="C6BC93BBB638A05F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMX3</accession>
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        </recommendedName>
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    </gene>
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        </lineage>
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                <person name="Kuo A."/>
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                <person name="Haridas S."/>
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                <person name="Nguyen T.T.M."/>
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            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1842876.1"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="111"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="138"/>
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        <location>
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            <end position="172"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="538" mass="58858" checksum="63D080A1DC9810A4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN23</accession>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1843200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="207"/>
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            <end position="486"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1843200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN43</accession>
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        <recommendedName>
            <fullName evidence="6">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="6">
        <location>
            <begin position="868"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1375"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1382"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1453" mass="161134" checksum="5FD037B1558F2B06" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN90</accession>
    <name>A0ABR3VN90_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19164">
        <property type="entry name" value="AKR_ARA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044480">
        <property type="entry name" value="Ara2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="447" mass="48526" checksum="3240A59ED5E253F4" modified="2025-10-08" version="1">MAESHKPRPPLHTILPPLLLGTATFNSQYVSDPESMPYRDIVARAISLGVTGFDTSPYYGPSETLLGTALNALLKPTDGSSPPVSRKSLFLVTKAGRIAPTEFDYSPSWVRYSVLRSLRRLHTPYLDLVYMHDVEFVSADEVVAAVRELRRLRDEEKVIRYVGISGFPVDVLCSLAEKVLKETGEGLDAVLSYGHFTVQNRKLGLPWVDQPNGEDQGQENEGSLLARFKKAGVQVVLNASILGMGLLTSRGIPTDPPEKATSASPSPLAKWHPSPPELRLACKDLAALAEQAGERLESVAIRWSLAEWARVGGAAGLGVNVSMLDGGETCRVGSTVCGVTSVPELEETVAEWRGVLRSIQNSSSGGAGEDDAYGSARQEKVLDLVRNKLWPALGSWLDYAWDSPGKGYKNTRNESDRGVVPDDGVIEEYEKAKQERQGAEGSVPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNF5</accession>
    <name>A0ABR3VNF5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="152" mass="16273" checksum="C1BBE3EF839E4B0F" modified="2025-10-08" version="1">MAATDATLRAFFQSPKFAVVGASTNPEKFGFKVFRWYITHSLPVIPINPTAASIPVDGKEYPAVSSLSALDNPADTSVSIITPPHVTRKTLEEAKGLGIQAVFLQPGTFDDTVLEYARANFQIVVAGDGGHGREGWCVLVDGERGLREAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNU3</accession>
    <name>A0ABR3VNU3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="645"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="843" mass="95611" checksum="905728A02E61AE88" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP34</accession>
    <name>A0ABR3VP34_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="330" mass="35960" checksum="C41D6D2EF155E414" modified="2025-10-08" version="1">MASVFSDSERRFILAEMIKLSQLDVGILVDFVKAHQIEPNWMHMQLPVGRNMDQCVRATEAMFGMTMQPPIISPLKRKSLEEPPEFAAAKRQAVLSPSEPSPRALPQGSGNPLGPPPALGPPPATIHPRPNGSSPTPSAPMASVSYVTSTPYNPAPTRRPRGRPPKHAQQHWQVSTYHPIAPSTASSQPHSPGVQTQTQSPRQLSAPALPDPTPKRETLPKIAPRPSAGAPASAEPATQSPSLPGADYQRWRDETMRRDYYQAQPADHTQRDRPQYPPILPRPQSPYPPPRDMPRTQSAEPRRYTATPPAGASGSSRKASQDASSEQNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPI9</accession>
    <name>A0ABR3VPI9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="1171"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1541" mass="171804" checksum="2D152EFE24A2E8ED" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPU8</accession>
    <name>A0ABR3VPU8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045713503" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="68111" checksum="4B629D4D7A89A77F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ90</accession>
    <name>A0ABR3VQ90_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein NO VEIN C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59729" checksum="F8183D5D02E46498" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQE4</accession>
    <name>A0ABR3VQE4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1844139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="95" mass="10542" checksum="26C2033F35CB558E" modified="2025-10-08" version="1">MRSSTSFSGTSLSPRVVSFPTSTRTCCPRRPARLARTCLRSFKFCLELFFSVFLVGKLGSRFRGHGFSGHSVFSASGLYINSMMGMVMVMNENIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQQ2</accession>
    <name>A0ABR3VQQ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_4939</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="211"/>
            <end position="252"/>
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            <begin position="255"/>
            <end position="296"/>
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        <location>
            <begin position="350"/>
            <end position="594"/>
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        <location>
            <begin position="622"/>
            <end position="777"/>
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            <begin position="854"/>
            <end position="1202"/>
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            <begin position="845"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF04053"/>
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            <dbReference type="Pfam" id="PF06957"/>
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        <source>
            <dbReference type="Pfam" id="PF23953"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1844087.1"/>
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    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Transcription regulator Rua1 C-terminal domain-containing protein</fullName>
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        <name type="common">Soft-rot fungus</name>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <end position="558"/>
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            <end position="127"/>
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            <end position="279"/>
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            <end position="107"/>
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            <end position="258"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Otillar R."/>
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                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Clum A."/>
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                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">CBS 620.91</strain>
        </source>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844038.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="371"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="477"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="114"/>
            <end position="141"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="741" mass="80015" checksum="8789A911E37E7F72" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0W9</accession>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">VTJ49DRAFT_6706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000664">
        <property type="protein sequence ID" value="KAL1835440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="355" mass="38955" checksum="A78FB67E4960BCAE" modified="2025-10-08" version="1">MDQIEQWFPPGTDPDVIQEAISKYYYSCTEVTPTCPVERTTLGYYPNRGINIFFAIGYFAALVTALVLGLRTKTWSYTAFVAAGCALEVAGYSARIPLSDNPWNKHAFETQIVAIILAPTLVCISIYLTLKHVCLALNPTLSRIRPHLYPFIFLPLDVSCLLLQAIGGALAASAALTNLRMVQHGNRCIIAGIVLQVVVLGFFGTTAGDYFVRLKKWIKSDQADPEAVELWKSKKFRMFVYAVAGAYSGILIRCIYRIAEMAGGWGNHIMQDEPSFIVLEGFMVLIPCILLATFAPGYLFPQMAARMSAHKGKGTRDGEEKQTVSPSAESEKSGLQHHTTTSGDEASPVQGDVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V141</accession>
    <name>A0ABR3V141_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000633">
        <property type="protein sequence ID" value="KAL1835500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046893392" evidence="2">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="282" mass="29242" checksum="076024610330178A" modified="2025-10-08" version="1">MKIHVAALAAGLAGCIWCLPPGPQRRQDSNLAQTSALAVVAPASTSLVAFTAQQTPVAFQATLVGKRGDAGSAKVDKAVPNKAAPKKASSKKGASKRSAKVGKGGKFGKVGKPYGYGKPYGYGKPYDNDDTSDDSNDTYRARWRRQERGDGCKRGGGDGCNGGFDSRGNGNGNCNGNDGFDGNCKRGDGDCKAKVQPQEPPTDNDGFDTPTDNDGFDTPTDNDGYDTPTPPPSAPTPTPTSVVAQAAVVVDQDGSLAVQQKDGKVVRKALGGFLYHGEADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1N7</accession>
    <name>A0ABR3V1N7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000564">
        <property type="protein sequence ID" value="KAL1835693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="238" mass="26882" checksum="218353DE8A4E09BA" modified="2025-10-08" version="1">MTSDDRARQSAHVEQPVQISATSATTTTTISHHPTAAVALSAWSQQEQKQPIIFLLAEDVAAITADGEPLRQPHPRLRRHHDGTRSRLSAASGATDAATTAHTALVPHPSHYSRARSGDGKEEGEDGPEEYTVYPNGRIVEESSERERRHRRGGERHDRSSYYYHGDRRKHPYQKGREWCPQDSDCDYSDVYYGSEKDRDLERRRKRRRSRDQAKGLIVAALVLVAGVVLCWDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1V1</accession>
    <name>A0ABR3V1V1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000542">
        <property type="protein sequence ID" value="KAL1835760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="TMEM86B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
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                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 620.91</strain>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="66508" checksum="08A9981ABBB3B9BC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V239_HUMIN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAZGSY010000533">
        <property type="protein sequence ID" value="KAL1835807.1"/>
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    </dbReference>
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        <location>
            <begin position="350"/>
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            <dbReference type="EMBL" id="KAL1835807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="384" mass="43604" checksum="29F348F746A0C4A8" modified="2025-10-08" version="1">MSTIDELISYGSGEIVLAGLWVVPLSVLWFISLCVARRKRDPARTGIAWLKAAYPFFILSLFLWTIAGGLRLWYWLDDYSWGSSFMENLNRATRHVSGVSSFLRNIGDILLFITFVELAIGFMICLKGNAEQSSAPKTGRIIILVWSFILFVISIAYLGVSQDNTSKTKSSYSSRDPDLPWALQQWVMLNRLYGALLILLWLTSLPMVVLSSVVMHRVRANYQLKRLASLFLVATILNALRLTILTAIDIHYYLTDVEGAVYYGVDVPLAVTFIVQPFFNHVFLFVLLVLLFVLAVRKRNGLWSQPQPEWNYPSVVYVPQQYAVGVVPVQAVPVQQVQPGTQPYPPQQQPPQQAYPQQQQPNTALPAYLQYAQQQQQQQQQQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2L0</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000481">
        <property type="protein sequence ID" value="KAL1836018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="151" mass="17489" checksum="45C5667310AD9007" modified="2025-10-08" version="1">MRDDERVESSRRVSQKERRRRKASSRWRARGRVERLGGGKPRRGLTTLRVEICVVARMQGLWQQLVCSLQRPNVWISQFGDAMVWGGGPIPRRLVSCVALGTVWMQWRCSCRGRVQVDETDSSLLSSLFWLMRVARRWAVVHLPGCVEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2V8</accession>
    <name>A0ABR3V2V8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="11" type="ORF">VTJ49DRAFT_5568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000464">
        <property type="protein sequence ID" value="KAL1836108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="597"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="558"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="396"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="455"/>
            <end position="456"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="699" mass="77975" checksum="80F70DD4BBE06F39" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V349</accession>
    <name>A0ABR3V349_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="JAZGSY010000454">
        <property type="protein sequence ID" value="KAL1836167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="653" mass="74609" checksum="0CB8468B15F6D345" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V393</accession>
    <name>A0ABR3V393_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VTJ49DRAFT_5603</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="JAZGSY010000468">
        <property type="protein sequence ID" value="KAL1836080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047484819" description="Crh-like protein" evidence="18">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL1836080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="377" mass="40113" checksum="CDED71E875E1A96B" modified="2025-10-08" version="1">MLFKIFKSVALAATLVSAQTFTECDPTKRDDCPNPKAVGAKVVDIDFRKGPSSFFKLADGTSLKYDANLGAVFSISNENEAPTIASTKYIFFGQVDVVVRASAGAGIVSSFVLQSDDLDEIDWEWLGGDNTQVQHNYFSKGCTENYDRGGTSGVGDPIGTFHTYTIRWTPEKLEWIIDGTVVRTLQNHAGLTGCDGYPQTPMQIKLGNWVAGRPGAPQGTIDWAGGLADFSKGPYEGYYQSIRIQDFMGGRGAKDATEYQWTDRSGTWESVKVVYNGEEVDQDDVTTTKKTSSTSTSTAKSSATVTSSFATVTKAVSTASFPTTPGSSFATFDPTSTESEATATETGEPPLATAAAPRAGVNMAAVAVAAVLGYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V395</accession>
    <name>A0ABR3V395_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000443">
        <property type="protein sequence ID" value="KAL1836235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="160"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="338" mass="38474" checksum="586A1AD060D222DA" modified="2025-10-08" version="1">MDFSFMDEVLGLDEEEEDDDDEVPWELPDGRLVCGPHGLVVCGKCCMDFSFMDEVLGLDEEEEDDDDEVPWELPDGRLVCRPHRLVVCEKCSMDFSFMNKEEDDDSEDEIDLELRVGTGQAFPVKFVPTSSRSPDELFSGRKHEKQVQGRYILRYTLPYDDGTVLIRTDGCCLENGQADPRAAWGFWHGARADASETHLTGKYRLEKKGPWGHDAPQTSNRAELRAVIAALRCHFWPSKGFHTVVIATDSEYVVEGSTAWVKKWVKNGWKTSSKEPVKNKDLWEVLLGEVEKYDERGVAIEFWRIPREWNTVADAAAKEAAAEDYVPGMWTECCIANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3C8</accession>
    <name>A0ABR3V3C8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000440">
        <property type="protein sequence ID" value="KAL1836257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="240" mass="27421" checksum="83433D9616AE42FC" modified="2025-10-08" version="1">MTSSVDPHTKVYSHLNGTVGELLDRLAVAELCKGWAVYRDSSEWNNYRSLFTDDATVWTIDRFISLSKAGKENGVFIMHRECGTLVELNPATRRAIGKMKATITHRFQFNPTTSTLDPDQSRNTAEFDVDCDCRFIFFCEKSPETGHWKAKYVKLFYEKDKVVPVDGITAPTFTDEELASIPRGYKYLGAAQARLGYRVDVDLPTAGGKLFERMYGEMEKWLDGQEVDLFWEKVEKKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3E1</accession>
    <name>A0ABR3V3E1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000435">
        <property type="protein sequence ID" value="KAL1836292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="221" mass="24001" checksum="AB3EDCF67EADF3AF" modified="2025-10-08" version="1">MHSKRHRPDRIKPDPTPTTSSTPPSELSIPARTSSTNCRHWTDLHISRMTSAMNTDIPDGPKPPKPPTPPKPPKRPSLSSVPPIPKIPLRSSARKPRAPNPQVDGSDHDDDYAPYLEALQRPSAAHLRPDLRLPLGRSVSAGLAPPLATEGVNVDSDFVRIQVPPPARLPPPPPLPPPSELEPAATTTTTTSPIQQANHKQPNHPRTTCPPWIEPEPSQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3F9</accession>
    <name>A0ABR3V3F9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000507">
        <property type="protein sequence ID" value="KAL1835921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="18"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="757"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="898"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="920"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1159" mass="125067" checksum="BE393620F15A5081" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3L7</accession>
    <name>A0ABR3V3L7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000449">
        <property type="protein sequence ID" value="KAL1836192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047168752" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="449" mass="47981" checksum="BC60C87EF20C5F62" modified="2025-10-08" version="1">MFSATLLLAVACVSALTHEDIARFPDADFGGAFETADTPDCKTFPGDPAWPSDKEWSQFNETLDGALLHPPPPASWPQGDTCPLTEDPVGICTRGGYPVYVVNATSVKHVQAAVNFARNRNIRLVIKFVLPSGAGSLSVWTHNLVGFQFLPSYTQPGGNYQGPAVCMGAGVQAAEALAYAERTNITLLAPNPGSGCLSVGTSGGFFMGGGHSPLTSKFGLGADQVLSIKLVTADGRYITADPQTNPDLFFALRGGGGGTYGIVTSVIVKAHPPVNVTFARFNLTLSSTTSTAPGPDVTVADAETFWRGVNEVLAFSIPTVDARGYLWALTIPLWSNQYQMQVNVQMPNRTPDKLVAFLQPLLDTLNEARIPVTIDTPMTTLYTSLTQGGQIDDWFFNTRLFPRRVFEDEGLFDDATTAIRAAVEARLAFLSLSMSPTLRQASTPPGAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3U9</accession>
    <name>A0ABR3V3U9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000412">
        <property type="protein sequence ID" value="KAL1836430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="259"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="564"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="641" mass="72031" checksum="8B824B3F20F56228" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4H0</accession>
    <name>A0ABR3V4H0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature viability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000383">
        <property type="protein sequence ID" value="KAL1836655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48335" checksum="EF2DF70EDD7C0469" modified="2025-10-08" version="1">MAKGKKGKWIDKKTATHFQLVYRPQNDPLIHDENAPQMVLNPTQPANRKGRNLSELASQLGSDALSIRDNEGEAANYGIYFDDTEYDYMQHLRELGTGSGEAVFIESTASGNATRKKANKGQSLEEALRQLDLKNQSEDLLDESILPNKNLQRLSYQAQQDVPDAIAGFQPDMDPRLREVLEALEDDAYVDDEGGEDIFEELAKDARELSHDEFEESSDDFFEEEEGEDAGYESDRTVKASGEQQQQQEQKQDSKDAGPAGDEQQPPPTAEAASGDWMEEFKKFQSDQKKAAGNKKPGRAAPSEMQASIWTTTTNGGRRKVRKGALTNPSAYSMTSSSLVRTEQMSILDARFEKLEEAYLEDGDELGSVSAVSNMSTVQGPTRQDFNNLLDEFLDDYSMCGKKRVKKGKGRGGVSEFDEIRKALGPPIVPAKYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4V2</accession>
    <name>A0ABR3V4V2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000365">
        <property type="protein sequence ID" value="KAL1836794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="273" mass="30259" checksum="39AB3AC8B4598019" modified="2025-10-08" version="1">MRTVLVPRDSTVSGDDGRTHENLGPLLDGVFWTLTTFALVFLALRLYCKFSRGRSLWWDDHFLIAAWLSLAVSAATTSVCVSLDYGKNVWDMDPKNLPKMPFIAVFAGFFSVLAAAWSKTSFGLTLVRICHGWIRALVWFIILTVNAILGTAMLTMWIKCRPVEKIWDNSVEGWCMDPHKIVVLYQWSAGWSGCADVILAMVPWSLILGMRKTLNIKERVGVAVAMSMGIVAGVASFVKMAMLPNLTGSAGMFFFPFASFPSVPNFVQSTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4X6</accession>
    <name>A0ABR3V4X6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000362">
        <property type="protein sequence ID" value="KAL1836818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="223" mass="25502" checksum="E661C0ECF4BA897F" modified="2025-10-08" version="1">MAQKAVNQDSPPHGEAQGSGEINNAINNQFKNFIALPTELRVKIFEMALCKPYPLYPEFFEHWVPSDNCRPCGPYTVGLLRMSRQVAVESTQLFYGGNTFNFVSIKVAKTPSKEFVHEGSSIILWLREIGLNAAFVQNIDYRFYPTDDVDVDAAKFEIGHLHHLVPGLRRLTIFYNPNHIAEAFFLSKRRHPDYEGKCLFDHARGVILGEFSDLEELRIVQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5P4</accession>
    <name>A0ABR3V5P4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000368">
        <property type="protein sequence ID" value="KAL1836771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="436"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="629" mass="69505" checksum="281518C7052B7CE8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5V4</accession>
    <name>A0ABR3V5V4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000376">
        <property type="protein sequence ID" value="KAL1836703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="213" mass="23174" checksum="6E10DA92BAF1827C" modified="2025-10-08" version="1">MLQSIMSSETRKKAWRSSVSQPRVAAWKYSSSVRGRPRSTEAESTTDMPRLHLPPTTLNSRDCRGTQETGGQQVVGRWPCAGSAIYLGNQGPSDTGSRNIKNNINTPSCTSHRLVEGGCRSGPARGGPPGVWGRRPRTPEALSFGPCLRCGVSVVRDETREGFEMVQIQVNRTKCGLGGNPFCTDSLGGTRRGDNLEGVEQREQREPDNGTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V610</accession>
    <name>A0ABR3V610_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000318">
        <property type="protein sequence ID" value="KAL1837203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="89"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="474" mass="53090" checksum="CD9EC4EAD8764D1B" modified="2025-10-08" version="1">MAFNNTAGDWAGPNSTFTGDSAFTGNSTFGWNATFGEFGGNGTFSGNGTDFNATFPYWPIPEYPSRSLQADIVACAVITFLIAATFVGLRFYTRGYVSHILGWSDWLILPALLCSAGVTASAIEQMVHGAGKHWWEFDIFKFGDFERAAWYGMLFYNISLSFSRISILLLYKRIFTYDWIKRAIQIILVIVVALSIWFVISVCTVCIPLEAFWDWSLYWTTYVYCQPANLWWANAALHIASDVIIIALPMPVLSSLTLPRRQKYAVIGVFALGFFACAISIVRLSYLVMATQQDWQTVDGSYRSAYMIFWTTVEVNAAISCACIMTLKPLIERVFPRLLSPDLDNRDPSLHWITPIRNESVYETENDNNNTNNLDKRASSCSPTSPSFHLTSLTPTPHPPSSAYYPRRTSAPALFPVRSRTGSIGGAGLPNLPEHRPDEHDDALEKSRYYHGFTAPTAVPGRKCQRQGKPLRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V681</accession>
    <name>A0ABR3V681_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000332">
        <property type="protein sequence ID" value="KAL1837077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="418" mass="48763" checksum="F981D2BDEF312B74" modified="2025-10-08" version="1">MSDADEVVTDAGPLDEPSATHPPASSIQKDEDDYDVYDSLDWDSLKAAGAEEHVIAVFERAFARPDTSDPNSGWTQDDEDRLMARWRTHPLRKAIQERCRDLTESSPEVRLWRQAIWYCHCLPTEVISIKDGMIPEYETNPQVKKLRRTVPWPGHPQELLWSPAFCGALAEVMTYPDLSFSEELRATIQYVVISATDDRRPWDPDFDPQDEFLERFWAMTSQNDYIPLKELRAALQRVMLKEDPNKHVWWGRFFGFVESVTAEERKVNIRAAWVTGDRMDPDMPIVVRLRDLGYLIDAYKLECDGDCTRLDFQDMFGPSFLTPRMYQLFLEATWLDVWREQERGACPRMAIIIRDKYFDWRTKCAEKPESTESTHQVESEQTAGTDGDSTLDKVHKWLAGWDGGWMWWDYDDDDDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V683</accession>
    <name>A0ABR3V683_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000311">
        <property type="protein sequence ID" value="KAL1837278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="59"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="473" mass="52443" checksum="7CF00FBBED3548BF" modified="2025-10-08" version="1">MASSGQDPTAMGGAPGALPGGPPPGLPPGLVSNPNESRQTNIIAAAVTCWAISVVFVSLRFYSRVSLMRNPVIAEDWLVVVSLVFAGAMSGTFIAQAKYGFGRHLLDTSPANYKPMKMSFRLSSWNYGFHDALTDNYLLAAPQTEWLGMVWYVASLVIIKVSICLLYLRILRFRHARYVIWGLLAAVVIFALYGLYGIFTACRPLHLYWTYPPNSTGACRPKQDWIINTSFHIATDVIMYILPLPLVLRMRAPGGQKMVLYAILALGLFVCVVSIVRLWDFDRALSSVDVTWEAASIAYWSLVETNATIIVACVMTLRPVIKRWFPRFWGSWTEPSGGRQQQNYQPGQGGGPARGTNGDPEHGGRELVTFGSAPSRAKRSRGGRHGLSDSTLRTIDDVDGPLVPHPATTCLYTTTTTTITATNSQEYNDKTADTDGESSLEEQRQRVEQHRQQLQRQRNQAWSPREPPPVHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V693</accession>
    <name>A0ABR3V693_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000312">
        <property type="protein sequence ID" value="KAL1837270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="185" mass="20649" checksum="5479929AD1E1C8D4" modified="2025-10-08" version="1">MAPEPTQRRTAEEMDITLHSPDSTWPRSTCTTVLPAVNAFSLANAFLGQLITYVVGGNRTVVSTIAGVYRSCGPSTVPQILRYLSVDTELREHLVKDLTDWVRGIRRPSSPTLTTRLTGPGASSNVPSKYEEKERMLNSESVQNSQSDVSSKYGRTYDRGDITWLNLEGRGMVQDTWFHQQDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6E0</accession>
    <name>A0ABR3V6E0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000306">
        <property type="protein sequence ID" value="KAL1837324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="313" mass="32290" checksum="157141D3558106BE" modified="2025-10-08" version="1">MSYPEPPHYSNGVDLGLSPEPYNAYPRTSHEYAPPPPMAYAGEAPYMYSSHSNSGRASPGMYPDDGEASASSSNMGSPLSAHGQMPATTISDWSSVAAPHGGLGVSPGIVDQSDYFPGDYSLAPPMDHYSPSYEFPAPSKGPGFVGESSQIPRSSSLQSSSIPVSSSSPRPSSGSGRESGHAHAHCGPVSSTSSRESRSTTTVPPKSSCPGLALDTRLARQQPLAATTTSVSSSTVSSGSSSSFSSVAAAPLAMTPPTSAAASPSSLAAWGSPPGSRFVSPFFSQSSGHFVPPLQSCWFFLLFCSRGELRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6S7</accession>
    <name>A0ABR3V6S7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="8" type="ORF">VTJ49DRAFT_3797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000296">
        <property type="protein sequence ID" value="KAL1837426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="278" mass="31866" checksum="5AE801E29FC62CBB" modified="2025-10-08" version="1">MEVTLKRTAALIARNPLPQHAAAALTTAQNRRPFSFSSLTRPPPNYPGHVPLSAIERAALAIGSDLIAIFSEVTATPYFIYRLRDAMLSSPTGRRILRDQPRITSTSLNLPRLRSLPEGTVGRTYVAWLDREGVSPDTRAPVRHVDDEECAYVLQRYRECHDFYHALTGLPIVREGEVALKAFEFANTLLPMTGLSVFAAATLKQSEKRRFREIYLPWALRNGLRAKEVINVYWEEELERDVEELRRELGVEPPPDLREIRRREREERRRRKEAAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7A4</accession>
    <name>A0ABR3V7A4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000273">
        <property type="protein sequence ID" value="KAL1837674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046224387" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="39410" checksum="68B044CB2DB5F72B" modified="2025-10-08" version="1">MTTTKRGPSARLRAMLLPLLAVCLLPRGVEGQDASKKPIFVYPPDGSNFIWNKMDTVLVTYESFYDKADFWIFCEPGKGKYISRQAAPGWKATVPVVLNFTSDTPCWFNVRTGENGIDGANSATFNVIGQVRKDGPTVHGLDITSSSSSTSSSSSTSTTSQEGRPTTTDASTPTTTDDSTEPTPTDKENGNRDDDDSDPTPTRGSSSPNTTSTSASDTETPEVAAPGGGLSAAASAGIGIGAAVVILAVGGGLFLLWWRRRNRSEPGQPAEMEGDSVPPYDGVYRGYGNGGGGGGSAYDGSAGLGGYHNHNPPSFGALTPDEHLTRKNQWGDGGPPPQQQPAVGELSAVEEVVEIQDPASFVGPRAWTRHYEMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7B6</accession>
    <name>A0ABR3V7B6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial genome maintenance protein Mgr2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000343">
        <property type="protein sequence ID" value="KAL1836973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12287" checksum="5F485CA61E35EEF9" modified="2025-10-08" version="1">MPPPPSHPGAVGPSNFDKWKMGLLMGGTVGTIIGFIFGSVNIFRYGAGPNGIMRTLGQYMLGSGATFGFFMSIGSVIRSDASPIVQEAYFRAQRRPIIMASQAFRPYQRPPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7K4</accession>
    <name>A0ABR3V7K4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000266">
        <property type="protein sequence ID" value="KAL1837739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="340" mass="36726" checksum="4A76E910FA44B60F" modified="2025-10-08" version="1">MNGRLELALHFFKGQFRSMPLPTTSYAGRTVIVTGATGGLGLEAARHFTRLGTARLILACRDSERAEAARSDIQKSLPDSSTTIEVWPLDLASFESVRTFCHRAEKELDRLDVLLANAALLAIDKPKMAEGYELQITVNVISNTLLILMLLPLLKRTAATHNVEPVVTLVSSLGHILTTFTQHSSPHIFSTFQPGDHMTERYATSKLLGILIIRELAERLNAAHHPSHPSPVVVNTANPGMCKSDLFRNLPAAGRVVVGALNQLLGRSSDQGARALMAAVAAGRESHGKYVDSARIVEPGSFVRSETGGMVQKKVWGELMEILDGVEPGVSGNVERALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7T0</accession>
    <name>A0ABR3V7T0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bladder cancer-related BC10-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000272">
        <property type="protein sequence ID" value="KAL1837685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17045" checksum="1C3CAA0CBADD7451" modified="2025-10-08" version="1">MFCLRSWLPLLFIPTNASPSFIFLFFLCTYFLNRPCFYCSFLLLILFLTSCNWSDRCFLDLSGNWFESNTSQQLEGHKGQNASGGTEDLNATASAVAIEMLNATAGALATAAKNHLTQTTSEWTGLGLEWLRSLLGRREWRIDCLDVNIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8M3</accession>
    <name>A0ABR3V8M3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000296">
        <property type="protein sequence ID" value="KAL1837423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="100" mass="11622" checksum="ED8685679A0069F9" modified="2025-10-08" version="1">MDPKKLSICANYYVRAPLTRKDAWLRNADMYMFTFPHPSDLDPVCKHGPHVWQSLYALPALEEKKQEYRPRQRQHQREPQTALVVAVNVHATMLAGKHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8N4</accession>
    <name>A0ABR3V8N4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_2972</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 18"/>
    <dbReference type="EMBL" id="JAZGSY010000233">
        <property type="protein sequence ID" value="KAL1838170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="20">
        <location>
            <begin position="112"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="436"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1838170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="525" mass="59630" checksum="03C6AF8019653E71" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V918</accession>
    <name>A0ABR3V918_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000280">
        <property type="protein sequence ID" value="KAL1837588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34321" checksum="11A882904F128AC5" modified="2025-10-08" version="1">MAAPSSAPVAATSSGSLPTFTGTEGAYMLPHHRKEIERLHRQHEFMNTTTGGQLLLPRIIPQQRSLRVLDSGAADGFWLRDLPRQLPSKDLALFGVDIGSSLFPAPGEAAASGQQADLRSHDIRTPFPESWGWTNTFDVVHQRLLIWGIKASEWPVVISNLISVLKPGGYIQLVEAEWIDPANPASEVTRPELAKQAALQKWSTASFGMDIDIAYKLEKLLSDAGLEDVGVVQFDHGYGALAKAESQKNVSAELWVDCFRTLDEKIPTGGIPGVAAYAREFHEFLDRLEVEIKTYGYQPKLNFVYGRKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAI9</accession>
    <name>A0ABR3VAI9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="6">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000202">
        <property type="protein sequence ID" value="KAL1838645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="7">
        <location>
            <begin position="73"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="7">
        <location>
            <begin position="557"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="875"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1063" mass="115864" checksum="73DA17FB42EE9420" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAJ8</accession>
    <name>A0ABR3VAJ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000190">
        <property type="protein sequence ID" value="KAL1838853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046932892" description="TM7S3/TM198-like domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="137"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="785"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="907"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1012" mass="106183" checksum="F313928E5958A8E4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAM1</accession>
    <name>A0ABR3VAM1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000215">
        <property type="protein sequence ID" value="KAL1838426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="700"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="833" mass="91633" checksum="F56C4602DEE7164D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBE1</accession>
    <name>A0ABR3VBE1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000172">
        <property type="protein sequence ID" value="KAL1839159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="59"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="312" mass="34380" checksum="351E2A0C3CA14FC6" modified="2025-10-08" version="1">MSNPNPFEEYAKKVRAMANQAQRRGGFRPGGFPGGAPRLGGGLAGLLLLGGGALLFQNALFNVDGGHRAIKYRRISGISKDIYGEGTHLVIPWFETPIIYDVRAKPRNVSSLTGTKDLQMVNITCRVLSRPDIQALPQIYRTLGMDYDERVLPSIVNEVLKSVVAQFNASQLITQREMVARLVRENLSRRAARFNILLDDVSLTHLAFSPEFTAAVEAKQVAQQEAQRAAFIVDKARQEKQAMVVKAQGEARSAELIGEAIKKNKAYVELKKLENARAIAQLLQEAGGKNRLLLDAEGLGLNVFEDANKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBF2</accession>
    <name>A0ABR3VBF2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000173">
        <property type="protein sequence ID" value="KAL1839135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33311" checksum="B905308011BF48E2" modified="2025-10-08" version="1">MATTNEKAVCDLCADDFDPDKGLRGICREGHDWCAECLTNAVRTAAHHFSDTSCMPPRCCGDPILMLEPPKAADNRSVNGSTNATLSLLSPELRAAWETARRKAHALRSEGDPLDIDPTVVRMAMRYRGPNLYQFCKKCKRLTSRSNGCNHMTCICGHDFCLICGGDWFVPGSTEVSTQCHQVYGDSRNHVLKIPPEIQERIKLKDLGIPAAYLDEDATGILCHHEAHLLYKLRLRREPLRDGIPLKAQCHLCGRCFGEFLLECTGCQTLMCLKCRDYLWATRVREGTVTPEKARANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBP0</accession>
    <name>A0ABR3VBP0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000167">
        <property type="protein sequence ID" value="KAL1839258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="323" mass="36448" checksum="A96D58BF037FD190" modified="2025-10-08" version="1">MVTSSRSTSNGQTEIDSAVLAVLPPVQEVLDLTELTGSRWARLTRIHISPGPHGLAALQGEHTATTAIHTLTPSFCPRPIAVGTLHSSPTSHFYLCEWHDFLPADSPLPPPAPFCAQLARVHHSATSPNGKFGFPCTTYNGDLPQDNRWCDTWEELFVQQLRGVLAIREERAGGKDGELERLLPALFGRVIPRLLRPMETKGRRVRPALVHGDLWCGNVGVVVEGGDEAGMVFDPAGFWGHHEYEFGNWRPARNRFDERYFEEYHRLVEKSEPKEDYEDRNMLYGVRFNLNAAALFPENKEFLDMAIEDIRRLVDKYPEGYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBU6</accession>
    <name>A0ABR3VBU6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000164">
        <property type="protein sequence ID" value="KAL1839318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="751"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="848"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="946"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="964"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1040" mass="111079" checksum="538D01B69F8B26F3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC22</accession>
    <name>A0ABR3VC22_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-binding protein ypt2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13272" checksum="4DFC20E892B170D2" modified="2025-10-08" version="1">MGILLVYDVTDERSFNNIRTWFANVEQHASEGVNKILIGNKCDWEEKRVVSTEQGQALADELGIPFLEVSAKTNTNIDKAFYSLAADIKKRLMDSAKTEKEGTGTAVNVADQGGAGGGSKCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCD8</accession>
    <name>A0ABR3VCD8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000190">
        <property type="protein sequence ID" value="KAL1838848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="65871" checksum="563F57D3F45ED464" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDF6</accession>
    <name>A0ABR3VDF6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000151">
        <property type="protein sequence ID" value="KAL1839552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="541" mass="60968" checksum="CD67BADB3ABF7171" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDU1</accession>
    <name>A0ABR3VDU1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="158" mass="17085" checksum="186D6CB04CF50904" modified="2025-10-08" version="1">MEESARGKRRKEEEARRVVAARILISARGSLSCRFREDGPLLQNGKRVTPRGAKNGAGCRTQALCPNHTVLGLGWRGMAAAASRLLRRCTKGPAGRKTAWPITLGPSSSCCEKHEIASRRFGTGTQAFPGSRLRCNHQCSFGPTEAAALRQACLWGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEY6</accession>
    <name>A0ABR3VEY6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="8">
        <location>
            <begin position="558"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="792" mass="85882" checksum="B33AE434668D0E0C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF56</accession>
    <name>A0ABR3VF56_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52698" checksum="5776E51F7DB26874" modified="2025-10-08" version="1">MAVFVDLGEDESDIQQQGAQPLRNGNLDAVMAAGIELLSDGNLGLGLPGQRPAANRLDDTNPNSDPDADADADGVPVRENPNRNAMTQALGCYPIIMSVASSIDLNTLDSLSRTCRQIRQSLLQYRKMLLVSTLHCVNEDMPVDPDETLRYRARAGNWYYMQDVARSAYTGKSGRCARDLVAECRRCGVVVCRNCAIKPPAPIVLRDRHRRLCDPCVTAPLGSLVRPPLGPEVRIDSELMERAMCTCDSSGVWLCQPCGRSIRSDDGEYKGIWRWRNQYTVLGGLGTGIGEGDRGVICGRGSGCCAAREREQEMDGDAVDAREAEELHYQQAAAAAAATTTPGGGASTGSSSSASSSLASLPLFAITAPTTTTTNGNTTAGLGTLFDQHQHRTPSPALKPGYDRYEVEGIGGVVKKLHVRMVKVGACVPEWEDERVRGDVLGRELQGRRRSWCGWCQRVIPSRKDYEVDRQKWAGERQEEVKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF75</accession>
    <name>A0ABR3VF75_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000128">
        <property type="protein sequence ID" value="KAL1840071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="98" mass="10668" checksum="0D529EF2E8746FEB" modified="2025-10-08" version="1">MAGSYLARDGTSQDGTLVDIDQCELKAEHVTCATVADDIDIAFVSIGFDLVRIFVNGVRPRNGGAKSHCMLLPWSLSYFGTSRGFDFAAPLWPFRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFA6</accession>
    <name>A0ABR3VFA6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000114">
        <property type="protein sequence ID" value="KAL1840424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="761" mass="84229" checksum="DD4BB9CAFCFE9C15" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFV2</accession>
    <name>A0ABR3VFV2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="353"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="692" mass="75331" checksum="49EB270D94A39D41" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG69</accession>
    <name>A0ABR3VG69_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046067385" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="95" mass="10094" checksum="8ABF710F1BA94689" modified="2025-10-08" version="1">MRPIKYASAVLLAIGFGGADAATAQIYTTSARVDGIAKVGLCKDINGNNCSILGGPKATCLNLPSGWNDAITGIDMIAHHGCRFFQYVVRFHRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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        <location>
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            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="288"/>
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        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="456"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="543" mass="60453" checksum="85F793C02F557DFF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGW3</accession>
    <name>A0ABR3VGW3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7426</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="5"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="947"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2449"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="947"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2406"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2417"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="979"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2534" mass="275401" checksum="279586C96A67CDFB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHE5</accession>
    <name>A0ABR3VHE5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="188" mass="20868" checksum="A282859AC6095343" modified="2025-10-08" version="1">MSSSQQHREPDPTENAVPDTELGLTEDQLQLLRHGQQAVAAAAPGSTSSRAASRASSQGLLLMDSSSLTALGHHFDRVMQSIQQRLEYLMEQSQIVTLSVYDHAGNLIDNADAEIARYHDIMAQIDELELDFDRIAGIRDIVRGFRQRAEELERELERSGGGSSSRRERHGHSSRRSHGHSSGSGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHP1</accession>
    <name>A0ABR3VHP1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="291"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="653" mass="71554" checksum="03CBB6AB736CE8C8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHR1</accession>
    <name>A0ABR3VHR1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045364078" evidence="2">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="255" mass="27940" checksum="C4472A26AEE912BF" modified="2025-10-08" version="1">MARAAFFRLTLPVILCGCIYQTLTAPIPPPVDDDGAHPYLVPGPDSIPTPDAVPTDEAEDVDIIDDLSRTASWLQDPKLLDGLRKLLDIIDSHTERMRDGGCGGCGGGGRVNTAANNTANALTGGGVEEEEEGIEYTNPNCDPDPLDLLQGLPPRPRPQPPQNEVQVSSDDRGSIHITCKGISVCNPVTVVHSKDGKSISLDALGSSDGRSWWRGRRRKKKKEKDRGKVGGSRWRSALRKWKWWFSSFEDESWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHS4</accession>
    <name>A0ABR3VHS4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_7107</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000077">
        <property type="protein sequence ID" value="KAL1841377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
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    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
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        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="713"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1142"/>
            <end position="1260"/>
        </location>
    </feature>
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        <location>
            <begin position="1512"/>
            <end position="1626"/>
        </location>
    </feature>
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            <begin position="289"/>
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        </location>
    </feature>
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            <begin position="362"/>
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        </location>
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        <location>
            <begin position="501"/>
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    </feature>
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            <begin position="875"/>
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        </location>
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        <location>
            <begin position="998"/>
            <end position="1020"/>
        </location>
    </feature>
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            <begin position="1182"/>
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            <begin position="1275"/>
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            <begin position="1404"/>
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            <begin position="1659"/>
            <end position="1693"/>
        </location>
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        <location>
            <begin position="1717"/>
            <end position="1905"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1920"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1973"/>
            <end position="2050"/>
        </location>
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        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
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            <begin position="365"/>
            <end position="381"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="516"/>
            <end position="525"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
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            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="888"/>
            <end position="901"/>
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    </feature>
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            <begin position="906"/>
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        <location>
            <begin position="998"/>
            <end position="1007"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1300"/>
            <end position="1328"/>
        </location>
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            <begin position="1413"/>
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        </location>
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        <location>
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        <location>
            <begin position="1721"/>
            <end position="1734"/>
        </location>
    </feature>
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        <location>
            <begin position="1735"/>
            <end position="1754"/>
        </location>
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        <location>
            <begin position="1788"/>
            <end position="1806"/>
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        <location>
            <begin position="1841"/>
            <end position="1851"/>
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            <begin position="1852"/>
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        <location>
            <begin position="1870"/>
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        <location>
            <begin position="2004"/>
            <end position="2017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1841377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2050" mass="220516" checksum="0A78F08F34B27CA5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI35</accession>
    <name>A0ABR3VI35_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
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            <end position="206"/>
        </location>
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            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="384" mass="42008" checksum="3B7771FEE9B5E83C" modified="2025-10-08" version="1">MSAPAMPPPPSNPAENDGPRILGATLAVTTIAVLSSIARIYVRTSMIRNFGLDDFFMTFATLLVIVEQGIVIGSVHHGAGRHMGDIEPSDIMMGMKLNFISQILYLFGICFVKLAVGAMLLRIASVGFYKRLIIGVMIFMSVYTVGCFFTLVFQCTDIRAMWDPVVQAQATCWTPQTLQALSYTNVAFNIFTDLLFAVFIPVPMLWKLNVNTRTRISIMVTLGLGIFACAAAFIKMGYLFNYGINGDWLWDSRDLTIWAVTEVCVAMVGANLPSLRPLFKGVLGSTLGYGTATGKKSTTGYQRQHDATSRHNKSHLDETSSERAFNPACAYEMNCQSKQTKMSTVVFSDRTGLSSDDTVNASRGPATAQNGITMTTTTNIDYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI63</accession>
    <name>A0ABR3VI63_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="250"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="485"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="555" mass="61707" checksum="36E81AF9393506A4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI76</accession>
    <name>A0ABR3VI76_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="264" mass="29562" checksum="DD5D82D08D11964F" modified="2025-10-08" version="1">MPSRCVRVAAACWSSNNADERPTCWKLKHNTRKLAIVPTNLLHNNNNRRTQLPTQPQPKCMEVLLGITGKDFTLIAASKAAMRGPTILKATDDKTRQLNDHTLLAFSGEPGDTVQFAEYIQANSQLYSMRNETELSPSALAHFVRGELASSLRSRNPYSVNLLLGGVDPITNKPSLYWLDYLASLAKVPYAAHGYAQYYCLSLLDKHHHPNITLDEGMKLLRLCSDELKRRLPIDFKGLVVKAVTKDGIETKPFDEDEKVVKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VID2</accession>
    <name>A0ABR3VID2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045791576" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="177" mass="18823" checksum="A8CA36AED771B5D1" modified="2025-10-08" version="1">MHLINLAVLAAGLASVNAAAIHPLSDPDLVVLKTIDLGDATLYEVGRANSTTSTPVRSSSEEGSKLQARCGSNQVVCTSHDYSTYLACDGLIRSINQTPHNELDPAAIGLYRVDEYGTICYTAWPQRIPGLRYGHLVSAAWKVNSVCNGGARVSGYAHDVNLNGVCTRQCVNSSGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ47</accession>
    <name>A0ABR3VJ47_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="174" mass="18650" checksum="589E12976052536F" modified="2025-10-08" version="1">MAPAPDSSGPAGNPSLAPLETKETRLTHKSSDDSLSPQPFPALDEKNPHFTVSTPATTRANPFDADLEAGATVLPVYTQESSSSSTPNRKSAECTKGGSDCQVWPGQDHWRRKAKDARKDRRSCRCLAGMSKRNRILIRIAIILLIVGIAVAVGFGISKPLGAGIWRSETQNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ84</accession>
    <name>A0ABR3VJ84_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="97737" checksum="BA74F8A4C8B66520" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJH1</accession>
    <name>A0ABR3VJH1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11726" checksum="F6986B16756D9FE1" modified="2025-10-08" version="1">MVVKIRLARFGRTNKPFYNIVVAHARTARNSRPLEVLGTYDPIPKPDPYDPSGRLHKDIKLDITRAKYWIGVGAQPTDTVWRILSYVRAVPVPCVPLPTRHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJQ7</accession>
    <name>A0ABR3VJQ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_6114</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1842044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="468" mass="52772" checksum="A69542367179E67A" modified="2025-10-08" version="1">MWRDRTNLYVSYRQSYAHHPTQRNRYGPSRSGGDRFGGGSGASTGVLFSADDDRRGLLSSGAYDVDDGDAVIEMDLLPPRWADVSDEVTELLADIASKGQKLDRLHQKHVLPGFNDEETKKAEEGEIERLTQDITRGFHECHRRIQRIEQMVREGKANGQMSRAEETMAKNIKVNLATRVQEASAGFRKKQSAYLKKLRGMAGLASPLERSATPLGGTSYTDPSILESDADRTYSQSTLQAPSHQKLLNSNDALISQREREIEEIAQGIIELSDLFRDLQTMVIDQGTMLDRIDYNIERMATDVKEAAKELKVAEGYQKKTIKRKIIFLLLLIIAAMIILLIIKPKKHRDADGAPEPNRKHNADGCALDNSLLNPPNKVHQNQQFYQAAYRAHTRLWRINPRSKFYLRPYVVVLWGTTAGMRSPRLPPDESIFAAAGIARNIADHHDVLAAMYAMGRKVWGKNTWFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJV2</accession>
    <name>A0ABR3VJV2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_6461</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="208"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="541"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="247"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="847"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="898"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1086"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="898"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1086"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1116"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1841862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1131" mass="124725" checksum="7AEB19CE1B4B226C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKA5</accession>
    <name>A0ABR3VKA5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Malonyl-CoA:ACP transacylase (MAT) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_5492</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 15" id="KW-0520">NAD</keyword>
    <keyword evidence="5 15" id="KW-0521">NADP</keyword>
    <keyword evidence="6 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="16">
        <location>
            <begin position="1533"/>
            <end position="1846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1842324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1927" mass="211325" checksum="03B435E24C0EECCB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKC3</accession>
    <name>A0ABR3VKC3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="723"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="641"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="835" mass="90940" checksum="B2E0569D624C28B0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKN3</accession>
    <name>A0ABR3VKN3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000059">
        <property type="protein sequence ID" value="KAL1841923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="361" mass="40654" checksum="845AD62F8B009265" modified="2025-10-08" version="1">MNQALGGWWGCRRDDDVTNLSPPAAIRRQSTERRQKLPILPFQSSLSLSSTCRPATMATSSFSSLVLRLVTLNVRYATQRPGPNEKPWSVRCPRLCAQLKFIASGQDAPFLCLQEVLHSQLNDTQDSLGSSWAYIGHGRQDGKEAGEYSPIFYRQDLWECERHRTYWLSPTPDVPSKGWGAALERIVTVGLFRHRRTETAVVVMSTHFDHRGKVAREESARLLVKLAQTWAEESEGGVIIPVFLGGDFNCPPDERAYKILTEPNSGMWDISDHVADDAKYGNHKFTFTSFDDPEERPARIDFLFARATESLRFLTYSILSNRFDDGIFLSDHRPVVADVEVPIGLSCVLEGYCGGRSHGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL18</accession>
    <name>A0ABR3VL18_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="423"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="707" mass="75645" checksum="3C99AEA06CCE21C9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL54</accession>
    <name>A0ABR3VL54_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">VTJ49DRAFT_4551</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04024">
        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5044922944" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044922945" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1022"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="269"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="616"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1080"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="876"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="935"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1022"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1022"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1021"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1842640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1129" mass="124620" checksum="1F0026C3B5D26B6E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLL7</accession>
    <name>A0ABR3VLL7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000033">
        <property type="protein sequence ID" value="KAL1842784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="584"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="725" mass="79131" checksum="6187473CB1CBE82D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLR3</accession>
    <name>A0ABR3VLR3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Negative regulator of differentiation 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12261">
        <property type="entry name" value="RRM1_3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46846" checksum="3D07AE03457B7487" modified="2025-10-08" version="1">MSSLSTSSGSAQVTIDRDYFEKLLRRAQFNTDPAPRNGYQASVVLSRAEYDRLILIAKQYGNLTRNLLRGGVTQETVELLSQDDETIQATHQAVASEAADKDDGGARLNPPPTPHQVQKPVTSGPPVDTAAADRPPHRRASQYQQRSGSWADVDAEDGDYDENGLDSPLEAPPGADYVQPQSQRQQFERNCSRSIQLSNLAEGTTHADITAAVRGGMLLDIFLRSHERAATVSFVNSADARKFFDHVRRNDLYIRNKRVEIKWNDRHFVLPGHVANKIAAGATRNLVLHGYDNRHTEDVIREDLDHIHNLVVVRVEFSSGNCYISLNSVHNAIYARQCMMSRLRYKGKKIAYDADECAQPYPQPPQRKASHRETAPQKKSFAPALHNRFHLLHLDDGDEDDISSSTTSPFQSKNAVGITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLR4</accession>
    <name>A0ABR3VLR4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046779096" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="107" mass="11859" checksum="A8D5C1F08772E760" modified="2025-10-08" version="1">MQLTKALVFAATLATGVFAAPAPDPEPIVLPSRWKSYTSARAATRTVAPPPPPAPTTAQPYNLAAAENCWFQCTVDCGRFTNKCTPLCVNDCMWRWCPQYPARWYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLR6</accession>
    <name>A0ABR3VLR6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047287001" description="DUF7137 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="125"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="298" mass="32373" checksum="48972F39BA6DC7D1" modified="2025-10-08" version="1">MKVSSAGHLAVALLSLTPAVKALQWPRWLPEIETLVVRQEDSTKEDGPSPTPTPKPTATEPPKEDEDKDDEKKTTTTGPLKPIFTDLNTGGLDPTESGTGTGTAKVTGNGTSTRPPKKTQFDPQDPVGGVVMLTPAPTDPNYPLYKIGDYVTWGWNYTNVQATPTAIDLYLKCSKVPQPWTLTQNMSFAEPGSYTWDTQKFQTENVNNPLLTEQYTLVIADAEGGISATPEPGFLAPQNAFMFGMYHPQEYHDTGDGWQCASCSGAMSNIDRRAFGVAVAMSAATVLSFTWYKDSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLX3</accession>
    <name>A0ABR3VLX3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3905</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="521"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="239"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="676"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1179" mass="133071" checksum="FD833FD55659D35B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLX7</accession>
    <name>A0ABR3VLX7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="750"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="823"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="916"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="847"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="916"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="981" mass="107554" checksum="98D1174FE8A3C0FB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM07</accession>
    <name>A0ABR3VM07_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="122" mass="13808" checksum="E17AC36A94280974" modified="2025-10-08" version="1">MSGFYMQYLDSLCRRRGWHEPMYECYRSSEGYTCHVLVNGREYQTDLAYESDHLAQENAAMRAFMVCRNFSVNGGMLARNGIVQGLPVDESSRKTRKGSRHISSGRSRSGHHSSSSSTTSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMC4</accession>
    <name>A0ABR3VMC4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="92343" checksum="DEBF9B8CC3B67DA0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMR0</accession>
    <name>A0ABR3VMR0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="294" mass="32547" checksum="7FF992AF541FF54A" modified="2025-10-08" version="1">MWPWASSSDKPTGSSAAPSEGSQPKKAEAIPSKAPEQNKLPPKLSELVDKQDKEENFFDELFEGYAPPSTESNVRYAAYAARFRTILLSAHRYVAYTSDIGESFRPVAHPWLVRGAYGVSWAYILGDVGYEGYKAYLHNQRALNPQVELSSHQQRILGLEVSEPSPKPRPPTADGPPRAIAPLEDYRTVMLQRGIFQSLASMGLPAFTIHSIVKYSGRAMKDVKSVAVRTWGPIGLGLSIVPFLPRIFDKPVENAVEWAFHKGFEAYGGHEAVGDAPLIGRERQLSERPKEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMZ2</accession>
    <name>A0ABR3VMZ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1843002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="218" mass="24587" checksum="3E0436599BC7219F" modified="2025-10-08" version="1">MVGVIRRLNKLTAKVAMPASDPPLPVVTVARHSARLLLRLIDSINGGHMGPRKFWRTALPRLKYWNPAIPMIVNRIREQEKPATMTLYLREPGAPVKTDVPQPSSSFDGLSKAPPPAEGERIVTINMSNRRSEAILQEFMEKTGAVPVQPTPQDEMELREAEEREAQGAVDRERVKREVEAEKREKRMIAQALSEAAAIKSALRWFDARRVLGEVTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN18</accession>
    <name>A0ABR3VN18_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="198" mass="22459" checksum="9676AAFC45ACDAAF" modified="2025-10-08" version="1">MPNTRFTIHYHSHKCPATSPHDGDDVPPNHPDLKLTPLSTLDRLRYSDSLLLGKSCAEPTCKYVLNPDTVLHNKSHEPIRTLGGKNLYPNRTTPRYMRCCRKLCRNAYTRGHGRGDDVVSFGGEGGMLNHNCAHTLIYQDMIRNYDIGQRLDGCECVMLNVYGEEVEMWGPKGRGMPVKGGPLDLDRRYWEMKEKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VND8</accession>
    <name>A0ABR3VND8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal membrane protein PEX17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26001">
        <property type="entry name" value="Pex8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="72548" checksum="EF2FB90F1E7C5BF0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNE8</accession>
    <name>A0ABR3VNE8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="192"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29764" checksum="2909A9D369C2FBD2" modified="2025-10-08" version="1">MSAPLSDEEKATYTRIIDDILATSDLETVTRKKIRQGLEAAIDKDLSDQKDAIKALIEARFDAISAAAAQVPTPTSGAATNGNHSASEEADGDADEDDGEIQVAAPQRPSKKQKRETSASEDADARLAAELQAQENRLSRGRVTRGAGAAANNKTKARAKATTKRKSAKRVRSDDDSEVEDGDKPKRKAGGGFQKPFNLSDPLAELCGESQLSRPQVVKKLWDYIKANDLQDPNDKRQIRCDEKLHAVFKQDKINMFSMNKLLGNQLYPIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNI2</accession>
    <name>A0ABR3VNI2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="347" mass="39106" checksum="F3570B455CD481A2" modified="2025-10-08" version="1">MVWGWEVGSNGKAARMRSRPAWWGSWMLQPLAVGQLFHAAVFDRDCLPSMWSNLILKASSTYTPYLAPRPEDYPAGLQWPKPSEIVDSLAQMARLSWPAFISPTLFPQKEDILPASLTPIAPITSGAHPLITSLSCATLHPNDPSCSRAFLTCWLRSFGPLSRVLFVIYSALLIPRISALYHYPLSTVRNLISSALRSAGCLTGALATAWSSVCFFQTWLPRTFLQTQRFFLGGFLAGFWAILQQGRRGSRGVFLTTAKTSVESLWKVGVKRRWWRAMRGGDVWVFVAALMLTGVVYERDAKAVREGTWRKGISWVRGEGWRDWAMEEEEEEEEEQVGEEGVRIKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNM2</accession>
    <name>A0ABR3VNM2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000033">
        <property type="protein sequence ID" value="KAL1842763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="545"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="69408" checksum="36E5BC30786D4ABD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNU0</accession>
    <name>A0ABR3VNU0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3047</name>
        <name evidence="3" type="ORF">VTJ49DRAFT_681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="71779" checksum="75AE54131DC57E24" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNY0</accession>
    <name>A0ABR3VNY0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G2/mitotic-specific cyclin-B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="258"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="351"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="355"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54433" checksum="280A64A12F3E91B7" modified="2025-10-08" version="1">MVRATRNLRSVTNENDENTAAPTARVTRAKAAALNVDELSMPSKPLQTKKATGAVANATRKRNVLGDVSNVTKAEAADGKKPAARTGLVSKAAQPTGIKKTTSTRSALTTKEANKKVETKRSGPGSIVAQKRKMMKTKEPAAAKEVEAPEEGEPIRKKVHTSEQDENVQTDVTQEKPATKEPVASPGPEAAAPRHRPPTPEAAKILDSEDLDDPLMVAEYANDIFEYLRDLEPNSVPNPQYMAHQDDLDWKTRGILIDWLVEVHTRFHLLPETLFLAVNIVDRFLSEKVVQLDRLQLVGITAMFIASKYEEVLSPHIANFRHIADDGFTEAEILSAERFVLATLNYDLSYPNPMNFLRRISKADNYDIESRTFGKYLMEIGLLDHRLMGYRPSHIAAAAMYLARLILDRGEWDETLSYYAGYTEEEILPVVLLMIDYMARPVIHEAFFKKYASKKFLKASIIARQWAKKNAPLYGITNTQLTLDEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNZ8</accession>
    <name>A0ABR3VNZ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="550" mass="61301" checksum="10BA091D493400A2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPE9</accession>
    <name>A0ABR3VPE9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="410" mass="44319" checksum="9F6DDA0E26F71B73" modified="2025-10-08" version="1">MPTLPSAISSLPSSSSSPTPEKRPYAPLKSSPLNPNVNAHHQQQRKNTYSSSLGRRRGPGPGLSYDYGHKPGGRGPNLAAPARPHRLSLLPTQESPGQRLLRQKAAVAWRCETLRHHLLGMGRRAPGTATSDTWAPLQPAASSSELRYPRPRQQHHHRSGARCGGENTPLVTIDLGGPETMRVTTQVMTEPEPLIGFLNPSSGGGSSTQRAVERALFAAESYHTRWRADLVVPMPFDDDDEGVGMYRNRDEDEDEGSDYRDNQREAHEATVQSATVTSGRDVGILTASSENLSNENDRDSAKRGSVGVVIYPRPGETSALGCGGGQDSDIEIEPDVGLLSRRRRMLAERRGFLHATRPKVHGSKRLRSTAWRVSIVAAVVLGIVLAYGLVVAFGGSGGRAAGGRPHAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPL4</accession>
    <name>A0ABR3VPL4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045870978" description="Superoxide dismutase copper/zinc binding domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="188" mass="19531" checksum="027D6DE049E4CC01" modified="2025-10-08" version="1">MQRLFSLAILLGVASLTAGQASNVTTGALGDAQPVTTNPEIGETWVATFDSDAVKGTVTAVAAEVGINYTIDVTGLAEDNGPYKYHIHVSPVPESGSCADTGGHLDPYQRRDTPPCESSLPQTCEVGDLSGKYGLLAGGDVKKEFNDAYSGLNTTEVGYIGGRSVVFHDGSGARIACATLVKMEDVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPY9</accession>
    <name>A0ABR3VPY9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="7"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="959"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="773"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="839"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="966"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1074" mass="115885" checksum="1BE5780F85C29893" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQB8</accession>
    <name>A0ABR3VQB8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="307" mass="32986" checksum="773DC959913738F2" modified="2025-10-08" version="1">MAGTPQPVPRQRIFRGIPRDTDLSSSDDDSGQTYIPGWVRRRLFEEKLKKAHAASKRKRVHDDGNPSDQGLFAAAALGNNNSAMNIVDDKTDDEIISTKAQHQLHQEAMTANNPSTPAGRKGNKNMASGFGPGGLPTPWTGKGVPEASVVPSSKRLKNTEARAVAVASAAQNTPTPSRTRNALSSTFTSTPGGNNGNNIEGDEEITISVMGLLQGEDVSPQTQEALRTMLNSHARRARGVEQSRYLLRSEVKHLRDRVAELEEEQRVSRIASAKVAGELWALSQGSGTGTATRIGTQAEDEDEDGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQH4</accession>
    <name>A0ABR3VQH4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1843913.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="133" mass="14331" checksum="B899586E06B352A0" modified="2025-10-08" version="1">MASLIARRAFSTTVRRLSTGERAAGEQALKSESKKNPEIMVLGGVMVAAFAGAGYYFGRNPTKSTSENAVPLAEKSMPWESSSTQGKYKYHPGADPSAAPKDAPSAVNVVVIPDVTLPKRLHDKYNKWGKEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQI7</accession>
    <name>A0ABR3VQI7_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1844185.1"/>
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    </dbReference>
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            <begin position="211"/>
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            <begin position="67"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1844185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="244" mass="25900" checksum="2F1C39A42F511BCB" modified="2025-10-08" version="1">MPCQCSRDVDCPSYHPPSVSDPLNAGSSTILPAYLEKYLLLPTGAPPSGASTPRSHRTLIRSLSNPLPYPDPVPDPEPFPGPGKDTYLTPSGGANPYPPAVSHSAQNHVGGTPLLLRQARQSGPTLAPPAPPTTGLAPDLDPSTSTNILLAAGPRERDLDLDLDRSTDLTIPVPAPGRERDEALVLDDEMVRADLLLPLLRAVLARGASKSVDADEYDEVEEVDNGEDDRGEEKVVDVDCVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_3864</name>
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    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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            <taxon>Mycothermus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="312"/>
        </location>
    </feature>
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            <begin position="342"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="365" mass="40011" checksum="CDA64B27F002B67B" modified="2025-10-08" version="1">MALRPPPPPTIDPANPNIWRWEDMGLTLIHNFITEAEEAALINGFHAHESQKPKQPTNFSTKKRISQHFGYNFDYTTFSASPDRYTPIPDYIASILPRLPQVLPGEPFRLPDQLTVQYYPPGSGIPPHVDTHSAFGEALYSLSYGGAVPMQFRPAGPNDARKMRLPKRSLMSTAASPEPSSASSSPRPASSSPPPGTSSLPPSSGTSKKEEEEDPPAWDLILPPRSLLIMTGPSRYGYVHGIRSRKTDVIPVRMLEHLGQVGVTGLGLVAEQDNGEQDTVTPTERAEEDGEGEKVVVAPRRGRYSLTMRTVEFETAGHCECAYPGVCDARIRQEQLEEQRKTAQSNGQCASTPSDASETKTDYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQX6</accession>
    <name>A0ABR3VQX6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="176"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="676" mass="73432" checksum="9F5C385395253162" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR66</accession>
    <name>A0ABR3VR66_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="5">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1844282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="213" mass="24498" checksum="86DD79288DE2CCB5" modified="2025-10-08" version="1">MDIDDILREVDPTFHSVPLEKRDLQELTRAWVAERSAPELLPWPSNGFFERINDNIKRQIERVEDMTGDMDPKTNFALIVIQTELERYRYLVRSYLRARLAKIDRHALHYLSTDELRARMSDVELAYATRHQALLHNHYLSSFLSSFPPNLQNLNDSAGINMVEAPDLDSAVFVRLLRDTLVTAKGVEDDNAVKGMEISVALIDVESHDTHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRH0</accession>
    <name>A0ABR3VRH0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6876</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="156"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="376"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="540"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1843933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="590" mass="65310" checksum="EBD00433AD15FFF5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRT1</accession>
    <name>A0ABR3VRT1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine-dependent methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_52</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="819"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="99842" checksum="291C63E4C365D55F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0J5</accession>
    <name>A0ABR3V0J5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000734">
        <property type="protein sequence ID" value="KAL1835328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="194" mass="22080" checksum="E567ABEED6E9710F" modified="2025-10-08" version="1">MGVAKRTRKFAAVKRMIGRKDDRRKEEAVKKAEMALKKKEKEAVKEIPQMPSSMFFEHNTALVPPYSVLVDTNFLSRTVGAKLPLLETAMDCLYASCNIIITSCVMAELEKLGPKYRVALMIARDERWTRLTCDHKGTYADDCIVDRIQKHRIYIVATNDRDLKRRIRKVPGVPIMSVAKGRYVIERLPGAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V100</accession>
    <name>A0ABR3V100_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000657">
        <property type="protein sequence ID" value="KAL1835453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="761"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="777"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="818"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1835453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="885" mass="96982" checksum="F22703CC0C45F5F8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1B8</accession>
    <name>A0ABR3V1B8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000599">
        <property type="protein sequence ID" value="KAL1835579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="247" mass="23815" checksum="3B2B39CF5EA63193" modified="2025-10-08" version="1">MPGIPPGALDNLKAKLRAAFRKKGEKKAADDAGEKTEETAAAVTPAAPAEATKTDTAPAPAPAVGTWTDRRRYARGATAETTPAPATEAAAVPAEESKKDETPAAAAPAPEAAATTESAPAAETTPAPVAAATEAAAATPVPEPVAASAAETTPAPAPPATEPTPAPVAAAAEPAPAVTETAAPPAPAPAPAAETPAPAPAEEKKEEPAAPAPAAAEEKKEEPAAAAPAAAEEKKEEPAAAAPAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1U1</accession>
    <name>A0ABR3V1U1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase UBR1-like winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000548">
        <property type="protein sequence ID" value="KAL1835744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR1-like winged-helix" evidence="2">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="701" mass="74126" checksum="547CFF1E2F37EBF4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V312</accession>
    <name>A0ABR3V312_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000455">
        <property type="protein sequence ID" value="KAL1836160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="123" mass="13183" checksum="3548CA49C6A24C61" modified="2025-10-08" version="1">MFDALFNKALKLGVQKGIFAQPKGPSGGIKLAKKDAPKKAAPKKEAAAKKEGEKAEKAEKKKPAKKAAPKKEAAAKKETKEKAAPKKAAAPKKAAAKKVRHSARRRQMKQSEANINPGCSRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V370</accession>
    <name>A0ABR3V370_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000453">
        <property type="protein sequence ID" value="KAL1836169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="318"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="436" mass="48381" checksum="6C5FCEE272CCE273" modified="2025-10-08" version="1">MPDVDKVAQQAEGLSLDEKEAKPMMPELPPGRTLNAGLTLEETLADLNRHPLFMTELDPNEDNEALAALQAIAYEGTPLENAQNFKEQGNESFREKRWSDAKEFYGKGIAILAAEEQRRAKGLPKKVRKTEDKVNLNPNADMSSKPEDLVDDDKDKPKTTNDDDFIEEPDDPAEVQREKSLLETLHVNRAACHLELRNFRSCTLDCAAALRLNPRNIKAFYRSAKALLAVERVREAEDACTRGLALDPNNKPLLALQADIAKATAVVTARQKVEDERASRERRKEALLKAALAARNIRTRSTGRAPDMEDARVKLSPDELDPASALVVPTLLLYPCHAESDFIKAFSERECLEQHFGYVFPLPWDRAGEYSGSAAVECFAETVSGGLVKVGKKVPLLKVLSGGNVEIVDDLLKIFVVPKGRVDGFIKGWKENKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3M2</accession>
    <name>A0ABR3V3M2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000428">
        <property type="protein sequence ID" value="KAL1836330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="172" mass="19326" checksum="3F804E2FBEBF051A" modified="2025-10-08" version="1">MSTSELPSQGGTPSSSSSSTTSPAQFPPQQLPSSQPAPPGSQPGRQPTLTEALTTIKPSDFLTIHQAPCVRPGLLTGIGVGAAVGAIRWIMGLPIPRAANWAVGTGLAAAAGRYEYCQFQRRQEREKVRRVVQVYAERQAKEKKEKEERERQERERREREEAERRKRWWKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3P1</accession>
    <name>A0ABR3V3P1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000416">
        <property type="protein sequence ID" value="KAL1836399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="65189" checksum="8CFDA78961DD564F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3Q1</accession>
    <name>A0ABR3V3Q1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000511">
        <property type="protein sequence ID" value="KAL1835908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="99"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="287" mass="31153" checksum="292DD5A12D46DF42" modified="2025-10-08" version="1">MSRSGYDAVVDVDDEGDLGHTDLQEDLEFHNSNFDETTTARGAGKNSSATLPPPVTAGSSSGAGGGSGGGKRFLWTLSFYAQFFDVDTTSVLQRCWAALYPRANFLDVLEGNPDLYGPFWIATTVVLILFLGGTISDYMARAGRGEFAYDFRLLSGAAGLIYGYTFVIPVALYLALRYFGSESANLLECWALYGYNNLIWIPVALVSWSPITILNWVFVGVGFGLSVAFLLRNLYPVLSATDRQTSKILLILVVALHFGLAVAIKVLFFAHGSPARKDDPGKPGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3R6</accession>
    <name>A0ABR3V3R6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000419">
        <property type="protein sequence ID" value="KAL1836379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="740" mass="82827" checksum="C7AB063CB1F7ACAF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3Z8</accession>
    <name>A0ABR3V3Z8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000465">
        <property type="protein sequence ID" value="KAL1836101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="58"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="223" mass="24542" checksum="65CA4A06DEDE2D54" modified="2025-10-08" version="1">MASDPQRKQGRPAPDPAIASQRQQPPLPGPTALLGSHPYALRPLLQHVPLAADGENGDIKINCVDYYDGNLYIGTSASELLHFFRIPPDQSEPRGPATFILARRFSPKYTEPAGGFNGSRPGVQQILLLPRVNKACVLCNWTVTFYSLPELSPVFDIQVKNCNWIGGVDLNEGHDGPSDRAPGVTILLSLNRRIQVVRIGDDVRSLRVRQAFRTLPDAKTTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V420</accession>
    <name>A0ABR3V420_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000399">
        <property type="protein sequence ID" value="KAL1836533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047325809" evidence="3">
        <location>
            <begin position="19"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
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        </location>
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        </location>
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        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="329" mass="34394" checksum="CBD788D035BB4718" modified="2025-10-08" version="1">MRDSTLFLLASAATLASAGRLECLYTRSSEFANTSPCGDVAALSYCLSHLDVLPTAIQSETERCFVWAGCTASEATTEAARVLGECDHPTNELKLIRRQFISPEGGSAHDAASLPAAVKDSHLVLGRAAAAAPFPITGVPHRPRADSPPTGSPAQCFSQETTETTACPIITTGTESGRRGECVPTVLVNDKCIEGLICAADERGRVNCMYKHSQLDLAGIILAIVFASAIVISIIAICVMCCRERSQHRKIAREAEAAKIAKEAKMQAAVAGKRPGANVTQQPNVEGQPLMYQGAAGAPAAGPAGGAYPPQGQYGQPEQGPYGGQNPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V475</accession>
    <name>A0ABR3V475_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000394">
        <property type="protein sequence ID" value="KAL1836579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1328"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1483"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="8">
        <location>
            <begin position="1616"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1371"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1686"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1750"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1943"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="807"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="901"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="960"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1410"/>
            <end position="1423"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1699"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1750"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1789"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1801"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1849"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1865"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1905"/>
            <end position="1926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1966" mass="211453" checksum="09CAF31293B2568A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4A8</accession>
    <name>A0ABR3V4A8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000390">
        <property type="protein sequence ID" value="KAL1836609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047168753" description="PEBP-like protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21040" checksum="D6E4D81728C2ADD4" modified="2025-10-08" version="1">MLFSTSTITSILLLAGLASAQTPPGFVPEVSEKLEIIFGDKVVQTAGESLTREETARQPTLGTRDAPLTGESYLWMMIDLDVPGNFQNPSSAPRRTNLHALITGFVPSPTPDDATGIYLLIPPSPSAGPVPYVGPGPPPENPPHPHKYVSLLYETAADFTVTREQVGQTFGFDLAAFVERVGIVDGPMRAGYFNVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4A9</accession>
    <name>A0ABR3V4A9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4892</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000391">
        <property type="protein sequence ID" value="KAL1836603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047248152" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="426" mass="46293" checksum="AAC19F33A3A568F7" modified="2025-10-08" version="1">MAVLQSVLLLALALDAGVMAADSSDNTMGPIGFMWPPDRAWAAEADNTAPCGSHDGVTNRTAFPLTDGKVAFMAKDDSYHAELSISYHQDPKSQSDFTQLMATAIPEIDPGHTCYSVPDQPSSIGPGTNATLQIKVTADFDRPENQTFYACADITFVAADAMKGARIPCFNATDDEDVPAPTTTGIPTDLPGHGDEGPPLSTHEPSEEGQGNNGLSGGAIAGAVVGSVVGLALIVGLGLLFYRERARKKRLLEQRDSARATKWIEESLAGKKDQTGSTAGSASIRMGDLPAQNVIGEHQAPLETERHIIQKTVWTRVLTGTLQATKPEAWKQGTKHVVQGTRQAVHRVIPHHARHGQDMYGLNLSYYRDTFFRLDLQTQFDMYMAGRAPKMTKREVDHLRAKTAGFRIRQKYEPWPVIDRSGSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4X0</accession>
    <name>A0ABR3V4X0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000381">
        <property type="protein sequence ID" value="KAL1836665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1123" mass="123058" checksum="A98549D9476CF35A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5C0</accession>
    <name>A0ABR3V5C0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000345">
        <property type="protein sequence ID" value="KAL1836959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15829" checksum="B43E5F21EFEC21F4" modified="2025-10-08" version="1">MSGGKPRGLNAARKLRNNRRDQRWADLSYKKRALGTAFKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5H3</accession>
    <name>A0ABR3V5H3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="JAZGSY010000339">
        <property type="protein sequence ID" value="KAL1837007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="361" mass="38507" checksum="A735C917E2BF0D06" modified="2025-10-08" version="1">MYLTPAARSLSRGTRLATPFVPLVLSATTGTTTAPATSILSSITPTSPVTSPILPLRRPTQARWSSHSPMGTPPANPRKRVTLPMLRDMYAKGDPITMITAHDFPSAHVADAAGMDVILVGDSLAMVALGMEDTSEVVVEEMLLHCRSVARATKAAFTIGDLPMGSYEMSPAQALETAIRFVKEGRMKGVKLEGGREMAPTIQKITEAGIPVLGHVGLTPQRQNSLGGFRVQGKTVSSALRILEDALAVQEAGCFAVVLEAVPPEVAAIITQKLSIPTIGIGAGNGCSGQVLVQVDMTGNFPPGRTIPKFVKKYGDVWGESFRAIEAYRDEVKSRQYPAKEHTYAMPAKELEGFVEAVKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Q3</accession>
    <name>A0ABR3V5Q3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000333">
        <property type="protein sequence ID" value="KAL1837065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="304" mass="34717" checksum="672C0A3799C3C5AF" modified="2025-10-08" version="1">MSVGRASTCLLRALQARSAPQRPFSSTPRRPQRKQAADDPNFVSIVDNPPELVRAGRRHGPGLIILAIIPVTAFFLGCWQVKRLAWKTDLIAKCEDRIVRPPLPLPPRVDPDAVADFDFRRVYATGRFRHDQEMLVGPRMREGEQGYMVVTPLEREDGAKVLVNRGWVAKSKADQAKRRAGLPQGEVTVEGLIRKPWKKNMFTPENRPDKGEFYFPDVKEMAGLTGSQPIWIEQTMDPDYFQLLEYLEKGVPVGRPAEVNLRNNHVQYIITWYGLSLATSIMFYLVVRKPPSNITQRVRMNKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V654</accession>
    <name>A0ABR3V654_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4624</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000363">
        <property type="protein sequence ID" value="KAL1836808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1836808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="204" mass="22908" checksum="D9A6CA4D0D479769" modified="2025-10-08" version="1">MLLEEDPSTLIRHTVSNFNIAPDKAAVSRVSELLSTLQEARERRLREGEAALRKLARTQATLTSQHAELAASHSSARHASDMARLDTHKFRVAKAASDLEMETERLQAQLDELRARLQELELQGVDGAVAGNGTGEGGSGGVDDEVLLRLKVYRSLGMEIERDDKDGEFNRVIVRNDRKGDVHVVNIDRKFSRFFYANYFWNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6K8</accession>
    <name>A0ABR3V6K8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000298">
        <property type="protein sequence ID" value="KAL1837397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF2">
        <property type="entry name" value="BACTERIOPHAGE T5 ORF172 DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="3">
        <location>
            <begin position="665"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="793" mass="86081" checksum="10CF5F87FBD43980" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6L7</accession>
    <name>A0ABR3V6L7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000329">
        <property type="protein sequence ID" value="KAL1837101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045319868" evidence="1">
        <location>
            <begin position="22"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="220" mass="23010" checksum="1792CBA167D7E2F8" modified="2025-10-08" version="1">MRRHRAALLGWLCASSIGVHGQSTVSVYLPEYGDSDWAALRGSVLSSDASTTVYTVFCADCQIAADLPFVFTEGPSTLVYKGENPGTLTADLECRLEGTTAATCTGSSSFGSGYRGPSITGPTETVWTSTFTGSDVTWGVLTLSTPPPATSTLDLEGTVVSSQTGEPVPTSGADGRLRGGLMASIGAVVLGLLLRRAVVTCRAHLMPTWFATFRRQSFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6V7</accession>
    <name>A0ABR3V6V7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000318">
        <property type="protein sequence ID" value="KAL1837206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="415" mass="46268" checksum="B6E8804DD0E62E5E" modified="2025-10-08" version="1">MPSFTTPTNPGRRLDDRFPGLRLRPAQAYDLRRMARMANDVFQHERDIDYFNRHRAIKMGNEREAAAAECLLAAECEWRHASLRNCRRLPGRHLIVATYLKKPADYLCGRSLASGAKEEIVGWAEWQDPLMTPDDVSDPCNTVNEEDNLKPRDDDMVRFNIVLDDLTLDYEHERLLVLPNGLAIRFDDALDSMQRAAAGAFAANSRVWKMWCEEVIPSCFDRWGDVKGRDLVLRSLVISTPHWHDADGIGRLLLSWGATRCTEKGWAGVQTVASATGVSTADALLAAGFVERPGSPGLSRLAMFRDELVALHWPRDRFHIACPALGIALAPKTQQRRRRPLAPRSTNTSAATTGPRKRPRGKAAASETYEADTENPHKRPAGPARSLTNRNMEMGDTVGAAGLMTLVPQSQVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V739</accession>
    <name>A0ABR3V739_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000282">
        <property type="protein sequence ID" value="KAL1837560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="412"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="559" mass="58113" checksum="85A0D55371A16627" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V745</accession>
    <name>A0ABR3V745_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000282">
        <property type="protein sequence ID" value="KAL1837561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="622" mass="67826" checksum="4459CED90D7457AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V795</accession>
    <name>A0ABR3V795_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000274">
        <property type="protein sequence ID" value="KAL1837660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="296" mass="31267" checksum="73D0BAE4A9B25523" modified="2025-10-08" version="1">MSDALTDEIEAINSIYGDDTLTRSAQDPDGDIFILTLPGETASLRVQFPPTYPDVPPILLGTHSSGTSGKRGTAARDLALFRDAVSEVYQPGQVCLFDAIEKVQELLAAVAEGQDGTDAVADEDTGGAESGQNANSDGATAAVPDQEAADHLGPPPPWTISAVFSESKSVFVARCAPVTSPSQATSYLAHLLATDKRVRAATHNITAWRIRGPNGTSFQDCDDDGETAAGGRLLHLMQLMDLWDTMVVVTRWYGGVKLGPRRFALINQTARDAFVRAGLVKEEAPAAGGGKKKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Q8</accession>
    <name>A0ABR3V7Q8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000260">
        <property type="protein sequence ID" value="KAL1837822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="173"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="569" mass="63247" checksum="04F3486CD9BE7385" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8H1</accession>
    <name>A0ABR3V8H1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000270">
        <property type="protein sequence ID" value="KAL1837706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
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            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
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            <end position="94"/>
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    </feature>
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            <begin position="106"/>
            <end position="127"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KAL1837706.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="537" mass="59328" checksum="1C2784BC1C3AABD8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8S6</accession>
    <name>A0ABR3V8S6_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_2986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1838160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="44759" checksum="CC82779ACF352F8F" modified="2025-10-08" version="1">MSRLTQRTRIVCISDTHNTAVKLPKGDVLVHAGDLTNQGSYSELSKAVQWLEKADYEVKIVIADEAFYAQHGSNFHNQIPQDSAKCRALLASSRSIIYLEHSSVTVRLKRPDGPRTEFTVFGSPYSPQYGTWAFMYPRADAGAAADADTTADASGQRGSSGDALSPNKTAAALWSAIPLTTDLLITHTPAATHRDDGCGCPELAKTLSVVRPRLHVCGHVHQARGAERVMWDVDGRPAEEDPAAAPAAAILSREPWQDPNPDPTSAKISLVDLTSRKGNRPLAFYEGLVVVAPPDETPNAPHVAAGPTSGWSDGASHLVGDTVERQSGEQAPFGPADSCESGVRQPDRSGRRETCVVNAAIMATGWPHVGGKRLNKPIVVDIDLPECVFYCRSRFLETSRPLATGAACRTGCDLFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">VTJ49DRAFT_2939</name>
    </gene>
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000230">
        <property type="protein sequence ID" value="KAL1838212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="569"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
            <end position="212"/>
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            <begin position="125"/>
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    </feature>
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        <location>
            <begin position="165"/>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="569" mass="58816" checksum="B1613B7A59F426B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V932</accession>
    <name>A0ABR3V932_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000279">
        <property type="protein sequence ID" value="KAL1837603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="182" mass="19555" checksum="AA4E5B5E15B06606" modified="2025-10-08" version="1">MSRRTTDPVRPNPQLRWPTVIAYGAAAGLVGVAAMTATERIEQFFTSRPSSQVPGRTLARLLAWMTTTAAGSSSSSVKSIATPAAAEADPAELVRLTWIMHFGQGAVVAVVRAVAAYAWGVRGPVADFLFAGVRLGVDQTLENLTGVGALPWTWPVSEQVIDLLHKTVYAFVTGYLTDRWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V957</accession>
    <name>A0ABR3V957_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000228">
        <property type="protein sequence ID" value="KAL1838237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
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    </dbReference>
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            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="39"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
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            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="552" mass="59468" checksum="9746708BE3D7E15C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9B7</accession>
    <name>A0ABR3V9B7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uracil catabolism protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000214">
        <property type="protein sequence ID" value="KAL1838433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF1688"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN URG3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07958">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
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        <location>
            <begin position="24"/>
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        <location>
            <begin position="40"/>
            <end position="50"/>
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            <begin position="51"/>
            <end position="67"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="58636" checksum="9AEB8E8578964954" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9C9</accession>
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        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
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        <name evidence="8" type="ORF">VTJ49DRAFT_2711</name>
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    <organism evidence="8 9">
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000218">
        <property type="protein sequence ID" value="KAL1838370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="215" mass="23686" checksum="F9670D32EBBE8C4E" modified="2025-10-08" version="1">MGTGSKVGLVLFRVWQIICAAIVLGILSRFLLLVNQAGAWRDGRIIYGIITGSISLVFSIVFIVPFLYAFMGFLMDFILWIMWLVLFSLLASRTTGGRCSSHWYYDYWGYYWGRWWLTPVRITGPWDIAWAGCSSWRAALAFSFLAMIGYLVTAILGAAVVSKWRNKDKNERRTGTPAVNSTTQISGPTNVTGGPTHTGAVGGTTTAPSQPANVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9D6</accession>
    <name>A0ABR3V9D6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000214">
        <property type="protein sequence ID" value="KAL1838440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="660" mass="74057" checksum="0E19B48BDC91711C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9J0</accession>
    <name>A0ABR3V9J0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000224">
        <property type="protein sequence ID" value="KAL1838285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="478" mass="52288" checksum="18B658C9018C466A" modified="2025-10-08" version="1">MDNLQFFNVINDELRSSTTTERVTDPRTEEPLWPWPVASTQDFEDAVAAAQHAFNSGWGRSTVSERQEKLKQLAEVLRTHADELTTILMRESGKSRILAGIDVAASVDQCLYYARPESALRDEVQSDDERGKVVATHIPLGVVAAICPWNFPLILANMKVVSALVTGNCVIVKPSPFTPYAVTKWIELSRGIFPPGVLQVVNGGADVGAAMTEHPGIAKISFTGTIATGKRVMAACARTLKKVTLELAGNDACVVCEDVDLDRVVPAVASGGFFNAGQVCVASKRIYVHEKIYDQFLARLAREVQDRYAIQDDPNAPSVFGPLDNRPQYESVKRLIEDCKAKGYEVITGGETQGVRPKGFWLPPTIVAKPPEDSELVQEEQFGPVLPVLTWSDEDDVIRRSNLANAGLGASVYSSDLERAERIARRLEAGSVWINQPERPNYAAFFGGIKDSGFGGEMGRQGLLSYSYTKCLHFPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Z6</accession>
    <name>A0ABR3V9Z6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-mandelate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000206">
        <property type="protein sequence ID" value="KAL1838588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="98"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="194"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="43042" checksum="30CE5392474E4D71" modified="2025-10-08" version="1">MPPATPDPEPVPMAVSPASQPLTQGTTKPKRLIVLHIGDPIKFNPKTYAEFGEAFDVIRPSAAERERGEFMRALRERRWGDFSAIFRPFWGSGGEMGKWDAELISLLPTTVRVFASAGAGFDWVDTRLLGERGIVYCNSGLAAAEAVADFAVAMIISTFRHLPWCMGAATVGAISPSSAAEDAFRACHLLATAASHNPRGHVLGLIGLGNIGQQIAAKMGSPAFGMRIVYHDVERKPAALEIQLGATFHSTLDSLLAVSDCVVLCTPAFPDGKPLLTASTFSKFRRGARFVNVARGSLVDEDALADALERGDISAAALDVHAAEPRVNPRLLRMATDLVPRDGGTSPPGPGRVMLTCHNAGGTVETHEGFEELSMRNILAVLTGGEPITPVNLRFLKKREGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA86</accession>
    <name>A0ABR3VA86_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="86"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="400" mass="45055" checksum="33BCE545B9768C93" modified="2025-10-08" version="1">MDGKRNSLDNPRSSTRNKRPRLSAEMTELNNVQSSQPEGHLGNTSTTSKEQDTSSNSVPRMTATIDLVTLTAEHDFDAANVMDRHGDLTLIVKPHGTAFKVCSRALARASPVWDELLYGRHSENNSDPRSDDSVSSSRAKSLEALRIILRSVHSNLTSIPPDLDAETLVDLAVMCDEYKILRLFERNWPEWTMKAKELARGDELKIAITLRIFWILGCEAEFAEAFRLLVFQAHHAKEFNSWLDYADVMEENEHIRAMGFAKHLASAREVLIACLWSTSEEAVETLSRADSENCQDNGVSGTARACDCAMLGALQRTPRSRGWRNLRDFRWLYTNTRNVSVSGLLAELEELRRETIIESGMAESHKNCGPWDAQRFTNVEQDAHQISKTGDNVGRYIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAY2</accession>
    <name>A0ABR3VAY2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation chloride cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000181">
        <property type="protein sequence ID" value="KAL1838988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="23"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="8">
        <location>
            <begin position="495"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="889"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="956"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="130712" checksum="D1903B1E5B24479E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBA8</accession>
    <name>A0ABR3VBA8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase ROK1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-dependent RNA helicase rok1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_2428</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000200">
        <property type="protein sequence ID" value="KAL1838676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="1228"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="1482"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1014"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1122"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1317"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1665"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1078"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1125"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1154"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1317"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1330"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1683"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1726"/>
            <end position="1736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1838676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1736" mass="191938" checksum="EC61CA4150D7E272" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBC6</accession>
    <name>A0ABR3VBC6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_1991</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="JAZGSY010000180">
        <property type="protein sequence ID" value="KAL1839016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1839016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="252" mass="27194" checksum="6F7B8269BC274856" modified="2025-10-08" version="1">MAPKAIIAPSILSADFADLGAECSRTIQRGADWLHVDIMDGHFVPNLTFGPPVVAKIRSHVDRPTEKHGRGTFDCHMMIAEPKKWVKEFKKAGCDLYCFHYEAAINSTAAESPEARSDTKTSPRELIRYIHDQGMLAGIAIKPATPVDVLYDVLDAEDPAERPDMALVMTVEPGFGGQKFMASELPKVQALRERYPELNIEVDGGLGPGTIDQAADAGANVIVAGSAVFGAEDPAAVISLLREAVEKRAGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBQ5</accession>
    <name>A0ABR3VBQ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000166">
        <property type="protein sequence ID" value="KAL1839273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="29"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="253" mass="29146" checksum="65BD330B0F549735" modified="2025-10-08" version="1">MRFRDSMARHFGDSLSTSAPKPYLSYYDIRLDTEDIKALKHDWLTDSAIAFWEEWLEREILPQYPQARIVLLRPVVSHLLLQTTDLKNDASALPDFRRVTHIFIPISDSRDRWNADSGSHWSLLLVSVIDRVAFHYDSLGGSNFSAARRAVDRLGWVLNMQLRFHQLEDTPQQENGKDCGVFVCILMRHLLVKRLLNASHDEKVSMSMSGKMIDSRGGRKEMLRIIESLRKEGERRRSASPFAGSPNDPPRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC02</accession>
    <name>A0ABR3VC02_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000179">
        <property type="protein sequence ID" value="KAL1839027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="115519" checksum="07AD81D5164E15DF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCM3</accession>
    <name>A0ABR3VCM3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000149">
        <property type="protein sequence ID" value="KAL1839594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="133" mass="14736" checksum="6CB7C429B733465D" modified="2025-10-08" version="1">MATCIFCKIIKGEIPSFKLFESDKTLAFLDIQPLSQGHALVIPKTHGEKLADIPDDYLTEILPVAKKLAIATGANEYNILQNNGRGAHQEVPHVHFHMIPKPNVHEGLGISWPAQKSDMDKLKALAEEIKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCN7</accession>
    <name>A0ABR3VCN7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tho complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000172">
        <property type="protein sequence ID" value="KAL1839156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42300" checksum="0D9C2A9A4FB10787" modified="2025-10-08" version="1">MSSWGLLDDKEENELHKSRLLNVEEKPFKRITKRLNTLYTFAASRARQTATPPPETNGVDGQHNQTDGTPTAGDTTSLDFAQLREDVTLDFAAFDSSIARLQFLLAANERERERYAAERERIIAASQTVRERTSQLRTQLDQARATLAQRRQFDALADAITSNPSLRPRAEQAAALQKLRDEIAELEAEREEYGVTWNERREQFARIMEESMRLRRLIRDEKEEVERREGMDEDGDGDAGGGGVGGGDGTTPRPSHGAVSREGTPKPEGGSGLVPPNKGGAETGDDGTPRDLSVGVATPASDSPAPGHESQSSLVAKRAVGLSTSFSQVGSERGSREPSVEVGTAQGSQAGDGEDVEMGEAKAEESEEPSPGPAEGTPQIVVEGDGEVMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCW7</accession>
    <name>A0ABR3VCW7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000143">
        <property type="protein sequence ID" value="KAL1839715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="562" mass="61503" checksum="0F059CA1A7364958" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD06</accession>
    <name>A0ABR3VD06_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000166">
        <property type="protein sequence ID" value="KAL1839276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="316" mass="35216" checksum="AC25C8FD42A355CB" modified="2025-10-08" version="1">MFVDQGTDHLVPSSAPDITISANMEAPGEQSPLQSRPKLDFTTPPSFQPRKAADGLRVNRRHRTDGPLPAEVRNAFLVEEQPRMAASQPHLHGQDCFTILHRIVNLLHRSLKPKEEIVREIAADYRENATKLLQNLSMRHDQEKKGIFAALRRASQTLFSIFSSAKQDLAVLIENIRGMDITHTGDVLTRPALTQKLDAVAKLCRARLRDNGTELPDGEGLNGPDHDELQHSYQQRLMNALHGVDDQTRDSLDKIASEVDDFIQQCLEGKMGVIVQREENAPEKPAKKVENADEALEVLLDGILDSLKDNGENGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDC3</accession>
    <name>A0ABR3VDC3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="52"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="300" mass="29858" checksum="5A73F03B1F1E89D0" modified="2025-10-08" version="1">MDKFLGKAVESALGNDSDNKPQVQAPSGGNVTSGGAYPAGGNYLDAVSGNLQGTASAAAAKHAPEEDSNLFSDVLGKLLQSKAPEKIAEEEIDEEAAVQSHQRFFGSSSTTTTTSTSQQQSQPQQEPQQATSSNLGSAAALEALKLFTSSSSQSSPQQNSQSAFIGLAMAQAAKLFDKQASQGNVAAGTDKQSVVMKAGEMALKMYLKSHGAGGNAGNAAGASGGGLSQGLAALAGLAGGAGGAGAAPSGVSGQQQQQQASGAEGLLGLAEKTRPDNSNPSPARLGSAPRGTVQLHWTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDK3</accession>
    <name>A0ABR3VDK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000135">
        <property type="protein sequence ID" value="KAL1839915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="541" mass="60002" checksum="031F57B2D4ECEDE3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDZ9</accession>
    <name>A0ABR3VDZ9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047247617" evidence="1">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="190" mass="21000" checksum="31917555859467FF" modified="2025-10-08" version="1">MFHRTILNTAVFLLGVRLAIAIPLESSGASEPKEIGDRCGTYDGQFLGDCADPLTCIPLSPNCTFFRDPWSSATGCPGTCQEIDISQQRIYTLCGGWHLYDDCDERIEQCSVDPRNRGCGPPCDAGGICIPYEDTCTQGKKCREGTVCFEKTGACLPLRFGSDSYEKTSREHVWVDDDEITRPDWAVKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE16</accession>
    <name>A0ABR3VE16_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BING4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000141">
        <property type="protein sequence ID" value="KAL1839762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="8">
        <location>
            <begin position="377"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="551" mass="62641" checksum="129BA5680B6CED24" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE19</accession>
    <name>A0ABR3VE19_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="180" mass="19439" checksum="5A413F2DC53B1757" modified="2025-10-08" version="1">MSSQRPFFLSTFFAAFRQTPASLSTASASAQQPNKPSTQPSAAAAAQQVSASNPRSISTAATATASSSQATSPSSRSGGVMSHLPLHTSRHHHHHHHQHQHQHHSHHHSAGIPIPQNGRDNHHGRRRGSDSSSEGFREALGADKLYIGGRTATGEERFFKLGVVRRIRSGDRLSLDRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VED2</accession>
    <name>A0ABR3VED2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000141">
        <property type="protein sequence ID" value="KAL1839771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052293">
        <property type="entry name" value="SRRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239:SF41">
        <property type="entry name" value="MEMBRANE ASSOCIATED PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239">
        <property type="entry name" value="PROTEIN CBG20215-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="737"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="872"/>
        </location>
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            <begin position="1044"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="630"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="654"/>
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    </feature>
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        <location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        <location>
            <begin position="807"/>
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        <location>
            <begin position="1044"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1100"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1101"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="1160"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <location>
            <begin position="1303"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1839771.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1452" mass="154280" checksum="4180431C768A6C34" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VED4</accession>
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        </submittedName>
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        <name type="scientific">Humicola insolens</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000129">
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    </dbReference>
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            <dbReference type="EMBL" id="KAL1840067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="151" mass="15945" checksum="C5408AFCA60CE4E6" modified="2025-10-08" version="1">MAIFNGGVSTGAARRSVALLHRPARRRRSVEHQMLGLGGPCQSMTKSSKVTRFVFAPPSDLAGSLVRADLAAFPDRPELDKFKHKEGNSLPPPSSGRPCRACGQAAGVVFLLPPASFLMNREPCSDGAKLHLSAPATPAYLGLVGVANANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEK6</accession>
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            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046854017" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="291" mass="33562" checksum="D4A69CB127A23E5C" modified="2025-10-08" version="1">MFLTRLNSLLIFLRLRRSDPWSPRTPLDWILYSPLQWLAALLYRNRQVDWLKSLPHRWKVVIGGNHDLCLDKSFERKLSSAGRHDSGEKVFDEQERQQQEVNWGGIEYLCDRAVELRFEGGRRLNVYGWGAVPGLGEDHALSYPRHRHPWHRRIPDETDVLVTHTPPAHHLDLGLGCAGLLDEVWRVKPRLHVFGHVHRAHGTEPVYYDECQRAYEAIMSRRPQGGPLRDLLLPGPHWLDVWDMVRHGIASILWKWIMLGPGTNNGGLMVNAALMYGDSGVLRNPITVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VER1</accession>
    <name>A0ABR3VER1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000117">
        <property type="protein sequence ID" value="KAL1840339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="363" mass="39355" checksum="83141C347AF19ABC" modified="2025-10-08" version="1">MADTEPTPADAPAAPIMPVAIFKKRGAKAKANLRKRPATPPPAANSDSDDSSDFSSSEDEATGQRVKRRKRNAGGGVVVASSKDASANNKKDGEEEDVTAATVFKADRTLDLESGKREATKHANWFDDDENMSAKNLLGSTRSLATSKNKAATTTNSSAAEEQPQKRAVGPVKPPPSHIRTITITDMAPDVCKDWKQTGFCGFGDGCKFLHAREDYAHGWQLDREWEKVTKGKKVLGGTVVASAERKATGKKGQEDEDEDEAEAAMLEAIPFACIICRGPYKSPVVTRCGHYFCEGCALGRYRRDPSCAACGAGTNGVFNAAKKLQKLLEKKKEREERRRREARERGEEVSDDEEGQDGESDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF34</accession>
    <name>A0ABR3VF34_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000114">
        <property type="protein sequence ID" value="KAL1840425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="339" mass="37017" checksum="5C8778D0F070D3FE" modified="2025-10-08" version="1">MSANLPERKNDNPGGAQADNPKVLRLRNSNGTVHVPPLAKKLLEKCANRVEAECLLQAVIACGIFGHGSARRMTAGLAKTFQKDIASNVWTPPRLEPRFAFVKKGNQLHGISLTVLAGSDSFVDISLARGNDRDDGEHLNPPAMKLVKQAVNRWQPEMTPATYAWDTITLMDARYIDQSNDVTYNDIICDFPDEASLDHLFEVPQGLSAGQMPAIRCATRSDIGTDQPGVQETQGHVSQSDLLATIANEQPEGAGHEDRPDPVNEENSSHLARKALQRHDRAKKKLKAARKAMRRAREAERHALMQYYKERVAELEGRLAAGATGSEGSETEDGDGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF41</accession>
    <name>A0ABR3VF41_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000118">
        <property type="protein sequence ID" value="KAL1840313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="121"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="990" mass="112057" checksum="9C86D609CBBB2D96" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFD3</accession>
    <name>A0ABR3VFD3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_951</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046342692" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
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        <location>
            <begin position="564"/>
            <end position="597"/>
        </location>
    </feature>
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        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
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        <location>
            <begin position="643"/>
            <end position="758"/>
        </location>
    </feature>
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        <location>
            <begin position="718"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="758" mass="82453" checksum="601EF5683BFD607E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFN7</accession>
    <name>A0ABR3VFN7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1840627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
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        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
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        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
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        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="557"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="296"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="914" mass="101283" checksum="83DC73D4951994B4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFT4</accession>
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        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_336</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000108">
        <property type="protein sequence ID" value="KAL1840562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF23">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="322"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="13">
        <location>
            <begin position="848"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="12">
        <location>
            <begin position="1249"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1206"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1219"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1330" mass="147867" checksum="1EEC3D1A142C1097" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG59</accession>
    <name>A0ABR3VG59_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="251" mass="28027" checksum="C726B51497652E96" modified="2025-10-08" version="1">MAPRPYVVGDSSPFLKRVLIPFWVIRILIMFIQIIVYGLIVAGLGLYKEDAKRLSDQYNTGLNYDAVLAVSVIIMLIVLACLILDIVSIVKRAKRTLSPRFFLIINCIQTTFYLVNFILSMIGPRTAAAIVINVIIFLSFLGLLIYAAVVFHQFRTGKLKGGTYVQTHNPEVHNLVPGSTAYPSQTGSYPPSEYPPKPEQPYYYGQQQQQPAQYAGPQAYEPYAHRPVEYGQAQGVTGAPPQPGYEMQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG82</accession>
    <name>A0ABR3VG82_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000126">
        <property type="protein sequence ID" value="KAL1840121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="76601" checksum="527BA5570DCA7320" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGA2</accession>
    <name>A0ABR3VGA2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="166" mass="17534" checksum="123F50ECF5AE4129" modified="2025-10-08" version="1">MAPLTPGSDFPQGVTFTYIAPTASLDLTACGLPIKYDASKEFQTGKTVLVAVPGAFTPTCQEKHVPSYLASLDQLRAKGVTRVIFIASNDAFVMSAWGKANGVKDESILFMSDPKAEFSHSIGWANDDRTGRYAIVVDNGKVVYAAADTVRGSIENSGAAGVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGA9</accession>
    <name>A0ABR3VGA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="827" mass="90776" checksum="9D1531D5CA7D30DD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGG8</accession>
    <name>A0ABR3VGG8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhnB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000115">
        <property type="protein sequence ID" value="KAL1840378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990:SF2">
        <property type="entry name" value="PHNB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990">
        <property type="entry name" value="PROTEIN YJDN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhnB-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="166" mass="18788" checksum="996FB991094A6349" modified="2025-10-08" version="1">MSLSLSKLKLTTCLWFDGQAKEAAEFYTSIFPNSKILHIQQHIKCDDKIDPNDTVLVAAFELDGHQFVGLNGGPQFKFDEAISFQIDCANQEEVDYYYEKLSEGGDPKRRDCGWVADKYGVSWQIVPTVLKTMLASEDKEAAMRVYQAMNSQVKFNIAELEKAFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGP5</accession>
    <name>A0ABR3VGP5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045283500" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="42"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="250"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="666" mass="71384" checksum="4433BC44773A4D29" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH38</accession>
    <name>A0ABR3VH38_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56000" checksum="10CDD580F9095757" modified="2025-10-08" version="1">MEGDHTRPALLSKVKSKYGRCDYQRFDNIASTHMRAGHGTIGKVEVDCRFLFTKSLWGVIGEARNPAGIILLDLDISQPPDCKLQSAAVTVTLSEEDGVEARIKRRSPCPVKFTDYFGPKSLRGEESLVQMRKTKNRTPEVQVLGYGAGGLGVNREKVVETTGRWDFSGYITSTKDSIWYNQLRWELKESSLEVQPTHNNLFRTAFALEHNATRFYMTVHVSGKLVKFSEKVKDKLRFGDKKIKDEKVVTKIEWSGGYSCPMRLDEVAQRLDEFMRSENKGQVADEVPSALATSYHPVNASQSHAPPQFVPLAHSPSPRITLQPAPQQPILGAWFAPTLPSPHEGGLSTVTHPLQHLPALTINDLRMAAAGYAPADPSRPPPPPQSSTFSTAGTVTSEVSDDSSSTTLVNSATPREETPGDPVSDTVGKDEKDEESDEELERVPEGGKNMSLDAPWLGITAMLLEWFATMGLLLWGLKTVAPGHLKHQRHRCMLCEVDSEDGVLLGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH73</accession>
    <name>A0ABR3VH73_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="265"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="486"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="706"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="780"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1147"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1203"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1248" mass="136120" checksum="2EDE57C97A2589CD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHC1</accession>
    <name>A0ABR3VHC1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000085">
        <property type="protein sequence ID" value="KAL1841146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046579187" evidence="1">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="152" mass="16559" checksum="0227C93D3851A36D" modified="2025-10-08" version="1">MKLTALFASGLGLFAWAASAMPLEERDDEAPQTVHLTFHGGPASYNLTLLADGNYYQTNNELSVSIIEAPDYNAFYQCQFETVNEATLASSISPAGVNQILVGPPTPITAVRCEGMCVHTWGECYRNNQYVGPCCSGYCAATRCRPWVYTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHD1</accession>
    <name>A0ABR3VHD1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="183" mass="20192" checksum="A09191AFF16124E7" modified="2025-10-08" version="1">MCPQEVLVSNPNMDSGNHNENDRSPNANTRDVDLFALAAGDVVVETPGATAGPTERSDLAMLHAAQDVLKLLTELTPRVEKMIPYLKDADRNELTITAATGSVNSNSPSAQRAIKILENVRAMAEAVTDLRRMMKDTQILAECQVLDTTCTAYMNGAINDEQYDCHLEPAGILSRRQSRYNWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI33</accession>
    <name>A0ABR3VI33_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="261"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="775" mass="86773" checksum="BB1D8AC6113E2C80" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI57</accession>
    <name>A0ABR3VI57_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000073">
        <property type="protein sequence ID" value="KAL1841512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33381" checksum="59181389C1B27D77" modified="2025-10-08" version="1">MPYLRDVSYSLEETVAAVSDYFDFLVKLYLPESLILRPPEGGWPEVNSERVQGLGKSDEVIKLLRHLPYINENPSDLSGIDGGPSGCKFYNWLRRFRDLDRPDADPTTVFESAKTMTEPIEEEFVVPPHVVGLLSTKDDLFLLDTQLGIIYWYECPGSIQASPTREPVWDNPDEDPLDEREGEHWRCFPAWAVQDFFELLKDHFREQRTVPVSPITVYDLDNFRWSSKVKDEVMPLVKATFREHGWPDLDRYRKEECLQAVRRIMEQHLGEQHCGGYWPDWLAEGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIK7</accession>
    <name>A0ABR3VIK7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000066">
        <property type="protein sequence ID" value="KAL1841718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="166"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="459" mass="50240" checksum="B89A9D2FF9F84395" modified="2025-10-08" version="1">MDPELTHSADTPLAGRAASPKPTRFLRASETTMLDGWRQNARETSVSWTPSSKDFAEFPDADNVGPQDYFIQEFNRLAQEVGPILPSTNPFPVPRPQQLRRSWISRTFRRQVSEAHSPNSTQLDKKIKKRRSVGDLALHLVNGAREDNLKGRDLPTLVRLCGKSTLHLPSEYSPGSLILPTCFRATAHYLVQHGPNTRGVFRIPGSVRTVNALYSYYSADGEDSDDISSTICSPSLPSHINAGPHEVGSIFKRLLSGLPGGILGSLLLFEKLAEVQKTHKTKDRGRLIALAIGATVKSHLQQDLIFAVFGLLGLIGRAAEQVPRDLEPRRSHPTSDLMGYGALGIVFGPLLVGDLLHSYNIPAVDDASSSNVAPTPPSNMKIEGRATNAADGSLSQALIVDRISVANGVAEMLITNWRDVVRPGYRCSRLGQSAQESFRLRLPLSLISYEFRTRIANPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIS6</accession>
    <name>A0ABR3VIS6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">VTJ49DRAFT_6689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000066">
        <property type="protein sequence ID" value="KAL1841715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="327" mass="35923" checksum="1606072AC7F2C1FE" modified="2025-10-08" version="1">MSSHPHTPQSPSQFSPNVSDLTMSMTGSAASTTTTLPTPAHSVNGSSLPSEMTQDTVMSEDSPHKRKREVDDVGDRAQKKVQVEDRRRGIDNLHLDVGEKYLLCRTPHPTPRPQISEDLFERYGLTGLASEVARVLPNGEKNALRKTYKGHIKKLGVQGHWDEVKEDPHREFGLLYLMKLPQDVWDSTQVRGQNIKDGFSNEARQKMLRAMTMGRGVVPKALWDSSVLGDMAPGKAEKLTGSARPTAPNTPLPTTTGMPGVPRSKVGTPQFSQDPARSSKRNIKKRSYGDSSFEGYGEGFPDDIEAGYSTGEGDGGQKRRKKVLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ87</accession>
    <name>A0ABR3VJ87_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000091">
        <property type="protein sequence ID" value="KAL1840991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="165" mass="19130" checksum="E6A5F3272FF0EEFC" modified="2025-10-08" version="1">MDISENNFPGRTSIVVQNQILTPAPSIDVVIAPDDRFNYALTGDSRYYIRASVQLLFHGGSEDGLPVPRHHITRYLMGTTHARPQNLTMDQDGYLSMTFQWNDLRLLRSRWFRFQVELSLCYSSTDHRAYPGVEDSSTIDVGEEFWVEPDPRFQPWPRDEGYYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJA3</accession>
    <name>A0ABR3VJA3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="98"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="485" mass="53385" checksum="75193343AE59C8F1" modified="2025-10-08" version="1">MGSDSGRRLNIDNINPHVRAAKYAVRGELAVKSEEYRIALAKGATDLPFKQVISANIGNPQQLDQKPITFFRQVLSILENPHLLDKPDVLVNELGYKPDVLERAKKLLKAVGSVGAYSASNGAPAIRQSVAEFLERRDGFPANWEDIYLSAGASSGVNTLLHIICKDSTSGVLVPIPQYPLYTASLSVLDAHCVPYYLEEHKNWGTDVSAIRAAYDKAVADGIDVRAIVIINPGNPTGASLPESDIRAVIDFAREKRLVVLADEVYQTNVFIGEFISFKRTLRLMQQESPGKYDSVELASLHSVSKGMVGECGHRGGYFELVGFDPHVQQEIYKFVSIMLCAPVIGQCLVDLMVNPPRPGDPSYEQYQAEYDAIYHGLHERATALHKAFEQMEGVECGVPQGSMYLFPTIKLPPKAAEAAAAEGRTPDEFYCMRLLEATGVCVVPGSGFGQKEGTLHFRTTFLAPGTEWVGSIVKFHKEFMDKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJK3</accession>
    <name>A0ABR3VJK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosyl-DNA phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09194">
        <property type="entry name" value="PLDc_yTdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="60857" checksum="D28130FFDFE8437D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK70</accession>
    <name>A0ABR3VK70_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000064">
        <property type="protein sequence ID" value="KAL1841758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="435"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="646" mass="70380" checksum="4718FCD89A2F15A1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK89</accession>
    <name>A0ABR3VK89_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051861">
        <property type="entry name" value="NET_actin-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32258:SF28">
        <property type="entry name" value="PROTEIN NETWORKED 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32258">
        <property type="entry name" value="PROTEIN NETWORKED 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="48"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="730"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="619"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="786"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="962" mass="106255" checksum="C31717799316D3EE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKG3</accession>
    <name>A0ABR3VKG3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        </submittedName>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Tsang A."/>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="133"/>
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            <end position="371"/>
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        <location>
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            <end position="339"/>
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            <end position="451"/>
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        </source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="594" mass="62554" checksum="4C48F8C28DD97182" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM89</accession>
    <name>A0ABR3VM89_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ams2/SPT21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1231"/>
        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
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            <end position="566"/>
        </location>
    </feature>
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        <location>
            <begin position="650"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="717"/>
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    </feature>
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        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="949"/>
        </location>
    </feature>
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        <location>
            <begin position="1001"/>
            <end position="1011"/>
        </location>
    </feature>
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        <location>
            <begin position="1030"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1248" mass="135521" checksum="13119F16C0091B32" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN83</accession>
    <name>A0ABR3VN83_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="413" mass="45841" checksum="05873D5425F7E6E0" modified="2025-10-08" version="1">MADTQTPAPRWRGVGFPNHGADDQGWKLYITSLVMIISAGLFVIARIATRLVRNSLGWDDWTIVFSLSIYPFPQANSIVLSVAIQLAVSWGYGMHKADLTKAELETCLRWFFIAQTPYKVVVFLNKVSVVLLYMRIFVGNSFRIAAYAVLFVIFGYSIGGIAATIWQCVPIEGAWNKAVPAKCIDSNSFWVAYAVLNILTDVMVLALPVVPVMKLQLRWRERFLILGVFLLGAFVTITSILRVTSVQNSLKNRQDQTWSFIERGVWTLIESNLGIICACLPVLKQPLGKLFPRLFGSTLRGHSGVSSEGKYRHTDDSRGAHPNNSSTPTLSKVQGSSNPRFWRAPLKHQLSVSVSANRDTMRRGSDEHRIIGGNSDTGSDNIELGDRAAAAAEKGKISKTVELTRTSFHEARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN96</accession>
    <name>A0ABR3VN96_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="242" mass="28306" checksum="FEA1A9F89972A22F" modified="2025-10-08" version="1">MSPGLPHLYFARRVYFEDDIPQGTTIHFHRTRGGSHARSCSVDRVHSIWDDHFTTAASATSAATTGDMPRRDGVFGREAYDQLVRENEYMRLQLRELQDTRDRAAQLHRDNMALQNEIVKLRRQAVISAPVIDEDSSRREAKLKRKNTRLEEEVEDLRAQVDQLKTEAAEWRRKYDKLADKHEGVKEKLRKTENDTAAAARLATVYRQNLGAFEQQKRELEEENAALKRERNFDDLLRRRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNS8</accession>
    <name>A0ABR3VNS8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial distribution and morphology protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7685" checksum="68233696508BB0BD" modified="2025-10-08" version="1">MSQSLAPECNEVKERYDTCFLKWYSEKYLRGLGTTDNNECAGLFKEYSKCLQVNSLHFAQGRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP47</accession>
    <name>A0ABR3VP47_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="138"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="384" mass="41041" checksum="C51617D9B8AFFE34" modified="2025-10-08" version="1">MPRPVARGHVAPALTRPSPSNSRRLPPTTRTRTPTSWTVLLAIAVCFVSHALAVVAEPRAVVPDHRQPFLIGGRLALLSPVKRRADDIESSSSSESPKPTSTSSGSSSSASVTTTFSIGVTSTKPASTSTTAASASPLPSILDSLFSDFTPDPNGGEPPCQKFINSFLQDPTFKQCYPLSMLLDLSQSFFEAQRSMVSITRTLDATCAANPTTCNDYFSQLAAEFLLPENCGVDHDRRLQLVLDTHKALRAYAPVYSAGCLRDPDTGAYCYANAVTNASNPSSTYIYFLPLNRTLPGTTVPECNYCLKQTMALYQAATADRRQYIANTYTGAAEQINTICGLGFVNESLAAEVIPSSAVPRVVPAIGGVLMWVMVAAVGWAVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPI2</accession>
    <name>A0ABR3VPI2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_106</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12075" checksum="8C668F2B8AFA0816" modified="2025-10-08" version="1">MSSPRAESPKPASGGASTTGASPAPLRPSSPPPPGGPRTAIRRRAAQDQKEKIANARPNSTRAAGAGGSSSTMLRLYTDESPGLKVDPVVVLVLSLVFIFSVVALHIIAKITRKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPJ4</accession>
    <name>A0ABR3VPJ4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="272" mass="28165" checksum="F5EC967F99036913" modified="2025-10-08" version="1">MRVDTLNGLWGFCPTTVIAAADCGLAGSCVDSFSCSGGCGFTDQPLTTFTCSSGSDAAFCSTALLRFPDSPGAFTYLACGRGPITEEYLAFTTETSSSSKTQSSVSTATSTTEDRTATPGPTLASPSRTEDAVPTSTDTNNDTSQSQSSSAPINIGAIVGGVIGCVALICGCIIVLYWLRQRGRKAAAASGGSRPAEDATTPSANLFAVEVPGDKPRYDYQAFPFRPEDYNGVGVRPNGMAELSARSPVVHQPQLAEFPITIAPVELPSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPR8</accession>
    <name>A0ABR3VPR8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="344" mass="38283" checksum="7AFD3DF28DD768D7" modified="2025-10-08" version="1">MKPLSPWFERFLDDLEANEELPPSSPQLPRLPEFEPPKQTTPPLPPLPDLPSSPYSPPPARPDFYGFHTNHLAPPHAASSTITRPPSTHPTTPTCQPSPASFFAAAEEEGLPPKTARQLERCLQEVGDNLYARHILWKDEMESRMEKRVHQRVAEELRVHTSKFVLQSIEEPDGQGHQPSRESMELAYINESIGGDSDDSNDETYTPSVRSSASSSTEHGGDTRDNVINDPYNLTDSDDSDVNMEDAPAPRSGKHHHQRFKQYPLRSPKKYKSHGPRSSSSSKTKTNLAPVTPGHTSSKPKVCIIDIKGVVVLEGGDPAEGEDWAWFWVWSTGSEGRLGDTLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPU5</accession>
    <name>A0ABR3VPU5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="73" mass="8147" checksum="440D13334597205F" modified="2025-10-08" version="1">MVHTTHSKGPTSRSNQLASLIRGPDEGSEGRERSEAFMEGRYRYRDNCYEPTHGPSRSAAADKPVPVRARPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQE9</accession>
    <name>A0ABR3VQE9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="6">
        <location>
            <begin position="501"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="676" mass="74110" checksum="5C5B7CF17AF62C67" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQG7</accession>
    <name>A0ABR3VQG7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein BNI4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="81860" checksum="12CED446D510802B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQS4</accession>
    <name>A0ABR3VQS4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Malate synthase</fullName>
            <ecNumber evidence="3 9">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 9"/>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="10">
        <location>
            <begin position="164"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="12">
        <location>
            <begin position="414"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1843919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="542" mass="61184" checksum="A28133C66CA6033E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR23</accession>
    <name>A0ABR3VR23_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="704" mass="78957" checksum="FE566E1E82B60CA0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR61</accession>
    <name>A0ABR3VR61_HUMIN</name>
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        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="45"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
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            <begin position="113"/>
            <end position="147"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
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            <begin position="190"/>
            <end position="200"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <end position="760"/>
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    </feature>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1844325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="91467" checksum="310B40C1BF5FADDF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR81</accession>
    <name>A0ABR3VR81_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid metabolism enzyme regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="985" mass="105399" checksum="06E64742E19E72EA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRB6</accession>
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        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
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                <person name="Lipzen A."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Henrissat B."/>
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                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="SAM"/>
    </dbReference>
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        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="117"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="117"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1844303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="515" mass="57123" checksum="B6C05B1381D1915A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V177</accession>
    <name>A0ABR3V177_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000616">
        <property type="protein sequence ID" value="KAL1835534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TEA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="914"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="980" mass="106708" checksum="802903DB54EE143F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2I4</accession>
    <name>A0ABR3V2I4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000509">
        <property type="protein sequence ID" value="KAL1835914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="340" mass="37638" checksum="2E8069D8E832C6CE" modified="2025-10-08" version="1">MFAQKNNLDTHRRCHTGETPYVSAHPSGFHQFLSLTWCQVCPYCSRRFTQSVNLKSHINRHTGARPYKCPQCPKRFPQPSNVKAHMKTHVRRELRAHWVCRFPGCQKAFTAKGNLKNHQNTYHVEAIEAFNAKLAAMEDKSLLSEEEKEMAKYLAEVHNLANKGIKGRGKGRKVKRVMMLHPPQPPSPSPSPVSAASPLDTSPYPVSLVSHGLPHHHHHHLSHHHQHNIPPLPQTSAPHGQHGGLPFYGGGLSNPAAYSMSRPPLPPPPPPAGMLYDGGASLGVHTTTTPRDAYTHHHGGFAMLDSDTLSDASSVHGSTPVMPVYEDDHGRVLAFGERLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2P4</accession>
    <name>A0ABR3V2P4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000474">
        <property type="protein sequence ID" value="KAL1836048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF7">
        <property type="entry name" value="PALI-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="306" mass="31547" checksum="73AEED75091037A8" modified="2025-10-08" version="1">MATTRGVAGVFFQHAGTFLLFAATLLLVITCVSSPVTHDIALLRVELNDTGTRAWGVGRERVVSFGTFGWCELGFDGNGTDICSRPQVGYSPCSILSAPSNLTHNLTLPLPNPWGSSPVIAFSDDVRKTTDGLTRGMILHPIACGLCFLAFLLCLYAGTAGLKHPRGADARLVRFLSVLTALAALVATLLACILDFVLWSLVKRVVDGYDGPDEDEERKTTEVTGTGTYGAGAWTLLIAALCTAAAGVVLVGSCCCCRGRGGGGGEEAEEKGGGGAGEEVGGRGGGGTTYTTIQIGGGNVAEGNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3I7</accession>
    <name>A0ABR3V3I7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000429">
        <property type="protein sequence ID" value="KAL1836325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046302951" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="370" mass="40196" checksum="FE07543555C04190" modified="2025-10-08" version="1">MVLPSLLVLLSACGGSMAAAVARSTTPRARDGTCTTILQRRAWHTFTDEEKRAYIDAELCLMAKPATLGLKGTKNRFEELQWTHQHQSNIVHNVGAFLPYHRLLMWAHEKLLREECGYQGAQPYWDEARDAGKFSTSDVLDPVTGFGGNGVGERGCIVDGPFVNFTNSLGPGYRIGEDHCIYRFVNDNISRQAARSFIDECYRHTTFARFWPCAEGSPHSGGHGGVGGKMLDPISSPGDPVFYLHHTWLDKVWWDWQALDLPARLTDISGRNTPGGGGFGGFPGGGNGTNPGFPWGNGTFPGGPGGGNPWRNVPFQDMVPPADAPGPEGDPGNVTTLTHILKMYGVVPDATIADVMDVRGSLLCYEYVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3R7</accession>
    <name>A0ABR3V3R7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000415">
        <property type="protein sequence ID" value="KAL1836407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="157" mass="17849" checksum="C7F5742ED3985DD1" modified="2025-10-08" version="1">MDDRQSLLRSCDSPTAQHRRTQHWGREEQLMKVIYHPFTTDLRRSELEPLTVLHPTLDLLFPARLLASPLARAEPRLQDPLVDAQESLHCSTTLQPHPCKPRRSEASPSLTHSVSFSLRPRSACVLEAPSRSVHLSSSQMAGVFDIRLWSDRTTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3Y8</accession>
    <name>A0ABR3V3Y8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000414">
        <property type="protein sequence ID" value="KAL1836421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="432" mass="48658" checksum="0F8A48E45786FCAF" modified="2025-10-08" version="1">MKSDQSPVTVADYTVQAVMIAILHAVFTADDFVGEENAQDLKEQGGPGLTKLVLGFFHKAMGKDPRTENEKKDIETLYYTINLGSKNPPAFGKSTKEFEFDPNKRYWVMDPIDGTSEFKKKKGENGQYAISLSLLCRGQVLVAVTAAPNLSFKKATQELSPGSRGWESSQETEPLGIMVSAVYGVHGARLWQVTREGLKNGMHVKSTRPPPPLDERIFYNYRLSINNEFDRLSSQGGSSSLRAIFPHLVFLDSPSSKRTDSAWVNWLAGGKYWDRNIIYASLMRYLEAAIRPRNCFQIRMPKPELKGQHWDTWDHIGTTFIYEQCGGLVTDLLGRPLVFKGTKLRDTWGIIAADPEIHPYLVLAVWDAFLHDQQTQRYFPWGVNHLDLIHHLKNSPYIGRLNALKFGEIELGTRIVARFAAGATAPRARLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V469</accession>
    <name>A0ABR3V469_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000394">
        <property type="protein sequence ID" value="KAL1836578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49736" checksum="08A67D9989E92A12" modified="2025-10-08" version="1">MAASRKSRASGPPPPSTTLVLDNGADTIKAGFVTADKTDTPRIIPNCLARDRHKKIYVGSELDKCRDFGEIAFRRPVEKGYIVNWEAQKEIWDREFFDDKAPQPCDPSETRLVLTEQPNSLPALQTHCDQMVFEEFGFASYYRGIGPAFNAYRDIQSIFHTPRNPNTPISIPAEVLLLIDSGYSHTTVTPLLQGRPLHPAIRRLDVGGRLLTNYLTRLLSLRHFDMRSETYIANEMKESVCYVSLDFAGDLEKTWKGTRGERRDDYLSGAGIARDYVLPDSHTTFHGVVREYQPGVSGRAARKAGVSTEDVLTLRNERFAVPELLFSPSDIGIREPGLADVVMQSLATLPVGLWPGLLANIVVVGGNARLENFIQRLQMELLQRVPDECVVRVARPEDPVVSTWLGAANFARHEHVERLAVTKQEYDEYGAGWVARKFAAGLGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V499</accession>
    <name>A0ABR3V499_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMA20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000395">
        <property type="protein sequence ID" value="KAL1836574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-PUA" evidence="4">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="235" mass="25408" checksum="622F2259ADF57AE6" modified="2025-10-08" version="1">MFKKDLHGGPKQKLKSSVQRSIRQSLLTTYPLLTPHIDEVLPKKHSVEQIKLPDRASLYVIDGQPIAYQLDGGVLLPHLRLVHRFPQCFPTIRIDRGAIRFVLSGATLMAPGLTSKGGRLPVPVDRDAAAAAAAAAGGGEVKAEEEKKEEAGEGEGSDDEEETVKIPNEGPDEDGHWSRELEKGEPVVIMAEGKVEAAAVGILTMGTKDIKEKSKGPVLEASHYLGDGLWRLNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4P8</accession>
    <name>A0ABR3V4P8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000392">
        <property type="protein sequence ID" value="KAL1836590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27709" checksum="AD3C9D4A2E7EDC60" modified="2025-10-08" version="1">MRERRESQNLARIKNRTPPSPSPTGCSFPLLSRTRAQRPATFLPNTQEKNHSSLFFCSSLALALPTRFPLGLPALLIRQFLPLSLHRSALACFLSLRSKESHTPPEEKSKAVQTRCLLDGSCSRQHTTLNNNTNPGFPLFPCHRDRDTREPPLSHLEHLSLLIFHPEPCLDTPTKSTPPRGILHCFHLSPGRSLCFFAFSLLSCCAQILSFSFVLFSVFFSFSWTHHLSEETPGEPTTTLVRGHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4R2</accession>
    <name>A0ABR3V4R2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000369">
        <property type="protein sequence ID" value="KAL1836759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="317" mass="34886" checksum="E3A9EAD38DA0517C" modified="2025-10-08" version="1">MPRSDATSYSWYTMPSDYSDPLGLGDDRKCQVADCLKKHAFRRHGNRKVYSRYCADHTCAVMYPEEEGTHCPTPRNPTERYCPGHLRCGEPTCRKMGEYVHKSGEYIRWYCTKHRCSAHDCTARATDSTQKVCAAHLMRCSIPSCSRPAHRHRDGHLDVVCAAHYGTHRCLATGCDRWASARYCAEHRCLVSSCTASRASSPPNAEACLNHLCRAMGCANAVLYPTRNSSAHCALHTCRSPSCSAPRMTESGSDFCASHTCNTPGCRSEVVHSPARYCVRHACVVMGCTNARLSAPTSASGGNSPLLLAPGEDRDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V574</accession>
    <name>A0ABR3V574_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5136</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000409">
        <property type="protein sequence ID" value="KAL1836448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046814980" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="717"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1836448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="816" mass="87655" checksum="9ACE83F226DB45E3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5D8</accession>
    <name>A0ABR3V5D8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000344">
        <property type="protein sequence ID" value="KAL1836968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="361" mass="39912" checksum="58C4A539A3F75C8D" modified="2025-10-08" version="1">MAPTTSFHHMVGARQGLLDPTNVPLAGLVTGMVLSMLSISVLSAFTVQRYLAVKNWRRLPFVQWLVFCIYSDSFLFVLGTAIIQFGFGVGYSGSICETAILLCLVFYVTTKLIYLFMVEKAYIIRSDRAKPRLKSKPYRFNAFGMIGVFCVIIVLNFVMRFARIENGECIIGLKRQAILPLIIFDLLVNVYLTILFLRPLYSIYAFKTYGRSPGSNRLKTMALRTFIGCVCTLTSSIVNLSVLVALNGEPGWVCLMCCNSDILFSAVVIHWITSRDNATDNGTVSTASSQNHGRKGGPGTSGGAVMGGGDELHVISPRSTTHYRAREDDENDLLDDDFDTFSMGSKTKQQTARSTTTMARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5G5</accession>
    <name>A0ABR3V5G5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000377">
        <property type="protein sequence ID" value="KAL1836696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="457" mass="49111" checksum="5EF8C77B37118B99" modified="2025-10-08" version="1">MAFRTSLRLAATAAARRPASLAAARFYSQATTTTTTTTTVPNPDPTEDSPSAKLVRSHAPFMVATYSRPPPVFIMGQGSYLWDVDSRRYLDFTAGIAVNSLGHCDPETTRVLTEQAATLVHASNLYYNPWTGALSKLLVEKTRASGGMHDAAAAFICNSGSEANEAGIKFARKAAKVADPSGEKYEVVSFKNGFHGRTMGSLSATPNPKYQAPFAPMVPGFRVGELNDVSALPELVTEKTCSVIVEPIQGEGGVRVATDDFLVALAKRCREVGAVLHYDEIQCGLSRTGEFWAHSHLPKEAHPDILTTAKALGNGFPIGATIVNDKVAEKIKVGDHGTTFGGNPLACRVAVSVVERLADAGLQRGVKEKEKVFREGFERIKQKFPDLVTEVRGRGLILGLQLTEDPGKIVTAARERGLLVITAGENTLRFVPSLVMSEEEIKEGLGILEKAMEATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5M1</accession>
    <name>A0ABR3V5M1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="11">ETF-QO</shortName>
            <ecNumber evidence="11">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4323</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000334">
        <property type="protein sequence ID" value="KAL1837054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="10 11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="ETF-QO/FixC ubiquinone-binding" evidence="14">
        <location>
            <begin position="305"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="ETF-QO/FixX C-terminal" evidence="13">
        <location>
            <begin position="551"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="ETF-QO/FixX C-terminal" evidence="13">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1837054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="638" mass="70179" checksum="3D0FCBE731101C7B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5U5</accession>
    <name>A0ABR3V5U5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000366">
        <property type="protein sequence ID" value="KAL1836791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF6">
        <property type="entry name" value="BIOSYNTHESIS ACETYLASE ACEI, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="2">
        <location>
            <begin position="258"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="450" mass="51093" checksum="925E29011F6AB326" modified="2025-10-08" version="1">MASNYPPLKLPHPFLTSYHVRAVDSSTPARLVLTLDEKQPANGRPLPSPLHLDSLTWLDLKKPSPEECPPLNDNSPYARARRSPSTIIAWTGSSAPALGPVWNVVHAIYLAHPAHEYFRVKLDGTGKEILRDTLFATGLAIPHPAPRWDAKPPPPWTQEKPVPSGEDEILILRSSFWQGAASPVGPRPIWVVGDGTDSHLLAPLANYPLMPENYHITNKFPDGEPVFTRHPIRRPKPRPGSIVYSRYIPELDAHFSLEVVDWQDEEHLKLFNKWQNDPRVAAGWNETGTLDQHREYLRKLHFDPHVLCLFGRFDDARFAYYELYWAKEDHFGAHYAASDYDRGRHSLVGDASFRGAKRVNAWYSSCIHYCFLDEPRTARVVGEPKATGATILSYENAQGLVIGKYVDLGHKRSVLSICEREKWFQLCPIFWDGRERPLESADRAAWNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5X1</accession>
    <name>A0ABR3V5X1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000322">
        <property type="protein sequence ID" value="KAL1837162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="222" mass="25337" checksum="8A4F6942CF711C90" modified="2025-10-08" version="1">MEPQTVILTGPENWEAWDHEFRRFAAMKGVLDLIDPESPRFRRYTEQPKKPNIADYPKRLEGEPRTESTANGSEEELVDPINKAENVSELTKSGRELFNRDWDVYRANVNKYGCERYGRDVVAMWVINHVAMPLKASLSMDSYDAALWYRGLKIVIGEEARDLNRRAARARQRDMDVVTPLEGREARSRVPLTTLLTLGSSASLWVLIFSSLLDLLLVVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V664</accession>
    <name>A0ABR3V664_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4099</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000315">
        <property type="protein sequence ID" value="KAL1837240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="14">
        <location>
            <begin position="94"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="12">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="12">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1837240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1097" mass="120498" checksum="A45CC87E58E2AA71" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V721</accession>
    <name>A0ABR3V721_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000281">
        <property type="protein sequence ID" value="KAL1837579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF361">
        <property type="entry name" value="TRANSCRIPTION FACTOR SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="363"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="588"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="590"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="699" mass="75586" checksum="8BAF4AB16C5D4BB1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V742</accession>
    <name>A0ABR3V742_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000293">
        <property type="protein sequence ID" value="KAL1837445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="623" mass="68576" checksum="77A1E37FA77ED104" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V750</accession>
    <name>A0ABR3V750_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000278">
        <property type="protein sequence ID" value="KAL1837609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="229"/>
            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="321" mass="33581" checksum="14D464E80C0D0971" modified="2025-10-08" version="1">MALLGLSLIFGAVVLFCMRRPAWLSSLFAGAAPPAIEPPPAKQTKGADDASGHVPLPEIRHTDTGLSPSSPRPSEDGQATPKASATPRDPTPPVPVPAFSLSPADNTPDTTDAKPSPSPSASTLMPPPPRPPTLRPTSTSSSTTTTTTTSATSTLRNRNPLPARGPGCSTLAPPPTATAATTLNTPNNTSKSSSSRTIVLKPGHSPLDWARLTASPTADLRGLPPGTPYLRVTPSMLKRMTGRRGKDAWTVLGGKVYNITPYLPFHPGGEPELLRAAGRDGTRLFGEVHPWVNWEGMLAACLVGIYVPEEEGEGGEMEAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7D6</accession>
    <name>A0ABR3V7D6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000270">
        <property type="protein sequence ID" value="KAL1837703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37177" checksum="9848C75BE0757B1C" modified="2025-10-08" version="1">MEPSRGMIAFAPPDADADNGRKIDPINTEPVPETTTSTVANTNTSISLNHPASLPIQIPTTNAIPSSTNTTTTQTTQPRPTPKPRPSPALTTNPSPANNNTNDSNNNTNDNKRPKQAPTLRTAARRHPHPSAASARKPGETPARQRARANHNRVEKQYRHRLQARFEALLEVLPLQEEEEEEEEEEDASLGMWQTGSDSLSNTGTNCGGGCGGGKMGKRKARTGTPRDDKGLAAAHHQAFADGSSSSSKTSRRKQADGNSHGEDGVSVTKNSQQKDCRRQQQQQQQWQQPRRMSKEGVLLQAERTIRKMQEYIRRMDREMEVLRRERDEALRMARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7F9</accession>
    <name>A0ABR3V7F9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000271">
        <property type="protein sequence ID" value="KAL1837694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="61"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="575" mass="63813" checksum="50AA44B48E70762A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7M0</accession>
    <name>A0ABR3V7M0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000265">
        <property type="protein sequence ID" value="KAL1837754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="297" mass="33123" checksum="396659778A5BEC6B" modified="2025-10-08" version="1">MMSLRTIARAAPRILARASATPLPRFARTGLVAARPSLLRAQPASAFSTSLLRKNSAKSEVDEEVSVKLANEIEFENDVQSNEPLPASIKDFLDNGIWKVDDVPGKEDVTLSRTYGNEKITVSFSIADLQNFEPDLSEEDNAFGDELEEFESSSQQQQQQQQRSNAELEQEANEFDEEPSGTVPCRLNVVIEKPGKGALNVEAIAQDGTIVVENLYYYKDARLAHSTDAEAVHQAHDAYPGPPFGSLDEDLQILMERYLEERGITSALAVFVPDYMDYKEQKEYVAWLKNVKDFVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7P0</accession>
    <name>A0ABR3V7P0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000264">
        <property type="protein sequence ID" value="KAL1837770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF11">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="12"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="384" mass="40860" checksum="4DAD2B30B6299209" modified="2025-10-08" version="1">MSRRTTALVVPELNGKFELREVCLAEIQPDEVLVEIHASGLCHTDLSFATGVLPCQPGAVLGHEGAGVVLETGSAVTHVTPGDKVLLSFTHCETCAPCKSGHPAYCHDFNPRNMNGRRPDGSASMYTTSSKNSSTTEEKTPLFSSFFGQSSFARHTLVHRSSVVRVPADADLGLYAPLGCGMQTGAGAVLKSLGVREGSSVAVFGAGSVGMASIMAAAHVARAKVVIAVDVQPARLELARKLGATHTVLASREPGAKSTVEQIREICPPLGVDYAVDCTGVPGVIRDMVDSLGTKGRASTVGAPGFGKEVSIDVMQHLTYGKEYVGCCEGDSLPSEFIPYLMDLHAKGQFPMEEFIEYYDFEDYEKAIEDIHAGKVIKAVLKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7R6</accession>
    <name>A0ABR3V7R6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3386</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000262">
        <property type="protein sequence ID" value="KAL1837799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="87"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1057"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="826"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="920"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1837799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1241" mass="138319" checksum="9A8B86DC9C3D5BCD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V847</accession>
    <name>A0ABR3V847_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000267">
        <property type="protein sequence ID" value="KAL1837737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045909894" evidence="2">
        <location>
            <begin position="33"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="266" mass="28164" checksum="7751B64B2F3DCE2C" modified="2025-10-08" version="1">MQSSPIKCTFSRFTIAYILVLLLLLASTPVAADDQFSQPRNAPDSIYKAFALGISAVSSFGAGITAYLLESNDNASTQTPAVLLYVNMALKGTSAVCLLMLSAGYSLWFLRSRPNKARDFVIGAAVCVLVLVIMSREGSEANAATWLDKTNIIGFISVMMGILNAESGLLSALFCARKDEEGDDMHDRDSISLDAMEPNINGNFRVPSARALPPATMSGGSLPSTAPARGHILGEAPNAARPNLVLVFFSFIADLLSVAGAVNDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V898</accession>
    <name>A0ABR3V898_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_3151</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000245">
        <property type="protein sequence ID" value="KAL1838003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="870"/>
            <end position="964"/>
        </location>
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            <begin position="208"/>
            <end position="229"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="967" mass="108614" checksum="DE630A1603386DD2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8B6</accession>
    <name>A0ABR3V8B6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1838059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="109" mass="11258" checksum="3E98F8DB140E6C33" modified="2025-10-08" version="1">MSDAHPQGGKLEAMAKEGTKVPGEAAKPNVVPSSQGQEQQSTIKGAGVGREEPRPTLDQPALDGSGMPEVISAAGGDLPEDVGQKYSRHGGKERGHHPTPHGGRNLPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8E0</accession>
    <name>A0ABR3V8E0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000269">
        <property type="protein sequence ID" value="KAL1837716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="59120" checksum="D1F5C76888883FFE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8F2</accession>
    <name>A0ABR3V8F2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000258">
        <property type="protein sequence ID" value="KAL1837842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="56205" checksum="A4079EE2F36E8ED3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8V1</accession>
    <name>A0ABR3V8V1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000236">
        <property type="protein sequence ID" value="KAL1838132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF3">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047522760" evidence="1">
        <location>
            <begin position="17"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="483" mass="54500" checksum="54E85F7ECB6510C1" modified="2025-10-08" version="1">MMAIIQALATITVVLATIVSCREVPVNKRLRAEMYGPGLVHERIMATKHRIWGEFLRQGAFNSSQYGSFGPKKDVVQCRHGFAALVPGDPKNTFRCKNLDLYDFKTHAQLGSASGMGASIWGWTSPEGREFVAIAQEDGTAFAEVTRRGKLVYLGRLPQYGTAPKSMWREIKGYKNYVLIGSEAVRHGIQIFDMSKLLNVNPQKPVKFTNDKDLTGWWMEGLPMGKSHNVLANEELNYGVATGFQPRDWSLKAGMVFFDLTDPSNPTMLGGTGVDGYVHDAQCIVYRGPDKKYYGRDICYGYDEDAFTIFDVTDKKNITIISSVSYEGFAYIHQGWVLDPMWQQYLITDDEYDEYNRTGLGHDGYPVSYIWDISSLENPKQTGYYKGLRKGIDHNQYVKDGYTYQSNYGLGLSILDLRSVPMDPTGRSIREVAYFDTRPEDDDLPGGGNLTFTGSWANYPYFNSGYILVNTLDRGVFVLKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V912</accession>
    <name>A0ABR3V912_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flap structure-specific endonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000231">
        <property type="protein sequence ID" value="KAL1838192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="109"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="536"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="686"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="96061" checksum="AE82BC83B1302E81" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9B2</accession>
    <name>A0ABR3V9B2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MtDNA inheritance protein Dml1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000235">
        <property type="protein sequence ID" value="KAL1838142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="7">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="7">
        <location>
            <begin position="188"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="63252" checksum="285EE74BD80BF41F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9I9</accession>
    <name>A0ABR3V9I9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047483377" evidence="2">
        <location>
            <begin position="18"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="371" mass="41035" checksum="4B637B39655FADBB" modified="2025-10-08" version="1">MRLSSFSYLLLIPGAVAWNHIKASELQERLQRGERTLVAYIHHQPQDKPSQLLEPIWTSLQSQPPVDETAIVSIECSLSLPDCLQADVASYPAIRLLLLPPSSQTTTPNATSNKPKQHRYRGPRTASSILAFLRRMTRQSSSGLPTPVTTENMTTFASTADDVVFLGRFGPSKGKEKATGLSGLLRKEYESAARRYRDRYTFGIMTVPTSGSTVTCQNNVEGVHLSLSAAEISRPGAVDEFVRRCAEEVIPALTRRNELSFYETGKSIVHFFPPTPDARAAYLAEMRPLAQKYAEYLHFVTTDPREFPGAAEMLGLSRSQGGLSVQNPNTGDVYPYRRREKISAASVEAFLGDIIQGNVHAWKPGEGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9M9</accession>
    <name>A0ABR3V9M9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="443" mass="48392" checksum="4EC47C88C1D813AD" modified="2025-10-08" version="1">MENARRSAFKSEPVSVKTERGVRIKEEFPPALSSIPAVKSELRQSLSAIPPAPSSVVKNEPTDDHRLPRAPDSQNQRNRSRHDRRRHYGSNHLTLKMHGYHIRAHYGKGKVDFVVTKTANDIKYLSWTRTKSDMFTKFRNAKFMIEQSGPSSGGFKPVPQKAQAQDLPGLEKKMEPSSESTKLEGAGQAYEYLAAGKLKGCKALITGGDSGIGRSVAVLFAREGADVSIAYLPAEQPDAEETKAMVEKEGRRCVLIPGDLCDYDTCKATVEKHAQEYDGVLHVLVNNASKQMMCKDLQEIDLQNVESTFKSNILGMIAVTKYALKYMKQGGSIINTTSTVAFRGTASMVDYAATKGAIVSFTKSLAAQLMPKGIRVNAVAPGPVHTPLQPASRPAEQMEKFGEKGGIGRVGQPSEIAPSFVFLASKDAELYYGQVLHAYPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAP6</accession>
    <name>A0ABR3VAP6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000192">
        <property type="protein sequence ID" value="KAL1838804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="299" mass="33039" checksum="5787C7129EBEBFE6" modified="2025-10-08" version="1">MTNLDHKHQSGIAPRTSLDSFHTTTTTTTTSSLQQPTPSQSTLSLADAESLAHLDPIPSYEESLSAPRPGPLQILGATWGGVTVTQDLRRLAAGQDELTLDMKTLWTVLTPDPAPCKIKVLTVLYRFDDDKGKRRDGDGAEEENDLNEIRLLCVPEDTNPSKVVISRRASMAFLGEDCEDGCSARSGSSSRGGKRRDPRVLHGRVGRAWRAGPQGEVDILAVLYGPQKIETPSVLSVLSNHFEGRWGQIRMTNAFFGTDPWPCKRKSWTVYFRFVGSKRVQVVTGWEDGALEIPWSRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAU0</accession>
    <name>A0ABR3VAU0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000184">
        <property type="protein sequence ID" value="KAL1838950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="63"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="180" mass="19906" checksum="CE93D8E6FDBBE3A6" modified="2025-10-08" version="1">MDYVEQRVAQAASNHEATTNTLLTPLNALLLTALLYATYTFLFRKPPPPQIPSEPPATVFRTFTPRTLLPYNGENNMPVYLAVRGRVFDVTRGRNFYGPGGPYSNFAGRDASRGLACGSFDEEMLTKDLDGPLDTLEDLGAGEMEALRGWEERFEEKYLVVGRLVAEGEADLVGEPGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAU9</accession>
    <name>A0ABR3VAU9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000190">
        <property type="protein sequence ID" value="KAL1838843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22573">
        <property type="entry name" value="RMP1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="2">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="416" mass="44819" checksum="F3BCF8267B414ADE" modified="2025-10-08" version="1">MTRPPDALSSSSSSLPPTAPIPSIPPPSQAKPIPMITKETLTTASEALAPALHLLERFHHRNRNQHRPCRWWAQADMLRRGVSKMLGEVEGLIRIMEEEEKRREMVGKIGKGKGKGKKGDGAKGGGDRGEKGVGVRGEDEGDNNGVVAKRAEYLRWKLGPGAYVAFSQLAADRQFAHLGLMLLGVLAQVDRALAPFAPSPPPGCVGDGDWMIGNASGVAEMIPATLLTTTAKSLTLPERRLPRRMDADMNMAMATDTDLGVPVSRDEIFLSSTTKPELLDNGTLVETSASTPIPTSSASLLSSSSAQPKRAESLPAVESTQPQSNLNKPNKPRVTTTAASTNTEHPELKHKPTNESSHEPEPDPKPKVKKKKKAAAAGGDEFDDIFGGLDNDDDRPKKKKKKWKKADEFDDIFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB14</accession>
    <name>A0ABR3VB14_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000206">
        <property type="protein sequence ID" value="KAL1838576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="4">
        <location>
            <begin position="101"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="408" mass="45560" checksum="3091CA3B542B3DBD" modified="2025-10-08" version="1">MAPGILVDEPQPAIAPVGALKRNDGLSRDLFPDGIRTSGQHPPLYDLLKPYSAFPKSITGPTVWQCSDFEGHPERWVHRFTANEIAELSSAADAFLASGIPLTGIAKELFPLPTLSHTLSTVRNDLLNGKGFILFKGFPTDQWTIEKTAAAYMGLGTHLGYPVSQNSQGHVLGHVKDVGDDPTQIHSVRIYRTAARQFFHADEADLVGLLCLHRAQEGGESDIVSVHHVWNVLQREHPDVAELLTKPIWYFDRKGEVSQGQDEWIRKAVVYLERDDKQDGAAPRVYAKWDPYFIKSLQRFWDAGVVPPLSDEQKRAAEILEQVCLREALHMILEVGDIQIVANSHLLHARTAYKDFAPPAPRRHLMRLWLSTPEDEGGWALPFPDSHEKKRGGVQVNDTPPRAPLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB16</accession>
    <name>A0ABR3VB16_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF423-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000191">
        <property type="protein sequence ID" value="KAL1838825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="12922" checksum="C42EFF8C569988B9" modified="2025-10-08" version="1">MSTIFWRTGAVFGAAAVGLGAFGAHGLKKHVSDPQKLANWSTAAQYQLVHSVALLVASNNPVAGALFTAGMTMFSGSLYALTLDTERFRFLGPVTPIGGLCLIGGWLALAFGKRGAGMRWPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB93</accession>
    <name>A0ABR3VB93_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000201">
        <property type="protein sequence ID" value="KAL1838651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="541" mass="58831" checksum="2CDC6786E3FD1FF6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC40</accession>
    <name>A0ABR3VC40_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000159">
        <property type="protein sequence ID" value="KAL1839408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="73"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="175" mass="19878" checksum="9C6CEACC42FCA933" modified="2025-10-08" version="1">MADQIETGLPPNWEVRHSQSKNLPYYFNSVEKVSRWEPPPGTDTEKLKIYMATYHSNVVPSRGPAVAQTDDRAGKIRCAHLLVKHRDSRRPSSWRENTITRSKEEALEIIKAYRQRIVSGEISLGELALTESDCSSARKRGDLGYFGKGDMQKEFEDASFALEGIYVLTDDTRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC41</accession>
    <name>A0ABR3VC41_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000170">
        <property type="protein sequence ID" value="KAL1839200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046895610" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="132"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="376" mass="40804" checksum="DA00DEDC4AD6C866" modified="2025-10-08" version="1">MVLLKSFVLASLAAAAAAKSAVLDLIPSNFDKVVLKSGKPTLVEFFAPWCGHCKNLAPVYEELAQAFEYAKDKVQIAKVDADAERELGKKYGVQGFPTLKFFDGKSDKPVEYNGGRDLESLSNFITEKTGVRPRKKQAPPSSVVILNDSNFKQQIGGDKHVLVAFTAPWCGHCKKLAPTWETLAENFQDETNIVIAKVDADAPNGKATASEYGVQGYPTIKFFAAGSTTPEDYKGGRSEEDFTKFLNDKTGTQRAPGGGVNAKAGTVKALDAIVKKFVAGTTKLADAATEAEKAAELLTDEAQNKAAQYYLRVFEKIGKSEGYAAKELARLEGILKKGGLARAKLDELTRKTNVLRKFAGEEEESDEESDNEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC89</accession>
    <name>A0ABR3VC89_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000168">
        <property type="protein sequence ID" value="KAL1839245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="172" mass="19555" checksum="BAF4CB23CEEC2730" modified="2025-10-08" version="1">MSEYKEADGREFATINFEWRSQCVVEGQSIHPEPRIGFAFMGNDPILRDGLIQRLQPRIQMFNVTDDADETPKLVGTDLVHLVHVIPEYIPLSEEENGQAEPRLPVAQEVHIMYPNLAVAKAGTYHLRVSLWLVPGEGRESVELWSETYASFDCIPEAERGERMDAMVEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCR7</accession>
    <name>A0ABR3VCR7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="489"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="556" mass="60276" checksum="61B7D76BA04743C3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE91</accession>
    <name>A0ABR3VE91_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000131">
        <property type="protein sequence ID" value="KAL1840013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="265" mass="28406" checksum="4CC3CAD4E1892B5C" modified="2025-10-08" version="1">MSTPPPTKAILFLGATGGVALSTLRRSLSAGYSCIALCRNPVTLTNLLSNNSSSSDENKTLPPNLTIIQGNAHSSDTLTSCLRHPSDPTRLVDTIVFSIGAKPTLRGMSDPHVCEKGMTALLEALRTLRQSDDNNNKPTGKPRLIAVSSTGLSTLGRDLPWAMVPMYKLLLGQAHRDKKAMEDLVVEAGKGGEVEWTIVRGSLYTDGPATEGKVRAGWEDPVAGTRGEVPIGYTISREDVGKWIFEKCVEGSGEEWVGRAAVLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEA8</accession>
    <name>A0ABR3VEA8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000142">
        <property type="protein sequence ID" value="KAL1839741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="351"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="500" mass="53898" checksum="65D296C070C7E9BC" modified="2025-10-08" version="1">MRGPRPLGVVIKLGTSSIVDEKTHEPLLSILTSIVETAVKLRKDGHKVVIVSSGAIGVGLRRMDVEKRPKHLSKLQALAAIGQCRLMSLWDSLFNHLRQPIAQILLTRNDIADRSRYLNAQRTFNELLDMGVIPIVNENDTLAVAEIKFGDNDTLSAITAAMVHADLLFLMTDVDCLYDKNPRTHPDAQPIEVVDDIGSLVADVSSAGSSLGTGGMSTKIVAARLATSAGVTTVITRSSNPGNIVKIVKHIQASRSPPSLATKANQESTTDQQQQQQQQQQQTGTESPSASTVLVPSSSTTSLRNLGTSTPVTGTPSRPEPKIPLHTRFLPSPYPVRDRYFWILHGLRPHGTLYIDKGAYKALLGKAGLLPVGVVDVEGVFAQHEAVSLCVVERKRRKPRTPKAEEDGSAAGEEACGDGGSGKLWEGEPVEVGRALSNYSSTEIARIKGRQSSEIEGILGYADSEYVAQRESISFFAGIRESRPATPVREALERLGDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEF8</accession>
    <name>A0ABR3VEF8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000128">
        <property type="protein sequence ID" value="KAL1840073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="292" mass="30905" checksum="0C2029F74AC99B15" modified="2025-10-08" version="1">MCDNGPDTPFCSPLSGTEVQTGETLETDILKVTWNPLFFSPTSDQPADEIFVQADFLLPSDNNSPPQHAGFTSTALDPGAGAFRWPVLDTLLPGNSTSATAVLSIAAPLPTISRNGSFIRIGRGTNRFPGPSVRILRTESNNNNNNLNPSNPSSSEQLDQLGPPPAPNPLAIALPIALGLLTAILMITFMMLKSRRPDLFARIFPNSGRKGGLPMVQQKGYGERQSWAQRTRRVGGRSVEIKVVTTDMEGARANAARMVGQPGFAEVGTVPGAGTGTVRFVGGVGGWPGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEH2</accession>
    <name>A0ABR3VEH2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="185" mass="21316" checksum="850230A6B7ADC180" modified="2025-10-08" version="1">MVREGEHPGGGAEVSGTTKIIGFLADLDVRYRQETHVVLKLTKPDFDIGNPLPEQQPWIVFFSFLLCLLSLGFGFWDGKRAMTSQLLANFPWRLEIDKGWGRNRIHHSDWTTRRQWREGRGLGRLRNWKVDAIDTTLPHLFPSSPPLSQRQQQHHSRARSAAHTFVDKNTKKKRTTTQNNPDDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VES3</accession>
    <name>A0ABR3VES3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000116">
        <property type="protein sequence ID" value="KAL1840354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="890"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1086"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1344"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="599"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1572" mass="172942" checksum="F5237F6A1B7A1025" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF12</accession>
    <name>A0ABR3VF12_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="444" mass="49188" checksum="33F4C403ACE5EB07" modified="2025-10-08" version="1">MFTCASCHKSFRAGRSALEEHCRATGHPLPFSCDTCTASFALKESCEQHMDAKGHRATSPSSLSGALIDTFSQPGRPRTPAASGIDPLKPSSGKSYAAVLAGRANSTHQESPDKHQPAATTGKSDRFAGNNMNIAGDNHKIPDSGNDGEDLFESDSDTSTGGDVSDLPKVPLSSLGDEDAYDDFYARVAARGGYDNSAEKDAWNGSGSNGDDALKSTGEDDAEKTFWCVGCWKRFDNLRECADHEAVVHNYCRPCERMFSNALDFATHLNSPAHQDATVPCPFCEVKFTTVAGVVHHIESTTCEVRPNLNDDEVYRMIRARDKFDVLTKAPRDGKMPRLTQEEVNEEESWTGHGYQCLLCGKEFKGVVALQQHMDSAVHRQHLYRCPSIWCCAEFKKFSAVVNHLESGTCKYMKPSQVERFVRDIFTRNRPLYRLRRRDTRGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFT3</accession>
    <name>A0ABR3VFT3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="161" mass="18566" checksum="E57D05163FCA07FC" modified="2025-10-08" version="1">MAAELTVQSERAFQKQPHINLVSKTKVKSARPGKGGRRWYKDVGLGFRTPKTAIEGQYIDKKCPFTGLVSIRGRILTGRVVSTKMHRTIIIRREYLHYIPKYNRYEKRHKNLAAHVSPAFRVEEGDWVTVGQCRPLSKTVRFNVLRVLPRTGKAVKKFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFX6</accession>
    <name>A0ABR3VFX6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mago nashi protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17825" checksum="6DF20ECBD41BC173" modified="2025-10-08" version="1">MSNLNEPFYLRYYSGHQGRFGHEFLEFDIRVVGDGRSATARYANNSNYRNDSLIRKEMYVSSLVVDEIKRIVKESEIMKEDDAKWPTKNKDGKQELEIRLGNDHISFETAKIGSINDVAESADPEGLRVFYYLIQDLKALVFSLISLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG25</accession>
    <name>A0ABR3VG25_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuc-1 negative regulatory protein preg</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000100">
        <property type="protein sequence ID" value="KAL1840762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41467" checksum="76AC8ECF564A5D78" modified="2025-10-08" version="1">MLGWDHVGEVAGHVDSYSQYLAWKSDEPNPHSARTTLTIPTIEKPTSTESNPTRYVAVDAAPKYPPMEPMDYATGAVTRPNDTRPEPAVTSSTSASSGGRPANPVPARGSKTPRTLAPSGPTQRLDPTAAAASPSKRRISQDPGSTTSAPADAASPNHAGLPKRPRPAEKPTKILPPRYEQCPVEDMVVLIAHMLGELIETNDSIALQSGRLTRFHSRTAPGISVLDYLHRLAKHATLTPPLLLSMVYYIDRLCALYPDFTINTLTVHRFLITAATVAAKGLSDAFWNNSTYARVGGVKVAELNVLELEFLRRVDWKIVPNPDVLVAYYQGLVERCPGYALEEQESGGDAEQDETDITDEDSDEVNEDEADEALQGSQSAGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGJ5</accession>
    <name>A0ABR3VGJ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1108" mass="123567" checksum="734E7DE14A3CF751" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGX3</accession>
    <name>A0ABR3VGX3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="519" mass="58079" checksum="0F2074A6614289F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH39</accession>
    <name>A0ABR3VH39_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000105">
        <property type="protein sequence ID" value="KAL1840618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF2">
        <property type="entry name" value="GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="436" mass="46821" checksum="E4E8CA687CB0C863" modified="2025-10-08" version="1">MKLDMKGGDGVWQTRPVAGAGTDASGPAHLHIPLAGDARGSSRSSSIMKITKSALLAFAAAASASPTKRQSPGACPSPVRLDASTNVWRQYTLHPNSFYRSEVELAVQQISDSSLASKAAKVADIGTFLWLDTIKNIERLEPALQDVPCDHIVGVVVYDLPGRDCAAKASNGELKVGELNRYKTEFIDKIAEILKRYPNTAFALVIEPDSLPNLVTNIDLTSCQQSASGYREGVAYALRQLNLPNVVMYLDAGHGGWLGWDSNLKPGAEELAAVYKSAGSPSQLRGIATNVAGWNAWDLSPGEFSDRSDAQWNSCQNEKLYVEKFGAALRSAGMPNHAIIDTGRNGVQGLRQEWGHWCNVNGAGFGIRPGANTGVELADAFVWVKPGGESDGTSDTSAVRYDEFCGKPDAFKPSPEAGAWHQAYFEMLVRNANPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH50</accession>
    <name>A0ABR3VH50_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="315"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="679" mass="76170" checksum="81386B39EC99E514" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHG8</accession>
    <name>A0ABR3VHG8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">DNA repair protein REV1</fullName>
            <ecNumber evidence="15">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_7234</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000080">
        <property type="protein sequence ID" value="KAL1841289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 15" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="355"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="191"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="729"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="862"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="921"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1050"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="862"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="934"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="951"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1841289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1201" mass="132158" checksum="F18CE03CEE91DF26" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHM0</accession>
    <name>A0ABR3VHM0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="329" mass="35536" checksum="9805F08372D30314" modified="2025-10-08" version="1">MADGGLSHNQLATILNVLVSIDRRLSRIESVLKIPNPNLHNANPALTTAANPSSQAPPPPAPRPSTSQPLPGNPQQPLSGPNNTTTITTTTTPIIPLEPPPEGFLITSRAHMQEELDAWTLPRGYSMRIAGAKVTGKRKVRWVCFRGGEARLQRRQSQSQNDAPEEGVGGEGKRRRKPTTDRASKKCGCPFRFEAVETARDSDVWVLHYPSSSSSSSTSGAADDPSGTAAAAYKTHNHGPSDASARDDPRARKLPPAVAAEVDGWLRAGWMVSRIQEELRARGFVNVLNTDLYNRKRLLRKVTEEQRQEVGQGGGGGLSRLGRGEGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHR7</accession>
    <name>A0ABR3VHR7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="378"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="741"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="899" mass="99959" checksum="7B1F6F651B6443B5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHT2</accession>
    <name>A0ABR3VHT2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000091">
        <property type="protein sequence ID" value="KAL1841001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="172"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="624" mass="67026" checksum="511346648FB28BB1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI13</accession>
    <name>A0ABR3VI13_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="698"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="738"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="858"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="945"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1020" mass="111947" checksum="E57D2AFE283D9025" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIB6</accession>
    <name>A0ABR3VIB6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045439985" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="36"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="347" mass="38384" checksum="8A7FFB2ED4FC2BC2" modified="2025-10-08" version="1">MLWLSLLSMPAAVQAQAFSLNMLRFGCSQLSIDRIDPLVEPGNIPSAHVHQIVGGNAFNVSMPMTDIAQLATCTTCSFDQDFSNYWTANLYFRARNGSFKRVPQMVNEVIGPANAGITVYYTAPGPRTVTAFKPGFRMFTGDVMRRTPTNLGNRVQSCYRCYDGPNFQGNTMAPCFDPQRDTEHFPTKPCPGGIRSSVIFPICWDGKNLDTPDHKSHVAHPVDGPASFALVSGQCPSSHPVKIPQVHYEIVWDTRQFNNRNEWPADGSQPFVLSTGDPTGYAQHGDYVFGWKDNTLQLAMDNSCFGATCRSLTTQDFSKANRCTVTPAVKEDNDGWFNELPGGHHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIC1</accession>
    <name>A0ABR3VIC1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="100" mass="10700" checksum="E0E35851A39C9E12" modified="2025-10-08" version="1">MAGHGNPAIDLRSVPRLATASVSRFEAHGPPLAGLPLKMRNISRNPREGAGPIEAMQMHAMEMRMGGKRATATCAKMLSLRGYTPSPESEDSDRGQDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIJ0</accession>
    <name>A0ABR3VIJ0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="464" mass="49776" checksum="D99D7C057D5B50C2" modified="2025-10-08" version="1">MSLVFALEDTEPEASTHDSRERRANSRQELMGAHRDRSPSDSGVSTTEGLLPTLRHAESPAYETASYTSSRPPSSRGLASPSYLSPSLTQTPTYLPTPLSQHQPPFPSLSDGAVASRTQWLEEGQAHPSGTPLLRVDPSDHRHGAPAPPPGLQSIGTDATMSAVAASYDPAFTMGPRSFSTWPVMASGSSLMPPDLQTYGSEASLSPPSGSRSGTASPPRIGLTPEQRELKRQRDQARHQSKLQARSRRAESASSSVYSAASTPLPDMTTTSPRMPVYTTAPTQLSLLTEPSAPHYLPSYSPTLPDQSQPSMYPSAYSQSYLPPEYGYPPSTSPNLSSQYGPLASDPSLNIYPGLPPLVPGPEMSGQVRVVHSRPKPQCWDHGCNGRQFSTFSNLLRHQREKSGQAAKATCPNCGAEFTRTTARNGHLLHDKCKRKNINKDNNNANSSGSATPVPAGNTSPTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIN7</accession>
    <name>A0ABR3VIN7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36393" checksum="626C352C82CB22D1" modified="2025-10-08" version="1">MADTPVTFLPLGAIIQSLNVGGINIVQGFNSQADYEAHNGPYYGETIGRVANRIKNAQLSNLNGGKTYTLAANNGPNNLHGGVVGWGKRVWQGPEPVGIKEIPGVENVEGGESVKFKIVSEDGDEGFPGTVEASVVYTVGKQKTPEGKEVVVLGIEYEAELVGGADETVINMTNHSYFNLTNGPSIEGTVVTLATNVYLPVDDGGIPTGGPTVFSKVPAGGQAFTLGAQEPDIDDCFVVNEAPSTVPIDTRGLPLTKLVTAHHPASGVHLEVLSTEPAFQFYTGKYIDVPAVGGLPARGARSGFCVEPSRYVNACNVDEWKGQMLLKKGEKYGCRIVYRAWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIP9</accession>
    <name>A0ABR3VIP9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6907</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="234"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="606" mass="67822" checksum="636E6EC4B2CFB986" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJB8</accession>
    <name>A0ABR3VJB8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF32">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="344" mass="37172" checksum="5BFE82AAAF462117" modified="2025-10-08" version="1">MADTLPPTPISVWAYNPSFPLAVLSTVLYCILFVTITYQTFVRYRTWYFTVMVVGTAMEVPAYALRCYSIKNPSNIAIYATSLSLTVLAPVLVAAGNYILLGRLVRQGPSVIPSSSSTTTTNHNPHHGDGARAGGAGAVICGLHGRFISRVFIVCDTVAFLVQCSGSAIATVNDWFGPQAQVGVWVLVGGLAFQLVAVMTFLGFLGRFQRIVGKAGILDGQAWGKVVWAVWVSSVLIVVRCIYRLVEFAEGIEGYSFTHEWVFYVFETVPVLIAIGVFCLWHPGAHLGPIDDKSLRSQRKRARLGSGVAEGGIEILVSVMMGERISAEPDTTLSVKPVVGNPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJH9</accession>
    <name>A0ABR3VJH9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="321" mass="35141" checksum="E9CFBE89896E8120" modified="2025-10-08" version="1">MYGQRHPQRPQQRSAYQPAASDRFRQPTMGAPSPSGTARAPAAMAQGTMGYHSAAPEYGQADSRQSQSFGGTYPQMMYNVQQTGGPQSGGVYDAGQPYSSRQAAGLPMMATDVTGPYFSGESGLHGYSAGSMQPAIGAMPAQTAAPDVRMEEGYAPATTALDESYAQYQSEVKGIFENIRNSNLTAASEALLRVSEWLLLHVVDLGLTTDNQSLHDERITLWNDFNHAWLALFQRQKEMMEAGLQTVQRPQTVVSQETLKKMGKELVRLCDNIERHGLVDYQYGVWEEQIVDILEECLDLYEAQQSSAAGGNEGASSSHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJI4</accession>
    <name>A0ABR3VJI4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046381986" description="Cytochrome c oxidase assembly protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10226" checksum="913AF569FA25773A" modified="2025-10-08" version="1">MSRASKLTLLSTSLFAVGTVAFVHWAQKADQQAMHQGVLRDLEQQRLKRERQADFDAQRALEAEYLKEQSVRESNLDEVPGLPSSKGAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJQ3</accession>
    <name>A0ABR3VJQ3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000053">
        <property type="protein sequence ID" value="KAL1842115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="462" mass="51987" checksum="E4A0A174A0235816" modified="2025-10-08" version="1">MALDLGTVLAVAELVQKALEIYRRIDDLPDQMAQIGRRMKQLNNVLVVFHEFIQSQEQNAKRTTAGSGKQSLLSGQLNDLREVFDDIKFTAKKVHDLFDRYENGILSRSLDLEFRKPLFARVWFAVFDNPADRAEALIREIDGYCTNLNVYLNLLNLKKAYKPRSKRPKTAVVRKPSPAKGSGSRPAAVPAPAAAAALSAGPSLNVTPASPPVRRDYKILFVDPYNIGRSVVAQALVSLLGRLTKRARGDWRLDAVQSSGFFVRRYGGCVKTIENLTYSHPTFRKPLFPGGERPKAAAMAAVFDNKWMNYSFKKEIRDEMTARTSRGLSRDIFSYYDFITVFTLREHDNMVRLKAALRKEEQSSGLGSRPVSDSGTVWHGGKGRVIQLGMYLARKKGELREIWGPRDTTDPVKEREQWNQKVSEIKVALKEFLRQEMEWTPPTGVDIEGPKPGNPSLQGSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJZ7</accession>
    <name>A0ABR3VJZ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucan 1, 4-alpha-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="82652" checksum="DE9C82EA0E40B49C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKC2</accession>
    <name>A0ABR3VKC2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MTHFR SAM-binding regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000051">
        <property type="protein sequence ID" value="KAL1842182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="303"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="634" mass="71425" checksum="F2CB9D2F63E0D04B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKH7</accession>
    <name>A0ABR3VKH7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="621"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="956" mass="106728" checksum="51289083D59EB52A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKM4</accession>
    <name>A0ABR3VKM4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000059">
        <property type="protein sequence ID" value="KAL1841930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="98718" checksum="50B04755E58BD498" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKN1</accession>
    <name>A0ABR3VKN1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047525597" evidence="3">
        <location>
            <begin position="29"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="651" mass="70449" checksum="23E1532325FB1A4E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKW8</accession>
    <name>A0ABR3VKW8_HUMIN</name>
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        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">VTJ49DRAFT_5350</name>
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        <name type="scientific">Humicola insolens</name>
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        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
    </dbReference>
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        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
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        <property type="entry name" value="H4"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="137"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="144" mass="15776" checksum="044387A895F30BA3" modified="2025-10-08" version="1">MDRFGVEAPPIHNTKVGHRVAGLPQRVPGLHAIDAHTSPTTTSSSHLGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRTVLKSFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL81</accession>
    <name>A0ABR3VL81_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">Histone deacetylation protein Rxt3</fullName>
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    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_5189</name>
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        <name type="scientific">Humicola insolens</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
            <begin position="1027"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
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        </location>
    </feature>
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        <location>
            <begin position="1192"/>
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        </location>
    </feature>
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        <location>
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            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1235" mass="134371" checksum="0E960B25699603BA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLF0</accession>
    <name>A0ABR3VLF0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="340" mass="37372" checksum="4532FE4500B67904" modified="2025-10-08" version="1">MGRAHHTKLLTAASAASYRKDNKKDCKPQAGQPQINDNIDNPNEPAGGYRVFFDLDSEHTDWFEKALEASGLQAHRVRVIYEQALEEKLRELGYSKDDLIKDKGAADLVFLEAVSLAALLCKAEEDNRAGMPSKDILYDNNSEAVGGPTTRSRSKRKVVHDSEDSKTNTAAQDGSAETRKSKGQGRRKRGCEDKGKGTMKNPGHSCKSLGMAPGHALEPHPEDAPESSAQQHDKPRIREFPCTMCTANALNGNLKGECMAVPGKTACTNCISDDLEVACQDVPPAIKSHVKEWFAATRTYDHAYAAMADAKTAMENKRNTVQELYRAIPDKKDKKMPQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLR2</accession>
    <name>A0ABR3VLR2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="5" type="ORF">VTJ49DRAFT_4002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="425" mass="45814" checksum="985B10DD9055402C" modified="2025-10-08" version="1">MTESKPGQVALTRPCVKCRAQEATLDSRSQPVCKDCFIKFISTKFIKQIDILGKKTRPAPGPSSTSSSSGPPTLTRRYLLGLSFGVSSTVLLHLLSENLESQLAKGRTAPFDLTVVHVDTSSFPSREGTDPEASVAAVEAILDRYRARYPRFTFQRVPLSSSTLSNNNNNNNNSTPNPSDDIFSLLSSSTTTTPPTAASQSDLRQHLTRRTLLAETAHHNCQALLLGHSTTALAELTLAEAAKGRGFALPWLVGDGPAPPPDSSSEPRESGLLIHHPLREALRKELVTYAGLVTDPSPLTDLLLEQTNDNPGSAEGTTRVVSHRDLSIEDVMTRYFAEVEESYPSVVANVARTAGKLVRRGGDGGDEEAATACELCGMPRDEDGDVRWKGELGIQDNGEEEGDRESVAARLRGRLCYGCERSVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM11</accession>
    <name>A0ABR3VM11_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4366</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="503" mass="57062" checksum="96CAAECE5CB1926C" modified="2025-10-08" version="1">MGEIYPSLSQCAVVTAALKILLFPAYKSTDFEVHRNWLAITNSLPLWEWYYEKTSEWTLDYPPFFAYFEWIMSQVAKLVDPAMLKVYNLDYDSWQTIYFQRFTVIITELLLVYALQMFVESSHGASKRAAQAAAISILLSPGLLIIDHIHFQYNGCMYGMLIASLVLARQKTTLLWSGLLFAALLCMKHIYLYLAPAYFVFLLRAYCLSPKSIFRIQFLNCIKLGAGILAIFGAAFGPFALKGQIPQILRRLFPFSRGLCHAYWAPNVWAMYSFVDRVLIVLAPRLGLPVKASALNSVTRGLVGDTSFAVLPDVTPRVCFALTLAFQAIPLLRLFFRKVVAWEDFIGAVTLCGYASFLFGWHVHEKAVLLVIIPFSLIALKDRRYLGAFRPLAVAGHVSLFPLLFTPAEFPVKTVYTLFWLLLFLMVFDRLAPASTRPRFFLFDRFSTLYITVSIPLIVYCSLVHGIVFGRSYEFLPLMFTSSYSAIGVVGSWVGFMVVYFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM86</accession>
    <name>A0ABR3VM86_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="607"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="879"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="962" mass="105235" checksum="9F30CC8AB5308066" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMU2</accession>
    <name>A0ABR3VMU2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="140"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="473" mass="52448" checksum="6A30CD7A9B9FB123" modified="2025-10-08" version="1">MTVSLGRVAAAGASHQLSKNPNSASAEQVPPTATPSEPSPQQYYFKDGLRRVAPYLYTYNTWCKERWRGRELLDIFQSEFRDRPIEYYREAMESGQVAVNGKTVGPHYILKNGDLISHTTHRHEPPVTAEPIAVIHEDDDMVVINKPSGVPVHPAGRYHYNSVVEIMKAERGPDFAPRPCNRLDRLTSGIMFVAKHAKAAERLAVQIKQRSVCKEYIARVVGKFPDGEVVCDQPILQISPKLGLNRVRANGKPARTVFKRLAYYPPKPAPNGRQNEESAKSNTTTADESDLTTQPRGSNGAGKGYSIVRCLPVTGRTHQIRVHLQFLGHPIQNDPIYANQRVWGFDLGYNDADGTQNSDEDIISRLSRIGKDQVAEAVAYHDAMVDEYYKKKAEKMSGEVCDVCGTPLYTDPGDQELCLWLHSLRYEDADGAWSYVSPLPSWALPPEGASGPTQVGSLEELVDAAGTFEVDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN22</accession>
    <name>A0ABR3VN22_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="690"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="868"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
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        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
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        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="892" mass="95851" checksum="22AA4A98887A5675" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNE4</accession>
    <name>A0ABR3VNE4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="487" mass="53228" checksum="5E00625A8FBE20CB" modified="2025-10-08" version="1">MPPSLFDYLVENEPAFRKTRLPALYSEFQTQRTIKPDAYQANVSAWRQALSRIVSSGLAPSPRGQDPSLFVLHSGEPLARALESKQYGRPLALGAVVQEALAARDLIPLREFLEAKESVYRRSWSVWNLASWTMKQLGVADYLKKDTLPPGDFVVLANVEEAGRAFSEHAKDATGAGTRFERTFTKAHFLRTFNSLLVDGKQLSKTDADVILRFLSRDKGAIAYDGATVRINPPDSAAEADDEPPSITPEDESMAQIKELLANLTHQAALLTDRIAQLTSQATLAAKQQNRTAALAALRSRKLAEATLARRLAAANQLEEVAASLEHACDNVRLARAMEASAAALESLHARTGGVERVEEVANTLREQMAAVDEVASILAESAGTVVVDEGEIDEELEAMEAEERKKREEEAERARAEEVRKRLAEAGEVPAALPAAGTAEEEKRKGDGELRFAEDLMSRLSLKDEGGCMRERTANRALRVASGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNG2</accession>
    <name>A0ABR3VNG2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="132" mass="14956" checksum="445B8A5D86FD71FE" modified="2025-10-08" version="1">MTVHNIKSLQEFKETIAKQPVVIIDAYATWCGPCKAIAPQIAKWAEDPQFKDKTYFAKFDVDEVPDLAQELGIRAMPTFIFFKNGEKVDDFMGANPPALLNLLKKHNPEEATAQKEEAKEEEAKEEEKKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP21</accession>
    <name>A0ABR3VP21_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="240" mass="26809" checksum="1D00A8664DC82425" modified="2025-10-08" version="1">MTDQFLAEQHTWILFRNSQSDEADSWVMLTRDGEIVPIPGEKILHTSRPRVGIDISTPRELNIANPFSLKCDNGIAYITNERVIYLPARPSEGFKSFFTPVLNFTDTHVHSSWIGPWSWGGTVRPVPGGGIPAHIPRVEVKFTFRDGGHSDFQTKFEWLKERLHHAQELGLAPGQNLEPPPPYEPGPVGSPTGGAGVGAHQQQQPPPPAPNEPPPDYEQAQSQAVTMRLEERMREEAERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP76</accession>
    <name>A0ABR3VP76_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="318"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54223" checksum="BD959D9676580277" modified="2025-10-08" version="1">MFEAAATSFASILVLGAGFALAAYGYHKGYKYMVLHKMSRAFEPGDPVLELAAIGKDLPPPKTAAATHWVERPEQAHVDDIVAGRVGGHYHLFIGEKGTGKSSMLLEAMRKIDGDGVAMFEAHADLEIFRIRLGKALDYEFHEDYIGGYFSERGPRDTTALLDIERALNKLEKVALRRRAKMGRPLVVIINQMHLIRDDDDGKDLIELLQQRAEQWAAANLVTMVFNSDDYWVYERLKQLATRMEVLTITDLPKAQATAALRNYRQRYFHEVPSSEILDQVYERVGGRLNFLNRVAKNKDMLAACDKIKEMEKTWFLNQCWILGEEMDDDVMDQQKWAAAAVVLATALVDKEKEMESTYDPVKGHILPSYPLYKAQEIMTRVDFVRAFDRLNLFSITSDAQVRASSVPMHLAFREIVAQPGFREHLQGTIDRIGAIESLGRTRELVAKDLVLGGKYEIRKVPGGVDVNLKQKEEEEGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPN7</accession>
    <name>A0ABR3VPN7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="419" mass="45172" checksum="6DA0E84ED8BB7F53" modified="2025-10-08" version="1">MRQMIPPSTSRALLHSGRPRSSAWAAAVSVAGNIVSNAVSRATKRDMPSIDPLRIVAKEMKFLTGNIRKLLGSGHPSLDRAAKYYTQAEGKHIRPLIVLLMSRATSLCPKAPHRQQATIQASAAIDTSISPLSILSDFNPSAGVESEPVSSDVDILPSQRRLAEITELIHTASLLHDDVIDHSVSRRGAPSANLEFGNKMAVLAGDFLLGRASVALARLRHAEVIELLATVIANLVEGEFMQLKNTARDETNPRWSEDTLTYYLQKTYLKTASLISKSCRAAALLGGADAQTVDAAYNYGKNLGLAFQLVDDMLDYTRSEAELGKPAGADLELGLATAPLLFAWKTIPELGALVGRKFSQEGDVSRARELVMQSDGIAQTRALAEDYADKAIAAISGFPDSEAKDGLVEMAVKTLQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQM6</accession>
    <name>A0ABR3VQM6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07406">
        <property type="entry name" value="MPP_CG11883_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041821">
        <property type="entry name" value="CG11883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="323"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="690"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="880" mass="97670" checksum="74DA4E804D9CA961" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQV7</accession>
    <name>A0ABR3VQV7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">arginine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_1136</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF8">
        <property type="entry name" value="CYTOCHROME P450 2E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="16">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="15">
        <location>
            <begin position="516"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="862"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1189"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1194"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1843543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1237" mass="140510" checksum="3C756CDD5E164BAB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQY1</accession>
    <name>A0ABR3VQY1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="443" mass="48058" checksum="B0A88731C8A509DD" modified="2025-10-08" version="1">MFLAALILASKYLQDRNYSARAWSKISGLDTLEINQNEMTFLLAVNWKLHVTEEVYKRWADCVSKFTPSQPPSPGAPGQQLYERQCYDFRRIILNLTPDLDNLDDLVPWTPVREQSPRSLYTPPGERSVPTTPDSKLPPATKPCSIPAVMEPAPSLSYGPGRLAPAFGFLPTPRLTPQLSGFSTPAASSASSLLGRSSSMGFAMAQVSASLAAHSMDRFWLASETSSPMSYVTRRSSLANSVSAASSPESMISDSSRVSRSSSLSSASSLPAPSSKSEVQARYRYAKLGGERLSVLPTIASVPEDHAEDYFTTSPESYVGPVGKELPLPLPACDVDDAARVLQDMHRSDDDRSVMSARAGSKRSRTNSVHDDVRDLLAGRFEDGPWPATLVRDRTQAQQVPVLRSSRKRVCCSAEAAIAPRIPSLQRAMGASSGQGMWSGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQZ6</accession>
    <name>A0ABR3VQZ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="916" mass="101065" checksum="843AA55C5DB20BD2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRC9</accession>
    <name>A0ABR3VRC9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1280"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="775"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1107"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1143"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1576" mass="170108" checksum="230A2534F95C81F1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRG5</accession>
    <name>A0ABR3VRG5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="42252" checksum="93CB23877B629F83" modified="2025-10-08" version="1">MAPPTEPLNLDVEAISGICGSISIACWVVVFSPQIIENFRRGSAEGLSIQFVVVWLLGDVFNILGAVLQGVLPTMIILAIYYTIADLVLLAQCFYYRGFTLSDDVPAPPPPPPPKTKKRNGSATINGNGAAAADERTTLLFNAGPAADAHYYSISDRERRGSWVSHLSPAVPFVNEDVDVAPPPPPPTWPQAVAFNSLAVLMVCAAGVAGWWLSRTYGRGSGSGSGEDTPEQPPPQAPIELSTMGQVFGWLCAALYLGSRLPQLLLNWRRKSTEGVSVLFFLFACLGNLTYVLSILAFEPRCEANGDEGCRPGEAARIYWKYMLVNLSWLAGSAGTLLLDLGIFVQFFMYSKGEEVCSSSSSSSSDVESGDEEEADPWDQRPVLERNNTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRK4</accession>
    <name>A0ABR3VRK4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055525">
        <property type="entry name" value="DUF7099"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055526">
        <property type="entry name" value="DUF7100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055527">
        <property type="entry name" value="DUF7101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23388">
        <property type="entry name" value="DUF7099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23391">
        <property type="entry name" value="DUF7100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23392">
        <property type="entry name" value="DUF7101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7100" evidence="3">
        <location>
            <begin position="7"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7101" evidence="4">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7099" evidence="2">
        <location>
            <begin position="483"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="894" mass="98721" checksum="41F881E69943B31D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRP7</accession>
    <name>A0ABR3VRP7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_13</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="151" mass="16622" checksum="6CB0FE56BE554B1C" modified="2025-10-08" version="1">MDASCQCGAVKFKTPTPKPLALYICHCQDCQRQASSAFGTSAIFPRFKLPDTELLSCYTRQTSLGDTLYCYFCKQCGTRLIHTSPNKNVVSVKGGCIEGLDWRTAIHIWTKSAMVPIPEGSETHSEYSERTDYMGADSQGEPLDQPGELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRQ3</accession>
    <name>A0ABR3VRQ3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_24</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="134" mass="15165" checksum="15FE8A9C9D42B56A" modified="2025-10-08" version="1">MALSQRLKTLRLLHTAIVTSWIGLGTWCMWCYLQPQCINPALSKYPIQYLTSTVGYGVIMWIMGPQQVAVFYLSFGVVAVCQVLMYFGFGVWPFRGIISLSAWFPPFAVNLLILCGCLWCAKLLRDDKAESKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRS5</accession>
    <name>A0ABR3VRS5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_53</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="181" mass="19539" checksum="76A9E3188923F0E6" modified="2025-10-08" version="1">MYASRLRTTAAATARHLSKRATTATAPFSTTARQLEIAQSPSPEQQATAAAAADAQTATAVTEGAAPPAVVNQAPNRVGIWSRSQRPRAEAMTGPRFEQTDFELQPRPYAAIELIHKQPVRWTHDRVVACDGGGGPTGHPKIYINTDKPEIATCGYCGLPFANEHHREHLESLPETSYPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0W6</accession>
    <name>A0ABR3V0W6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000683">
        <property type="protein sequence ID" value="KAL1835409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="189"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
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        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
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        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="517" mass="54554" checksum="BE33C6C287A1C978" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1H8</accession>
    <name>A0ABR3V1H8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000589">
        <property type="protein sequence ID" value="KAL1835617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="233"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="474" mass="53485" checksum="B77DEF027828709D" modified="2025-10-08" version="1">MVDIASRPRHIPNLVIQGEDGDRVLEPGHYGNGTAGVNTNNDSTSHVPAIPPHPLGIKPLGNKFLFACSMADDVWKTIFLESEMGKKHSFGWRGSWRATVLGLSPEQKIQIDCSNVFSDMLHRPFVCSHISLDHYAQNIPASNEIDRLPDLSYEEFAAKWSKKPFMLTQCIQSWPVTRSWTIDNLLSQHADVVFRAEAVDWSFRTYCQYMRDNQDESPLYLFDRKFAEKMGLSIGKEEGAAYWKPDCFGPDLFELLGSERPAHRWLIIGPRRSGSTFHKDPNATSAWNAVIQGAKYWIMFPPSVQVPGVYVSRDSSEVTSPLSIAEWLLEFHAEARRLPECREGICRAGEILHVPSGWWHLVVNLEDGIALTQNFVPEAHLGGVLSFLKDKPDQVSGFKADVADPYGLFVSRLRDQRPDLHEEGLRQLAEKKRRWDAVVGNGDVDDSEQPQKKSAGFTFGFGFGDDEEEEEEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1T4</accession>
    <name>A0ABR3V1T4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000554">
        <property type="protein sequence ID" value="KAL1835722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="184" mass="20526" checksum="FD6438F65C562D35" modified="2025-10-08" version="1">MCHGHPHTHSCGHQSVTWHYCPSAVIDLTTGYETPCQNITFAASQSSSASCPLANCDFQNAGGGGWTCCQCGGRNSSGWCNNMRPRYERNPFTGEWDWFELCDHGCCLNCIKDGELLLSVQFNESLLTSTFCDSSLGQLWGSQPQKREERERCSETSANPPSRRLRCSVQHYSGLWRQKKGLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2C6</accession>
    <name>A0ABR3V2C6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000524">
        <property type="protein sequence ID" value="KAL1835854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="488" mass="52801" checksum="F9256888520819C2" modified="2025-10-08" version="1">MTVTEPTPEQLAELKTKYEAAGQGQVFTFYDSLSSEEKAALYNQLAAFDPLYINTITAKALAPPADDPTQPSSLEPLPDSARASIMDSSPDDIARWYSQGLDLIAANKVGVVLMAGGQGTRLGSSAPKGCFDIGLPSSKSLFQIQAERIRKIEELAANKAGVPASNVSVPWYVMTSGPTRGPTEAFFKEKNYFGLRPENVFIFEQGVLPCISNDGKILLESRGRVAVAPDGNGGIYNALVDSGVLDDMKRRGVEHVHAYCVDNCLVRVADPVFIGFSAAAGVDIATKVVRKRNATESVGLIVAKNGRPAVVEYSEIDPAMAAEEEPGQPGVLRFRAANIVNHYYSFGFLATIPQWAKSLPHHVARKKIPYADLENGGETVKPTKPNGIKLEQFVFDVFPMLEMSKFACLEVRREDEFSPLKNARGTGEDDPDTSRKDILEQGLRWLKAAGAEVILAEDQPGVEVSPLLSYGGEGLEQYKGQTITSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2T3</accession>
    <name>A0ABR3V2T3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6351</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000595">
        <property type="protein sequence ID" value="KAL1835593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045169129" evidence="7">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1835593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="423" mass="47618" checksum="D80ACCA8F131A29B" modified="2025-10-08" version="1">MRLLRALLLGLLTLAQLALCTEDYYKVLGLNKDATEKQIKSAYRQLSKKYHPDKNPNDPTAHDKFVLVSEAYEALSDPESRRIYDQHGHDGLKQHKQQAGAGAGHHDPFDLFSRFFGGGGHFGNQPGQRRGPNVEVKVGIPLRDFYNGRVTEFQWNKQEICDVCAGTGAADKVVHSCPVCGGRGVRTVRQQLAPGMVTQVQMQCDACGGRGKAIKHRCKACNGERVVRRATTVTLNVQRGMADGARVSYENEADAHPDYVAGDLIVTVYEKEPVLESDEDNPDRVDGVFFRRRGNDLFWREVLSLREALLGDWTRNVTHLDGHIVRLGRPRGQVVQPGHVETVVGEGMPVWHEDGDDVYHKTEYGNLYVEYTVVLPDQMESGMEKELWQLFQKWRTRKGVDLHKDSGRPDKPVIKGEEEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V380</accession>
    <name>A0ABR3V380_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cap binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000471">
        <property type="protein sequence ID" value="KAL1836065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="331"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="538"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="93108" checksum="4AB01336DE5798E0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3F1</accession>
    <name>A0ABR3V3F1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000432">
        <property type="protein sequence ID" value="KAL1836303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="81" mass="9245" checksum="7600EE7B3127AF93" modified="2025-10-08" version="1">MILLRFWLSSVDMAYDGGEEHDPDQPAPGPIVTEFKYFLALQAEIRVDIYDLVLQHEPSLFPDIEFDTKQGATDCRSRATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3J4</accession>
    <name>A0ABR3V3J4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000455">
        <property type="protein sequence ID" value="KAL1836162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="236" mass="27269" checksum="0E114650B987EE87" modified="2025-10-08" version="1">MPARNRSHDHIVHCINEFCTTDLEPQLVLELVPFGSLKDQHEVSPVTLNEVFQILRQALSALRYLHERDEPIVHRDIKPGNILVQSRSPYLHIKLSDFGLSRASPDYLKTWCGTSSYAAPEVIERENYDKAVDIWSLGVVVYEYAHGLPNRNYWLCDGSPWIERVLQELEAATDFWGCPLLDFLSTAMLVYDRVSRYSARRCWDMLKRLDWSQVSCPVVENKVGVGYYYNGNWICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3V4</accession>
    <name>A0ABR3V3V4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000407">
        <property type="protein sequence ID" value="KAL1836464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16556" checksum="A37322C9552F5935" modified="2025-10-08" version="1">MGRVRTKTVKKSAKVIIERYYPKLTLDFETNKRVCDEIAIIASKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEVSALDFSEAGTLDVDAETKDLLKHLGFDSIPVSVVPVTQNPVIERGGRRFGDRPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4T9</accession>
    <name>A0ABR3V4T9_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_4687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
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                <person name="Hansel C."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1836769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046226483" description="Ricin B lectin domain-containing protein" evidence="1">
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            <end position="169"/>
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    </feature>
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            <begin position="36"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00652"/>
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    </evidence>
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            <dbReference type="EMBL" id="KAL1836769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="169" mass="18544" checksum="96F0654EDF493601" modified="2025-10-08" version="1">MPGFSSVLLLALAATGLAQAPEGYRTVLITSNVDPKFVIVPKERQAGTTTIVKTRNDTPEQYWYLKDGLTKIQLANSTLCMDGGPRSNWRDMGNIYVNECADDTPSQEWFVMDDGRIALEPSERKQCVDLVFMRAVESNDVGLFTCAGLGNIGAADKGINWPLVDVEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_3789</name>
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    <organism evidence="3 4">
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        <name type="common">Soft-rot fungus</name>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000296">
        <property type="protein sequence ID" value="KAL1837418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34707">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34707:SF1">
        <property type="entry name" value="VIMENTIN-TYPE INTERMEDIATE FILAMENT-ASSOCIATED COILED-COIL PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1294"/>
            <end position="1313"/>
        </location>
    </feature>
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            <begin position="1322"/>
            <end position="1344"/>
        </location>
    </feature>
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        <location>
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            <end position="1414"/>
        </location>
    </feature>
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            <end position="23"/>
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        </location>
    </feature>
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            <end position="1387"/>
        </location>
    </feature>
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    </feature>
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            <end position="1373"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1538" mass="175438" checksum="3C1A273D81DC7B63" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Q4</accession>
    <name>A0ABR3V6Q4_HUMIN</name>
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        <recommendedName>
            <fullName evidence="6">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000293">
        <property type="protein sequence ID" value="KAL1837448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="305"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="644"/>
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        </location>
    </feature>
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        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="85411" checksum="69D63B8C43D04FEF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V728</accession>
    <name>A0ABR3V728_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC-2 type transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3626</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000280">
        <property type="protein sequence ID" value="KAL1837585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="6">
        <location>
            <begin position="84"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="183" mass="20540" checksum="AC2C1EB70620E8A9" modified="2025-10-08" version="1">MGFHHVEGQTTAEFLVTVTDPNTRTAKPGSVAEGIKSPEDLASAFKASQYYKSILTEIETYNQEQAGSATPLPSDKYRLSYPAQVRECLRREFHLVLGQRRVYYVKWLTTVILCLLCGSAYFDIDNTAQGAFTRGGILYFSLIINGWLQFPELFDAHTNRPVVERQGETAPCHPYESSDGGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V770</accession>
    <name>A0ABR3V770_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000296">
        <property type="protein sequence ID" value="KAL1837422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="137" mass="15187" checksum="11A5871673CBAF73" modified="2025-10-08" version="1">MRLLTSGQVSLAVSSMIVFICTLALFLSGYALQQRTLRDLREAIRLADGTRRPPLPLAPSQPYPKSLWEKLGVTDKGNGDDAETRYVQKRPKGGNDAGGSSRTERLQSIREEMRASTAASRREAGGYYRPRKVVGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7J6</accession>
    <name>A0ABR3V7J6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000265">
        <property type="protein sequence ID" value="KAL1837765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="474" mass="54162" checksum="77AB7049275EBB85" modified="2025-10-08" version="1">MDPQSTSPLVHLPLEILLRITHHISTVDLGNVRLTCRALERATFSFFSHEFFRKKQFMITTFSLQVLLDISKHPTLSPCLKHVILSTDRPKATEPWGRVITEEQSVQLELALADHMQLLTTGRLRDMLTDVFTNLKHLETVDIRNFNSPSRHRDRTQWRSYGARTLEAASHVRVYASPWITNDPYPSEVFTATTAALAAAQARPKSIEVLERNRGHDGPFSLQDAAFYIPPHIKSSMASLLGGLESLHLTMSFHPRKEPFMIQKFLALATNVTWLRLNFHCLHVDHPECVISWLGQDPGFSQTKSFETPPAKLPKLERLDLGDATLNYKSVLRLLTKFAPTLKSVSLRRICFQDDENMNRDEPVNPWNSFLKAIPRIPNLDLKVLDISYPRTSTYHWWIDVTFEQSGGRNPPTQWQCTTSTMTMEKAIEQALEAIRIKWPSWGRSATSESESEESDEMEEEEENEDDGGEEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7K6</accession>
    <name>A0ABR3V7K6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000295">
        <property type="protein sequence ID" value="KAL1837431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026093">
        <property type="entry name" value="MGARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22910">
        <property type="entry name" value="PROTEIN MGARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22910:SF6">
        <property type="entry name" value="PROTEIN MGARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="554" mass="60497" checksum="6D8B614785824C2B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7T5</accession>
    <name>A0ABR3V7T5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000256">
        <property type="protein sequence ID" value="KAL1837869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045359575" evidence="1">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="90" mass="9552" checksum="D104774ADB70D4F4" modified="2025-10-08" version="1">MLLSTFKTVFAILAAAGAVSALPRRGDPCSSPGSYDCIDDFYNVGICSTLGRWEVAASSTEARGAWPGYQPSHAGFHRYGPGRAGARRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V7Y3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000259">
        <property type="protein sequence ID" value="KAL1837832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
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            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
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            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
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        </location>
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            <end position="460"/>
        </location>
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            <end position="513"/>
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            <end position="613"/>
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        </location>
    </feature>
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        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
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        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
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        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120399" checksum="3079912ED6B31EEF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8D0</accession>
    <name>A0ABR3V8D0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000254">
        <property type="protein sequence ID" value="KAL1837895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="676"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8T6</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000229">
        <property type="protein sequence ID" value="KAL1838230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="470" mass="51989" checksum="07769A3955399B9B" modified="2025-10-08" version="1">MYLRGPFADDNIRALQEDGSNCSIFSFDITANRSALPLAKNALKKLRTLRHPGVIKVLDTVESDTYIYIATERVVPLRWHVKRKSLSPETAKWGLYNIARTVKFINNEASSVHGSLKVASVYTTESGEWKLGGFEVLSNVKEDDAVIYTYGSLVPDSGRYTPPELASGWDALKRSPHSAVDAYGFGALVFEVFNGSFNGGDQAGQTKNIPPSMHSSYKRLTNANPKARLSVANFLEQGRRHGSFFDSPLIKLTDGIENLGVKTEEEREEFLDDLEQLTDDFPEDFFKMKVLPELLKSVEFGGGGPKAFGVVMKIATKLSNDDFESKVTPVLIRLFGNPDRAIRVCLLDNLPLMIDRLPQKLVNDKIFPQIVTGFTDVAPVVREQTLKSVLTLVPKLSDRTINGELLRYLAKTANDEQPGIRTNTTICLGKIAKHLGNSTRAKVLIAAFTRSLRDPFRTAHCASCPPSAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Z1</accession>
    <name>A0ABR3V9Z1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000231">
        <property type="protein sequence ID" value="KAL1838201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="929"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="115050" checksum="3CAB95008CECAE16" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA16</accession>
    <name>A0ABR3VA16_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_2478</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000204">
        <property type="protein sequence ID" value="KAL1838610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1838610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Henrissat B."/>
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        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000175">
        <property type="protein sequence ID" value="KAL1839099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="435"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="506" mass="56164" checksum="78658EF268D96556" modified="2025-10-08" version="1">MGQPDKVSAPDVPTTESDSVTNEKTATKDPGVGDITVESAGWDVSSTKKLIRKIDVALIPFLSLLYLLSFLDRSNIGNARLDTLEKDLNLDPARLQYNDALAVFFPFYVFAEVPSNMAMKRFRPSIWIPSIMVAWSICTTLMGIVHNYAGLMACRSALGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMRGVGGLAGWQWIFILEGLLTFVVAIIAYFVMQDYPATAKFLTPEERTEVEGRLKRDRSSLADEFNIKFFWDAVKDWKIWVHMFITIGVYTGLYSYSLFLPTIVNGLGTAKTPEIAQLMTVPPYVVACIFCVGAGWYADKMGQRGIFMIGFMLIAIIGLIMLIATDNSAVRYLGCFFLATGIYPNVPQGVAWNGNNIGGSLKRGVGIAMHVGFGNLGGTISAYLFLSKDGPRYIPGFVALLALHVMALILSIIMTIYLRRENARRNRLYKPPSEYTEEERLAEREKGDLASFFRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBA3</accession>
    <name>A0ABR3VBA3_HUMIN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000178">
        <property type="protein sequence ID" value="KAL1839052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="286" mass="31495" checksum="878C9A1C42F618BC" modified="2025-10-08" version="1">MAPPAPPSPQSRVLRAAEAIRQRQQKPPQPKPSADPNTDPFAALLNEQTRPLLLPRVGDHARAVTLAPRQQQTPTATFTTIITTSTTIIPSIPTDTIPEHYGSLYSGPSPGAVAGITLGAVAGFVLLLWTVYWCVNLGNPDVTSTIGGGGSTVVTEGSGSVYVRRRPVPPPERERVRRVVREREEHRHSHVRRGSRGSGRPPVIVDEMTESSVMSPASESIVVEEEYERRRRGSRRYEHPPRPRPPPSSVMSDEDEVVVIEESSGGPSTPERRRRRSTRGSEPRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBX7</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000164">
        <property type="protein sequence ID" value="KAL1839315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="91" mass="10089" checksum="D179DE1A9596C84B" modified="2025-10-08" version="1">MEANLHHEDASAARSGLPSAAQSNWLTFFDLPSEIRNKIYDAVLFNPDGVWPGDWLEPVMVPEEKLPDIAPLARAEPNSGLVYKPTSQCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCA0</accession>
    <name>A0ABR3VCA0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000173">
        <property type="protein sequence ID" value="KAL1839132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="172" mass="19950" checksum="AD7C6146E841B3E6" modified="2025-10-08" version="1">MSQVTTSQIDSIRYQKGLDGEARAICTLEWIARLVTPIMQDHGWRLQLLEEMHPDEHTNWLGYNAGQKEIHLRLRQPGEPVVFCHTVHVISVMLHELAHMVHWEHTLDFYDFHEQLFCELEAAIKAKRVAFPEKDKLPAWWVGPAPTLPLPRGVDPRDNTSKFVAFARLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCH8</accession>
    <name>A0ABR3VCH8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhomboid family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000150">
        <property type="protein sequence ID" value="KAL1839565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24795" checksum="8D52A300D1CF9F2A" modified="2025-10-08" version="1">MSSSDPPSSSPSSTTTANKPEPDLPERNPILHNAALGLAVLAPIALVLPSRGKAKWTLQNALLGGTAFWAFNQLAHDYTGKSITARSSERWGALLGFSKKEGGKSGETKAEEAKKEKKAGIFHDLPTERAVRNKELIEAERRRRAEAEGREYVPHEEKKRGFWGRLWMGGEKEGWRERRLEEERKALESGKGYGGLIVDQVKEVFEGWGSGKKDGEGERRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCJ6</accession>
    <name>A0ABR3VCJ6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000153">
        <property type="protein sequence ID" value="KAL1839502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="360" mass="42172" checksum="497768C90A536547" modified="2025-10-08" version="1">MIKADDLVALSDAELDKYLKDNKVYDGSEIAFRLDVRAPDKLPQSFLEKLRERAQDIIAATYGSEPLTPTPVNYRSKVFAHLPWPTSLPVLPRDKEPRGPRYPRVKIYFGPRPRHQIRVPTPPELRERKCYEELLAKGGRSNLDLESIPQIIHEPGSFPQVRSVWMYNPEHNDKDVNIMERQLNHWTDFRAWQRWNRQKDAPLDIQEPTSKAHHIFRRWVQDFREDSSYLTAAMKILTAFGFTKLPVEIDEESSLRQDKLTEWIEYLVFECATFHYWKHILDAHQAKFDRSWDELVEANVLLPTGHKQDVVNLSDWAEEPGVANVQRKPLEESESKARFVLPRLARDHEPGTGDYQLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCX7</accession>
    <name>A0ABR3VCX7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Inositol oxygenase</fullName>
            <ecNumber evidence="4 12">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_1417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 12"/>
    <dbReference type="EMBL" id="JAZGSY010000151">
        <property type="protein sequence ID" value="KAL1839554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="313" mass="36278" checksum="A2898E143D7D1285" modified="2025-10-08" version="1">MATAVDTRPPRDGPGLEAISDAVDAINVFKGRATAEESAFDNPSVFDADKDKTTFRRYNEACDRVKAFYAEQHAKQTVAHNLAARERFYSPDRHRPEMTVWEAIEKLNELVDDSDPDTELSQIQHLLQCAEAMRRDGKPRWMQLTGLIHDLGKLMLFVDGCCEGQWDVVGDTFPVGCRFDERCIYPETFAANPDSYHEVYSTRHGIYEPGCGMDKLIMSWGHDEYLYLVLKDQCTLPREALAMVRFHSFYPWHREGAYMEFMAEGDEELLHAVRAFNPYDLYSKSDDPPRVEELKKYYLELIDEYFPQKIVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD38</accession>
    <name>A0ABR3VD38_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000142">
        <property type="protein sequence ID" value="KAL1839735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017210">
        <property type="entry name" value="APP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037464">
        <property type="entry name" value="UCP037464_APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="360"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="819" mass="88170" checksum="313C973A3887AB2C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDC8</accession>
    <name>A0ABR3VDC8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000141">
        <property type="protein sequence ID" value="KAL1839766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1396"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1408" mass="158883" checksum="1488196721CBBA58" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDH7</accession>
    <name>A0ABR3VDH7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000142">
        <property type="protein sequence ID" value="KAL1839743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047290412" description="CBM1 domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="794"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="830" mass="88981" checksum="E421DBE98981C53E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDK5</accession>
    <name>A0ABR3VDK5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF32">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="63264" checksum="F89EB60CBC966B76" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDL8</accession>
    <name>A0ABR3VDL8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Methenyltetrahydrofolate cyclohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_975</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000133">
        <property type="protein sequence ID" value="KAL1839970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="13">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="14">
        <location>
            <begin position="143"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1839970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="940" mass="100057" checksum="AE261CA473A6FF30" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDW0</accession>
    <name>A0ABR3VDW0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000157">
        <property type="protein sequence ID" value="KAL1839433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="362"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="691"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118919" checksum="C5B4A0916BB3D039" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDX4</accession>
    <name>A0ABR3VDX4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="223" mass="25317" checksum="B4FA8FC264580467" modified="2025-10-08" version="1">MSGVWGWFGGGAQKRKDTPKNVILDLRTQLEMLQKREAHLTRQIEQQEQIAKKNVTTNKTAAKAALRRKKLHEHDLEQTLNHITTIEQQINAIESANINQETFMAMQRAGAAMKQIHGKLTPAKVDETMDQLQEYNRLNEEISEAMSSINVGPQMDDMELEEELAELQQKELEDKMLETGTVPVDNIQRLPTVANGEVKGKAQAVAEDDEEEELRRLQAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEG3</accession>
    <name>A0ABR3VEG3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000135">
        <property type="protein sequence ID" value="KAL1839912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21189">
        <property type="entry name" value="PHA02142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA ligase" evidence="2">
        <location>
            <begin position="337"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1048" mass="114950" checksum="48A3FC45DF814544" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEH5</accession>
    <name>A0ABR3VEH5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
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            <end position="448"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Otillar R."/>
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                <person name="Nguyen T.T.M."/>
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            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Haridas S."/>
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                <person name="Grimwood J."/>
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                <person name="Clum A."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000142">
        <property type="protein sequence ID" value="KAL1839748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="378"/>
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    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="411" mass="44568" checksum="5A09EEF18584D221" modified="2025-10-08" version="1">MSIDKKEPPKEDHRSPESMASSPEGEAHAPPQQQQQQQQPSQQPAEGQQPKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIKQLEEAIRTHEQNLANLQAAHRHAADECLMLRYKNSLLERILLEKGIDVQAELRAKTGSPHLGPTPMPPQNLVQPPPIQRAILNRHHARRSASGIAPKVEPGIPASPLPPPMQSHASAMSPKTRGTPSSHSASPTTTTPFSSQHAASPVGSDHLNGSMRQAMSPVAAMKPPQTMAPPMHGLPGPGGVNRPMQLPGLQQGVSWDFVVRRFNAWSTEQEYDAAADMMDDPDNTPDTPSGPGPFPGAEYTTTSEPQAMQLSSPVTTGPPSNPSMAQSPMTDNAAASTPHSGAYPSMSQLMDPGYDFDPFGLSASMAFPTQFSFDTSSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEZ3</accession>
    <name>A0ABR3VEZ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000144">
        <property type="protein sequence ID" value="KAL1839701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="33"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="187" mass="21168" checksum="35784B33E8B2C5BD" modified="2025-10-08" version="1">MLKIWSMKKEQQKAENAAEGTTAAAPKKKKVTAAQLRVQKDLSELSLGNTMSTEFPDPDDILSFILYIEPDEGMYKGGRFSFTFNIPTSFPHEPPKVQCREKIYHPNIDLEGKVCLNILREDWKPVLNLNAVIVGLQFLFLEPNASDPLNKEAAEDLRNTREMFKRNVRTAMAGGTVRGETYHKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF21</accession>
    <name>A0ABR3VF21_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000119">
        <property type="protein sequence ID" value="KAL1840307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="63"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="372" mass="40385" checksum="3A93F9662F9ABF64" modified="2025-10-08" version="1">MSPIAAATMPVDEALSLAATDGMPGTDAGAVPFDPKLASEDNGKITLIVAWFMVALSGAFTGLRLYAKLSRGRPLWWDDHVLVASFILMVADSIILCHMVTLGYGKHFFMVPFENVPDLALFGNITLTFVVTALAWTKTSFGITLLRFTRGWIKKLVWFIIISMNLLFFWAALIHWIYCKPLPKAWNPFLPGTCWSYELVVDFDIVAGAYSAFMDVSLSLIAWYMVRSLSMNIREKIGVIISMSLGGFAAIFAIVKCTYLPTMLDNDVAFTGTYLAMWGLAEVAATIIAASVPVLRALVAEKTSANRSRGPTYANGTGVNGRYSTLGKTNHSVSVHHTVSVHHTDAGDSDVALQTVTIAGKASTRGSTPEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF79</accession>
    <name>A0ABR3VF79_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF2">
        <property type="entry name" value="PROTEIN CON-6, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03615)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15774" checksum="342D6610E3CB57FC" modified="2025-10-08" version="1">MSNAHSNRERGLRAALNNPRVSEEAKQHDRELLASEFGEHIEEEPQPATQSKRRASSSKKGAGAKVEPPKAEGVEAQPATGRRTRRASSGDAGMHQQQQAKGEEKDKHNVIRGLKAALKNPNVSERAKEADRKKLAELGEPVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFB1</accession>
    <name>A0ABR3VFB1_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000108">
        <property type="protein sequence ID" value="KAL1840555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="265" mass="28187" checksum="3F30D633E82C0AD8" modified="2025-10-08" version="1">MATTPLSPPLLYPPPESLTYDPDPDPDSDPEPQRGRNRHRLADEYDNVNKDHILLFLSRAASNQHHPGSTESSTFRGRPRHRSSSPFFFSSFLATPAFPTPKCGTPAPGATGQAVQTTVPTAGAVPVPVPVPAIFLLRAAAVCAADVGGAEKTREPLPGKGMGRRRRRRSASPSRSRSPAARRVEEAAAGGATTADSGSDGSEAEGVGREWGGARSVGRRVAGPGYDDDDDDDDDDEESGVDTNGRRGSRRRQRTRSRGGGHRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
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        <name evidence="8" type="ORF">VTJ49DRAFT_772</name>
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000126">
        <property type="protein sequence ID" value="KAL1840116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
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            <begin position="1"/>
            <end position="262"/>
        </location>
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        </location>
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            <begin position="391"/>
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        </location>
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        </location>
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            <begin position="468"/>
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        </location>
    </feature>
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        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="552" mass="61937" checksum="491F1A219F9703BC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFL7</accession>
    <name>A0ABR3VFL7_HUMIN</name>
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        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">VTJ49DRAFT_999</name>
    </gene>
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        <name type="common">Soft-rot fungus</name>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000135">
        <property type="protein sequence ID" value="KAL1839911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dimeric alpha+beta barrel"/>
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    </dbReference>
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        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="123" mass="14354" checksum="859F19987070895C" modified="2025-10-08" version="1">MASTGTTLFLTLHIAPEKLDEFFELFRPLVEKVVAEPECRSFHVYKDPENPGTITIVEHWNATVEWLMNVQIKKEYYKENFEKTEPMFVKPREVRILQPLGPPYDVTKDGNSYGYKQGVVTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFQ8</accession>
    <name>A0ABR3VFQ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000126">
        <property type="protein sequence ID" value="KAL1840123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045641120" description="Invertebrate defensins family profile domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12323" checksum="BA57F25C6A34B94E" modified="2025-10-08" version="1">MQAKFLLALFGSFAIASAAATPNPQAEVTDIVVIETSGPVGLPEVEARDVEARAADINWQATGGCKMDWADRCNAMCRGEASQRKYSCKQIKSKIWRQSCVFGWSVCDCTCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG91</accession>
    <name>A0ABR3VG91_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="9">
        <location>
            <begin position="71"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="422" mass="44920" checksum="D53573A3049D8255" modified="2025-10-08" version="1">MPSKTASKSAGDSGNFVDDYLADWDQDDLFGSPSPEPGKKDKQKEPEKKKDVLGVDDELNLKRKPRVPRVKLDEARLLSEKGIPKLRKMGPRIKFKGKGHEFDDAARLLSFYQAWLDDLYPKATFLDALAMVEKTGHKTTMRNARLKWIDEGKPKAADADNDIFDEDNRINTRPAGAQQAERVAPVFEKAAAAGQQRAKTPAREDLFGDDDIYNATPLRPTAGTSGAPRSADNDVPDDEDLDALMAEAEAQTSSFAASKPSQTAPSRSIFGGGPGGPPDDDDDLEALIREAEGDAAPRQPTRPAASSSIFGDGKPREPATAAAQDEGDDLDALMAEAEAEGQSSAKPVTDKKIVSSGGQKEGQGAVIDDGDDLDALMAEAEAAAGPPSNSANSGPSGGTGGGNQTYDYEDDEEVLAEMEGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGG9</accession>
    <name>A0ABR3VGG9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_7631</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1840889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="359" mass="39833" checksum="7ED8FA452B5C6214" modified="2025-10-08" version="1">MFRSAPPGPYDEAVNKATDENLTSEDWGAIMEICDRVSGDPNGPKDSVASLIKRLAHRNANVQLYTLEVANALSQNCGKNMHRELSSRAFTDALLKLANDRNTHAQVKTKIIERMKEWSDMFKSDPDLGIMYDAYFRLKQANPTLEPPSAPQKNQLTDLDRQKEEEELQLALALSLQEEERKKKATQPAAAPSGSGSGAAASTSAAPAQQQSTQQSAPHPVPPGTTAATVSRVRALYDFVPSEPGELEFKKGDVIAVLESVYKDWWRGSLRGKTGIFPLNYVEKLTDPTPEELQREAQMEAEVFAEIKNVEKLLTLLSASNTGPREEDNEEISKLYHQTLAIRPKLIKLIEKYSQKKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGM0</accession>
    <name>A0ABR3VGM0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000107">
        <property type="protein sequence ID" value="KAL1840581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="491" mass="53039" checksum="B545B0D89BAEC89C" modified="2025-10-08" version="1">MRGTLIFAGSSCPELTDKICQNLGMARADAELTQFSNGETSVRILTSVREKDVFVVQSGSPKINDTIMELLIMISACKGGSANKITAVLPYFPYSRQSKKKSHRGAITARMLANLLDVAGVKHVVTVDLHASQMQGFFRCPVDNLHAEPLIARWIRRNVPGWQEAVVVSKNAGGTKRVTSLADALKLNFGMVTTDKKRGNNMSASMTASMFLDGPERQPTPDATANQVRTNNSSETENGIPATDGSDARDDAGAPGSPRVNGNGTHSHEPPLRRSETLLSQSSVVDEVDEEYEADGLEYNDQRAHEVTHGRLVQGHVVPDDFPSPAVSAVEASVHEEDPMMLSHASSFFSPQPHALGGAGDAGASSDEEDDILKDPKVERTITLVGDVKGRTVLIVDDMIDKPGSWIAAAETVVKRGRAKKVYCIATHGVFGGDCLEQMEACDCIDAIVVTNSYPIPEHKLRNATKLVVLDLSFLLAEAIRRNHYGESIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGU9</accession>
    <name>A0ABR3VGU9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000094">
        <property type="protein sequence ID" value="KAL1840922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="6">
        <location>
            <begin position="530"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="956"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1085"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1110" mass="118505" checksum="6719A6E2D8426570" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH22</accession>
    <name>A0ABR3VH22_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="228" mass="25689" checksum="959E0577778DD6D4" modified="2025-10-08" version="1">MTVVQEHPVAVQEIPLAAFRAMGTTKGPAILPDESRLQVDQALREDRYLVVSPYDEQDHLLDLETLDAENQFLALALTKLKCLRDDYATAPYLETFNWDKVIDTLRTLAHETGHRWKETSFFVVAFRSRIPPTTVYAELGALDKAAHAEATASGGFLKYWFGTPDSEGRNLATCIWRSFEDARKGGTGPAHRKAAGAARSLYSFWKIDRLKLTIRDDISGWDITNWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH58</accession>
    <name>A0ABR3VH58_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000113">
        <property type="protein sequence ID" value="KAL1840436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="645" mass="71352" checksum="FA7A15477DA6E977" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHD2</accession>
    <name>A0ABR3VHD2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cleft lip and palate transmembrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="74025" checksum="BAFF0C6581315E5E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHM9</accession>
    <name>A0ABR3VHM9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000093">
        <property type="protein sequence ID" value="KAL1840941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="114"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="213" mass="22878" checksum="16B954E63D006C2D" modified="2025-10-08" version="1">MSNEPSTTPNPAPPVPPNLPQPSTLPQPKPLSNLPQLTRYITTHRASDGLATLHSQTPFLWAGFDEDNLGFAVPFTTSTFPADLNDGTDLATHDALVTSGRLGLVNPGGTVCRVVDFAPGYASAMHRTKSLDYGVVLEGELEMVLDGGDRVVLKRGDVAVQRGTNHQWVNKSATEWARMLFVLQDIKPVVVNGKELGEDLGPEGGLPETEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI60</accession>
    <name>A0ABR3VI60_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045163572" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="74" mass="8001" checksum="E346FA062407E648" modified="2025-10-08" version="1">MLLTSVLALSLSFAAPALGAATKWYSDPDCENFIDKKVYNGFATGDAIIPPEGVRAIKVDSLTSVWFGYDVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIB5</accession>
    <name>A0ABR3VIB5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CCCH zinc finger and SMR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000080">
        <property type="protein sequence ID" value="KAL1841307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="8">
        <location>
            <begin position="597"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="80132" checksum="E244D05593EEEE54" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIC2</accession>
    <name>A0ABR3VIC2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-hexosaminidase</fullName>
            <ecNumber evidence="6">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046814990" description="Beta-hexosaminidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="193"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="585" mass="65459" checksum="E6194EE1C43AA63A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIJ4</accession>
    <name>A0ABR3VIJ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">7alpha-cephem-methoxylase P8 chain related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32541" checksum="B02AAADD0EC8D660" modified="2025-10-08" version="1">MAITHLSPPAGHVVATLNFYSPPPDGSQPYNIAGDVPPGVTPRNYDTDPQPVLIHDARGKESTFTLDHDAFQVLQHQPPLSISDPHPEPFTSDASIRTNYFPEVERLLLKTVPGATHVIIFDHTLRRTSPTAARQPVARVHIDQTALSAAQRVRRHASSPEEADELLRGRYRIINVWRPLNQRPVESFPLAFASSASLRDEDVIPVEHRYLSTGYVGQTAGIRYHEGQKWYYLSGMTGEERILLECFDSEARKEGSKVKGGRVAHTAFEDPRTREGAEGRESIEVRALVFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIS2</accession>
    <name>A0ABR3VIS2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000080">
        <property type="protein sequence ID" value="KAL1841285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="132"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="226"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="335" mass="36260" checksum="7E3E81034F86AF4C" modified="2025-10-08" version="1">MSNQKDHLRDEGSRLQTTAAGATAGLIARFVIAPLDVVKIRLQLQTHSLSDPLSTRNLAGGPIYKGTLPTMRHILRHEGLTALWKGNVPAELLYVCYGAVQFTTYRSTSLLLHTLFGAGPESKDQSKHPLLRPAAESFIAGAAGGAAATAATYPLDLLRTRFAAQGNDRVYTSLLLAIRQIYHDEGPKGFFRGLGPGLAQIIPYMGFFFAAYETLRPVLSDCWALPFSSGAAVAGTIASVAAKTGTFPLDLVRKRIQVQGPTRGRYVHKNIPEYAGGAVRALRTILRNEGVRGMYRGLTVSLIKAAPSSAVTMWTYERALKFYGTLGLGEKEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIY6</accession>
    <name>A0ABR3VIY6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000064">
        <property type="protein sequence ID" value="KAL1841759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="597"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1110" mass="124150" checksum="3F85DA707C9F4EEC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ03</accession>
    <name>A0ABR3VJ03_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="801"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1173" mass="130844" checksum="FBB9FE7AF4E4D525" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ22</accession>
    <name>A0ABR3VJ22_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000077">
        <property type="protein sequence ID" value="KAL1841375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="76"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="429" mass="46379" checksum="EB888A1D35FCA170" modified="2025-10-08" version="1">MSSLYDQPAMASLSPNPPAQPAQPGFSTGLSAHSKSPLATLNLDFLRAVTEKRTTRDGQPQKRRGPKPDSKPALTRRQELNRQAQRTHRERKELYIKALEDEVLRLKEIFSNICHERERLVEENQQLRALLAQNGIPVGGSSVLDDSISNPSATSATGGYSPSSMAASSSSYPGGPASSNTTAITPPPLSASSHGQGRGGGISPHSATYPPLPQGQPGFYQQGNVNGGSAPQNQNPALDYEQAGIDFVLTLEKPCMNHLPWMLERGAATGIREPCGHALMASCPPEPFSDLSPDIPFGQVQTAATTAATHTGHAHSHTHDNGQQQQQQGQQGQEPGNATWTLSKGDLATLLDLSRRLDLDGEITPVMAWGMVLAHPRLGELREEDFVRLAEELKGKVRCYGFGAVMEEFEVRDALENIFSMKQEFGMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ56</accession>
    <name>A0ABR3VJ56_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46273" checksum="58F8919B03A21FF3" modified="2025-10-08" version="1">MSPSTKIFSLEGRGLKLDTAEDLEPHIADLRAMDDIEEVHMLGNTLGVGACKLLGEVLATKKTLRVANLADIFTGRLLSEIPEALSSLLTSILNLPNLTTINLSDNAFGLNTQAPLVAFLSAHVPLQHLYLNNNGLGPHAGILIADALSELHAKKEEARKAGQAVPDLETVICGRNRLENGSMTAWAKAFRLHNKVREVKMVQNGIRQEGISHLLSEGLRHASRLEVLDLQDNTFTLLGAKALAEVTPGWAELVELGVGDSLLGAKGGLVLAKALAKGENKKLKILRLQYNEITIKGIKALSDAIEEALPVLRKLELNGNKFQEEDEVIIKLQDLFDKRKEEQAGDVIIEDEWGLDSLSDLEEESEEEEEEEEEEEEEEDVKEKADKFIKEEEEAQKEPVAQRKDKDVDELAKELAKATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ69</accession>
    <name>A0ABR3VJ69_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000059">
        <property type="protein sequence ID" value="KAL1841935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="683"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="747" mass="81044" checksum="5463F3EB8C660C5C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJN7</accession>
    <name>A0ABR3VJN7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="452" mass="47942" checksum="93327F910E95152B" modified="2025-10-08" version="1">MFFRCSSAPPGAGGSGTQYPPPPTSSPPAQQYSSYPPPPAANQGWSYPPPSQAVTATPTPPTASTASYPPPPQQQPQYPPPPQPQKSPPPQQQQYPPPPQQQSQQFPPPPPQQPQQQQYPPPPPQQQQQPQYAPPPTSSPPPTQHGALPQHLRSPSTASQGSGHSAPQFAPPPAYPQDGANTGYPPEKQQTDEKDQQAQTQTQAAPVIDPTGAPAAGVFTGAVSTYVDDVGTFNGGSYRISHRDCNSVLTIQLAIGCPVEARPGAMIAMSPSIVLKGSYKFSMKKLVAGGEMGTSTYTGPGELLLAPPMLGDITSLRLTGRETWSVSHDGFLACTQNVVKDYKRQGLGKAIFSGEGLWVHKISGTGLLWLTSFGAIIRKDLLDGEKYIVDNGHLVAWNTKYVMERVSSGGLISGLAAGEGLVCKFTGPGTVFIQTRNARSFTAYMTGQQTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJS4</accession>
    <name>A0ABR3VJS4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endocytosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_6230</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF74">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="19">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="19">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="285"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1841987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="402" mass="45360" checksum="F8058CD20DD304BF" modified="2025-10-08" version="1">MAPRIEAQEIETYWNIFSARTNGGKYLTGEQAAPVLKNSGLRDDQLERVWDLADVDNDGNLDFEEFCVAMRLIFDLLNGEYSDVPSALPDWLVPESKAHLVQASRALTGKAVQFERVEVDDDDDGPGLKDGFDWYMSPADKAKYEQIYQEARDMRGEVSFSALQDLYDSLDVPDTDVRSAWNLINPSAAPSINKDACLAFLHILNNRHEGYRIPRTVPASLRASFERNQIDYRVDNAAAAKSRWATRPDDETSTGRKAKFGDQYLTRLGRSGFKSSGTDFSNSAASDAEWEEVRLKKQLAELDEKIAKVEAAAERRRGGGKRESKPALVRRELEQLLDYKRKQLRDLEEGAGRAKSAGSLRGVADDLQTVREQVEGLEAHLRSRQEVLEQLRREIEDEKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJT1</accession>
    <name>A0ABR3VJT1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="760"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="1564"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="734"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2401" mass="258818" checksum="B5B0E2CF0186B6E3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK57</accession>
    <name>A0ABR3VK57_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAL1842122.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        </location>
    </feature>
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            <dbReference type="Pfam" id="PF07985"/>
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            <dbReference type="EMBL" id="KAL1842122.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">Aminotransferase class I/classII large domain-containing protein</fullName>
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    </protein>
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        <name evidence="6" type="ORF">VTJ49DRAFT_5283</name>
    </gene>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
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            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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    </dbReference>
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        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
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        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="42"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="432" mass="48705" checksum="8E4C53939D6B3B85" modified="2025-10-08" version="1">MLHVSRPFMTEKLKPAARVRGQRQDVWSIINEAAAASPIQPIVNMGQGFFGYNPPDFVLKAAKEALDRVDCNQYAPTKGRPRLKKALSDAYSPFWGRTLNPDTEITITTGANEGMLSAFMAFIEPGDEVIVFEPFFDQYISNIEMPGGKLVYVPMHPPKAGAVKTLSAAEWTIDFDELERAITPRTKMMVINTPHNPVGKVFSRAELERIASLCLKHQILILSDEVYDRLYYVPFTRIATLSPEVENITLTVGSAGKNFYATGWRVGWLIGPPHLIQYVSAAHTRICYSSVSPLQEACAIGFEQADAQGFWEESIKSMRHKMDLFNAVWHELGIPYSEPEGGYFVMVNLSKVQIPEGYEFPPHVASRPRDFRLAWFLIHELGVAAIPPSEFYTDANAHIVEDYLRFAVCKPDEVLEEAKERLRGLRKYLKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKY7</accession>
    <name>A0ABR3VKY7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="58"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="414" mass="44880" checksum="4FAEB0185D3871C5" modified="2025-10-08" version="1">MVRSIAAVAAAAAVKVAAQSSTTSSEFPFPTDDLPTYNGTGPTMLRFGCHQLVIDRIDPLVAPGQVPSHHQHQIVGGDAFNATMPHSDISALSTCTTCSYSDDFSNYWTANLYFRARNGTYKRVPQIPNHTDIFTNDTFITQTNGGMTVYYVSPGQNQVTAFPPGFRMFVGDATLRSPPDSPWDLSTQTCFRCFTGPDFGGNMLRPCLDPAVDTMHLPNQPCWGIRANVLFPTCWDGVNLDSPDHKSHVAYPVEGPHIFDGIGTADECPPSHPVKIPQVMLEVIWDTTPFNDPDEWPEDGSQPFVLSTGDPTGYSQHGDYVFGWKDDALQIAMEAGCFMANCPGLAVQTVEQAAQCAVAEVAGDVYDGWLTELPGDPVQPPVTTTSEAPEPTGKGKGDEGKGKKGKRKAKRWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLL0</accession>
    <name>A0ABR3VLL0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="197" mass="21561" checksum="FF2B9DD563DE11AD" modified="2025-10-08" version="1">MGAGPLSILPSKHPRLDFGAKPCCADNGYRGVWMYAGRRRMLDDVGKVAFLVGQLRRPWLLGPPPSLARQSLLVCVGIVTFEAGRLRASPRESKGSILGKGLAVVHAPKGGIRPGTSLHEGDLILESERGGRAWKAIKKPGMSSRRRLSAPRCGPRAQMSPHTLGTGRVTTVQHQSFVFVSLCLYSRIREQWWRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLN8</accession>
    <name>A0ABR3VLN8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="25359" checksum="9ED59427CF58B761" modified="2025-10-08" version="1">MAQPGAEPEPFRDGDFDIFDWHLHFQSCVRYFLEHAQFSGPIQALAAYLNIQLPFQRTYTAAGPVLAGMPILPLAPAPPPAGPAAASVAAAAAAAAAAGYVSLQPYIRRLVVTGYDTPAVLYGFFGDDWRRGVGPLHEQERRNYMFAAKSGSWLDVWRAYGDGGGAGVAGHGGGGGGGGGGGGGGVPGGLGVGYRPDETVPFLRPLRDPTEEEIRVAEARWSEWLAMQDWMIGPRAEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLX2</accession>
    <name>A0ABR3VLX2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="449"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="767"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1103"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1276"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1410" mass="154642" checksum="69E6C155CA094EEE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM99</accession>
    <name>A0ABR3VM99_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="Natvig D.O."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1843015.1"/>
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    </dbReference>
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            <end position="162"/>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Nguyen T.T.M."/>
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            <strain evidence="4 5">CBS 620.91</strain>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
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    </evidence>
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</entry>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05824">
        <property type="entry name" value="LbH_M1P_guanylylT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="13">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="14">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1842921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="364" mass="39844" checksum="6B6C5AF2D4C2F0E1" modified="2025-10-08" version="1">MKALILVGGFGTRLRPLTLTLPKPLVEFCNKRMILHQIEALAAAGVTDIVLAVNYRPDIMEKYLVEYEKEFGINITISIESEPLGTAGPLKLAEGVLRKDDSPFFVLNSDITCEYPFKELAAFHKAHGDEGTIVVTKVEEPSKYGVVVHKPGHPSKIDRFVEKPVEFVGNRINAGIYILNTSVLDRIELRPTSIEQETFPAMVKDGQLHSFDLDGYWMDVGQPKDFLTGTCLHLSSLAKKGSKLLTPNTEPYVHGGNVLIDPSAKIGKNCRIGPNVVIGPDVVVGDGVRLQRCVLLAGSKVKDHAWVKSTIVGWNSTVGRWARLENVTVLGDDVTIGDEVYVNGGCVLPHKTIKSNVDVPAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN76</accession>
    <name>A0ABR3VN76_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="266" mass="30224" checksum="516E3AD070077F96" modified="2025-10-08" version="1">MAIRPVDGWLPLTDECLHYTEESEVPPDLKKYWHQRYSLFSWYDYDILLTHDAWFGVTPEAVANRIAEDMPSHNLSNPPKDIIVDLFAGVGGNTIAFALSGKWDRVIAIERDPATLACAQHNAAIYEIPEGVITWVLADSFDYLARVKRQQQQQVRKHELVDPALDLDFSRTVLFASPPWGGVNYRDQEIFDLNTMEPYNLETLHEACRPMEHALYLPRTSDMRQIAKLAPKGGKKIEVVQYCMEGASKAMVVYLPAEEDASNQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNB4</accession>
    <name>A0ABR3VNB4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="802" mass="85421" checksum="79F14E3FA9007C33" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNS4</accession>
    <name>A0ABR3VNS4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF94">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="791"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="862"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="925"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1106" mass="119633" checksum="D94C1AF1EC1E4FEF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNU7</accession>
    <name>A0ABR3VNU7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein mis14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26703" checksum="12E2111600ECF9BC" modified="2025-10-08" version="1">MDAQTQRRIELQVPEDLTYLIDNVRKAAADSINAAFPPVDDQLDGQEDELRNRIEELVNDYILQTFTLAAPNLTINGLPVTNITSFLPPNFHTSSGTTTTAPSSTNPQQPEVQYEYEPFDPRKRDRIEQLISEEEDLLRSIAALKRRAPGATSSRWAETSSASLAADDAGLEALEQKLEEEGAAAGKRALEGMGALERQGEIEKRFVEAVEGLGRLKTEMPAARAKMERARGAAGYVMGEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP42</accession>
    <name>A0ABR3VP42_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="419" mass="43917" checksum="48F6A25B25C2BF20" modified="2025-10-08" version="1">MSSDISQQPSQGAHPTLIDLPAPPSNPDTPSEVPGTPTSTTTSLSALSTIAIKDGHRGAIHHRSHLHSPSPNSLEAERADRISRLTGLSSVSALHNLATGQPRHNVGSQQTTPTSSGFPAIPTGAVLTPAYFDAAGQPVAVTKVSTVGSASATESVGGQTSTSTEVGDHYTTADDRDEDILTEMDSVSMSGYMGPDAMDEDLDNLTSRSVGAYEDRMSDDGNASLVGFGEGAGSTLSGPIYQRRPPAVQGGASGQGPTFTSPPERSSSWYSDGVAPVSSPNPHPSGPALRRDFTAPVALSVERDLGSDTGINQSAAREMLEARMLDGVAVDRTAPGAASMVEARPRHQQPSRVRACTITTTTQAYLDVASSIQPLDIARDSTTIRPMCHVPSSIPRCHPQRLRLHRQRATQQKTRFASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPB1</accession>
    <name>A0ABR3VPB1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="404"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="541" mass="60467" checksum="8CAD057F1AFE9899" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPH6</accession>
    <name>A0ABR3VPH6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="468" mass="50211" checksum="3566D041D7BE0CC7" modified="2025-10-08" version="1">MADQAANELLSTQKASDLGLQVVLHPLPILEISDFIVRGYQRGFQGAVVGALMGQQNGRDVTIEHSFSCKAAKNNDGFYELDEQWFRQRLEQMRLVHKSPQLDLVGWYSLVPKTGPTAQHLPIHRQISTYNEAAVLLGFHVEEVLDQKSTAVPITIYESNLEPADGHTATSATEDHDMKDAETAANLVLRFRKLQYTTDAGEAEMIAVQHIRGSGGGAAAVAADVAEKNIVEQFDKKIAVDDGKGKRRAVAYQDPSKPKQEETAASTSATPANEDANLSPAESEYMAALQAKYNAVRALKSRLDLFIAYLQRLPPDFVAGTQTTSDAAAFARASNGQFTIPSNNILRRIQALVTNAGLAAAPGHDDPIDTEISSLSREIQRETNDVRLISLTADLLSSVVEMRDACKKALVLDSARHQRMGPRGPAATVAAMAGLAGVPYDSALLAAGDLEGVNVSSLDGAGPSSLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPP2</accession>
    <name>A0ABR3VPP2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Actin depolymerizing proteins"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="8">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="8">
        <location>
            <begin position="175"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="333" mass="36782" checksum="30B647F39F940287" modified="2025-10-08" version="1">MQSGISASQELVSQFNDLLASDRHFGLLVTISSEQLKPLQLLTPAASSFASSVESLLAPHIKPNEALYIILRRHPSAPALVAVTYVPDTAPVRQKMLFASTRLTLVRELGSEHFRDTFFATTADELTPAGFERHDAHLALEAPLTEEEQSLGAVRRAEQEAGMGTAVREIHMSKNMPTQMDDDALQALKDLAAGGSRSLVMLKINPDSESVELAPDDSNPSSIPELVRAISPSEPRFTFYRFTHTHNGSESSPLLFIYSCPSSFSTKAIKYRMMYPLMKRAVLSIAEKDAGLTLDKKFEVEDVSEITEQSIMDELHPKVEVKKGFSRPKRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQL9</accession>
    <name>A0ABR3VQL9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045439059" evidence="1">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="150" mass="16084" checksum="036771EB276329BA" modified="2025-10-08" version="1">MKATIYLLNFLALGAFQAQASAIPVVEKDQSSANPLAPRQSIYKPCNNGEIGLGVSQHCGITTGCGGEFATIFDNTCNNQWSVGNDDPDVCKGGWTRGWSVSCSGGNPREVRDGSGKRYGNCYVPKEGYCGLTIGWSSLYNVVQFCCRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQQ7</accession>
    <name>A0ABR3VQQ7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="926"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="837"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134566" checksum="2DE97A8EE5E8BDD1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR55</accession>
    <name>A0ABR3VR55_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4936</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="132"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="284"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1844084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="44937" checksum="67A7AFECE0281E21" modified="2025-10-08" version="1">MSADFWAGYISGAASIILGNPLDVLKVRLQAGFASSSSSPKPPAPHSPSYLAAHHPLTPTTTPTTSFATSYIRPFLLGTAAPVLGYGALNALLFVSYNRTEAFLNRYLASPNNNSSSVLAQDNDDGFQTRGTNLLTTWLAGAAGGLATWVVSAPTELVKCRAQLEIPAQSLPTSTATAATAAAASAAASVLPHSTPAPQQQQQKSPPSATSLSIARSILRTHGLRGLYFGGGVTAVRDSVGYGFYFWGYELCSRWMTALTSPGPGADGPNGDSGSASGGSIWTSDAARVLLCGGLAGIITWASIFPLDVVKTRMQAQPDVFLPPRGAGESAPLLGGDDGRRSGVEGGQQQQQQQQQRRQPRLSAWAVAKDTYREGGTRAFFRGLGVCSARAFVVNAVQWAVYEWIMAELGQGRRKQQQVGGEEAVVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR59</accession>
    <name>A0ABR3VR59_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="499"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="645" mass="70140" checksum="2D280B4AA1D7FD59" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR68</accession>
    <name>A0ABR3VR68_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="188" mass="20309" checksum="895D9C970C71158F" modified="2025-10-08" version="1">MSSLREPTFFGFVATTLDAAIVVDAAIQGQLPLWNSAPTENELDLLISSGSIFVHGGGTSDIIRWRDRRLWSDRRAISHGFDIYRELAREPHEALTAAELQAEDAFWNQAPRGKAGRKVTIVNDSGLAPAENPAGWKAAGPVPQPTQNNLAALQQLGVLPSPEGSAAEQGSCSEEETEEEEAEMEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR93</accession>
    <name>A0ABR3VR93_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">VTJ49DRAFT_6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="415"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1844327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="514" mass="55539" checksum="A771266913067E25" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRA9</accession>
    <name>A0ABR3VRA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_4988</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="132"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1844136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="469" mass="51443" checksum="D4B18A0BAB5E30A1" modified="2025-10-08" version="1">MEVARVAGAEVGRVSRRILQKIWDPEPTNDRASNEPVWCLGRSYTLAKTSEQQPPTPGGVGVPPTAGKAEATAGPASTTAEPSLPPTITTTTYSSLSGEQAPETPPDSTASSSVDSSLAYDEDIEDRGWPPAFLDDFESRIWMTYRMGFELIPKSPDPRAAAALSFTMRLKTSFGDFMGFTSDTGWGCMIRSGQSLLANALAISRLGRDWRRTTDPEGDREILALFADDPRAPYSIHSFVKHGEVACGKYPGEWFGPSAAARCIQALVNKHESSLRVYSTGDLPDVYEDGFMAAAKPDGETFYPTLLLVCTRLGIDKINQVYEQALISTLQMEHSVGIAGGRPSQSHYFVGVQGQWLFYLDPHHPRPMLPYRENALEYTPEELASCHTRRLRQLHVEDMDPSMLIGFLIKDEDDWDNFKGAVKHVQGKSIITVSPHDPALGMGAERAEAIDEVETLSGSDDDDDTILHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRD6</accession>
    <name>A0ABR3VRD6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="503"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="731" mass="79379" checksum="FBBA60FF5DD9763E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRL9</accession>
    <name>A0ABR3VRL9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="322" mass="34442" checksum="EF9174A03CCAB8B8" modified="2025-10-08" version="1">MNGQNPVAPSLEAFLATTMDAALVVQAAVNNPNLRVPRIGANRLKTSIRSGWVFVYRASGNGAIRRRRDGLNWSDRRAVKGFQLYRELSDDQNTKVSAQDIAQEQAQRQALTPYLGPHIANDQAKRRGLVKKTIVFDINGEKYGIAAYYTVDDVLNGTVQRPRHLATWNGFNVSVNNLLPDFWNQRTLATNPLSQVITIINDGGMALASNGAAWAMAANVPAPVAVNALPQALAPVQAPVPVPAPAPVQAPASVQAPVSVHVPVPIQGLNNAAPPPPPAQVAVNPAPAQNHDPDDIWDPLSVASQAANYDDIWDPLAQSLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRN1</accession>
    <name>A0ABR3VRN1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4993</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="41"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1844141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="427" mass="46249" checksum="A344C3C51A1696B7" modified="2025-10-08" version="1">MLYRGLRLAARAAPRLSLAGTTNTALRQLPLQFQHVRSYADMVIKVPQMAESISEGTLKQWNKAVGDFVEQDEEIATIETDKIDVAVNAPEAGILKELLANEEDTVVVGQELARIELGGDKPATETKEAPKETPKEAEAEAKPEPTKVEAPKPQETAPPAPSAPAAAPAPAPKPASKPAPATAAAEGVPTLGSREERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSALIDFRNKYKDEILKKTGVKLGFMSAFSRAVVLAMRDLPVVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRNAEALDMVGIERTIAELGKKARDGKLTIEDMAGGTFTISNGGVFGSLMGTPIINLPQTAVLGLHAIKDRPVAVNGKIEIRPMMYLALTYDHRLLDGREAVQFLIKVKEYIEDPRKMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0K5</accession>
    <name>A0ABR3V0K5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000725">
        <property type="protein sequence ID" value="KAL1835339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="116" mass="12564" checksum="8ED7DF06A172481D" modified="2025-10-08" version="1">MPKETKGDDVKDVINKLDRFARDPSFVRSLDDYQLQQMFRTLKAIIVKSINSEQATVITTTTYASNPLGTASTNDPVPPPTNPTASSARPDYSISTTAPPPIIYPTAPIDVTPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V283</accession>
    <name>A0ABR3V283_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000695">
        <property type="protein sequence ID" value="KAL1835383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="99" mass="10118" checksum="52AD824851B28A62" modified="2025-10-08" version="1">MATAATTTTTATTIMSAKGVATAAGAIGGIAPPAIENSGDSARPFKINEFTFATRDEAVQRACAIQNNACADAVNRGQVQGKTVPDCNAQETQCRTDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2G4</accession>
    <name>A0ABR3V2G4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Long-chain fatty acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000491">
        <property type="protein sequence ID" value="KAL1835973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="63"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="503"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="638"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="91818" checksum="F9CB51211D1E9BB3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3A7</accession>
    <name>A0ABR3V3A7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000439">
        <property type="protein sequence ID" value="KAL1836263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="710"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="762"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="762"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="808"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="890" mass="97204" checksum="72DC413B03A38E45" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3F4</accession>
    <name>A0ABR3V3F4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coiled-coil domain-containing protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000433">
        <property type="protein sequence ID" value="KAL1836295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
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    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="242"/>
        </location>
    </feature>
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        <location>
            <begin position="294"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        <location>
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        </location>
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            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
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        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="42649" checksum="DB216E30332B1D17" modified="2025-10-08" version="1">MADVRALLRQQRAARRVDHPHATYTDTGKLICAVCREPVRNESLWDTHLRSAGHRQQLQKLSQSSAQNGAARQAGFVDDDDAQSTSHKRKHSASDEDMVGDDGTVPSATAVPRKRTKPDSPISADDAGPSTATPAKKPDSSRPAKPVTPPLRRVSGTPTAGVEIQIPSRPATPGPLGTPKAAAPVGRSPLIPDDATTALQEAVRGTPPPPELPASTTSPITTAAAPSAAAAPTDTAPAAAPAGDIDESEWAAFEADLIHGTTAAQPAPPAVPPTAAASTDAVISAPVLSAAELEAQAKSEEEARARRRERAAAQIEDEREEAARALEAEFEVMEELEARARRLRERREALRAAALSAKTGGGTGEGEAKGGGDGGGDGGKKGGTVDEEEEDDEDEDEDEDDWAGFRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3F7</accession>
    <name>A0ABR3V3F7_HUMIN</name>
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        <recommendedName>
            <fullName evidence="7">UBA domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000435">
        <property type="protein sequence ID" value="KAL1836287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
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        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF7">
        <property type="entry name" value="ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="4">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="206"/>
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        <location>
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        </location>
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        <location>
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        <location>
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        <location>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="74187" checksum="7867F774F9585F58" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3V8</accession>
    <name>A0ABR3V3V8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000417">
        <property type="protein sequence ID" value="KAL1836391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187:SF2">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
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        </location>
    </feature>
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        <location>
            <begin position="1164"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1482"/>
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        </location>
    </feature>
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        <location>
            <begin position="1583"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1667"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
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        </location>
    </feature>
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        <location>
            <begin position="987"/>
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    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        <location>
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        </location>
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        <location>
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        <location>
            <begin position="1405"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1509"/>
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        </location>
    </feature>
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        <location>
            <begin position="1591"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1687"/>
            <end position="1698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1698" mass="184413" checksum="5CB1C6C5383F4EA6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V415</accession>
    <name>A0ABR3V415_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000409">
        <property type="protein sequence ID" value="KAL1836451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF0">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="4">
        <location>
            <begin position="296"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="513" mass="56810" checksum="131DB4155EE45127" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V460</accession>
    <name>A0ABR3V460_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000396">
        <property type="protein sequence ID" value="KAL1836558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="64" mass="7147" checksum="5E5AF8A22860917D" modified="2025-10-08" version="1">MAVINLSLVPRDTVSHLAKRSNWASENSGVVLVFCIVFVVGVGLIGLFIYKKMIARRERKARES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4C0</accession>
    <name>A0ABR3V4C0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000393">
        <property type="protein sequence ID" value="KAL1836585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="93"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="264"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="329"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="676"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1057" mass="114502" checksum="4D9C4AF8993629C5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4F6</accession>
    <name>A0ABR3V4F6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000427">
        <property type="protein sequence ID" value="KAL1836336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="345" mass="37765" checksum="C5B26F90B8FFE496" modified="2025-10-08" version="1">MSQIAPKTSPSASRPYGGRGEFGEEPGEEAAATPRTQPDEPRMPEAFNEEDTEPQGAEYTHETSKGKPGMEKTPSPETDDMNETGEEHKDMEKGKQEEEEEEAGEEDMGETLKTAKPSGEEQEMEESETAGPEPLSEEESTETGRTEETKEPMEEKAPEKQPSYPEQDSFKLEGEKMMAPFKGTEATDSAASQAGDTESSAPGMETTEKGATEAAPEGQEEPEVQPGETPAEETEAPGVEAETKDLTEAPETEQGLEEGEQKPMKEGMTEEKEEEKPVTEAIPKPIEEGKEEETTTEAIPEPMKEGMTEEKEEKPTTEAIPEPMKEGMTEEKEEEKPMTEAIPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V538</accession>
    <name>A0ABR3V538_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000355">
        <property type="protein sequence ID" value="KAL1836877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="195"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="43886" checksum="CDCFF14C2FC99724" modified="2025-10-08" version="1">MASIPKPGPANLRPGAGLDEWLEEAKQCHYLPENVMKQLCEMVKEVLMEESNIQPVVTPVTICGDIHGQFYDLLELFRVAGGMPGESNVQAPMTATTVIDAHDINPLFPDFSHLKELKKGKTPDAIREGDVATDSAADGEEGSTHKPPPADGAAQSVDTRFVFLGDFVDRGYFSLETFTLLMCLKAKYPDRIVLVRGNHESRQITQVYGFYEECQQKYGNASVWKACCQVFDFLVLAAIVDGSVLCVHGGLSPEIRTIDQVRVVARAQEIPHEGAFCDLVWSDPDDIETWAVSPRGAGWLFGHKVATEFNHVNGLTTIARAHQLVNEGYKYHFAEKSVVTVWSAPNYCYRCGNVASIMTVTGTSPDNPTANTKFSIFSAVPDDQRHIPGGRRGAGDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5F4</accession>
    <name>A0ABR3V5F4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_4413</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000341">
        <property type="protein sequence ID" value="KAL1836993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="74"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1836993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="418" mass="46551" checksum="79D88DA68748DC63" modified="2025-10-08" version="1">MAVSPLVAPAPTSPFKRQPSAVASGSSTGGTPLPSNVAPTSHPQQSHSLVRHGPTGPLTLDPIEQLNEDEKRKYVKGKKLGEGTYANVYLGHARHDPSILVAIKKIKVQQQYQDGMAPDAVRELKYLRELHHPNIISLLSVFSSKDQNLNLVLEYLPLGDLEMLIRDVDRVRYGAGDIKAWMGMLARAVWFCHDNFVLHRDIKPNNLLIAADGEVKLADFGLARSFADPGRRMTANVITRWYRPPELLFGARHYGAAVDMWSVGMVFAELIIRAPFLAGNTEVEQIALICKHIGTPTEEVWPGVTRLREYTVPSEVVPVWPKEAYMGRFGAVGADGVDLLVKTLALDPKKRISAREMLEHRWWRTDPKPTRKEDLPRKSAGAEDKMGADLKRRPGMVEDESAPRGQRVARKLDFGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5H7</accession>
    <name>A0ABR3V5H7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000341">
        <property type="protein sequence ID" value="KAL1836990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="316"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1123"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1236"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="723"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1375"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1375"/>
            <end position="1385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1479" mass="166147" checksum="CFDE2E617CA319B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5J1</accession>
    <name>A0ABR3V5J1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000337">
        <property type="protein sequence ID" value="KAL1837024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="59" mass="6905" checksum="DBB8FE79A4AEDD86" modified="2025-10-08" version="1">MKGAVLKLDLEGHQHYLPCEHLPPPEIILVDDSLRRAVLTGRRSRRTRLLYHDTYAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5J2</accession>
    <name>A0ABR3V5J2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000336">
        <property type="protein sequence ID" value="KAL1837034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="10">
        <location>
            <begin position="221"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="518" mass="56678" checksum="CFD5E8F6AF03366E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V643</accession>
    <name>A0ABR3V643_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000365">
        <property type="protein sequence ID" value="KAL1836793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF14">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="63643" checksum="B7F8B9FE29881B99" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V677</accession>
    <name>A0ABR3V677_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000313">
        <property type="protein sequence ID" value="KAL1837253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="551" mass="60603" checksum="FD75E3332F522980" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6C6</accession>
    <name>A0ABR3V6C6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000310">
        <property type="protein sequence ID" value="KAL1837290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="665" mass="69919" checksum="1B78CFBE0BF4E821" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6M9</accession>
    <name>A0ABR3V6M9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000297">
        <property type="protein sequence ID" value="KAL1837412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="7">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="576" mass="63176" checksum="781331A5522FB719" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6P5</accession>
    <name>A0ABR3V6P5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000297">
        <property type="protein sequence ID" value="KAL1837410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046577603" description="Peptidyl-tRNA hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32337" checksum="A48BDD0FDC430AEC" modified="2025-10-08" version="1">MRFSTAALLALPVLASAAESPFQQYKAKFQNFLSNLGASAPLAVEKTEDAVKTQKEIKTTPVEPKKITTLTLANWKDVLYEPVQADATQPEQWLVLVSGRNNTCFGKCDRIDQAWNASALAFASLPSASALHLGYVNCDDDRVLCNVWSAATGVLWLLDIPGPAPAPVEIRMRRMNTTTVTTEDIVEAYKEAINPPPAVEEETAEGGEAEGQVQKKGRWHRYSPDGYFHPFDGKLAKAGLLVPVAYVFWALNAIPSWGMMLIVSFMSRSMMNRRMSNLDAPAGAPRTGAAPRPAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6T1</accession>
    <name>A0ABR3V6T1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000310">
        <property type="protein sequence ID" value="KAL1837287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="636" mass="73246" checksum="0AD9DE8107129AEB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7C5</accession>
    <name>A0ABR3V7C5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000290">
        <property type="protein sequence ID" value="KAL1837482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="52"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="412" mass="44314" checksum="10A70C56240BCE26" modified="2025-10-08" version="1">MGQIRGRSDHSHDHGHSHGHSHGLGHHHHHHHDNVYLTSKNKSDAGVRITRIGLYSNLGMAIAKGAGGYAFNSQSMIADAWHSLTDLASDFLTLATVSWSLRPPTKLFPQGFGKVESLGSLGVSSMLLFGGLFMCLGSCQSLYAHLFLDADAAKALLEHGHGHHHHHHHHGGHGHDDHGGAPSLHAAWLAAGTVAIKEWLYHATMKVARERKSSVLASNAVHHRVDSLTGIVALVAILGANLVRDATWLDPVGGLFISLLVIRAGAANTLSALYELADKSIDDEVRDAVAKQVGKAMDELSVSSAGGGVNALEVELRDVMGVKSGQNYLVDIELAVPGDWTVELVRRVEEAARARVGAKVRGVRRLRVRFVPKTADELDEFVPGDLSQRSSPEPEEEEEESNGHGHTKGKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7V3</accession>
    <name>A0ABR3V7V3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_3490</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000269">
        <property type="protein sequence ID" value="KAL1837715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1837715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="435" mass="44747" checksum="80C52BC80E341C23" modified="2025-10-08" version="1">MSVQDAVDASEHYEVYNTDDIPSLCTIIIDTNPRAWAALSDVLPISKAIANILVFVNAHLAFSNSNQVALLAAHTNRAVWLYPSPPTPAQSSHNGSNGRSDASSKHAHSSANKYPQFARIESSLLTSIRALIDDTTDSDISSTTTQVAGALTLALTHINKTALSFTAPTATTAAGASGTSGITTGTSGPAPVVTTSTSAGGLAGLHARILILSVSDSAPAQYIPTMNAVFAAAHARIAIDTLSLRGRATFLEQASFITNGTFIRAQEPRGLLQYLMFGFGSGSAPRNAAAAAASDATAGPSAAGKPKTITTGGKHHHHHHHHHKTGRLPPGASVAELLVTPSADAVDFRAACFCHRSVVDTGFVCSVCLSIFCEVPDGAECLTCGTKLALGSYGKRPVVAPWPKRAAGGAAGSAGSEVGGSPDQAKKEKRKTGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Y5</accession>
    <name>A0ABR3V7Y5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000283">
        <property type="protein sequence ID" value="KAL1837551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="65969" checksum="9F3102966B565561" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8B4</accession>
    <name>A0ABR3V8B4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prephenate dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000244">
        <property type="protein sequence ID" value="KAL1838018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="86388" checksum="45A1C734CCFA691F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8I0</accession>
    <name>A0ABR3V8I0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000235">
        <property type="protein sequence ID" value="KAL1838139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047483379" evidence="3">
        <location>
            <begin position="22"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="355" mass="37745" checksum="29A29BCDD89E693B" modified="2025-10-08" version="1">MLASGFVSKAAWLLLLGTALAAPPPKDAADQADAAIQTTTAAAAAAAETPTATAADQTDDADVAACHNTDGPFKPFCLPKANDVIIPGTTYYITWDPTFFPASNTTLKILGFYATPSSRLSTSPTTPDHPPDDKSNPASPGGQHEAFSSDNIDSGWGFWQWRPDAQLLKRPKLKAANITLRIVALPPAGSEGGGGGGTAQWLTGPTVLLKYKDKAPPPETPGQPHKHIGEGGKYDRVRGGGGSAAGDRELYVVLPLVFGVIALFVVMTIFCNRDARRIDLGDVVRSSRRLRRLDGGSRRNAAGARGGRAARDAEESIHLMEHHGPGGQQEDDWDAGWGEHEGRGRVFERVDRKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8K3</accession>
    <name>A0ABR3V8K3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000267">
        <property type="protein sequence ID" value="KAL1837736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="177"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="407"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="649"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="733"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1837736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="821" mass="88384" checksum="ABF746DCAC3FD6F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8Q4</accession>
    <name>A0ABR3V8Q4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000230">
        <property type="protein sequence ID" value="KAL1838209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="92" mass="10432" checksum="4FEA82AC2FE6BFA7" modified="2025-10-08" version="1">MTRAQQTISIALLVSSLYLSLYLELIPLPAAVQRDIVPVLPFWFLVSFGAWLLFRLGWGMLTFRDTPEAYAELMEEIKMAKADLRAKGVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8T7</accession>
    <name>A0ABR3V8T7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Endoplasmic oxidoreductin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_3022</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000237">
        <property type="protein sequence ID" value="KAL1838117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046617587" description="Endoplasmic oxidoreductin-1" evidence="17">
        <location>
            <begin position="22"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="538"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1838117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="71527" checksum="FB441B0E2C65F03D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8V9</accession>
    <name>A0ABR3V8V9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000241">
        <property type="protein sequence ID" value="KAL1838060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="102" mass="11036" checksum="0BAD5CA4349F811C" modified="2025-10-08" version="1">MAIHTSTTTTVTMGNNLSLEEPFADTSGAELADFDVFNDIVMAIAWAGSLYAIGMIWCTVGLLRRWNSDRDLNLISVAAAILISTGWPVVLIYYAMSGGMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8Z3</accession>
    <name>A0ABR3V8Z3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000223">
        <property type="protein sequence ID" value="KAL1838304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="461"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="548" mass="61385" checksum="120D1051C5C93D83" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V992</accession>
    <name>A0ABR3V992_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000217">
        <property type="protein sequence ID" value="KAL1838395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="173" mass="19224" checksum="36232BE331BABC36" modified="2025-10-08" version="1">MTGLDPDTDAIIEISCLITDGQLNLLDDSGWGTVVHQTKERMDQMDEWCMRTHGESGLTAAVIESKVTPEDAADGLLAYIQKYVPEEGVGILAGNSVHADRAFLSKGPYKKVLDHLHYRILDVSSIKEAARRWCPHVASAAPRKKGLHQARDDILESIEEARYYKSAIFQKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9I7</accession>
    <name>A0ABR3V9I7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000215">
        <property type="protein sequence ID" value="KAL1838430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="222" mass="25217" checksum="1833BE433F2FFF72" modified="2025-10-08" version="1">MSVMLQTPSRASTASSSSFQPISRQNTMSSYDGSRSARQSKRYSMSALYMSMSANETDLVIEDDLAKAQKTLRELKAKISSQSKKNFVLEKDVRYLDSRIALLIQNRMALEEVRVNFNPVACCCCSSYADILQQHEVASHLEEAAELQEGTFPNDDKTQKYGNLMFLLQSEPRHIAHLCRLVNMSEIDSLLQTVMFTIYGNQYESREEHLLLTMFQVSSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9P1</accession>
    <name>A0ABR3V9P1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">VTJ49DRAFT_2977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000234">
        <property type="protein sequence ID" value="KAL1838151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="219" mass="23761" checksum="98E6BED90ABCD451" modified="2025-10-08" version="1">MNDPMQSPDQNGAAPASGAIDIHEPFTRGQRIQQLSAVDKDITSLLVHLSSALRALATPPTTFAPPAVHNIYLDGDNNDVTIADAEQPHPLEAFLTAQSAFFTTIDRIDKQLTRQILALEEAGIVTLRSAAEPQGGEQPPQQQQQQQTKSAAASTLPVTLEPDGMGRYGQLEVGQLNLASSTVERDFEAELWKRAMGNLVRILEAQGIQVQRRGDAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9R7</accession>
    <name>A0ABR3V9R7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000236">
        <property type="protein sequence ID" value="KAL1838126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="639" mass="70649" checksum="C5661F677A2FF8A2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAA1</accession>
    <name>A0ABR3VAA1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000203">
        <property type="protein sequence ID" value="KAL1838627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="486" mass="53891" checksum="E924762CDC047832" modified="2025-10-08" version="1">MAMLTFDIAPRAALAAPTEPEVIQTQSLVIVVASLLSILGAGWIIASFATFSSLRTFRHHLILGLAISDFIMALNFLSSSSMNVSGRWIGAPEQAGFCSFNGFMTQLFVIQTDYWVLIIALCTYFVLADHKRASSWAMDHLWLVWIVPWVLSVTWASIGMGVTGYGDIGAWCWFTSDEVRLFVNFVPRWAIISIMFAMYVRLAFILYGAHRRMTSLDESSGNPSGACSRQRDTHGHSSNQNNNTDTTPYRHTQKLKKLARLMLFYPLAYAAVWSLPTTIRIYQTIKGEPAPWQVQTLDKACIVIQGLVDAVIYGATEGSLSSWRNLLWPRKFPGIAASGSGSGADAGPGVRATVPAAADDDFQYFSGRGQVRTYYIHDDQPDLGCLTNDGRWTVDEYRCGVFFATRLTNGDISWNSSFLLEAQGSGPCGYDYYDRGTFNCGSGINATIFWRLIDAPPPPGAEPLEIHWYGASEKGKWAYLGWKTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAC5</accession>
    <name>A0ABR3VAC5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="469" mass="50306" checksum="563E87D01014BD38" modified="2025-10-08" version="1">MSTEATKTPPAPESPTTARPLEMDDDDVQETGAPSPEDAARSNATTTTGTTTTSAAAGSDEVPPPKPPRPLTEEQKKQQTLKEAFPTVDDAVIRAVLRASGGRIEAAFNALLEMTDPDAVAREQSQEEQPPPQPPRPNAPQSAGVTGGTPLSQLEADELYARQLAEHYENVGAYEARTSNRGQHGYRGGPGAGGVRPPRRDDSQEREHNFIDDDLPVIKESLRKGFIETQTKVNAWFNNLKKKIDETFDEEDEDERNRRNQAGGSFLGRPTRDQARRSADYDRYDADPELLSDDFAGMKFHSDGTPVRDQRPYGGSNPNLFKPPPPAPSKSPRPGEGRKAVSFRDTVEDIDAYQAAHRAAFGPGSGRASPGTGTGSGGAAPATAKSSKWQPLSPVDPNPMAETENDPFSLGDSDDERDMGKDRPGTSGGIKMEDTERLKQATADAMAESLVEDKDKASPAGGSSKDGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB98</accession>
    <name>A0ABR3VB98_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000174">
        <property type="protein sequence ID" value="KAL1839114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="220" mass="23574" checksum="713B83658AEF515E" modified="2025-10-08" version="1">MPEKRSNASTSSMEGDSQDLHLQSKLRTIRMADASGAGAGLLALLTGMAVMGAAGDVLRVYEETHLPSEFWLPLWPEEMNSAPTIALVVAGAVVALANVVGLAFHHVGALRAQTSLHQILTFLTPLLGFIASLAAISVYYAADASDAHDTVLSWTCRWRDVPMSQAPHWGPLCAQSRAALYLAVMLVPLEAAALALAGVRARVVRYTERYLDARKTPVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBF9</accession>
    <name>A0ABR3VBF9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000183">
        <property type="protein sequence ID" value="KAL1838960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="266"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="606"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <end position="35"/>
        </location>
    </feature>
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            <end position="113"/>
        </location>
    </feature>
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            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
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            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
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        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
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            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
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        <location>
            <begin position="920"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1017"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1085" mass="117568" checksum="F109418646241CEF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBI7</accession>
    <name>A0ABR3VBI7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">VTJ49DRAFT_2531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="152" mass="16789" checksum="2F84BE94BEDD0991" modified="2025-10-08" version="1">MPTTIELHTFPGEYFPVVVNKVIERAGLKPRVWVAIPGAPWGCHVRRSTSFTAMIDLFAKGLDGQPTDTKGVLDGDASVDGAIIRHPGVMEGYWLSDLAVVFDWESLKITQPGTYCFRVMVVGQKEHEDPKAVCDTVSEWFEALYDTTSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBL0</accession>
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        <recommendedName>
            <fullName evidence="5">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000168">
        <property type="protein sequence ID" value="KAL1839228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN TMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAL1839228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61043" checksum="871859A508275C88" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBQ1</accession>
    <name>A0ABR3VBQ1_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_2053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000185">
        <property type="protein sequence ID" value="KAL1838922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="103"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="215" mass="23980" checksum="37CDD0D01093CE36" modified="2025-10-08" version="1">MAVEHIYPSPDFNREHKHRHNHSHTQHDHHHGPHEHCSRMTLREDGTPWYTAFPEPRSVAPRLDPEDVFRMLQAQARETTPLGSESGSDSGSTSSRDTSVSGVQGEVLIVDARRSDCTGGTIRGAINLPAHSFYPTRGVLYDLCMRAGVKMVVFYCASSHGRGPRCAAWLQDYVGEVGGDLQCRVLSGGIRGWVQAYGGDMIDGFDEKEWQSKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBZ2</accession>
    <name>A0ABR3VBZ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2092</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000187">
        <property type="protein sequence ID" value="KAL1838901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="218"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="700" mass="80137" checksum="AAD550AA126A2D4D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCU5</accession>
    <name>A0ABR3VCU5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="235" mass="27843" checksum="07F44DEED224F46C" modified="2025-10-08" version="1">MMGPAFAPWLREYLEWYSKKNWTWRNLNAVDSPHFLEDLEAKWELGLADEVEDVLRMVIWTGNEDKIGKLLSSGSLFRDNPHLLYTIIRHRQLLFQQYMKFLHEDYFTSCQANIFRIDVVAELAERRLCSDSKRAAINDHFDREMEGLPECSKDFYGGIELWDGILHEAFCNFEPPDGHEDCNPRRRYEALQMSVQQELDKLGFLRDSDKIKLKERRKKWGLPTIQRNSRAAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD56</accession>
    <name>A0ABR3VD56_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="15">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_1256</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000145">
        <property type="protein sequence ID" value="KAL1839691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="19"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1839691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1077" mass="124288" checksum="F57D689A6B24D239" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD87</accession>
    <name>A0ABR3VD87_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="92" mass="10470" checksum="2078F11D37DDE897" modified="2025-10-08" version="1">MVYPTLSRRAANLPRYQSPYAPKYYYQTQFAGITTQTFLKTGVKAGFFGGVALFAVLYYGSGIPRIQTDILQKIPFIGKRFVKEIHPQDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDJ3</accession>
    <name>A0ABR3VDJ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000155">
        <property type="protein sequence ID" value="KAL1839471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="158"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="256"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="372" mass="41258" checksum="E09113F1BBEB2A04" modified="2025-10-08" version="1">MEALSLSHHWTFRIIEDAKRTLYQLSHTPERSLLNLPRRSQVLHSIRGAALRSLVAASRTAAAPARILPAAARIAQHDAASRLVAPHTIRFFTQTPARTSEAERAQEESEQPLEEVQDLKENIAQTEVNVQEAMQEMSPPTSSAEPTEGGQKEIKAGFSAFVRNLVFELTEEHLEKAFSKYGNVMKTFIARDPRGLSKGYGFVQFETEEALKAACDSVNGSFWHGRRITCIPRTDKRDGLSGGPGRHPRSPTEPTSQLFIGNIPYETTDAELNRLFKGIDNLESVRVAVDRTTGWPRGFAHADFTSVEAATEAKRRLEGVVLGDRALRIDYAEGFQKSRDGGSRRDGGGRRDGGRRRESRSSSDDINGDAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDJ4</accession>
    <name>A0ABR3VDJ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000165">
        <property type="protein sequence ID" value="KAL1839298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="501"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="708"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="787"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1098"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1430"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1660"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="796"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1003"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1117"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1446"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1553"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1569"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1581"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1594"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1664"/>
            <end position="1673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1699" mass="185028" checksum="C079CEEC32F76FD6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDN9</accession>
    <name>A0ABR3VDN9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000135">
        <property type="protein sequence ID" value="KAL1839922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="142"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="362" mass="41014" checksum="DA6A9889E1537A1A" modified="2025-10-08" version="1">MPSDKRNQFLDAGDSDDDLDRGSESEDDLQKGGRSAKRRRVDHDDSDDSGSEHLSEGEHSDGEDVDDEGEDGGASLKQDTQQTPDEPAKDSSEDTSQQEKKKKKDKDSSTDSKSPSTDLPGVNKPLTKKNLIVTEAAIRKSGVIYLSRIPPFMKPHKLRSLLEPYGKINRIFLAPEDPAAHSRRVKMGGNKKRNFTEGWVEFVKKKDAKKACDLLNAQIIGGKKGSWYHDDVWCMKYLKGFKWHHLTEQIAAENAERASRMRAEIARSTRENKEFMRNVEKAKVLHGIEAKKAKKRKTPEEEEDPGEDGRAEEHEMDGNGLQEEEQSGKQRRRTFKQIPLATKRKGEEETSEQVQRVLSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE70</accession>
    <name>A0ABR3VE70_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000131">
        <property type="protein sequence ID" value="KAL1840007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="353" mass="39289" checksum="A403630B8162E35C" modified="2025-10-08" version="1">MTTDKKLIVVLGATGNQGGSVARRFIQDPRYRVRAVTRDTSSPKVQELAKLGIELAQADFEDVESLKVVFAGANVIFSNTQYWEAFFRPDCRTDAAAKGISCREYAYIVERRQSKNIADAAATVVDTLDDNGFLVSTLSHAGKSSGGRFKDLYHFDGKAEIFPDYVNETYPKLAAKMSCIYTGFFTTSHRILPGAYFRKHEDGTFEMRFPCKPTTRVPHLDVNHDTGPFVYAVSQMPPGKAYMASSGEYRSFPEWIGAWGKLTGNPARYTEVEIEDMQNEAYDEMLGLEVAIMLRYCDDPGYDGGMELLKAEDLRKAGIDCPMLTLEESLARQDWTAVINKPVWNAPGVAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEA9</accession>
    <name>A0ABR3VEA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="733"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="858" mass="94025" checksum="13570F2AD2546DC2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEC8</accession>
    <name>A0ABR3VEC8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="454" mass="48366" checksum="80637060F9F0E884" modified="2025-10-08" version="1">MAAPSDLEKPSSPSSSSSSGPPSQTDLSISPPPLTKPDAPSTPNHEPPSDDDFTPPDGGPAAWSQVLAGILVNMMAWGLPTTFGVFQLYYRDTLRLPESQIAWIGSLQIFLAFALCTPSGRLADAGYIRSTVAGGGALVVLGTLATSFCRGDYGKIFLAQGLCTGLGLGVMFMPPLAVINSYFVTKRALALAISAMGTGLGSLVFPATIQYLIPRVGFAWAVRVAALEALVLTALAVGLLRPRLRPRKSGPLVEWDAFREMPYALYSVGAFLWFWGLYFGFFYINAYARNVIHFTTTDSVQLLLITNGMSIPSRPVAGYLADRHAGVLNLYIIHTVILGSLIYAWSGVTTRSGMYVFSVFFGLANGAAQGLFPGSLARLTKDPRKLGTRFGMVCTISGFASLAGPPTAGAIIDASGGGRYLWAQVWAGTVIVLAGVMFAWTRVAVTGWKVWVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEH0</accession>
    <name>A0ABR3VEH0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48023" checksum="860399A805B8A1B2" modified="2025-10-08" version="1">MWWFISACSSAIFLLTIVLSIPIAFDVGGRDTGLAYSLSLFLFYFFYSIARLITPERSRVRWFIKNLIALSQWIVIPTLLIWSLNRFSVEAESAGWVSRTFSHITSTHHKTWRDWFFGQDGFVETVALGAWDNTLIYSSPVFQLLEGFCSLLVIQAAGQITRWLVNRGRSDTWVIVFLVLASSIMSGAVYFLWRVIRFPQISNLDATMIGVAMTSVAFLGAFGIASGRGNPIESSLLLAYAVLCVYQIFTDYQPSPAAAAAAAEQAAAQPEFPPLPPIIMASYSTLMHMLSSLPSAVNTSFQFLYAAFQTITPSVIISLTYRIIVFYCATRIIPAVKELGATALMDDPTLEDSGDGANRLIGFLSWFSPSMLIAVYTSLLLQHFSVSSGDDGGWTLRAGDAGGSTWRWVNLVGTAGLYAVELYLGGNEGGAGHWKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF37</accession>
    <name>A0ABR3VF37_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.1</ecNumber>
            <ecNumber evidence="12">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_575</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="12"/>
    <dbReference type="EC" id="2.7.7.18" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000118">
        <property type="protein sequence ID" value="KAL1840322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="14">
        <location>
            <begin position="53"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1840322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="299" mass="33031" checksum="C6D4B28C38B39638" modified="2025-10-08" version="1">MTAGTVDSGTQTPSVLVEQQDPILDATEAPYTFPTHKLKRRQTEPEKTPLVLVACGSFSPITFLHLRMFEMACDFVRFNTDFEVCGGYLSPVSDAYKKVGLAPGHHRVNMCSRAVENSTWLMVDPYETLNRDANGQPQYVPTAKVLQHFDHEINEVLGGIEGTDGQMKKARIALLAGADLVMSMSEPGLWAPKDLDTILGSYGAFIIERSGTDIDQALESLRQYENNIWVINQVIQNDISSTKVRLFLKKDLSVRYLIPDPVVEYIDEHGLFSEGNPYKSRPGTPAATPGPSSQKPAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFH3</accession>
    <name>A0ABR3VFH3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anaphase-promoting complex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28976" checksum="470D9207AD144AD4" modified="2025-10-08" version="1">MRSQVRSQHLLHSKIRHNFHPAKPNNCTATPEVIQPPPPQPLRSRAKMQEPADDDPPANRWTSPQTVSIESTTDSDSSFSLIPPRLRLPLSSSSNSEAPTLVPIDPPEVIIPKSVSHAPILGTSTMNKDGCFTYIHLHQSHHADLLEEFCKDRLPQDDIYVPPDLQPVNPEEEDDVVPDQHAAYGVQKATQKTREPAWRDLGLAELMTRGPSTTTTGAGPTGLMTDGLRSRRLGNEGRLGGLFAWEALRNTGMGTLCIMIRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFM4</accession>
    <name>A0ABR3VFM4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="7">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="695"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="950" mass="105237" checksum="0685B86FD8C2B550" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFS9</accession>
    <name>A0ABR3VFS9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="325"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="401" mass="42939" checksum="021B698A6D4F1D8F" modified="2025-10-08" version="1">MAEKSKKRAKEPAVEPAAAPTSTDAQVKKKEKKSKKEKADKPVVAETDSPVVTADVPAGSNADDKKAKKEKKDGKRKLEDAGAAQADAGVVKGSEEAEPPKKKKKKEGKSEEEATPKEDGQSEKDKKAKKEKKKKDKLKAQMQSVPIQVAAAVEAPKESEAIPPSKPVQNGEQEGTTADQTNEKKKKKKKKDKKKAKSREDAEQADSSVEPAAADESSDAAAPDKKKKKKKDKKSKEKKDQDGDVEMADARTSVEQPQPAAKEDEEKDGKKSKKERKKDKAAKKSKKTSSDSTDAEATTKTETTNTTTTDKAPSSTPTPNLAERWNVSHLDGDAKRKEKFMRLLGGKKAGAAGATGSTAGGDSGARKGFDIGKMSQELEKQFDAGIQMKFGAGGQRKGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGL9</accession>
    <name>A0ABR3VGL9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="457" mass="48425" checksum="11E8B70C5EBF071C" modified="2025-10-08" version="1">MADLLYDLLTPAGSSSQAPDPSSLEYLTTLASQPLSSITSAEPLSLAQSSHSLLLSLQSLSKKSHKQIIESASHHATLSTTLPTLAASTADLRNAIPKLDAEAVRFSTNYSKSGDSEVLARRKKALLLSRNVERLVDVLELPTLLSSAVSAAPANHASALDLNGHIRRLRSIYPKSPLVASIAAQADEAMHTMAANLILSLKAPGLKLAASLRTISWLRRVLPDLEAEISATASSAPAGAGAAPGNGAGKGLEAQERVLGALFLVCRLATLATMLDALDPLRELADQERQRQKAIGSGNAWSGGQQTERYLKRYIEIFREQSFAIVSMFRSIFPAATAATSDGLATGAAGAAAQTNDPLEPLPSALATFPLHLVDMLLDTLREYLPTVKDQAARDSLLTQVLYCAGSLGRLGGDFGLFLATLDIGAEAEEEWVEVVKRHRALAGRLESIVGEQKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGQ6</accession>
    <name>A0ABR3VGQ6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000091">
        <property type="protein sequence ID" value="KAL1840995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="398" mass="42960" checksum="91EBCA598462B980" modified="2025-10-08" version="1">MHYLRLCRPPEIYPGRDQPTLKLVLTITTDLSDSFLSPPNPVPLSILGAYTETDSNQNQRLVPVPLTPSPPPVWRAGMRVLKLDLPLPTSTNPKKSMVLDTIQIRPTDIGLTALSTGDVLPGDKGLIMPVYSDMPRLGGPGALTTPQTCFRSLRIEPYPRWAVTSPQQRQQQQQSLLQIEEDLGESIARHVWDSGVVMVSLLTDLCLGGGSHNPRGLPLFRDLLMTPPDPDRVRGLNILELGCGVGVVGIGLAKILSLRHTATTTTTTLGGEQNAPAPHILITDLPEADEKARTNIARQKRGHTTSSSSDAPMAASASPELGSLDFESLDWTDGQRGVFGEKAGSRAWDLVVVCDCTYNTDTIPSLVGTLSAVHQMSAEKIPVLQAHSKSKDDVLDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGS4</accession>
    <name>A0ABR3VGS4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4976</name>
        <name evidence="6" type="ORF">VTJ49DRAFT_7533</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000090">
        <property type="protein sequence ID" value="KAL1841017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21025" checksum="1008559538928605" modified="2025-10-08" version="1">MAQNATQAAKTAYRTFRELHGVVVSAGLMDKTVKVRVGGQKWNSFVKKFFDDPKTHLVHDPNNSLRLGDVVAITPGWRVSKSKRHVVKHIISPGSGVPIDKRPPIPTEEERLAEREADRAAKAERRKYRKAAEEAERKIGIAELVLRKARREFALRARLLGVDVTLPEFGTAEGKQGEGEGAEGEGTVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGU1</accession>
    <name>A0ABR3VGU1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_177</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="342" mass="39237" checksum="F5BDEABB60482BC5" modified="2025-10-08" version="1">MASLFENLPVPTLDRPFGVHLWPIFSKAFEKVVGYPAEDFRFVPGVTPMSTLKETSIFIVFYYIVILGGRELMRNREPFKLRTFFLIHNFYLTAISGILLALFIEQILPTVVRHGIFHAICHAEGGWTQPMVVLYYLNYLTKYLELLDTCFLFLKKKPLTFLHCYHHGATALLCYTQLIGSTSVSWVVISLNLMVHVVMYWYYFQSARGIKIWWKEWITRLQIIQFIIDLGFVYFASYTYFTSTYWPWLPNAGKCAGEEFAAISGIVILSSYLLLFISFYFATYKKDGKRPSSRKAVRRMSQAPLPDPIHGLEANAHGYATATDAKATGVKTNGSATRSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGY2</accession>
    <name>A0ABR3VGY2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_534</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000116">
        <property type="protein sequence ID" value="KAL1840361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="469"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1840361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="570" mass="63740" checksum="4737A28F8E97BB1A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH68</accession>
    <name>A0ABR3VH68_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="268" mass="28423" checksum="BA81AF05402144F2" modified="2025-10-08" version="1">MLRVNRLKQVLTEAQRPAMGVWQTLPGANISRVLARSGVDWVLVDCEHGNIDDAAMHEAVPAIAAMGVSPIVRLPDFQPWMVKRALDTGAHGILIPLIRTVEEVKAVVEAAKFPPLGRRGFGSPFAPQGFPSASGLTLTEYLQQANDSLLTMVQIETREALEAVEDIAQLVDVVFVGPFDLGNNIGRPIVGSEMHPELSEAIERIRVATVAAGAKAGIYSTSGVQAKKFADQGFHMISVATDYTVLGAAVADALVAARGEGTESTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHE2</accession>
    <name>A0ABR3VHE2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="336" mass="36104" checksum="D6B94AFAAA07D58E" modified="2025-10-08" version="1">MSLPAEIKAIVVTKPGHAELQTVPLPSLPDDYILVRTHAVALNPTDWKHRDLVPGTVGTRVGCDYSGVVVKVGPKTDKQFTPGDRVCGFIHGSNKLRLEDGAFADYVIAKAGLQIKIPENLSFVQAATLGVGISTVAQGLYQALSLPLPGTPQAAATRSPRPEILIYGGSTATGLLGIQFAKLSGYRVATTCSPANFDYLKSLGADGVFDYRSPDVADQIRAWSADAENLLTLAWDCISLDASAKICAAALSRTQPGHYRALLKVADEVVKSVNEKVDVGYTLAYTMIGEPFEKGVRKEAVPEDYEFGKMFWELARGLLERGEVKPARTEVLSGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHH8</accession>
    <name>A0ABR3VHH8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="401" mass="42198" checksum="FFA1B3FF406560AD" modified="2025-10-08" version="1">MAAKTPLLIIIPIACNYIALLLVCMVLFGGFNGSLLQVHWLKITITDFSLPPITASSTYLAALTTFTNTDYIGTPLSSTSLNLPSSTTTHLLTECATYPSGAIDCAPPSYGFRFSPSRHLNLGATSLTLSGGDLTSSLTAYARASRWMSAAFIFSAISFLLTPVEALLISRAWAAFSSGLTSLVLLAGTIAGGAVGARVARAFNDRLSEQNGVMTASLGAAPIALGVVGSVLAVVACVVYVAAHRVMKRRNARVESSLFGDVKFDGGGSEYHGAAAVVAAEAGKSGLFPSVTRRHKYVQIGQQGKLAQLQEQERLQQLQQQQQHRSRSSSPDLNPPRRPDEDWAAPDEYTRAGAGAVRSAPGPEGVKTSSGPSAGIPLVALGANRPTRDLNTAYEPYSNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHJ5</accession>
    <name>A0ABR3VHJ5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000091">
        <property type="protein sequence ID" value="KAL1840992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="163" mass="18915" checksum="CF503361B9F0706E" modified="2025-10-08" version="1">MGPNYEPGVSTIAMYFPKRTSLVIQGEILSPTPYVELRITPYHRDFEALTHFESYARPYIMARVQLLFHGDQFDGMPVPITRYYPFLKGTTTVRAEDVTMVGTALSMVFAWHDLRIIRQGWFRLQVTFLMCHSGGGYQPYAVDEEEMMTIDVGEEFYVRPAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHL5</accession>
    <name>A0ABR3VHL5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000094">
        <property type="protein sequence ID" value="KAL1840926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="241" mass="25715" checksum="BF3A1D82A264F7C4" modified="2025-10-08" version="1">MSEQASTTVVNGDSPHSNTLRHLLTIPAVQDGVRAFNNSPVGRVTTQLGTSAYKLVPAPLLSLMEKPIAYVTPYVTPYAQRVDEIGDQTLTRVVERYPVVKKPAPELLADAREAVYKPVRHVTEVYHSVYERESTNGNGGAATGEKAATGPAAKAHAAVVTGKAAVTTATIVSVEGAIMALREALRWGEGSRVAGTIKTIIDKLEKAALRQRGELSPTPSTTDGEQEKQEERDTTLKAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI00</accession>
    <name>A0ABR3VI00_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="436" mass="45377" checksum="B79462D26B3DC7FA" modified="2025-10-08" version="1">MPPATPAPPRFVIKRPSTQQAQGQTPTPSFARGSGQFQTTPRFTVSTPRPTPGPAGLNITTPALAFKSSTIRRTRATQEIIEDSSPVSPEHGSPSASPIKRDSLPEPIDFDSSLVQQSPGAVSQGGRSAKRRRISIASDDGTDPIVSSQPPEASDLGSLPDATGDCIASYHTDSEIEDNVGDEHDNDDIAADISPTQSIPSPQHHLHDHRDPPSANSDDDEPILTHPKRPKPFPTFRTPAPAAVPDHHAPRFVKRHDPAGESIPGPDGANAAAVAYLTADLFSPPRPARRHKAGTADRYLAGGLAAELRDWLVEAKGGVDGEGEVKAASEVLGVCSPISGAVKVVVDEVSGASLGLTLVAGRLVVDGDDSGAEKRVRMMLAGDGEVDGLGAGVGGGNAGGVRPGAVVAVAPPVWDIELGERWAVASRWKIVGPCHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ45</accession>
    <name>A0ABR3VJ45_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000093">
        <property type="protein sequence ID" value="KAL1840946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="381" mass="43561" checksum="7E6B1CF47FAB00C8" modified="2025-10-08" version="1">MPSQFFPARSSRHRVACFALYRALLRTAQRVPLPDDLTTSSPLVGPNPTQHPIRTLIRNAFRRNRKDTSPRLVVSALKNGYRFLTLLTRAAETSEPPNPERASVLAFLRRNQDRVLQIKAQLAAKAEEWKQGSTAPIPDRQTIIKRVSPEGVWPPVYAPAIPVRPLSMFRDGIRRPPVLGHAMGVPFLRFKKPQPRFLERVLRQKAMRRHKRIGIITALQEEGMADAQEEDLWEEQVERLIAEANKRRKGRVGVGRQERVKREPTYVDSLKEVIWNLVDLTSKEHEDLVARGRAMWQIVLAEREQALEEEKERLERLGRGGEEPKLRDWKRPLRLSTRPREKKKKRVKMMMVKAGVEKGTPGDGGQTSTVGASGETPPPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJG0</accession>
    <name>A0ABR3VJG0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="303"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="562"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="624" mass="67045" checksum="FBAAC821FF922740" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJY8</accession>
    <name>A0ABR3VJY8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="428" mass="46168" checksum="94C3213D794B381F" modified="2025-10-08" version="1">MAPSQAGHVPTLDNLIKSFNDRPLEATIDSLIFLLKRRQIKGDDCAKATAHILRQVVAKSKWTNVNQLLEKVRSDGTRLAQAAPLEPVIGNVVRRVLGLIRDEAAEDRNADDLASETASDIQDIQSLAPGAPPPQPLQRTTTAQMRPTLASLPSNLLVSNSMFNLLSVAEPTGSPITGASTPMSSALHASVHALRSEVMDGIEEILDEISQADDQIAGFADIQIHPGDYVLAYQPTKTVERFLIKAASKRRFTLLLAGLQTPDPSAEPPYAALRKRLAAAGVQTINLASNGLMAYIPRVNKVIFGAKAVYQNGGLLVDSGCCVAAQAAHEYLKPVIALCPVYKFTPEDPSNEVVRGELGDPSSYVSYANGPAVDLLDIENTVTDYIPPELVDVYLTNLGPQTRHHLASILADHYKTEDIAFSLQLDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJZ6</accession>
    <name>A0ABR3VJZ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dicer-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_6722</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000067">
        <property type="protein sequence ID" value="KAL1841683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="69"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="418"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="13">
        <location>
            <begin position="616"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="973"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1270"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1279"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1841683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1501" mass="167018" checksum="1A3414C25D6B96D3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKE9</accession>
    <name>A0ABR3VKE9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000077">
        <property type="protein sequence ID" value="KAL1841381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="199" mass="21962" checksum="F0D7454B0303EF30" modified="2025-10-08" version="1">MAFIIKTRGVERGWARRHFPAAVTFSLSHPSSPRGSQKVEPALSRESSQRLDPASLLPKQKSPLEPTQCPTRTADSSNQILLLKQSVRALKSSFGPSLVSPPFPRTTNQSPNRPLHCSSGRASERACPSPNNFHQINAHLQSSRRPSTSQSNKDCCPKLDVIRDIRRIAYFVSNQSRGASFRFTKRASTSLATVNNPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL17</accession>
    <name>A0ABR3VL17_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="8">
        <location>
            <begin position="47"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="7">
        <location>
            <begin position="383"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="9">
        <location>
            <begin position="568"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="795" mass="89501" checksum="1CF059FC5A325A03" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLF7</accession>
    <name>A0ABR3VLF7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="776"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1016" mass="110635" checksum="90C0C84217BC9153" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLG2</accession>
    <name>A0ABR3VLG2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="8">
        <location>
            <begin position="286"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="568" mass="62167" checksum="D3808963514A488A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLG9</accession>
    <name>A0ABR3VLG9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000040">
        <property type="protein sequence ID" value="KAL1842542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23952">
        <property type="entry name" value="Utp17_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="351"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="608"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="892"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="963" mass="104695" checksum="E2658C11BEDD6B73" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLS7</accession>
    <name>A0ABR3VLS7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="43"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="415" mass="45886" checksum="AB59E6063443317A" modified="2025-10-08" version="1">MAPEEVPILRPGTAPTAEDADLAFTANTPNTASKPRCQDGELPINIGHRGYNAAYPENTMAAFQGAIAAGAHALETDLHLSRDGVVVLSHDATLKRCFGLDKRVAGCDWVELQTLRTLRAPHEGMPRLADLLRWLAQPELDHIWILLDVKTDDDPEEMLTAVAATLDRVPPPPGCGPWFARVAIGCWNDQYMTLTRSLLPNHPIFLIAFSVLPALKYLDTTPRASSSSDFNSDSDSDSDPRDDQIHFNIYQPALVGPLGALFRRLAKQRGRRVLAWTVNDERWMEWCVRVGVDGVVTDEVARFARVRGPDSQAMDGGKEEEEEVVLMDEAMDEVLDGKDGKDDEAKGKGEGKGTVVIRSRPGWRLYVKAGLLQVGAMLLALVWRKGFWHKSPVRKKMRRVLGRAVVVAARTDKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLW3</accession>
    <name>A0ABR3VLW3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="6">
        <location>
            <begin position="185"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="7">
        <location>
            <begin position="347"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="8">
        <location>
            <begin position="503"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="643" mass="69498" checksum="9E52BAF92272E98F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLY7</accession>
    <name>A0ABR3VLY7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-keto-steroid reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3698</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51409" checksum="FD854119E3120B64" modified="2025-10-08" version="1">MFVLVTGGNSGIGFGICERLIDEYLTTRSLTSHLVLIPTTRSVKKSRETVDALREHIRKFAFTSPALRNRAGLKYDPRDTTRRVHILSVQIDLCNLLSIRAAARQLVSGTIPGHGKSTDGDDDYFIPLDEVRLPRLDAVIFNAGIGGWYGLNWSKVFHNVFTAGLISAATWPTFKGGMTGQLVDPIHGSKAEAGTPRIGEVFCANVFGHYLFARRLVPLLARSASTPLPPGRIIWESSVEGSWENLSLDDLEAIKTEAAYESTKRLTDVLALTSTLPSTRSYVQRYLDVSPEDTTPPKIYLVHPGVVQTTLFPLNAFMFFWYNVVLHLVRWLGSPWHPITAYKGACAPVWMALQQQEWLDSVQAERIKWGSSTDFWGECRVKKTEVDGWGWEGKVEELKGSKGDEVKQKRSGRRPGAVDVTEQKLVEFEELGVECWRRMEELRETWEARANAVERAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM79</accession>
    <name>A0ABR3VM79_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="75" mass="8615" checksum="05DE5B126187F16C" modified="2025-10-08" version="1">MCYQLVELYSACRCLYYQHAVDRCPAYGQPGHYIERRTILVGYACSEHSGYAMSDGYDYYPSDYPDSGDKFQSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM91</accession>
    <name>A0ABR3VM91_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="294" mass="32137" checksum="C4A0C997219D5DF1" modified="2025-10-08" version="1">MPICIECRHPVKTLWREGGGGKSGGHNIRLTVCKNCGRFCDKYVEHDFVVMFIDLVLIKPQVYRHLLHNTLMKEKDEFAPSIIRLGILLLLFDVYLTWARIERGQSASVPDPDSPGVSNANTNFGRLAQQPIVFQYMFFLLLCTLSTIAFHGSIRFLTSSRFSPLALLGILPRYSRPNSVSTALLVSSSTKLFPILMVIWEYDVPAAARSLGWAVVANNVEALKILLDCGYGTAALLATAGAVSRWAMGRAVLWAAGLEGVDAGSGATEVAEDGRAFVAMLAYARDWAGRLAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMA8</accession>
    <name>A0ABR3VMA8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6111</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="354" mass="40044" checksum="90B961DF1A4A6538" modified="2025-10-08" version="1">MSSAAKRKMPATSLLQRRVRPRYEPEPESDFEDDVSEAPSEEDAGMPGPSDQDDDDDDDDDDDDDDGLSEDESSASGSEDEDSQAGSSGSEEDSEEEDDEDEDETPHLDASQFSFGALAKAQAALGSTKRKRSGDDAAGKEPKDSGDNDKTTTKPSIKKPPKRSSKHAPVEMSSKFPVSRKRDFLTVTPEIKKREPRDPRFMPLGPGTTSTKPSKATTTVEEIKARKAYAFLDQYRESEMQQLRDAIPKTKDPEAREKLQRALIAMESRKKAQERKDRERAVLEEHRKRERELVRQGKTPYYLKRSERKKLALVEQFKGMKKKEVDKAIERRRKKVAAKEKKLLPRARRGAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMF5</accession>
    <name>A0ABR3VMF5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="106"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="344"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="497" mass="54761" checksum="F1729C9D85B57F37" modified="2025-10-08" version="1">MDRSQSPSALGPRHDAASRIQKPESAADRLAALKARVAAAVGGAKAKGGLNTPLHPALADLSAPVKPADSLRATLGSQRSASDASKGAKGPRGPGPSSAQDGPRVNPYLDMSSSSGTGAPAVKAREPRRLVFNQKGKYIQQANALRRQAALEEMKKRISEQARKAGLEEDRAVEKSYVVEAPPDLEWWDEALVDGKDYSNIPHSLKLTTPDTIVTLYIQHPVAIEPPQDKLAPEPKPMYLTPKEQQKLRRQRRMMELKEKQAKIRLGLEPAPPPKVKKSNLMRVLGEEAVKDPTAVEARVNREIQERFDKHMRANEERKLTKEQRAEKLAQQQAKDAAKGIRVCVFKIGSLANGQHRYKVGINATQNGLGGVCILHPRFCLVIVEGGEHSINNYKKLMLRRIDWTESLPSRERDGPPAAGGAASAAANHDWLRPEDERGQLKDLSSNKCVLIFEGETKAPAFKKWGSKVCETDAEAREFLAQRKMDNFWTQAKNTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN68</accession>
    <name>A0ABR3VN68_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="52"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="151"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="327" mass="35240" checksum="652E19275E172A09" modified="2025-10-08" version="1">MPPSSMDIGLETAPRSITENPPDANAGTTSPDYVSIRSVQGDHTHRRLKSRHIQLIGIGGTIGTALYVQIGKGLLDGGPASLFLAFTLWCTVILAVTLCMAEMVSSLPISSPFIRFAGRYVDEALGFAAGWNFFVFEAVMVPTSPWLTSGSLINVLTVKRYGEVEFWAELGKILLIVGLLAFTLIAMLGGNPLHDRFGFRYWQAPGGPFAELYYSGVLGRFLGFLQCLVQASFTIAGPDYVAMAAGEAVNPRQTLPRAFNAVFYRLTAFFVLGSLAVGVLVPYNNAELVRAYREGAPGAAASPYVMAMDRLKLGASGLPDIVNARWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN77</accession>
    <name>A0ABR3VN77_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="73"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="153"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="397"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="827"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="883"/>
            <end position="1002"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="64"/>
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        </location>
    </feature>
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            <begin position="170"/>
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        </location>
    </feature>
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        <location>
            <begin position="266"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842875.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1099" mass="118668" checksum="2CF6AECA3C86E698" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNQ9</accession>
    <name>A0ABR3VNQ9_HUMIN</name>
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        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_1747</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1843397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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        <location>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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    <sequence length="532" mass="60347" checksum="7B983415B3A61E08" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNW6</accession>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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        <name evidence="8" type="ORF">VTJ49DRAFT_1567</name>
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    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
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        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="99"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="73"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="482" mass="52142" checksum="94D20EDD6E51BEF8" modified="2025-10-08" version="1">MGRNPVLSKQGQPRRSAVSTDAPSRASVVSDDVKLSAADDRNHADVMAGVASSTETPPSLRDTEKQGEIEARGQGDGNARTLIREDGTEYPTGMSLALITLALCLSVFTMALDNSIIATAIPKITDQFQSLPDVGWYASSYLLTTAAFQLLVGRFYTFFSIKLVYLVSLFLFELGSLICGVAQNSVTLIAGRAVAGVGAAGIFSGALTILAHSVPLAKRPIYTGAIGGMYGVASISGPLLGGAFTDHVSWRWCFFINLPVGGVTMAVIAWFFSDPKHRRQPAAASSSSTTEDNDTLWQHIRRFDPWGTLVFMPAVISFLLAVQWGGTTYPWNSWRVILLFCISFVLLLLFIYDQFVQKDLATVPPRIFLQRSVWSSAVFGFFIGGAFIGSTYYLPLWFQAVLDASATRSGIMNLPMLISMVVVSFLAGGLVTLWGYYTPFMIAGSAIAAVGYGLTTTFQPDTGSAAWIGRFLISRMSPQARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNY8</accession>
    <name>A0ABR3VNY8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Minichromosome loss protein Mcl1 middle region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="12"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="418"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="756"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="96969" checksum="D2D947C0483313FF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP70</accession>
    <name>A0ABR3VP70_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="332"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1290" mass="144730" checksum="32BA3BE2A585D41C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPE5</accession>
    <name>A0ABR3VPE5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRM5</name>
        <name evidence="13" type="ORF">VTJ49DRAFT_3347</name>
        <name evidence="12" type="ORF">VTJ49DRAFT_4842</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="145"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="302"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1843033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="495" mass="54881" checksum="400540071C28482A" modified="2025-10-08" version="1">MSHPELQYHVEGEMTVFQVPIVRTGTAALNRALFSKSIGIAAAAVHDNKTIAHYRKALQASKEILQADRVSPICPHPDKTLADQGRKCLLLNPSVKAEVLKDGVQKKDLSVIPYELKLDYDYWSYRDVMASILPEELHDEIPSGFNIAGHVAHLNLRDAYVPYKHLIAEILLDKNPQIRTVINKVDNVGAESEFRTFQYEVLAGPDDMHVTVNEGDCTFEFDYSKVYWNSKLETEHRRLVTLFQPGEVVCDVMAGIGPFAVPAGKKRVFVWANDKNPESFKCLEAAIQKNKVAPFVRPFCEDGRTFIRRAADEVLEASRRGDCAVIPPKVKPPRRSSNSSGRQPSPRRAAPKEERIPIPPTISHFVMNLPASAIEFLPGYRGLYAGHEDLFAPSPSANGRRLPMVHVHCFGPKADDDGPKLDVCERVSKALGVRVRLAREGEDPAAEGVEEEKVGEDGVPEVVVGVHLVRAVAPAKSMYCASFRLPRAVAFAARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQF7</accession>
    <name>A0ABR3VQF7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="7">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UTR4</name>
        <name evidence="8" type="ORF">VTJ49DRAFT_5791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03117">
        <property type="entry name" value="Salvage_MtnC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027511">
        <property type="entry name" value="ENOPH1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1844040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="252" mass="28268" checksum="1D3A31F903B80A80" modified="2025-10-08" version="1">MASLNKQPRIVLLDIDSEGTVCPISFVKDVLFPYALSALPSVLQREWDSPSFRVYRDAFPAEYAASQEALFAHVRDLVARDVKIAYLKSLQGYLWESGYASGELKAPLFPDVAPRIVKWTEEGWGGENQKQEDEEGKKVKVMIYSSGSVPAQKLFFGHTDATPESDLRPRISGWFDTVNAGPKTETESYKRILESGQHIPADEWLFLSDNVREVAAAKEAGMQSFVVERPGNAPLSEEDRAKHRVVRSFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQS0</accession>
    <name>A0ABR3VQS0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="67141" checksum="3E817436814B6795" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQU4</accession>
    <name>A0ABR3VQU4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="433" mass="48299" checksum="45106702A1D565D0" modified="2025-10-08" version="1">MNCDQATMTQEKPSVALPLPLPVPVTASKNEDLLRSAEDVIFIRPLSSGATCTTDLVYCPKVGRVCVRKTLLHGESRRRDAVDFDRDVRTAYRLATVAASGETSLRIPELLAAQSCSGSPRVSLWSLCNGGTLGVFLREAEWNNTAVPEGLALHFLLQVLETLDFMYTATETPMYHTDLHTANLMLHFTGSSGAPDVYVIDFGRTAHADPQPGDFLFLRSGKAPGLDTDMCSEPNPADHVLPFWDMDEVLNLTKRLMLATFPCEGGKLMKDVGAYLEEGRRRSLDDHRSQRKHQRHRRHVKNAKDKETSSTGPCPRLRAAFDALEGLHNLYKKRWMAASKERMSRYKAGKSLLPPPTPPSLKRTIELLQTVTPPLLKKALEGKEYGMFRRMVLEKARRKAESMEEARPGDFGDFGEEGEEEEEDGEEGGVAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR16</accession>
    <name>A0ABR3VR16_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044950">
        <property type="entry name" value="TED6/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35697:SF6">
        <property type="entry name" value="LEUCINE-RICH REPEAT EXTENSIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35697">
        <property type="entry name" value="OS08G0108300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="684" mass="71088" checksum="3D90961063B26FFD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR92</accession>
    <name>A0ABR3VR92_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">White collar 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4927</name>
        <name evidence="8" type="ORF">VTJ49DRAFT_5602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000467">
        <property type="protein sequence ID" value="KAL1836089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="589"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="853"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="926"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1022"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="938"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1844075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1119" mass="115760" checksum="695C550E3AABAFCB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRJ1</accession>
    <name>A0ABR3VRJ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28318" checksum="D2BDBE72CCD1AD6F" modified="2025-10-08" version="1">MAESSSKPRIRIREATQADADTIAAIHFGAFEDSIMDQLMFPGGPSADAKQKFAARIFPRPVTDGEAPPKSQTFVYVAKLLPNDESAGTSGEVVAFAKWRLQAEPLPEEEWKKDQFECTTEVFGEGCDITVINAFIGEMTRMSQRLAKGEAALYLGILACTPSRQRLGAGSALMKWGVDLADRLGLPAWVEASPIGYGLYRKFGYQDVDVLDLNITEKWGVTNTDGSNWGANTAVELKGPAPEGVFRTVILRRPPKATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRS3</accession>
    <name>A0ABR3VRS3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_34</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="203" mass="22539" checksum="58543DADBCE37416" modified="2025-10-08" version="1">MRAHLVQGLVSLCEALDIPDEFLNERMQGVCHSFGTRTEHDDEGGNMGGFAAWFHYLCKAVEPDNSLYQRWYKSAFFLRKHRTQHGGGVTLVMFGPMPAVTARIKAFLEGGGWRDVCFEPIALFDLVLDGLFGETDMTVWRLLDVISGLEEASLPKCLDTKLQIITHPSESFKLPPICEEVGNKRPTRSTSPSCMAGPSISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRV5</accession>
    <name>A0ABR3VRV5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_75</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="301" mass="34060" checksum="06FED23E64DA34C6" modified="2025-10-08" version="1">MAMHPAYAASTAAYATHATNVAPWSQSASGSTAYTYRSILRELKSQDDPQFICVLLDIAYHEKTGTLLIYSELAKGGTFWDLARNPRLSQRRLHPFLVLLLWYDMILGVCELHALDILHRDLKGDNVLITVEISAEANDALLAFQDKRITLSDKRMRALTELLFHNKHRMAVVTDVGLSRDETDPSRSDRTYFGGPEAWTDLISPPELKFGGFQSLMADVYSSAITGRLLCTGQYPPAWDQYNFAPLPAQYSMLQDLVNRCLTLHVPTERPKTFEVAEMLHRLIEVELWKLGPEFQQAIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1P6</accession>
    <name>A0ABR3V1P6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein ECM13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000624">
        <property type="protein sequence ID" value="KAL1835517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33889" checksum="3A258C485338E218" modified="2025-10-08" version="1">MASLLSQQQPTTSTHPRPLGSSPAFTTSPLRPTPVYTKKMSIAQTYFLAHRARAKLSYEAAKSDHNLRLLVGHANLLDSLMLELADAEREQESWFNQSVRGASSHNAPEERHVQWADTIAEEPEHDWHAEDAESDSDSDADSDFDDEEDQDIEMADAVTFQRIHSHAATLYQTFSSKPQQQQQQEDYDMDEYDEEEDEEDFGRLALQRTPSHSRSAVHPAGSTSPSSPPELEADDSEDDSAEDESMPPSPPTAIIQSFPDNAKTHQEEEGAAGIPPTDKASFYEEGFYLPPRNPARLISAISVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1Q3</accession>
    <name>A0ABR3V1Q3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000564">
        <property type="protein sequence ID" value="KAL1835692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045871551" evidence="2">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="206" mass="21181" checksum="79C5983D83A57E69" modified="2025-10-08" version="1">MHLLAGGLFLFAAAAAVSGTPENAAATAPLAEQDGVVPQEQQFYRSQGGAAAVEPDLGTLGGQGFVSHLDCGHEGVPGGDGNDIPPPQSPSGQPPSPPPVDEPAPNNLPPTPTPPYPIRYPSQTAALGTGALVSTGTGIFPLATGRARPSYLLVSEAAPAAGRSKEEYSPGDVNQEALADINPDSPALTLCKTWSTRVMETRDHWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V207</accession>
    <name>A0ABR3V207_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000542">
        <property type="protein sequence ID" value="KAL1835762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="44939" checksum="7FBF0E42F634F8D1" modified="2025-10-08" version="1">MEATRRVLGTPSGVVCAILVIANASNEPESTCPRPFQDPMQTRAPSNGGSNYFKLVQQDFEDLVTSRENAVRTREDSIRDQEAQIQQARQDCQSKAAALVERNNGLDARAAELERREADIGQKETAIAQRETVVKENETALVQRETRITEREATVNSACSIQESLMKKLDDLSQQLQEHRQAVDSKAAEGGRFVALVAERDELKNRVSDLDAKVHRLVGEKDSLLKGLQALREQHDTNLQQVSSERDTLASKIAALESQLTDGATERDALRRKVADLEAQPAPKAASDETRSASGSSDSSRKRQRANSSPDRRSEWEAVIEYVADKLYYELSAMWLKPRFSNNWKEFLEHGRLDVWHCLLTLVQDRDQPCEKHGTKCLYIKIREEGREVKTSFTMQPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V277</accession>
    <name>A0ABR3V277_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000597">
        <property type="protein sequence ID" value="KAL1835586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="360"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="904" mass="99999" checksum="6D52D7EAEE140FFC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2C3</accession>
    <name>A0ABR3V2C3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000520">
        <property type="protein sequence ID" value="KAL1835866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047364917" description="Hydrophobin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10419" checksum="490019EAD9870D52" modified="2025-10-08" version="1">MQFTTIFTLLAAAMTASALPRESVARRHTEDAKVCGNDQATVCCAPQGMIAIGCVIPTVLGGAATCPTNFKTICCEQEEVTQTQYGLVNIAPNAPCLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2F9</accession>
    <name>A0ABR3V2F9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000654">
        <property type="protein sequence ID" value="KAL1835458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="13972" checksum="EFA56406AE4D88D1" modified="2025-10-08" version="1">MSRKGVGLAAFDRSRLTSAQYASHGSNLRSANAQALETQLAVFRSLLQQFAQTHAKDIRSNPTFRAQFARMCAAIGVDPLASSSSSSSGGKAGEGGSIWAQLLGRSVNDFYFELAVRVVEVCGETRGENGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2U6</accession>
    <name>A0ABR3V2U6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore assembly and biogenesis-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000553">
        <property type="protein sequence ID" value="KAL1835726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27266" checksum="F6CD84EE9946FFB9" modified="2025-10-08" version="1">MSRRSGHSSTSKVRFLFYTTLTSSRPDDGCTLHPTAPSHTSILTRDPSCSQTDYLPPDTTLPTTLYTLFLSPSSPLQTALRTLTSAISTLTTHLVPVINALLDRAATLFSSTSPDILALASLLLLTFLAWQLLSLVRRIIAFWTRLVFRLFFWAVIGSVVAMAWQRGVEQTARDAVVVGAKVAGWMVGVAQTWWEEFEKAQEVQGEWRRYQQQQQQQQQYGGGYAGQQRAQGSGWGYYQQGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2V4</accession>
    <name>A0ABR3V2V4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1244</name>
        <name evidence="3" type="ORF">VTJ49DRAFT_5860</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000504">
        <property type="protein sequence ID" value="KAL1835930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000144">
        <property type="protein sequence ID" value="KAL1839707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="8"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="210" mass="21755" checksum="C9D95F8132E1C9C4" modified="2025-10-08" version="1">MSGKLNAKNLQYNRSLPPFLARLRGEADDETRGGPDPILAARRRPVKPRSASEEAEDAPVVVDEQGNVVDGGGVSVGKDGSVTVKEEGDGRKDAKEAEGDNGDGDAAAGSAAPAENLASVGGPRKKRKIARVVGAGDGEEEDREADGDNKKSRGGEKDRDGDKHGRATGKPSSATSRDATKGSDAQAVPAKDKPKKKAKKIKLSFGDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V354</accession>
    <name>A0ABR3V354_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000457">
        <property type="protein sequence ID" value="KAL1836151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="395" mass="41993" checksum="75EF573C976AE41A" modified="2025-10-08" version="1">MATSAALALPAPRSVTAPAGKDGAGAARGEGSSAPVEDTAAEDEPRFYAGRIDYSNGEIHIVWVTEEVRDVGCFMIPAAEAAKPRQAGKKGGGSAVVASRAKRVKIDKDGARIYTRKRYDVWATVYYGPGRGRRRRNYSHQVLTFEEDNNGGATAGVDEPGNGRSGEAEDEDERAEAVAERDQLMLDDAEGGTVATTPSSTVADSPTDASAPSPSTPGTSVPDTSASSTSVPGNSLHRQPPADDDDDLPEWSRKLCGTYTTLPAANQAALKEFLELARPRNAYIDDVTRFRGQICPKAKEDFRADGLGKPGCTRAAHIEMDLEAEDWDRWGFRKVVVEVVASDLQGPVELGDMVVEEEEDGGDEGGEEEGEDEGEVVEDAGVSGNVLEESEASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3A5</accession>
    <name>A0ABR3V3A5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000440">
        <property type="protein sequence ID" value="KAL1836254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046774118" evidence="2">
        <location>
            <begin position="19"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="345" mass="40246" checksum="BB42D9E0B1DD0000" modified="2025-10-08" version="1">MKSAVAFTLALSVSLAHAGINWDVYEYGVVPTFRWSRPFPDDGSEPMGFHIKCRNTASFKAKMYKLKDLAEEPPTGLAPWKEGIERFMAQRDYAGSWDGVDHKDQDREIIVMEWTDVPESVRQWIEQQQRGDGLVPEHKWLFGVFRKPKEEGEKIYNTVRPKPLPKPTPIPGSEQEHGQQQSHTDSQTQQAQQQQEQKTESQAEAAKSPSAEEEEPVPDIPDTEKIVVFPAGAIYENLPLWAAKGSNCERQLHDLSKYKSQAIDHAVLAWPIDHTKPLRDWGKRDITFKVEAMEVEETDDQKKSRQMWERMHRMIKRNDRRQQREERQRARREMEEVKYRVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3M0</accession>
    <name>A0ABR3V3M0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000517">
        <property type="protein sequence ID" value="KAL1835878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1835878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="429" mass="48285" checksum="89C437C16C8D82F1" modified="2025-10-08" version="1">MFAAPWVCQRCVRSLGRIRVSQFIRRASTDSAPRTLPPALLERARRLTREHDQLRTALENDFDSKKAKRVGELSRIAEALKQFEKAKAALGELQALLESDDAEMRELARDDLEATKTQLDESSRNLSVALTPKHPFADMPCLLEIRPGPGGTEGRFFADTIFKMYKLYCANKGYRTRVVQYEASDSDGQTGDEGEVALQEAVLEVQEPGAYGLFRGEAGMHRVQRVPATETKGRTHTSAVAVWVLPSFPENGGTSESEADWDNPESDFYIDPTEVRTETMRARGAGGQHVNKTESAIRLTHVPTGITVSMQDSRSQHRNRDVAWRLLRSRIAQKRREAREEQVRQLRNSVLATHQITRGDKIRTYQYQQDRCTDHRCGLDMHNLPDVLRGGETLDRVMESVRTWLINKDIEAVLADEEAAAVAAAKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3Q6</accession>
    <name>A0ABR3V3Q6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5216</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000417">
        <property type="protein sequence ID" value="KAL1836392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="9">
        <location>
            <begin position="195"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="8">
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            <end position="604"/>
        </location>
    </feature>
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            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="419"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="606" mass="66041" checksum="772D94B1A07C35BF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V440</accession>
    <name>A0ABR3V440_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000455">
        <property type="protein sequence ID" value="KAL1836161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="502"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="822" mass="83909" checksum="1D7E19C4695A9338" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V467</accession>
    <name>A0ABR3V467_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_5458</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAZGSY010000449">
        <property type="protein sequence ID" value="KAL1836191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="381" mass="42908" checksum="0E19C8D26F288A97" modified="2025-10-08" version="1">MEAEVFSDDSPSYSSDQDTVVEGGGDFVDSYRTALIDRIMKSFCASLDSKLALAKASGRSPKVDEGKKEEGQVSTVEDSRYYDEEEAEDEEEHAEAQVGPAPSTIQKDLKKAAQVEMTITSTKREMKKKRFGSFPMSILEKGKFRLAKSERAPREAEGMVPGSGLPPPAPAPAPAEASSPPALRLHIQQDPPCRIQEKRTLQEGFTKDQEKKLRSRKKTHADMNDEDKWREIYTILFPDDDHSSIPSPYYDDSDDEEASGFIGSGEFEDYATFVRREMPTLVRRELEVLFRDEFKDVEERLRPRIAQMVLDLQPKLLDLYKQSQMPLSEYGPQQHEDRALESEPAVTPLLLKRLHCQFGSKMSTSFTYAPPPGVASRMPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4A3</accession>
    <name>A0ABR3V4A3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Common component for nitrate reductase and xanthine dehydrogenase protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cnxH</name>
        <name evidence="5" type="ORF">VTJ49DRAFT_4891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000391">
        <property type="protein sequence ID" value="KAL1836602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="163" mass="17883" checksum="B04C33DD149CD712" modified="2025-10-08" version="1">MMASPDQNHPDSLSEDNCWVALTSSPLEIQSVVDRVRSPQAGAIVLFAGTTRDSFEGKTVVDLRYEAYAPLALRSMLDIACKVKERHGLKGVAMVHRLGVVPVGEESILIAVSSPHRQAAWRAGEEALEECKARVEVWKREEFADGEGVWRANRDGQAGERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4F2</accession>
    <name>A0ABR3V4F2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000386">
        <property type="protein sequence ID" value="KAL1836634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048492">
        <property type="entry name" value="Stu2_CTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="276"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="803"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="671"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="882"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="957" mass="103261" checksum="6880168447701045" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Q2</accession>
    <name>A0ABR3V4Q2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000371">
        <property type="protein sequence ID" value="KAL1836742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="36"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="372" mass="42433" checksum="012D64BE0186C04A" modified="2025-10-08" version="1">MNTTVTQYGPHNQGLFILNPSDPTWERQHGPANLDVVAVHGLNGERIRSWTRKDPETNEETLWLRDMLPQEMPRVRAMTFGYNASVVGNTSVNGIRDNARSLLEALRLLRDNDGSKGRPIVFLGHSLGGIIIKQALCTANIEQRKFGDILTSTRGIVFFGTPHRGTDAAVWGEMVARIKFAAFGKRELNDWFRVLRPDQKDLVNVSEDFRPLATRFAISSFYEENAYPNLKKVIVEKKSAILEMTHEDYCAMPGHHSSIVKFSKKAEDQQRFTLAWRAIERVAKGPDRSTTAEFRAVYREVPETTSGRYAEPRWEPVEVAGRIEAPNGFGKAQLGYSWKGAQNTWDKAQEREKVTTRGRRWEEGEGERRRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5X0</accession>
    <name>A0ABR3V5X0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000375">
        <property type="protein sequence ID" value="KAL1836718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="229" mass="24617" checksum="37ECEA879D3C804F" modified="2025-10-08" version="1">MPFRVAVERFPAYSRSEYALEHIESAAPLARLVREGHGAGWVEVDTGVAGRAEAVFLVDVAVAALTVVAHLDQAQAQAQVGGGGDGVVGGHQGTGGVAAAAVVTEVFEPPPVVYGGPNGSVYSGRSSRASRRREEKERKREMRKQQRQRERGNSTKRAMEQFEIDLESQASDLKAVAREKKDQLPGFLRFLVGVVTVTFKCFIWCATVAFKALFAILSGLAKCCGLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Z7</accession>
    <name>A0ABR3V5Z7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000355">
        <property type="protein sequence ID" value="KAL1836876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="519"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="439"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="606"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="723" mass="74361" checksum="D20558AEC8B5E92C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6E6</accession>
    <name>A0ABR3V6E6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000350">
        <property type="protein sequence ID" value="KAL1836913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="394"/>
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            <begin position="893"/>
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            <begin position="928"/>
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            <begin position="1005"/>
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            <begin position="1030"/>
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            <begin position="1115"/>
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            <begin position="1141"/>
            <end position="1160"/>
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            <begin position="200"/>
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            <begin position="604"/>
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            <begin position="1204"/>
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            <begin position="572"/>
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            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAL1836913.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1487" mass="163978" checksum="CEF86906189F66BC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V6T6_HUMIN</name>
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            <fullName evidence="12">Cyclin-dependent kinase</fullName>
        </recommendedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
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    </comment>
    <comment type="similarity">
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    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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            <begin position="18"/>
            <end position="65"/>
        </location>
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            <end position="230"/>
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    </feature>
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            <end position="513"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="54466" checksum="5381E10322C16EC8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6U1</accession>
    <name>A0ABR3V6U1_HUMIN</name>
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        <recommendedName>
            <fullName evidence="7">DUF1740-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000290">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="124268" checksum="4FDB82198378ED80" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6W2</accession>
    <name>A0ABR3V6W2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_3694</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000287">
        <property type="protein sequence ID" value="KAL1837509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="14">
        <location>
            <begin position="4"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="13">
        <location>
            <begin position="436"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1837509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="768" mass="86049" checksum="7E25B8BB6F1FC760" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6W5</accession>
    <name>A0ABR3V6W5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000288">
        <property type="protein sequence ID" value="KAL1837502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="181" mass="20835" checksum="30EF19987FC91B95" modified="2025-10-08" version="1">MMVRLGSDAGDDGRRHSGLDEALHGDVACRCNQTSGRVREVWRSHRIRQGLRRFAVCRLFQRNVVESPKETLCWMESRLSSQKERATCGRCKRATRRFKREMNRKEKTTGFELMKDRNGREGQEGEEKERNEHLAGVFGPDFAKARTLDQDDELGEIASLAQGIHTVAANERRRLLQVPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V777</accession>
    <name>A0ABR3V777_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000278">
        <property type="protein sequence ID" value="KAL1837619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="410" mass="43855" checksum="905F1AB7CE2BC48A" modified="2025-10-08" version="1">MLENLCTLPLSADLFTQVLHPSQPLLTVGLSSGRVESFRLPSEEDDEGSSSSSGRGLIKSVWSTHRHKGSCRYLAYSHDGEALYSAGTDSVVKHFSPETGIVISKIGLPPRNSSTSATDCPAILHALSPQTILLGTDSGALYVFDLRENGGLNPKPVRKHVPHADYISSITPLPPSAESTSGFPKQWVSTGGTTLAVTDLRAGIVATSEDQEDELLCSAIIPTGLGPKHMRHNAVVAVGTGGGVLTLWDRGSWDDQQERIYVAGGKSKRDGDSLDAIVRVPDELGWGKAVVVGVGDGSLAVIDLKQREVRAVLKHDEIEGVAAVNFDYQNRLISGGGRTVKVWAESGLDEAEDEEDKHGPGAIKRSADSDDDSDEDDSDSEDERPKRQSKKKRRKGKGSQTKTVAFPGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Q3</accession>
    <name>A0ABR3V7Q3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_3372</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000260">
        <property type="protein sequence ID" value="KAL1837825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="142"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="241"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1837825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="35366" checksum="D78B047D1BD48662" modified="2025-10-08" version="1">MSNTVKQAAEAARARTNDVVNTAKSGSVAVAATDFLHTPFMRAALPFINGGISGMVATTVIQPVDMVKVRIQLAGEGKAGGPKATPLSVTREILASGKALDLYTGLSAGLLRQAVYTTARLGFFDTFMARLTRRAKDKGHAVGFAERATAGLSAGGLAAMIGNPADLALIRMQSDGLKPMAERKNYRSVIDALGSIARSEGVTALWAGAAPTVVRAMALNFGQLAFFSEAKAQLKKKTSWGTNAVTLSASAVAGFFASFFSLPFDFVKTRLQKQSRGPDGKLPYNGMADCFAKVARQEGLMRFYRGFGTYYVRIAPHAMVTLIVADYLGFLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8R4</accession>
    <name>A0ABR3V8R4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000233">
        <property type="protein sequence ID" value="KAL1838167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="447" mass="47230" checksum="EED2268D97EC09F3" modified="2025-10-08" version="1">MAATIFRLPITPLPTPAPTANFGRGPVPRFVRRFENGTVTTASPTSSPGPNSAAFNALHTCSSSGDYGSCLASNEAAYCNCNNGMRYLDCVGAAVTGSTDAGVDISDWGAYERGWFQSSCPKPPSNVMAQLEQPSSVQLDLEPVSTVLPTGPISEPPRPGTTATYTPGGELLAGECSSTSYTLLNGGDFVFYAAVVGCDAGRPQCCPWNVAEQDESGVPAENRAIPGEFPNPASAQDSKLDGCPQDYYSISGKCCPKESSSGYYKFTREIAQQTPCFSSLATTENPPPVTAGLSANPTQSNLPTSAVVNLAIAMAFDVEDPAPTLSQAAIIGIGVGSGIAALIIVAASSFLFVRWRRHKKETSRNREPAVGMSNAPDIPDIPDMRQGTTYQSGYHAPVEAQEAAQNANPFYVEDPGAWEAGYQYGSGYHAPASQQPSETDHERYYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8R7</accession>
    <name>A0ABR3V8R7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000259">
        <property type="protein sequence ID" value="KAL1837836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="52776" checksum="C4754A28453463CD" modified="2025-10-08" version="1">MGLERVSAFGNKNFAVVVVKVIAAFGLPCEIIAAILRSLDHPRSLLPALLTCRHFYTSFKESHGVEASIIHRQIDPALLPYAVTVAETSRLPLYPRPAASVRSLLDDLYNSPARLASRSLTLPLNTLRSMSRTYEIIQGLAYDFSRRALQQIPSPKETALLKPGVIHSSDDAKNDQDTESEQGTSKEIPAPGATRSPLSPHEQFRFCRAFYRVELFNMLFRGGEFSEEAVRSWFFSRLPPWELEQLGCAHLFLEMEFASGTSLTTHQPFQLSRGICFVHRVITASDYNTKLKLLQSRDEPDGNINHGYYNQGFISALYSVYDAFYEDDGILDERPDEVLRAELAPIRPSRDDWQEKDRDEDPDWGPFHAWLNQHRKNRVATSVMMYEEAWLRARAYVLWDQERMDNEFPDGFGEQAEHPLKYTDEEYDEMIESFDLRSQIWRRGGSGYWSKGDERQREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V956</accession>
    <name>A0ABR3V956_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000224">
        <property type="protein sequence ID" value="KAL1838295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF15">
        <property type="entry name" value="ACID PHOSPHATASE PHOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045398924" description="Acid phosphatase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39653" checksum="94D14204A453E736" modified="2025-10-08" version="1">MRWLIPSLAGLAGLAAAVPVSIALPGVPPVIKGKAFDRFITIFLENQDYAKVAADSHITDLKRHGILLTRYYAHTHPSQPNYLAAIAGDYFGNNHDDWVRIPENVATIVDVLEDKNISWAGYFEDIPSPGYMGNYSDGSTGTDGWDYVRKHNPFVSFDSITNDGKRLLLIDSFDTFQRAFSARKVPQVVFMTPNMMNDGHNTTLEYATEWSHKFLEPLLADRAFDEPTLIALTYDEAETYEEPNHIVTLLLGSAVPPALRGTTDDTFYTHYSMLSTLQANWGLHNLGRYDVGANVFKFVAEKVGYAGNRDPENAKSVNNSASYPGALYDDPAKRLPIPPPNTRLIGAGGMPVLPAIIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V987</accession>
    <name>A0ABR3V987_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_2786</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="15">
        <location>
            <begin position="552"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="473"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="793"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="880"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="819"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1838325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="940" mass="101730" checksum="0D72BAD23C0CDC65" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9P4</accession>
    <name>A0ABR3V9P4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="192" mass="22105" checksum="9CC927D8ACAE4DC7" modified="2025-10-08" version="1">MPAYNSVFNTADPPPRLVGNFPLFPLRTKLRGPVYPLPFPDPPLPAHESPDPSSESYDILDEVLALFRANTFFRNFEIRGPADRLLVYGIWFISDCLTRIKPHASLREATKEVQNLALDLNFAIPGDPGWPLNQMYEPPRDRQDAEVLRQYMSQVRQELATRLLARVYDEGDDKPSKWWLSFTKRKFMGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9S5</accession>
    <name>A0ABR3V9S5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000212">
        <property type="protein sequence ID" value="KAL1838474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="789" mass="84625" checksum="47640B42D80F16D2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA35</accession>
    <name>A0ABR3VA35_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000216">
        <property type="protein sequence ID" value="KAL1838412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="378" mass="42526" checksum="A7BBF079DAEF9A13" modified="2025-10-08" version="1">MGQQLCCQASTPQRFSRVTLTIRDEAKLRADLEQWNAILDRDGRFRHIRRVVVLGTMDTSAPSEGVGTSVGSGWRDSDSESDTEDEEDAYKVSFNPAKPVLSPQYKQAQNEAWLPFVHFLSKLPALTDLVYACTNPIPACVLTELHERHPKSRLHVRTFSLRSLYQEWNDLHDVDPDEYALVTSPCLYSIHTKCLAYDSDDGRFSFNLEALRHMVAMGYAPNLRHLRISPAQPPAPDSRRAKLESLVVSTNRNDPSELRAWLARTDFSFLRRFEHYCGLSPACLEILTSLGASGKLNSLRYLGLDLSMEDDDDGNSHDLNDLAVQFFRSLPPLEKLTRRESAVSNATVPASRTCNGVYAAVMAVQKKSLFITYALLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAE4</accession>
    <name>A0ABR3VAE4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nitrate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_2782</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 17">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the nitrate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000220">
        <property type="protein sequence ID" value="KAL1838351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012137">
        <property type="entry name" value="Nitr_rd_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000233">
        <property type="entry name" value="Nitr_rd_NADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14 17" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="551"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="652"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1838351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="923" mass="101803" checksum="6CB68D34C5A7AB1A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAP1</accession>
    <name>A0ABR3VAP1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000190">
        <property type="protein sequence ID" value="KAL1838850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="623" mass="69706" checksum="40E2FF5E6FA17CB0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAS2</accession>
    <name>A0ABR3VAS2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000211">
        <property type="protein sequence ID" value="KAL1838486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="176"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="410" mass="43290" checksum="76DEC28FFD274BD1" modified="2025-10-08" version="1">MANMNSVIDDEIRQRHAEISSLNKHIYDNPELAYEEHKAHDAFVAALQSLGFNVTPHAYGLETAFSADVGSGGRLVVFNAEYDALPGIGHACGHNLIASASFAAFLGAAAALKASGRPGRLRLLGTPAEEGGGGKLKLIENGAYQGASGALMVHPGSARLLPPGVRGIASIRMLANVKMRAFFKGREAHAAIAPWDGVNALDAVCLSYNGISMLRQQIRPHERIHGVIRAGGNRPNVTPADCVLEYYVRSATRATAEALWQRVKNCMDGAALATGCSVSYEPLNSYADVRPSKAICKAYVEAMTEAGCEGKVALDGPGAAEVLPGSTDMGNVCYECPGFHGVFGIESPAGASNHTKGFTASAGTEDALARAVDCGRGMARVAWKLLEDDAFAEFVQKEWEEDMKLAAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAS5</accession>
    <name>A0ABR3VAS5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_2272</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="170"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1838735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="469" mass="51824" checksum="EEBBE4661D771192" modified="2025-10-08" version="1">MAIEELVRWLEQLVWLLWETACERPVYFLFTTILPLAALAAFCIFITLHLVAPKPRLPFPSEKTYITTNPDGSISSPRPLPCWYDRWRAEGFLAQEYPTIPKGFPLPSEPTIEPAEVEVSVVIPAYNEESRLTPALEEMVEYLDQQFGRPGTNGGTTTTTNNNNQFLHPERQERSAQKQPPSKKGKRATTPHRLVFRPDPSTSRPGSSHSTTTNQPPPSPTTPQPCSGYEILIIDDGSRDRTVEVALAFARKHGLHDVLRVVRLEKNRGKGGAVTHGLRHVRGRYAVFADADGASRFSDLGRLIEGCEDVVDGSNRGVAIGSRAHLVGSEAVVKRSAIRNFLMRSFHFVLTILTPPATSRIRDTQCGFKLFSRAALPHIVPYMHTEGWIFDIEMLMLAESAPATPVLASDGSVIGTSSGIRVAEVPVGWHEVAGSKVNLVQDSVRMAVGLAVLRASWMLGVYRRRLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAT4</accession>
    <name>A0ABR3VAT4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000184">
        <property type="protein sequence ID" value="KAL1838943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="170" mass="18431" checksum="72F88D6D79E1CD8B" modified="2025-10-08" version="1">MVGVLQVVSMAKAKVTTAPQMRSPDRPTPRNKKNRSYKGEVILSLDESATVDRYANPFVNDTKVNLVDRLSLDSLAGFAVVEGGRGSTSWKTGDGLGCGRCKEKIEGKKATGDGEWLQRWPKWTESRPPDNRVAGALRAGGVGRLQLETLTLVGRRGEGGKRGGEMGDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB44</accession>
    <name>A0ABR3VB44_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000185">
        <property type="protein sequence ID" value="KAL1838927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="438" mass="47286" checksum="B683E3C222991283" modified="2025-10-08" version="1">MKALGVRVEDLPWSSISTELLLAELSRRDDAQTRPACGSGQKGSYDTGIHVFALFLILALSTLACGFPLVSQRLTKGTKRQRTILFLCQHFGTGVLMATAFVHLLPTAFTSLTDPCLPHFFSQGYRPLAGLIAMISALVVVALESYLTTRGAASHAHSHAWDEDEDDSDDGANGHAAAGHTHAHAESSRRARRDRPSDIALDDLEATEGLVSGASPLPGATPMLSPNPDTRPRKSHESSRRSSVDDDDRESLDLERPKKHETGLPPLEHVPSPEEQRRMTLQCVLLEAGILFHSVFIGMALSVATGPTFVVFLIAISFHQSFEGLALGTRIAALHFPRSSPRPWLMVLAFGATTPIGQAIGLFVHRFYDPMSQTGLLMVGFMNAISAGLLLFAGLVQLLAEDFLSEKSYQTLRGRRRVKAYLAVVAGAALMAAVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBB3</accession>
    <name>A0ABR3VBB3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000174">
        <property type="protein sequence ID" value="KAL1839123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="885"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="943"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="973"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="973"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1284" mass="144624" checksum="2FB8D7D7717EFF7E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBZ4</accession>
    <name>A0ABR3VBZ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotically up-regulated 65 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000163">
        <property type="protein sequence ID" value="KAL1839330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1152"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1350"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="303"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1163"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1379"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1401" mass="157461" checksum="40976DA75F9E61E6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC74</accession>
    <name>A0ABR3VC74_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000159">
        <property type="protein sequence ID" value="KAL1839405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="177" mass="19269" checksum="E99082C7EAA8330F" modified="2025-10-08" version="1">MSASSDQVAAAARLILSDVGRRITAHWYCCGGSSSNNTNPRSPSATAIVLLRAAANAIHVGFGLYYRHFEGNWTQVLWPVVDQLVVAWAVSFVVEEEGERTVFGVKLTENFFDGFLYFWAFLHGLHLVLLAALVLSYAYFFGQTGWFFLTALGLAILPVAWVAARPGVDGDGGLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCC8</accession>
    <name>A0ABR3VCC8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000161">
        <property type="protein sequence ID" value="KAL1839362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="83" mass="8624" checksum="9FDA466FA409F33A" modified="2025-10-08" version="1">MTRGHEVTTLSTKYHPLFPPLTVAHSFHELVLPRAGLTMLGSVPGQMLTAGAKCSPGLAVGKWGQLRGGSDRAAVDLASAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDD3</accession>
    <name>A0ABR3VDD3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000143">
        <property type="protein sequence ID" value="KAL1839722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046617588" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="111"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="428" mass="45637" checksum="41D555E09070DB50" modified="2025-10-08" version="1">MVTLTNLVLTTAFAAAGLASVIPPKIGTTVLDNGHGTSSGRASLKQVRRPGYRFNGARDIYKTYLKYGVPVPDYLKKAVANIDALNAAAVSKREKGSAPAIPVDPRFDIAYVTPVTIGTPPQTLYLDFDTGSSDLWVFSSHTLASQVRGQMIYSPEKSTTAKLLAGHTWSIRYGDGSGSLGNVYTDNFTVGGVTVTSQAVQTAQQVSTSFTSESDIHGLVGLGFSTLNTVYPNGQLTFFDNAKSQLDSPVFTADLKWKKEGTYDFGFIDETKYTGEITYLPVQTDPGYWTFTSSGYAVGDGSFNQVSISGIADTATSLTYLPTAVVTSYWRQVEGAVNSQYYGGYVFPCSSKLPSFTFGVGSANITIPGSYINYAQITEGSPTCFGGLQSSSGLGINIWGDVALKAAFVVFNGGNPPTIGWARKPLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDG3</accession>
    <name>A0ABR3VDG3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000157">
        <property type="protein sequence ID" value="KAL1839441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17112" checksum="3C993F638D2559C0" modified="2025-10-08" version="1">MPGGVSVRDVDAHKFINAYAAFLKRQGKLPVPGWVDTVKTGHGREMPPQDIDWFYVRAAAVARHVYLRKTVGVGRLRKVHGNSKNRGTRPSKHVDASGSVDRKIMQALEKIQVLEQDEEKGGRRITQQGQRDLDRIAQTVAEAEAGEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDX0</accession>
    <name>A0ABR3VDX0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="291"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="588" mass="64261" checksum="1F47A5714D48288D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE80</accession>
    <name>A0ABR3VE80_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045398928" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="43"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="180" mass="20202" checksum="217DF88DB0CB218E" modified="2025-10-08" version="1">MRFSTLLFALAASVADARNIYRPNSDQSLVKRTDLDVPGQNPLQFCEADREKDIITIEEVILTPNPPEAGQTLRIEATGTVKEDILDGAYVNLDVKYGYIRLIRTTADLCKEIQNVDLHCPIEKGKISIIKEIDLPKEIPPGKYTVEADVYSKDDEHITCLTAVVFFNRKPLGGMFDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEA7</accession>
    <name>A0ABR3VEA7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="367" mass="41390" checksum="5E20D3064F86606E" modified="2025-10-08" version="1">MPQDPHLYGQPRPKRQKKEIAISGSLAFASELSSLLTEPTSAPSAAPASSSASTAITSGRTRPSKLKTDDLSNTKIRRSKDPSASVARDQQQQQQQPSKLSLKSPLGTEESKAERDFIRRKMESKARLYAAMQRGDYIGREFGLVDFDRKWAESQEQKKKNGKINPDDAPASDSDSDSSSSDSETDASLDTTLHEYTDEFGRVRLLTRAQIARLERRAASAAELARMSARPKAPEELIRGDAVQAEAFSARDGEEAMEALARKRDRSPTPPDPEHYRADREIRTKGVGFYKFSVEEEKRMEEMRALEEERRRTEEVRKEREEAAKRRKEEIEKRRKEILEKRTRKMADSFLEGLGRDLVGTGEEGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEF0</accession>
    <name>A0ABR3VEF0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_958</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="546" mass="57719" checksum="760009274274EB67" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEK3</accession>
    <name>A0ABR3VEK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000145">
        <property type="protein sequence ID" value="KAL1839688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="54202" checksum="BA33B4886CE81349" modified="2025-10-08" version="1">MDPSGATGAPPQVQPRPRKRPRTTRAAAEAANAATSSSLTPVAQAQGWGAATVTNGHNQAVRAPVDTVPNQQPQHQGPPGFPSQQLDRSHQVGEPDALMTTYTTAPQHSQYPDPQPTLAPAPQPDTSGLTSLSALAGDPQHHQHAQHGHQHHQAQQPGPSQQQQQAQSHHQQQQQQQQQQQAQRGGGKSDRVLYQAAYGAPHPPSNSSPTSVNNPTTTAAGYNLPAWTVPDAGPSATQQSPAQPTSSMPPPPSPAMASTTAGLAPPPEGIYRTFDDLLASVQRTAKEQGYSIVKLRASNYREGKPTRYDLVCDRGGVKYNSTAKKRNPSTRKVDCPWRAKAVCEVNLGHQWRFAVQEARHNHEARVAAAAPGQENTPVAQSLRSLTNKVDRIAHDMNQNFSRLEAVFNARFDNIEKRLEALENGGRPNPATMALGGSGVPQMGGPNMPTANMGGSGLGSGSLANGTMQPLVDSRLSGVESRLSQMESRALDGISMMDDDGRGLSMMVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEY7</accession>
    <name>A0ABR3VEY7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000115">
        <property type="protein sequence ID" value="KAL1840380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="301" mass="32306" checksum="8DB382C4BC63A859" modified="2025-10-08" version="1">MAPSTITLTIPEITTYHKRPYPRISPNQPSLTQASRTVLIVGGSAGIGLAIARAFIHASAATVIVTGRRPSALAEAVARLKAEVPAHGSTAVRGIVSDMADPEASAKLWDGLRNEGVVVGVLVLNAMATGEAKPLVEAGVESVWRAFETNVRGLLDYTERFARQEGEGKKYLINLSTSGIHNYNAETAANPAYSLTKNAGTLAVQLVAKDTDPTALQIISFHPGGVLSESARNAGYDESTMDWDHEDLPGQFAVWLATEEAQFLHGRFVPVWWDVDELSTGPARERIEGDEHFLRIGVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF36</accession>
    <name>A0ABR3VF36_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="201"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="649" mass="70300" checksum="BDC19245AE080146" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF48</accession>
    <name>A0ABR3VF48_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="313" mass="34061" checksum="AB702A4D5CC0A720" modified="2025-10-08" version="1">MASSTTPSPVLKQPVRIACVQLASGSDKAANLARAAEKVREAAAGGAKIVVLPECFNSPYGCDYFPRYAETLLPSPPSEEDSPSFHALAAMARDNGVYLIGGSIPERETTPSSQEGEELQTRYYNTSLTFSPSGTLLATHRKVHLFDIDIPGGITFRESDVLSPGNKLTVVDLPEYGLVGIAICYDVRFPELATIAARKGCFALVYPGAFNLTTGPLHWELLGRARALDNQCYVALCSPARDMRGVYHAWGHSLVVDPMAKVMVQAGEKEEIVFADLDDQRIESARTGIPLRHQWRFDVYPDVSQGKVNIGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF49</accession>
    <name>A0ABR3VF49_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000113">
        <property type="protein sequence ID" value="KAL1840440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="974"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1140" mass="122873" checksum="538AB1637BB83410" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFH5</accession>
    <name>A0ABR3VFH5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000107">
        <property type="protein sequence ID" value="KAL1840575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="3">
        <location>
            <begin position="1361"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1580"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1730"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1799"/>
            <end position="1810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1839" mass="202079" checksum="D5A9304ECD2570CE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFR8</accession>
    <name>A0ABR3VFR8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="309" mass="33537" checksum="39B1A8A4C93DCBDC" modified="2025-10-08" version="1">MATTSPHAPWRTLFLTHLRSLGPSPTFTLANLHPVTQADGAPSPALPCLPRARTCVFRGMWADPLPDRSSNGGYQNPAPRNPTGVYTSDLLVFTTDARSEKAGDIFDSAAAGDVEASGGTTGGGGPVEAVFWIDRDPATGTAIKTQWRVRGHAWVLGPGAEIDRAAGEVEEKGDDGARRVREALLRRMKKVGEPGQEESWSFEREVTAHFGNLSPLMRGSFRGPPPGAPVAYHTAKGEVVGQSVEDVNDAAARANFRVVVIVPDEIDQVDLSDETRPRRWLYVYRGESRESKLPGGEIFGEWEQVEVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFS2</accession>
    <name>A0ABR3VFS2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000102">
        <property type="protein sequence ID" value="KAL1840705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42926" checksum="658CC45A6A31E9E5" modified="2025-10-08" version="1">MEPTITNPTDDEPRTLKAVWADAEAKRLALESTSFPPNSPDYADTVSSVVRLYNESISLISALSLFSPNESAEDLSTSNLPFLLANFHLAEATQRLPGPTPPERKRILAASRDAYERFLHLLDSYSLLSDDHKKLLERYTEAPESFSTVPASADPATRRATKIANLQAEKQLRARLEFLRRRPEYGDPDADGTGAAGVGDEDAVRETHLTHLRYSTHMTFQALEGLNRELEVLAMAPPTPPPPGPTTGPTTTDSRDRRHATTNQPQDYSHRLDTPLTQTSTINKGGPLLSRTGKPLQPFTLLNNRQELARGVFRPGHNLPTMTIDEYLEEEKRRGGIIEGGGEASWHRPEPDEDDIEKADEETMKARAWDEFVEANPKGSGNTLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFW9</accession>
    <name>A0ABR3VFW9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_151</name>
        <name evidence="3" type="ORF">VTJ49DRAFT_4446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000346">
        <property type="protein sequence ID" value="KAL1836951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000100">
        <property type="protein sequence ID" value="KAL1840759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="491" mass="54678" checksum="61D7078C737E002F" modified="2025-10-08" version="1">MFSMLPDLTPRDCHSLWYTSSRNPHLPLSLTLAISQSDPAPTILDAHASTNPTTTTTGTTPAANPTQNTPITAPTPAAANVPNPRHHAHHAALAAQIIDRSLLGRLHAEEQLLERRRAAVSNLGSTWLKPPGVSKTLFQMREERREAEEHAEAMRREMMVQELAAAEEAAAAAAAAAEGVEGEIAGEVGVEGEMMMEDDGMGMEGDLDAEIPDGDVSAGFGFGSDEEEDEEEDEEEDEDEEQGSTATHEQDEDEDEEEEEEEEDELDRIRRREEAALSDEELARRRELRADYERQRALEARMAEVEERNAAQLRRLERQNRALRFDDDDYGDLSEDERSGLLEEEDLVRRGQQQQQQQQPASTQQTQTQTQTPSQQTRRGPQIPPASAEADDDDMDMDADLDDDIPEGESGVGYEHTDSGASVDDDDDDDTHDLSYARSSRVLHHHHRQHHGRSSMRRSEGPRSSLDISGLLSGNESSIMETSPHFRRGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG46</accession>
    <name>A0ABR3VG46_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="71981" checksum="AFB1E46D969D5AEC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG85</accession>
    <name>A0ABR3VG85_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="284"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="917"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1021" mass="115853" checksum="4C74809011EA0289" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG94</accession>
    <name>A0ABR3VG94_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000100">
        <property type="protein sequence ID" value="KAL1840756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9218" checksum="8D49F585880429D2" modified="2025-10-08" version="1">MNGATPRFWATPLRYCRWAARERPAYFWSVVIGALGPVTLVTVPPLRRAVGDYDAPPIPLTYPVPTGPRKQLTGYDDDTERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGC8</accession>
    <name>A0ABR3VGC8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Antiviral helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7659</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="594"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="874"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="793"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="814"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1561" mass="172420" checksum="7E81FF8A62530F5D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGN6</accession>
    <name>A0ABR3VGN6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="153" mass="16704" checksum="A439300D4C0ABA32" modified="2025-10-08" version="1">MGHDCWGLDFLRGAVDGEGDTAFGVWPCVRSLARGRWLVRRASGPCRTVEWATGPRCRRLERSLSRTCLPALFPPSPVSLVGWTGDKDRLTRPLSKTLATVGEIALRLGHLDLTAKGNEGTVPKTAASLARFREAETFAEISKAPWVFARPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHB9</accession>
    <name>A0ABR3VHB9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000102">
        <property type="protein sequence ID" value="KAL1840708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="888" mass="95451" checksum="CE0D0E39C01E0392" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHC0</accession>
    <name>A0ABR3VHC0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="346" mass="37653" checksum="85ECCA6FD149130F" modified="2025-10-08" version="1">MASVEDYGPRLNATIWPLTGGAALFLALRIFCKVLRHRPVAWDDYVLVASWCALATSCALLTVITTIGYGRHNQDIPAENFATVLLVSYVAGFFSMLAACWSKISFAITLLRIATTSHVLTRLLWTIIIVVNIVFAGNATAHFAQCWPPPRLWNPEVEGKCWPRIAMIRLNIAVAAFSGSVDILLALLPWLIVWNAAISRREKLSALFASSMGVFAGITSFLKIRTVDAAIGSKDMVDSVNLLIFGTAESAVTIVAVSIPILRALFSLAGIKDIEFSPVLPPLPLSPPPTQQKPPLASYQLPMPDVSSFSIEEGLGAPGVGKDRRSLSNASFEFDVEKHMEAMRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHP5</accession>
    <name>A0ABR3VHP5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="201" mass="23082" checksum="FC37474045FCC098" modified="2025-10-08" version="1">MKVFSNTETFNYSWEEVSTANWRKYCPWNQKSTHVVAVDTLSRTVDPETGILRTERLITCRQSAPDWLKKMIGGNIDDSHVFETSYVDPRSKTVTMVSSNLTWNNLISVQETVVYRPANEHQTRFEQTAQITALCGGWQRIKSSIEDTLVKRFHENAIKGKEGFEAVLAMSRRVFAEEREREKMMMLQSQAANIRLAAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHP6</accession>
    <name>A0ABR3VHP6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="163" mass="17893" checksum="81B679D7F44F5147" modified="2025-10-08" version="1">MPIHFLHQSVSFDELTALYAVSDVCLVSSTRDGMNLVSYEYIATQRERHGVMILSEFTGAAQSLNGSLMVNPWNTEELANAIHDAVTMSPEQREANYRKLERYVFKYTSAWWGQSFVTELTRISDAAAEDAAKAKLLKSAAPAGGEDAAAVEGKEEEKAAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHS2</accession>
    <name>A0ABR3VHS2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="305"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="862" mass="95316" checksum="306942B5B309BB6F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI71</accession>
    <name>A0ABR3VI71_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000077">
        <property type="protein sequence ID" value="KAL1841378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="89" mass="10291" checksum="6637C9F31475B903" modified="2025-10-08" version="1">MAFFKTLIDHEVTVELKNDIQIRGVLKSVDQYLNIKLDNIQVVEEIKYPHMVTSLPLLCPFPPLPLPRSMPFLSFEADQRARVGKNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIA7</accession>
    <name>A0ABR3VIA7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="100654" checksum="2CC6FA8D9C24C01A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIL1</accession>
    <name>A0ABR3VIL1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="220" mass="24829" checksum="4A90FDDF35D60487" modified="2025-10-08" version="1">MDEIMPDPYPYIPARRIWVTNLILRIFEIICNFTLLGLGDKLTSGRPQGTNVFIYLLPVSVPSLPWALLDAYALLSRQLRRERPPVVPMVLDLLIWMVIIPVLTLMYRDFIGELPLIPQRERLRMAILAIVGLLGATGRLFHFVNFVLACVEYCSRCNRKRRTGVEGTINALPPQGCDAESAPGVDCNQQHRSAPHRSYEPHIDAPQSPPQTYQQGSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIM1</accession>
    <name>A0ABR3VIM1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial F1F0 ATP synthase subunit Atp18</fullName>
        </recommendedName>
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    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6631" checksum="014EAD6E3B7736CD" modified="2025-10-08" version="1">MSWFGVTPLKKFPTPVLRPMAPFLAAALVIGYGVNSAQNAMMNTDEFKNDPRNPNARAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIS5</accession>
    <name>A0ABR3VIS5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="347" mass="40086" checksum="F5F4EA0EA512C41B" modified="2025-10-08" version="1">MKPRQEHPQKEDDDLLPRQDTTQNLELRSKRTERQRRKREKKAGSLTRAASDTQLLLGLPVELLTAILELLRPSDLLALARTSRVLHGFIFANEADLARRVIRLRYPILEQCFLRPVLMRDIDAAIQPLLQGSYRADLAGIQQWPFARISIPSPDYALHCTCLTCLGRWNALCVVVDFAHWQDVLDNGEPIPDIAPGTSPKWNQDLLARTRRIVLAALTSPLRYARLLEVHLESTRRSVLRHSRNKTDRRPHYRMTTDMAETDAFLGQKGPPTVEFPYSREVYYLLEAFLPTRSWLTSQQRWGYIQRPDEWHQLDLDLLVRMVSLNRASQDAHVDQDSAATEGNRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIW5</accession>
    <name>A0ABR3VIW5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020241">
        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="231" mass="24424" checksum="963E4434F960C6C3" modified="2025-10-08" version="1">MASSSSTGNDPREVKPLPNRPETKLPPIPKGARIHKRPLPIPATTTRLRRNAPSSSSLPGGLSTAADIDGYLPPPRASHTIVIKVSSTATFMSLVRRVRKALDKAPRRQATRGLPLAARMAALKVARPASTVPAAGGGGGEGGGTGVGQIQDALDDVVLVATGRAIARAVDVAGFFTREKDLAVLVRTRTVRAVDDVLAAEEEEEEECGDFEEQVRVRNVSCVEVGIRWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ30</accession>
    <name>A0ABR3VJ30_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_6682</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000066">
        <property type="protein sequence ID" value="KAL1841708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="13">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="153"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="723"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1002"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1170"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1889"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1058"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1197"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1934"/>
            <end position="1950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1841708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1950" mass="216235" checksum="F392C1C9E61A9BEB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKA3</accession>
    <name>A0ABR3VKA3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="179" mass="18807" checksum="8A3E6D10E8E0A5D7" modified="2025-10-08" version="1">MDFQTQNRACFTCGDTTHQARDCPNKAAAKCYNCGNEGHMSRECPDGPKDTKICYRCSQPGHILRDCPQGPVGGGQAGVECYKCGELGHIARNCPKGGFGGQGFGGGYGGGYGGPGPKTCYSCGGIGHLSRDCVNGSKCYNCGETGHMSRDCTKESAGGEKICYKCQQPGHIQSQCPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKG4</accession>
    <name>A0ABR3VKG4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="181"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="417" mass="46335" checksum="CE8CD89CAC1DB1F4" modified="2025-10-08" version="1">MTIFSLRKKLSNLVLRNRQTPDDPPSDDDDTTTTRTFFPRNPHALDTLPVLPPRRPLTSGQHTNPQLSSPFFRLPAELRLLIYRLILSPTDPNSNSSSFTKPGSEIHLDLRYTAALTAPRTPHSTRGASLSPEGRQWAWRASRCHRHPDALPISDRCVWGGPPPTACAWYVERGVAPECFIGPEVLGLLRSCRRAYREALPVLYGENTFHVGSGAVVLFAERLLSPAGRACVTRLVLTVSEETVWMYAEEHLGVKPGLGVYELVVGKVPAAFPGLQRLMVVAYGPLFRREFVQLGGHDLHVPVVQGDEDAKRGVVRDALFAAMNAAVAGFARPLVHAMLVVRLDAFDRLMLDEMPGAAGAEVREGQWRQFWRPLGEDRSDGARESRGYWVRGVDEERAASIWNPIPGWMPPEVALNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL04</accession>
    <name>A0ABR3VL04_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 ubiquitin-like" evidence="2">
        <location>
            <begin position="586"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 ubiquitin-like" evidence="2">
        <location>
            <begin position="648"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 C-terminal" evidence="3">
        <location>
            <begin position="799"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1016" mass="108122" checksum="09631BEE055BD1E3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL26</accession>
    <name>A0ABR3VL26_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_4769</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="739"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1842589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="781" mass="89275" checksum="4B9B2D9B67CFFBC9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL41</accession>
    <name>A0ABR3VL41_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_6798</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF384">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046069241" description="chitinase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="95"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1841621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="491" mass="53128" checksum="8B72C4805EC1A644" modified="2025-10-08" version="1">MVVASSLAYLAAPLALLPGAWAAPKSVSLRGGEIAQVQCEGTTATVTQTVYLPAQSPAATSSQRSSGTSPSPVPSPQPPQTVTTPSGNNKGFSGYRNALYFTNWGIYGANMQPQQIPAEQVTHILYAFADIGPDGEVKSSDSWSDTDKHYPGDSWNDVGLNAYGCVKQLYILKKKHRHMKTLLSIGGWTYSPKFAPVAATQAGRQRFCDTAVTLLKDWGMDGLDIDWEYPSNAQQAQDYISLLQTCRSALDTYARQHAPGHHFLLTIAAPAGPQNYNHLNLTAMDPLLDAWHIMAYDYAGSWDTTSGHQANLFPSQRNPESTKFSTERAVHDYVARGVPRRKIVLGMPLYGRQFENTAGPGHAYNGIGSEGSLQGQPGIWLYKDLPRPGATEYFDEEVGAAYSFSNSSSGNSGGGTMVSYDTLTSVKRKVEYLLEKGLGGAVFWEAAGDKTGDQSLVAAVRKGMGQLEQSQNWLSYPASRYENIKAGMPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLE8</accession>
    <name>A0ABR3VLE8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="611" mass="64948" checksum="24BA5A929416A4A8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLV1</accession>
    <name>A0ABR3VLV1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4374</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="11">
        <location>
            <begin position="1510"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1794" mass="196584" checksum="924D57821D614A9C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM66</accession>
    <name>A0ABR3VM66_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
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            <end position="517"/>
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            <end position="334"/>
        </location>
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            <end position="466"/>
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            <end position="436"/>
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        </location>
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            <end position="1081"/>
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        <location>
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            <end position="1141"/>
        </location>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAL1842899.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="1154" mass="124290" checksum="57C50FF8D2D20E51" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">VTJ49DRAFT_3704</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
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        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
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    </dbReference>
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        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VML9</accession>
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        <recommendedName>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="220"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="914"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="898"/>
        </location>
    </feature>
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        <location>
            <begin position="884"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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                <person name="Mondo S."/>
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                <person name="Moisan M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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        </location>
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        <location>
            <begin position="297"/>
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    </feature>
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        <location>
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        <location>
            <begin position="23"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="495"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="55828" checksum="E2EA3DE75C489F91" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNJ1</accession>
    <name>A0ABR3VNJ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannan endo-1,4-beta-mannosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04086">
        <property type="entry name" value="CBM35_mannanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CBM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF4">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046381988" description="Mannan endo-1,4-beta-mannosidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="8">
        <location>
            <begin position="52"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="9">
        <location>
            <begin position="191"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54466" checksum="8AB85C7CED5EECD6" modified="2025-10-08" version="1">MAKTLQYLVWGLAALAARTAAAPYCPASQAPSTTSQTPTNTPSPSDTPSGPRTFEAEDAILSGTRVESTLSGYTGTGYVGGFDEASDKITFKVDSATTRLYDLSIRVAAIYGEKRTTVVLNNGPASEVYFPAGDSFVDISAGQVLLNQGDNTIDIVNNWGWYLIDSITLTPSAPRPAHQINPSPVNPAADANARALYNYLRSIYGKKILSGQQELSWADWIAQQTGKTPALVSVDLMDYSPSRVERGTRGTAVEEAIQHHQRGGIVSVLWHWNAPAGLYDTEERRWWSGFYTDATDFDVERALADTTNANYTLLIRDIDAIAVQLRRLEDAGVPVLFRPLHEAEGGWFWWGAKGPEPAKKLWGILYDRLVNYHGINNLLWVWNSILPEWYPGDETVDILSADVYAEGNGPMSTQYNQLIELGKDKKMIAATEVGAAPLPDLLQAYETHWLWFAVWGDTFINNAQWNSIETLRTIYTSDYVLTLDEIQGWRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPD2</accession>
    <name>A0ABR3VPD2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="293" mass="30490" checksum="D4AA1CDA51479D28" modified="2025-10-08" version="1">MSDRLAQIARQLNYPRGLLAGQVAIITGAGQGIGAECARLFANEGARVVVSDIDGPKAEEVAARIRASGGEALAVAGDLLRDEAITDLVKKAAEFGGGKIHILVNNAGFTWDAVIHKTQMTDKQWQTMLHLHVTAPFKLIQALAPYFRVKDGEPRNIVNISSTSGLHGNAGQANYAAAKAAVVGLTKTVAKEWGPAFGVRANTVAFGRIATRLTADKEDGGFIEVDGQKVALGIPAKQKKGDAAAAAAEQYADIPLRRPGTATEAASAVLAIASPLSSYISGQTISVTGGRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPG5</accession>
    <name>A0ABR3VPG5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="3">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIF6</name>
        <name evidence="5" type="ORF">VTJ49DRAFT_367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <text evidence="3">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylation at Ser-697 and Ser-698 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="3">
        <location>
            <position position="697"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="3">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="769" mass="84860" checksum="284A12854F3CFE50" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPH7</accession>
    <name>A0ABR3VPH7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease</fullName>
            <ecNumber evidence="8">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7519</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="10">
        <location>
            <begin position="100"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="9">
        <location>
            <begin position="101"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="347" mass="37781" checksum="B93A9FB84B4141FE" modified="2025-10-08" version="1">MSKATLAIIAAASAGAGAAATAAVFSLRSDKHDLAATTLNAPLPPPSTSAPITVPVPASQVFTPPPPAAAPARPSGPIAPVDPSGLFQYGFPGPVSDLAARPSLISSYDRRTRNPHWVVEHITPASLAIRDGDRKNSAFLEDPIIPEKFRARLADYFRSGYDRGHQVPAADCKWSQQAMDDTFYLTNMCPQVGDGFNRDYWAHFEDFCRRLTQKYPSVRVVTGPLYLPKRDPADGKWKVTYEVIGNPPSVAVPTHFYKVIYAEEEAPGKQENGKVALGAFVLPNAVIPNSKPLSDFEVPLEAVERASGLEFASKLPVQKRKRLCAETNCSIIVKEYAERQKAFAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPK2</accession>
    <name>A0ABR3VPK2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="457" mass="50285" checksum="D5830211B2F4D909" modified="2025-10-08" version="1">MSAPHQTDVTVLDGTAYEGGGGLIRYAIAFASILNRPIRIHSIRAHRLEPGLRSEHTVAVGTMAWLTSAALMGNQTASLDLMFSPYVHLDARNEPLENKLDIALEGSASIFLIAMLPYLLFSRLSSKVHDIPPGPDEFELTIRAGTLCVKAPSIFYLRQVFLPTMALVGIGGNHLSIGEDHEQGWHTQMQSLPGKMTARIRALLRPLPAFTLQHRGRVQTIRATAHAPQQDLDKFKSTLEAEMADAISQNGGVSVAIDMFPSLLDHHYHLLLVAEATAPPAFLGFEDMFPQSDVFPPTTLNGDTDGIIRHLVRACIRGLWEELRRGNPVDENMEDMLPLYQGLAAGFSSAMTPGNHRPVPVPEFNMETPALRDDCYKLDRSSLHRETSWWTVHQFTGLQPVTVQVEGSDQVGCHGIGFGAEDEVGNSTASQDRLEKRKAVTTYRSWLTPLQCRGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPP0</accession>
    <name>A0ABR3VPP0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
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                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Henrissat B."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="559"/>
        </location>
    </feature>
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        <location>
            <begin position="481"/>
            <end position="559"/>
        </location>
    </feature>
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            <begin position="492"/>
            <end position="501"/>
        </location>
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            <begin position="513"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="546"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1843849.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="60594" checksum="505265A66B16124F" modified="2025-10-08" version="1"> </sequence>
</entry>
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    </organism>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
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        <subcellularLocation>
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            <orientation evidence="2">Cytoplasmic side</orientation>
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        <subcellularLocation>
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            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1843860.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="DUF2205"/>
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    </dbReference>
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        <location>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16461" checksum="48B22CFCA5244E62" modified="2025-10-08" version="1">MMGDPSSHTSSNQQWSESSGSPVDGASTSAEASLAVRFGPPSRENSGVSAAPANSPNPSPLEQQIDSYNQASASPRRTSEDLQQLCNQTREEVHRHARALQESLATLFNQIEAVKEEHDKLYNHNKFLQQYIGDLMSTSKITASSSSRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR84</accession>
    <name>A0ABR3VR84_HUMIN</name>
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        <recommendedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">VTJ49DRAFT_2369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1844312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="67767" checksum="FB3A4B73C1F8413E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRI6</accession>
    <name>A0ABR3VRI6_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="498" mass="56049" checksum="B0F4F7E69B45E5D1" modified="2025-10-08" version="1">MTSLVPRAPYTDEELRKLYPPGLELRQVQVLMRHGERTPVSARFQNAGLKPWWPYCSTARQMRAAVMGPRDPSLGPATDTLEWKRRLESIGANDEPILAKGPQDDPDAICDHGSLTDHGRRSTYQLGQRLRHLYVDRLRFLPPTLTSTDADTSLYLRATPVPRALESLHQAFAALYPPSAREPGPDGRFPTPTILSRTPDDETLYPNDGNCRRFAAMARAFAQRAAERWNNSPEMDLLNRRLGKWMPPGQRIAVDSRPRLSGIMDTINASLAHGPETRLPKEFYDPETRAVMERINVDEWFAGFKESSEFRTLGIGALMGDVVGRMVERVEQEQEKGIRFGLSGCHDTTLAGVLASMGAFETDRWPPFTSHVAIELFREAKNPPPQVEPAKRSWWSSLFGSSPAPRPIGRKPTSELSEAEKSKLHGYYVRMRYNDEPVTVPACRLPGNHLEGDPSFCSLAAFKAVVDKFTPTNWKQQCRMNRDKPPLPEGEPELAGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRR7</accession>
    <name>A0ABR3VRR7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxyisobutyrate dehydrogenase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_35</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="102605" checksum="E53466F3D6B037C0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRW0</accession>
    <name>A0ABR3VRW0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DOA4-independent degradation protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_71</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25579" checksum="5F2100AAE329B6BD" modified="2025-10-08" version="1">MNILEWAFGKRITPAERLRKNQRLLDKAIRELDQQRVKLEKQEKTLIAQIRQSAQKGQMGACKVQAKDLVRTRRYIEKFYSMRSQLQKVSLRLQTYRTNEQMMQAMKGATMALGSMNRTMNLPSLQRIAMEFERENDIMEQRQEMMDDAIDDAMDVGLEEEGDEVVEQVLEEIGVDLSQALGETPSGLQSMALPETRIAQAIGGGGGGGTDPGDDDLQARLDSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRW8</accession>
    <name>A0ABR3VRW8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_92</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="90"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="380"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1844413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="606" mass="66006" checksum="BA096BB8041EEDA7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1M7</accession>
    <name>A0ABR3V1M7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000584">
        <property type="protein sequence ID" value="KAL1835627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="251"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="251"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1835627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="841" mass="90716" checksum="F9FB2D27763329F5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1Y2</accession>
    <name>A0ABR3V1Y2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000552">
        <property type="protein sequence ID" value="KAL1835731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF6">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="85"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="332" mass="36172" checksum="A6E480FBBD889056" modified="2025-10-08" version="1">MSTSPHPTSILLLGSGELGTAILHSLTAHPSYNPAVTTKLSILRRPESLASGTQSSLPTPLGRGGRTVTITYEAADLAHDPIPTLAALFRTYDVVIHAGGFTAPRGTLLRVAEAAVQAGVKRFFPWQFGADYEAIAAAGGGGGVEHSGHRELFGEMLAVRELLRRQEWTKWTIVSTGLFMSFLFLRGFGVVDLEGRKVRALGGWDTRVTVTEVEGIGRMVAEMVFNPGEEMAGRSGVVYVAGDTVSYRDVADIVEEVYGGGFEREVLDMERLKKRIEEEPGDVMPKYQHVFGAGVGVSWEKEKTANYQRGIKLMSLREYVEQNKEALAEANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1Y8</accession>
    <name>A0ABR3V1Y8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000536">
        <property type="protein sequence ID" value="KAL1835790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="163" mass="17711" checksum="38BAA135AE4E1999" modified="2025-10-08" version="1">MPFPKKKRQIESEAEEEPQVTKKSKSKASQSAKGTLTQGKDAEGNPYWEIGKNRRIGFSEFKGSTLVNIREFYTAPNGELKPGKKGISLTLEQYKALLKVLPELNASLQAEGHDVGSLPSGPGGTDEAASSKATKANKPKRSNIDATSEEDEGDQEEEEEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V272</accession>
    <name>A0ABR3V272_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000533">
        <property type="protein sequence ID" value="KAL1835809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF57">
        <property type="entry name" value="PAAI THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="212" mass="23366" checksum="8826301D1FCE1FB9" modified="2025-10-08" version="1">MAVGRIQLCRLFRHSLRVLDAKKGAVTMELEIQPYHTNRLQILHGGTIASLVDLGGSLAVASRGYYATGVSTDLNVDLRPVSYMSSGGKVGERLKIAASCDKLGKTLAFTRVVFFDETDRVVARGSHTKSVSPPLLSTQLNAMCLKTDAKFHLSRFIAHAIEGNEPFVVPEEAQAAYEKAVAERAARRQAFGAWRARETEGSEEEESWRDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V276</accession>
    <name>A0ABR3V276_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000527">
        <property type="protein sequence ID" value="KAL1835837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056687">
        <property type="entry name" value="DUF7785"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057199">
        <property type="entry name" value="DUF7877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25009">
        <property type="entry name" value="DUF7785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25289">
        <property type="entry name" value="DUF7877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7877" evidence="4">
        <location>
            <begin position="67"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7785" evidence="3">
        <location>
            <begin position="453"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="907"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="943"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="974" mass="104797" checksum="6D942FEB2CB892E4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2U9</accession>
    <name>A0ABR3V2U9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000535">
        <property type="protein sequence ID" value="KAL1835796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="644"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="668" mass="72255" checksum="425F9A8F17F779F0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3N7</accession>
    <name>A0ABR3V3N7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000421">
        <property type="protein sequence ID" value="KAL1836370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="3">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="236" mass="26802" checksum="0D4F4B234640AF51" modified="2025-10-08" version="1">MASSAIHTSQLGGHAFSHRTSEDLEAEYDRLRNLARAEGDKMASCFERSREAYQRGDGALAKQLSDEGKRHKKKQEEYNKQASDFIFRENNHPDRVPEDAIDLHGQFVREAEAILEARIRYDREAGQSHLHVIVGKGNHSAGGVQKLKPCVERLCRDLGLDYATEDNEGRIYVDLRGRKVDSPPPMSRPSRDDGDGEHRPQRPQRPHRPHHQRPPPPKEEEDEGILACLKVCCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V410</accession>
    <name>A0ABR3V410_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000403">
        <property type="protein sequence ID" value="KAL1836497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="614" mass="69524" checksum="118B6EE73D9501B5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4E4</accession>
    <name>A0ABR3V4E4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000409">
        <property type="protein sequence ID" value="KAL1836447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="258"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="393"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="637" mass="70837" checksum="689218BF57B0FF44" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4F0</accession>
    <name>A0ABR3V4F0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000389">
        <property type="protein sequence ID" value="KAL1836615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="963"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1151"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1336" mass="148215" checksum="D0CAF2363F080E3F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4J9</accession>
    <name>A0ABR3V4J9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000376">
        <property type="protein sequence ID" value="KAL1836707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="78"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="544"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="615" mass="69615" checksum="3B5388ADAB097B04" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Z4</accession>
    <name>A0ABR3V4Z4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP-binding protein rho2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000399">
        <property type="protein sequence ID" value="KAL1836531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22287" checksum="9078C2FC0E74C480" modified="2025-10-08" version="1">MADDRGSQNVIRRKLVIIGDGACGKTSLLSVFTLGYFPTTYIPTVFENYVTDCRVDGKSVQLALWDTAGQEDYERLRPLAYSKAHVILIGFSVDTPDSLDNVKHKWVVEAQERCPDVPIILVGLKKDLRDDPVAIEEMRRRSQRFVSPADGEHVAKEIGARRYLECSSLSGEGVDDVFEAATRASLLMFEKSEGAGCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5D2</accession>
    <name>A0ABR3V5D2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000344">
        <property type="protein sequence ID" value="KAL1836967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF13">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045554988" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="173"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="400" mass="43276" checksum="B256136FE3303C72" modified="2025-10-08" version="1">MRSATLLALAAAGLVGQSVASPHHYHRNKRGYTTEIVTVTEWVTVTVYEGDDPQDRTTFTSFSTSESTSSSTSLDQPDVEPSPETANPPPPPPPESTTFTTIVAAAAPTPEQSSPAEVKDTPPPPPPPPPPTTSEDVPPPVPTVEEGNGDDGNNPTVPNPGPVNPGAGKSKRGLSYNDPGVLRHFLNAGNKISWTYNWGQYDDSGVDLEFCPMLWGLKLDFAERWPANAQKAIDAGSRCLLSFNEPDLGEQANMSPQLAAQKHIELMNPFQGKARIGSPAITNGGGNMGIAWMKQWFEACGGRCAVDFVVIHIYGVNTDTFLQHVRNVYDAFKLPIWITEFGFDGSDEEVNSQLATVIDAMENNPEFSFVERFAYFYAADGRMVRGNSLSVYGNTYAYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Q1</accession>
    <name>A0ABR3V5Q1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000332">
        <property type="protein sequence ID" value="KAL1837084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="363" mass="40662" checksum="5F61DB06F17144E5" modified="2025-10-08" version="1">MSGNSPPHPVPDPNAYYGDPVIPLAVVCIALTTLFVGLRLWSRGVILRALGLEDVFLVLAWLFGIGVLLAQIINIQYGGLGRQYAVFDSETLVRNLKKISFAITICYFFALVLVKISVLCLYVRVLTYPYVRLAAKIMLGVVGISHAWIIATMLTSCVPIEALWDLEKKKTAYCHSGDVWFSHSGINITTDFLISILPLTVLHKLHIPRRQKIALYLVFFLGFRYAALFQSAMSNLLTSPSVCIISLLRCLQFVRLGFIDVEHDTTPDLVIISIWTMLEVSIAIIVACIPTIKPVVSRFFPRFLASYPNRSDDDTEPWSGTLDQGRRRRYRQCGDDTIDMHLETIKASDHDSTEHGSRSGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V657</accession>
    <name>A0ABR3V657_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2884</name>
        <name evidence="7" type="ORF">VTJ49DRAFT_4336</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000335">
        <property type="protein sequence ID" value="KAL1837047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="362" mass="38816" checksum="643069DB6AD0AAC0" modified="2025-10-08" version="1">MVLTATTLDDARKIWETQTGYFATPSHSDYHHRDPCKNFFIGGPLSARAETDKPGENSSSSSSSKLAQTTKTPPTDISTTATVKETSTHKQSSQPRPPPTSSPSPTISPPSSTGPPPTTTIASTTPTPTDSGASDSNGVMTLSISALVGIVVSCVIVFLFAALSAYMWWRRYRRDKAKKDQEEQVQRGVFRWESRGAGQRQDEEDQFPSGMDSVFDPMAQAGPGSVFDRAQGRMGSVDVMLNSRPPTSSHDPISPASGAPASSSSNSPLAITVHPQTFSLPTSPVELDSVPVDNQRDMDVAGAAPTHPANNNKTTTKPETNSRRSWVGEGSLVPRATLNATEREMEAGMYANSWSRFQGVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6F5</accession>
    <name>A0ABR3V6F5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000304">
        <property type="protein sequence ID" value="KAL1837342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="516" mass="57333" checksum="D8FFF63EA4603A31" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6I9</accession>
    <name>A0ABR3V6I9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoketolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000301">
        <property type="protein sequence ID" value="KAL1837373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="606"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="92703" checksum="88FF1BB319CBD577" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6M8</accession>
    <name>A0ABR3V6M8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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    <sequence length="1207" mass="132497" checksum="7FD6BB98A1364A28" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V755</accession>
    <name>A0ABR3V755_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_3759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000292">
        <property type="protein sequence ID" value="KAL1837460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="43"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="564"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="725" mass="81322" checksum="C95B88047D0AF873" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7G5</accession>
    <name>A0ABR3V7G5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000267">
        <property type="protein sequence ID" value="KAL1837733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF3">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047443935" evidence="4">
        <location>
            <begin position="28"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1175" mass="130468" checksum="9F42F43616C82CDA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7J5</accession>
    <name>A0ABR3V7J5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000267">
        <property type="protein sequence ID" value="KAL1837726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046540088" evidence="1">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="162" mass="17101" checksum="9C13EAB19FC1C6B3" modified="2025-10-08" version="1">MVASALALSLIGISAVQALPTSKTVTRRQIWLGDGSTVLIPGSEETPPQCLVDLDGKPIKQQPPCLLPPITGPIQPSTKKRQASKRQVIIGDPTTIFIPGQGEFPVCLVDVPLKEQPPCLLLPIPGEITPSTKKRQAIIGDPTTVFVPGVGEVPVCLGYQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7U2</accession>
    <name>A0ABR3V7U2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_3357</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000259">
        <property type="protein sequence ID" value="KAL1837829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="205"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="364"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1837829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="618" mass="67507" checksum="E2FC334F7449552A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Y7</accession>
    <name>A0ABR3V7Y7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000256">
        <property type="protein sequence ID" value="KAL1837874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="135"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="325"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="463" mass="50519" checksum="BFF2ACB26BEBAFE2" modified="2025-10-08" version="1">MPLGDSNPGNNPSMLDAEEPGKEVCFDTIKHCNRRGQLPEDILPLYADLLPILRYGTGIFPQEIRAKLSTLSSLELPPSVLVRGLRRPKPDPKTGGNRPGQDVTQAVQGEAFFDGLPLSVLFSGTAEGASVESRIENAEFYKLRAIVERAKECSKLIRGADAWKSKVDEPLLELAFSRHHKGVTLENATSARLIPSFVPSRVLNRPVPAEIARGRTVDFVVSPTISPDSKLGSAIHAKLVSLEQDTPGSSWAHPTLNPTDYPPLAWSPVAMAVGVGINPSDPTPFLPPPESRPPPIPWEEWCNRPSFWESYRKQLWAGAIRTTDVEQQLRLWVVAWHKRMEMLGIGGRQGPALPTLILINVQDHNWFLSFAVDRLDKIEILGGSELIGGTNTLVGVYKLVTVLRMLAGWIDTTFRSWVEKTFGPQATIALAQAAETALVQAEAEAGSGADADADAEAEADAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8G5</accession>
    <name>A0ABR3V8G5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_3026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000238">
        <property type="protein sequence ID" value="KAL1838095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="460" mass="50165" checksum="9FA86AC078AC27F1" modified="2025-10-08" version="1">MLVLFFVALAGLSSLTALLLYLVFRPTRYDGPPAGSSTGVSVHIVVLGDIGRSPRMTYHALSIAKHGGKVNLIGYAGNAPHPDVTTNPNITLTPLPTPPRRPPSIPFILFAPFKVLYQLYHLTRLLAYTLPPAQWFLVQNPPSIPTLAIAILVCRLRNSKLIIDWHNYGWTILAGTRGSSHPLVRLSKIYECHLGRLGDLHLTVTHAMARQLRRPPYSIPEHLPMLVLHDRPAAIFQPLPSPTAREAALHRILPAEHRDLLPALCRGDVRLLVSSTSWTPDEDFGLLLDALVQYCSASPPPAPVLAIITGKGPQQSFYLTRIAELASQGRLPREIVRVATAFLPFEDYAALLACADLGVCLHKSSSGVDLPMKVVDMFGAGLPVAAYQGYESFGELVKEGENGRGFETAEELAGVLGRLFSEEGKAELDGLRKGAVLEGSRRWDGEWEASVGRVTGFVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8U0</accession>
    <name>A0ABR3V8U0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000261">
        <property type="protein sequence ID" value="KAL1837811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="273"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="420" mass="44633" checksum="CAF0F84A4E326D74" modified="2025-10-08" version="1">MADYPAPPGPAGAPTNGPNGAAETTFPPAPPIGPNNEASKTLWMGEMEPWMDENFIKNVFQTVMAESVQVKVIRDRNSGNAGYCFVEFQTPEAAQKALALNGTPVPNSTRVFKLNWASGGGLVDRRDDRGPEFSIFVGDLGPEVNEFVLVSLFQSRFPSCKSAKIMTDAMTGQSRGYGFVRFSDEQDQQRALVEMQGVYCGNRPMRISTATPKTRSHQYGGHGHGHAAPNPMIPPVPGHPGGPMWGAPPAYYGQTAPYSPMQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVHRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGVGTPYRPAPPPPHYLSGMPPHGGPAGPYGGPPFGATPPQGPGPFGAPAPQGPGPFGGNNPQGPPPGGPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9D8</accession>
    <name>A0ABR3V9D8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000213">
        <property type="protein sequence ID" value="KAL1838449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="64125" checksum="4797F9DD6622F551" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9P6</accession>
    <name>A0ABR3V9P6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000207">
        <property type="protein sequence ID" value="KAL1838568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045949337" evidence="2">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="185" mass="18986" checksum="D76AFBB235FBC95D" modified="2025-10-08" version="1">MKKLPWLLLPVLLGGGAAPAAAATSDLGKAAPGHDAVVNHPHNLLLNRGIAYPPQDKRASASSARADDVPRDQDALTIAVSVSLPNQTKPKTRAPLPPRVHEQQVPAAPPPPDRRDGLPVVITSRTPSSKSSASRNADSEPPGADHDQAGASSAGEAGNPASANRAIAGMSVGLVSVMLFFTVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9W2</accession>
    <name>A0ABR3V9W2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="35"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="256" mass="28940" checksum="F719EFEA479E411A" modified="2025-10-08" version="1">MAPVYADHPFQLLQTPVYLAKQRDEKTDLFDELASEMVHVHNMIIRGLNSIYLQAPHIKTADEKAFCRYILGWHTLLHEHHDGEEEMLFPYVEKATGVKGIMEANISQHKDFHESLDAVKNYAEAVLSGTEKHSGDKLVAILDELGPILTGHLNNEIPTLLSLRQYADKLADLPRLFEQEGEKTMKKIGGAGMVFCFANIDLGFEDNMWPNFPPAPAPVKVFIKNVLWWVHPDVRKFGAVDRSGKLRPLYAVPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA65</accession>
    <name>A0ABR3VA65_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="763" mass="86721" checksum="6E5A1959E0114965" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAG7</accession>
    <name>A0ABR3VAG7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="193"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="389" mass="43310" checksum="E1745D83B15F2DD7" modified="2025-10-08" version="1">MTSPTEQPPAPSDTLSIADVVFTEATPHQRILSWTLNGASWAGNMTLDQHIGRETALSEAALSANGGTTYFILHPRDDPETIVSACEVTRKRACVLSGEDGGNQPREVTAYGIASVFTNPRFRGRGMASHMLRKVQEFVDNELKAEFGALYSDIGREYYTRLGWRDWRTPQLLLTLSEAKRDGGGGSSATLSANGSVPIYEEDVRKLAKEDIQRVKDSLIASAKRGNGGDKTRIAFLPHTEQFLWHFTRDRYMCKVLAGREVVNRGAKTPDSSAWVLWDHDLRERKLKVLRLVEDTAGTNSDDKRRADVKTLLRAAVAEAADWGLPKVSVWSPSGVTATAAADLWCELQPRVQVALEERMDGSIPSLRWKEDKPVDDVIWEANEYYAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAH3</accession>
    <name>A0ABR3VAH3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VPS4-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000218">
        <property type="protein sequence ID" value="KAL1838381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21752" checksum="185B7BC249C64E22" modified="2025-10-08" version="1">MSFPNVYMHRKVAEAKARSCDICYRLSSSVLITPDSKDWFYVCPAHLKDTGFCTPIIDQAAIEARKERELREEIERVKKEYEEKQKKKKEKSEKGSKDETDEKGDKKNEGEDEKQQQARDKPDTTSDDTATSPAREEEEEPRVFELKSTFYQLRLNKKRQAEVARRNRERMQDPNYFPSVPKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAN2</accession>
    <name>A0ABR3VAN2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPX2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000193">
        <property type="protein sequence ID" value="KAL1838783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="72526" checksum="AC80A37198E35734" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAT3</accession>
    <name>A0ABR3VAT3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000187">
        <property type="protein sequence ID" value="KAL1838895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="134"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="601" mass="64705" checksum="516D1BCEAFF0F9E6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB69</accession>
    <name>A0ABR3VB69_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000183">
        <property type="protein sequence ID" value="KAL1838963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="154" mass="17340" checksum="B2B11B6069010B43" modified="2025-10-08" version="1">MLHGQYTPPMHQDDYFFPPSGYDTATGRERSHTPPMFTYSTYPAPPAPEDMAIPPYDTVPGYTHQPYHRESSYPEYLSPPPVPVTLPSMTHFTDAIKREPGYPEDTLPSYMSYQSYSIPGVDISSAAHPSPYDHMPHVSCHFPALPSQKEEHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBF0</accession>
    <name>A0ABR3VBF0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000171">
        <property type="protein sequence ID" value="KAL1839175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="161"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="615" mass="68825" checksum="387721EE771B8FBC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBH0</accession>
    <name>A0ABR3VBH0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ-loop repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000177">
        <property type="protein sequence ID" value="KAL1839061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27146" checksum="8F101B58EF1AF989" modified="2025-10-08" version="1">MGWLTTLSGWITPAFLVLSPILSYSDQAYSMYRTRSSAGFSLDIPLIMLVASLLRIFYYPGAKFDRALLVQSFVMVAMQVILLKIGLDHRPPPYSKGGDAAMPFARVHETRRPFNFWQWRSPKPYWQFLVSLFMGLCLCEFLLAPLPWIYSSYSPLIGFIGLGVEAVLPIPQILANMRSQSCKGFRVSVLASWLVGDAMKMFWFFTSKTTIPWAFKVCGMFQACCDSFLGIQYVIMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBJ9</accession>
    <name>A0ABR3VBJ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000180">
        <property type="protein sequence ID" value="KAL1839005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="57"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="416" mass="43044" checksum="16A0A97C9CAD110C" modified="2025-10-08" version="1">MQSLGGTRKRKSDQLDMSSDAHFAADPLTQTVPTKTDMSHPDEGPAKRQRVGLTLAQKQALIDNLQLEITERARKLRANYNIHAQSLRTRIEIRVNRIPLSLRKLTMGELLERCAKEVQQKPSLLTSSVRGPPVPAKDVPVSRPPTRGGAAPAHPPKRRSHEISGGDKENEIRTPPKKARADGPSVVRNPNSHVLSPTTVNSRVAPRPTTAGAPTPARPGTSSGRPAATPGRAAMASTILNRMVDSTRNGPAARSGAVTPGPATGRKTPGPGAGPTSSAITASERRRRGATVTAAVQPPPSNSRPLSQIQQTARRVSGASESSNVSEGSTSTVIRKRPMTAPPGSQPKLLSLAGGSTQTSTAAKRTTVMGSIKKGVASAVGTAGAKKGGSVGKAAGAAVAGTASGSAAGRVLRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBS1</accession>
    <name>A0ABR3VBS1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000165">
        <property type="protein sequence ID" value="KAL1839294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="616"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="900" mass="101645" checksum="6FCBED901B835E2C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBW2</accession>
    <name>A0ABR3VBW2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000163">
        <property type="protein sequence ID" value="KAL1839333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="681"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1066" mass="118387" checksum="0FF9D7D20BDFA621" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBW9</accession>
    <name>A0ABR3VBW9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000166">
        <property type="protein sequence ID" value="KAL1839277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="451" mass="49920" checksum="FEF8DC697B56553E" modified="2025-10-08" version="1">MTASKTPAPLVSEPAEPGSKSKDDTAVWSLKHIQVLWSWAARPKPVQPKYPPISSIPRTSADRLREPDVAPTPFPAEPIRASEFHQDAPTKPKTVLYLAYGSNMAAETFLGMRGIRPLSQINVSAPSLDLTFDLPGIPYREPCFANTAMRKIPGKKPSFDPPEFPPGAPGRPPRQDDLSASRDKNTRDPVWTKGLYGVVYEVTPDDYARIVATEGGGASYHDILVPCFALPPTTTIHVPEQPTHQPPAPFLAHTLYAPRLPAEPPQTIPPLPGFLRRLLLPTRRPEATHAQPSLRYLNLLRAGAREHDLPPDYQAYLGQLRPYRATTRGQRLGQVVFLGFWLPPLVAVMMSSRIFADEKGRAPGWLVVASTCVFNLIWTSYDWVGKRVFGDGERSVEDEEEGEEEEERREGKGREGMNGGKKGRRESFASGLRGVGEVADEEKVALLEGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBY8</accession>
    <name>A0ABR3VBY8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000180">
        <property type="protein sequence ID" value="KAL1839012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47994" checksum="A5479BA55E67D701" modified="2025-10-08" version="1">MVSNGTPEKTAPGAGPDQLEAAFGRPLALASRSIHADDYTNTHPAVAPPMHVSTTFRYPRNPDELVPWSEADPDAFENFYIYSREKSPTTTRYEALLTSLLGGPAISYASGLAAFHAMMVFLNPRRVAIGGGYHGCHGILGLLHKLNGLETVELEDEAALAARLRPGDVIHVETPLNPTGEARDLEYYRRKADELGCWLTVDATFAPPPLLEPFRWGADVVMHSGTKYFGGHSDMLSGVLAVNPKRAGERTVPGRKGGGESKLTWVQQLREERLLLGGVMGNFEGWLGVRSLRTLELRVKRQSENAQRLVEWLAEEKGKGEGVVAELVDRIQHSSLQPEAADKDSWLARQMPNGHGPVFAVWLASEPLARRLPSKLRLFHHATSLGGVESLVEWRAMSDATVDRRLIRVSVGVEAWEDLRDDLLQGLQALKEEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC39</accession>
    <name>A0ABR3VC39_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isovaleryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000165">
        <property type="protein sequence ID" value="KAL1839301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="90"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="205"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="314"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="50908" checksum="DA4C71D675FFCF0B" modified="2025-10-08" version="1">MSSTTIPRVALSRATRATTTTRRLNFTRGIAYAAAPSRPTPRRGEQNAATTPSAPSPAVSTPSTLLRRPEQRRHASSKHPKGFVPPTSADLAELRERVQEFTRRELTEEVAAAADKSNSFPDGMWRKLGDAGLLGITADEDVGGLGMGYQAHCVVMEELSRASGSVALSYAAHSQLCVNQLQLHGTPEQKQKFLPALIAGERVGALAMSESGAGSDVVSMRTTATEVPGGYVLRGSKMWITNGPDADVVIVYAKTLPDAGSKGITAFIVEPKTSPGFACLRKLDKMGMRGSNTGELAFDEVFVSRENVLGPLHGGVRVLMEGLDFERLVLSAGPLGLMQAALDVALPYAHARKQFGTPVAQFQLVQGKLADMYTKLQASRAFTYATARAVDEGATAGAAGGAGSSLSRDCAGAILYAAERATECALDAIQILGGMGYTEDMPASRILRDAKLYEIGAGTSEVRRMVIGRSFNKEYAHLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC51</accession>
    <name>A0ABR3VC51_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000184">
        <property type="protein sequence ID" value="KAL1838951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="44936" checksum="E81563487451B920" modified="2025-10-08" version="1">MNKTRVLGSLKSIFPPLHQPLPLDKRECQRLLDAIKASFREQLDREHGFATSTPNRSSLPSQPPRITSLHSSNPTQAPSDQIPTRPTDRHMHAILRNPLFNPSSASEPPGGYSNALDRHKAIFEKAVSRGLMNLTRAHGFLEQVYVDTKEGLRPTGVGVLVAQWLRSSGQDRDLSFLSNVRFARLLVRFVVADGLDDLVWSWFERLITKLDAPSSAPSPTAAYVIDLLVFRKYLAPEPDQAYAAMLKAETIVKEHDVDPRVLHRAWSKLAFHTTMPSTIVRRQPPVDLFDPFVAMGEEVGSTPVEMAHLDLHHPAHPSADRAVEYLSNEDSYKTSDANPQPSPSRYLARLRWLGLDTVQHLIKENETREAARVWSLLQRHLGNMSLGFRDPAHNNPGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCL1</accession>
    <name>A0ABR3VCL1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_1456</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="609"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1839481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="639" mass="69777" checksum="C08127B934D39793" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD40</accession>
    <name>A0ABR3VD40_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="437"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="544"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="662" mass="73460" checksum="79BB00989E4C23AC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDK8</accession>
    <name>A0ABR3VDK8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sphingolipid long chain base-responsive protein LSP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43460" checksum="76CE9B737869BFD3" modified="2025-10-08" version="1">MHRTYSLRSTRAPTASQIQNPPPPPSSTKSGRLFGKGGLGHALRRNTAGAFGPDLAKKLSQLVKMEKNVMRSLELVAKERMEVAQQLSIWGEACDEDVSDVTDKLGVLLYEIGELEDQYVDRYDQYRVTMKSIRNIEASVQPSRDRKQKITDQIAHLKYKEPNSPKIVVLEQELVRAEAESLVAEAQLSNITREKIKAAYAYQFDALREHCEKVAIIAAYGKHLLDLIDDTPVTPGETRPAYDGYEASKAIIQDCEDALTNWVTQNAAVKAKLSTRARTLSQRRRNNIKARSEGLQLQQQQGQQQPAQGHDLSAQDAPLNDGESWVPAGQHDFDDEDEDETEHSDDDLEVPSHTAVDTEASVNGEQAQAQQQQQQQTQQRGRNHDVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDL1</accession>
    <name>A0ABR3VDL1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000133">
        <property type="protein sequence ID" value="KAL1839964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="166"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="447" mass="49089" checksum="404B8472A1948783" modified="2025-10-08" version="1">MSTTNSPAQPGKRKRNNTMSIDVNPTQSAQTESRDASGEEGDTTAAESSRAAAAAHSHPPSKRPRPDSDHAVPATAAEKPIRHAQAVDPGEPSDTTEASVDIAERVGRKASRKSTSSKAEDSTINGSGIISNKTQAAMPPPPIGTLTHPKGYKTNPPPVGRPVRVYADGVFDLFHLGHMRQLEQAKKAFPEVYLIVGVTGDEETHKRKGLTVLSGKERAETVRHCRWVDEVIENCPWIVTPEFLEKHQIDYVAHDDIPYGADEGDDIYAPIKAAGKFLVTQRTEGVSTTGIITKIVRDYEKYIHRQLKRGTTRQELNISWLKKHELELKRHVQDLRDNIRSNWSTTGQELSKELRNFWPSSRPQSPARLPSSNNNHNPPSSPLGAGQGGSGFPFPRSPTGTGPTTAGERAMTKSRHASRDDESRQESEDESEDVVDDSGKYHSEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDM7</accession>
    <name>A0ABR3VDM7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="119" mass="13641" checksum="9B6C05C7DB88E34A" modified="2025-10-08" version="1">MAQYPPNVGHDLINYSYFGVYQPIEPPNAPTDRPAAMARILARLKQHSPLMAMKAVTLSAPSRVSQGEKFLRNMGELDQHPLMLEDRERQMHGPSEDPERSFFDRLQVEIPDVKDHFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDV7</accession>
    <name>A0ABR3VDV7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1334</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000149">
        <property type="protein sequence ID" value="KAL1839591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="124"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="519" mass="57377" checksum="ED91AB2C2F31FA74" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDZ4</accession>
    <name>A0ABR3VDZ4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="90" mass="10254" checksum="2862A57A39B43F92" modified="2025-10-08" version="1">MADVDFESTGWYSWLVNLGILPGESHYIIRFISSFFISLAIAPIIPVVLMFIYDVSLWLWRITTAQLRRRHAQAVAAAEMQPPARISDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE35</accession>
    <name>A0ABR3VE35_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000127">
        <property type="protein sequence ID" value="KAL1840104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="76"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="445" mass="48455" checksum="E531537E374CCF7B" modified="2025-10-08" version="1">MHQDDAGQNSEAARLGSAVRQRGREYCAAPDCQINYSTGCDAHQRPSGPDTAGVARPKVGNVPYGGAGIYSCINPGDVALTYDDGPYLYTNDLLDKFKAYGAKATFFVTGNNLGKGQINDPSTIYPAIIRRMHAEGHQIASHTWSHQNAAQLTNAQFTDQMIWNEIALNSILGFFPTYMRPPYSSCPSNCQNVLNNLGYHITYFDLDTEGYLHTDPSQIQVSKNIWNNAMSGANPNSNSFLQIEHDIHYQVVYNLTDHILSSLYSNGFRAVTVGECLGDPQSNWYRTGPSGSGSPTTTTASSTTVNPTRSTVTAPSPTATRVTTDATCGNGVTCAGSEWGSCCSVYAGMGDMRRWGGTEQPIDRHLEFLNDNNAKQHNVHEVNCPPFELELNHDADDAENHHRNTIDHPCITFGNCCGSDGRCTSNLLMCLSILGCQANYGTCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE44</accession>
    <name>A0ABR3VE44_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Succinate/fumarate mitochondrial transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1532</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000159">
        <property type="protein sequence ID" value="KAL1839401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="219"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36531" checksum="676E07C0F6834A0E" modified="2025-10-08" version="1">MATRADNGRKKPTSAATNLIAGGGAGMMEALVCHPLDTIKVRMQLSRRGRQPGMPRRGFIATGADIVRKETPLGLYKGLGAVLTGIIPKMAIRFTSFEWYKQLLSNKETGKVAGQALFLAGLAAGVTEAVAVVTPMEVVKIRLQAQHHSMADPLDVPKYRNAAHALYTIVREEGFSALYRGVSLTALRQGSNQAVNFTAYTYFKKWLYEWQPEYQGGNLPSYQTTLIGLVSGAMGPLSNAPIDTIKTRLQKMKAEEGTTALQRITRIAGDMFRQEGVHAFYKGITPRIMRVAPGQAVTFTVYEFLKEKLERSGPAILTGGSREQEFDSMKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEC5</accession>
    <name>A0ABR3VEC5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="665" mass="70430" checksum="8F6248EE392EDA70" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEZ8</accession>
    <name>A0ABR3VEZ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000116">
        <property type="protein sequence ID" value="KAL1840372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="2">
        <location>
            <begin position="704"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="869" mass="95284" checksum="DE4EDD99F3529763" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF27</accession>
    <name>A0ABR3VF27_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF97">
        <property type="entry name" value="ISOAMYL ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046499469" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="141"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="604" mass="65755" checksum="C75052E0DA06E4D3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF70</accession>
    <name>A0ABR3VF70_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000110">
        <property type="protein sequence ID" value="KAL1840510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="728" mass="81455" checksum="5698BB8113743FA9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFX8</accession>
    <name>A0ABR3VFX8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="120" mass="13687" checksum="3F60374927535051" modified="2025-10-08" version="1">MVKKRKNNGRNKKGRGHVKPIRCSNCSRCTPKDKAIKRFTIRNMVESAAIRDISDASVFAEYTVPKMYLKLQYCVSCAIHGKIVRVRSREGRRNRAPPPRVRYNKDGKKITPTQGPKTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFY6</accession>
    <name>A0ABR3VFY6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000100">
        <property type="protein sequence ID" value="KAL1840765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1327"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="755"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="921"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="954"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="544"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1043"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1090"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1049"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1209"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1395" mass="150211" checksum="3BD70510CC33917A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGV9</accession>
    <name>A0ABR3VGV9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="469" mass="50733" checksum="584264C8364FE13A" modified="2025-10-08" version="1">MASEADDIAQTVLDQFRKLPAKRKPAVRDNGLREWVPLSGIVVRGPNFSKCVALATGMKCLPAAKLSQANGVAIHDWHAEVLVIRAFNRFLLDECRRLVRDPAAESAFLRRRTAAELSPTTSPPGSWHRQPFAWREELTLHMYCSEAPCGDASMELIMSSQEDATPWEIPPTPSSSSLSPSPSPQQQQQQPQPPSQEQTPLLLGRGYFSRLGIVRRKPARADAPQTLSKSCSDKLALRQCVSLLSCPTALLVSPRGVYLSTLVLPASQRVEGACVRCFSASSSSSSPVGGTSGNGDGSRDDDGDGRIAGRMAPLKDKTWQGTGYGFHEMKISATEREFEFSRRGILASVAGGEEAKAKVKLTANNLAVAWTKDGEVNEGLVGGVLQGRKAFDVRGASATSRRRMWSAAAEVAALLGPGHAEIAGVLAKTTYGEVKKSDLLEGRRRVKEEVRREALKGWVRNIGDEGFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGW0</accession>
    <name>A0ABR3VGW0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_7587</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="492"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="703"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="865"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1840981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="886" mass="98702" checksum="DC7A2AC108352F0E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH76</accession>
    <name>A0ABR3VH76_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051357">
        <property type="entry name" value="H3K9_HMTase_SUVAR3-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660:SF13">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="207"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="420" mass="46928" checksum="40C5F3711D509C91" modified="2025-10-08" version="1">MPKTRATKKFLSPPSSSGSPPASDKFDASDKFEAFDWTGQNRFIVPGVTRIQTYRVDPSRWTHLTSKPSSSLPVSHSSGSDESSSSSSSSDNDAMDIDSPTRMTTRSMTHNGGAHTRTNVKGGKRSAPPPPTNPRPTKRQRTAASDETPSDSSDILPPEALPIMQLPRNLKGADVFCLNCGRTPSSGKCNINCYREFRNTHFVPAESKIHIRRTAPGTHYTGLGVYVNSDSTGFREGDYLGEYLGVILPPGAHETLESDYVFTLDGVIRQKGDEGGRRVTRSSHHEVAPEVYIDAAKYGNWTRFVNSACSPNVEALTEQAGRVRMVVYRAVRAIRPGEQLFVYYGKGYFTARRLKCLCPDDSEPHTPPEDTIYVGGKYSNVDDQIASTMQELRPALERLKRQEKQERERRERRMRRHRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHA7</accession>
    <name>A0ABR3VHA7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="78" mass="8313" checksum="734F8D3F1165EC1A" modified="2025-10-08" version="1">MEITTESFSQNFISREHLTAPGLDEALTLCAGTLQTLVVTLDNSSASQPHLGRKGDLEQPSCPLVRCPNGPSESVKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI07</accession>
    <name>A0ABR3VI07_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000077">
        <property type="protein sequence ID" value="KAL1841371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="104" mass="12024" checksum="6A5D2830AF6B4F5F" modified="2025-10-08" version="1">MHTLFNRRVHLLQRRRVKVRAAAWTWTDVDPRCVVRATLEREAPQQPPAMCDFTKNYYIYTSCVDPGAHFFHTSVDGSRQRACPKSPHERFIMLPGQCPLCHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI91</accession>
    <name>A0ABR3VI91_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Survival factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="55"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="217"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="41564" checksum="E3EF18D40E1D97B9" modified="2025-10-08" version="1">MFKWAQQQLANVAGTQEPIYGASAIKSVAEEAKTTPYTELTKDDLKWHALSSTSVETQTFYFMADNGQLAFCQVIYSNVAGIRVTCQFNCKIFTLDGSSNPHLWSSTPLSNHDFSEDKTAFYADNCAVELSADGTAYTIKSMADPQAIVNLTIKRTAPGFKAGTTGTTLFGTDLSNPWGSMRHVFWPRCVAEGTIMTKNGPIDFKGKAFFSHALQGMKPHHAAAKWNFCNFQGPTHSAILMQFTTPPSYGSTMVAVGVIAKDGEIVVGGCNSDAVHLKTKGDSENDWPEPTHIRYTWSGTGKDGKPVEAAIEGGLEDRLDRIDVMAEVPGFVKKIVAGAAGTKPYIYQYSPQKTKLSLKLQVGDQEVTEEGFIFSEATFISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIE2</accession>
    <name>A0ABR3VIE2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="10">3-ketoreductase</shortName>
            <shortName evidence="10">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_7174</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="13">
        <location>
            <begin position="588"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="12">
        <location>
            <begin position="1139"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1841337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1905" mass="208672" checksum="28D74702E0C2F895" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIN0</accession>
    <name>A0ABR3VIN0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. RimJ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF8">
        <property type="entry name" value="[RIBOSOMAL PROTEIN US5]-ALANINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="246" mass="26854" checksum="9B4A7D3F001CA457" modified="2025-10-08" version="1">MSTNDSSAPGPDPNPNQPPPAGSQTSPSPTPTPAPPPPPPPPPQPQSIPPELNPTNPFPEPTLVLTKSILRPLHASDAPALQRAADSPNVARFLSYRFSSPYTLPDAFQWIVYALRFRVPGYPEVIPSLGICDPETNTFLGGIGVKTREDVEKGCLEVGYWIGEESWGKGIMTEACKEYVRWLFKVYPGVNRLEAGVFSGNDASVKVLERAGFVYEGTRRKAAVKHGEVFDIVMYGLLREECEPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIN5</accession>
    <name>A0ABR3VIN5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000067">
        <property type="protein sequence ID" value="KAL1841692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="303"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="963"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113765" checksum="F96B0111DC54B778" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIT0</accession>
    <name>A0ABR3VIT0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="105" mass="11370" checksum="C5CC4A898D919426" modified="2025-10-08" version="1">MMSDDLMSDPINPAEGPGTSDGKQAAKGSAAAAWNTKKFREDYLMAKNKLLDQKFSVSEYPDPLSPRPPHPKQYPPGTNPELERKLQELIARVKSSTGNGVVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIV4</accession>
    <name>A0ABR3VIV4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000073">
        <property type="protein sequence ID" value="KAL1841502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="247"/>
            <end position="327"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="688" mass="75755" checksum="366122493A95D7E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIX8</accession>
    <name>A0ABR3VIX8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000067">
        <property type="protein sequence ID" value="KAL1841687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="289" mass="29411" checksum="BBB58837ED87D498" modified="2025-10-08" version="1">MHREINANGFFQNEANTQIQQAQGQALTVTQTALAVVGGIIGSSLLTGVAFILIIRYRRNKRKQFGGSGSRRQDRNNGGAAIGYPQLTATSNKAYSISRSSSSSSSVSSSILKRGYFAPPAAGDATGRDDRRSSMYSTDTENNGFRFGTGAAAGIQPPAPAATVGGGGPVGYTVGINNNKGGGFKLSDPPPPRGAAVKAKTAAAATAAAAEGGKFSLFPSSEKDPGPPGSAGQAQAKSRVGSVLSSAGMPSLDKWLRDGTNVSPFATAVKNGNRRSAGSENSLGIGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ77</accession>
    <name>A0ABR3VJ77_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="237" mass="26305" checksum="D0BD7ADE7623CA35" modified="2025-10-08" version="1">MVRDIKNAPDGSIFLFHACAHNPTGVDPTPEQWREIEAVVKAKGHFAFFDMAYQGFASGDIHKDAFAVRHFVSQGHNVCLAQSFAKNMGLYGERIGAFSQVCADADEAKRVDSQIKILVRPMYSNPPIHGARIAAEILNTPELYDQWLVEVKEMADRIITMRALLKENLEKLGSKHDWSHITSQIGMFAYTGLSPEQMEALAKEHSVYATRDGRISVAGITSENVGRLAEAIFKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJD4</accession>
    <name>A0ABR3VJD4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ER lumen protein retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6793</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48423" checksum="0560D7DC11273486" modified="2025-10-08" version="1">MSLLSIRFLKPASLRAGISSRWPGPYVTTLIPPRNQQHPLTASLVIQIFRIAADLSHITAKCILIFSIHRNRSSEGVSLLTQLFYALVFVTRYTDLFSESYAWNYFFKVFYLLSSFYTIAIMRFVYPRTREREIAWKMSALILAGSLVLSPFVMLIFDPKDWWGFREWLWVFSQVLESVCVLPQLLLLRQTTIPTVITSFYIVFLGSYRALYLVNWILKELDTNMKKPNPISVIFGVIQTAFYVDFAWVYWSRQRVKLRNGGVVDADDLSRGWLLRRIFGSKPFSRDIDGPGAEDEENAPALGGSRGRGLGGSARGGARPKWGSRGISISADEGVLEHERARQGSDAFGDSDDDDEEHGVTTAGTVDPDAKMRDPDELARALDEDDDDEGVGAGSSSSRPEQQQQGQQQQQKKKDSPVPGIRGGDEWDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJJ4</accession>
    <name>A0ABR3VJJ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent bile acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1062"/>
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        <location>
            <begin position="1117"/>
            <end position="1137"/>
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    </feature>
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            <begin position="1192"/>
            <end position="1213"/>
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    </feature>
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        <location>
            <begin position="1219"/>
            <end position="1239"/>
        </location>
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            <begin position="339"/>
            <end position="675"/>
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    </feature>
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        <location>
            <begin position="711"/>
            <end position="960"/>
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        <location>
            <begin position="1042"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1398"/>
            <end position="1677"/>
        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="968"/>
            <end position="997"/>
        </location>
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            <begin position="1542"/>
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        </location>
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            <begin position="72"/>
            <end position="81"/>
        </location>
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            <end position="1729"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841897.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1751" mass="192276" checksum="9559EC0EC5878920" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJR4</accession>
    <name>A0ABR3VJR4_HUMIN</name>
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            <fullName evidence="2">Clr5 domain-containing protein</fullName>
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        <name evidence="3" type="ORF">VTJ49DRAFT_6650</name>
    </gene>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Drula E."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKR6</accession>
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        </submittedName>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAZGSY010000051">
        <property type="protein sequence ID" value="KAL1842192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="420" mass="45813" checksum="72ADDA8C75B0B380" modified="2025-10-08" version="1">MPPVNHAVLASVGIVVASVTVAAAIAIYEIPEVRRAAEDLRRRIAIALHALGDNVDPARQQQPRFNRPEDAEGFYQSHDVDADEETRRRQREELMYWNMRREQQLREQTDSRDRPPGQTFDDILEPDHARSPSGTLVYNTGSNTRDLDSSNVLRRRGNPEGVRGLNAAALANPFSDEYGIELEDRPQLPSPPRDEVMSDIYDATPLVQSPQLQHNQPLAVLSPVPVPSTSEVLFDYESHPASEYGTTLSTADGDAHDEQQKSRPATPDRASTPTAATPSARSATLERELADDEYMTAGQDRTVADAYESIQAWARGSSSHSFYENNQQSQHYNGGASFYSPLPHTPQAPMSEPELVSEGQLTPTSTDSASVVDVATAAAAAAVHDRSDEVLSETDGGIPTPASWSDVGSVVSESESAWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKT9</accession>
    <name>A0ABR3VKT9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="7">AK6</shortName>
            <ecNumber evidence="7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="7">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="174" mass="20145" checksum="63E8A9658DD6377C" modified="2025-10-08" version="1">MSRTLPNIIITGTPGTGKTCHSELLAERTGLKHLSINDVVKEKECHEGWDEEYQSWIVDEDKLLDAIEDEVKQGGYILDWHACDLFPKSWIDLVVVLRVDTATLFDRLTERKYPEVKLQENIDAEIMEVLLQEAKEAYDEEIVVELQSVTADEMESNVDRIVQWLEQWKKNNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKU8</accession>
    <name>A0ABR3VKU8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="168" mass="18513" checksum="0A1973E0D6BAF67B" modified="2025-10-08" version="1">MKAVMLPTFTTRPLMTNSPIRQSLSPEEQRLFRLYGKLPSRSDHFAKHLKERKYFDSGDYAMNKAGKGNSVDTGAVGSQHPLPENIPHLTSPVMGPNGHHLSISSGMQMHPHQHSSLAQTAGSPVKESSSLNREASAEDLEEGQDEEQQKQESVTAEQQQQQGVPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKZ8</accession>
    <name>A0ABR3VKZ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="113" mass="13047" checksum="03DE1E9629B065B5" modified="2025-10-08" version="1">MRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLA1</accession>
    <name>A0ABR3VLA1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF112">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="438"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="699" mass="76838" checksum="275C3A4C461AD53F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLD8</accession>
    <name>A0ABR3VLD8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="402" mass="43651" checksum="67C54C59C7B9FB0E" modified="2025-10-08" version="1">MDRIRAWFSPAKASADDYEPLAGNEPGSLEDAMSHEQGKPPFSWLEYSVFALIGVAMLWAWNMFLAAAPYFQIRFQSDPWIYDNSQSAILTTFTVVNLASMLLLANLQAKADYPFRIITALVISGGVFALLTASTTLFVNASPRGYLIFLLLMVALTAGGTGLMQNGAFSFAAGFGRPEYTQAIMAGQGVAGILPPLTQMLSYLAFSDSSASSPSSTPDQPPLPPPPPEKNQGSTSAFIYFLTAVLISAITLTAFIPLVRRHARATLRLRNSTTTTTTSEPESDPDTPPTAAPGHRHVPLLTLLLKLRWLAAAVFMCFVVAMFFPVFTAKILSVRDPMDSGRLFSPGAFIPLGFFFWNLGDLAGRVSTALPALSAPFRRRPKVLFGISLASVKKREKRLINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLW0</accession>
    <name>A0ABR3VLW0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="169" mass="19635" checksum="3851ABA9544FC502" modified="2025-10-08" version="1">MSQSLRPYLQAVRSTLTAALCLSNFASQTAERHNVPEVEARTSPEVLLTPLTIARNENERVLIEPSINSVRVSIKIKQADEIEHILVHKFTRFLTQRAESFFILRRKPIKGYDISFLITNFHTEEMLKHKLVDFIIQFMEEVDKEISEMKLFLNARARLVAESFLVEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLY2</accession>
    <name>A0ABR3VLY2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_4138</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="729"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="415"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="541"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="941"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="953"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1842809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1089" mass="117982" checksum="DA8291D27E8752C6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLZ1</accession>
    <name>A0ABR3VLZ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_4360</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF3">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE AN0832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROLINE_PEPTIDASE"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="15">
        <location>
            <begin position="65"/>
            <end position="200"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1842722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="572" mass="62797" checksum="FF531DF1B5FBEE35" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM04</accession>
    <name>A0ABR3VM04_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1842418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="743"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="857"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1189" mass="125908" checksum="863C0D2FEE2E4566" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM97</accession>
    <name>A0ABR3VM97_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="91"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="387" mass="41236" checksum="82738DE884BE583A" modified="2025-10-08" version="1">MDDDEYGDADDVLTALADAHANSSRQQQQPLPPQPRPVSRVQPIQQPVPQRLDRPPPPAATTSPAPGGSAAKPVQPTPQVLPTGGRGSGSSILVSPRQKGNPVLACLKSVPWEYSDILADYGLGLTTCALFLSLKYHRLHPEYIYTRIRNLQGKYNLRVLLTLVDIPNHEDSLRELSKTSVVNGVTVVLAWSAAEAARYLELYKAYEHAGFAAIRGQQAEGYAERLVEFVTVPRNINKADAVALVSSFGSLRHAVNATPDQISAVSGWGEKKVRAWCKAVEEPFRVRKGWRMKSQAQAGREVSSSRAQGAGRSTGREEDNKDEDALIAAAEAEGTSSGRPSKSAPSRETPAATGSGSSGSGGRSAEGGDEALSEGVAAALARLRNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMG4</accession>
    <name>A0ABR3VMG4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="65"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="877" mass="94537" checksum="E5E7E2E57CEA839C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMS4</accession>
    <name>A0ABR3VMS4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="696"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="700"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="740"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="893"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="742"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114625" checksum="EE28FE6CA8432365" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNQ4</accession>
    <name>A0ABR3VNQ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="10">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="103" mass="11400" checksum="58E15B0E75674405" modified="2025-10-08" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRTVLKSFLEGVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP09</accession>
    <name>A0ABR3VP09_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="1251"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="728"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1292"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1463"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1130"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1292"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1573" mass="171693" checksum="931A4B1B579A63EA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPU9</accession>
    <name>A0ABR3VPU9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="2">
        <location>
            <begin position="40"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="373" mass="39873" checksum="1802883D98AD18D8" modified="2025-10-08" version="1">MFARSFATSARRLAGVAAAAEPSPHLIAVAKAQGIAKGLTGAIGNTPLIRLNRISEQTGCEVLGKAEFMNPGGSVKDRAALYVVLDAEERGLLRPGGTVVEGTAGNTGIGLAHVCRSRGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFENPENYNHQARRHAESLDNAVWTNQFDNTANRRAHIETTGPEIWHQTGGKVDAFTCATGTAGTLAGTTRYLKEISGGRVKSFLADPPGSVLHAYVSSGGKLLERTGSSITEGIGQGRITDNLKPDLELLDGSLHISDEKSIEMVYRCLDEEGLYLGASSALNVVAAKEVAEKLGRGHTVVTILADGAYRYADRLFSRKWLESKGLLGAIPEHLKKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ20</accession>
    <name>A0ABR3VQ20_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromosome transmission fidelity protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38996" checksum="F847317C3EBA94DC" modified="2025-10-08" version="1">MAAPTRSRLRCSFHGHASWVPATCALRPWTTTWPAIDRQRRQQRRRLHSYPPSAQPPRTVVPSSSRSRPLTTLLSTPTNPRLHDEVALFTSHPPLLSSDPNHKPDDRKVKLGKTLRILQSHLPTLLQSPLPQQILSPQITLHLFPSTHPHLPTVTGRVAYIAALWSSPIAWNRVPLVGNVRLEILSERMVDGPACYASLPGGRRPEGAVGEQLIVRWRTLGGNGGKLRSWLGFDGGKGRKEKKEREAAAAAAAGDGSTTATPGPAVTTETEYKAPVGSALPSGSSNKEFTGLFIFDFDSEGRILSHTIEHVQETGQWEKGVGAKVVGLTDWLLGGIKGGDAPCPAFARERWDRRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ31</accession>
    <name>A0ABR3VQ31_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1844020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="418" mass="45294" checksum="4346F5C367E7690B" modified="2025-10-08" version="1">MARTKQATPLRREPSSEYSVRNRDTGATEKVNGHVANGNGKDLAAAESKTPAAVSAKKKAGIVTLVIDVAGIYASFLTWAYLQEKLTTTNYTSPSSSTPERFKFPVFLLTIQSLFAFLAGKLFSILTTPRGQPAPALIPHRDMLGPLLLVAFTNALAAPFGYAALAHIDYITYILAKSCKLLPVMVLQVTVFRRRYPLYKYLVVAAVTCGVAVFTLHSGSKKAHAKAASHSGQTAWGMLLLGINLLFDGLTNSTQDYIFQTYRGYTGPQMMAANNLLGSAITGGYLVLSPWLVHTPLGEWFGMDLAGRAGELKAALAFLARHPAVWRDVLGFALCGCVGQVFIFHTLSTFSSVLLVTVTVTRKMFTMILSVIAFGHRLSRMQWLGVALVFGGIGVEAQIARREKLAKEAAKKKAEKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQB6</accession>
    <name>A0ABR3VQB6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2886</name>
        <name evidence="4" type="ORF">VTJ49DRAFT_4334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000335">
        <property type="protein sequence ID" value="KAL1837045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="3">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="228" mass="26043" checksum="73956C350C3E7332" modified="2025-10-08" version="1">MGREEQVEEREVLDSIFPEEITDISETEFRISIKLDLPDDVEGEPPILLLTVRYPEEYPDKAPFLELCAPQNSTPHEYLNVAEDKEQLLQGLEATIEENLGMAMVFTLVSAIKEAAEQLIESRKEAAEKAHEEAILAAEREENKKFHGTPVTRETFLKWREAFLKEMEEARIREEEERAAELKKARIKEPVKLTGKQLWQQGLATAGQEDDEDGIPVDEVQKLKVGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQK9</accession>
    <name>A0ABR3VQK9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="492"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="727" mass="80491" checksum="87A049B743F363AD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQW6</accession>
    <name>A0ABR3VQW6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="257" mass="28898" checksum="02835E3586546944" modified="2025-10-08" version="1">MDDYFPYTPEPFTPLEIVLTLQDSWVAGPETQQQRHDAVLSMLTGPAEPGGGCGLLIREAREVMLRAAAGILQLLLAAKVEPREVGQEAFDLIVWAYVYERVASNEKIATQTFPWKHETIAAIIDHLVNVNGNSPPAEAYRVFCVNMSRRRAVIASIARRTEVPRRGHKIQPLNTAAPSRHGKDSHQQENTSQVGEDALAAVPIDPTLERFGRMLEFSLTSVKFDASAYPRFGEREAYRKWFHELMTAFLGPEYYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRB3</accession>
    <name>A0ABR3VRB3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cell division control protein 42 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21598" checksum="103AEF50681CD1C1" modified="2025-10-08" version="1">MVLGTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQVDLRDDPAVVAKLAKQKMAPVRREDGERMAKELGAVKYVECSALTQYKLKDVFDEAIVAALEPPPPKGGKKSHKCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRU8</accession>
    <name>A0ABR3VRU8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_65</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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            <strain evidence="4 5">CBS 620.91</strain>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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</entry>
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            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V221</accession>
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        <name type="scientific">Humicola insolens</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
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        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
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    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
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        <property type="entry name" value="6PGDH_NADP-bd"/>
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    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="NAD_binding_11"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="225"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1835441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="357" mass="38185" checksum="281BC20CB185CF15" modified="2025-10-08" version="1">MKNTVRLWRPVVCAQRRGFATTSRRLDNYAFVGLGQMGYQMARNLQSKLAPSDTISVFDVNAAVAEKWVQEAKTQQPGGAAPRVARNAGDAARDALGQLAGLIVIIDTIITCLPEPKHVKSVFDCIILTLNALQSGEMITRPKPRLFIDCSTIDPTSSRELASAVKAALPNGRGNFVDAPMSGGVVGATAGTLTFMLGAPKCLLGRIEPILLRMGKRVLHCGSQGAGLSAKLANNYLLAIENIATAEAMHLGVKWGLDPKVLANVINVSTGRCWPSEVNNPVPGVVETAPASRDYAGGFGIGLMRKDLRLAMLAAKEAGAELPLAEKASEVYETAEADERCKGRDFSVVYRWLQGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V281</accession>
    <name>A0ABR3V281_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000518">
        <property type="protein sequence ID" value="KAL1835874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="262"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="509" mass="54288" checksum="04307650F7530C62" modified="2025-10-08" version="1">MSFPVSGHAGIDPNDLASGNYQTSFQNNFNNNGLNAFSSGSAVLGDDELLDGLPMDGPTTQDFGGVNEMGVAFSHGVYGSHHGLPINQQPYSSTPDGDPIQSPFVSSFGYRQMQHPQSFGGLKSPLSYAGSPLANEMNEHDSNFINARARIAGAMQQKPQSGRSSLTPKSAIPGVSVGAEGSFAQPIRAPGAHHEKSHSGQWIQTPNSLSSFPGSGFSSPLQQGIQGNQINDLIMKGGISMPAKLGTPAANAAASQEARRKRRRESHNLVERRRRDNINERIQDLSKLVPPHRLEDEKIRKAIQNGTPLSPSLTGIGGSATSGLAGPGARRAAGGTAGNITTGLPVEEKDKGPNKGDILNGAVSWTRDLMWMLNLKLQQQEELINALYERGGTLPFEITDDERRMQTELAEAMNRIDEATGQPRTFTYSRTAGSGLRVPHHTDYKGDPLNGSGSNGNGGLSANGGQDHGSLSPGDRGMAHDMMDSNDFVDFDDDASLKEEDEFNMDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2I8</accession>
    <name>A0ABR3V2I8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000486">
        <property type="protein sequence ID" value="KAL1835992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="413" mass="45090" checksum="827E15A6B5793660" modified="2025-10-08" version="1">MSAPQAQQPQIQPCRYKVGKVLGAGSYSVVKECIHIDTGRYYAAKVINKRLMAGREHMVRNEIAVLKKVSMGHQNILTLVDYFETMNNLYLVTDLALGGELFDRICRKGSYYESDAADLIRAVLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFKKTGHGKPVDLWALGVITYFLLCGYTPFDRDSDFEEMQAILNADYSFTPIEYWRGVSDSAKDFIRRCLTIDPNKRMTAHEALQHPFVAGWAKVNAQGGAEGVDKGTNLLPTVKKNFNARRTLHAAIDTVRAINKLREGQGAGGLMNGVRSREPVREVAGGPGKGAANGEEGNKNGVRKDDSGVAMQTSTSDGSNGTAKSSGPGGCCTGKLEAGERGQQGRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2K9</accession>
    <name>A0ABR3V2K9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000491">
        <property type="protein sequence ID" value="KAL1835972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047522757" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="172" mass="17715" checksum="6905C9F24044C5E8" modified="2025-10-08" version="1">MLYSQLVAFLGLAGAALGQITLTPTTIRTGRPGLPTETVTATVTDTQTVTATVTKTETYLSQTTVISTSVRTVTSTRTSTSTRTSTATSTTTKTATVTAPCSTKSVNCPTLTRTQTACATCFIPQCTTTVAVTQSCGCAALPTATVAFPCNAPDSCNKIGCKTVYDIKTQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2U4</accession>
    <name>A0ABR3V2U4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000466">
        <property type="protein sequence ID" value="KAL1836093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="247" mass="24434" checksum="8F1DA6E51E11C571" modified="2025-10-08" version="1">MHTMPPNPAAADRSASTTDAAPTTTSKAAATTPTADMAPLSTLDVFILTFNCAKSLVNPTVFAAHLHGALAGQNGNGSSIALPDLVVFSLQEVAPLSYSFIGSYFLNPYYARFTEALNLASTWALGHGDAPTTAAASSSSPSSPDNSAAMARPSSDSPPYTLVRAKNVGMTAMLLYARDPTAVTAIAEAECGFGAADMGNKGAVGLRVTWKDGGGGGGGGGGAAAAAGVLVVVGTGGGSGVSMKTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2X4</accession>
    <name>A0ABR3V2X4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000461">
        <property type="protein sequence ID" value="KAL1836127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="41354" checksum="04B47A14220F9907" modified="2025-10-08" version="1">MTPPQSSHDLGSTMATTNTTSPGNPPSPQPRFTRQHSNREHTVAYADLMVSPDEDWRNLPNAAERRKIQNRLAQRAYRRSLRERNEEIKRLRKKVEELEEKGAQNELQTPPTEPDSNTAPSLTVSAATSTYADTVHSSASVTSASDWMGDYLGVWPHTPLSDHGSLTGSSNAMDTFGTDFNMDAPAADHMLQPISEPAGMDPSGTTAETVLPAAVVSPFAQFGKSGSTNTSNNGGHNMFSFHQPLTLGTGDFNLCTHRQQQRLSPAATPRLSPCGSSVHGATRHDTFHSYPTPPPSHYCGCSSSPSPSSASSVSNEHQHGRCVVRPLDAESLYLQGLVVEPCDGGDGVTIRLPGSGVGDGKATVVAFMIQRDGTAGNKNNGNNNTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V306</accession>
    <name>A0ABR3V306_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000526">
        <property type="protein sequence ID" value="KAL1835841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="551"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="658" mass="70616" checksum="4A16DDEA448C8C06" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V382</accession>
    <name>A0ABR3V382_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000450">
        <property type="protein sequence ID" value="KAL1836184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF18">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="41"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="308" mass="32811" checksum="7BD6B3328DA8120B" modified="2025-10-08" version="1">MTKNNATIIVTGQLSFGDRVALGVLTPVVGSTDENQVGPTVLYIHGGGYVNPLRGPAHMPFIMECATACGARNVVILEYGLAPEHPYPAQLVHCVAALRHLLQPTAPGMNLRPEDVVLAGDSAGGQLVGALLAHIAYPSPYAAPLQLDGQLRAALLVSPFVRLPPPGSGSYESNHGRDYLTRLQVNMFKAAWGAREDEVWANLCGAEGPGKVWSQVFGCGSSRLVRKVMVTVGTAEIFLDCCRTFSREHVQAEVIAANKDTEFSVFEGQDAVFVECEGEVHVQPALDTAVGYDGGVMKRAIMSWLGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3D4</accession>
    <name>A0ABR3V3D4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000515">
        <property type="protein sequence ID" value="KAL1835891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="223" mass="24255" checksum="624B5C2B2DD17F94" modified="2025-10-08" version="1">MDLMNPGESRRRMLAGELYYAFAPDLTEDRRRCKVACHAYNTANASGAPRRTLVELWKEIVGDKTPLPPEGSPEEIEALRAYPWNDGPIKFDYGYNCKFGPGVYINSNCTFLDTCIITIGARTLIGPNCSFYAATHPVDPAVRNGVLGPEYGKPITVGEDCWFGGNVIVLPGVTIGRGVTIGAGSVVTKDVEDFVVVAGNPARVIKRLENTLDKKEDAEEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3F3</accession>
    <name>A0ABR3V3F3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000431">
        <property type="protein sequence ID" value="KAL1836307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="663" mass="72432" checksum="E3507B70539E130B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3N4</accession>
    <name>A0ABR3V3N4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000428">
        <property type="protein sequence ID" value="KAL1836331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="351" mass="38015" checksum="3BF4D0F9A55CD184" modified="2025-10-08" version="1">MESSPFSTPKRKHSEMLSDSHLQLEPTTQFTFTVKSALDDRGVSPWTRVTHKFRDLALGSGGGGSGSSADPGSTDLAEESPRKRLKLPEVEMVDAENVAAQPSTSISTSPLQSGVAQCDKGRCPKRRSPTRTVSFALDEAVVEQTETMANTKVNLDESGESVDKNETDRNNHDATPSITTSNLPSTTSKSQPCKSSFKRSGTPPFESAHKPPGGSKSTTPSPTIVDPVRAALTWREEEITIYDPDDSDDDGTGINGIGFKPTPAIAYARALRRRQQLDEYRRREEREARAKRNMLRRRGGSPASVGSVDSVVKAKAKNDRRRVRFLEGVVERAMEGGGVVKMTVVGGEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V419</accession>
    <name>A0ABR3V419_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leptomycin B resistance protein pmd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000450">
        <property type="protein sequence ID" value="KAL1836186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="881"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="962"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="62"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="394"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="717"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1836186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1293" mass="140536" checksum="B7E6D4B0C774F2F7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4C1</accession>
    <name>A0ABR3V4C1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000388">
        <property type="protein sequence ID" value="KAL1836622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="297"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1532"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="902"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="945"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1532"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1565" mass="171293" checksum="2C3108146A905F50" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4I5</accession>
    <name>A0ABR3V4I5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000378">
        <property type="protein sequence ID" value="KAL1836692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="331" mass="34978" checksum="5694F7BA020D473B" modified="2025-10-08" version="1">MYPLVTSDGYKYPGDETYVLDILPVATGLAATASDQTLSLFDPLRLSQGPVRKITTDHGNLKAAKVYSGVNSIICTAGENGTVSVWDLRLNPSNARALQIGGNLPGLLALSCSEESNTLAAGTELANHQASILIWDLRSPSTPKSQYHEVHSDDVTELSFHPSTPHLLLSGSTDGLVNVTDTRITDEDEAVQATFNHGSVHRAGFLTSEIVTNDDPSSLLLYAASHDEKFAIYDAAEGSGSGAPTLDLGDVREALGCQYLAGVLAKVDGNGAVVGVGAQESDGWGLDRDMVVGLPGAHGSELVRSFCFYDEQRVVFTAGEDGCVKAWRPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4I9</accession>
    <name>A0ABR3V4I9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000449">
        <property type="protein sequence ID" value="KAL1836193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="305" mass="34956" checksum="430E6D6B780AE9D0" modified="2025-10-08" version="1">MDAFVDKPKPLAAVRRESLGPAYEVRPVPGKGQGVVATRRIRAGEIVMVDVPAVLIQIAFLADTKPHHRRRILKQAINQLPEETRNKVYQLHRGSAKYEIDAILGPNSNTVMLAETEVHVGVFPEVARINHSCRPKFSERRLTMEIVAYREIKPGEEILISYVPLETPVEQRKRYLKENWGFECTCSLCRGSEEELENSESWRRKTKSLKETIADAKSTGYYKDAIVMTEELLMFSEWDRVPPFMPDYHDTLAHLYYLNGNMANATRYARMAMDGWVKFGSVDDEDLEKARVFLEHLARLNEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4L7</accession>
    <name>A0ABR3V4L7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000378">
        <property type="protein sequence ID" value="KAL1836690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="132"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="960" mass="107313" checksum="17CD5B7326629F3D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4P6</accession>
    <name>A0ABR3V4P6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000372">
        <property type="protein sequence ID" value="KAL1836734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="929" mass="103468" checksum="1365922F907D5FE3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4T3</accession>
    <name>A0ABR3V4T3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000369">
        <property type="protein sequence ID" value="KAL1836760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1836760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="467" mass="52006" checksum="9B472B4CA7F61690" modified="2025-10-08" version="1">MDYDTILKGKYPAKQHARRVVDYIRNKVPGASGVIYLESRMSKLIEDSDEPEPFRQRRYFFYLTGCKLADSYVIHDLDTARTTLFIPPIDPDSVMWAGLPMSPDEALAKYDVDEVKFTTDLNAELAHLSSSAVPRPNPATVFAIPGQVSEQVTFLGFDSTNFSVLKEAIETCRVVKDEYELALIAKANAITAEGHHAVMKHVRTASNERELEGVFTGHCISSGAKEQAYPGIFAAGRSCATLHYVHNDAPLEGKLNLLLDAGAEWDCYASDVTRTFPINGRFTPESRAIYDIVLRMQEECIKALKAGVVWDDIHLLAHRVAIEGLLKIGILRGGDVDAILERRTSVAFLPHGLGHYLGMDTHDTGGNPNYADKDLMFRYLRIRGKVPAGSVVTVEPGIYFSRFIIEPYLKDPKHAEFIDAEVLEKYWDVGGVRIEDNVVVTEDGHINLTTTVKDPEEMERIIQSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V537</accession>
    <name>A0ABR3V537_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000361">
        <property type="protein sequence ID" value="KAL1836826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="89" mass="9433" checksum="C24613F376A862A0" modified="2025-10-08" version="1">MNAAASPIAIPAPSPRRTPNMMGLSRLVTAQEELFASLNATLAKNNINGQLDLSTPVRHIPENDYTVPAPPPPSPVGFREHCGCETDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5E0</accession>
    <name>A0ABR3V5E0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_4433</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000344">
        <property type="protein sequence ID" value="KAL1836969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046464761" description="RING-type E3 ubiquitin transferase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="268"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="433"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="513"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="516"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1836969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="593" mass="63487" checksum="BD2743A07DEA6A1E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5E9</accession>
    <name>A0ABR3V5E9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000385">
        <property type="protein sequence ID" value="KAL1836641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="11"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="922" mass="102000" checksum="4598FEB7AAAAE0B8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Q5</accession>
    <name>A0ABR3V5Q5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000353">
        <property type="protein sequence ID" value="KAL1836897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28815" checksum="2988086949C1ED05" modified="2025-10-08" version="1">MGWFWSSSPPSKPEGSSPTPTPPPSSSTPNQAPPSTKSESSADQEVAMFMQMLMKDTNSSSTSQSQTTTTPPQPPSSPSSPSSSWTSSLPWPFKSTPETPPTTTSTPPIPPRDRSPQSLAMSEHSLPTTMSCRDAFDYAWHCHTPGAQWNAVYRYGSVRPCTELWDDFWFCMRTRTYPPEARAEAIKEHYRAKEARKYGGGKPSSEDVWESRDERVAPGTAFKQTFEPPIVDDEEFRREDLERRRRVRETEGLSDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V642</accession>
    <name>A0ABR3V642_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4343</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000336">
        <property type="protein sequence ID" value="KAL1837032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="193"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1837032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="641" mass="69201" checksum="DD92A1AE689508ED" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V645</accession>
    <name>A0ABR3V645_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000349">
        <property type="protein sequence ID" value="KAL1836921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF2">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="320" mass="35857" checksum="4D0CD210FF5BD741" modified="2025-10-08" version="1">MPSSSSKSKPKPSEVASEAKRYYIPLIREKYSSTWATCSYLYEQPLDQITFTDRPLDLSPPTFYVRTGDPVNTALEWAQSVGTSIPFICAANDKRPGGDWETGVVGYEERLCRRSTLAACLATPADGSPANAYYPLQICAGILSPQVVVFRGPHDRYEKLPIDQWRELPVISVPPPRWPKLTQNGTKYSFGDEREMVKDKMRGALRICAYNGYSTVVIGDFGLGNGYRNPPQELAELWREVCLYDPDLRGRIRCVTFVLEDPNQSTAQLILDDIAKKAKGSSSGSSSSNFEIFSRVFDPVEIQRFLAQPDARYGWNTLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6J5</accession>
    <name>A0ABR3V6J5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein ypt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000300">
        <property type="protein sequence ID" value="KAL1837384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35535" checksum="7CEB72B24D855FC9" modified="2025-10-08" version="1">MSYELPGMTRPRRSSATSDDSTATVREQELGSMYDYLAKIILLGPSGTGKSCLLHRFVKNEWRVLSSQTIGVEFATKIIKVGTGARRKRIKLQLWDTAGTERFRSVSRSYYRGAAGAILVYDVTSHMSFRALQPFLNDARALASPNLSIVLVGNKLDLAHDALVDTGLPPPTPGSASLASTPIPSSYSSTSTIHPGFGAQLKATVAPDGREVAASEAARWASTVQIPVTMEVSAFSGEGVDEVFGRLARMILTKIELGEIDPDDPMSGIQYGDGGAMWNAGASDGGSIKSGMTADDGGGRRRRRGRRGGQGLREWEEVFTLTSRRRNAGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6S6</accession>
    <name>A0ABR3V6S6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000291">
        <property type="protein sequence ID" value="KAL1837473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045405795" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="99" mass="10680" checksum="2FFF1EBF36BE1DA4" modified="2025-10-08" version="1">MQLTKSLILAFTLLTSGVLAAPAETTAVAVSDSANAPAAVSPNAISEYACWRDCRTQCNFRPTAPDGRCDGFCIYNCMIRYCPESRRVRMEPGPSKSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6T8</accession>
    <name>A0ABR3V6T8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000325">
        <property type="protein sequence ID" value="KAL1837136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="167"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="448" mass="50740" checksum="75B1C0AF819D56F0" modified="2025-10-08" version="1">MASAIFFLDLKGKTLLARNYRGDIPMSAVEQFPILLNEAEEESSAVPPCFSHEGINYLYIRHNNLYLLALTKRNTNAAEILLFLHKIVEVFTEYFKVLEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEIQARPPIAVTNAVSWRSEGIRYRKNEVFLDVIESLNLLVSANGNVLRSEILGAIKMKCYLSGMPELRLGLNDKVMFETTGRTTRGKAIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECVVESHSGSRIEYMLKARAQFKRRSTANNVEIIVPVPDDADTPRFRTNVGSVHYAPEQSAIVWKIKQFGGGKEFLMRAELGLPSVRGDDEHGGGMMGGFGGSMGGIAGAGKGAKRPIQVKFEIPYFTTSGIQVRYLKITEPKLQYPSLPWVRYITQSGDIAVRLPDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7C0</accession>
    <name>A0ABR3V7C0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000303">
        <property type="protein sequence ID" value="KAL1837356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7C4</accession>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Schmutz J."/>
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                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="EMBL" id="KAL1837595.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="163" mass="17851" checksum="7D5301D36CFCD2C8" modified="2025-10-08" version="1">MMDGPSSRLPAAPPKAKAVDDLQISLRLRYGVHVIFIIAMLDWTFEQLTTELLSILRDRYPEGLRREPPLPSLPGLPTAPSSEETTPIPAEGADVRVAYALPQNPNDFSAGWKNLKAQPGDTLKKKGIKDWSSLAFVFVDADESDADTEFHVVVPSVPEESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7N0</accession>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Clum A."/>
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                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="Proteomes" id="UP001583172">
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    </dbReference>
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        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="461" mass="52334" checksum="7FE7293BA6E8287C" modified="2025-10-08" version="1">MSTSTLLPFLYQTRTLQRLARTGAFRALLHSTAAPRDARDRPHVKPLKTRYEDNSYIPFQLPEGYVQDKGDEDAESNSTLTPAEKDVFNRIFEEIATRRGVKSAVWPPPAEPPASAPEDEDAAPAQLPLPNLDNAEVFGVRTEEPQHKLVQNTFNFIIQDITEPRRAKKAGRAPELQEEPAVSSEWDYALQRFPPSLRRAAKLALSTIHEEKPAERQSIADAITAVKRINRKPKDSDELLRKHQKPSTTSVLNEAIRREERIRVEAKMEAARSDFELWDVLEEEVFSLVHKLGIDAVPDKTTESTEKTKKLPLDAYGPLYPAYLLTALRLLDTHFARTSPLALQILPRVKQLGAASYVLGVTTPFYNQLAHIMWNRYGDPAAVFDLLEEMRAAGLYCDETTRKLVLSIQQFFQAVGQGQWGPFVREVASLPEFELTLMPRVRHWIKTANVHIYERKRGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7W6</accession>
    <name>A0ABR3V7W6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000253">
        <property type="protein sequence ID" value="KAL1837900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1336"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1513"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1656"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1974"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="10">
        <location>
            <begin position="2637"/>
            <end position="2780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2785"/>
            <end position="2826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2785"/>
            <end position="2812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2826" mass="306786" checksum="CD9DFAC1DC2C0395" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V872</accession>
    <name>A0ABR3V872_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LRR-containing protein second PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000244">
        <property type="protein sequence ID" value="KAL1838019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRR-containing protein second PH" evidence="3">
        <location>
            <begin position="224"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="955"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1083" mass="120163" checksum="616EFC6029EE0A63" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8B7</accession>
    <name>A0ABR3V8B7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000247">
        <property type="protein sequence ID" value="KAL1837981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="600"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="900" mass="101339" checksum="C320E67E5C14AECD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8H5</accession>
    <name>A0ABR3V8H5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">VTJ49DRAFT_3235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000250">
        <property type="protein sequence ID" value="KAL1837940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="1444"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="1444"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="621"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1113"/>
        </location>
    </feature>
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        <location>
            <begin position="1226"/>
            <end position="1251"/>
        </location>
    </feature>
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        <location>
            <begin position="1336"/>
            <end position="1441"/>
        </location>
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        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
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            <end position="505"/>
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        <location>
            <begin position="1395"/>
            <end position="1439"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1469" mass="159846" checksum="75D40E9ECB5A57D1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8T2</accession>
    <name>A0ABR3V8T2_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">DUF1989 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">VTJ49DRAFT_3010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="308" mass="34134" checksum="34A0A27A92BD3D21" modified="2025-10-08" version="1">MSTTDTDGGATIGPRTRKPVPPPVPAYLPTAGSPLTVSPALYTLIQQAPRIKTTEFTLPIRSGRAWTVPAGGIVRISTPHGPQVGDLNLWNAHNPRERFWASRTRQLHATHVSTYDRLWSCLPYMRPMATIIADTLSWYGEDEHGGRIHDLLGTRCDPYIRAVLSGGTSYDFHCHSNLTRAILPYGLAEPDVHDVINLFQVTGLDDSGRYFMSPCPAERGDYIEFFAEQDLLMALSTCPGGDLSLWGFGANKDKEMMECCRPLSVEVFKLADEDFLRRVGWRPTETSPYRGLHGMAVVEGEKAAEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8U8</accession>
    <name>A0ABR3V8U8_HUMIN</name>
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        </alternativeName>
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    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
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                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
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        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
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        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="229"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="571" mass="64301" checksum="5136551E95573791" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V996</accession>
    <name>A0ABR3V996_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_3232</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000249">
        <property type="protein sequence ID" value="KAL1837961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1837961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="550" mass="62592" checksum="30BD9D324C60F1B1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9F0</accession>
    <name>A0ABR3V9F0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000213">
        <property type="protein sequence ID" value="KAL1838455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40060" checksum="957E28055D082458" modified="2025-10-08" version="1">MPGPGQKHRTGPATMGIPNIPAHYRRRAAHPGLLACLAALGLIGLFFARDLLYDTWTLAAMPLLWPRHGHLFHLSAPGSGFDVTFSNYSVDQTSAAAQGYEDRVPAVLHHISLGDGAAVHARWMEVRQTCLDMHPGWQAYLWTDETADQLVRERFPGVYEMWKGYRYPIQRIDALRYMVLYHYGGVILDMDLQCKRSFGPLRRYEFVAPEAHPAGFSIGFMMAARENPFVGELVRNLPRYNRRWLGLPYPTVMFSTGCHYASTIHTLQPAHLRAKLKILSGPKTNPNMHRLNGPVSTPLFNHLGSSSWHAYDAAMIVALGKSAAARTWVLPVVGISAVGVAFCVVRRVRRRRRVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9K7</accession>
    <name>A0ABR3V9K7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000216">
        <property type="protein sequence ID" value="KAL1838401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="5">
        <location>
            <begin position="112"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="346"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="845"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1174"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1435"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1503" mass="167577" checksum="0CF688A982261660" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9T2</accession>
    <name>A0ABR3V9T2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial outer membrane protein porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000212">
        <property type="protein sequence ID" value="KAL1838476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="29964" checksum="D0FC4FE99C2A2630" modified="2025-10-08" version="1">MGVPAFSDIAKAANDLLNKDFYHLSAGTIEVKSNTPNNVAFKVTGKSTHDKATSGTIEGKYSDKPNGLTLTQTWNTANTLETKVEMADNIAKGLKAEGIFSFLPATQAYGTKFNLHFQQSNFNGRAFFDLLKGPTASIDAIVGRDGFLAGASAGYDVAKAKITGYSAAIGYHAPTYSAAITATDNLSVFAASYYHKVNSQVEAGSKATWNSKSGNAVGLEVAAKYRLDPVSFVKAKINDRGVAAVAYNVLLREGVTLGVGASFDTQKLDQATHKVGTSFTFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA32</accession>
    <name>A0ABR3VA32_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000211">
        <property type="protein sequence ID" value="KAL1838480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="272" mass="30069" checksum="DEE8D1A051C7508E" modified="2025-10-08" version="1">MSGDPWNLSLDDLLNTETPEQHAAAIARKLGENASKADFIPSPWAGEIIQLKFANNVTYPISSGLLSKCPSLAALVKNGIADLTLHSPTAGHALVHLLHLNEYSPMRPTGVDHTYQTPHDITLGTVETGVIKIYDDPKGIAALKSVLDTCYLARVLQYEALENAAFEDLAVGLWALGPTGLETTIKATFPRPLSEDPVFEAELKKFVGDWDVKGPWRVKPVMGGPPLWLWFVFEGRPKDWEFAVGYQDYAKTLREAYINAKSRYYWSGGKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAC8</accession>
    <name>A0ABR3VAC8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000217">
        <property type="protein sequence ID" value="KAL1838391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="132" mass="14930" checksum="FE7761C32FEBBD4A" modified="2025-10-08" version="1">MPSIMQRTRLLLKEQRDSTAVRAAQICADLQTSRGHLAELEKDNLALCRQNIELAEEVLDLAGKAHPPKQTTFTKSRFENELTKLEREVASGRRRWKVVKGATSAIVAGSSMDWVRDERLKNLVLDSADDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAY7</accession>
    <name>A0ABR3VAY7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000180">
        <property type="protein sequence ID" value="KAL1839004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="260" mass="27799" checksum="5BF7232C93D23230" modified="2025-10-08" version="1">MIVVDNSESSRNGDYAPTRFDAQADAVGIIFQNVVQGNPESSVGLMSMGGKGPEVLATLTTDQGKILEGLHQTKKKIRGSAHLSTGIQIASLALKHRQNKSQKARIIVFVCSPIEEGERELVTLAKKMKKFSISVDFVLFGDIDAANEAKLQAFNREIKGNTDSSHLVIIPPSSKLLSDQLISTPILLGEGGASGLGGLGAEGGANEDFPFGVDPSQDPELALALRMSMEEEKARQEKLAREQAEAAKKANLESVKEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBF8</accession>
    <name>A0ABR3VBF8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tuberous sclerosis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000178">
        <property type="protein sequence ID" value="KAL1839053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="662"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="939" mass="105130" checksum="64F240AEF7D43C9C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBU5</accession>
    <name>A0ABR3VBU5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_1647</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000164">
        <property type="protein sequence ID" value="KAL1839319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="232"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="236"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="475"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="532" mass="59301" checksum="E9A6A6B1B1C0AD8F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC30</accession>
    <name>A0ABR3VC30_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000167">
        <property type="protein sequence ID" value="KAL1839254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="293" mass="34319" checksum="2CCCA87563EDEA34" modified="2025-10-08" version="1">MTNIEQEVAELKKQVQVLQKELSRVSDEAEIRKIHHKYGYYLDKCLYNEVVDMFADHPDAYVEFLGSRYRGKAGIKRLYQGRFQQMFVKGRNGPVYGWLLDHIMMQDIVDVDHTGTHAWCRMRALMQAGTHQSIEEYYPRGHRQWWEGGLYENEYIKEDGVWKLFRYRYFPFWHAEFERGWSHTKKNYIPFPTVTYPEDPLGPDELIDQKMLWPDTRVVPFHYPHPVTGKATAPDDLRAPVYGQDVSTSEPPLTLALPEGQIRPGASTREPRKEDKVLPELVQNKVESTENGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC70</accession>
    <name>A0ABR3VC70_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate synthase</fullName>
            <ecNumber evidence="4">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_2021</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000182">
        <property type="protein sequence ID" value="KAL1838976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="586"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="814"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1838976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="917" mass="103623" checksum="0EAED2368101A90A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC92</accession>
    <name>A0ABR3VC92_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000181">
        <property type="protein sequence ID" value="KAL1838996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="14"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="359" mass="37789" checksum="5569FB993F9C852A" modified="2025-10-08" version="1">MGSLSPDPPKPWVETPLIFSPPLSRIAGCNIYLKLENVQPSGSFKSRGIGNMMYKSIFSSSGPTPSPSDVHFFCSSGGNAGLACATTASVLRRPATIVVPLSTSAFMVSKLRELGAEVIQTGASWVEADTFLRETLLRPDPRVKKVYVPPFDHPDVWAGAATLVDELAADVAQGRLGTGSGRVDGVVCNVGGGGLLNGVMEGLERNAKLLGGGPKVLAVETVGADSLSASVKAGELVTLPAITSVATSLGARRVSEKTWEWWVRKGVTEERKEGTLISATVTDRDAAAACVRFLDDARLLVEVACGATLATVYNGGLRKHLGAGLTDEEWATRNVVLVVCGGSNVSWEILEKYKATYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCC3</accession>
    <name>A0ABR3VCC3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="69962" checksum="13E1A75E5E99D134" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCI1</accession>
    <name>A0ABR3VCI1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000160">
        <property type="protein sequence ID" value="KAL1839383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15998" checksum="1A9324F11BF20C0E" modified="2025-10-08" version="1">MSLKEEFATRNFSIYGQWLGILSMILCFALGIANIFTFRVVIMVFSGLCLASSFVILFVEVPLLLRICPTSSTFDAFIRRITTNYMRAAAYLVMALLQWLSLLGGASSLIAAAVFLTATACCYLLAGVKGQAFVGSKTLGGAGVAQMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCL2</accession>
    <name>A0ABR3VCL2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000149">
        <property type="protein sequence ID" value="KAL1839589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22922" checksum="58198E05B46528E2" modified="2025-10-08" version="1">MLFGIFFVFWRFFEIITLVPIVGMLGYSVDIYLNNNVMTPASVLVLFIVSVLALVWAILTLFSYHRSKAHANFVAIIDLAFVGAFIAGVYYMRFITRADCTSIQRGSQVDRQFGILGISGSIRFDTFEVNVNKTCAMFKASFAFGIINCILFFCTALLACIYGDRSAKERRRYEERRSSRHRSHSGHRSHRSSHSHSRAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCY3</accession>
    <name>A0ABR3VCY3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="272" mass="29268" checksum="AB8471BAC02828AE" modified="2025-10-08" version="1">MEPLPAATPSVATLCGWALVVCLLIVNIKGLPFVHSIRLLPSLYRLLRPRLFSSPMKGSTSKPTADSTPAAAADAPLSARPRLFQHHITHSRAVLSDLDVNIHKSNSTFFADADINRAELLTRWLSRGLVGCVPILAAVQCTFVREIGPFKAYDLSSRILCWDEKSLFMVTYFLKPRTTLPSDVELAGGPAAVLQDWSLRRCVYAVLVTRYVCKGKARKTFAPAAVLATAGLLVSGVGTPGEKESGGGQLLTADIVEKAVKSGMEYVGGCMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDB3</accession>
    <name>A0ABR3VDB3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1030"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="929"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1224" mass="135159" checksum="49CFD4F2D5136B4C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDR6</accession>
    <name>A0ABR3VDR6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="191" mass="22696" checksum="97D18613970B82E4" modified="2025-10-08" version="1">MWFARWGREHENPNNLYLVKIYARDYYYKFLGELQKIWYAPLFRVHPPPEIAEILWLIHCINRVPEKSKYFSQIDNKHLTDGQTMKCQASLDQQVARYFGISKPHTLFSRHKNMSGMDFLPKGSRFNEMVLTPNVMEALFVGEMIPLPKAEALWNSKQLSILDYHCRIREWNIKLVDATIADFQKHGERYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDW8</accession>
    <name>A0ABR3VDW8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="9" type="ORF">VTJ49DRAFT_966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000133">
        <property type="protein sequence ID" value="KAL1839961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="230" mass="25806" checksum="55D3CB8EFA555232" modified="2025-10-08" version="1">MVYSEPGEDCKRSARPAGDVDGSVGWWQWEASSSKSNEGFASFNGMYSFLSSALRVNQAGELAATLIYTHQTPPILAREPHLRPLMQHMYDQEASHLQTFNTLLAKHRVRPSALYPVWSALATGLGWATGVMSREAAMACTEAVETEIGDHYNAQIRQLLEMVAGWEAEGYEVGQEFRELIETLRRIRDEELEHLDHAVEHDAKKAEPHWLLTGVIRAGCRGAIWVSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE50</accession>
    <name>A0ABR3VE50_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000126">
        <property type="protein sequence ID" value="KAL1840119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="82" mass="9386" checksum="8A0407652A178884" modified="2025-10-08" version="1">MGRTYPKNPSTTSRTPIQWTDQVAHKYCGKIDLGRIGRPNKAHRCDACLAIKHRESRYRDGPKNIKAGRLEKMAWLTGDAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEC7</accession>
    <name>A0ABR3VEC7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin interaction domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000155">
        <property type="protein sequence ID" value="KAL1839476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="886"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="103171" checksum="B1B93B52BA067A01" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEW5</accession>
    <name>A0ABR3VEW5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000117">
        <property type="protein sequence ID" value="KAL1840342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="242" mass="27348" checksum="F3DAE55D23E4FDC6" modified="2025-10-08" version="1">MESNRRRAASIERQAASIEWRAARLQEKEARIKDQEPTRIQQWGAIGRERSAIEEQRDANRSEWRVIDKERKACDAEHRAVWAQRDARNQERLAVQEQRELVRNQQADMSAQRAMSVPPERPSSEYKAARDEYHTAAMDFYAACRDYSAAREELSAASREFVQASMKYVASSKECHRATMDYYAAGKEYHEAFMAFLEPSRACQQLSPPKGTYGAGASETGEETSAMGCPDAPTPASSASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFD6</accession>
    <name>A0ABR3VFD6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="12"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="365" mass="39576" checksum="265AB1983A13D353" modified="2025-10-08" version="1">MTTMKEALVRKGVHVSIVDTPIPTINDDQVLIRVVVSGSNPKDWKIPEWLGTEDSPGTNEGDDIAGIVEKVGSRVFEFKPGDRVAAFHEMRTRGGSYAEYAVAWQHTTFHIPKETSFEAALPLAAMTSAVGLYQRLRLPQPWDPPTTPAPGPLVIYGASSAVGIYALQLALRSGIHPLITVAGRAKDYVSSFLDPAKGDVIIDYRDGDEAVVKGLVDVLQKYRQQHGPGPVYVLDAVSEGSSITNVAAALHQVLGSDNTTSASKVTFVLHTAEPKAAEVFPASVERSITMVGDVHKDAKDFGYVYFRYFARGLQEGWFKPQRTEVVPGGLGGIETALRNLKEGKASAVKYVFRIAETEGVQGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFT2</accession>
    <name>A0ABR3VFT2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-nitropropane dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000116">
        <property type="protein sequence ID" value="KAL1840362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="36903" checksum="52699AEC112B40EB" modified="2025-10-08" version="1">MSSSGPITTPLTTLLGIRHPILLAGMARTSNGRLAAAVSNAGGLGVVGGFMYTPDQLREILADLKANLRDPSLPFGVDLALPQVGGNARKTNHDYTGGKLDELIDITIESGAKLFVSAVGVPPKRIIDKLHAAGILVMNMVGHPKHAVKALDLGVDMVCAQGGEGGGHTGDLAGTVLIPAVVDVARRYRPAMLGGKQHALVVAAGGIHNGRGLAAALMQGAAGVWVGTRFVASVEAGCSEQHKQEVVSCGFEGTETTLVLSGRPLRMKTNDYIRKWHAQPDKIRELCSKGVVPLEHDLEQGNEVDPPHLMGQVAGAIQKIQPAGEIVDEMVAEAVDMLKLASVYLGGNQGGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFW0</accession>
    <name>A0ABR3VFW0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="71145" checksum="D22A48C897316731" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGH2</accession>
    <name>A0ABR3VGH2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_7618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000094">
        <property type="protein sequence ID" value="KAL1840920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045439053" description="Methylated-DNA--protein-cysteine methyltransferase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="14">
        <location>
            <begin position="127"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1840920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="233" mass="25705" checksum="4611532F6C6AA23D" modified="2025-10-08" version="1">MVVIKGRELSFVAIDLLVVALATMANGSRDTPQHRFGYRRPDCERVHRSRPGEVSRLWVSDSGWDRRPREPSAPVHAPRLVEQFSDTVHATTTTTTKTTTTKTKPIPRDLTKIPLAPPLLTSPRGTPFERAVWSLTYQIPPGCFSTYALLAAHLGSSPRAVGNALRRNPFAPEVPCHRVVATDQTLGGFKGKIARRDGEGITLAEKRTLLRKEGVRFDATGTRVLGTAFRGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH20</accession>
    <name>A0ABR3VH20_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="360" mass="40284" checksum="0BE25A01562F6F6B" modified="2025-10-08" version="1">MVDAQKDAPFKSAQVESLVVMKIVKHCSSAFPTTATGSLVGMDTDGVLEITNAFPFPTLDVSAADGHQADASSFAAAAPRAKANIAYQNEMIRHLKEVNVDANNVGWYTSATMGNFINLSFIENQYHYQRENDKTVALVHDVSRSSQGALSLRAFRLSPEFMAAYKEGKFTTESLQKSKLSFHDILVEVPVIVHNSHLLTSFLHQIPAPPESAEIPLPASLDDIRREPAPLPAHPYFDTLDVSIDPFLEKTCDLLLESIEAHYSDLNNHQYYQRQLAREQFKISQWQAKRKAENAARLAAKQEPLPEDEWQRLFKLPQEPSRLEGMLNARQVEQYSKQVDGFTATVTSKLFAVRGNLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHC8</accession>
    <name>A0ABR3VHC8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_7409</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1127"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1207"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1246"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="15">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="261"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1286"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1841078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1332" mass="148704" checksum="EF62913D93B303C7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHU5</accession>
    <name>A0ABR3VHU5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="37"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="90" mass="9987" checksum="6A125FD01F9D1226" modified="2025-10-08" version="1">MGSFPALKLLSIDYAIDGRIPQEWTGLGTEQRVESLISRSAAETISHTYKQVVYLWIDALCIDQSNSTQEKATQIPLIGETYSLAARVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIN8</accession>
    <name>A0ABR3VIN8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="103"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="415" mass="46436" checksum="2548740774ED39FB" modified="2025-10-08" version="1">MAATTTTTTTTTRRGRKASISATGAAPAPIPQNVKAQQPSSGSGPEYPDIQTIRDAIPAHCFEPSTLRSLGYVVRDVAMASALGWAALTYVPSIENPLLRTAAWIVYGYVQGLICTGIWILAHEAGHGAFSVHRNLNDVVGWALHSALLVPYFSWKFSHHRHHRFTGHMEKDMAFVPHTAADRKKRRLADLYLDRELFEDVPVVQLFKLLAHQLAGWQAYLLFNVSAGSKSKQREGSWWRVSHFEPTSAVFRPSEAVYIALSDLGLALVSGVLYWASTILGWKTVFLLYGVPYFWVHHWLVAITYLHHTHPEVPHFEADSWTFVKGALATVDRDFGFVGRHLFHGIIDTHVVHHLFPRIPFYKAEEATEAIKPLLGDLYRCEKGSFIGSLWKTFTKCKYVEADPAVPGALKWAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ15</accession>
    <name>A0ABR3VJ15_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="306"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="494"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="610" mass="68475" checksum="BB91089B127CC26B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJM2</accession>
    <name>A0ABR3VJM2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000064">
        <property type="protein sequence ID" value="KAL1841787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="354" mass="39355" checksum="77DAE1A4750A9557" modified="2025-10-08" version="1">MASKFWPRAGNPGILHHFTETLVTFEFTTGTRPQPNSILFIGGLGDGLATTSYLADVVTALQPTSWSLFSPTLSSAYTAWGFSHLDRDTDEIASCIRHIQDYKAAKYGSPGRIVLMGHSTGSQCVLHYLSRPNPHTSTPSFDKGLEHVLRPKLDGAIMQAPVSDREALKWVVKEGFLGRTPEEMKESFDELVRLAREGLKNEDPTADCMLPIPLTRQFGYPGNTPISCRRWLSLASPDSPRSPGEDDMFSSDLGDEQIARTWGMVGPRGLLGFKLMVLMSGRDQAVPGWVDKEKLLARWRDAADRGGAYKVWDRERSGLIPNASHALSDDDQAEPRQFLCRRILDYLDELESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJS0</accession>
    <name>A0ABR3VJS0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4 6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="354"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="543" mass="59751" checksum="E5CD3044E60C72A0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJT9</accession>
    <name>A0ABR3VJT9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5942</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="352"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="582"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="829"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="489"/>
            <end position="501"/>
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    </feature>
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        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2043" mass="221352" checksum="EA216EAD158999AC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK49</accession>
    <name>A0ABR3VK49_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046663489" evidence="1">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="215" mass="23063" checksum="8DEB6E11CFEB5E79" modified="2025-10-08" version="1">MKFQLIAATAALLAASVAALPAAPQNDIRSLDVVDNGSFADILETRAPQDDLDDDDDFFSLTPDADFALEHLFAELEEIPDEVLEAGDEALNLWLIEHGYRSNDTAKRDVDAPANVFDAGGDGETGLVERGELEARKSTLGCIYAIGKLLVTTAVPAARILRIKKYIKALGGTKKAVKLLLKATSKKERLRIGGQALVDLAKELLGISAVKKACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKE0</accession>
    <name>A0ABR3VKE0_HUMIN</name>
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        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5718</name>
    </gene>
    <organism evidence="10 11">
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        <name type="common">Soft-rot fungus</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="35"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="850"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="739"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="906" mass="97245" checksum="15A7D00757652445" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKL5</accession>
    <name>A0ABR3VKL5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045359525" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="318" mass="35706" checksum="7794FD7EAB6FF920" modified="2025-10-08" version="1">MNILRLLSLLPSLTVLAHNHPPTTTTGTILTTDNIHLNYTQSGPLHGRNIVFIPGWRQTASEWQKQATYFSQSGFRVTTYDMRGHGDSDKPSFGYRLSRFAADLNDLLDQLKLTDVAIVGHSMGCSVAWAWWDQYNLVTKPKPGKHGHGNSPRRVVSSLMLVDQPAVMVRNPAWSDEYAARVGAIFEPQGIYDMANDIGAQLPSMLRGMFTTEVTEEEYQWVLAQNLKMSDENGAALLIDHGLADWRDVLPRIDVPTLVIAGDVSVFPVEGVRWVAEQIPGAEEYTFGQEERGSHFMFWENPERFNEVVKDFLTRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKU6</accession>
    <name>A0ABR3VKU6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="148" mass="16426" checksum="E18C3768E7E7D666" modified="2025-10-08" version="1">MSFGDAIRALLDTYANCISRLKAFKGGGNGSGAAPSHNDPSRLRKSLRRDRSLIEQTYSSRLSESGSRLNKGDARAVRALDRVLKRLRNAIANVLRLSTKGDGVDLDYNSLMALSNASRIDAIRTIDSLSHQVKERRFFGGLFSRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL34</accession>
    <name>A0ABR3VL34_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyruvate carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="536"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="67806" checksum="1D5D43AA0C8203E9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLE6</accession>
    <name>A0ABR3VLE6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="375" mass="41157" checksum="314C7A937713D9AB" modified="2025-10-08" version="1">MATDETKPARSRVFFDITIGGQPAGRIIFELYNDIVPKTAENFRALCTGEKGIGKAGKPLHYKGSIFHRVIKQFMIQGGDFTAANGTGGESIYGDKFEDENFQLKHDRPFLLSMANAGPGTNGSQFFITTVATPHLDGKHVVFGEVLSGKSVVRKIENLRTQADKPIKDAVIADCGELSPEEAVAADTKQADAYGDEYEDYPEDQVTGEDQELSAQEILKIASACKEFGNKAFKAGDYNVALDKYQKGLRYLNEDPDLNQEPPETKQQMDALRITLNSNSALMNLKLSDWNETVRSADNALAVNGISDKDKAKVLYRRGYAQVRLKDEDAALESLEQAKTLAPEDPAVISELNAVKKAAAARLAKEKAAYKKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM33</accession>
    <name>A0ABR3VM33_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="8"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="967"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2388"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="967"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1115"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2506"/>
            <end position="2530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="999"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2549" mass="279672" checksum="9F6EC32E9F47C51B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMM1</accession>
    <name>A0ABR3VMM1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="361" mass="41308" checksum="37D9B45C6CAE80BE" modified="2025-10-08" version="1">MVQSYITPGLRQSLEDTKVEYRRLGNSGLRVSVPIFGCMSFGDPRCLDWAITEEEALPLLKAAYDRGLNTWDTANIYSNGASEIIVGKALKKYNIPRDKVVIMTKCYWGVGDEPELRSVFLTEELKQSKDYVNHSGLSRTAIFNQVEASLKRLDTPYIDLLQIHRFDRDTPIEETMKALHDLVQSGKVRYIGASSMWATQFARMQFCAERNGWTKFISMQNHYNLLYREEEREMNRFCNDTGVGLIPWAPLCRGHLARRPEQFGSTTRSKGEKETQPGAHGTVEPDLTIIKRVVEIADKREWPISHVALAWINKRVTSPIIGFSKVERLDEAVAARGKVLTEEEEKYLEELYQPKPIYGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN27</accession>
    <name>A0ABR3VN27_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanine nucleotide-binding protein alpha-3 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="35132" checksum="51DC83C5B3C99FE3" modified="2025-10-08" version="1">MKIIHLKGYSREELTNFRPTVYKNLVECAKAVCAAMREFEIEPVLEQNRAYCDFLLEYELDQTDPYPVIDPKVGVAIQSVWSDPAKEQLMERQTEFYLMDSAEYFFQEAQRIVAPDYIPNESDVLRARIKTTGIYETRFKMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESSQNRMMESLLLFDSIVNSRWFVRTSIILFLNKVDIFKQKLTRSPLGNYFPDYQGGADVNKAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILNNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNB7</accession>
    <name>A0ABR3VNB7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_1971</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046421194" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1843384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="170" mass="16570" checksum="498B0B050AD08640" modified="2025-10-08" version="1">MKVLASLTTLALAGTAVAQGAPQLPPCAQDCATGFLDAGIGDCGRGDVKCICSNGEFLDQIACCLVGVCSSEDQTKAVEFALQLCRGFDVNDLPSSVTCATAAPSTDTTAAPTATDDDAAPTTDAPTTSAPTSADAAATTETSSNLGPRPTAAAAGLGAIGGIMAAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VND7</accession>
    <name>A0ABR3VND7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="478"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="685" mass="76007" checksum="CD7DBDE3E059B8F3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNK2</accession>
    <name>A0ABR3VNK2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_5012</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000040">
        <property type="protein sequence ID" value="KAL1842536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1842536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="216" mass="24995" checksum="3C2EEDE27EB9B84D" modified="2025-10-08" version="1">MTLYYTLVFMLLVAEMGLFLLLILPLPFAMRRKVFTFISENPIVAKVQYWLKITFVFILILFIDSVNRVYRVQLELAAASETTGPNVPTIHGHERLEVQARKFYSQRNMYLCGFTLFLSLILNRTYIMILEVLRLEERLKQYEGTGSTGSPTSGKKKPAGDLEAEVTRLRAELDRRDRDLDTLKKQAQGLHKEYDSLADKYESTQKASKDDSRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNR4</accession>
    <name>A0ABR3VNR4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF11">
        <property type="entry name" value="ZINC-CONTAINING ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="369" mass="38810" checksum="433DB263A226E625" modified="2025-10-08" version="1">MHRFLAPTLSRALRTTSRTTRSTSTTTAAATTLSSIRSSVLHNQQPNHSFHSCQALAMKAAKVTAWGSAPVYGDYPDLPDPSPSQVRVKVVAVAVPPVVRGRALGVHSTARGAPLPYDPTVDGVVQDEATGDLYYVSPMSSQLFAEYANVERHTLVRLAPGADPVAVATLVNPVGSSWMALRARALPGSVEGATVLVVGATSTSGRAAIAVARTLGAARIIGMSRNPETLEAVEGLDERVPLQEPFTLPESVGPVDIILDFVGGKTAVGVLCAAQPNPGKNLQYIHVGDLAGEETLPIPARLLNARPVLITGSGMGAWGKNEIKREIGGLLAAVSKMDRPEGVITAALSEIESVWDTEEAKKQRFVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPT7</accession>
    <name>A0ABR3VPT7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-canonical purine NTP phosphatase/PRRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30526" checksum="3DF1D2E6D8DA6008" modified="2025-10-08" version="1">MPQQSTPTPDVPKYDPNGQPILANPSLTLDKAKGQSVLPPLDKTLLHPLRPAINTTGIAYQDANPVNVLLVIPTTNKFKVRLLSEHLSKHKPDHVALSSLEVKADSQVGEQPYDSAGPQGAFNRVANAANKLFADAEEVKKLRDRRVGTVVVGAVENFIEREASYYTAKDGQKKSGPVDYGVLIFCRVSLSPSCPDKERVCWGSPGVSGGVTVPLDFMEWAMKFGFEDEGKRHGKVTVGEVIAANTGIDKADWHEPLAGTSRYDLLKEAMGRMEVPWPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPV1</accession>
    <name>A0ABR3VPV1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF385">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="188" mass="20923" checksum="7E1CC76693B76AC5" modified="2025-10-08" version="1">MANSQRTKVFLEIEWMGPVLDDNHNPVSAEPKEQKGRINLELYDEVVPKTARNFRELCTGQNGFGYKGSSFHRIIPDFMLQGGDFTRGNGTGGRSIYGEKFADENFQMKHDRPFLLSMANAGPNTNGSQFFITTVKTSWLDNKHVVFGEVADKESEKVVKALEATGSRSGAIGYPKRPTIVDCGLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPY3</accession>
    <name>A0ABR3VPY3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="748" mass="81855" checksum="0E76CE65F1E77549" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ47</accession>
    <name>A0ABR3VQ47_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="307" mass="32683" checksum="4CD1AB649B907F27" modified="2025-10-08" version="1">MRVKGEHSELADQRGIAKRGVNDRDHLSCSTTFINHINHASHISSNNNLIPEVSVLSNNMIDPSIRLRRAIHANDALLVRRILRSHPHLLHNPDHSPLDGNANSNLHLAASLGHLSICKLLVELGHEDPTPALNDLHQTAMMLAAAAGHTEVVHFLCESDLSSILRQDARGRDAIMEASLAGHDTVVQILLTYAPGGAAAALANADADGNTALHFASSNGNLLVLRTLLAAGADASRKNAWNWTAEAYSATVAAEVYLKTLVAEMERRKQAGREEAAAKGGGAGAVVRLVDGVNITALNLDIVDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ55</accession>
    <name>A0ABR3VQ55_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61148" checksum="DB960F2DDB43300C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQJ2</accession>
    <name>A0ABR3VQJ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin biosynthesis protein CHS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="42052" checksum="5444A33C61A2EB30" modified="2025-10-08" version="1">MLVSLTVGKVDAGVTVLLTPDKRLIEFPSILLPPDITSGSIVDIDVSRNKKSEAAAEHAFRDLQDQILAAFGTAEPAPPVLRCRNATQTSVVLEWDPIQLATADLISLALYRNGQKAGNIPKPLSMHTTKISGLAVDTEYTFHLVLRTTAGTYASPRVTVRTHKMTDLSGITITTGILPAAVRENLVAAVERIGAKIVDGVRIDTTHFVTTEGRGVQWERANELNIPVVRPEWVEACERSGRILGVTKFYLDAARVGIPYEERPPTAPAPAPAPAPAPPQKDVPPKDVPPPPDANRASMPSTTSGAEQKEEEPKESTSGDSEKGQEEQKARIGGEVEQKALAEEKDQKTLVSRPKPTVEDDEEEGEGEGPSGSDEKGAKSPSGDGSSFQDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQL6</accession>
    <name>A0ABR3VQL6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1280" mass="141408" checksum="C891283BDE8FA4F5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQP8</accession>
    <name>A0ABR3VQP8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="357" mass="37203" checksum="C9E2F80D36EDC315" modified="2025-10-08" version="1">MGKKKRGHPDIEELLARPWCYYCERDFEDLKLLISHQKAKHFKCERCGKRLNTAGGLSVHMNQVHKETLQCVENALPNRSGLDVEIFGMEGVPEDILQQHNQRIIQNFYTAQAERQKATGNPPRGQSGGQGPSKKIKYETPEEIKKRLAEHRAKLAAQKAAAANGTAPPAAPADGQAPAQGAPPFPPQQPGYPYPAAGVPPVSGVPAVPGVPVVPPYGAAPGFPAPTGAFPPGPSPPPGATAPFALPARPPSGSPGAPPYFYGAGAPPPGYPGGAPPAMPAPDSAAAAGDSIDQLIRMAEAGIKPGAAPAKNGAEEAGGAGEKKKKGARMVYADTEVSPEEKMAMLPRYQWVEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR00</accession>
    <name>A0ABR3VR00_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_2308</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="14">
        <location>
            <begin position="39"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="219"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="472"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="16">
        <location>
            <begin position="577"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="11">
        <location>
            <begin position="684"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="12">
        <location>
            <begin position="1062"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1198"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1844251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1219" mass="136040" checksum="A8858CDC1030F794" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR19</accession>
    <name>A0ABR3VR19_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_6390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="498"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1843986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="535" mass="57412" checksum="09A58C5EFE946EEF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR24</accession>
    <name>A0ABR3VR24_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="516" mass="57236" checksum="C3FEB6967FB20C44" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRH3</accession>
    <name>A0ABR3VRH3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045870977" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="685" mass="76846" checksum="6E83DDC5FAE49773" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRP4</accession>
    <name>A0ABR3VRP4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodopsin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12981" checksum="CB2927085B6A7AAB" modified="2025-10-08" version="1">MCIVFTCGEHTFRREVEGYEGLVCRCYNCGNYSASVIKSNPWFTFCFIPVIPLSFKGYEDVSCRICNFQQPLTHRPDVQAMRGQAGQVPMGPPPGGPPGAPPHGWGGGPKPNEPMRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRU7</accession>
    <name>A0ABR3VRU7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_69</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39686" checksum="CFC9C453D638642E" modified="2025-10-08" version="1">MDPSRSSDVSPEAMQARIQQARREAETLKDRIKRKKEELADTTLRAVAAQAHEPIPKSQLMRTKRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYNLNQNRDGPTRVARELSGHAGYLSCCRFINDRSIITSSGDMTCMKWDIETGSKVVEFADHLGDVMSISLNPTNQNTFISGACDAFAKLWDIRAGKAVQTFAGHESDINAIQFFPDGHSFVTGSDDATCRLFDIRADRELNFYGSESINCGITSVATSVSGRLLFAGYDDFECKVWDVTRGEKVGSLVGHENRVSCLGVSNDGISLCTGSWDAFLKIWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRX3</accession>
    <name>A0ABR3VRX3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_87</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="626"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1844408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="899" mass="101660" checksum="402CCD05BDE168E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V186</accession>
    <name>A0ABR3V186_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000610">
        <property type="protein sequence ID" value="KAL1835545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="998" mass="109915" checksum="B6F81369EAC290A8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1C8</accession>
    <name>A0ABR3V1C8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_6353</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000596">
        <property type="protein sequence ID" value="KAL1835588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="13">
        <location>
            <begin position="243"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="563"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="563"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="624"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1835588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="666" mass="74257" checksum="988EAF25D4FF8549" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1Q6</accession>
    <name>A0ABR3V1Q6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000574">
        <property type="protein sequence ID" value="KAL1835657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047444149" description="DUF7136 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="2">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="321" mass="34260" checksum="CAAC651B464788B0" modified="2025-10-08" version="1">MKLSFLLSAAAAAFVTAQDETTEDSPTLQTQFELDIVFPWINSAYNSSDVLPIVFAVQNITALYSLGPNVTIDWNLRPLVARSLSLKFYEDSVDQGSFSIPDPSTLEDPSAPLFLVAATNVNSWIDKIEFHLDFITIQWQIRASGCQPDPVAHGDEFYSFLAVPPKWYDKVSQLITTVRAPEVAASVFETKFEPGDLLPAGCSTTPVAVVDVMGRDETNPTCAVAKELLGMDSYLDPLVPAKVLALTQSCSVVVDEDKAKSLNSQAAAYLASSPGAAAATNVSTTAAPTPTENAAAAVMMMMARPMQMAMAAAVILGGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V230</accession>
    <name>A0ABR3V230_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000541">
        <property type="protein sequence ID" value="KAL1835764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="33"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="425" mass="45960" checksum="F7373CD50B380427" modified="2025-10-08" version="1">MFEYVEFPTLPIVKAHLAINCVVALLAVTAVVLRLIARFTSGAGLWWDDYLVLLSLPQALGMLIIQGMWAPMGVGYDMPATLPNLETILKMLVAYELIYSVSISTVKLSVMFFYLRVFVNRGLRIVIKVFLGFVVAWSIANILQVFLICRPFAKTYTIGIEGECGDQIASFIAIGVFNIVTDVFIITLPLPTVWGLKMSTATKLGLTGVFVVGFLVSVIAVIRIVTLTQLDLENLTGTMVWADFWSATEPLLAVLCVSMPMLGTLASRIFGRRSSSSYYPGGSSSPYGSKNTTALVTIGGSSRNNTKHGMSKLRSVDNTRVDDDGTGDSDTNIPLEGIYAANRTVHYQSAVEKGTPLGEGTTTTAAAAAVGHNRNGSGQAYQHNAVHEDNHSGSEVGLTMADERAKEVDLEGGIRVQTKWSITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2F6</accession>
    <name>A0ABR3V2F6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000493">
        <property type="protein sequence ID" value="KAL1835962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="409" mass="46558" checksum="7709995A52AC27B3" modified="2025-10-08" version="1">MAPRRRRGAGQDAGDDASSETDNAHKNRPPNTAFRQQRMRAWQCVLTPKLIVTIFSILSAIYLGFGAYLTYLAHTVRDIRIDYTDCVKDAPKDQFGPLPSKYITAHFSNSESNFDPMVAEWKTEEVTVQGPDFEDDRIMCRIKFNIPEDLNPSINFFYNLENFYQNHRRYVNSFNAKQLLGDAVDGRTINDSTCKPIASDPQTGKIIYPCGLVANSIFNDTFSNPVLLSVRESTADNETYAMTTKGIAWPGMKDLYGPTKYQLDQIVPPPNWQRRFKNGYTEKNKPINPAEDEAFQNWMMLAAAPNFYKLYQKNERDVMKAGQYQVDIEDNFDTTVYNGRKAFVITTLSTMGSRNIWPGIIFLIVGGLCLILDVYFILSFFLWKPRKLGDPSYLSWNQPAAPQNHGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2M2</accession>
    <name>A0ABR3V2M2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000479">
        <property type="protein sequence ID" value="KAL1836025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="3">
        <location>
            <begin position="222"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="742" mass="79113" checksum="70B82E8170FBA777" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2Q8</accession>
    <name>A0ABR3V2Q8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_5618</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000471">
        <property type="protein sequence ID" value="KAL1836067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="87"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="206"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="322"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46931" checksum="9218332BF162F2F7" modified="2025-10-08" version="1">MFALSEESRERIARIIEVGRVALHYGYLPLILYLGYTRSNPRPSIIRRNNPPPDHQPNFQPALTPEHVATTTLTGVSMTEINHAGLSPALVETVAGLSAGTIATLIVHPLDIVKTRMHVYRTAHVSPLLTTPLPRPSAVQLLHALLRSDQPLASLYRGLTPNLVGNATSWASFFFFKSRLERAILLVRGTTTTTATTATGNNNESLTPSDFFLASLGAGALTQLLTNPIWVLKTRMLASDRGAHGAYPSLLAGAARLWREEGPRGFYRGLSVGMLAVSHGAVQFAVYDPLRRAFLLSREKTRRRRRGEAHETTTAGFGLSNEATLVLSTASKLAAGVTTYPLQVLRSRLQHHDADAQFGRSARDVVARLWREEGMRGFYRGLVPHVVRVLPSTWVTFLVYENARYYLPRWWGGRQVSEGEGKVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2T8</accession>
    <name>A0ABR3V2T8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">VTJ49DRAFT_5571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000465">
        <property type="protein sequence ID" value="KAL1836099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13952">
        <property type="entry name" value="7tm_classB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="320"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="598" mass="66230" checksum="4FA5EEB9922F45B7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3B2</accession>
    <name>A0ABR3V3B2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000446">
        <property type="protein sequence ID" value="KAL1836214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="58"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="335" mass="36389" checksum="4D3955235AE9C37E" modified="2025-10-08" version="1">MAQLTLPTRTTRPSSNTSLYADTTDTYNHNALTTNANDDDSDSDSQPDPTALPFPAALSRSDFLQPDFNPAAYLSSLHASGPASRHQTLEDLRAELRDRGAAARAELVELVNAHYAAFLNLGAGLSEQGGADRAADVRVAIMGFRRAVDELRQKVKQRRTEVGRLVGELEGVRGAVEMGRRMLELEERVAGLEGRLEVGFQGRRGATKKAEREEDGDGEFEVDLDSLDGDDEEETDDATDEAGFVSSSPAKLAALAEEYVAAEGIADALGRNLPFVRKMEERMTRCRNTILLDLSTALAEARKAGPKGHGRVVKYLGVYRTLNAQADAIKVLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3S7</accession>
    <name>A0ABR3V3S7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI inositol-deacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000412">
        <property type="protein sequence ID" value="KAL1836434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="83"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="372"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="641"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1311"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1312"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1335"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1356" mass="152050" checksum="C9A279F19B8F30EA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3S8</accession>
    <name>A0ABR3V3S8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000410">
        <property type="protein sequence ID" value="KAL1836442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34726" checksum="F0C8BBFD4BB3A84B" modified="2025-10-08" version="1">MPMALLSPSTGLVVDSSSSKAMKVWKDVLLRLTPEFMPVTFNLPWPLPKPIPTEPIRNLCETLQKNPTLNPGEWYGRLAGGQPLALSKSFCAVQAPYFDTGIHEDCDLVPLSEVVSGPVARTRPVLHDEKIHLAKIIVMAMIQLHDTPWIPEIPTLDIIHLAKKNGVISYREAFALHTSSTFSRPHGGHRYTDSGTMPNGVSTNAPNSDSGDILNSARMLGLGMILIELMTGTLFLNRHFAPFPTSWNFWEYAAAYEAATQHLGMVNRIGGFNYYRAVSLCVRNTLFDKPSMPEQLFGILEILEKEEVQGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V431</accession>
    <name>A0ABR3V431_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_5031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000398">
        <property type="protein sequence ID" value="KAL1836534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF23">
        <property type="entry name" value="ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046027863" description="Peptidase A1 domain-containing protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="115"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1836534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="427" mass="46258" checksum="22EDFF5274F1C079" modified="2025-10-08" version="1">MSLVNVMLRFILLLLWARSTVAVPSNIQKRSFKLDRIKNPHFQRHNGTRQLVNAYQKYRMPIPQELLDALDRQVEDGTVSSSHQPASVSSFHVSETDGTTTGRVPATPANEGVEYISPIQIGGQMVNVAIDSGSADLWVFSTLLPPFARAGHQVYDPALSPTSKILSNASFSIFYGDGTSASGSVALDTVDVGGAVVWNQAVQMATWVSSAFVRDTALSGLLGLAFSKLNTVKPVRQTTFFENVMPTLAEPLFTADLPKDDVGAYEFGHIDSSRFAGHLAWVAADTSKGFWQIWTAGFRVAGGSQKIVPASPAIVDTGTTLMLASKEMVDAYYNHVPGARRSPVYGGIAFPCNVTLPDLWLDVGGTYTAKIRGSDINFGPITDELCFGGIQRTTSQFQIWGDIFFRSQFVVFHGGNHSLGMAPALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4G4</accession>
    <name>A0ABR3V4G4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000407">
        <property type="protein sequence ID" value="KAL1836462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11887">
        <property type="entry name" value="SH3_Bbc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035552">
        <property type="entry name" value="Mti1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="713"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1147" mass="122560" checksum="34F65D6344B8565A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5H4</accession>
    <name>A0ABR3V5H4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000395">
        <property type="protein sequence ID" value="KAL1836568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="618" mass="67494" checksum="39444EDEB5BA5A1D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5J0</accession>
    <name>A0ABR3V5J0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000379">
        <property type="protein sequence ID" value="KAL1836686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="683"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="746" mass="84431" checksum="353A47DC1A9129CB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5N7</accession>
    <name>A0ABR3V5N7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000333">
        <property type="protein sequence ID" value="KAL1837069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178">
        <property type="entry name" value="SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178:SF0">
        <property type="entry name" value="SERGLYCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="540"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="885" mass="93670" checksum="17710A3A4404E735" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5S2</accession>
    <name>A0ABR3V5S2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000328">
        <property type="protein sequence ID" value="KAL1837113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="29"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="341" mass="37491" checksum="32A70403898E069B" modified="2025-10-08" version="1">MSSAALINVDDGDAMEPTLQSLLDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKEARQVDGFDNLYAMEIDPNGSIQDLMAGQTDGADGNDMGGMAGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPSVLEKALAKVSQLSSQYGSLLNGVLGGSGALPNGANLNEMMEKLETLRAAISEVNAQFKDDRLTTFVCVCIPEFLSLYETERMIQELASYGIDTHCIVVNQLLFPKPGSDCEQCTARRRMQKKYLDQIEELYDEFNVVKMPLLVEEVRGKERLEKFSEMLIKPFVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V617</accession>
    <name>A0ABR3V617_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000318">
        <property type="protein sequence ID" value="KAL1837207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046228833" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="255" mass="28551" checksum="B018ED260100F7B6" modified="2025-10-08" version="1">MKTVLISVLPLITPAFAGFHDWKPPGKNDVRAPCPMLNTLANHGFLPHHGKDLTRQQVVDALYNGLNVDKSAGSSLFDFALMTSPEPNATTVSLDDLGRHNILEHDASLSRTDAYFGDVLKFNKTIFAETKRHWGRGKILDVPAAARARLGRIQTSKATNPEYTMSELGDVFTYGESIAYLIVLGNIKTGKAPRRLVEYWFENERLPTHLGWRRPSESLTIDHLDQYIYLIRNITLTLPGGTDPVKRRAASHFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V636</accession>
    <name>A0ABR3V636_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000321">
        <property type="protein sequence ID" value="KAL1837171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="419" mass="47711" checksum="F641026EDFC7208A" modified="2025-10-08" version="1">MMGKPSTTPPPVVPGGSSSNPDSGMPVRGHPVLNDEDAPVLRPDDLPPLYSDIDNDTTDPHSRFISDLTSADADWNSETYYVSQRRIDSDGNETVVSKRLDEDPELLQAFIQEAAAIAPRPAIRITGTHTERRTTVDNKTESKTVVDFDIQLPLRPYLFSDPRTGESWARLRTVENVEVARRGTIFSKRAPVPPHLKQQQQQLRDVEQPGGRPAVDAMPKPTLKEWCHRYCASNAALKSFVLRRRVLGFDQDRMSVLLKDLVRGTGYRGKVSIKYPVEGEYVHVMNDCRINRWRATGWIRWMFYLSFLWIFSWPVLFFSTKRWEVAVAEWPFSTREPDLSRRFVSMSEDHIYNLWGRAIRSAVLGRRQGTLDQRDLLTAETRPNDHFQHALGGSSPALLKHTLNAMTANDEQVGWGRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6J6</accession>
    <name>A0ABR3V6J6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000319">
        <property type="protein sequence ID" value="KAL1837197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40108" checksum="60BF466837DFD240" modified="2025-10-08" version="1">MCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFSLPHAIARVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTAAQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGLSDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6L0</accession>
    <name>A0ABR3V6L0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000299">
        <property type="protein sequence ID" value="KAL1837394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="559"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="484"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="624" mass="67682" checksum="69D89D902820EA7C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6R6</accession>
    <name>A0ABR3V6R6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="4 8">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="4 8"/>
    <dbReference type="EMBL" id="JAZGSY010000292">
        <property type="protein sequence ID" value="KAL1837462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="9">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="9">
        <location>
            <begin position="170"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="327" mass="36943" checksum="22C9FF364AEC1F80" modified="2025-10-08" version="1">MASTTDTKNYKFNHTMIRVKDPQESVKFYSFLGMSLIQKLSFPDAKFDLYFMGFDGPGAPSAGNNLWDREGVIELTHNYGTESDPNYKINNGNVEPHRGFGHTCVSVDNIQAACKRLEDAGYKFQKKLTDGKMRHIAFVLDPDGYWVEIIGQKPIEETESVTTTDTATYRMNHTMIRVKDAEKSLKFYQEVLGMSLFRTHESPAGGFNLYFLGYPGEKGLPAEGPGAVAGASTADREGLLELTWNYGTEKDENFKYHDGNSEPQGFGHICISVDNIQAACDRLESLNVNWKKRLTEGRMKNVAFFFDPDGYWVEFVQNERFSGKSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V719</accession>
    <name>A0ABR3V719_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="3">SDH assembly factor 2</shortName>
            <shortName evidence="3">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000282">
        <property type="protein sequence ID" value="KAL1837562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="235" mass="26158" checksum="286F61B9DAE9FE84" modified="2025-10-08" version="1">MKMTPLRPAVRAITSRARPGLASLTSVVRHNTPQKCFKSSSSSQQPPRNNADTPPSHELDVGELQGASFKIEPLRRVGEDPSTMRARLLYQSRKRGTLESDLLLSTFAAAHLATMTPAQLAEYDRFLDENDWDIYYWATQDETPLPSASSTSSSSSSAQQQQQEQETPVDPATQPSPRPGEWAQTVGTFKPAYRPVPARWKDSQVLRMLREHVAKRRGQDGGGMGFMPSLDEYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7U6</accession>
    <name>A0ABR3V7U6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000256">
        <property type="protein sequence ID" value="KAL1837870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046027864" description="Beta-lactamase-related domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="85"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="410"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="61194" checksum="4882DC5243970504" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V831</accession>
    <name>A0ABR3V831_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000248">
        <property type="protein sequence ID" value="KAL1837968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="122" mass="13315" checksum="CA52341C02CA9198" modified="2025-10-08" version="1">MAGKFEPKVPVQLDPPKDDPISPEELAKANGVDGAKCYVAIKGIVYDVTGNKAYQPGGPYHVFAGKDASRALGKTSTKPEDVSPEWKDLPDKEKGVLNDWITFFSKRYNVVGRVEGATNFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8A2</accession>
    <name>A0ABR3V8A2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3174</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000248">
        <property type="protein sequence ID" value="KAL1837966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="218" mass="23780" checksum="AEB68D614B134679" modified="2025-10-08" version="1">MTGMAGFTDFPSPPSSMYYVYGGESEPYLSESNSSPNNSTYDVTSAADGTLSSRYPSPAHEEAESGDSAEQPKPPPKRKRENRYKNAPPAVLSRRRAQNRASQRAYRERKDQRIKDLEQMLNDAKQRNLVLTQAYAALHAEYVALKTSQMPGDVSSSYQPQPGFDPAVAVMPSPLPYNATTPGMLPPHLADPSTVGTFDVGDPFIPYGDLAATTPYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8C4</accession>
    <name>A0ABR3V8C4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell cycle control protein cwf14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000244">
        <property type="protein sequence ID" value="KAL1838009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17155" checksum="98032F435E6DDC46" modified="2025-10-08" version="1">MPAIRPASKRKPPPDGFSDIEEDLLIFANKMKDAQNTPTDNVPKHQAQWPIFQIAHQRSRYVYELYYEKEAISRQLYEWLLKNGYADAMLIAKWKKQGYEKLCCLRCIQTKETNFNSTCVCRVPRAQLKEDQDVQCVNCGCRGCASTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8H6</accession>
    <name>A0ABR3V8H6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3937</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000300">
        <property type="protein sequence ID" value="KAL1837378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="427" mass="46697" checksum="9ACDCB902F433805" modified="2025-10-08" version="1">MAAAAKVSPGRAAGLYAAAAALRLAVFAFLPGLSDLLAARVEVSTPVTSFKRLQEGLFLYNHNVSPYDGGVYHQAPLLLPLFSLLPNFASLPLLTDLVYVVLDLLSARALWRIADSGEAGSSAQFTSPRRAKRWSGFVLAAFFLFNPFTLATCLGRSTSVFTTCAILHAIASAVSGAPFSAMVALTFAGYLSLSPLLLLPPLILLAYDRRRPGGPIPQSGPAFAAVCVAAVAGVLGALFLLSYLVTGSWEFLPSTYGVQLTLSDLSPNIGLWWYFFVEMFDSFRSFFLAVFWLHLSSYVAGLTLRIRRQPLVVLTLLLGILAIFKPYPSIADTSLFLALVPLYRHVFPLMRYTFLSASVILYSAFLGPAFYYLWIYAGSGNANFFYAITLVWGLGQSLLVCDLMFAVLRDEWEVERPEMVGKEIRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8I5</accession>
    <name>A0ABR3V8I5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000241">
        <property type="protein sequence ID" value="KAL1838055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="443" mass="50726" checksum="55E0B3A05197305D" modified="2025-10-08" version="1">MPNRRVLLNLGIFTIACLVIAGIAFPSSRVTIQDLVVQKVQEAKGAKPGPPVKKYKPEPTYVPPPIRENFPLLATSPPPPIPKWNQPREDMYKEYHLPVAPPLLIGFTRTWPVLQQAVVSYITAGWPASQIYVIENTGVQQANARGQLSLQNPFFLNHTALKALGVNIIQTPTLLSFAQLQNFYLSLTYEHNWPYYFWSHMDVVALSFEDGGGGMTVPYNQPGYKTLYELALAALRNQRAKGGKWAMRFFAYDHLSLVNPEAYEDVGGWDTMIPYYATDCDMYERLRMKGWSIVEDRVGIITDVASAFEDLRVFYRVDGVQAKFVDPNPPPPEKNQRRDTDGVTRRDEEDPNLAKWHALRITSDNMYHHKHGNRGRNTWQLGQQGGQGEPFYYPQQGLAEALELITETGREIFRRKWGHRDCELIKDGHRVYDDAWRLEKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9C6</accession>
    <name>A0ABR3V9C6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000213">
        <property type="protein sequence ID" value="KAL1838448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="160" mass="16551" checksum="63D2B1996B5D5E86" modified="2025-10-08" version="1">MSAAETAPKTDAVQSQPAEQQQQQQQQEPTTTAAAEDKPAEDKPASEKEKKPNPLKTIGSVIKTLLGCLRRPAVKEAQDRALDEAAKAATEGDKTDATAAGTESNAATTAAPPTLPAPKTETATVTAVAPEQAQGEQQKVEGEKKEGGVTTISAQPPVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9D0</accession>
    <name>A0ABR3V9D0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000218">
        <property type="protein sequence ID" value="KAL1838378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="99"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="622" mass="69891" checksum="1C0A8FC1A8E3C0C8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9J4</accession>
    <name>A0ABR3V9J4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_2698</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000217">
        <property type="protein sequence ID" value="KAL1838386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="16">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1838386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="131" mass="14246" checksum="605D27F808A10B84" modified="2025-10-08" version="1">MESGPDARVGQWASVLVFLTSLRQTGWSDQQTLLQLARSDAQQPHLFIPDPQDMENGAATQGEGAKDPSGFLSEIIGNPVTVKLNSGVVYKGELQSVDGYMNIALEKTEEYVNGVKRRSYGDAFVRGNNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9V5</accession>
    <name>A0ABR3V9V5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000207">
        <property type="protein sequence ID" value="KAL1838557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="174" mass="18831" checksum="610386661A38D972" modified="2025-10-08" version="1">MSTGPGNSGSQHGYHASPAARSQFGTSRLSSGYTSSSLAEYDSITPQMRDRQARGKDPYDDDDGLGDGNLNERSTLLRLGSGRAEKEDFYMAETRQRAIAFLDNPELLEMHALSTGLSIAAARLHFMKQLCGYDEDEKPGNSSALSSSPQSRRTKEAPGKRRGPRSDSDPAGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9X5</accession>
    <name>A0ABR3V9X5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 5B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000220">
        <property type="protein sequence ID" value="KAL1838352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="500"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121278" checksum="7E6AD8BA5AE19DC7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA31</accession>
    <name>A0ABR3VA31_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_2293</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000198">
        <property type="protein sequence ID" value="KAL1838703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="644"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="558"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="673"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1838703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="924" mass="100952" checksum="556EA4F728ADC855" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA34</accession>
    <name>A0ABR3VA34_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000198">
        <property type="protein sequence ID" value="KAL1838695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="906"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="532"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="748"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112794" checksum="0F695AB657F13C6B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA56</accession>
    <name>A0ABR3VA56_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000205">
        <property type="protein sequence ID" value="KAL1838596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="249"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="454" mass="50241" checksum="4F298C6918C265F8" modified="2025-10-08" version="1">MRGEVLHVHLGQAGAQLGNSAWELYLLEHGLGPDGRPDPNAKDLAEGGSFETFFTETSNGKYVPRSIFVDLDPSPIDEIRTGTYRQLFHPELLISGKEDAANNYARGHYTIGKEMIDGVIDRIRRVADNCNSLQGFLVFHSFGGGTGSGFGALLLERLSTDYGKKCKLEFTVYPAPRLSSAVVEPYNAVLSTHSTIENSDCTFLVDNEAVYDICRRNLDIPRPSYEHLNRLIAQVVSSITSSLRFDGALNVDLNEFQTNLVPYPRIHYPLISYAPVISAAKSAHESFKVSDLTFQCFEPNNQMVVCDPRKGKYMAVALLYRGDVVHRDCSAAVAQLKAKASFNLVEWCPTGFKIGINYQKPVAVPASPQDGGLAAVDRSVSMLSNTTAIAEAWSRLDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVAAESFDEGEGEGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA63</accession>
    <name>A0ABR3VA63_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OCRE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000214">
        <property type="protein sequence ID" value="KAL1838442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16074">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="OCRE" evidence="7">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="785" mass="85839" checksum="CAE9BF5795AE2293" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAJ0</accession>
    <name>A0ABR3VAJ0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000195">
        <property type="protein sequence ID" value="KAL1838744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="271" mass="29367" checksum="3E9D497DCEE51242" modified="2025-10-08" version="1">MNAPSLQLVSITITHSQNITMGRSTPRKSRQRGQPGSGGNGPRQVAASDYESDTAQYLERREAEASTTNTNPQPARDNTELSLRVLRRYRPKIQSILAVAANAVAYHFLESTQGWEKHGVEGTLFVCDQDPVVTPTGHALPHVCVFVLNRRSMDNLVIDLLNVTDCEVVGELIVFRLADEARQKAPGEEDGSAKKIIGLWLHADESNTRELHASLITAAWQQARQAYDAYLQAATAAVVASNGVSTGGDLAGDYGGGKRLSVSELFRKNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAJ9</accession>
    <name>A0ABR3VAJ9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000212">
        <property type="protein sequence ID" value="KAL1838466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="548" mass="59436" checksum="4F4B37649A6BAD5D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBN5</accession>
    <name>A0ABR3VBN5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000174">
        <property type="protein sequence ID" value="KAL1839122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="191"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="293" mass="32550" checksum="9375E4BA6BCC2DCC" modified="2025-10-08" version="1">MPRDHEPSLNEKQFVTQALQENLRLDGRELDQYRPLELRFGDQHGVAEVTLGKTKVLARATAELTVPYPDRPLDGIFTISTELSPMASPSFEVNRPTETEILLSRLLEKTVRRSGALDTESLCLVAGKQCWSVRVDVHVLSHDGNLTDAACVAVVAALRHFRRPDTSIAQGVLTVYTPAEREPVPLSWLHSPFCVTWSFFGEEGTTALLDATWLEEQVRVGSCTFSMNQHGEICQIAKLGGVPVDAVALLQCASVSLTRVKEISDLVDRRLAEDLKRRDKGGFMAELRAENDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC47</accession>
    <name>A0ABR3VC47_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000177">
        <property type="protein sequence ID" value="KAL1839072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047129199" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="34"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="500" mass="54988" checksum="6E005EDF27F94FD0" modified="2025-10-08" version="1">MKSSISLAILSSLGGAHAFWRMECRGRVGLARLDPLVDPGTLSQHVHAIHGSSGFSESSTYEDLVNADCTSCAVLEDKSVYWAPSLYFHHADGRFEEVGQEGGMLAYYLLFEDRKDEGKGIKAFPNDFRMIAGDSSRRNYSVAGLDHRLPDPPMALWGLLGQTTQEALRQRAIGFNCLHYGKGDNEATLWRHYMPDKSYIDQNCQNGVRFEIAFPSCWNGRDISSPDHKSHVAYPDQVMDGRCPEGFDVKLPTLLYETIWKTYDFAGLPGEFVISNGDPLGFGYHADFISGWDVNFLQQAVNQCRDDSGSIYACPLFTIQDESEQKKCKLPDLPSIASEKVSGVIGNSLPGGVTIQRGPEPARKPAVEAPQFVPAGAPSPNDLPGGVFQEIEAATSVQVVEAAEVPEPTPEVPSPTPEPPEPSDPPVPEGYELVRTDYVTDGRTVSKIVVIETVETIMMTTETVTVTVSPTGNARRDVHGHQHHHNHRRHRHGHGMRHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC82</accession>
    <name>A0ABR3VC82_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM5</name>
        <name evidence="11" type="ORF">VTJ49DRAFT_2002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000181">
        <property type="protein sequence ID" value="KAL1838991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="87" mass="9373" checksum="0D499945B05A23D7" modified="2025-10-08" version="1">MASQLLPLELIDKCVGSRIWVIMKGDKEFTGTLVGFDDYVNMVLEDVTEFDYSGTHSKLKKILLNGNNICMLIPGGEGPTGIAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCN9</accession>
    <name>A0ABR3VCN9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000153">
        <property type="protein sequence ID" value="KAL1839511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="376" mass="41132" checksum="163C84FF0BBE2E31" modified="2025-10-08" version="1">MADPLSIASGVVGILSTVQTLLSDFDNIINAPKTLQSLKTRLKQLDQALASLQSVKDEEWQSLGDSVVAQSRTALESCEKTCNQLRTTLDRWTRRTGKGELKLLDRFLFGYFRQPQVKSINDELSQALAEITALAATANLKSSFQQRDDLKPVILAHQSAMASTVLTDQTNSVEDTVPAWLRNTDVSDETKQLVTYRPSEIIDPADRSTSTRQTMSDAPQSGQFLTPVTRNHFGDGNEGAQVGTHHGHIEAVIPSTRTDRGAPREESPEATPTQAKGDDLNLQFPLPGTTNYFGAGNRGGQIGDHYGRIDLVRGDRGASPEETPDEAPDDRPTTVNAPRRVLKHQAPASRVINNFGRDNEGLQIGTSYGKLVFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDD7</accession>
    <name>A0ABR3VDD7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="68" mass="7514" checksum="951CAFCAC68A7A1F" modified="2025-10-08" version="1">MTCPFLRPMTGGRGLGRCRQHMGNIRHTGNPDPGRPRITVGRDLHVIGFVLPAPPLLLNWFSLPQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDS0</accession>
    <name>A0ABR3VDS0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1267</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33751" checksum="2DF5AF56798D3036" modified="2025-10-08" version="1">MMQPLPSPAPGTRYHEIRFDDVADDEKHSTALLDPTDPFYKAVDEERAWSDITAGDPEMPQRRASRRQRIWNAIMSVRSLVDTALLVVILVLVLDRGRNRSAPPVDVDVGGDITGFAPRFPKQIKSFSPDPTFFPENGEEFFTDEVQERWLTIVPRGLGYVHINTNTTTHRYDNLPTPLSHYPPSTFTTSLTHQLHCLHTLAGVAAAFTAGRPELLHQDENEDEHEGDDAAWHLGHCIDYLRQSIMCSGDVTLEGQHTTFPERVKGSDGWDGKHVCRDYGAVMRHLEEWRVDDERWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDU5</accession>
    <name>A0ABR3VDU5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="122" mass="12877" checksum="E51741D78AD9F9F0" modified="2025-10-08" version="1">MGLAAVFEIRPPGQKDIGLASGVLTLEHRVSGQARPVRALVDVNLILESLGWQQTRAGEWVNVIGYITDPPGEPHGNGPAYGGLTVHAQAILLWSAGPVDPQQYEASVRALAETSHSSVCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VED0</accession>
    <name>A0ABR3VED0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_1316</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1839613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="152" mass="16815" checksum="8639BF105E76E89C" modified="2025-10-08" version="1">MDHPQRPQSSLLVAPPELSPIEQEVLDEYERLAENMKKLATLLDHLASAPATEILDGLRDLERKTSLVFTLLKASVYSIVLQQEIDWDGGGGGGQGQGHGDGHGDEDASTTPTPPRHRMARSRFFYMISTEYRAVYLNPSTSPCTMHVTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VED8</accession>
    <name>A0ABR3VED8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="623"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="871"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1201"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1403" mass="154453" checksum="BB0999EF4FCAE48F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEQ5</accession>
    <name>A0ABR3VEQ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="26856" checksum="32BEA057365C2060" modified="2025-10-08" version="1">MTTQTPAISKAFYAIIAGVGGGTGRAVALRFARTYPVAVLARTEASYAGIVDEVVRRGGEAVGVSADVADEKSLASALEVVREKFKGKGLAVGVYNVGAGLSIKPFLETTVEDLDQSLASNVRGLYNFAHSTLPSLLDSVSANPPYPPTLLVTGATASLRGAARFGTFAAGKFAVRALSQSLAREFGPQGVHVAHVVVDGVIEGPRTKGYTVNEGVEDGKLDPEAIAESYWHLHTQHRSAFTHELDLRPYVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEV5</accession>
    <name>A0ABR3VEV5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_678</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1840247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="353" mass="38719" checksum="A29CBE477663EC96" modified="2025-10-08" version="1">MGWFWADSTPAASAVPPADARHKHLSQSGGAPPPGCPMHKATTEAFKSAAAPSSSAPSSCPVPHGNPSANAALSSCPVPHGNPAANAALSSSCPVPHETPSSTQDEPSLFSKLNPLNYMFHSISQERAPNQTYALPTTRDESSIPRGTGEGNWEYPSPQQMYNALLRKGYTDTDITAVESMVAVHNFLNEGAWSEIVEWERRFARGLGRGWAVSRRGEENAELELRRFEAREGGQVSPTLIRFQGRPKDLTPKAAILQMLGRVYPSKFATEPPFDRHDWYVSREADGQKKEVRYVIDFYSAPPEPTGEPVFYLDVRPAMTPTGAVERLMRWGGDVWWRASGGEVREANKRNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF61</accession>
    <name>A0ABR3VF61_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000110">
        <property type="protein sequence ID" value="KAL1840504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="68" mass="7668" checksum="624234CC55DF6C1F" modified="2025-10-08" version="1">MSPTSRSSSRRCARASSSPTPTLTPRPRSRCQCPQSFLEFCLSCADFGLLQCQGYAKFTYPLKQFEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFN9</accession>
    <name>A0ABR3VFN9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000114">
        <property type="protein sequence ID" value="KAL1840415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59204" checksum="EEFF7709C4637837" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFS6</accession>
    <name>A0ABR3VFS6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="393" mass="43747" checksum="FBDE888F8A7B1A65" modified="2025-10-08" version="1">MASTSESSASPQGQAEKPVVIVTVGMAGSGKTTFMQRLNAHLFQNQEPRYVMNLDPAVAKLPFQCNLDIRDSVNYKKVMEEHRLGPNGAIMTSLNLFTTKVDQVLNILEKRAVPDPENPSRKPVKTILVDTPGQIEVFVWSASGTILLDSLASSFPTVIAYIVDTTRACSTSTFMSNMLYACSILYKTKLPMVVVFNKTDIQDAGFAKEWMTDYEAFREALDGDENKNAFGGQDGGSGYMASLLNSMSLMLEEFYSHLKVVSVSSVKGTGIDDFMDAVKEKVHEFNTVYQPELDRRRAEREEIKKKQREKELEKMMRDMSMDGLTAAAPEENKSDDEDVQEPTPDGDSDDEIDDENDREGLQARYAASLLGKDSVTEEASFAKYLHSQRNATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG31</accession>
    <name>A0ABR3VG31_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetrahydroxynaphthalene reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28528" checksum="C228F67DBEA50776" modified="2025-10-08" version="1">MVIPIPTVSLEGKVALITGAGRGIGRGIALELARRGASVVVNYVSSAGPAQEVVDEITSYNNGARAMAIQADVSKVSEIQRLFTEAKHHFGRINIVMSNSGTESWDKTEDVTEEKYDHVFNLNARAQFFVGQAAFKYLEDGGRLILMTSIAAGLLGVRNHALYNASKMAVIGMVKAFATDFGVRGITVNGVAPGGIKSDMFTENAWHYIPGGTPDMPAETIERLMAEHCPLGRCAVPEDVARVVAFLASEDGGWVNGQIITISGGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG52</accession>
    <name>A0ABR3VG52_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_206</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000102">
        <property type="protein sequence ID" value="KAL1840711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="376"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="752"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="755"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="812"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="829" mass="93726" checksum="28946AB88BD7316E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGC0</accession>
    <name>A0ABR3VGC0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="167"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="526" mass="57776" checksum="28562F3032DB504E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGI6</accession>
    <name>A0ABR3VGI6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrofolate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50065" checksum="5AEA1BAFB2F577D7" modified="2025-10-08" version="1">MIDLGLARVGRLVQQTPQTWKAIHVAGTNGKGSICAYLSAMLVASGRSCARFTSPHLIDRWDCIAINGKPIPEAVFTDAEAVVKQRDADGRIGATEFELLTATAFEIFHRQRVEYGVVEVGLGGRLDATNVLKQKAVTVIAKIGLDHQSFLGNTIEEIALEKAGIMRPGVPCVVDGSNQPSVLEVLEEHARCIGTELHLPSTAGISDALDGLRLEPHQIQNLACAHLAFRLACPEHDQPLVHFLPAIRQLEWPGRLQKLNIQPIINRPQEVLLDGAHNPQSAEVLAHHLIVVCGHAIWLGGPKNGWDEAEWLIEEYKKGETPTFIEHIKAGVKLLSEDEDSVLVFSGGPTRKEIRLSEARSYYNIAVANTFFNLLPSASTTDANPLLNSRILLEERALDSYANILLSLITFWRHHSCWPMRLTIVSHGFKRVRLVDGHCAAIGFPLERVRNDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGN1</accession>
    <name>A0ABR3VGN1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteasome activator subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_7608</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000093">
        <property type="protein sequence ID" value="KAL1840949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="12">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="389"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1365"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1876"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1964" mass="222737" checksum="BBA4F0FB3102F959" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGX7</accession>
    <name>A0ABR3VGX7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="544" mass="61139" checksum="D212254959403A3A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHF3</accession>
    <name>A0ABR3VHF3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000093">
        <property type="protein sequence ID" value="KAL1840947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="720" mass="76936" checksum="3FB2206F6B3303E4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHH1</accession>
    <name>A0ABR3VHH1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="67545" checksum="32951D5B0C2FE878" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHR2</accession>
    <name>A0ABR3VHR2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="207"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="638" mass="69092" checksum="17051DB9C212C533" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHS7</accession>
    <name>A0ABR3VHS7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="395"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="494"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="683"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="774" mass="85460" checksum="4957D5F043043C69" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ08</accession>
    <name>A0ABR3VJ08_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1195"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1303"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1337"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1459"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="151"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="841"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="793"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1559" mass="174077" checksum="5A0C131B283A6D99" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJI3</accession>
    <name>A0ABR3VJI3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="78"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="397" mass="43275" checksum="C8A986DC25DBA731" modified="2025-10-08" version="1">MSQLVNAAGEIAFLGGDIGTNREMTKQSPDLISQVITMLWSTLILAALAEAAPQFGVGGNRATMLRFGCSQLVIDRIDPLVNPGQVPSPHMHQIVGGNAFNASMPHTDIAELATCTTCSFSEDLSNYWTANLYFRARNGSYKRVPQIPNRLLFGDHFTTQTKGGFVVYYVSPGPGAVTAFRPGFRMLVGDANQREKLGEGMVSQTCFRCYSGPDWEGDRYAPCADPSVDTEELPPKPCYGIRSNILYPTCWDGKNLDSPDHKSHVAYPVTGPQTFTGNSVGGECPETHPVKIPQIMLEIVWDTTQFNDPDLWPEDGSQPFVLSTGDTTGYGQHGDYVFGWKGDSLQRALDGGCFGASCTALKSQSVEEANRCSVPELVDEDVDGWMDTLPGWDSMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJN2</accession>
    <name>A0ABR3VJN2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_6888</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="56"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="299"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1841578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="395" mass="45443" checksum="F88A19D55C1DEDD4" modified="2025-10-08" version="1">MKEENGKRKASEEPASPTASKRVKHDSDEPEAKPAKIPAIPFPEKPAVIEERNGEIEFRVVNNDNTRESLIILTGLKCIFQKQLPKMPKDYIARLVYDRTHLSIAIVKKPLEVVGGITYRPFKGRKFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSDVMHFLTYADNYAIGYFKKQGFTKEITLDKSVWMGYIKDYEGGTIMQCTMLPRIRYLEMGRMLLKQKECVQAKIRAFSKSHVVHQPPKQWAKGNVTPIDPLSIDAIRASGWSPDMDELARQPRHGPNYNQLLHLLNDLQNHPSAWPFLVPVNKDEVLDYYDVIKEPMDLSTMESKLEADQYNTPEEFIHDAKLIFDNCRKYNNENTPYAKSANKLEKFMWQQIRAIPEWSHLADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJZ5</accession>
    <name>A0ABR3VJZ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_6564</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="158"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="347"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1841811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="598" mass="66595" checksum="E1745D106A46D65B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK14</accession>
    <name>A0ABR3VK14_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="563" mass="61254" checksum="CC419317D3AA4CD0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKE8</accession>
    <name>A0ABR3VKE8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="375" mass="40001" checksum="A090B0D6ED215DF3" modified="2025-10-08" version="1">MSNAAVGPIYDSIISEVINSVRVDFEETGVDESALEDLKKLWQSKLSQMNIAQFPWDPKPDPPPAPADTNAPATTAAPGAPAVGAAAYTQASLTPQPSAQGLTLPGSVMPVSNGGAVKTEPGYSTEPAIKQEPGISNPMMPAYNPANGARATAAQRAAMALENQFGQRAAASINALQNGMAAPQQQPQQPADPQQQYRQNLAASMQQRMQQQSPRPPNGLPTSQMDGSADDAAGQEDQPAATIPDRAEIDAHLHAQLIARAKEMEGGGLMVPLCKAVKDCSIVTKRSSGDGAGQFDGPDEDMDGDEDAINSDLDDPDEAADDDDEDEDEMGHMMLCLYDKVQRVKNKWKCILKDGVLTVNNKEYVFHKATGEYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKF7</accession>
    <name>A0ABR3VKF7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="845"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="870"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="892"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="920"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="984" mass="108931" checksum="52FB0865BCB770FA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKG8</accession>
    <name>A0ABR3VKG8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="844"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1102" mass="122066" checksum="B789DF93301ACD66" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL32</accession>
    <name>A0ABR3VL32_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="168"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="271" mass="29046" checksum="FC1155C1FB3BE51B" modified="2025-10-08" version="1">MNTAPLLTRHAVSAVCRSCRRSLLQKKLHHQQRHFTSTPAACGTAFQAYSLPPQPPPSARNASVPSSSIATTPIDAPLPPPSPLRTSQSKSRAAPSPSTLNVSEGEAQQSKKAFAGVEEQGTQQKQTQPTQPNPAPASASASASAQSPTPNKPATRPRSRLRARKAAITLTPAAVERLRALLDQPEPKLIKVGVRNRGCSGLAYHLEYVDGAGAFDETVEQDGVCVLIDSKALFSIIGSEMDWVEDKLSQRFVFRNPNIKEQCGCGESFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL92</accession>
    <name>A0ABR3VL92_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF49">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="139"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="488" mass="53600" checksum="8A1FF8419AE9836F" modified="2025-10-08" version="1">MSDNDLPTALGNLALETAAEADSHTPANPTVPYYSPNIQQAFGSETQPSPLPEAGQAYADIGYAFDEAKYLARSEARLRAGGLPTELPPGWPQALEGPLVWTSSDFPDEDVYIYHLTDQDKAEINDALAHFKTLNKTGRHVNKESFPLPTLGEKLLRIKDDVYEGRGFAVLRGLDVDAYGKVDLVTVYLGLTSYVAEVRGKQNQQGEMLIHVVNTSETIQHENATTNMPYHTDLVCDVVATLTKSCGASGGTPALASVFTVYNELAATRPDLIHVLAEPNWPFDTYHRDPPFYYRALLYHLSNGRIALQFSRRTLVGHAATSPDPTGAARSPGIPGLTEAQAEALDALHAIGLKHEVKVPMQRGDIRFVNNLALMHRRDKYEDGGDDDDVGDGDGGGRRHLMRLWLHNPEACWPLPPALKLAWERVFADQEREERWELLVVEEGTGRLCVKRIWKEGDDDDGEGQEGLCSGENLEPACAAAHPVTACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLD4</accession>
    <name>A0ABR3VLD4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein sec73</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="449"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="747"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="931"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
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            <end position="226"/>
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            <begin position="297"/>
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        <location>
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        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1461" mass="160022" checksum="84DF73AA3C6131A2" modified="2025-10-08" version="1"> </sequence>
</entry>
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            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3VLR8_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">DUF1479-domain-containing protein</fullName>
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        <name evidence="2" type="ORF">VTJ49DRAFT_5013</name>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Drula E."/>
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                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLY3</accession>
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        <recommendedName>
            <fullName evidence="3">Putative zinc-finger domain-containing protein</fullName>
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            <taxon>Dikarya</taxon>
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            <taxon>Mycothermus</taxon>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000033">
        <property type="protein sequence ID" value="KAL1842766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039278">
        <property type="entry name" value="Red1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563:SF3">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="664"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1210" mass="130297" checksum="B5E5E7E68B67D755" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM57</accession>
    <name>A0ABR3VM57_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25996" checksum="62F92D1B12D3D18F" modified="2025-10-08" version="1">MGLNNHGTDEEEQEFLPKPRSTHDANAETDMAATIAYLVAFKPFVVTRDRILRTPVPQFPRKVYTFKPDDRLVNKEMWFNQTLLYHTLHNWVELSSDSRGYVVIPDSDRYDLPTPYDVPIDRHTTGPGYMMSLFHEMHCLTYIVEHFQKGYAGEKLTDDVAYHASHCIEYLLNGIRCCGASTLEGENEFGPGMGQRECVDYEALLEWANAHSAMKWNTGLMPGETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMD2</accession>
    <name>A0ABR3VMD2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_3718</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046027875" description="alpha-1,2-Mannosidase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="581" mass="64578" checksum="EE9312F04D7C01AA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMG0</accession>
    <name>A0ABR3VMG0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="411" mass="44106" checksum="93C2E13E80FC91A9" modified="2025-10-08" version="1">MSTTPDVEPPATTTATPTLTRERNSLTLDQRRALRRWASSQPSTVSHSLSSKYARLDNDTQLSGSRLRFGNWPDVERLVLLWHQQMVNQGKQPSNEELAEKAKIIFTQLPRYKDEEPPEFSPGWIHRFKKRYGLLIRRQRPRRPGHLNNPADDIPYLVDAVNRFMNITPDISPAAIQDVVQRVIGVEPTLHICARVRDEIVRQMDGRQQQGAGAGAGAGAAAGQQPVEPSTPQQQQQHQNGPGPAVPGSADASSLYADEDPEVVLQNALRALQQEEAAAEAAAAAEREARDRADRGLGPAPMTVGGTTYTQQAAAAVSAARATSTGAPATSSSSSATPSNPARFLPAAATPAGQSGTAAGAGAEDLTLTPIPSGAPVSATERPVRCPFCLNQRMLRTIKEAVEHMSTHVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMP5</accession>
    <name>A0ABR3VMP5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vesicular-fusion protein sec17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33546" checksum="171BF613CB75D23F" modified="2025-10-08" version="1">MSLDPRALEEKAKKSLQGASGGWGFFSNKEEKYQNAADYYVQAANAYRLEKLNKEAGQAFEQAAAIHRDKLNEPDDAANLMVDAFKVYRKEYPQDAIRCIKVAIDRYQQKGNFRRAASHLENAAELLEVDLGDRKTAMQFYSDAARWYEEDGARALANKLWLKEADIAALEGDYYRALQNFEKVADSSLENHLMKYSVKDYFFKAGLCILATKDLVSARRNLQRYTEKDPSFAGQREFQLLSDLIEAVEAGNQEAFTDKLYAYDQMSRLDKWKTEILVRIKNQIEEADNEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMR7</accession>
    <name>A0ABR3VMR7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="196" mass="22339" checksum="DE3FF0CEC4EEB3BD" modified="2025-10-08" version="1">MLYVFNKHRVVLPGQSDMESLRIATMLACPGNRYSFAMSGRSRWTSTFSSVLFSCFRLFLIDVMALACGLHAQVVWFACLFMLVLICRCSISCWTESRTGWTTAGFRAGFWRRARILLALRPARQRERGQLKSRHLDGHGSVLMSQGWTNDSVGCWTFHVIVSSSVNLLKVSDRMAINLSFRHSSCQNCCSWFAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNK6</accession>
    <name>A0ABR3VNK6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="829" mass="89221" checksum="B0264B24258E26FF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNY6</accession>
    <name>A0ABR3VNY6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="468" mass="52153" checksum="10CE0FD149EA1BBB" modified="2025-10-08" version="1">MARASSVIPNIQSLYPAGGYLSSLQSLDPRPLEELHNERSYLLYNLQKQNDRATRLFERYASIEARLTEAATPSEAKKCRKEAALIRSKIAESTQQEQLMLLRLSEIQIELQNRDRWMRVHSQPSSYFQPQHPPFVYPPPAPPAPPPSANMSFSSDVLPHPQSNMCEAPAQFQSHNDKNTPTTATTTTHPTCPCPSSSSVLSPLSPCFTPGVCFIEDIWSRASKTPSADKEEAKSWSELAEEEDEEEEEGSRGTGSGFTDEEAIGANENRDGGGVDSAAGDGGDAGGDGNGGELPYQHQNHYQQQRQQKGDRPEEKRHGALPTKPTTNPTYDADSEGRDERDNNNKTGLNKGGEYEEEDMHAWRTRLRRISLFLPVSVRSAGEGEGREEKRMSLPHLKGLWHNGSRRGSAQSTMCYYYTVTFDCQHMTNVKSYCNLRGQRGHRMEFRGSRFQRGPCGDPMCTTPSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP80</accession>
    <name>A0ABR3VP80_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53544" checksum="DF65D1F00C97BF47" modified="2025-10-08" version="1">MCSRHELTASIEAWIDKVIGTEAQATNVIAMPNGLDSSPTASQVGAEVTKAEARGGPRRDKLLYTPDEERAVVRLLDRRLVLFLALLYMLSFLDRSNIGNARIAGMDDDLQSDPPRDDWYEWSLGAFYVTYIAFEWMSLLWRIIPAHIYVSALVLSWGVIASLQAVAVNYPMLITLRALLGIGEAGFTGVPFYLSFFFRRDELAFRTAIFISAAPLATSFASSLAWLILKLASPLPIAPWRLLFLAEGFPSVFAALVAWSRIPDSPDTAPFLTARQKRVARLRLRAPSSEEEDEPRPLQPPPTPLLPKKRGETVRDSLAVLKDPAAWLTAAILFLANMAYASLPVFLPSIVRDMGHGAVEAQALSAPPYLVAFVVVLVTAYASDKMRARSPLLIARYLLLTLSPILNLPPSHPLRYFSLYPATAGFFSVVVLTLAWTVNNQPSSARRGTAFALLQALGQCGPLVGTRLFPERDAPYYARAESSPAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPK4</accession>
    <name>A0ABR3VPK4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32850" checksum="317DF22CD6A56685" modified="2025-10-08" version="1">MLTNYVGVLSLKTPCIPTSLFAIFVSPLVPPDLLPTWWNFGLTGICDNFTETEEVYCRPAFAPSQNVLTVLEDSLRDSLRRRDGQGEDGPEHNENDDESQGDSDPEELLEAVLNSWNDTLASLSPSGLPAHQDKVDTLIYAGAVLTIIAATTDVLGWAFQLVCLPGWTLIPTYLVGGLTGMAAPACVSEAMRASMVGPFGTNDGGFGFHVYLVFVNAGVRLLVCIVMVWFYVAVSPENRRAWLRRPPSSSSDDDSDCYNPPARTSESHPKGTAQSPSQNGPAQPDSGERQRTPDCLGTLEAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPQ0</accession>
    <name>A0ABR3VPQ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="293" mass="32714" checksum="AF8990EAA84AD7CA" modified="2025-10-08" version="1">MSSGDDLYDGEPPTIDPYEVLGVEPTATPDQIKSAYRKAALKTHPDKVPEDKKDEAKENFQQVAFAYAVLSDPIRRKRYDETGSTSEAVVDNDGFNWSDFYRAQYEDAISEEAIKQFAAQYKGSDEERADVLAAYEEHEGDMDGVYAEVMLSNVLDDDERFRAIIDAAIASGEVERFDKYAKETKKTRQARVKAAKKEAQEAEELAKELGVYDKLRGGGKKSKKDTEADLAALIQRNQAKRASALDMLAEKYGAVPKAGKGKKRGAKAMEEPGISEEQFQAIQAEMMKKKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPW8</accession>
    <name>A0ABR3VPW8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="315" mass="36212" checksum="A8F8FA3B13AEC823" modified="2025-10-08" version="1">MMSQNINLLRGSLRLGQRFSKPSFLTELIEAAFAPIWEEYYGAYCEIFEPDTPVPGNYEFQGDILACPWLTADLMISAQQKWYRRNGGPGWWARKQAEASAEVLPRPSVAEGADAVATLFEDSWTTFRDRCASAVTSSSLGEDEVRSLVGLALFPDDDFLIEVHPSAPLPHRLFFPPFDWEKAKMLFWLARAGKKMRENWMWELSLNSYHEILKVEDPHLALVMFLLLARMGAFQTLVNWNLEPEMENLNQLLEHPKGPAHPTLWRHVRPLAQRRASMYCRECRYSLPSVAWMYIGTHRKMPEEETLSSVSQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ05</accession>
    <name>A0ABR3VQ05_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19115">
        <property type="entry name" value="AKR_AKR2D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044487">
        <property type="entry name" value="AKR2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="321" mass="36328" checksum="52520B42F267A53D" modified="2025-10-08" version="1">MAPVIKLNSGYDMPQVGFGLWKVDNAVAADVVYNAIKAGYRLFDGACDYGNEVECGKGVARAIQEGIVKREELFIVSKLWNTFHDGDRVEPIVRKQLADWGIDYFDLYLIHFPVALEYVDPSVRYPPGWHYQGDEIRPGKATIQETWTAMESLVDKGLAKSIGISNFQAQLIYDLLRYARIRPATLQIEHHPYLVQQELLNLAKREGIAVTAYSSFGPASFLEFNMKHAVSLTPLIENDTIKAIAAKYNRTPSQVLLRWATQRGLAIIPKTTRTELMVSNLQSVDFDLSEEDIATITGFDRNLRFNQPSNYFPTDLLWIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ84</accession>
    <name>A0ABR3VQ84_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="85" mass="9149" checksum="0102DBCE66C67BCF" modified="2025-10-08" version="1">MGAVVSCIQSALRAIGRTIMSVLYGIGNIITAIVNGIVDFFGVIVGCLTCSGSSRRRRVGHHHTTGTTTTRRRGWGRKRHGVRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQG6</accession>
    <name>A0ABR3VQG6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="218" mass="21923" checksum="DA4544800AE5A653" modified="2025-10-08" version="1">MPPIPVYTKSPINPAKASGVTPETAAPADSKEQPSYVPAQTTSSPIQPYLNDSRSLTPTRTVPLHGQSPPPPQPGAVPRLPEATGAPSSSSSSSSPAAPTATGPPPPAITAAPVYPPPPPQLGIPPPQVAHNQRGTSTAPPRPPTGATSTYHSGQYGGGGSYPSPYQGVGGVGRGVGGQQEEEDEGILGSAVKLAKAAGQKLASAESEVWRRINGDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQK5</accession>
    <name>A0ABR3VQK5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Tim10-like" evidence="10">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="122" mass="13250" checksum="D081AC794E89982B" modified="2025-10-08" version="1">MSNSNLTDADLAKLNDKDKAEIAQFLAHEQQRGRVQSQTHALTSLCWKKCIAPSAPHASSSSSSSTSSSTTSGIRGFFGGSRSTVSNDLDSTEKQCLANCVDRFMDANYATMQHLKTLQNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQN4</accession>
    <name>A0ABR3VQN4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane adaptor Erv26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24660" checksum="563CC039A917E017" modified="2025-10-08" version="1">MWILPLVGYLGSVVGFCFMTLAIASGLYYLSELVEEHTVMAKRFLTKLIYSIMALQLLLCLIDRFPFFPTALGIFSHFIYLGNMRRFPFVKLSDPLFLTSCVLVLLNHYVWFKHFSSHQERAYQNMSTYYDTPSDIPSFSQIASYFGLCVWLVPFSLFVSLSASDNVLPTMGSEPSSSPSMDVGGKRKNQGMAKALVDTIRGTIAQGSAMLGGKKPEDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQP4</accession>
    <name>A0ABR3VQP4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 15 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="397"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1844224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="551" mass="59670" checksum="6550E8E9DE31EB27" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRA3</accession>
    <name>A0ABR3VRA3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042776">
        <property type="entry name" value="Ribosomal_mL53_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L44, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="98" mass="11038" checksum="7F562D6702CC296A" modified="2025-10-08" version="1">MITRFITDVTTRFNPFSPQARSARLFLSFLPPNARSSGMNITTQLLPRHSADPPTLYVKFKDGKEMNIDCAKTNIKDIVGEVDRHSRMLQKNADLADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRD9</accession>
    <name>A0ABR3VRD9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_3836</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF3">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045201993" description="Endo-1,4-beta-xylanase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="16">
        <location>
            <begin position="32"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1844180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="287" mass="30452" checksum="84A10B174447A180" modified="2025-10-08" version="1">MVTFSSLFLAASAAVTALAAPGELPGLHKRQTLTSSATGTHDGYYFSFWTDGGPNVRYTNEAGGQYSVTWSGNGNWVGGKGWNPGAARTINYTGTYQPNGNSYLAIYGWTRNPLVEYYVVENFGTYDPSTGAQRLGSINVDGSTYNIYRTRRTNAPSIEGTRSFDQYWSVRVNKRTGGSVDMNAHFNAWRQSGLQLGTHDYQIVATEGYFSSGSARINVGGSAPSNPGGNPGGNPGGNPGGNPGGQPGGGNCSPRWGQCGGQGWNGPTCCQDGATCRAQNQWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRE0</accession>
    <name>A0ABR3VRE0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 7"/>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05292">
        <property type="entry name" value="LDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000824">
        <property type="entry name" value="PRK00066.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="151"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="336" mass="36462" checksum="BC1781C653978027" modified="2025-10-08" version="1">MPDSKRPNKAIKVVIVGAGSVGVTTAYALLLDGLASDIVLIDIDRNRALGEVMDLSHAAHLHKARVRVGDYEDCENAAAVIITAGVNQKPGQTRLDLVKTNYALFRDVVPRVAHHAPDTIIVVATNPVDVLTHAAYKLSGFPRERVIGSGTAMDTTRFRHELGKHFGVNPRNVHAVIVGEHGDSQLAVWSLATISGMRLRDYCTAAGIEYDEKALEACATRTKEAAYEIIRRKGKTNYGVASVLVSVLQPIVTDSDAIMTVSRVGSYAGVEDVALSMPCKLNRHGAYQDVPLLLSEEEREALRRSAQSIKDVITSLEEHLKPAEEKAEATEKPEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRP2</accession>
    <name>A0ABR3VRP2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein phosphatase methylesterase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046381992" description="Protein phosphatase methylesterase-1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="11">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="10">
        <location>
            <begin position="33"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="841"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="959"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1067"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1844306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1312" mass="139713" checksum="DE5D11B58479BAFE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRV2</accession>
    <name>A0ABR3VRV2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_55</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="56"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="230"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="416"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="811"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1844376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124855" checksum="F5C400C3FDAB18BE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0K4</accession>
    <name>A0ABR3V0K4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000729">
        <property type="protein sequence ID" value="KAL1835333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="267" mass="27376" checksum="BFDA93B6CCA606F6" modified="2025-10-08" version="1">MSYYGCGSKQTLYTIFSTPWGGTSTSTTITDSSTTTTTNIPATSTSQTTTSQTTSTSPAATNDSNSSSSSTPVDAIVGGVVGGVVALELIATGIIWMNLRSRRNSNGGNGGNAATTTDPAWTPIAPQMTGYATSAGGSNPPPTFDPRMSMAQSSAGMTSGYFGPGAIGATPPPQPGMQSMYAPVPPASPPIDDPNASMLYYNDPTTFQQQPASQPPAFVSELDTNEPVVRGYHGTPVEGARSSPQPQGMGSAFSQTQWTGSPPQQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V148</accession>
    <name>A0ABR3V148_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zonadhesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000666">
        <property type="protein sequence ID" value="KAL1835434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1196"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1317" mass="140169" checksum="4BF2E96894B16F99" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1B0</accession>
    <name>A0ABR3V1B0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000630">
        <property type="protein sequence ID" value="KAL1835507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="69351" checksum="E20734683356DFD4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1B6</accession>
    <name>A0ABR3V1B6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000607">
        <property type="protein sequence ID" value="KAL1835557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="581" mass="64572" checksum="24496CD62FD9843E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1I4</accession>
    <name>A0ABR3V1I4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000598">
        <property type="protein sequence ID" value="KAL1835582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34410">
        <property type="entry name" value="INTRON-ENCODED HOMING ENDONUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34410:SF2">
        <property type="entry name" value="RRNA INTRON-ENCODED HOMING ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="125" mass="13983" checksum="6F2866FB063FECA1" modified="2025-10-08" version="1">MINRDSRGHQYSIVRGTKVRGSKTIRYRRSLNHKLCRLGIGRRYFLTRSAPYDKSKCLGSWGSMVARLKLKEIDGRAPPGLFLDFVGGGAWPFLVGGVICLLNCDNERDLNLLNSPYCFGSTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1K8</accession>
    <name>A0ABR3V1K8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000720">
        <property type="protein sequence ID" value="KAL1835346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="380" mass="40996" checksum="516CA8894E745130" modified="2025-10-08" version="1">MRKAEFGSSQKGVGTSPRGCYKSPKDSSLVSRNGNEVIIMTAVDIDSRSNVRLPGREHIPIYPKGWIGIRIAQGVLALIVLGLAANGVSNFAIGVDSVNLILAMGVLTMLATIWHVVYEFALPAAFNYWAVLALDIFFTVLWLIAFPLVLADVAPAFSGSNWSWYSSSQKTILGTVLAAGAFGAVEFILFVACLIVGGIRLHRHRKAGLHCMPAKAVAAVPMTTAAPQPQQQFAAPTYPAQQPQQQPQQPQPQAYPPQPQGYPPQGQQPVYAAPQGGYYVPVPPSSPQPQGMVSPPPPQGFYSPTPPPQMVPQPTGNTVSSSGFGSTVQQQQQQQQQQHYPHHHQQQQQQPVQLPTSNSPQATHAELAASYPPPQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="536" mass="57741" checksum="B27FB785937C8E08" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Schmutz J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
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</entry>
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    <accession>A0ABR3V257</accession>
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    </gene>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Haridas S."/>
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                <person name="Grimwood J."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000520">
        <property type="protein sequence ID" value="KAL1835868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF319">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="242"/>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000471">
        <property type="protein sequence ID" value="KAL1836068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="223"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="651"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="860" mass="93030" checksum="D14465B106AAC5C5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2X5</accession>
    <name>A0ABR3V2X5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000469">
        <property type="protein sequence ID" value="KAL1836075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="776"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="824"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="969"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="932"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1003"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1087" mass="118465" checksum="817BF736A8114367" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2Z2</accession>
    <name>A0ABR3V2Z2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000466">
        <property type="protein sequence ID" value="KAL1836091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045990851" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="144"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="845" mass="88864" checksum="B5E9DF67647EBD78" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V318</accession>
    <name>A0ABR3V318_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000453">
        <property type="protein sequence ID" value="KAL1836172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41989" checksum="520DC25E6E273FF8" modified="2025-10-08" version="1">MAHMTNPLATPDQLFQRRSLGALPMELQDMIFFSTQCLTQAAGLLLQLPQSVTAQANVLLARYWLVENMMAHEFSVRFSSSGLSLSPNDEPKKLNGVVLQDVSAATLYLVAKLSSHPVSPRDVAYIYTYLLSSCSAFFHDPSSPPPPPPPPPFGPETTTTTTTTSTPSPSEKNTITPYLSPAAYQSFHARLLHLEGLILAALGFDTHVALPHPLAITYLQALDFFSFHKDGGGSKEAGKKALAARTVAYLNTALLSPQVLYLTHQPPALAVAAVYSAARDVGAKMPECEWWEVFDVEREELGFLVVGMRSVEGWGRKMRGDMKEVMGGRERGMLMRKDVEGELKRRGLMIVGDEVQNGSKMMVDAEEEAAKRLDEKMAEMESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V329</accession>
    <name>A0ABR3V329_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-xylanase</fullName>
            <ecNumber evidence="11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5469</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000450">
        <property type="protein sequence ID" value="KAL1836188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047483376" description="Beta-xylanase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="35"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1836188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="363" mass="40989" checksum="831EFC55A73302F0" modified="2025-10-08" version="1">MRFFTSLFLALSGSVAASPVHVDNEAIELFNRQIQSLNAAMIAAGREYIGTSLTVRNDQQEMNIIRSEFGSITPENAQKWDATEPNRGQFTFAASDQHMNWAQQNGIRHVRCHTLVWYSQLPWWVSNSGFNNATLIQVMTNHINTVMGRYRGRCTHWDVVNEALNEDGTYRDNVFLRVIGEAYIPIAFRIAAAADPAAKLYYNDYNLEYLGPKVEGAARIVRLCQQYGVRIDGVGYQAHLVTESTPTQSTPTPSEEDLTKALRITADLGVDVAYTEIDIRMRTPSNYQKLQDLANAYARVARSCMNVKRCVGMTIWGVTDRYSWVPNTFPGEGDALLWNSNYQRKEAYNSFLRAIQAPVNATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V337</accession>
    <name>A0ABR3V337_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_5694</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000483">
        <property type="protein sequence ID" value="KAL1836012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="277"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1836012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="579" mass="64225" checksum="9C86DD7D3B7EF570" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V406</accession>
    <name>A0ABR3V406_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000401">
        <property type="protein sequence ID" value="KAL1836513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047404534" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="62"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="486" mass="50905" checksum="1D8A9DD53B00DA6C" modified="2025-10-08" version="1">MLLADASLLSLALAPGASGLVARSDGIVRAAVRAIPDPDPAPNLRSRQNVIDVINQRNGTRYAVEVALGTPPQTQYLILDTGSPDTWFNPTCETSRVVAECRQYPRFDLSKSSSLRDLGVSDLLLYGSGQAEINWYTDTFTIGSATIKNQVIGINVASERIPLGILGVSPPVGGVNEYPYVLDSMVSQGLIKSRAFSLDLRGVHNPNGAIIFGGIDTGKYIGSFAKLPILPQSQSPRGGNRYYVTMSGIGLTLPDGTVVKSGELSTPVFLDSGATLSHLPTRIFEALASSFDGAAYEPETGYYYLPCSATNLNGTIDFYFGDKAIRVALNDFIWQVGPYCLLGAVAEEREPILGATFLRAAYVVFDQDQRNLHIAQAANCGENLVAIGSGKDAVPSRTGDCTELPTPTGTNASSSRLDVTKTHAPTATFTGPVPTLDDGPGPAADHTATGTLPLGTDDAGNAAGKGVQLSLGVAAAVAAANLVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V455</accession>
    <name>A0ABR3V455_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GS catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000452">
        <property type="protein sequence ID" value="KAL1836176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF2">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="315" mass="34633" checksum="ECA42C2735FA1D41" modified="2025-10-08" version="1">MGRLLGRLADSGHHESTLLMGFEIEFVLLNESLDIARSPLDRTNAYSMTTGLSVLEEIVATLEDVSGIQVYHFHTEIKDQLEIALSPLPPMQAIDTVMMAQETIRALALSHGLKASISPRAVLGGPLSGVHAHMSVKSESLGLHFLAGVLKKVKPLRAFGLATYDSYLRAVGDAAGEWVGWETRNKDLPINQISEPRWELRFLDGTANIYLFIAALLVAGIDGVRQGYPRESSDCNVAIPPSLGPGALGEWLGKYGITKRMPATLRDALDAAREDTELQGWVGPEPWARYLKVKETEVATFSKMTDEERRQKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V495</accession>
    <name>A0ABR3V495_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000437">
        <property type="protein sequence ID" value="KAL1836276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="788" mass="83506" checksum="C6E4FC3925F9E3CB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V519</accession>
    <name>A0ABR3V519_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000418">
        <property type="protein sequence ID" value="KAL1836388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045563675" evidence="3">
        <location>
            <begin position="23"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="125"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="434"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="582" mass="63119" checksum="98D9C01419859DD3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V598</accession>
    <name>A0ABR3V598_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000365">
        <property type="protein sequence ID" value="KAL1836800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="148"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42918" checksum="8DFB2B06CC2B929B" modified="2025-10-08" version="1">MSSTASTNRIRVGLIGLSSGAKTAWASRAHLPYLLSPRGRSKYEIVALLNSSVTAAESAIKTYGLPQESTKAYGDPSSLAADPNVDLVVCSTRVDKHYETVLDSIRAGKDVFVEWPLAHDEKHARELADLAAKSNVSTIVGLQGVVAPVAKKVRELLEQQRIGKVLSSELRAFGGLNDRQVVPDGLVYFTDRGIGGNIYTIGFAHTLDLVLSVLGELATVSGDFHLQRPENTVKTAAGETSTVKSDVPDLIQLSGRWNESNITQKNATLHYRYRRGQPFPGEPAFEWTINGEKGELRIISQNNTHIQVGDSSTSRVIEIHDFEADDVEKIEWGWEDWQQDLPFPARGIGKLYDAFAEAKRTGEEGHYATFKHAAKRHEQLETLWAKWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5P3</accession>
    <name>A0ABR3V5P3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000332">
        <property type="protein sequence ID" value="KAL1837073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="90"/>
        </location>
    </feature>
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            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="293" mass="31543" checksum="34F0F281E694D65A" modified="2025-10-08" version="1">MGRYRKTQSRQRGGHFQGGSQAARTERMGNPSHGLVQWSQSGSQTVSHIPQGRSQRATFENTHQASASRTSKKRKRQQPSSGPPAASQQSVLGPNVTTSTNVNQAEAAASHVPTTPTMAPAAPAPSGTAEAAPMRNEPDPRVNALLAQIRTVMNVSPPQEARTHIDTARAFLQGLAMGAGMVMPASSSAEATRRRIDRRSRSPSRHIHPRRSQSPRASWCVSDCGQHRHEQQAGCTHRERSPLGRPGQHRQGHQPKTANAARDAAVEGVGPRFGSISPQGTNGSVEWVRRPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Q0</accession>
    <name>A0ABR3V5Q0_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000331">
        <property type="protein sequence ID" value="KAL1837087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="536" mass="59147" checksum="98468AF0112FAAF1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V602</accession>
    <name>A0ABR3V602_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000321">
        <property type="protein sequence ID" value="KAL1837178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="518" mass="59018" checksum="E6B72D6FCDABBEE5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6F6</accession>
    <name>A0ABR3V6F6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_3991</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000307">
        <property type="protein sequence ID" value="KAL1837320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23134">
        <property type="entry name" value="RING-HC_ITT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="186"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="190"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="558"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1837320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="684" mass="73646" checksum="7DE5C3A2491E0CA6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6L3</accession>
    <name>A0ABR3V6L3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_3930</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000299">
        <property type="protein sequence ID" value="KAL1837390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="28"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="342"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="804"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="892"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="956"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="901"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="962"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1837390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="992" mass="108430" checksum="A482C99785B225B2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Y8</accession>
    <name>A0ABR3V6Y8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Murein transglycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_3729</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000288">
        <property type="protein sequence ID" value="KAL1837501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39798" checksum="1C1B5976048FD727" modified="2025-10-08" version="1">MGSTKPTFTAPPPSVVTSVGNAEHGGQFFEVETSSAAPTTTEAPKPKENKPPADDGPKGLDADFPSGKIKCDRVPTEYGPVEIPWSTTNGWTTLQNMHKWIKGVAFDNFEQPVDGTCRPGMFCSYACPPGYQKTQWPEEQGATGQSVGGLWCNDDGFLELTRPSHPKLCEPGAGGVFVRNEMSTNAAVCRTDYPANENMIIPVDTQPGGTYPLTNPDQRTYYKWKGMPTSAQYYVNPKGIPVEEACIWKSEKHGPKVGNWAPVNIGVGKAADGITYISIFPNKPTTDALLDFDIEIEGDINDECWLKNNVYYRGNPNGCTVRFDRIKSCSVSAQLGYANANADWYEGRRQGHHCLQEQVLDDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7J9</accession>
    <name>A0ABR3V7J9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ornithine aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3931</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000299">
        <property type="protein sequence ID" value="KAL1837391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="492" mass="53215" checksum="7DC8F80BC29D38BC" modified="2025-10-08" version="1">MAPHADKDASSSGELSKDRYHAASTKGAIAAEHEYAAHNYHPLPVVFARAQGVHVWDPEGNHYLDFLSAYSAVNQGHCHPELVKALTEQASRLTLSSRAFHNDVFPVWAEKMRRMFGYDMVLPMNTGAEAVETAIKIARKWAYKVKGVSPGKALVFSAAGNFHGRTMTAISLSLDPESRDNYSPFLPNLGATNPTTGRPIRYNSIPDLEAVLSTHGPDTAAFIVEPIQGEAGVIVPDDDYLARAHELCKKHNVLLICDEIQTGIARTGKMLCSEWAGVRPDMVTLGKAVSGGMYPVSCVLADRGVMGVIEPGTHGSTYGGNPLGCAVSIRALELVEEEGLVGKAERLGEIFREGVRGFKSPIVKEVRGKGLLNAVEIDESKTQGRTAWELCLLLKEKGVLAKPTHGNIIRFAPPLVITEEELRKAVEVIGEALKELPTASCLTKSDAPMPAAVRLRHLRDVNPAGNMAGRNSVLVSPHVIWVVDFSVSVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7L9</accession>
    <name>A0ABR3V7L9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein rds1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000332">
        <property type="protein sequence ID" value="KAL1837078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046774120" description="Protein rds1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="51501" checksum="580CE0DD7187DE57" modified="2025-10-08" version="1">MRHYLALELAIVTAFTGVTAAPVVSTPTTTVFSEPTGLPSPYAISHHNVTTHGPYTVPATTTGAISTDILAPSIAPAPPPPQIVEYPADGKLHGAQPMPYTPSGGIGTNGSLPIYKVATDFDYQSIALALYHEWIELDLFHWGLATFSEEDFDKYGIGAEDRFLLQHMADQEIGHASVLANMLGPSAPKQCTYNYPVSNVREYIDFNQKLTRWAEAGVYGFLPHLNSGPAAQMLLQSITVEARQQMVFRQFGGMFPMPEWHTPGIPQSWAWTLLAPYIASCPENQTRLIWQNFPSLYILNQPNPARINGADVWGETTTGWSNTLSTKDIPEDELCINSDETGVNCEAAISRNRSLPLSYPGREVFLRWDPPGHLVGPNSSYVTTTNVQEPRFALWLSQLNVTYTPLLNVSLEDRTAYTIQPNVSTWLNDPAVNGTMFLAITDEDLFVTPYNVTMVNPHVAALAVYQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7R2</accession>
    <name>A0ABR3V7R2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000259">
        <property type="protein sequence ID" value="KAL1837833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="503" mass="54994" checksum="31E9B69F1A6FFA11" modified="2025-10-08" version="1">MSLFSAQLHPGRALGFLVLGASLHDVLTRLKAEPQRFPKINLTYNPQDPIQTQIHIGLPANGLRLRFDGPEQRLRLIEVIDFSKIHVFLKPANDKERDLVRPQAASDGTAGPTFRHIYQRFLGPTYDGEYLAADKTYLLSYPGVAFSFPMKPDEYVAGKDVVSLLPATAVPSSMAVFSGESWAAARGTLWTEVLPSVRLFPPLAKGKDTSPDEVSLIRIHGGGKLQLVRRWSGASFWITLGETTPQQLVAELGPPDAIYRKNDQRMYIHKLRATSTSTGARPTDLRRPDDLTDTDQSSSHPASDADDTNDEAIEDDDAGSSMSRECFYNYFYLGFDVLVSPPTEPSRPPPPADGTTPPPDTPAVRGTPPDREVATKLVVHGNVPGSYPFNRYRRCRWEISYLPGGATSETPFPEVEERLRAAWAPAYGSAAEAQQSQRGMVLNRGWGDSPGSSCELLGGWEGDAGSAGNVKGRGEDTTTTLYGFPGLVFEVLKTGWVSAVTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7S9</accession>
    <name>A0ABR3V7S9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000261">
        <property type="protein sequence ID" value="KAL1837814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="456"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="538" mass="59782" checksum="F70A530446FB6BED" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8P4</accession>
    <name>A0ABR3V8P4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TFIID subunit TAF5 NTD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2978</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000234">
        <property type="protein sequence ID" value="KAL1838152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="87"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="532"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="576"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="706"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="770" mass="83757" checksum="E50303CF5F7B3F6F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8W2</accession>
    <name>A0ABR3V8W2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000246">
        <property type="protein sequence ID" value="KAL1837992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF208">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045477664" description="alpha-amylase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="13">
        <location>
            <begin position="34"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1837992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="592" mass="64907" checksum="8EA51189CE5AEF4B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Q3</accession>
    <name>A0ABR3V9Q3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000258">
        <property type="protein sequence ID" value="KAL1837843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="434" mass="47368" checksum="A7019FEB8C95E5CB" modified="2025-10-08" version="1">MSNPNIGKVPTTDPLLLPISASDLLLEAGLLSKVRPGRPDSQSTAKFRSGDGDEGGLNREAPEEEEEEEEEEDPVSAIRMGCPELDEHVLLGGMGKGEVVGMALQTMAHLLATDPLARAMVVTTLPASALLPSLRTALLVRLSSTCLENRHHVHVRVIACLKRIDISRVFDVEGLLEVLGELDGDSTVAPPRTETGQEMPAEHVSEDRKERQPPPPPPLPPPPEQKRQQRTEVRDSEDESSLSSSPLSSPPASPLLEEPQEQPQPTRQIPTPMQREPAENTSRLPDLILVTHTSTLLNALFTTRDKPAAHDTMVRLAACLRALVRPPSFGQVFSKLLDLHLLCTRTGAAAAAPGVRWAVEVLKDEVGVYEYGNEEEDERAAGADGGGRNNESNDISRRHNNRRIRRRCREKRWGVVDVVVGGRVVNAEGLEGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Y1</accession>
    <name>A0ABR3V9Y1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000228">
        <property type="protein sequence ID" value="KAL1838241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="338"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="397" mass="44246" checksum="760A3D1BB0FE37F4" modified="2025-10-08" version="1">MQAPPPQGPQGPQGPQGPMGPMPGQMPSPEQIAAMQRQLAIDAEKHGMTVPQFIEHLKRQAMEQMRQAQQQAQAQGQGGHQHPHGHQHPHPHPHPHPHQHPAGQPQPIVPGPPNPVAIALAKFLRSQNLKPRTCILNGERKDMFRVKRALRALESDAYKAARKKNPALPEITDRASLENAFKLLPLSMLALRVVKIDPHEGHDHGPKKQGKRVKGLWTVRIEPQQEAGDDMYYVWLWEGSQVMRKVYAALAILVIFALVCYPLWPASLRLGGYYLSWGFLCFMGLFFAMAIFRVILFCVTYFVLPPGFWLFPNLWEDVSVIDSFKPVWAWHEPASKKKKKKSKKSTGSANAGATFSATTGQPAPATATTTATDTKVATVPQPRTYMGPRVEEVEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA37</accession>
    <name>A0ABR3VA37_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000203">
        <property type="protein sequence ID" value="KAL1838633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="431" mass="45926" checksum="722D4A2C828A89E3" modified="2025-10-08" version="1">MSDILDDALREQLAAALLGWGGDPGELRFSLDTVRSSTGDVQNHNASINKALPPPPATEARRPSQGRIGSLLDLEDEVNAHAVTVVDDIDADSITVDGSTDDMTDHGAVFSWTAWPGTGGSGGSHGGVGELQSQSPSQWQQPRSVNAGAPHPDHGKALPPRPVDSTIPASPPPPQMFCRLSRFPFSHPCDVPELMPDNDEDMSAAATTSAPSAPVTPGVTHDALGPAATQATLVAATPGPQLNPTLLPEHDERMRKLSIKTVDTVTSVNEDGVSLLTPTEASYEGSGDHASHALRTITTARSDVRSVSSLGSYGSSERQPSRAARKSISLFSRIRSNGHPEEEPLERRVLTPVQLLTPPQQHADLDDDARAPDTSASLSPFSSTTSRAESGMAYKFFRMPWAREYTRRTHENPHIAQGSEYLVSDLPACRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAW8</accession>
    <name>A0ABR3VAW8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="205" mass="24166" checksum="D7180575653E95C9" modified="2025-10-08" version="1">MSTTSHFADVSADYEAILAEISRLAVTEEKRGHEQSKAIADFQRRSKEFALSKNRRREEALQNKTRLEQEFMRDVLRQFQAYYLECKRQEGNYLDDLERHEHESPEDLQRRMQEHQEDRDHRRNEIDLAWKRRKDELNQDRECLRQHYLLGAQRDSSKFIVSGIIAMLERQKEAFEPGPAEVDNALSTSLAALMRLQGALDESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAX7</accession>
    <name>A0ABR3VAX7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000223">
        <property type="protein sequence ID" value="KAL1838308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="313"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="519"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="683" mass="82118" checksum="861120115DE8D031" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBU1</accession>
    <name>A0ABR3VBU1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000166">
        <property type="protein sequence ID" value="KAL1839285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01466">
        <property type="entry name" value="vWA_C3HC4_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="595"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="967"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1133" mass="124196" checksum="B3769E92DE2A4981" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBV1</accession>
    <name>A0ABR3VBV1_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000164">
        <property type="protein sequence ID" value="KAL1839324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
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        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="119" mass="12886" checksum="DABB878FFFE6E9AA" modified="2025-10-08" version="1">MARSEEAEAFFHAVYSAVQEIPPGRVTSYGHIAKLIGTHPSHRFHSANVPWQRVINSRGIISPRGSHPGGAQNQAAALRAEGVVVTTGPLGELMVDLDEYGWFPEVLPSEEGLLDEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCD1</accession>
    <name>A0ABR3VCD1_HUMIN</name>
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        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000155">
        <property type="protein sequence ID" value="KAL1839465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046695847" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="37"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="143"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="248"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="342" mass="35906" checksum="92EFBBDE78E70BF7" modified="2025-10-08" version="1">MASSGLRTAVSLVALAAAAQALPRTAVSPVVKRQQEAHTRLGCFVDNANNVRLLGGASTASDDMTVAACASFCSSFQYFGLEYGRECWCANSLSASPVDDADCSFPCAGNSAEKCGAGDRLDVYLNDEYAPPTGVPSPATLADFEYLGCFTDSGNNRVLRGIATFDSAMTLEKCAEICSAYSFFGVEYGSQCFCGVDLDDSSEEVPQAECSMPCGGDPTNVCGAANRLNLFVSTSCKEDPTNLPTVGAFAYQSCWTDNVNGVRSLDGPVLRGNDMTVEKCADFCAGYEYFGVQYASECFCGNQLGGEAAPEDECSHICGGDASQWCGAADRLNVYAAEPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCE3</accession>
    <name>A0ABR3VCE3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="287" mass="31490" checksum="0C04D792959F5295" modified="2025-10-08" version="1">MATADPFDSALDLLRRLNPKHTAEHLNNIMTLAPDLTEDLLSSVDQPLAVRRCKQTGRDYLLCDYNRDGDSYRSPWSNQFDPPLDEAGAGVGGVGPGGANEGAGEGAVPGERVRKMEIKANEAFDVYRELYYEGGVSSVYLWNLDDGFAGVVLLKKASPPNDGSSSGVWDSIHVFEASERGRTSNYRLTSTVILTLATRGAALGEVDLSGNMTRQVEQDLPVENDDSHIANIGRLVEDMELKMRNLLQEVYFGKAKDVVGDLRSVGSLSEGQRDRETHRELIGSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCH4</accession>
    <name>A0ABR3VCH4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrodipicolinate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000169">
        <property type="protein sequence ID" value="KAL1839207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF68">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="33589" checksum="FD09FB706FFAFA64" modified="2025-10-08" version="1">MPATSSPDNLQPAIDIDMQVKHSIFLACAGITGIALLGSTGEVVHMSSEERRSMVAAVRGALHCAGFNDYPLMAGMMTNGDLNEVLASLNHYASAGAQWGLVLAPGYFGPEVRQEGLVAWFTAVADRSPIPILVYNYPGVNNGLKILPGTYRKLAKHPKIVGCKMSHANVSRHVQVSLDPEIDHDKFRVYSGFANHLGPIVAFGAAGVIAGMAAVYPKTVVRLMNLMLKEEPTPEERVEIHRLQFAVSQGEEFVMRYGVLGIKEACFRVAGFGNVEGGRLPLRGQLPNGAWEMARSRFLMEIDEAEASLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCH9</accession>
    <name>A0ABR3VCH9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LrgB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000159">
        <property type="protein sequence ID" value="KAL1839407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249:SF0">
        <property type="entry name" value="PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PUTATIVE SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="55406" checksum="4C697C821CEB3EAA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCS2</accession>
    <name>A0ABR3VCS2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000181">
        <property type="protein sequence ID" value="KAL1838998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="944" mass="106843" checksum="7C83A2F1EB6E793F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD86</accession>
    <name>A0ABR3VD86_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="264"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="786" mass="84265" checksum="62E076D60E3836A7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDN5</accession>
    <name>A0ABR3VDN5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047325815" evidence="8">
        <location>
            <begin position="16"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="137"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="387" mass="40658" checksum="D01E595FD9887D14" modified="2025-10-08" version="1">MQLFTLAALLPFVLAAPVIQKPGAQLVPDQFIVKLKDGASERALQDALRHVKAGNLKHSYRNTRFKGFAAKLTREALDAVRNLPEVEYIEQDAVVRTNAIVTQENVPWGLARISHRETLATSYVYDDSTGEDTCSYIVDTGIYVDHNDFEGRAEWLTNTIDTDDTDGNGHGTHVAGTVGGVTYGVAKKTRLFSVKVLNAWGSGTWASVIAGIDFVAADAANRTAAGECKKGTVANMSLGGYKNDAVNAAVAAAVKSGVVFVVAAGNSADDSEWYSPASEPTAITVGASDFTDTVAWFSNYGAPVDIFAPGVNVLSAWIGGKDATNAIDGTSMASPHVAGLAAYLLGLYGPKTPAEISDIIRNTSTTGVLSGLQTGTFNGVAFNGVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDQ6</accession>
    <name>A0ABR3VDQ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000152">
        <property type="protein sequence ID" value="KAL1839531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="14"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="328" mass="35992" checksum="D18C91FC147A8523" modified="2025-10-08" version="1">MAQKFEQLPEELQLATSAHVKYIQSLDTRKDEYGYWLTEHLRLNGLYWGLTALHLLGHPDALPRNETIDFVLSCQHDSGGFGAAPGHDAHMLSTVSAVQILATVDALDELDTRGKGRLQVGKFIANLQNSETGTFAGDEWGEEDTRFLYGAFNALSLLGLLHLIDVDKAVDHIAACANFDGGYGVSPGAESHAGQIFTCVAALTIAGRQDLINKERLGRWLSERQVAGGGLNGRPEKKEDVCYSWWVLSSLEMIGKTHWIDRDRLAAFILRCQDTENGGISDRPGDMVDVWHTVFGIAGLSLLKYPGLEAVDEVYCMPKAVTARVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDT7</accession>
    <name>A0ABR3VDT7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000165">
        <property type="protein sequence ID" value="KAL1839296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="227" mass="23543" checksum="34D7646978423A76" modified="2025-10-08" version="1">MAPRTNPTKTSDAAPTATTTTVKKFELPALNLEFGSLTDGTDIPPPLPSPVKEEAVPTPPETPADQQKAKQANGGTNGAAKAGTTSPQSEAASDTSAAGTKRRAEDTPASPTLSSRPGSIRRLFSRGLLNAAYANGDDASSLASPTERPRSRGGNSTAGSRKAKRASGWFGRLRGVNDSAPLSPPATDDKKPTGPPPPMIPELSELNQKLGIENDVSFGNDLFKDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDT8</accession>
    <name>A0ABR3VDT8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="157" mass="16723" checksum="AB702D360DEC8234" modified="2025-10-08" version="1">MMLPKRTLLLPRAAATRCLSTSAVRPFAMPASSRGSQQQQPSSSQTPVDDIDLVFDYPTEGQASHQKRRLEESGLDLHSAMPHGPKGVPGKSAGKEMGAADSNAMYKYIGVGALGLGGLYMMMRRQSAGPVLTQSNELGATRPGEGSSMQRVFGKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE21</accession>
    <name>A0ABR3VE21_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000128">
        <property type="protein sequence ID" value="KAL1840089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="224" mass="24454" checksum="CE0BCAD1B75F024B" modified="2025-10-08" version="1">MDSRTGSSILSPATQDSDEQMNRRVFLDELQNGLDCVQGSGSFAAFETTGSDSRWRAETIVDTSVRNTWEMDAAKIRFDQRWDDDVLQLCINFVEESLGIQASIRAEPYKMLIYEKGAMFKGSSCCHPASSHMKASRPSLQKSPSGCSILTESNRLRRALRIRSLIDIIIADKDDNGRAEPGLTYNTTLTTTPSSSGGPRRPALPSFCSGAPQVGGEVVRGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE77</accession>
    <name>A0ABR3VE77_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000151">
        <property type="protein sequence ID" value="KAL1839553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="395" mass="45024" checksum="7C71C40AE186F1F6" modified="2025-10-08" version="1">MISSVVNPPVSTWPLTNAEEANLFRHFVSRLAMWLDLCDPNHTFEIVVPQRARESPVLLKAMFALAARHLGQTRPPGQLKNSYNQLADMYNEACINIMKSILGSNNYEPAWTENLFAATIILQVMEEMNAGLSDGNDDGGADQDKKEALHRGHLPGMYRFVRERSFEPGTLGAASFWVGLRQEIYSAVTKKQPVCLNLVHPGLVDRSLTETDDYAWANLAVVHCADVLNFCFGSERQQQHRREELDAFNRKWSDKQPRSYDPVFREPKEAGIFPEIWYHRSCQVIGLQHHRLARLFLLEHRIKSGNNMTPEAKHRLEESIRDTVREICGIGRGNQWTPPGMFTACMAISAFGGYFDKIEEQDAMLAILEQTQKDHARPTESVRLEMLKAWGRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEE2</accession>
    <name>A0ABR3VEE2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044976815" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="490" mass="55123" checksum="B78991742A8F7590" modified="2025-10-08" version="1">MKTSAVFSAFLSLLSLASASATSSDRKTYPSTFRPPQVFKNTNLVHIISLEKNYVKENINVLVENIDKAPQNEYYVPFTTDQLSRLGGVEVKDRKDSSIGPFVAEAVELDQSDTHYIRVRLPKALAPGAQQALGITYYLLKAYTPRPASIKQEDQQYLSYTFSAYAPSAYTTSKQKTDVKFPSTTIAEYTKLPGSGDIAEFPQQQGSKLTYGPFDEKPAGATQPVTVRYEFNKPVTHVSRLERDVEVSHWGGNVAFEERYTLYHRGANLSALFNRVKWQQSQFYQPNTWALKEMRFPLRAGSADAYYTDVIGNVSTSRFRSGKREALLEIRPRYPVFGGWKYPFTIGWNSDAKNYLRKTATGGFVLNVPFLEGPRQAEGVEYEQVQVRVILPEGADNVKFHTTIPTQSIASADVVIHRTFLDTLGRTALVIQARNLVDELRDRDLIISYDYPLSASLRKPFVVFVSALAVFFAAWVVGRVELKFDVGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEI8</accession>
    <name>A0ABR3VEI8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="299" mass="33109" checksum="96F75B8EF9CBEE59" modified="2025-10-08" version="1">MAETKNTTKTFPLNTGHSIPAIGLGTWQSSPGDVTSAVSAALKAGYRHIDTAFGYGNEREVGEGIRLSGVPRDQIWVTTKLDNTWHKRVSEALDKSLENLGLEYVDLYLVHWPSSTEPGSDGKKHYEDWDFVDTWREMQKLVGSGKVRAIGVSNFGIRNLERLLGDPSCKIVPAVNQIELHPANPSPKLVAYCSEKGIHCSGYSPLGSTGSLLNKNPTLTALAKEKNRSVQQVLLMWGLQKGWSVLPKSVTPERIEANFDLDGWSLTEEEVAKIDAIKDRFKICGDRWLPVKVFFGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VET8</accession>
    <name>A0ABR3VET8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MATALPHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000117">
        <property type="protein sequence ID" value="KAL1840344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031472">
        <property type="entry name" value="MAT1-1-2/MatA-2/Smr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17043">
        <property type="entry name" value="MAT1-1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="6">
        <location>
            <begin position="330"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="582" mass="65733" checksum="BF856CFBEFD41216" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEV0</accession>
    <name>A0ABR3VEV0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_532</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000116">
        <property type="protein sequence ID" value="KAL1840359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="341" mass="39018" checksum="A519F74EF9DAB185" modified="2025-10-08" version="1">MEVAQTLLRKVMRAFYSTQEILIIEALVTHSALRDDELAYLMKMNLKDLHRLCAGLRDARYLVVHTRPEMQQGKTRPINRTYYYIDYRQVVDAIKWRCYKADKDMQIAVKPTEEAKEYSCPRCRAQWSQLEVLDLCSPEGFICQRCNAILEQNRHEETPGHQQLSRMNSQFKFMTDMLQEIDKVVVPECNFDKAIAVARPVVRDPTHEVAPSVPVDVRTKPDAVKGLANVGPKTMHVTISDDAEQERLEEKRRKEHFLKQNALPSWITESSVPAPSSMAPTSSMSMSFTMPTTNASSSVYEADDVDRSAKRVKMEDGTGAAPMSFKMEDDDEEEIEFEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFD7</accession>
    <name>A0ABR3VFD7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="68"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="516" mass="58209" checksum="4B10BE21BF92D210" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFY7</accession>
    <name>A0ABR3VFY7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="108"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="145"/>
            <end position="177"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="239" mass="25926" checksum="CFD9E109A90E4F4F" modified="2025-10-08" version="1">MEDKSKPDKYAIHEAAREGKLAVVESLLQANPRLAQLKDDDGRLPIHWAVSYNHPEIVSLLISQKGFDPDAEDDSGWTPFMIAASIKEGDKVADILLARGADVNQTNNNGQTALHFLASKNNLDLARRLLESHTPAASTRVRDKRGQYPLHRAAAIGSVPMINLLIKHKSPINATDSAGQTPLHHAVAEGHGDAAIALLKAGAETDKKDVDGYLPLDMAPGSDVKKYILRKAEEEGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3VG04_HUMIN</name>
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        </recommendedName>
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        <name evidence="5" type="ORF">VTJ49DRAFT_475</name>
    </gene>
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        <name type="common">Soft-rot fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000113">
        <property type="protein sequence ID" value="KAL1840437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="292"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="574"/>
            <end position="649"/>
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    </feature>
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            <end position="31"/>
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            <begin position="149"/>
            <end position="169"/>
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            <end position="494"/>
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            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
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            <begin position="576"/>
            <end position="587"/>
        </location>
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            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="649" mass="71148" checksum="4692BD37FEAE4354" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGD1</accession>
    <name>A0ABR3VGD1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_443</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="302"/>
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    </feature>
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        <location>
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            <end position="630"/>
        </location>
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        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="630" mass="67668" checksum="EB79010033E199AD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGK7</accession>
    <name>A0ABR3VGK7_HUMIN</name>
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        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="9 10">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000091">
        <property type="protein sequence ID" value="KAL1840998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="119"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="328" mass="33193" checksum="2106F5BE97E2AE28" modified="2025-10-08" version="1">MSQYYNPPPNQGYAPSGGAQNLQFYPSNYGQPVSGHATPSQASYGYGGPSSGAYGSSAPFTSGYGDPSDVSGRLGEQGGLRTGWLAAFSTEGYPGEPPLLEELGVNVGHIRQKTVAVLNPLSRPDQHLMDDSDLAGPIFFFLLYGTFLLLSGRVHFGYIYGLAVFGSILLHGILSLMAPAGSASSAESVAAGGSYAAAYAAAPGTDAGAGPTAMGSSASAGKNGSSGGLTFARSASVLGYCLLPLLATSLVGIFMPMDKPVGIALSAAAILWCTWSASGIFCAVGGMRGMRALVAYPLALFYVGFGIIAVFSSRGSGSFAKVAGGNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGX5</accession>
    <name>A0ABR3VGX5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="200"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="579" mass="63864" checksum="5A71F13F182B5512" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGY3</accession>
    <name>A0ABR3VGY3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF15">
        <property type="entry name" value="LD37257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="852"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="901" mass="97837" checksum="69739B89E42DB986" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHD3</accession>
    <name>A0ABR3VHD3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="214" mass="22580" checksum="9BC631CE1F2706F6" modified="2025-10-08" version="1">MPSPLPWGVVIVPDPFSFPSPFLFSFPDPKGARQKAEKIVPRRCPCGVASGRGRSRRCGGGSCAGGRATRTCRSGSGRTCCRRGRTAYPVMADTVRILVLSSNQFPSRPPDDPIDESPTPVLVGGHSTRRVACRVIGRGLGGGEFVVGSVSQKGSVAYLAGVDPLAGEGIVVGPHFGGGCRLSLSGLVSAEVRGWFLARFWPNSLVQLWDRAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHK5</accession>
    <name>A0ABR3VHK5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="102"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="534" mass="59497" checksum="4DE016419697901F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI94</accession>
    <name>A0ABR3VI94_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045870973" evidence="2">
        <location>
            <begin position="22"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="779" mass="87572" checksum="07A751892CD0984D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIL4</accession>
    <name>A0ABR3VIL4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_6654</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046073818" description="chitinase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="16">
        <location>
            <begin position="35"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="381"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1841740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="543" mass="58976" checksum="A431A35B172CE85C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIX1</accession>
    <name>A0ABR3VIX1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="4">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="876"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="920" mass="98807" checksum="0B2FCDA74B8F45B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIY8</accession>
    <name>A0ABR3VIY8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongator complex protein 4</fullName>
            <ecNumber evidence="6">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_6516</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="14">
        <location>
            <begin position="394"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="13">
        <location>
            <begin position="548"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1841839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="646" mass="68985" checksum="789E5A2496231950" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJD2</accession>
    <name>A0ABR3VJD2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_6979</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000073">
        <property type="protein sequence ID" value="KAL1841488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="13">
        <location>
            <begin position="37"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1841488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="505" mass="55902" checksum="26D3D686A2B59155" modified="2025-10-08" version="1">MGILHQTLILLAAGIDIGKHGVSALSAAEWRKQSIYQVVTDRFARTDLSTTAHCNPADQVYCGGTWRGLISKLDYIQGMGFTSVWISPVVKQIDGNSKDGSSYHGYWAEDIWSLNSAFGTEQDLKDLSEALHSRGMYLMLDIVTNHMAYMGCRDYAGREATPSGMADHYLLISSMTSSQGLLSDRKLMTGSSLPDLRTGDESVRRIWNQWVAGIVSKYSVDGLRVDSAKHVETSFWPGFSAAAGVFLLGEVYHGDPSYVAPYQQYMDGVLDYPSYYWIRRAFQSPSNTMGELVAGLNTLRGAARDLSLYGSFLENHDIERFGFLTRDVALVKNAIAFTMLKDGIPIVYQGQEHLYSGDKIPNNREAIWLSGYRTDSELYTWIAKLNKIRSRVIAQDSRHLTYDSHVVYSDDHIIAMRKGHAGFQLISVFTNVGSSTSDTATLSSSATGLGANEALVDVMSCTAFTTDTNGGLVVTLANGLPRVLHRDIPTYRHDELDCYNEFGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJX3</accession>
    <name>A0ABR3VJX3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="98" mass="10278" checksum="DAEF1254D85F9EE2" modified="2025-10-08" version="1">MSQRNFLTDEGICEFGILARSQLTRAALSCPSSSDGSSPAVRQGPIREVTRMSKAPLQISPDDGKGTPSLKMTPSSSSAEPDAAAAERRSSGRNLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJZ9</accession>
    <name>A0ABR3VJZ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_1911</name>
        <name evidence="16" type="ORF">VTJ49DRAFT_6132</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000178">
        <property type="protein sequence ID" value="KAL1839047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="14">
        <location>
            <begin position="65"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1839047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1842062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="311" mass="33479" checksum="A593D308A1D273B5" modified="2025-10-08" version="1">MTTFNPSSTQPPPAATASGSEARNKQDDTLPFPPSHRALIAPYLPPAPENDNNTTTTNVDKGKYPFLTLTYASSLDASIALVPGQPIALSSRHTYAMTHFLRSRHDAVLVGAGTAEADDPRLNSRLRREEGDEGPVRQPRPVVLDARARWKVGSNSRVIQTAWEGKGLGPWVFVSESAEVEEVRVRAVEEVGGRYVRLPTGSSGRLEWADVLLALAGLGIRSVMVEGGGEVINSLLVPPGRVFVDAVVVTIAPVWLGKGGVVASPPRVTQMESHGDDNNDNNNPAPLPLRLTDVRWCPMGEDVVMCGRMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK84</accession>
    <name>A0ABR3VK84_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="680" mass="76127" checksum="E34DCF25F40706F8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKV3</accession>
    <name>A0ABR3VKV3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_5119</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046620850" description="Inactive metallocarboxypeptidase ECM14" evidence="13">
        <location>
            <begin position="26"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="193"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1842513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="564" mass="62644" checksum="D1DDB31CA42C4D2C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKV6</accession>
    <name>A0ABR3VKV6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_5011</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000040">
        <property type="protein sequence ID" value="KAL1842535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="12">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="200"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="374" mass="40190" checksum="D9A8A5D62F30FA57" modified="2025-10-08" version="1">MAGATSNANGTAVKASKPNIGVFTNPKHDLWVGETAPSLESVQAVEELREGQVTVAVRSTGICGSDIHFWKHGCIGPMIVHGDHVLGHESAGEVIAVHPSVTTLKVGDRVAIEPQVICNACEPCLTGRYNGCESVDFLSTPPVPGLLRRYVNHPAVWCHKIGDMPWEMGAMLEPLSVALAGLHRAELRLGDPVLVCGAGPIGLITMLCARAAGACPIVITDIDEGRLRFAKELYPQVVTHKVEPGLSAEEEAQTIVSKFGGIEPTLALECTGVESSIAAAIWAVKFGGKVFVIGVGKNEIRIPFMRASVREVDLQFQYRYSNTWPRAIRLIQNGVIDLSRLVTHRFPLEDAIKAFETAADPKTGAIKVQIQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL57</accession>
    <name>A0ABR3VL57_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000053">
        <property type="protein sequence ID" value="KAL1842118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="521" mass="56647" checksum="DFA71E52B4368A96" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLP4</accession>
    <name>A0ABR3VLP4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="3">
        <location>
            <begin position="354"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="456" mass="48612" checksum="571E97D1F800588A" modified="2025-10-08" version="1">MPPKKSKSGRPAGNRVTKPAAKTTTSKIRADDRLLAAAEEAAAAKKAAPSGRGRGRKPAAAAAEEEEEEDTAMTEAPATEVPTSPPPKKKGARGRPKKAVAQAEEAPASPKRGRKGAKKAEAEAPAEEESEIPETQQPDTTQTDAEEERDDLAELPVAQSPARQRPARDTAPTPRSVSKLPLPIPSPDKSGPELRRRLGELTQKYEALEHKYRDLKEIAVKEAERNFDKLRKQSEEKSKAADQLISALKAELAAQKEASKEAARLRKRLDESESQADALQNKVSDLTASLNESKSEIKSLNLKLAAARNGEAAATAAAAKVPGSAMKGSTAAARLAAAHASAASDAALAAHKKKEDLYSDLTGLIVRGVKQGAGEDTFDCIQTGRNGTLHFKLAIDTNPEDGEAHCQYTPQLDPSRDRALIAILPGYLVDEITFPQSQAGKFYARVLKALNEATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLX0</accession>
    <name>A0ABR3VLX0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="453" mass="50603" checksum="5D20DAD34EF8F273" modified="2025-10-08" version="1">MYALGAAFRDRYVRLSRVDEHVGIVGIRPRTLDNSQLFIQTSTDGCSATSAIAFLQGLYPPFPRVSCDRTVPEHTRLPDNSIVNYPMFGYQYPNIRTSDPDHDPDSIWTRGFSRCKKHEASLLMFPNDTLADVLHQRSKTIYGRLWDKVFHDAFPRSEATFFNAHELYEYAVYRWIHDPKIHSALTLGDLEQLQGFAWQEQTLKYAPTTGSSNSPVDLASTMAGRTLVSRVAALFTENIASRGERNKLNLAFTSHEPFLSFFALSDVCLSDHIEIEATDVWSSNKSGSEVDGDDYGHDGSSNHDGADSDSDSPTERHNKTDHTEHTPYIAQSPSPDFSSSKLRRRRSISTSTYPSIDNLYVRFLYRNGSADPKLPPAPCPLLGNTRTAMSFRHFNETVWSVGVANATSWCGACESDAFFCKGAEERREPHHKLAAFIGASAATGVLVVLNMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM08</accession>
    <name>A0ABR3VM08_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03524">
        <property type="entry name" value="RPA2_OBF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF33">
        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="449" mass="49424" checksum="53D25DCFA5910A82" modified="2025-10-08" version="1">MTDATKPEENTFYPQYCFHLSPTINRWCHLRIADIWALRTHPGFQGQDVYFHLNHPIKWVRIAGVVVAVDERETRHFYTIDDGSGATLECVVNLPPKAPPAALAPGKPASEPSNAAPSSNNDARFPVVDGPIDVGHVLDIKGSVGTFRDSRQIRAEKIAHLRSTDQEVAFWEKVVRLRREVLDVPWALDPRVVRRCRREEEGRARGPDDAGHSRRRHRTNTGDKDVARTGLERRTKVTGSGTATAGLHSETGRTGLERRTKLTSSATVATLDSESRLGKAAGVDSESRKTGLERRRPAEPTSRRADSEKTTSLRTGLERKTRATATATTTGLGRSGVEKDRPGEPQGWAEFEKTASLTTGLERRTRATTTTPGLGRTGLENGRREEAQGRASRNEQTASPSGEIGTKTGLEKKPLAERPALVTGLERRRTTKQFTRLVPVTGKYDALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMB4</accession>
    <name>A0ABR3VMB4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="9">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Gcp-like" evidence="9">
        <location>
            <begin position="230"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="505" mass="54671" checksum="E73B11E2D2A58455" modified="2025-10-08" version="1">MAMARTALTACGRLRGLASRQLRVRYGQTLCLGPSGFSRQATTATASSGTTDSSSSRRAHRSLLTLAIETSCDDTCVAILEKHGPAARLLHDDKATSDSRKFRGIEPTVAVTGHTSKLAGLVDKALRMLPKVESNGSAGEGVLFLGSDGLRRKPDFISVTGGPGMTSALAVGLNTAKGLAVAWQVPLVIVHHMKAHALTPRLVHATGLPWPGESNQQQQQEKRKKEAAAHPAFPFLTLLVSGGHTQLVLSRSVTSHTMLAEAKNVAIGDMLDKCARAILPDDMLDQANSVMYAAELEPFAFPELQQQQQQQQGQANKNPYNYTPPRTRQDEIRPYSSPTHGWYLTPSLANRRDMAFDFSGLGGQVQAIARRSDSPPDTPPPDLTERRELAHHAMRLAFEHLASRVLLALDAMRAEKKRVPKTLVVSGGVAANGFLMHVLESMLKVRGYGNVEIVRPPAELCTDNAAMIAWAGMEMFESGELGEAGGEALEWLPRAKWPMEEEKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMF7</accession>
    <name>A0ABR3VMF7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="183" mass="19771" checksum="6E3CBF0920AECA69" modified="2025-10-08" version="1">MAPAAPSSSQQQQQQSSQPAPTQTATVTTTQTPAPPQAILRLRGAYDPNRPSVRWRSDVVDNEGMNKKKSKVCCIYRRPRNVDSSSDESSSSSESDSDSDSDADSDGGRRPGDADGDKHAHHHHAHGHGHDGCNHSYSRSGRSKGKSRRAKRNPSPNAYEKMPRYDKPKKDKGGGGDGGPQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMI2</accession>
    <name>A0ABR3VMI2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3045</name>
        <name evidence="8" type="ORF">VTJ49DRAFT_683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045031820" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="20"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="432"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="151"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="558" mass="61965" checksum="47A8159B808AE9E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMQ3</accession>
    <name>A0ABR3VMQ3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="197" mass="21324" checksum="8BE4B2C739FBA3D2" modified="2025-10-08" version="1">MAITTSTTIHAIPPSTANLTNTASEPSKNPTPPSPNLQTPPNHHQPTTPLPDTWEERRRLWKKKKHALQRQTYRKSAKATLGLLGPSSEDLRVAGVEVRDFAAGAEAEDEDAAKDEEKDRNKDKAKDKDKVRLGMKRRWGKMAGGGGKIRRYLGRTRDGESPGGGKVGNVEGEEGGGSRRAGKRVKVDDDGVGGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNA1</accession>
    <name>A0ABR3VNA1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="139"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="492" mass="50215" checksum="5D3DFEF4760F789E" modified="2025-10-08" version="1">MISHESQHLPLHRERRRLHRRQQPATRLPCPRGNGTTIGGFQDFTVLCNTSIEGDVLERMDAFDLRTCADICSSFHPKCEGVTYDGSQCTLRARLRPEERRPSFRLDSALAAFPEASSNCPTLGGTQSVAQGTITFTTMCGTIIAGNDLGQNFAPTFQDCLGQCGATPGCGAVSFDPSLELGLKNCYLKSAPANPGDIAAHPLTDSALLVTGGGGAPGAGAPAVSGPGVMTIPVPTGTAGAGVIFTPPGGAASPTVSTVTVTEPGSSESSSSTEIPASSSVDTSLLLPSTSDVIPATTAVSSSDATAAPADAVDAAANTPSMAWVAAPVVGGVAAVALIAVSFLMLRRRRRSSGRNRGRRPGSSGSGSGSGGWLTGWLPAAWTSAGKGSHTEKSGKGSGSGRAVSRRMTGIGNFSAVESAGRKSFDAGGRGSVRNSVVGFVTGRPAGMERLEDVPEGEGEKGKEARKSTRTGGELRDSLNGLVQNKWKGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNA6</accession>
    <name>A0ABR3VNA6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="182"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="350" mass="40189" checksum="0862C3DE9F7EE354" modified="2025-10-08" version="1">MATGNTNAGGGIKITDWVKPSDTSGEFKRQQSSFRNWISRKPGAQFPPEKGRYHLYVSYACPWANRTLIARKLKGLEDIISYSVVHWHLGEKGWRFVTAEDGDPEGENVIPDPVPGHESFTHLRNVYFQANPSYEGRFTVPVLYDKKLQTIVNNESSEILRMLGTEFNDFLDEEHAKIDIYPEHLRAQIDETHEWQYDKINNGVYKSGFATTQEAYERNVLALFEALDRAEAHLKKAAADGPYWFGKTLTEVDIRLFVTIIRFDPVYVQHFKCNLRDIRSGYPAIHNWLRRLYWTVPAFRETTNFAHIKKHYTKSHTQINPLSITPLGPVPDILPLDEEVPAAAVAKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNC8</accession>
    <name>A0ABR3VNC8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">VTJ49DRAFT_1769</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="21">
        <location>
            <begin position="311"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAL1843419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="694" mass="77111" checksum="FACC6AC2BBBCEBB1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP03</accession>
    <name>A0ABR3VP03_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="374" mass="36778" checksum="85492AB3384A5A66" modified="2025-10-08" version="1">MAGPPSPGGEGPTFAPPPLPPGWIAQWDASSRKYYFVQLSTGASQWEVPTEAAPVGSTPAPHGDSPFGLPGRGGSPRDGAEIITYPDGSQTARYPDGRLEPLHPREDGTPGDGTRAIGGPGGSSDRGLGSLLGGALNSLGGKPPGGSQGSGGLVGGLVGGLLSSSSGHSGKTSSGGLGGKLAAQVASNIFSSGNKPASQGSSFPGGHGSGHGSGGLGSLLGGHGSGGSGGLGGVIGGVASHVLGGKHSTRQNDFGYTNNPQPGGYSGTAPPASYQPPSQPGQPTTVPSYSGSAASYAASSSPAQGTQSTYHQQNYAPPPQHSPHQGYPPTPGSYGQPQYGNPPYGSAQPSSYPPQGPYPGSAPPPHHQPYSPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP04</accession>
    <name>A0ABR3VP04_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18230" checksum="C9BB6A9D75E7DCF6" modified="2025-10-08" version="1">MYALTLSAELAGVTNLRPRDDQEQNFFYTFKVQCTSCREIHPNPVAVSRFETNEISGSRGEANFVWKCKNCKRESSASIKAAPTPYEQTEPAKPQKILEFDCRGLEFTEFIPEGEWLVDGIESGTKFDGVELTEGEWFDYDEKAGEEVSIKDIKWDIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP46</accession>
    <name>A0ABR3VP46_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="137" mass="15349" checksum="407152AC157B3126" modified="2025-10-08" version="1">MTVRALQKISVARNGVGAFILQCKKMDFHYCDWAGSSKGMNGFIKSLLPKFAAAHPQIEFTVSPRPAKHPVIIAHYINGREKAVCVRNMEPFEILKKAELLRDASGEKLRRVTKPVSSINESVRGIWSPYHGEGMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP54</accession>
    <name>A0ABR3VP54_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1843669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11588" checksum="F98B71F5076A22B0" modified="2025-10-08" version="1">MQPSRVLRAMGHDPKPNITGFDMRKFLAATGTPRYDPWERNEAWRYTGRFSRFNRFRNALPGFGIATVAFAGYCLYEHFFLQDHHHHGHEKHHDEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP57</accession>
    <name>A0ABR3VP57_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="118" mass="12703" checksum="9C2D3BC07D0BDBDF" modified="2025-10-08" version="1">MVCAKCQKLNKTTLATPGVKKKTEMYYGSPASSSASSEKKSATLGQTGISKSKLLSKAAKNPYAQYSSSCIRCKTKVARGHSYCNQCAYRADVCHICGKSNKPKSTVPTVEGQKRTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPV3</accession>
    <name>A0ABR3VPV3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_872</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="431" mass="47768" checksum="5363378D64239D44" modified="2025-10-08" version="1">MEGSESTEVNAPAATNGKRKADTELERDAKRTTPSKEEEPTTHDQSTINENGTLQNDAATGTDDKPLSKNQLKRLRRQQQWEAYKETRKTKRKEKRHERQARKRAEREAKIAEAEAAGIDPATVLQTKEPWKHRPVPVTFIIDCDFEQYMRDHEIVSLSSQLVRSYAMNRKAKYQAGLHFSSWKGKLKERFETVLRNAHKNWKNVSFHEGDFREAAKLAQEQMTGPNGGELIDVIRPSEDGLKQPSGSEAASTDPMEVEAEGEDVDKSIVYLTSESPYTLERLEANTSYVIGGIVDKNREKGLCYKRAKDFKVRTAKLPIGEYMAMQSRYVLTTNQVVEIMAKWLECGDWGKAFLDVIPKRKGGTLKNGGGGGSEEPGEGGSDGESEESSEGEEAEDRAKDAAPAAAPSADSNSAPQLQESASTQAVSGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPX7</accession>
    <name>A0ABR3VPX7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="180" mass="20832" checksum="AFC0CB5779B8F567" modified="2025-10-08" version="1">MSSSTATVLNLSELTRQRRRMARRLGFDSTDALDDWEEMVVADHFAIFVIDYLARGYCITPDKRELIRHVDLKHAVKRRVRMLDESRFDEVIGEGGDKSDWTAKDHYKAFIVGVVADDKWLGSHNVDGTIMKHRPWSPLETTLKMLRYLEDLIDEWLQSAGDCAGRRKAGLPERRVVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR08</accession>
    <name>A0ABR3VR08_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="331" mass="35662" checksum="D4385F8C946A2BF5" modified="2025-10-08" version="1">MTTYYYMGDSCSGTTALGYYHANVEGDRSVSVTVDLPCGRTCTTVMIYEASPTVGPSLSWIGCPEMLGLPQGVYTIYSQRPDITDITSTSSSRTRTTRTTDNFPSETQTSSTGSPTFDSSNTADDSSSSSGPNAGVIVGAVVGSIAGVAIILLAFFLGWRYASRKNKPTTTSNPPTNPPPNPPTQPYYTPELEGAKVQAGVPVSTSPAPTYDPAQQHQSMVYNPALQQQQQPMVWNQNQGAWGHQSVYYPQTGQMPTPQQLPTDTGPYEIGSSYPYTYQEQTGTYVTPTQPAQPAQLEQPDQHLGQPLGPQLAQRLEQQAEQQQSGQQPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR67</accession>
    <name>A0ABR3VR67_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23352" checksum="3567CBAF2F78DF21" modified="2025-10-08" version="1">MVRAGLPDKMAQTQQACPLAVSNLRYPQPQALVMKEWGDAFKVTLGNNQIMTVQRRGVFGFSDLGKQVKELYMGNTKLLTITHDRVWFGRPTISINRVTGRQGEDGTPVMKTKPGRAVWLGRRKMTANLMPPGSEPVKVTLKTKTFNSAKGSIVNAASKQTLATIERKRFSAREMLAGQQSYTVTVQPNVDMAVVSAMMVCFDEFFYEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR91</accession>
    <name>A0ABR3VR91_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="385" mass="42090" checksum="98138945FA768CBC" modified="2025-10-08" version="1">MTYFPGTQYRAHTSCISEAQKYQGALYREKKPKGQPAPAQNQNNQADPAQNQNHQPAPDVMAHVAYVEDAKDEDNYDWRRYREQSDDDDDQSFKSFNRMPEAPSPPPAVPDEGPLNVFDFLVNNPTPTASHVSLPATAQAPPQPSDNNQLVRFDPEANGMTEIPEDDKALMQWGSGSVPNGFETPAPKETRRKVKDSEKESSSKKDKKRKRLHIEVDHPMTDAPPVLHTGLTGGLNRMMSKSAMFPLPPSPDSYDAGDAETPASPLKKSKSKHRSSRGPDTLGNSLMAMLAGASKPKSSSSSKKRTKTKSSSTPSKTKKKKRSSTSGTKALDAPKEPKLLEFRPVSKDGKGGGDESSALIIYKPPAEHFLSFVNKGPDSIKGCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRC1</accession>
    <name>A0ABR3VRC1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrroline-5-carboxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="215"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="32789" checksum="D9C806B3C1A1EEA0" modified="2025-10-08" version="1">MSAIQSNSSSSELTMAVLGCGTMGIAILSGILTALDELPGGANSKPSASGTSTPLYETTTTTRLPSRFIACVKRPESVKKLKAAFASHLSAVTIAQNANVRSAQESDLVLLACKPYMYKDILSEPGMAAALEGKLLISILAGVTEAQISAILCEANGGVPVPGCRVVRAMPNTASLIRESMTVIGISDPPLEPEALGLVTWIFKRIGDVVYLPPSTMDVCTALCGSGPAFFALMLEAAIDGAVAMGLPRAEAQRMAAQTMKGAAGLVLNGDHPALLRDKVSTPVNQTSLPLRENDTLDIATANAVEYTSLQQVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRF3</accession>
    <name>A0ABR3VRF3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2298</name>
        <name evidence="2" type="ORF">VTJ49DRAFT_6786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="661" mass="71904" checksum="C5A5F0D9A6C64599" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRV7</accession>
    <name>A0ABR3VRV7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_72</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="172"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1844393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="643" mass="67606" checksum="295874CB06B6A520" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0S3</accession>
    <name>A0ABR3V0S3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000695">
        <property type="protein sequence ID" value="KAL1835384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26948" checksum="51DC13C6EDEA4D1C" modified="2025-10-08" version="1">MYQQALKGREKALGQDHPSTLDTVNNLGNLYDDQGRLTEAESMYQRALEGYEKALGRDHPSTLTTVHNLGNLYADQGRLTEAKSMYQQALKGREKALGQDHPSTLDTVNNLGNLYDDQGRLTEAESMHQRALKGKEKALGQDHPSTLETVHNLGVLYANQGRLTEAELMHQRALSGFWVALGPSHWKTQLATENLDCLLQTTKDSSAITKPPPLKAKMTKLEKLREKFRGFLKERRRPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V114</accession>
    <name>A0ABR3V114_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000686">
        <property type="protein sequence ID" value="KAL1835404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="701"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="984" mass="107947" checksum="59084C6DB2CCEC35" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V158</accession>
    <name>A0ABR3V158_HUMIN</name>
    <protein>
        <submittedName>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 620.91</strain>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAL1836100.1"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="806"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1106" mass="122710" checksum="918AF9F6078B1F82" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2X7</accession>
    <name>A0ABR3V2X7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000469">
        <property type="protein sequence ID" value="KAL1836076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="26"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="485" mass="52783" checksum="580AFFAAD4570C2D" modified="2025-10-08" version="1">MTVDNQDSGSPAMRFEILKALKDGAAARVGRLAFAGRLPIDTPNFIAITSRGAVPHITPDNAEKHLKTTGAYMALEDFIERPQQYLKRTPPIYQASTTPKHPTRLHSFTATPPSVTTILSARRLPAVPAPMGNTTNAVSVFTSTGFQSLTTTEYHSAVEALRPDIAIPLADLTHTTTTPNSKRALRMAERTDEWTVEWFSALSNSNVSTFAPVLPIPYSIQWEYISRLAEDYLPTGQLAGLALYDADVLPDLESHSPSLLPLPRLAFTNPPTPHHILRQISLGIDLFTLPFLNQISDAGLALSFTFPAPPDSKDMPGPQPLAIDLSHPTHATSLLPLSPTTTNCACYACTSHHRAYIHHLLHAREMLGWTLLQIHNHAVISSFFAGVRATIAEGGADALEQATKRFATVYEADFPEGMAERPRARGYQFKSVGGGEGKRNKPAWGKLGGNEDGNGEGKTEERGGEEEDGIVKAVEEMAVEEKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V381</accession>
    <name>A0ABR3V381_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000441">
        <property type="protein sequence ID" value="KAL1836249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="176"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="406"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="607" mass="67296" checksum="7173BB83920B4EFD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3P7</accession>
    <name>A0ABR3V3P7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiophore development protein hymA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000416">
        <property type="protein sequence ID" value="KAL1836404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42734" checksum="C3624716BB14894E" modified="2025-10-08" version="1">MSFLFGRARSRTNTSDLVKQARDHVTKLEGPQGPAKAEELAKVLSQMKQILQGTHDSEPNTDQIFQLVTSMIDEDLLYLLAVHLHQLPFESRKDTQVIFSYVFRFRPPAGPQKPEPLALAYVVERRPQVLIALCRGYDHKESATPAGTVLREVLKNEAAAAIILYDDGDEPGSSSRGIAGIDPDRPQSGRGVFWNFFDWIDKSSFEVSADAFTTFRELITKHKDLVPRYLAVNFELFFERYNRVLVQSNSYVTKRQSIKLLGEILLDRSNYNIMTAYVDRGEHLKICMNLLRDDRKMVQYEGFHVFKVFVANPHKSVPVQKILIMNREKLLQFLSHFLEDRTEDEQFIDEREFLIKQIRNLPPAPVPPQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3R1</accession>
    <name>A0ABR3V3R1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000441">
        <property type="protein sequence ID" value="KAL1836245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="231" mass="25471" checksum="9DD5BA00CD7DEAB1" modified="2025-10-08" version="1">MSYDHVRDKTSSAVGKDDGEGDSVLFDETIAAYSQRRKRAEEFLSEALVDSHRKAFRAYLHRTQWSTVADDAAAGADGAITPELDEPLRILKRDLTFLQRALGTAPFRRVWRAALEQLNAALWSDVLMANRFTASGAAQLSRDVCAVAGLVERFIPDGSAALVSMDEALRLLNLPVEEEEGAGNGLSLRRATDRVFTDNAEAKKVLEELDVVTLTPANARQILQRRVENAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3U0</accession>
    <name>A0ABR3V3U0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000413">
        <property type="protein sequence ID" value="KAL1836422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047011752" evidence="1">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="176" mass="18996" checksum="23B500F3D3F13816" modified="2025-10-08" version="1">MLPNFPSALSLLALLLTPLSQTANAAPAPAPAPAPQDSPKPCNPDPCGTLPVFIGWVPYCHQGALYCTVGPGMVTVSVGRCEEWCQPEPPKPQCPPPRPPPAENCRSDPCTGVPLNGWERVEGWEPYCYQERMFRLICEDVVNAETGEMYARTARRRVIQVSTTSVITSACDGANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4J0</accession>
    <name>A0ABR3V4J0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000380">
        <property type="protein sequence ID" value="KAL1836674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="2">
        <location>
            <begin position="54"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="162" mass="17521" checksum="68C0B74FA4919EC7" modified="2025-10-08" version="1">MSLKNGKHRCRHPRMSGHCKTKNDVAQPESRWSTADLIGNTDKFPSSAAFDAINAALNASEADRKDAIKQGNAVFAFTLKNAAGETDSWHIDLKEKGAVLKGLPEKANVTLTLSDADFASLITGKANAQRLFMSGKLKIKGDVMKATKLDPILKKAQTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4N9</accession>
    <name>A0ABR3V4N9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase II transcription factor B subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000380">
        <property type="protein sequence ID" value="KAL1836676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="212" mass="23629" checksum="24E70D356489E73E" modified="2025-10-08" version="1">MPRHAALAMGRLFRRGAMLVPHGAGFTSRDRTPATRKDLAVHNDTSDAAYDFENLAFTTPMLPGPSPAVTGTISKATKTEAKATAEIKRLEARVAELEAREKWLFGLLSHESKVAMWNRMNASSRTSPRSASSPNTTANMVKAIRGVLIECEPAIKSILVHIDNTHNHMFIIEDLDETHLFVKEPMLPALKQKLEERLKETYRPEEPLDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V581</accession>
    <name>A0ABR3V581_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol uptake protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000372">
        <property type="protein sequence ID" value="KAL1836732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="72865" checksum="D21A5337139E05AF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5C1</accession>
    <name>A0ABR3V5C1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000345">
        <property type="protein sequence ID" value="KAL1836962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="450"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="92978" checksum="ECB1A139FFB30901" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5L8</accession>
    <name>A0ABR3V5L8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000349">
        <property type="protein sequence ID" value="KAL1836920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="165"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="521" mass="57588" checksum="592C3F2794F14930" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V655</accession>
    <name>A0ABR3V655_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000329">
        <property type="protein sequence ID" value="KAL1837100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045049293" evidence="2">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="215" mass="21482" checksum="ADD13B5651802485" modified="2025-10-08" version="1">MKHTSSMLLTAVTAAGLAAAQASTTTVSVLLPFADHQDIEGSVISAGPTATNYFLTCPTGARDTECGFGDGISVLYGPSTLTYAMSFTGLDEKSSTMSYSIGASCSLDLSKDIATCTATMVSGTDTTTYREVAESFTEYIMPVTITAGAEKLQAAATGGSGGEDSPATTPAPTPTGGSDAARASDGTSSNAAMPRITQNAVVMGAAALVGGAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V672</accession>
    <name>A0ABR3V672_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000328">
        <property type="protein sequence ID" value="KAL1837115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="240" mass="26540" checksum="81DF1B65E83EF4B9" modified="2025-10-08" version="1">MVLTHTTNHTYSHPFPTVTLAFFLRYCSPQLNPFASHVLSTDTISSHVDPATGRLHTTRIHLKKSRLPPAVMKLLPTTLTGGTSDKASYILETSVVDMREGWMATESRNLNYVGVLSVVERQLYTLPKNRPAAAADSTDVETKVVFRSRLGERIRDRLGEARDRAEAAAESSGGGFFARLGARGVQRSIETLASTKTQDQLGKSREGMRIILERLRHTGIMGVLELRKMASQRGMQAPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6B6</accession>
    <name>A0ABR3V6B6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000314">
        <property type="protein sequence ID" value="KAL1837246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="404"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="574" mass="61938" checksum="529245B0A2EAF63D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6H8</accession>
    <name>A0ABR3V6H8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000336">
        <property type="protein sequence ID" value="KAL1837031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="621" mass="68538" checksum="3F9FE3ECEC240F05" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6U2</accession>
    <name>A0ABR3V6U2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3737</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000289">
        <property type="protein sequence ID" value="KAL1837493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039470">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15891">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="13">
        <location>
            <begin position="149"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="836"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1837493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="933" mass="103578" checksum="16CEE1947C9EE78B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V753</accession>
    <name>A0ABR3V753_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_3635</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000281">
        <property type="protein sequence ID" value="KAL1837575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="338"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="578"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1837575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="790" mass="89461" checksum="C1840CD7CE7779DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7G6</accession>
    <name>A0ABR3V7G6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery associated TMA7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000271">
        <property type="protein sequence ID" value="KAL1837696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7197" checksum="553DD62D70FAB2D0" modified="2025-10-08" version="1">MGGQSRAGGKAKPLKAPKKTAKELDEDDKAFLEKKRAYEKAKAELAAKASGRGPLNTGQQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V807</accession>
    <name>A0ABR3V807_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000256">
        <property type="protein sequence ID" value="KAL1837876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="374" mass="42241" checksum="FA72E2B6E6BF1C7A" modified="2025-10-08" version="1">MSLPSKWLHIYDDFITKNAHQVAQIESTLRSLTYIIPGRFRDAEIASESIHSGVQLLSLYHDALLRRAHAVAKLAASQPSEPPSPHARYTRHWTNRSPLYRRVAYLLQVVQYVELLCEMAAKRRGGEQARWRVVVLLESIKAICRLVLLRVTRSRPIVTPALPERGPLPEEPPGNNNEYDEETLGMGEDDEDRGLLGSIGGSQNSTASANNEWTMSRTGMSLPALPAPGDTSGFLLSRVLTADDIKPAAKLVNTLRGQARAAEVLHILAPLVFAIALARCKDKRRAWTPWLLGVGTELAARQLRDRGLRTTPLEREEWSRRAWSMGWWVMRGAFYENVTKGVVERVRRRMPGLLAGIVEDYEYLWENYYYSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V821</accession>
    <name>A0ABR3V821_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000316">
        <property type="protein sequence ID" value="KAL1837228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="168" mass="18370" checksum="594A4E32D99A9318" modified="2025-10-08" version="1">MLTRTKQRRSPTATFSSTASTSPARSPTLSTWSPSRSPTASSPSCATSRPTSPPPSPPSPSTPWPPPSTSPPCASRVCPRVHPRSPSSPSTICRLCSRARRRKRLVGTCCPRSSRSTTGATRLSGPGRTSCSRRRWRVCRLVRWSSKRAPRTDVVGRAMYDSFGKMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V825</accession>
    <name>A0ABR3V825_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000263">
        <property type="protein sequence ID" value="KAL1837790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045439048" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="154" mass="17543" checksum="391E877B2D7CBD93" modified="2025-10-08" version="1">MLSTTFTKTIAAFLAAMSVVQAAPTTSDVEPLPADIEAHKNASVYGMLANEYEAWRTSKPNHNGYWEFGPGDAWKCYDLSPKLFHQLNTFYTIQGHFTCVLRNSKCTQFCPHNCRLRTHISYDYSYNLSSIGWDTKAESYYCFQESEPWPSPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V877</accession>
    <name>A0ABR3V877_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000248">
        <property type="protein sequence ID" value="KAL1837964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="202" mass="21210" checksum="3AF1F27DDA83A607" modified="2025-10-08" version="1">MRPRGVLAAGAAVVAIFVDGVLAGFTNSFEGLTSGSTITLAWQEADAQARNVPLCITAQVIDRSSDGFSANAYSVNLTTDASGTSFTWTNAPSPLRWIQDGLYQLELRPANWDGPDVPLLARSPHFTISAPAPAATSASSSSTKSDNDSGSGISTPVAIGVGIAVGVPSVIATAVVTWCMRKRKRQADLEKRRLKRSDFVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8D2</accession>
    <name>A0ABR3V8D2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000305">
        <property type="protein sequence ID" value="KAL1837333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="99" mass="10607" checksum="D6552591174F6C12" modified="2025-10-08" version="1">MAFTGGAKEGYSGRVCMNTAIGMLGFLFASLSEGLYVTSSSQYPTGCCPCHRLSAMERKHWMHELQNTLPTSGSAVTANPSALIYLSLKARSWPVGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V946</accession>
    <name>A0ABR3V946_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lon protease homolog 2, peroxisomal</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000226">
        <property type="protein sequence ID" value="KAL1838264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03121">
        <property type="entry name" value="lonp2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027501">
        <property type="entry name" value="Lonp2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="758"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="8">
        <location>
            <begin position="961"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="851"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="894"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="515"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="963" mass="104397" checksum="C59907EB2DF838D1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9A8</accession>
    <name>A0ABR3V9A8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000215">
        <property type="protein sequence ID" value="KAL1838419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="301" mass="34248" checksum="BD5C75F8DBBEADF0" modified="2025-10-08" version="1">MSSSDEDDGPQLPLPPYVPGFSIYIKNHQAPEPFGPDYGWTPRPAVQIDRDRQWEMDREEFALNHPPIETKPPEGGSIGTSFTITDTKTLHRRGGPQVVVGYLGQDQTTKYILKIFDSVYYRLVEKGTEYDCTLWADKDYATEFWAYSAMMETEALRGMVPDFYGGFTTSLNTRFPGRQRSVRSILLEYIPGENMMTKISRSLDSNGVLQAKLLPPESQRLEVLRQIMTIRETLYFDGAISHRDIYPRNIVIQENNDGNVRVAFVDFNRALIYRPIESVWPFLPFGCSLAKPAGGGDIWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9G6</accession>
    <name>A0ABR3V9G6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="224" mass="24935" checksum="82FC6AF1C3C5E058" modified="2025-10-08" version="1">MSHHCHDEHVHSHGHGDEHDHSDDITPALQHSLYQHIHFDEVTALNEARHGLAREVVKKTWAERLQVEPELESDVDEQLIVNVPFTGQVKLHSILLRTSDSPSAPRTLRVIINRDDVDFGVAEETSPTQEFELSRTAEVQELPVRRARFNAVRRLALFFPDNFGDGDEDVTRISYIGFKGEWMALGRAPANIIYEAAANPSDHAIKGTSVNQMGSGIGGRGPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA66</accession>
    <name>A0ABR3VA66_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000225">
        <property type="protein sequence ID" value="KAL1838276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="183"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="213"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="270"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="279"/>
            <end position="302"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="425"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="481"/>
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        <location>
            <begin position="487"/>
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    </feature>
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        <location>
            <begin position="766"/>
            <end position="799"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
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            <begin position="632"/>
            <end position="653"/>
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            <begin position="660"/>
            <end position="670"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838276.1"/>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="900" mass="96888" checksum="04B13A81263F33C6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAP2</accession>
    <name>A0ABR3VAP2_HUMIN</name>
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        <recommendedName>
            <fullName evidence="9">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    </comment>
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    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000187">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    </gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="80919" checksum="5FD35B61D03821F0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB11</accession>
    <name>A0ABR3VB11_HUMIN</name>
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        <recommendedName>
            <fullName evidence="8">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000183">
        <property type="protein sequence ID" value="KAL1838962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="447" mass="49981" checksum="62036085E96F91DE" modified="2025-10-08" version="1">MREIVHLQTGQCGNQIGAAFWQTISGEHGLDSNGVYNGTSELQLERMNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNYLVSAVMSGVTVSLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVSVPELTQQMFDPKNMMAASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTAIQELFKRIGEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDAGIDEEEEEYEEEAPLEHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB65</accession>
    <name>A0ABR3VB65_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000217">
        <property type="protein sequence ID" value="KAL1838398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF904">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="54"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="644" mass="70761" checksum="6FD324A81231D996" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB97</accession>
    <name>A0ABR3VB97_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000181">
        <property type="protein sequence ID" value="KAL1838986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="378" mass="40971" checksum="BF25DDED4B771A0F" modified="2025-10-08" version="1">MTQTDPPPPTKPIPITIVTGFLGAGKTTLILNLIPQLRAVNPTYKLALLKNEFGDLAVDSQLASSSAISGVTELLNGCICCNLVGQLGPALRELRETVSPDRVIIETSGSAFPATLALEVNRLAREQPGSYVLDGVVSVIDVENWTGYDDTSYTARLQARYTDLVVFNKWEGCDERRLDEVRDRLGDLEVDVAWVKSDKGWVDAGVVFGVDGGLARGLTDEVVAAEEKCKGGEGCGHEHGKEKHHQSEVEVLSVELKGDGAVDADKLMGFLQKAPKDEVYRIKAVLTTSGTVKNSDAATATAPSPRGRYILNWAFGRWTFTPIADEVTEHESSSEALLKMTVILARYESNKWKKKLEAGGLLELDGSDKGELTVTRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBI8</accession>
    <name>A0ABR3VBI8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000169">
        <property type="protein sequence ID" value="KAL1839220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046972457" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="500" mass="54816" checksum="30C564B1BC3A3C58" modified="2025-10-08" version="1">MRLIIALSTAATLAAAAAVNQKRAALDDCLLDAGVPTSTPGTTDWTIDAHAFNQRLKYTPAAIAAPTTIEHVRLAVECAVQVGGVKVTAKSGGHSYASFGLGGEDGHLVVQLDRMDEVELDTETGIATVQAGARLGHVATVLIEEGRDFSHGTCPGVGVSGHTLHGGFGFSSHTHGLALDWAVGATVVLANGTIVEASTTENPSLFWALRGAGSNFGIVVTWRFRTFVVPETVTAFEVNLPQWRTNATTLAKGLAELQDWLASGGMPKEMNMRLLGNGFQVQLQGLYHGDSEGMRAALAPLLPRLGTGVNATGVREYDWMGGFRHYAYSAQIDVRRPHRQAETFYAKSLVTGALPEDVLQRVAEYWVTKPATAARGRSWYVLIDMYGGPNSAITQVPKDETSYAYRDPQKHLFLYQFNDGSFFGQYPANGFEFLDGWVKTFTDGLWEDWGMYINYADPRLERERAQEVYYRESLPRLRQLKKQLDPDELFYYPQAIKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBR0</accession>
    <name>A0ABR3VBR0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ste24 endopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000204">
        <property type="protein sequence ID" value="KAL1838608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="12">
        <location>
            <begin position="136"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="11">
        <location>
            <begin position="323"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="555" mass="63274" checksum="CB02F69E55E6768A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBU3</accession>
    <name>A0ABR3VBU3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000170">
        <property type="protein sequence ID" value="KAL1839196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
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                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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</entry>
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            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Tsang A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
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    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="128"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="662" mass="73967" checksum="4A8C73D6065388FD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCI5</accession>
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    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_1489</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000156">
        <property type="protein sequence ID" value="KAL1839451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1839451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="505" mass="53819" checksum="A6D803BAA3B629D0" modified="2025-10-08" version="1">MVKPNPQPPAPPKPKTHTNNAFFTNALTHPYRTLTIAFVAWKLILFLIAFGAVLAGEAYDSSADLVVHGTGSGTAPRNSLITRLVTRFSSWDAIYFVSIAHGGYLHEQYWAFGSGLPGVVRGVVTVARSLGLASPAGSDGGGAFVEAVTGIIVANTAHLLSTFTLYRLGEVVFESQQREQKQQTTLLPLLAALLHILSPAGLFLSAPYAESSFALLSFTGCLLFALACRLDGYGNHPVLRDAYTVLAGVVFGAATVFRSNGILNGIPFAWEAVRQLAGLVCEHPRRSKVDVLRRLVALGLGGVCVAAGTVIPQAVAYQRFCLGAGEGSVDPRPWCGGWVPSIYAFVQSYYWNTGFLRYWTISNLPLFLLAAPMLTVLGVSGMAQLRGELVPLSSTTAAPKSAPSEEKSAKISSQRSPTSSSSIQSLLTAAAAAQVLLAVLAFTSYHVQIITRLSSGYPLWYWWLAGKLVQKSTHKDAILANRVVTFAVAYAAVQGGLFASFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCJ3</accession>
    <name>A0ABR3VCJ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VTJ49DRAFT_1618</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="JAZGSY010000162">
        <property type="protein sequence ID" value="KAL1839350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20072">
        <property type="entry name" value="SET_SET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="1149"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1275"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="376"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="530"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="740"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="841"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="549"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="895"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="949"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL1839350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1291" mass="145290" checksum="03F195C032C71869" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCM4</accession>
    <name>A0ABR3VCM4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000156">
        <property type="protein sequence ID" value="KAL1839452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="334" mass="36325" checksum="DA24EAA6FD6CC0E1" modified="2025-10-08" version="1">MTWLIKALNSPNRHVENRLPPTPIARNILFEKNGRLVRAPTPHPLMEPSFNGRLRAPTSKLSKGQIIYLIVLRALTAMVISGGLGLLAGYFIYSSPRPPYGPPPMGSIPPFIFRQPKSLVLDALLTTFVQCILTFMTQQPLVNHHMAQGRVRGLHVCPEPKNRLLRWWFMLDCHTQDKGSALFGGCFNWVPGHRLFGLFFGSVGRGLITVVPAFAVMIGPTIALLVAAGTPYDGDWVFLGRWDGFVFKGMYSAVLGLILAPALAIMWMVRAGWIYHQFVGRVPGSSSLSGSAHGTIGGRSIGGGSDVGAWGVLGRPGDARKPGKGLGGRWPGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD73</accession>
    <name>A0ABR3VD73_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57461" checksum="79D44910CA64932D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDD5</accession>
    <name>A0ABR3VDD5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000139">
        <property type="protein sequence ID" value="KAL1839817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="781"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1081" mass="116810" checksum="76913AE44D3CE5E0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDV1</accession>
    <name>A0ABR3VDV1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="226" mass="26966" checksum="68A87DEFE70C73DC" modified="2025-10-08" version="1">MPMNKDRQRRIRNMLHRSLPKEDTPEFELWECNQRLSPLLRLPPELRNRIYELVLDVGQIHVCFKRWEHKARIRNGQRYYETSEGGFFCRILERDQNPWRELKSRKPPSDGSPAPRGMTLLSPVCRQLYHETALLPFRLNAWSFDSLHTMDRYIMKEKRLPLPQRRAIRLLYTQTVLPTPVEKYLGGLEVIVLESGLTMVKQVVESGPEHGYRRVVSWDLHHTKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDZ0</accession>
    <name>A0ABR3VDZ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3',5'-cyclic-nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000142">
        <property type="protein sequence ID" value="KAL1839732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="69597" checksum="649B52C99E1D0778" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE49</accession>
    <name>A0ABR3VE49_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000145">
        <property type="protein sequence ID" value="KAL1839681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="214"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="465" mass="51841" checksum="C5E0925852C513F4" modified="2025-10-08" version="1">MAAAKAEHEVPGTGDVFRTLGLPDKFMVGLDAMAITTSKSLAGFRDIPPGPHFLWAQQPDGVSRCGYWFVTSNTHRTVRVKEWDRYNETLGEPSSASRDASLESVHSDLKPYTLHDRSKNTGSTHWSLGDPLPEWARAPGRLWNALTSAISAEALARITGKKGVDEVFVDSTDTRRDESEPATTSQVDSANSTGLSFLFLQDFRDLQVLDLSGSRSQSGEDTSSRVEALLSRHHDDDDDDDRITEREILAELQFTFLTGTHLGNAACLEQWWNLVLKILLRAYQTTTTRLQFAAGVLRTLHAQLLYTEHYFGSSSDSSEPTTTTIQDRTTTKRDGPSSDRPLFQYKPHNREKLRLALIEYKRRALSGLLSSSPSNNHSTVDHRAVVEAFEELEAWLWRWNWDLRATEAVAAAKTTTTTTAVGRGSSSGKDDMMIMADSDEDEDEQPVVVELDEEGREVGLVSFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE62</accession>
    <name>A0ABR3VE62_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000139">
        <property type="protein sequence ID" value="KAL1839807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="34759" checksum="E90D24DF1CBEE986" modified="2025-10-08" version="1">MEHNSPPPDLKQDSTSSCPSWTLSSPSPIPDAVLRAVHASDQAMYPVDLPYERLRAWIDAAPDLSVYYPPAQPVRNLPPDPEHRVPTTGELVAEEAPSAPTGQGVRVRDGAAASGGDTETCTPARRERAAAGGGVAVVLPLQRRHWDDLLVGKLREAEIDPVCMFPPDGKSEAVEIGGKAEGKEEVGLHVYHIERFGDGLGEVGGGRRAGGGGRESSEKRRPRFSEVALAEVVRRAKARPGWKIVGMSALTATAAGEKTFHTLGFKPTGYREVLVARDMSDPSCASSDEEQRVDMVCVFPGDEMQLGDAVVLSTSKMVVKYDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEH8</accession>
    <name>A0ABR3VEH8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000139">
        <property type="protein sequence ID" value="KAL1839816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="350" mass="39693" checksum="D324C9D4EDC90F97" modified="2025-10-08" version="1">MMCMSHHRDQAVFDIFAIPAMLEAKDEAKEDDDANEAVWIRGFDSMSFARLLPLSILRPSVSALVPQRVTGAAAAAVASDSDVTGSKDDDNKLDVMAMYAEYCRLLRSKVTRRPWRGLFLDITALLEELSFLWVMFETALKRVDKYLEETDTAMKGSSDVQGPFGKPRLARVEHEYMLRERAALNTECQKVYKLIMFTESLQRRVKQMVEVMDEGNDKSIHVFTVVTVLFLPLTFVSGFFGMNTIDIRDIDADQTLYWTVAIPVTLVTLCATLVYAYKGGEIRDKLHEKLHEKSGRSPAAKETGKTEKTKLSIKNRIAAPSERPKGSVRDRIRRRLRREKRTETVGSDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEJ8</accession>
    <name>A0ABR3VEJ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000134">
        <property type="protein sequence ID" value="KAL1839942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="51"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="409"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="775" mass="88006" checksum="2F633C632E3FB70D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFD0</accession>
    <name>A0ABR3VFD0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000118">
        <property type="protein sequence ID" value="KAL1840325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="71639" checksum="E9BE12BD02D71CF0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFL5</accession>
    <name>A0ABR3VFL5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000128">
        <property type="protein sequence ID" value="KAL1840078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="3">
        <location>
            <begin position="163"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="385" mass="42804" checksum="F7EA7D27EAD499A8" modified="2025-10-08" version="1">MMARSGTTVNQGEPITTPEDFVNGEGADAGEALDATTTPSRINRRPMTTKKVTLLAVAWLTILSALRNKRVPLPVRRFIYYPIVLNVVSLGFVDLVEYLLRYISRTGWNWRKFRPALFFWWCSLASLAAAEPWNQALCVQPTVVGTRSDGDPFTILGDAGSSVRMLRVYRSNGRTGYLRGLDVRFSDGVERSQGSRKDQFSELTLDDDEVIQSMTLWATPPGRFFSFFSRGGRVARLDITTNRRSWGYGIDNAAKLAAQAVNVGSGVLVGFRGRSGDDLDQLAPLFLKKLSQSTVHNITYNRPVGAEGLRLLILREGTALWNGTDYSWTFSGTEAWGTETTFNIGSAFIFLVGTRFAVQLPQIGISGFDVQWTYTSTANYEKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFT5</accession>
    <name>A0ABR3VFT5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="312" mass="33118" checksum="AC8B08B53FF81FC1" modified="2025-10-08" version="1">MQAETGTTSLWTERGTTVRGTEAAADGPRASARVGVADADQPAPPEPRRGQAEWTVRKTMRTPSNPNGHRHGGDAAADRRRWRRTSTGRGEPISSARQPVAEMMARGAARIAFARHEAVAAAAAAVSASQQGSGGEPRRVPTSEPDRGSDRRVNRTAGKRAKPAAKPAASEAESAAGPRQETSEQGEEANNEVQNTTTDEMAEGVDTTDTGSTTADLGQLEVEQWLLKVVVMLARVAAAYWQVVSPVFDVESELRQRLESGEPTRGDAVVCVLAVVFLFLVASASVWTVRGVMWFVGLVREVGRVLGAVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFW1</accession>
    <name>A0ABR3VFW1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_214</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF11">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046145745" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1840664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="277" mass="30652" checksum="D1D25893251A45CB" modified="2025-10-08" version="1">MKALLSLTALAALAAETVSAHYIFQQLSVAGTRYPVWKYIRRNSNPAWLQNGPVTDLSSTDLRCNVGGQVSNGTETVTVRAGDQFTFHLDTAVYHQGPTSLYMSRAPGKVEDYDGSGPWFKIYDWGPSGNSWAMRDSYTYNIPRCIPDGEYLLRIQQLGLHNPGAEPQFYISCAQVKVTNGGTTNPTPTANIPGAFRKTDPGYTVNIYNTNLANYVVPGPRVMTGLVEREVPAHLTLSDQARSYMTDKAGLVRAASKFMGPVVFIWHRVFKFTSWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFY2</accession>
    <name>A0ABR3VFY2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000107">
        <property type="protein sequence ID" value="KAL1840583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="608"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="78858" checksum="D72FE51158A6D3EF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG60</accession>
    <name>A0ABR3VG60_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000110">
        <property type="protein sequence ID" value="KAL1840497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="201" mass="22144" checksum="78155E7703317DB5" modified="2025-10-08" version="1">MSDQQQQQQQQPITTAAPATPAAPAKPSPINPEDVAHWSARFNEVLAKPSETFNSKSPQGAQPWYHSFFNCLAPIETCLLSWCCPCVVFGRTHHRLHRNADLQGWEPVNASCLMMWASGCVCLHWLPVAMQRAEIRTKHNLQGDFLTDVALACCCGCCNIAQADKEAEYREKLLAGNQGQQQGYQAPAGMSYPAQGEGKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG84</accession>
    <name>A0ABR3VG84_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="55"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="137" mass="15637" checksum="FCF9C360A29044F7" modified="2025-10-08" version="1">MEKFSPSQVGRGGFAQAMRLAGFIGAAGGFLYFYQRSILRFYGMTENAREVEMDMREMVDKVKRGEPLYGESRLIPAMQGVAARQSRYSALFFSVLPWFNFVNHSQHGVDTAKYYQQAERELEAERLARESGQSQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG88</accession>
    <name>A0ABR3VG88_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="9">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="9">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="9">PHB:PPT</shortName>
            <shortName evidence="9">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="559"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="666"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="843"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="914"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="982" mass="104553" checksum="19E79CD6D9A53152" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGU8</accession>
    <name>A0ABR3VGU8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-galactosidase CBM13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055240">
        <property type="entry name" value="CBM13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22704">
        <property type="entry name" value="CBM13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045674492" description="Alpha-galactosidase CBM13 domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-galactosidase CBM13" evidence="6">
        <location>
            <begin position="363"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="451" mass="49915" checksum="20DD3F2C61875141" modified="2025-10-08" version="1">MRLLSITLAATLSRLASASLQIVPGATWTTPDGEHLQAHGAGMIQENGTYYMIGEDKSGGHSFTNVNCYASTDLVQWTKVGALLSRQASGDLGPNRVVERPKVIYNDRTRKYVLWMHMDSSNYGEARVAVATGDSVCGRYQYHRSFQPFGRESRDMGLFKDDDGKGYLLTEDRRHGLRIVALSDDYLNPTEDIFSWRLEGGNRVEAPAMVKLGNTYFLFASMMTGWDANENQYTTATNLRGPWAPWRKFADAGSRTYNSQTTYILKTSESSAIYLGDRWEKDNLMASTYVWLPLHISGTSVVMKNFVNWVPTNNPSAWQSGIAETTYEGEQASYGGRARTVDCSTCSGRRAAGYIGGPDRGSVTFTGIRSDIDGLTTIRIKYMNGDSSPRYAWVRVNGDAGRKVAFLTARGDPASSTLHANLRRGNSNTITIEGWNGGWGPDIDRLMVPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHN4</accession>
    <name>A0ABR3VHN4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000105">
        <property type="protein sequence ID" value="KAL1840616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="559" mass="59033" checksum="82342CCDF862DF14" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHS1</accession>
    <name>A0ABR3VHS1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="228" mass="25539" checksum="72C8A37823D51058" modified="2025-10-08" version="1">MAKNHEQKAAKNPTVWDNDAHLALLNAVMAEAPPAPHEWDRILARVAEKGYHYTASAAIASPTMASARMTWDQTADHHLMLALVQELAPGQDQLEGVRLRMHEFGHKCTVKAITQHLQKLRRKDEAKKDGDGSATTPKPGRKRATKKEPGSSTTKRKKGAANPEDDDESVETPSKKPKVKKEADIKQEPDVKEESDDDDIVKVEDSDEYVITFSYLLMTHSNLWNQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI38</accession>
    <name>A0ABR3VI38_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="483" mass="51297" checksum="73AAE8FEC5BFF8FA" modified="2025-10-08" version="1">MPPSLRAKSINVYARWRPLTASEGATGEISRSTVANDKSLSSITISRQTLGPYSSWTSPPVFTAVFNPEDDNSAVCNTTVAPAIPKVLEGGTCTFLASGPSGSGKTHTIVGDGQDSDGGMSFAHCPEPSVMPPSLTVSSVSVALRACRLAVRGSRFARCAYSTATSNDANNGPLVRTIDLPAPNSGHIRILELNRPAARNAISRALLASLRDEIDAVHAQYDPATGEEVPTPSWEKRFGGVAGDDKKGPTRALIVASAVESCFCAGADLKERKGFTQEETANFLHSLRSTFTSLSTLPIPTISAISSLALGGGLELALSTHFRVLTSNAVVGLPETRLGIIPGAGGTYRLPALIGVPRARDLILTGRRVSAAEAYFMGIADRLVEVAPESEEQEKEWEALKDDAEREKVILAAARRAALSEAVRLAAEICEGGPVAIRAALKAVEEPCESVENSMYERVVKTEDRDEALKAFAEKRRPVFKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI86</accession>
    <name>A0ABR3VI86_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF41">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="8">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="250" mass="27258" checksum="AC5BD802466B6F80" modified="2025-10-08" version="1">MAKKHFTKIENSPHAMNALAKELGLSDDLTFYHVYSLDEPDLLVHIPRPVYAILAIIPLTPAWRRDREAEDAALGDPESYYRGGPAGTGSEPIIWFKQTIPGACGSYALLHSAANGAASRHILPGSTLEKLRDAALPLDRTERARLLYDSEEFERAHQSVAALGDTQLPAVRTGERAGQHFVAYVKVNGHLWELEGSRDGPLDRGKLDEGEDVLSPRALAQGLKRIMQLDTDAGGGDLRFSCIALAPRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIH7</accession>
    <name>A0ABR3VIH7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="116"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="233"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="505" mass="55998" checksum="52A54F9118B8240F" modified="2025-10-08" version="1">MSNIDRYRPPREGYQPPSLPAKPVPPAISRLSRSPSRRRDVPPAVPSPPTQSSRTSPPRPQSRRAAPSPSQSSPPRAPQARPNQWWFTADEVRSTPSIIDGLSIAEERLRRAKGVNFIYQAGIMLELPQPTLWVAGVFFHRFYMRFSMVEEKGGIHHYNIAATALFLANKSEENCRKTKNLIIAVAKVAQKNIRLVIDEQSKEYWKWRDSILAYEELMLETLTFDLMVDQPYRHLHEMLGHLNLLHNKRIRDAVWAFCNDACLTVLPLMLTARDVAIAAIFFAATTTKEKIDDVQGEPWWRHLRASETNAINAVRLVCEFYKENPLRKQDAKEVPGSPEFNLESTRRRGELSLSQLDLDTSQRGSSVTPLGGGTDRGGTQSPRPAPAVLVNGRADAEDAAPAAKEKEEQQPPEPPSSSVKMEDGPGDSDAALKAAANDLSTHDDRGGGGGGGGGGVNDMPEEGLVSPRVPKRQSQDPEAGDSQDRKRARLEAEREEDMDEGEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIR4</accession>
    <name>A0ABR3VIR4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6616</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000064">
        <property type="protein sequence ID" value="KAL1841778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="261"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="930" mass="106111" checksum="1F71CDE066B9FC4D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ81</accession>
    <name>A0ABR3VJ81_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-splicing factor syf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="76"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="10">
        <location>
            <begin position="239"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="454"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="818"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="103445" checksum="5BD6F3A84CF4A8FD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJA6</accession>
    <name>A0ABR3VJA6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10405" checksum="D39C662E13328FA9" modified="2025-10-08" version="1">MTYKTWQDKLNEACREYNIAAPVFQIVSDRRGGRTAWSSRVNVYGAVHSARFWYDGKNLNNAKEDAAEVALMWLNGGQSSSSAASSPATSRGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJE7</accession>
    <name>A0ABR3VJE7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
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        <location>
            <begin position="66"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
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            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="530" mass="57727" checksum="8D87C4C6629D5298" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJG5</accession>
    <name>A0ABR3VJG5_HUMIN</name>
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            <fullName evidence="4 5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">VTJ49DRAFT_7450</name>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
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    </dbReference>
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        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
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        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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            <end position="296"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
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        </source>
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            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1841066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="365" mass="39747" checksum="FCCA72C8D19E8C33" modified="2025-10-08" version="1">MTRLSLAGLVTVLLAGAASADPVLDLQNQGRPQIDAAIAKSSKCTKEKLQAYIAAMLCIMSKPSKLDQTQFPGAKSRYDDFVVVHMNQTMTIHGTGNFLSWHRYYTWAFERALQTECGYNGTQPYWDWSRWYQDPESSPIFDGSDTSLSGNGEYVQHTTTGGIPVGNGGGCVKTGPFKDMVIRLGPMAPVINPAPPRNPRPDGYGDNPRCLRRDMSNKLSSTSLRPQDVASLITGTNSIGAFQDTMQAVGGFSWGGAPSTMGVHGAGHFTISGDPGGDFYTSPNDPAFYVHHAMIDRVWYIWQSLNFESRQQVIAGGTSMMGFGSPLATLNDDVHLGPKGLMADEVYKIRDLVSTVDGPFCYVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK39</accession>
    <name>A0ABR3VK39_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36035" checksum="0B35EABAA9D695CA" modified="2025-10-08" version="1">MSCPGGIPDWSGVTLETFNHTLLENPLLCTLCTCPLEIDGYMVAYMGYVPSLGGNVFFTIVFGIALLFQLYLGLRHRTWGFMIGMGGGLILEVVGYIGRVLMRDAMFEDTYFIMSLVCLTIAPAFLAAAIYLSLSRMVVIYAPERARFRPQVYTYIFIIGDFIALLLQAAGGAVASLADPGSDLQNAGINTMIAGVAWQVFVLLLFGALSLDFWLRGARVAKKNGTLNPTFAHLRARKAFQPGFVVGVFLAAAFVFVRSVFRCAELSEGFDGPLANDEVTFMVLEGTMIALTSILLTVAHPGVTVGKEGWQAASWKANKKAGDAEKMVSDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKC0</accession>
    <name>A0ABR3VKC0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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            <begin position="23"/>
            <end position="419"/>
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        <location>
            <begin position="340"/>
            <end position="351"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="419" mass="45745" checksum="39EB9B85B7B718F5" modified="2025-10-08" version="1">MLSKWLLGTAVAVSTLVPASVAAPGPKKADLNTINLLKDSLPPYDPSQDEDGFLKLTYDAVANLVEQKKNLGKGKGKGKGKGCDLTKVKVRRNWKTLSNEDKKKYTSAINCLHSKPSRYDPAVVPGALNRYDDFVAVHIIQTRTIHATANFLHWHRYFIWLFEEALKEECGYNGPFPYWHWPDTASQPYPSIVFNDDEFGLGGNGENIPHNPNGTPMGGGLIIIPVEGSGGGCVTTGPFANFTVNLGPIAPTLDLVPPAPETLAANPRCLRRAISQWTASTWTTAPHITDLLVNPAYATIGPFQNRLQGDFPNLYPGVHAAGHFTIGGDPGGDLFAAPGDPAFWVHHAQVDRVWWLWQLLEPSGARFNQVAGTITMLNNPPSRNGTLEDVIEMGAITDVTYQMKDLVSTVDGPFCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKH3</accession>
    <name>A0ABR3VKH3_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">VTJ49DRAFT_6234</name>
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        <name type="scientific">Humicola insolens</name>
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        <lineage>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1841991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="NDT80 DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="175"/>
            <end position="465"/>
        </location>
    </feature>
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            <end position="465"/>
        </location>
    </feature>
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            <end position="183"/>
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            <end position="346"/>
        </location>
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            <begin position="668"/>
            <end position="698"/>
        </location>
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            <begin position="118"/>
            <end position="128"/>
        </location>
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            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
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        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
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        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
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        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841991.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="698" mass="75493" checksum="2F5374F8C4B4B2D0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKN7</accession>
    <name>A0ABR3VKN7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
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            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
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        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="516"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="542" mass="59614" checksum="96AAF2CE4D7CE48C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKV2</accession>
    <name>A0ABR3VKV2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
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        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="97" mass="10225" checksum="57E52CE5E39DEE02" modified="2025-10-08" version="1">MADVETAAAAPAEHTYEFNVTMSCGGCSGAVERVLKKLEGVKSYEVSLEKQTATIVAEDSLAYETVLKTIAKTGKKVTAGKADGEERSVEVPAEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKW4</accession>
    <name>A0ABR3VKW4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="WLM" evidence="10">
        <location>
            <begin position="1612"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="889"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1158"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1282"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1417"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="889"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1164"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1285"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1419"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1472"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1505"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2084" mass="232922" checksum="9134709C5949EA19" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMB2</accession>
    <name>A0ABR3VMB2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">superoxide dismutase</fullName>
            <ecNumber evidence="2">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="8">
        <location>
            <begin position="157"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="262" mass="28589" checksum="470D0AF936C1A35A" modified="2025-10-08" version="1">MPAPHLVADGTTFTSHSLEGYRKSFWKNPAMSSTLFRAGPALRGALRASAAPRVGAMASTGFVRNKATLPDLPYDYGALEPYISGRIMELHHSKHHQTYVNGLNSALEAIAEAEAKKDFTKAASIAPLLNFHGGGHINHTLFWENLAPASRDGGGEPDGALKKAIEGDFGSLSTFRSQMNAALAGIQGSGWAWLVKDKAANNLQIVTRANQDPVTGTFVPLLGIDAWEHAYYLQYENRKAEYFEAIWNVVNWKTVAKRFESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMD8</accession>
    <name>A0ABR3VMD8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="250" mass="27610" checksum="12929D5C6F96838C" modified="2025-10-08" version="1">MTLAHAFAADDYARYLVDIDHGHGHGGGGDGDGCGLTPKEEARRWRLHVDILAYTVAAHCMGGLVTAVGPEFDSVAVWIPPGKNLDGLWTHFRSGLWRLHFKLSAEGRRRYYDEILPLLHDTKAAVLGPRDADAWYLVYLGTKPGSQGRGYAARLLRDVMARADAENRPMYLESSSPANNAYYEKFGFRVQRDIYLQRGSAPVGLSIMVREPGGAVPTAARTTYQGTSSSLNSNEIVKKRRVGIKRLMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMH3</accession>
    <name>A0ABR3VMH3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="429" mass="48221" checksum="6D6022D4630FC083" modified="2025-10-08" version="1">MSPAAKDTPEANSGSQSNKSATRNWIMGAEAFERRMPHHDGIKALWETKWKHPCSLSVYPFHDGAYEDFEPIFRELIEENITTSTSPAYTQTFLPIARLLASHADLAASQGDRALATSLYLRACAVYRIARFPYITSFPAINDKDKWIAWEEQKRTYLKAGQVWEGAKLEEYCVPHRWRKEGDRDGGIWVYVRVPVAEKDGGETGKKVPVVILMTGLDGYRPDNTVRCDEFEKRGWASVVAEIPGTADCPADSSDPEAPDRLWSSLLDWMEEDSRFDMGRVAVWGLSSGGYYAVRIAHTHRERLAGCVAQGAGTHHFFDAEWLDKAEGHEYPFELLPALATKHGFTSVEEYKAKAMKKFSLLENGILDKPSTRLLLINGTHDGLMPIEDSILLFEHGTPKEARFFTGALHMGYPMANSSVYPWLEQVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMW9</accession>
    <name>A0ABR3VMW9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="279" mass="29717" checksum="7D5AC729CCB5C8EB" modified="2025-10-08" version="1">MAGPTRRRGPAAFQKAPTVARCISHRVLFRSFPAAVRPLEILLVLLAGGLRALLITLGVDGLGEGVLELDGDEVHGQDVQRQKEAGGLAVQEGSAEEAHGRAIVHRGVGDVEGEARHDAVHEDPEVVAQVGAGDAQLVGGRDDEDVADGQEGIGDVLGQVRLEGWVRGLVAQGALIEVVAEEAEREDGDGEGVACQLAVAPEEAGEELGAVFWEVLGYYWLAERWWVHLGMRTSASNDAGRRKSARENYSRQSPANLLPEGRVKGNRHSRDCCGQHGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN29</accession>
    <name>A0ABR3VN29_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DSC E3 ubiquitin ligase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32218" checksum="DFA92198D8A259F8" modified="2025-10-08" version="1">MSFASTPVTRTLVLGLVGSSIAASLFDIKHYFYISVGTHILQYRQTWRALIWQLCYTNSSEVLFAAMTLYNLRVVEQLWGSRKYASFVLVTGLLSSIIPPVLLTAVIRPLTWGVFDFLPAGPTPIIFAILAQYHAMVPHIYQYKVALSTGPPPSRTGGSSSSSGNNAEDVPGLVFSDKSTKYLMALQLALFQWPGSLLGAAVGWLVGQAWRSELIPGALTRWRVPGWVVGMRSVKSGSSDRFEGMRRRLESEGASTGATASGLQQQQQQQQAGIEASRRRTMGQQLLDEVRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN82</accession>
    <name>A0ABR3VN82_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF16">
        <property type="entry name" value="BACILYSIN BIOSYNTHESIS OXIDOREDUCTASE BACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="383" mass="40894" checksum="5F562943C24045BA" modified="2025-10-08" version="1">MSAPSIDDPWSVVYMTNLSGPVDLSKSYNPSSLAGKTILITGGASGFGAAFARHWAAHGAHLILGDVNDSLGEALVAELRASPTTRADQFITYQHCDVTSWADQVSLFRAAVSGSPTKRIDAVVAGAGIVDSNASFDQPQNLDDETTIPPPPPLRVLAVNLTGVMYTAHLALHYLAQDSTTTSGNRDRHLLLISSIAGLLGLPGQTEYTTSKHAVMGLFRALRGTAGLLGPAPERNDTPIRVNVLCPYFVSTPLISRAGMALLAGAALGKLEDVVDAATRLMADDGIRGRALAIGPKMRVVDIAEGDEYGETVQMVESEPVVPGRSERKQAVWEVYGHDYRRVETFTWRYMAMLNLMTGLRGWVGFVKDLLGLCFGGAGSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNH3</accession>
    <name>A0ABR3VNH3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053949">
        <property type="entry name" value="SBE2/SBE22_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22874">
        <property type="entry name" value="SBE2_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="474"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="745" mass="81815" checksum="2B817A72C67CF140" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNH6</accession>
    <name>A0ABR3VNH6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="577" mass="64545" checksum="1D31938447477756" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNM8</accession>
    <name>A0ABR3VNM8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF80">
        <property type="entry name" value="GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045871561" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="627" mass="68104" checksum="E17B02C85F19EC45" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNN2</accession>
    <name>A0ABR3VNN2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="319" mass="33964" checksum="0C8E9099E78229FF" modified="2025-10-08" version="1">MTGPRTKRQFAGAASDPSQRSITSFFKTTSSTSSSDAAALKPSKPAALNGPALPPQIQTDLLNVGMRVRKAVPEGYKTGSTYSGFTLWSEENNNTTATATATNNDWPATTPAPAATTYSSSVRELEPFCGINKIGGLAFQPAHPHGRAHDDDDNDDDELTLDMDAMPGLTSSQDTVASTASLSSIPQRTATTGTTRKRSFDPEEDEPASNASFLAPLPYRGPVRRASDSPENWLDDEISPRSLAPPPGLWENARVLAVPRRPRSSLQKPAFAPSSVGSSAAGQEENVMVVPARGIDGNDFEEASFLDYGLVGDTRMDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNU5</accession>
    <name>A0ABR3VNU5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane fusion mating protein FIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016509">
        <property type="entry name" value="Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007138">
        <property type="entry name" value="FIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29230" checksum="3A3C174BF55E8ED2" modified="2025-10-08" version="1">MVDTERFRLGWYRWLPFLGYHHVLMILIAVAIILLSLLLAGCSSSSPMIPDIFLLSLYYERYTAVPDTAQVDYNVHNAIANIVGGARLQARVGYFGICVSPDGGAWLCSNNATSLANEISVDQDPLNLVWLASQFKDMIVFPYLLIIAIIFAFICLLLLATFPGWHEEDTGEGTEREIKPFPSRPVSQVALAIIFIASIFVLVSVLWQHTASVAASITAQDLANGSVLSGVGSSAMVMGWFSFTLLIIVTIGERLRHTGNGNVYGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNX8</accession>
    <name>A0ABR3VNX8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045477672" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35355" checksum="B1FB22213E595B77" modified="2025-10-08" version="1">MPPLAILRFLCQSWVVSLSLLAFDSRALGRAEEEGVINCYYFDGRISPNNTRCPDSNTCCPPNRECLSNRLCRDPADGENNWIRGPCAVKGWDGACAQICLYDEPGGRFPRVTECADGSLCCSNEPWCCQDKKGVFLDQNGNIIATRATAPTTTYVVVGTGLSRSPLPPAPEASASSTLNSADTAQTTPVTNNDDERPTATDSSAALDSSLPPSSPTSSVTSPESSESDSTLGLRLGLGLGIPLAVLVTACIAYFGMRLLGWRRSTDAAPHERGDADVASSSYYMYGSPPPKEPVPLMRYPVELMGHEAGELDGQPRGELCLRLCGLQLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNY4</accession>
    <name>A0ABR3VNY4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_1139</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057211">
        <property type="entry name" value="DUF7889"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25417">
        <property type="entry name" value="DUF7889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="881"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="931"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="978"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1037"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1274"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1315"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1372"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1496"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1572"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="17">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="359"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="464"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="513"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="615"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1843546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1630" mass="179035" checksum="1B8444FE7772E0F6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP81</accession>
    <name>A0ABR3VP81_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="335"/>
            <end position="537"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="397"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU367067"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843577.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
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    <sequence length="576" mass="62268" checksum="B512DAA9A5D075D2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPE2</accession>
    <name>A0ABR3VPE2_HUMIN</name>
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        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">VTJ49DRAFT_7487</name>
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        <name type="scientific">Humicola insolens</name>
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        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51797"/>
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        <source>
            <dbReference type="EMBL" id="KAL1843777.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="170" mass="19027" checksum="081BB49608C256A9" modified="2025-10-08" version="1">MIIYKDVITGDEIISDSYNLKEVDGIVYEADCAMITEGAVEVDIGANASAEGGEEEAVEDQAVKVNNIVYSFRLQSTSFDKKSYLTYLKGYMKAVKAKLQEQGKSEEEIKDFETKAGAYAKKILGSFKDYEFYTGESMNPDGMVVLLNYREDGMTPYVTVWKHGLTEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPV8</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
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    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7212</name>
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    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="52682" checksum="C223509E5415BDE4" modified="2025-10-08" version="1">MTSPPSTVAASAGDTAVASQGTFTRSLGTAEAFAVVVSIVIGSGVFTSPGAIDTNVPSPGVALLVWLIGGLLAWTGANTMAELGTAIPGEGGVQPYLTHIFGDVFGFLAAWTWVVAVIPATLAIMVTVFVESAYAAAGVTTTDGAPLSHKLLAIAVLIVITAANSVSTRVSTRLNGVFVGAKFTAIALVVLAGIVVVALHLAGRDVGGGDWISRSWFAARDSVNPDGSVTHWDELGVWEILGHLSAALYAALWAYSGWDKAIYISAELSNPVRQLPLAFNTALATVLVCFLTANASYYVLLPWDVVSTTDSVAVAAINRLLGPGFGIAAAVLICFVVAGSLISSYFVAGRMIVAAANRGWLPELLGVVGHIGTTKPTPEEYGTSDSPSPDEPSSPSDAPINALLLTTAATAVYILVGNFRALLTFNGLGEYTFFFLVVVGALVLRWREPELKRPYKTSIANPVAFALVSGFVVVRGAVFAPTQALALLGLWALGLGYYWVRRRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ15</accession>
    <name>A0ABR3VQ15_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="123"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="460" mass="50982" checksum="2A6485559630BC3F" modified="2025-10-08" version="1">MALDDDDNPSLTPSETTMTTPTPSNGGPAAAADEQMTAEELLEDEGGSAAQDFRAFATALQHQKNQFRKEPGVSAQTIRRGEKDFESHGTRAQADALEQSRAAMRDVLSYVRVHPVPSGAGASRGKVGSNPVRGWYFPGWWEGFEEVEEEEVVVKGEDGERKEKKPYGWIRERVVVLEGSSTASQALGRAVTGQAKDRPARGKDWLLPEEALYLVERGSLDLWWPFKSLEELFPSEVAAKEAQETGEDEEKEVDEYDLGIPLSLQAAYALLIGDDGERGKISLQKFQVYSNLKRCGYNVLRAPPLPKQSTQSPSSPAPRQTLWQWLTSRLTSPSQPPPYGPLVRPGLYRSYVPVYRQMALIPRHSPSSSTSTPSFQIHYHVWKSAQKWTKLRHPPPDFRLAVLDAQQTFVPSLREIGSLLDSSPADRGNPQWAGHPGRITAPVLLRSHAVSLRLGIAVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ87</accession>
    <name>A0ABR3VQ87_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="7">
        <location>
            <begin position="196"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="6">
        <location>
            <begin position="869"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="5">
        <location>
            <begin position="1202"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="916"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1446"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="955"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1117"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1525" mass="165661" checksum="1BFFA1D2B79BE669" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRA5</accession>
    <name>A0ABR3VRA5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="287"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1844174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="555" mass="61410" checksum="2A1FB5477EA230D3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRD0</accession>
    <name>A0ABR3VRD0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1217" mass="132038" checksum="660D1F00F2FDB0AC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRH5</accession>
    <name>A0ABR3VRH5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1993 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19949" checksum="46EAF362A8008CBD" modified="2025-10-08" version="1">MAAIPLYDATIGLAKQSLETLRDLLVKAQAHPEAASLAQARLIDDMLPFSFQVQTVSNFAKKTVERLTGRDLGVWEDNETTLEQLAARVQKTLDLLDTVKPEDLVKGGADTMHELKFGPNFTLPATTHQYVLGYYLPNLLFHLSTAYALLRSKGLDIGKRDYLKNFVSPFFPAQEPAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRR6</accession>
    <name>A0ABR3VRR6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_33</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="380" mass="41178" checksum="3E25AFE53325FBE9" modified="2025-10-08" version="1">MLAVIDLHEKQKEMRRQIIKQLRGFFALPRPITPSMQVRESLLYRRSLFSSTRLRLTSLQQRVANTTNLAFNLVTQQDSRLMVRDSASMTVISFLTVIFLPTVSVATVVGSQLFQTEYDPFPDGTGTQTTVYTSPLFATLWYFAIPITVVITGIAVAYRMWVLADRKLAVEQILGRIKGWWPRLARKQRSPSPEDGGPPYDPAKYHPELHGGDGATRMQPESRVVMVPLSSSVGSVPSQGAGSGESVLGQPAETASKERDVLMRPDGDGKTQDASGAYATVSHDGGGLPPVQPGSSVVPEPPRSIGGGGVVGVRLATVEQVVPEPPSSIGGGGVVEVRLPTVEQVVPVRPGGSRAYARGVRTVEDLAGRNFQESERYYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0M5</accession>
    <name>A0ABR3V0M5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-assembly protein 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000744">
        <property type="protein sequence ID" value="KAL1835319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="78" mass="8463" checksum="CACC625040B094F5" modified="2025-10-08" version="1">MAPQPPSPSPTPEKSDKEVAAEFTSYYLQRATKEFAEDLDKNDALHVLIGALQQGTALFSPEEQRRIVTTAASSTRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V146</accession>
    <name>A0ABR3V146_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000640">
        <property type="protein sequence ID" value="KAL1835484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045007522" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1835484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="383" mass="40985" checksum="6426BDF35D454417" modified="2025-10-08" version="1">MLFSTLASSLLALVSFADATPLVKRATLTRVNNFGNNPSGARMYIYVPDRLQSRPPVLTAIHYCTGTANAFYTGTPYARLADQHGFIVVYPESPNSGGCWDVSSRAAYTRDSGSNSHAISLMTRWALEQYNGDPERVFLAGTSSGAMMTNVMAAVYPDLYKAGAAYAGVPAGCFYTGTVAGWNNTCANGQSITTQEHWARTALDMYPGYTGSRPRMLIYHGSADTTIYPRNFNETLKQWAGVFGYTYGQPEQTLPNNPSAPYTRYVYGPNLHGIYGSGVTHNIAVNGANDMEWFGITGNPPPTTTSTTAAPTSTSTTSTSTSTSTTSTSTTSSAASTPTLPTNPGCTPVGKWGQCGGMYYTGCTVCEAGSTCRFQNDWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1B2</accession>
    <name>A0ABR3V1B2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000636">
        <property type="protein sequence ID" value="KAL1835494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="67" mass="7582" checksum="441400BB3080B86C" modified="2025-10-08" version="1">MYWWFPPRFKVAKTVVLQKPVKPPATYRAPFGYRPIDLLPTIGEIIEIVVATRVTGAAEANDLLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1B5</accession>
    <name>A0ABR3V1B5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000600">
        <property type="protein sequence ID" value="KAL1835575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="432" mass="43284" checksum="5BE09369FA57CD39" modified="2025-10-08" version="1">MTTTTSVETDAPESTGSSSTVPTESTTTTASVPVESEISEDPEESENEEILTSTTSAASVEPTGSDIPTITKGPDAISSTTTNDAASSTASYPPEEDDDEACDDDEGEEEDEEDETSTSSSSTASVAPSFTASASPSFTESANPSFTESANPSFTESANPSFTESANPSFTESANPSFTESANPSFTESVNPSFTESAYPSETSSTTTSSAAPTETANPEDDDATDPDDIDEPSPTATASISSFLPNDNNPGGGWTTSTIYSTTTYTITSCPPTVTKGCTTGSIVTKTIAVSTTVCPIMTTTTSSSSSDENDDIATATAPPVPTVTGPSGGDDNDDQEEDGSEETESSSSSWFSTVTSTSTGFTTLTVSNKPEGTGPAGSAIPIVTTGGAVKPSASASTSSLPPVVTAGAGRSAVVGGGGVVAAVAAVVMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1E4</accession>
    <name>A0ABR3V1E4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000597">
        <property type="protein sequence ID" value="KAL1835587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="348" mass="38018" checksum="552B0A5FCB35EE8B" modified="2025-10-08" version="1">MATVPQLRLASLQGHNLRSNITLKARPALLKRHFGVLPSVAQSRSGSFISPSTFTSPRNPGSWWTRSTRPSSDLATSLRIGRRTFSTQPTRKTSQQDKQEYQPLPDEQATGPTEPPPAGGKAAYPDRLIIYHAGTGRTTFLACLKVTTLFIFGFFDLIMTPAYLAAGEPLLKTAGVALCGIVPAIYVAWTTTPFVAAVHVHLPPYARWSRAILERFARSAPPNTRIDVTTMSLIGKPRVSSMVLSDLRPAVVVPRGDAPGKSGPWDRLRGNLARRLGTVNYVRDTTAADRGRKWWRFRAVGQFFIREDAVDSVKNGWVWKELCEGIAKRAVAGEAAAAAAKGKGKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V217</accession>
    <name>A0ABR3V217_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi pH regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000547">
        <property type="protein sequence ID" value="KAL1835749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="5">
        <location>
            <begin position="133"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36068" checksum="F79C2FE19434EB06" modified="2025-10-08" version="1">MALLSGFASVSSPWHTFVDDRLYRRRPITDADIARKQAGLDAASELLLSKRHRLRALQRKAELVGAGSANGGAAGTTGMVGKVLGSLRGIAGGGGDAAEIRTLQMEIAGLETMESNLASSLSNLRTRKAAHARDGTTLGLLLSIPRYAFATYCLYRILATLLTTLRRAYYPWAAFSSSDPINRFLALLARHWDPSLDVAAWARQISFLLSGAILAVSASSATHTARLFARWAPPFLLLRQAAQANLPLLIAQVVATYVISAALMLRGNLPRDVGRSVADALEGALDPAFADRWFESWFLVAGAGTALGIWVGRKVGGGAGDDDWDDFGGEEMGQKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2J4</accession>
    <name>A0ABR3V2J4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000486">
        <property type="protein sequence ID" value="KAL1835995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="415"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="837"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="871" mass="91542" checksum="DB0C1EF7BC29A713" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2J8</accession>
    <name>A0ABR3V2J8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000504">
        <property type="protein sequence ID" value="KAL1835929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="5">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1835929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="635" mass="69365" checksum="6E91B8A5103A02BF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2P0</accession>
    <name>A0ABR3V2P0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000475">
        <property type="protein sequence ID" value="KAL1836040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="208"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="620"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="699"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="996" mass="110635" checksum="F4D53A5CECB19FC9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3G4</accession>
    <name>A0ABR3V3G4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000531">
        <property type="protein sequence ID" value="KAL1835818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="131"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="872"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1211"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1142"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1247"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1552"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1552"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1570"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1618"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1641"/>
            <end position="1652"/>
        </location>
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            <end position="1834"/>
        </location>
    </feature>
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        <location>
            <begin position="1835"/>
            <end position="1844"/>
        </location>
    </feature>
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            <begin position="1858"/>
            <end position="1869"/>
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        <location>
            <begin position="1881"/>
            <end position="1907"/>
        </location>
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        <location>
            <begin position="1926"/>
            <end position="1936"/>
        </location>
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        <location>
            <begin position="1943"/>
            <end position="1957"/>
        </location>
    </feature>
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        <location>
            <begin position="2026"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2109"/>
            <end position="2119"/>
        </location>
    </feature>
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        <location>
            <begin position="2127"/>
            <end position="2136"/>
        </location>
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        <location>
            <begin position="2213"/>
            <end position="2232"/>
        </location>
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        <location>
            <begin position="2280"/>
            <end position="2293"/>
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        <location>
            <begin position="2307"/>
            <end position="2413"/>
        </location>
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        <location>
            <begin position="2427"/>
            <end position="2437"/>
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        <location>
            <begin position="2438"/>
            <end position="2450"/>
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        <location>
            <begin position="2458"/>
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            <begin position="2502"/>
            <end position="2511"/>
        </location>
    </feature>
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        <location>
            <begin position="2512"/>
            <end position="2521"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2521" mass="279678" checksum="0C327101235D90AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3H7</accession>
    <name>A0ABR3V3H7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000458">
        <property type="protein sequence ID" value="KAL1836147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3I5</accession>
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
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            <end position="204"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1836006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="342" mass="37017" checksum="69550DFCE1893578" modified="2025-10-08" version="1">MANTNGSETATSFADEPLIYHNLMEWLKEQQANRRSLSDLQKKAISTLLTLPPTEPGIGDSNWVGLLNSFSQSCGAIIDFKADSENDFGGNPRHTCVCEVKLSPSSGLLTFPRAEDSPPEERANGAWTLPTFTRRKDAKQYAAKCAAEYLMREGLIVFTETGAPKFPGTKKTKAGRSSGKNNGSTTNNNDKNVAAKKPADDGPHVTKRVEELCHKLGLSFPQYRISPSADQSTTTNYGMEGVTPAGESPNQQFFDAHAEWPPRDALKVPRGLGRVTRVYGRRNARERVAEQVLEWLVEEEGRRMREVEELMAAMDGATGVAGAGAGTGATKGQVVVVEAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V481_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_5225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000418">
        <property type="protein sequence ID" value="KAL1836387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="625" mass="68540" checksum="A1B4C5D5360B82FA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4K8</accession>
    <name>A0ABR3V4K8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1836381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
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            <end position="196"/>
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        <location>
            <begin position="216"/>
            <end position="238"/>
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            <end position="370"/>
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            <begin position="425"/>
            <end position="442"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
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    <sequence length="518" mass="57435" checksum="6E7916EA10F29DC7" modified="2025-10-08" version="1"> </sequence>
</entry>
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            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Drula E."/>
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                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Riley R."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34492" checksum="49EE916E28C4863A" modified="2025-10-08" version="1">MALRFYPNRNGYQPFRHMPNEIIILIGKHCANNRTLSCLSRINRRFHTLLFSELWLTGANDRPGKPALYWAIEMNDLYIAHRALKYYDQLGERAKGILEGTTVLFDTFTWLPGGLENYAYMLPASFMPLSPLMRAVRAGWGIEELRILYYGGCPVDVRRRINMPNYPAKGGGLHTTCTKTVCQERFKLSGTEHLPQGDDDDQWTGPRCEDVLHDAIAVGRPYILEFLLGELNAEPGKLGRPDEPLEMPGDSRMPLGQYLLDTYLGVSGPLVPGLPPPPILDVHDKMITILERRGFNMGLYFPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V552</accession>
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        <recommendedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Nguyen T.T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000315">
        <property type="protein sequence ID" value="KAL1837234.1"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
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    <keyword evidence="4" id="KW-0813">Transport</keyword>
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            <end position="271"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1837234.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
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    </evidence>
    <sequence length="756" mass="81814" checksum="B68B97F50F980AB1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V690</accession>
    <name>A0ABR3V690_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000344">
        <property type="protein sequence ID" value="KAL1836966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="648" mass="69966" checksum="CAE7068BA8B77390" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6M2</accession>
    <name>A0ABR3V6M2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3 12">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_3805</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3 12"/>
    <dbReference type="EMBL" id="JAZGSY010000297">
        <property type="protein sequence ID" value="KAL1837413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="125"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="14">
        <location>
            <begin position="368"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1837413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="570" mass="63082" checksum="A6C0771DC555CC26" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6R8</accession>
    <name>A0ABR3V6R8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">VTJ49DRAFT_4191</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="JAZGSY010000322">
        <property type="protein sequence ID" value="KAL1837161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAL1837161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="379" mass="42967" checksum="E72B3B434B935538" modified="2025-10-08" version="1">MPSRTLPTFTRAEVAKHNSAKSCFVTIGDNVYDVTDFLDSHPGGADLVLEYAGKDIKDILQDPSSHAHSDAAYEVLEESLVGFLASSDDSKGGSTGLENGAATRTDAKGRPIHPRTGMSCEEDLTKDTDIASDYKTHRFLDLSRPLFPQVWNGGFTKEFYLDQVHRPRHYRGGASAPLFGNFLEPLTKTAWWVVPMIWVPCVSYGLYLAYPGFENKAGQVVCFAGGVLLWSLIEYVMHRFLFHIDYYLPDNRVGITLHFTLHGIHHYLPMDKYRLVMPPVLFATLAAPFWKLAHTLFFWDWSIATSIYCGGVFGYICYDLTHYFLHHQNLPLWWKKLKKLHLEHHFLDYENGFGVTSPFWDIVFGTQLSSQVGSAKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Y0</accession>
    <name>A0ABR3V6Y0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_3678</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000285">
        <property type="protein sequence ID" value="KAL1837533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="172"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="481"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="93"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="304"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1837533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="529" mass="57703" checksum="98BBA438A4BEDAC4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V710</accession>
    <name>A0ABR3V710_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000282">
        <property type="protein sequence ID" value="KAL1837567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="231" mass="25225" checksum="D7E2AF2B0C5F647A" modified="2025-10-08" version="1">MPPSISSAISAFQDDPLVQGVTAFVKEYMSRYDSSHDWHHVERVVAMAHHIYNSSDAAFQATLDLRTIHLAALLHDVGDHKYLPANQPPTSELTTLLTSLSCPSDLALTLETIISAVSYTSETRALSTPTGAAAQASLLAKHPELAVVRDADRLDAMGAVGLARMFAYGAVKGGGRSLAESMEHLDEKLVKLEGMMRTEVGKKEARVRGERLRKFRGWWVEEVGEVGGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7K2</accession>
    <name>A0ABR3V7K2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Initiation-specific alpha-1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000265">
        <property type="protein sequence ID" value="KAL1837762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39347" checksum="CB1A2966527BF17A" modified="2025-10-08" version="1">MLATVQAAVPFVRRPRFSWRLVPLIAASSLLALCLLFFGSPESISWGLQPQQKQSQLPPRPSPPERPGQQQQPDGDHISHQAPITDIPKQIWYKLGPTGLTDTTREWTETCVRRNPDHLVHFMSDPKADDYVKTQFRATHPELVDTFLKLQVPIWKADILRYLLLFAEGGVYLDLDVSCEQPIGEWIPSKYQGKAKLVVGWEFDVGWSENIIRQFATWTIVAAPGLPHVEAALDHIMGNIRKGMKKHNITDPADLEKDMLGDVVDATGPRAFTRGVMKSARELFKVRDQELKKLTEPKLVGDILILPGYAFAASANRYKEAFGENFKVPPPLVTHHYAGTWKNDKGGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V830</accession>
    <name>A0ABR3V830_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000256">
        <property type="protein sequence ID" value="KAL1837877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="259" mass="28807" checksum="34251C2205F6E817" modified="2025-10-08" version="1">MLPKLMPLSPSKLAITLAILPLTISATYLVYLNHRISRECTISASLRNKKKRINTLPPTLPLPTSLPREVASDESEEWILAHERVVLSRPLHPSALPSYDDNLSTVLTHYVRATMTAFSWTPQAFILRASVGDKGVRETFDTAYILSLDFCEGDRVNGFWKIVYRGEVGGHQGSERVELALDAPDGYKGPVVRGLVVAGVEMRDDGEVVFVNETWMWRREGEAPVLLEGRVGGWLHELLSGWLVMKGVRALTEGKGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8A1</accession>
    <name>A0ABR3V8A1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000245">
        <property type="protein sequence ID" value="KAL1838002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="195"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="556" mass="60684" checksum="4FC325904E5D008A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8S8</accession>
    <name>A0ABR3V8S8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1153" mass="126652" checksum="330EE016CCBD0CB6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9A1</accession>
    <name>A0ABR3V9A1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="393" mass="42549" checksum="43A19943877CA1DD" modified="2025-10-08" version="1">MAPRLPARCWRQLSSPSSIAASASLVPRASLLPAPTPITLTTPSTAHISTTSTRSARSGWSTLPPRTAKPYRFNQATSGLPTLTTGPAAALKRKERTTPVRTGVLAVKKGMTVFMGRRGARIPCTVLQLDRVQTVFNKTRSKHGYWAVQVGMGERHPDNVGAPLLGYFEAKGIPPKEILAEFRVRDESGLLPVGVQLMPDWFQVGQRVDVRSNSRGMGFAGGMKRHGFAGQEKSHGNSLNHRTIGSVGPSQGSGSRVLPGKKMPGRMGNQRVTVQNLPVLLVDNDLGIVVVKGCVAGPKGCVVRIQDACKKEPPPKEFVEKARKVLEERFPDAEAHLQAARERHLELKAARREKRIAELMEGGLMVPQEQAEKIEQILAAEAKEGGKNAEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9G0</accession>
    <name>A0ABR3V9G0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_2692</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000216">
        <property type="protein sequence ID" value="KAL1838408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="78"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="317"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1838408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="414" mass="47602" checksum="9176948B42A18AEF" modified="2025-10-08" version="1">MTAEERHEQPANAQSVQDTPGSFRIKRSASEDPESPPDHKRIKVSPDESEKPNVPTVPFIRVPYPEKPAVIEERNGEIEIRVVHNDGERESTILLTGLKCLFQKQLPMMPKDYIARLVYDRSHTSIAIVKQPLHVVAGICYREFRPRGFAEIVFCAVDSAEQIKGYGGHIMNHLKDYIRASSQNLLHFLTYADNGAIGQGFTKEITLPESVWMGYIKDYEGGTLMQCTMLPRIRYLEAGLMLQKQKETVLAKIRRVSKSHIVHAPPAAWKDGIKPIDPFSIEAIRETGWSPDMDALGQAPRHGPYFNELRRLLYQIQGHKQAWPFLLPVNKDEVPDYYTVITSPMDLSTMEEKLEHDQYATPRDFVNDLKLIFSNCRRYNDPSTVYVKCANKLEKFMWSLIKEIPEWYDLLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9K6</accession>
    <name>A0ABR3V9K6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000240">
        <property type="protein sequence ID" value="KAL1838066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
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        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
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            <end position="103"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="306" mass="33435" checksum="5244F5A6B76BB29E" modified="2025-10-08" version="1">MSEYWKSTPKYWCKHCGVYVRDTKLERTNHEATAKHQNAVKRSLRDLHKAADQKEREKERARQEVERLNGVVSGSRGGSATSASTSRSAVRPAGGAYGAAPQQVSEAERQRQLEQLAELGVNIPTELRGNMAMAGEWTVTSTRIIQVPEAGAEDGGDEKGDVSSDARAVGVKRERERTEEEKEQEDAINGLFKRPRKWGIDSKSMPEEEDAELEALLSGPLVKTKKEESEPPKIKSEDAPEGPLQGGAAESDEQGPEPPIKKEPDEETNGDASVAIAGTAKASTDSPADAPAVVFKKRKPKKIRQK</sequence>
</entry>
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    <name>A0ABR3V9T9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="53"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="824" mass="91676" checksum="B78CAC89F8785311" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA62</accession>
    <name>A0ABR3VA62_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1052" mass="115462" checksum="461B1E96496883E6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA87</accession>
    <name>A0ABR3VA87_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_2446</name>
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    <organism evidence="3 4">
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        <name type="common">Soft-rot fungus</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000202">
        <property type="protein sequence ID" value="KAL1838639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="2">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="803" mass="90164" checksum="01B5D84D690F4A21" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAK0</accession>
    <name>A0ABR3VAK0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000195">
        <property type="protein sequence ID" value="KAL1838753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="271"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37474" checksum="DD73F031B952F222" modified="2025-10-08" version="1">MSRYGFSNSWALSPFSSQDGVPHVTEQDYSYITSADLENHGIDIPRPYASQSSYDDPYSQSAPSSGFDHSQPEDDFLHIKHQGVSYPERFPAYSIGDGKLLVSDVRERIKMILNLSDRQAKRLKLYYKGRKLKKNDLPICEYGVKNNSEILMVLDDQSYGGESSAESSLVGYEGRASAATSPRLGRFGGWDDQPHSPRESGSNVGLEVPPDNNRRRAHSMVRTQSPSGSAVSAASAPPAPPPVGIPGGPIERLNAIAAEFHTKYLPLCAEYIARPPQDEKKRVEEHRKLSETVMQHVLLKLDGVVDVASERGAKARRKELIVEVQGVLNQLDEAKKGKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAN4</accession>
    <name>A0ABR3VAN4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000194">
        <property type="protein sequence ID" value="KAL1838776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264:SF1">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="368" mass="38963" checksum="B80E8CE922CE5759" modified="2025-10-08" version="1">MTNLIVDTDIYSDVDDAAALLLATTLPDANLLAVNVNYTSSYSALAVSAILGHYNKGHVPIGIRRPLTDDTFFDIKHFSLGEFASKVAFHFRDSGGSLPWGRAEEAWDPVQLYRKTLAEAEDGSVTVVSIGFLDNLSALLSSPPDTHSPLPGAALISLKVSHLVVMGGAYPTSTNPDTGTSHPSWNFSGPNGSHAPAAAHVVSHWPGRVTFLGREVGANVIVGGPLMGAAPGSGVPRRDPVRMAYLWYTYGGLFDEDGDRRKRGGPAWDPLAVLYAVREVGCGLFEDVAGEGRRGWCVVDEKDGGNRWVWEDEGGGGDDHEGEGRREHAFLSLKVSPEGAAEVVDELLLKGARSGGRGSFAGGGKGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAT0</accession>
    <name>A0ABR3VAT0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000184">
        <property type="protein sequence ID" value="KAL1838944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="200" mass="22927" checksum="AF805ABA634FB9E8" modified="2025-10-08" version="1">MLSTEPARCVGFRDSYLFFTKHKKLYKIIVNDEEKRDMIERDIIPHSYKGRSIGIVTARSVFREFGALIIVGGRRIIDDYEVAKARADGVVEGELADPNDIYDPDKPYNKNQYVAWHGASSVYHSGGPSAPQQNVKVDTKKRRVAVNDVNWQLEHAREASQFNSILSAVRRNNLNGVYDIHTNQMHYPRIMQPTHARIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAY4</accession>
    <name>A0ABR3VAY4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GET complex subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000193">
        <property type="protein sequence ID" value="KAL1838795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="38227" checksum="AD4B70A1C771CA07" modified="2025-10-08" version="1">MGELTPEEEAAAAAREEEARRLRKARREAKIKAGAGDRLSKITGLASGVPKNPSLARSATMPASNPIASEQQPLARSSTIPVAPVASSDQQAKQHPDPAEVDISEHFYKPKTTPRPSASPAGPEGEGPVLDDAQLRRMMLGLDAPTRASTFNSPGLTPPAGAGAGAGALPEGNDPMMKLMMQMLGSSGGGGSNTNNPFAALMQQPPTQPGQKQQQLQQQPSKAASLWRILHTLIALSLGLYIVLATPFTGTKLSRDRAAAAEAGSAEERALLGEEVNAVREKFFWAFATAEAVLLGTRWFVDRGSRVQASGAAGGLVGLLVGFLPPAVKSRVELGMRYAEVVGRVRGDVLVCVFVLGVGAWWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB30</accession>
    <name>A0ABR3VB30_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000205">
        <property type="protein sequence ID" value="KAL1838591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="2">
        <location>
            <begin position="175"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33956" checksum="4B016619F8B3520F" modified="2025-10-08" version="1">MSTPGVGFEYPRKEVSWTQRDALLFANSIGATSKELHFLYELHPNFAVFPTYPIILTFKGTNQEVTDFYAEQKAIPIPGVPEFDPTRVVDGQRLLQVFKPLPVTSAGRKFEVRTKVIGVWDKGRPGSVVDTQTDLVDAATGEVYTRVISSSFYVAQGNWGGPKGPATPSYPPPRDRAPDATWETQTSAETALLYRLNGDYNPLHADPEPGKKMGFGGVIIHGLYSWNWTAHGLLEKLGGSNPANLKEYQARFASPVRPGDKLVASAWRTGKKEGEWEEVRFEVKNGDKVCLSNGRALMKVEVAGKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBL5</accession>
    <name>A0ABR3VBL5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000207">
        <property type="protein sequence ID" value="KAL1838563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="304"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="474"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="672" mass="73777" checksum="97D7FB5DA1CCD84C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBR9</accession>
    <name>A0ABR3VBR9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000176">
        <property type="protein sequence ID" value="KAL1839080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="256"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="422" mass="47404" checksum="07F472400D346515" modified="2025-10-08" version="1">MANLINVRRDIKDHFYRYKMERLQTKIEGKGNGIKTVVVNLSSVAQSLARPGNYLIKYFGFELGAQTNLDPPDDRWIINGAHEAGKLQELLDGFITKFVLCKKCKNPETDVHIKDGNIMLDCKACGQRSEVDPRLKLSGFMLKTVPKKTKKDKAERRAARKAKQNGKNEDNSGSDAGGNDQSSPTEDKGVESDDDALTRKIKSEAQVLEKKAVEVRDDDWAVDMSEEAVRARAQQLPGEFKQKLVLNGDEEDEDGEGGGNTVYDKLGTWIMEEAEAKGGVDKVDDVDIYVKAKELGIETKHRTVLVLAQTIFDENIVSQIKSRAPMLKRMITSERHEKAFLGGTERLLAQLLEQDKDALTKVTPILMAYYDKELVSEEVITKWGTKASKKYVDLATSKKIRKAAEKFITWLQEAEEESDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBT1</accession>
    <name>A0ABR3VBT1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000175">
        <property type="protein sequence ID" value="KAL1839095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="117"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="268" mass="29922" checksum="24C1A5A2DBB49068" modified="2025-10-08" version="1">MAPNPSRTAISATSQALRRCACSAQTMAPRRLVQATRKLSSSSTTRSPETPESASEQQQQERPRWSYTPERMKGPGFSINIVKKPSRTIWHNNEDPAKLDAMYNRLLGSKGPDMLPDEIKWLAVTHKSFDQGRRGFNTRLAYFGRLILSLETTRHIMINPAPARDSPSPDEFGREPFQHPALANVDKLQTRQPQDIVSKEKLTKLAIDVGLPEVVRWKPKMPENLEGSGLAVILNTSLFAIIGAISLQHGAEVAQKIVREKILRRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC06</accession>
    <name>A0ABR3VC06_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000160">
        <property type="protein sequence ID" value="KAL1839385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="237"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="618" mass="65732" checksum="09C9C0FD1F7E9681" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCT5</accession>
    <name>A0ABR3VCT5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="786" mass="89877" checksum="0CEDC7F706871604" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD52</accession>
    <name>A0ABR3VD52_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000143">
        <property type="protein sequence ID" value="KAL1839727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="202" mass="21386" checksum="04F44F2DF343C6C1" modified="2025-10-08" version="1">MASNLPTENAEQANAPAKVPNGVSSTNDATDTNAIAPEPSIPEPRLPTRKDASLKEFLNKMDDYAPIIPDAVTNYYMTRAGLPPPPQTDQRLARLLALATQKFIADIAADAYQYSRIRASNTNANNPMGNLGAAAGFPIPGQPANQPGAKDQGRGAPLGIQRPGYGGGGQGSSQNRTVLTMEDLGMAVGEYGVNVKRSEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDA5</accession>
    <name>A0ABR3VDA5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000139">
        <property type="protein sequence ID" value="KAL1839810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344:SF27">
        <property type="entry name" value="KELCH REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344">
        <property type="entry name" value="OS02G0202900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046224391" description="Galactose oxidase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="40092" checksum="976C724CB39528AF" modified="2025-10-08" version="1">MRWNLTLSAAALQGAVLVNAIPGREGGHWKELASIPLFPRQEHTALSLNTTHLAILGGIIPGSSPSNPFPTTPLIQLYSIPTNTWVSLPDLPLPLNHPNAAAVDGKIYLLGGLNDEAGDGVWRGDGRSWVFDFASLAWSELPAMEEANGDVPRGSAAVGVDPDTGIIYLAGGMTRLPVVEGQGNQESVDHVSAFDTRQGRWVTREEFARGRSEAEVAQIRTMPGRRDHAAVAVVDGVLYVLGGRVDGQENVRGEVFALDLKGLLESKSGKGKGNGKKVQGWVTKRARMPTPRGGVCGAAVGGKVYVFGGEGNPEEGSEGVFDQVEVYDTRRDRWESVGRMRAPRHGTAAVAVGGGIYIPGGGVRLGGAPVDTFDVFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDT9</accession>
    <name>A0ABR3VDT9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="415" mass="45196" checksum="5FDA45D5AD7EDDA6" modified="2025-10-08" version="1">MPRDPLIGLVGKPSAGKSSTLNSLTDASSKVGNFPFTTIDPQRAIGYLQIDCACSRFGLTDRCKPNYGACVNGRRSVPIELLDVAGLVPGAHQGKGLGNKFLDDLRHADALIHVVDVSGTTDAEGKNTRGYDPSVDIAWLRSEIVQWIKGNLMEKWGSIKRRHVAVKATAVETLQNQFSGYGSTAAVVARTLDKLGLKEPLEEWDEETIDRVVNAFTDEKFPTVIALNKIDHPDADKNIAKIAKMQDPNKIVLCSAISEIFLRKMAKQGYIRYIEGSEYIETREDLIADGDPTGGGLKELDDKNRNRIENLKDMVLYRFGSTGVVQVLSKAAEMLGLVPVFPVRNITTFSSGGSSKEVFRDCVLVKKNSTVADVARKILGDAPIAYVEGVGGIRVSEDQIVSVGKNDILSFKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE00</accession>
    <name>A0ABR3VE00_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000135">
        <property type="protein sequence ID" value="KAL1839923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="467" mass="51356" checksum="EDAEFAD6A7FA82FC" modified="2025-10-08" version="1">MSVEVITTISPTTNEPILTRNGISAEEIKQLPEIAAQSFTTWRKTTLQERKDIVRKALAILDQKKDELANELTVQMGRPIAYTPKEISTAIKRAEYLLKVSDEVLQDTPGEAEAGFKRFIRKVPVGPVLIIFAWNYPYLILVNALIPALLSGNSVILKPSPQTPTIVEQVAKAFAEAGLPHGVIQYFHSGSPTVIDSIVRDPRIALVCFTGSVAGGLSIQRAASDRIVNVGLELGGKDPAYVRGDVDIAWAAEEIVDGAVFNSGQSCCSIERVYVDEKIHDDFVAAVQKVLKGYRLGDPLDKDTHLGPVISKRSKETIEVHIRDALDKGAVNATPENETFTKLPDKGNFVPPTLLINANHDMKVMKDETFGPVIPVMKVSGDEEAVRLMNDSEFGLTASIWTKDTARGYELAEEVEAGTVFVNRCDYPSPDLAWTGWKDSGKGVTLSRYGFDQFVKLKSYHLKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE14</accession>
    <name>A0ABR3VE14_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000161">
        <property type="protein sequence ID" value="KAL1839371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="450" mass="49605" checksum="79F3FE00A919C3F8" modified="2025-10-08" version="1">MCGASLFFILWNLIWDLLFVLGCVGWRTANFMVHNVNVTHLAERLHEYALVDTGTDVTPIVIPELPEFWNFGISGICDNFTATREVYCRPTFAPTHHVLAVLEESLRDSLRRHAAKEKGENENGANDKTPEDPDPELIKTVISSWNETLAGLSPSGLVAYEDKVDALWRAGAILGVGAVVADMAGVVSICAGPLKVPMLIITYPIGGLIALASASCVEDARRMSMNGPYGTNEGGLDATVGLIFGNSGLRLVIGIGMACYGWATRRAKRREKSATRNPPPVPPVTTTMTTTLTHFPTVEMNVFNNTGTTEAPPPYTAIGANQPSVEPVPESEDDSEAEEPRKEEVAYLGQRFVYDWLDRCELLNWSFDNWMSPLRSRAGFAAYRPELGRDHADFSYNDVGGQMDSVLRRVGLNPPEAKTYHFKVQATYGPCDERKMRLTEDQIRLVTFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE37</accession>
    <name>A0ABR3VE37_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000128">
        <property type="protein sequence ID" value="KAL1840072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="66" mass="6069" checksum="795D9AC4998E8C12" modified="2025-10-08" version="1">MSSSGDSSSSKWDEILSHGSALGILKPDIAFPPTGGSSGSGGSSGGSSGSTGSGSSSGSNSDGTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE52</accession>
    <name>A0ABR3VE52_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="84"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="181" mass="20193" checksum="FB7B82A3186C57E8" modified="2025-10-08" version="1">MSDSNTPDKTERHAQMFLSLKGEDRIRVVLEDFGKQVADPDEKEWTQLLIPYMKIESVSPPDAPHPSVTFRFTVQPEHCNRLRNLHGGCTATLFDFCTSVPLALVARPGYWSRLGVSRTLNTTYLRPAPQGTEVLVECDIVQIGRRLCTLRGIMRRASDGIILATCEHGKVNTDLDVGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEE5</accession>
    <name>A0ABR3VEE5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7143 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055567">
        <property type="entry name" value="DUF7143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37592">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37592:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23631">
        <property type="entry name" value="DUF7143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047483387" description="DUF7143 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7143" evidence="2">
        <location>
            <begin position="31"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="192" mass="21107" checksum="CBE1BBE9A6754268" modified="2025-10-08" version="1">MKFTTVIALFAGLVASAPIDLEARQSRACFVIGTQTLPQETATIAEQLRGRIRCDASRRTLSGVPDVSSGNVRFSAINFATDPRRRTSLQFALEEFRTATPLRNTNLADFQRKLDVYLATEAGIRSVGGNLAIKVPKFFLQFQVSRIQTAQGNPPTAPGLQVDHLLEKVLKNAPRESQALRDEVVRLSKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEM2</accession>
    <name>A0ABR3VEM2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-dependent rRNA helicase rrp3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_662</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="100"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="295"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="456"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1840284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54349" checksum="8EAA2F081BBC78A0" modified="2025-10-08" version="1">MLAKRRKITHANGEAKKSSVPAAKTESKTESKSQSKPEPKQASPPPSSVEESATLDNSSGQGNGDTVQKTFRDLGIVDSLCDACDRLGYKRPTPIQAEAIPLALQNRDIIGIAETGSGKTAAFALPILQALLDKPQPLFALVLAPTRELAAQIAQAFEALGSLISLRCALILGGLDMVQQAIALGKKPHVVVATPGRLLDHLEKTKGFSLRNLKYLVMDEADRLLDMDFGPILEKILKFLPRERRTFLFSATMSSKVESLQRASLRDPLKVSISSSKYQTVATLVQNYIFIPHMHKDTYLIYLCNEFAGRTIIIFTRTVLETQRIAILLRTLGMGAIPLHGGLSQSARLGALNKFRAGSRDILVATDVAARGLDIPNVDCVLNFDLPGDSKTYVHRVGRTARAGKSGHAISFVTQYDLEIWLRIEAALGTKLSEYALEKDEVMVFRPRVEEAQRHAKNEMKQLLEDRGKKGSVLKGGKGRKRAAPGSSRDDMDAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF39</accession>
    <name>A0ABR3VF39_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000116">
        <property type="protein sequence ID" value="KAL1840366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="433" mass="46040" checksum="1197D653EFCBA24A" modified="2025-10-08" version="1">MVRNLVLLSGSSHPTFADKIGEALGVPPAARVLTHFSSGETRCEIRDSVRGKDVYIVQSFGVGGISDGKRKTVDDYFIELCIMISACKTGSAARVTAVLPLFPYSRQPDLPFSMVGAPHGSASASTLSAALPPTLKGDGGAGAQQTTAATMAMDEPSLERAGAQRPESVARYTTHDYENPALMMTLQQKARSGHKHLTAQAGPLVADLLTCAGADRVLTCDLHEAAYQGFFDIPVDNLYARPLLQRYIRHHIPNYRDAVIVSPDAGGAKRATAIADRLGLAIALIHKERRPPDISHPQRATMMLVGDVAGRLCILIDDLADTARTLTRAARLLRRAGAARVVALLTHGVLSGDAPARLAAALSSSGPGTGTPVSAVAGPVLDRVVVTNTVPQEEHAAVCGPRFEVLDVSGLFAEAIRRVHYGESLMRLFEYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF71</accession>
    <name>A0ABR3VF71_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000110">
        <property type="protein sequence ID" value="KAL1840494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="102" mass="11624" checksum="FC0D31ED05C7859A" modified="2025-10-08" version="1">MVSACYRDVVVDFEGLNWWEQAYGPHLSLMYGDQPVPEETLEEVAKVVREAGVKLADDDEQATEQDGQGEQLWDGWEGGEIWLVPTYKPISEWSKPIARIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFB6</accession>
    <name>A0ABR3VFB6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000108">
        <property type="protein sequence ID" value="KAL1840563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="389" mass="42554" checksum="948812891C2A0614" modified="2025-10-08" version="1">MAAVGPSSSSGEKAQLQWQQLPQPSPSQPPASGSNTVPMTEEELDYTSPVPGSSYIAARSPTPPPYSGPSTPAQQVPSPMPQDHDPSCIPRYPGLPVINYRLYRPPLFDLSADKTTIKTTAAHFSSNAAALVALIRQQATVPPKPQIRIVGRRQHNPGVDFDLRLNLLPLLVPDDPKQRMDYLRCVGPGELAYRGGTKPSIKPDLEDGGGGGGRRGSSGGSGLEAWAARYVADSASVKAFVLERVLVNLDADWIEGQIRKLIVSMRYPGSVSVTFPTTHTRVVVQNPDKVNKFLTSVAGFFAGKRRYEVVKAVWPFATMPRGSDPGDEGRRCAVQSEETWWREWREPIRYAIASKRVGWVTNEDKLEIIMEGWAGEVDWSGQPIQQNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFI8</accession>
    <name>A0ABR3VFI8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="55600" checksum="2DB21C645AB649CA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFW5</accession>
    <name>A0ABR3VFW5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000123">
        <property type="protein sequence ID" value="KAL1840183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1105"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="965"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="975"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1206" mass="133903" checksum="5A7FC0FCC0260AB1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFX7</accession>
    <name>A0ABR3VFX7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="154" mass="17680" checksum="86B59CB0B29949C8" modified="2025-10-08" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKVYTTPKKIKHKRKKVKLAVLKYYKVDGDGKIERLRRECPNETCGAGVFMAAMQDRQYCGRCHLTYVFEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG00</accession>
    <name>A0ABR3VG00_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cystinosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30962" checksum="69ADADC117EF139B" modified="2025-10-08" version="1">MGLLEILSSLFGVGYFFAWSLSFYPQSIHNFKRKSTSGTTVDFPLINTLGFAAYFIYNSALYYSPLIRAQYAARYKGLTPTVQFNDIAFAAHALVLSAITTSQYLLASTWGFAPSLGNKPSRFILGIFFGCVAGVAIVVLTVLSSPDRDSTESVSSWVWLDALYALSYVKLIITLIKYTPQVIVNYRNRSTRGWSIWQILLDVLGGVLSLAQQSIDSYLQHDWSGITGNPVKFALGNVSMVYDSIFMIQHYVLYRGASGTQRERDSLLAEDEERRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGF5</accession>
    <name>A0ABR3VGF5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="385" mass="43302" checksum="CAF9B5D8F2BBA2D9" modified="2025-10-08" version="1">MPLPYEVVLLAAEHLDTVSIRSLARTCRIVHQLVQDYEHSIAKGMISRALPEPINLVSPISILSTTPIAISSMTRDSAWENLWNFRSAILSGPTFRLVAELEARGRRIDAFLAPRTPDSPRGVGILRDCLDKLDQFRGLREHETAGLIQGLKEACRLVDHLADLGALVHANPTTKSSTIPGADGSLRTLHPKVALAPEIHNARRRFLIEGGLTPLQLAFLSLLADLYSRVPLPMEHPTFQDTPEELSKRRESFLRHGTALLYAQAHIPEFDLPATMTPVARMKAHTAYRQLQAYYRKEDGWVFWELRNPSPDNLQQTLLDAVKGSEEGEDKPEETDDEREEEDVWFDAGEDWSEVGEDGQGEEQGKLKEQKSVRDAMILEWIARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGJ0</accession>
    <name>A0ABR3VGJ0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="239" mass="27551" checksum="CB7976E2CBAEAC48" modified="2025-10-08" version="1">MADQGLDRNDVTRAEAERDIEKGEGPSNEVENSVTPDNDARRGDDGGADDSDSDAVLSIHDEMDYEERVFRYTFNLRRRDPQPMFLIFRSLQQLNLVRLQNDLARIKTHVWQEKRLREEDSARLTTLLHDYTTVIRDYNYLRTLVPITGSQAQNNRTALEQAFGLEVGDFTDDGGGYGRFPDPNRPPSDNLRDFLKRHLPRSVTYTRADKLRRFEEYLRGLPAEDVSPLSTALLAFSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGU6</accession>
    <name>A0ABR3VGU6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24119" checksum="6FDA28ACE7A3EF58" modified="2025-10-08" version="1">MRDMEVAGKSAQAHPTRSSRLHHITRPLTIASWTLRLPANCHVPPRCPLYLPFGDARLINSNHDKPHPSHISFPLLIQHNPQNANMTRSHKFNDKDHAGLAEGTAVPHEPVPKYFGKNGFPDADPNKTKKNGAGRANWGTFDDDLLDENFNYFNARRRSNSSTHSAHIENFKTKFEINEPEPVFEESMGPEEEERTESSSTATSTDENKSRKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH11</accession>
    <name>A0ABR3VH11_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate repressor protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000107">
        <property type="protein sequence ID" value="KAL1840588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF17">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="5">
        <location>
            <begin position="477"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="4">
        <location>
            <begin position="613"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="92430" checksum="62BC154467C6746A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH14</accession>
    <name>A0ABR3VH14_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF10">
        <property type="entry name" value="GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044956126" description="Glucanase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="444" mass="47267" checksum="53AED79C2E281F82" modified="2025-10-08" version="1">MRASFTVLAALLAAAGSASPVPELEARQSGNPFVGRTLLVNPGYSLKLDQTRQAFLSRGDQANANKVKYVQEKVGTFWWISNIFLLRDIDAAIQEARAAKQRGENPIVGLVLYNLPDRDCSAGESSGELKLSQNGLNRYKQEYVNPFAQKLKAATDVQFAVVIEPDALGNMVTGTTAFCRNARGPQQEAIGYAISQLQASHIHLYLDVANGGWLGWPDNLGPTAEEVRTILQKAGSNARIRGFSSNVSNYNPYQTDNPPPFTAGSPSADESRYANSLGEAMRQRGLPSQFIIDQGRVALPGARSEWGQWCNVSPAGFGQPFTTNTNNPNVDAIVWVKPGGESDGQCGMSGAPQAGAWFDAYAQMLAQNAHQEIVNGANNNGGGNQPGTPTQPTQPTPTSNPGGGNGGGNCASLWGQCGGQGWSGPTCCSQGTCNAINQWYHQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHL1</accession>
    <name>A0ABR3VHL1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000085">
        <property type="protein sequence ID" value="KAL1841153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024014">
        <property type="entry name" value="DMSO2_SphG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04021">
        <property type="entry name" value="LLM_DMSO2_sfnG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="5">
        <location>
            <begin position="40"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="397" mass="44800" checksum="1F9781FC2EFF8C10" modified="2025-10-08" version="1">MATVEPHELNRDPNRLLFAYWVPNVSGGLVISKIPQRTSWDLDSNLRYAQTAENVGFEYALTQIRFTASYGAANQHESVSFSQALLHGTKRLRVIAAILPGPWSPVTVAKQIASIDHYSKGRIAVNIVSGWFKGEFTAIGEWWLDHAERYRRSNEFMRCLRGIWTSGQDKPEEEDPGFTFAGDFYRFRNYRLSPKPVQKPHPPIFQGGNSDDARKNGAEVADWYFMNGNDLEGFRAQIEDVKARATKVGRENQVKFAVNGFVIVRDTEEEAVRVLQEIQGKADAEAVEAFAAEVKNAGQSTANKQGMWATSTFNDLVQYNDGFKTRLIGTAEQVAERILLLKSLGVNLVLTAFLHYEEEVERFGREVLPLVRKLEAEGRGKDADFEIARTGDVYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHN6</accession>
    <name>A0ABR3VHN6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7468</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="119"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="228"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="342"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47477" checksum="4D72160677DF515B" modified="2025-10-08" version="1">MPAELSASHDDSQRPRLLQDGPARARGLPLPIMPSSTTESNQREGQQEQQTPSHPQSRNPGRPALNQRRTAEVESEDEFCPDPRLAAGAATAAALRRSSEASVGPPVADNAVTSYQRLVKRYRTEVAASASSVLSTLTTFPLDSVKTRMQTYRYAGFIDCVRQTYRTEKLRGFFRGVTAPMASITLVRTVSFSIYQRSKYVYCDWIKRHFGVDVMAHVTSPGTYPNAWSIATFGAAGATAGSCITVIACPFELTKLSAQVSVLLADKKNCPKPESHAIAASYQNKGTLKTLRNIIKHRGFGGLYTGFRLHLMRDTLGTATYFMTYESSKQLLTTFGGDGTHSNPLAVLVAGGLCGIVSWALIYPVDSAKSIYQRNSLLYTKGEKVEPVKIRFFQRNMYRGLGVSMGRSCAVNAVFFSSFEFLKKRIKAMDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHU6</accession>
    <name>A0ABR3VHU6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">VTJ49DRAFT_7390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="166"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="435"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="761"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="786" mass="88911" checksum="BEC612AFEA3CFB6E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHZ2</accession>
    <name>A0ABR3VHZ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7122</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="667"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="842" mass="91026" checksum="91408071A6ABE256" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI62</accession>
    <name>A0ABR3VI62_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA repair protein rad5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_6941</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="497"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="891"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="981"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1841568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128726" checksum="4D2CD99F44E99EC8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIG6</accession>
    <name>A0ABR3VIG6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046302956" description="Ubiquitin-like domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="265"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="500" mass="56806" checksum="668203FF21644E21" modified="2025-10-08" version="1">MEAALTFGSLGDILALGQLIIQLVEAIGVGSRDAGGSAREYKDLQRELSEFGRVLLQVVATYEQCGHSVYLNELDNATRAVVDECAGLIAGALEHFGGRYHVSLQPGGSESWLRDARKKVSWFLRERERVNELREKLNRNIQRLTLLNGLAIRKSARVDNATMRARIDEVHHLVSAHVDNYQDLIRLLREQRCTLKNQADQLRTANTQLAAQSGTLSDILAGVKQSLAAAREIKHSLAEVAAFVANFQVYVSSTMSLYALNPTKELPVTIEDPLGRHLTIPPELTDCLQWSTFQSILEDRFRGFKGYDRVSMRLYTLEEACTGRDIDRLKPLVCSLRRGMRVNMSMVFENPSRENRYACPRCGATVSDAKEKTRQCTTEGCGMQLQVCSRDTVDFLNTWDIDVNNKTAAVNSQAHNSTPTDFVRVRFHVFDLYGHHNLDDYQMVLEWWEKSRIMTALQDYPSKTSPLDYQMQLVLLEGQNRKRLMMLREEQDRGYQHATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIS8</accession>
    <name>A0ABR3VIS8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19984" checksum="0C759197D0FDB07C" modified="2025-10-08" version="1">MAQVRREGLSLISNGITKRPDGSEVPPVVDIIFVHGLNGHPENTWRGETGRPSGEKAKRSCNIMKFWSKKRETVSQKVFWPHVFLREDIKNARIFTYGYNANVAEGFLKGSNQNNIYNHGRDLAAKFQRELGEDNHYPIIFVVHSLGGIIVKDAIHQSRFLRERTKLVVFFGTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK17</accession>
    <name>A0ABR3VK17_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF1640-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6073</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26381" checksum="EAE6846BECC57528" modified="2025-10-08" version="1">MADDAEEKRSHGDSGGRDDETEDDNTYKTVFSTIARNPTLRRSFHASPARRRDHHFDTLRFVQRLQEEGFTEEQSVAMMRVLNDVIEESIQNLTRTMVPREEAAKTTYTQKVDFAKLRSELLSADSTESSATRAAHERLANDIAKLSGRLRDEISRTQASVRLDLNLEKGRIREEAVSQELKIKETETKIEQEAAALRQQLEQVKFQTLQWLIGVCTGFAALLLGAWRLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKL2</accession>
    <name>A0ABR3VKL2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26829" checksum="3C467C5D956DA77A" modified="2025-10-08" version="1">MTTTNPNPNSITIRLPSQYPNGDSTTQPTTFTPPPLPFLYRTWTVTHSTLRMWRSARNVRITYGELPPKEVKAGDTKQQQQGQQEQQAQARMSDLVESEFLSGKGGVRRIEGIDTATSPSDTSSWDWRGKPLWLRLLAGTSHWEVLGWGERVVVSAQDGGGEEEGQQQVERWMVTWFAPTLFTAEGIDIYSDRREGGSEGLVEDVLAELKRVTKGRGKLGELVEGEMRKVEVVLPWKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKN4</accession>
    <name>A0ABR3VKN4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="276" mass="30313" checksum="2FAEBAE0F096AC22" modified="2025-10-08" version="1">MAARGLNFIYAAAVPTAVGIGLLQSAMYDVKGGTRAVIFDRLSGVKETVVNEGTHFLVPWLQKAIIFDVRTKPRIIGTTTGSKDLQMVSLTLRVLHRPDVQSLPKIYQSLGPDYDERVLPSIGNEVLKAIVAQFDAAELITQREAVSQRIRQDLMKRAREFHIALEDVSITHMTFGKEFTKAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAESAETISRAIAKAGDGLIQIRKIEASREIAQTLAANPNVAYIPGGGKGTNLLLNAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKU1</accession>
    <name>A0ABR3VKU1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000040">
        <property type="protein sequence ID" value="KAL1842520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="60334" checksum="F0BE13AF10601AA2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLN4</accession>
    <name>A0ABR3VLN4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="779" mass="87560" checksum="7D1B4974A4948304" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLU5</accession>
    <name>A0ABR3VLU5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="285" mass="29959" checksum="AFAA08C198AB0BF1" modified="2025-10-08" version="1">MSMPPLYKPSPVRSSPFMRPKSPASVAPLRQTTPSSSPTKHTSSPVPPLHGFSTPRGRVTVEDAPESTTSSPPRITPTTTTHSFPLRPTPRPVSSSGGGVAAHGNALSKLQPSQVRAMREAFQILDRDSDGVVNREDVADMLNQLGLPSTPADIAQFFSPSSPSTVTMAMFLNSIASSLVELSPSAELLSAFSAFDDDDSGQIDVAELRDALLHTAPEPGQDKLTALDVEKVIAGFTGRRAFSKSNTGLGSAAKRGEVFRYQEFVNTINGANGTGEKAGEGAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM73</accession>
    <name>A0ABR3VM73_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="327" mass="35256" checksum="B03AAA9CA5AF9223" modified="2025-10-08" version="1">MNGNIFFTFGPTPGSYILDTPRRFCTSGLPYAMKRGLTNVRKVHWAVFGDNGNAAFMYTGTAHEEGLWRWHSDAFKSRLPKAHGFIEKKSQEGGAANISVTLGKGESIVICAPDRNQVHGCVDESIKERIMAYDRIRHVALGVGDAYVIFHSKGIAYNLRGNYDKLDRILDSLSAQDISYAALNPWRAEEFVLVLADGTVRFSVHESIKDDLMSALRDSNGSQTARPRRQAAMPRSGGQGLHNQIMVNAVGGAAGGVASGIVQTGLAGFTPIATAQPDVYEFDGAAEPDVAGFDDTAEPDVSGFTDVLQPDFSGFIDPITTSGCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMM0</accession>
    <name>A0ABR3VMM0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_4576</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="112"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="474" mass="50699" checksum="D91D59EF72B3A3A6" modified="2025-10-08" version="1">MAPSPLPDYVYKILPEAPPDPIPTPFPLSDLDKNDGFVHLSTSWQIPITASLYFASHQKLYILKLRLANFDPASVRWDEGGPGSTPNGCPHLYGNFGKEDVTIVCKAAIAWGAGQPLSYEDVEVAPPKAHEVRIKIHYTGVCHTDAYTLSGKDPEGAFPVILGHEGAGIVESVGEGVTNVKPGDHVVALYTPECRECKFCKSGKTNLCGKIRATQGRGVMPDGTTRFRARGQDILHFMGTSTFSQYTVVADISVVAVQQDAPMDRTCLLGCGITTGYGAARITAKVEKGSNVAIFGAGCVGLSVVQGAVAQGAGKIIVVDVNPAKEEWSRKFGATDFVNPTKLPEGKSVVDTLIEMTDGGCDYTFDCTGNVSVMRAALESCHKGWGESIIIGVAAAGQEIATRPFQLVTGRVWKGSAFGGVKGRTQLPGLVTDYLEGRLKVDEFITHRKTLAEINDAFEVMKSGDCIRAVLDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMT5</accession>
    <name>A0ABR3VMT5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="126"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="488" mass="51919" checksum="DA7761081DBCBA4D" modified="2025-10-08" version="1">MLDEHRLTPASISKLEVHGAPNTRRALLDHVLKPLVDDSAAPGTTLGQVLDRIGEATRKLSRFDIFKEEGFNVFLSEAPRPEGAPADRTDLEVAINVKEKSRLVFTAGTDFGNAEGSAYTNAVARNIFGGAETLSINASTGTRTRSAYNATFSTPINGNPDLRLSVEALRSATQKPWASHEERLTGGNLRLAWLTENRDTHILSYSSVWRQLTGLSTTASPTVRADAGDSLKSALTHTFVRDRRDNPMLPQRGYLFRAVSELAGWGPLQGDVSFTKAELEAQGNLPLPLNGASLGAGFRFGLLYPLPTGYSLTGTAQPSRINDRFQLGGPTDVRGFKLGGLGPHDGADSVGGDVFAAGSISALLPLPRTGPESPLRLQFFANAGRLVALSTKTKSKSKGKEGKEGREGLAMDSATVFKSVKSAVGELGNGLPSLAAGVGLVYAHPAARFELNFSLPLVLRRGEEGRKGLQLIPSYHSVSGISSSQHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMT6</accession>
    <name>A0ABR3VMT6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046027877" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="318" mass="34961" checksum="577FD273FDFBD731" modified="2025-10-08" version="1">MLLYPAAIAALLAALPGAAASKRGLVFTPNSTTRSDDKIWVQKPTTLTWYYNYKPEPEATYEHLPQSEFEFVPMMWGAPSTIDDTSFVTTIKNLIKKGINITNVLSFNEPDGPFVYGGSNMEPSVAAQVWVNNMIPLQELGIRVGLPACTGAPDGLPWLQTFLQECSKLISTSDKQRNCTYDFVTIHWYGSFEGLASHMGQYSAAFPNKTMWITEYNLNNQDLESTQAFFNMSAEYFDRLDFVERYSLFGAFRSDVSNVGPNGAMLSVNGSLTDIGAWYLGREATGILPSATSWAFRSVTPRASGVVLGALFAAAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN50</accession>
    <name>A0ABR3VN50_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52903" checksum="D55B9E3F6D57C6C3" modified="2025-10-08" version="1">MPVQATPLNFLTSMLPSSRPFESKIVHLELANNAVIPIHHAVLLRYNPTVSRLITKNDTTSGSGDRMALNLTKFPRPAGHTVVNFLYTGSYEVLYPIDDADSGAIKVTDMKLRFEIYALSRILGLGRVSDNASVDIKMMAAEADDPNFVVDAIRAAYPGDRDKSFEDKINRFREDARRPSARLGYSSLLDIALRRMIDAYAEAMTKLSFTATAGALADTELLADHFSVTVASSKEPTESMMDGDRTESNFEPSPYNDKIVHLKFADDAILTAYHAILVRNEDIAQLITMEEFKIVSDLDSDGNTPVCYDRMIIDFTPFSPPADHALVDYIYRGSYGFPNKINTGTNPQPDQMADLVLRLEAYALARRARVYGLARDIEDAIERVTVFELGVMVLRDAILAAFSKFHGKDPELEKKLEELAVEFKLTGRYSTPGMTSSRWPMVRQDMLMIANGRLEEMMRAYADAVERLVAPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNE1</accession>
    <name>A0ABR3VNE1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="212" mass="23225" checksum="83D129E36DAC2623" modified="2025-10-08" version="1">MVTYGVTLLRTPISTGAAPIGSGKSRPGCGVVVCQKKSSTALEAGPIFAIHQRRLHRTTPIANDTISLLSTTRQRDQFHGHTTSRQTGFPTQTTFSPSSSRSETSAVHHGLSARYRHRCRRRRLPRTSPNHTPRLCSLSPSAHAQPTTMTEKDEMKEKLGLTRPSINQQGRAGLVAWRRSRGGVGALGKAFYKGGFEPRMTKREAALILSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNH1</accession>
    <name>A0ABR3VNH1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59206" checksum="693EF09297BECE30" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNW8</accession>
    <name>A0ABR3VNW8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="354"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="619"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="694" mass="76309" checksum="022C97A3E679DD7B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP92</accession>
    <name>A0ABR3VP92_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="156" mass="17207" checksum="C4A813E94B9C1228" modified="2025-10-08" version="1">MRILLSLALHSFKHCNYAKLMRYCVIYLDQLMKFDLQRHGPEKTNAGQAGRKISSLPSASVALDSRRKPSSLLLPTIIKTLSPVFVVSTASEHSLAVAADGKVYIWGLNLTKQIGQKDEEFEVPTLLAHEEVADKRFVWVGAGAQFSMFGEAVDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPA9</accession>
    <name>A0ABR3VPA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="199" mass="20470" checksum="F97B41C4A06491E3" modified="2025-10-08" version="1">MTEATPANASSGDTAASSAAGIPYYEKQRHHLKELIFKRKQMEKKLANIEELILAKETEYLESTPSGNIITGFDNYIKGGTAAAAAQRRKASMTDQNRVFSRSSVSYNPAAAAADAQTPASTPASHAPTPVSTSFGGDPKARDGPSGAPTPNSTATAAGGGGRGGGASKKGKKHAAGAEDSETDGREAKKARTSFGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPB2</accession>
    <name>A0ABR3VPB2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1843003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="334" mass="35363" checksum="CF99AC2578801F5D" modified="2025-10-08" version="1">MSSSAPWDYIAKLVCIGDSGCGKSSLTIRLCEGRFVTHHDVTIGVEFGSRVVPVGPPYSTDAATRQQQQPQQPQQTPDPNSQPSSDGPKGLPSPPIAPRDKSSPPPPPQKHMKLSLWDTAGQETYKSVTRSYFRGASGALLVFDLTRRSTFHHVTDWLNDLRQIAEPDIVVVLVGNKADLIPPEGGEEEEEEEEEEGAGEGETGAGSGSGSQTTQTQPPPPTTTGTGPGTPSKQNTSGGPPRREVSRSEAEAWARQNGILEYIETSAKSGENVERAFMRVAERIFQNIQAGKYDLNDRRSGVKSAGAAGGGGGGGSNQPVRLTTAGGQQGRGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPE4</accession>
    <name>A0ABR3VPE4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="257"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="842" mass="89695" checksum="B57CA89C1CF710C0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPG2</accession>
    <name>A0ABR3VPG2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="129"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="686"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="748" mass="81163" checksum="B888EDBB7A9CAD54" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPX9</accession>
    <name>A0ABR3VPX9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1843001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="83849" checksum="7605CA5FB361D12F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ66</accession>
    <name>A0ABR3VQ66_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="158" mass="17734" checksum="195E283ECED326B5" modified="2025-10-08" version="1">MISTCGCFKLSVYFLTFPFSFSSYFSCFRISFRSRDFISFRRSGKGVVFSIGRSVGRSVGRWARRRRALAGMGSTTAFGRRRSGAWKQADGTDAGFLCDVVLYFFSAHGHGGARFLYRLLRPLLACLHRMHLLGSAMAGVLHGWMGDGMLGCWFLMFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ68</accession>
    <name>A0ABR3VQ68_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="132"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="299" mass="35206" checksum="2C7F440200D5FB3B" modified="2025-10-08" version="1">MQSSSQPETEEAHQPRPPPWWRLKEVEMDWPQEIPKVSLLDAEALIKTGRSVMVEEGDSWDEVEDLFTDRRHPTCRRLRDIPEDEFKLGISEGKKPDPWLLARNGLNSLTVEDLVRLQTASSTGISGLFHWNSLPEHIRAKIISLTWEPRAIIIMERTAHIFTWCYCYMIKIRSKPPVSLHINRESRKLTLEHYQPIWITRIKAVSYIRKETDVVFVQFHNKSLTRIRGVYLENGEPDYTTSRDKPSPLCKKYLRAIYVTQYMRLLGCQDLEEEKKLFDRRYTQAAEYYLWSLQGAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQD3</accession>
    <name>A0ABR3VQD3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="190" mass="22290" checksum="A912130853154929" modified="2025-10-08" version="1">MDVPDEPTTPFGVVSAHTSRLQRQYQALLDKSTPYVLYRWIGTGVGLIIFFLRIFIAQGWYIVAYALGIYLLNLFLAFLQPKFDPSNDALDNEMEDGSVGTLPTKQDEEFRPFIRRLPEFKFWHAASRAIAISFVCSWFEVFNVPVFWPVLVMYWFMLFILTMRKQIQHMIKYRYVPFTVGKARYTKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQV2</accession>
    <name>A0ABR3VQV2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="158"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="748" mass="80423" checksum="B298D0B56067DAAD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRE7</accession>
    <name>A0ABR3VRE7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="157" mass="16939" checksum="B819CF4566FFC8AE" modified="2025-10-08" version="1">MQNNILFDNIYIGHSVEDAKKFADETFFKKHVVETALEEAEKPKVEDKPLSPNDLKFLDDPKKYITEKLDLFLTIAKNNPVEAIKFVPEIAGGLAAILVTIIAVVVGLLGAGSAPAPAAKKEKTDAKDKAKDKDAKASATGADTGKEATKRTTRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRI8</accession>
    <name>A0ABR3VRI8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="907"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="813"/>
            <end position="899"/>
        </location>
    </feature>
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            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="873"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1169" mass="128376" checksum="99743149BEAD4E4E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V123</accession>
    <name>A0ABR3V123_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_6738</name>
    </gene>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000668">
        <property type="protein sequence ID" value="KAL1835431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="59" mass="6507" checksum="D8631191E9831F7E" modified="2025-10-08" version="1">MEVIDGVEIPVTAMPGLQLQVQRVEYAPRTNESSFPTSFEKTAEMAPRCEPGPPDSEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1H5</accession>
    <name>A0ABR3V1H5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbohydrate kinase FGGY C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000582">
        <property type="protein sequence ID" value="KAL1835633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="276"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="678"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="930"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="709"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="974"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1755" mass="188895" checksum="65DAD99F3176C9A6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1K5</accession>
    <name>A0ABR3V1K5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000569">
        <property type="protein sequence ID" value="KAL1835673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="6">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="7">
        <location>
            <begin position="333"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="525" mass="58415" checksum="416A06E29A10D4BC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1M3</accession>
    <name>A0ABR3V1M3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RNA binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000566">
        <property type="protein sequence ID" value="KAL1835685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="253"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="11">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="11">
        <location>
            <begin position="426"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="555"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1835685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="65409" checksum="B907379098454CA8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1S7</accession>
    <name>A0ABR3V1S7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 9">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6197</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 9"/>
    <dbReference type="EMBL" id="JAZGSY010000557">
        <property type="protein sequence ID" value="KAL1835709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032005">
        <property type="entry name" value="TyrRSs_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16714">
        <property type="entry name" value="TyrRSs_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosyl-tRNA synthetase C-terminal" evidence="11">
        <location>
            <begin position="479"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="616"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1835709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="702" mass="79112" checksum="0F3682C6D108C9E3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V298</accession>
    <name>A0ABR3V298_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000689">
        <property type="protein sequence ID" value="KAL1835398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="849"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="904"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="541"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="849"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="969" mass="107222" checksum="CD11895A0AAD182C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2R1</accession>
    <name>A0ABR3V2R1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000472">
        <property type="protein sequence ID" value="KAL1836059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="424" mass="45174" checksum="BCA528913E176A6E" modified="2025-10-08" version="1">MTHPDHPISTPPRPPSPVQGFGTLAVHAGSPHDPSTGAVIPAISLSTTFAQTSVGKPVGSFEYSRSDNPNRANFETMVAALEHAKYALAFSSGSAATTVILQSLAAGSHAISVSDVYGGTHRYFTQVAKAHGVKVTFTPEIEVDIRDHITEATKLVWIESPSNPTLRLVDIRAVATQAHEHGIMVVVDNTFLSPYIQNPLDHGADIVVHSVTKYINGHSDVVMGVAAFNSDDLLRRLAFLQNALGAVPSPFDCWLAHRGAKTLHLRAREATRNATAVAHALEASPHVIAVNYPGLDSHPHRAIAKRQHRDGMGGGMLSFRIRGGHAAAERFCQLTKIFTLAESLGGVESLCEVPSSMTHAGIPRDQREAVGVFDDLVRISCGVEDAEDLKKDVLQALERAVAEVEGGGKTVPEKANGVNGLNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V335</accession>
    <name>A0ABR3V335_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000460">
        <property type="protein sequence ID" value="KAL1836135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35309" checksum="FC4D700626090966" modified="2025-10-08" version="1">MSGRGGRGGRGRGGPMVNGRRAVAQNSVPWATDTEILLDGKPSELFPPYDVPKPPPLTRKEDKVISYFLLFREQCQDGPLYTQARSRLSQTTTSSTNPSASTATATTSRAYGQDQINQRYGQVSKATVDAFTAVPTYSQRFTRAPRALPDLASRPFAKEFFPPELHATLDGEDEVAASRPGKRRRLAGGGKTLGLSNITSYKTAEELFLYDGLLPDQQQQQQQQIGQPNGRKQEGELDKALQLMSTLEKRGEGEDDAGFLSGEDDEDWVRGGNGEDDEDGVAEEDDQYEDESGDDYNAEAYFDGNQDDDDFDDGGDDGGDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V399</accession>
    <name>A0ABR3V399_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000440">
        <property type="protein sequence ID" value="KAL1836258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="120" mass="13564" checksum="C32D282EC60863FF" modified="2025-10-08" version="1">MAETPQTAPDMEARRPTGSVGTQTDEEQAPQHEREKVIDTAERVNRTTQLVQRAPSEEAKVVHAPRYDVAPQHQDNDRGGAPAVRLDMDLDIEVNLRAKIKGELELSVLDSEQTRRRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3D0</accession>
    <name>A0ABR3V3D0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000442">
        <property type="protein sequence ID" value="KAL1836240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="227" mass="24074" checksum="88A071C6138459E5" modified="2025-10-08" version="1">MHDRTHPFLQQVPLTVSPFVNLPTATTLPYRYKPMPSTLPPSILGSLATVDSDASSSTPDPQTTTGNESHKPKYVTSPSGQAAHPDDILASCRALHDHVSRLVAQAERDLAAADERIRARELAEKRRVAPGWLDSDARLLEPERPAGLAQEGNGGSAAVGLGLSGAGEMLQQQQQQQQYQSVQGWSAGYGDSFADGTAGLSEMEVPDTGEQLDRAFGSLGLGGSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3H1</accession>
    <name>A0ABR3V3H1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000431">
        <property type="protein sequence ID" value="KAL1836310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="253"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="253"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="328" mass="36671" checksum="40187A4236BA3104" modified="2025-10-08" version="1">MLLPVASRAAARHVSVWSAHRLISHFASSRVVASRVVPTGFRVVAGFSRTYAARAKAATKKTASSKKAAAKSTKKGATTKKKTATKKAAAKKPAKAKKKKAAKPKAAKKAGRKPKKQLTERQLALLEKKKIRELKQTALLKSPVAKLPESTFTVFFTERKDTYFPKGQEKPNAIEALSKARADFKTLSAAEVERLETTAKTNRAANEAAHKKWLSTLKPQEIYNAQRARMELSRKGVSLSGRRLPSLDDDRVPKQPIVAWIRWLQANYEKLRTIESSTERVRQAGALWRELSPAERKPFEDAYQADLAVYLKEMESFRKHPYRPNPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3U2</accession>
    <name>A0ABR3V3U2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000409">
        <property type="protein sequence ID" value="KAL1836449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="98"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="247" mass="27114" checksum="D49B61AFB3A89AD3" modified="2025-10-08" version="1">MTDSEFRPALLVVDMQEDFCPPSGALAVPSGRDIIPLINRLLALPTIPLKIATKDWHPPNHVSFATNHPLVDVADPSSSSSTKRPFLDTTLITNPLNPSEQYTTRLWPVHCVQHTPGASLVPDLDASRLHHVIEKGTNPAVEMYSAFYPPLHSPRVSDSGLAALLREKGTTHVYVVGLAGDYCVRSTAEDAVREGFVAYVVEEGTKAVDPWLWEDVKKEMEENGVKVVSVDGPEVQRLFAGVEEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4J3</accession>
    <name>A0ABR3V4J3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000422">
        <property type="protein sequence ID" value="KAL1836366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="319" mass="35372" checksum="D1DC2B1AA7E4D57C" modified="2025-10-08" version="1">MQKPYTTTTTNSSSSPLPPAPDGPEPTIHPIFEPQTCTYQYVVVDPATLTAVIIDPVLDYDNKTRTVSTTAADSLLSLVREKGYTISHILETHAHADHLTSSFYLQRKLAESQGTKPPVCIGRRIGQVQVLFGQRYGIESKEYDGVFDVLWEDDAEFEVGKLKGRVIHLPGHTPDHVGYWIGDNIFCGDSLFHPAIGTARCDFPGGSAQAMYASAQKLLALPDHVRVWVGHDYPEQHPEHPEPEAVATIGEHRARNKHVRHGVSEQEYVAMRSERDNKLAAPRLLHESLQVNIRAGQLPKANEAGLRLFKLPVKIPEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4J4</accession>
    <name>A0ABR3V4J4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000382">
        <property type="protein sequence ID" value="KAL1836660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046974002" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Mid2" evidence="4">
        <location>
            <begin position="147"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="259" mass="27211" checksum="BAE3C263561E647A" modified="2025-10-08" version="1">MQLRRALRALVLGLSAMAVAEATFGHLQPVARDGKALQQRRPDDDDPDTTTSSTTSRTTTTSSTSTETTSSSSSSSSSSTSSTPTEPTDATTKPTDPTSTKTSPTSTSDAEPTDPPETTEPPETVTPTTYTVTTVFTSTRDDGSEVTYTTETQTTVTPGLANPGNGNNGNSGLTTQTRNTIIGVVVGVGGAIILGGLALVAWRIWGRKRHQEENDGLMDYHSAVDSNPQTVGSMSTRTPFQSTLESYHTPTQVNTAANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Q5</accession>
    <name>A0ABR3V4Q5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Cutinase</fullName>
            <ecNumber evidence="3 11">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_5224</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 11"/>
    <dbReference type="EMBL" id="JAZGSY010000418">
        <property type="protein sequence ID" value="KAL1836386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046695841" description="Cutinase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1836386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="230" mass="24448" checksum="A907E5358F51EBC7" modified="2025-10-08" version="1">MKFFNILSIASLAAALPTTSVSEGEHAEAARIMARQLNTIRNDLERGNANDCPRAIFIFARGTTEPGNMGITTGPILAGALEDNFRRDIWVQGVGGPYEASTAPNFLPRGSSEEAIGEAKRLFALAQSKCPNTAVVAGGYSQGAALIAAAVSDLRGATQEQVKGVVLFGYTKNRQNNGRIPNYPAERTKVFCNIGDAVCDGTLIITPSHFLYNIEARGEAARFLTARVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V521</accession>
    <name>A0ABR3V521_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4545</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000357">
        <property type="protein sequence ID" value="KAL1836865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="224" mass="25045" checksum="8E93AC566A62552A" modified="2025-10-08" version="1">MATTPSQGWAQLRQQARSLESQTAIPPKPTEDEKKAEARVQELLDKRETVIAQLGRLLDSEATFTSSALKQNNLALLRDKLADHRRDLGRLRTNIREARDRANLLGSVRDDISAYHRANSNSPNSNNNLTGEAAEADYMLGERARLDRSHDVADSVLSQAYAVRDSFTRQGEVLASINRRITRAAGQVPGINALIGRISSKKRRDGIIMGGFIAFCFLMFWFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V547</accession>
    <name>A0ABR3V547_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000398">
        <property type="protein sequence ID" value="KAL1836536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="225" mass="23523" checksum="38065823F563520E" modified="2025-10-08" version="1">MAPTKPAAEGGNLANPLGLGWDESGRRVKTGRITKAAPGHIDAPVTIDDSSDGESDSAVPTTKAMGKKPVKVTKVAGKRKTPARRPLPATKRTPAGPGIHLLPACAGCKKAKTKCNRRSACERCIRAGIASECHGGDTGPGGRSKTACTRCHKSKAACVWKVTCARCDKKGVECELPPPKEKKASAAGGAAKARAVEALQREESPLESPRSPIDDEDEEDWVGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5K1</accession>
    <name>A0ABR3V5K1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000335">
        <property type="protein sequence ID" value="KAL1837042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="61384" checksum="642B4F65EFD20CCA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5N5</accession>
    <name>A0ABR3V5N5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000372">
        <property type="protein sequence ID" value="KAL1836731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="96"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="429"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="84950" checksum="030C91EBE75E3E98" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5T4</accession>
    <name>A0ABR3V5T4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">VTJ49DRAFT_4225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000326">
        <property type="protein sequence ID" value="KAL1837127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="256" mass="27643" checksum="81FB9E71F7FA3854" modified="2025-10-08" version="1">MLIKWLVSTAFGIDTNPQNNQTPTPPSSTTPPTPASGTPPSTSQSTTTPTPTTPPQPASKYAAPLDERPPYPDILSRRSLRQLGLMLGGAGFLYWSVMVSRRAAVRHHLASQLRFFTGHHEYLALRGMGLKDLPHHPSLPSIGQRREPFLAVEALGLASLNLMSFAIMAVGGLSWAFDVSELEDLRKYSRRSLARSVERQIMREAGEGGNSEDAEAESDVVEWFGRTFGVMGGPGEGAKEEKKEGEGGKGGDSKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Y5</accession>
    <name>A0ABR3V5Y5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000321">
        <property type="protein sequence ID" value="KAL1837174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF13">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="569" mass="60352" checksum="1129F33C6650F958" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Y6</accession>
    <name>A0ABR3V5Y6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000321">
        <property type="protein sequence ID" value="KAL1837177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="547" mass="62664" checksum="773F91B4FE86FAC4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V611</accession>
    <name>A0ABR3V611_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000321">
        <property type="protein sequence ID" value="KAL1837170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="141"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="421" mass="46449" checksum="4B173CAF31CCDB70" modified="2025-10-08" version="1">MVNSTAILVPCLVVAVPFIVYFGFLGLVTIPWFQRNVIYAHKIHSLWWGNINEPEQWGFAENQVTPFRITTPDGESLYAWHVLPLSIYAQHESTLSSQPGGLSPDITTTENFRLLRDDPNAKLIITSQLTQGYRPQHYHTLTGPHSPYHLLAIDYRGFGLSSGSPTESGLALDAEAAVRWAVETARVPPERIVIVGHSLGTAVTAALMERLILGSATASGSSCSSPASNSDPSGSELTRDDDTSWNFAGIVQIAPFSSLPDMLSDYAIAGLIPVLRPLKWAWPWGVRKLLSRLVDRWDSAGRWRRIARAVSERGGRLRITFVHAKNDRDIPPKEDDLLFQAVVEGMLGGDRRWDDGEGFEMEKKKRVVVKGKNEFVAEWREGDVVVRQELVPHGGHNAVLVSAPVLLAVARSFDSDAESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V686</accession>
    <name>A0ABR3V686_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000314">
        <property type="protein sequence ID" value="KAL1837245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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</entry>
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</entry>
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    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
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    </feature>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        <source>
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        </source>
    </evidence>
    <sequence length="331" mass="35929" checksum="50048EEE2824E092" modified="2025-10-08" version="1">MSAACHPPGSADLYGLGIRLSFYLLWFSVLIGERLHERHAQVPRAVELVFAYAVALGLIMAASRGVITPVDAYAALLLVSTTVYLLVPRAMNVLLMLALLTGGAVVGAMKAGLRRRKKSRRRRRANQAKIRVLRDIETFGGLIVASVLVAAIELTIRWNHVPSDVYHLDTASQLIPLGLVIALIITFLYDLRHGIPGREEASIGSSSNSSDRHSRGHSRGPPSSPGDWSSVAVHPRRSCAGTEPSPFLCGARPGSEPPSSFTSCFRTPEPSPFSSDGFKSSKLQPSSSCFRTAQSRTTSRFPSSQFFQSSSPCFWPTKPRSASCVPRSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6V6</accession>
    <name>A0ABR3V6V6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GPI ethanolamine phosphate transferase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_3693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000287">
        <property type="protein sequence ID" value="KAL1837508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="653"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="888"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="972"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118235" checksum="73B5180EEA19CD2B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V709</accession>
    <name>A0ABR3V709_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="8">U1 snRNP C</shortName>
            <shortName evidence="8">U1-C</shortName>
            <shortName evidence="8">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000282">
        <property type="protein sequence ID" value="KAL1837564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="244" mass="23933" checksum="6B35A1429417A304" modified="2025-10-08" version="1">MPKFFCDYCDVYLTHDSMSVRKAHNSGRNHLRNVIDYYQQIGHEKAQSVIDSITSSYAAEGQAHANPMLPHNQPGGGSFGLGPGHAGLVPPSIPFPGFPGAPPPPPGMPAPFPGAGAPPFPPPFPIPPTAPAAAAPGGSSASPSTPAPPGSSAAPPPPPGQFPFPMPPPGLPFPPPPPGAGPGAAAAAGRAGAAPPFPFPPPGAPGAFPFPPPGAPGAAPGGFPGFPPPPPGAPGAPGFGGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7B3</accession>
    <name>A0ABR3V7B3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000308">
        <property type="protein sequence ID" value="KAL1837316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="636"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="94256" checksum="E71564432825CF44" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7D5</accession>
    <name>A0ABR3V7D5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_3974</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000305">
        <property type="protein sequence ID" value="KAL1837331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="115" mass="13151" checksum="0A2A58F39A814932" modified="2025-10-08" version="1">MAVFQSKKYRSAAAANTLGAKYRAMMAKHPFLLFGLPFMAVIVGASFVLTPATAIRYERHDRKVRQMTREEELGVGKSGRKVDIREEYYRLAAKDLDNWEQKRVKRLKGESDGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7F6</accession>
    <name>A0ABR3V7F6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000338">
        <property type="protein sequence ID" value="KAL1837018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="220"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="343" mass="37657" checksum="BD8668D37E048D47" modified="2025-10-08" version="1">MEPRIALDGHPIGWLPAELTRPGDPLVVDLEEREVAEVEAALETCKFDPDDISRKTFVLPTLQAQLERASHQVHQGRGFVIVRGLDPRKYTAEDNVTIFLGVASYIGEQRGVQDKKGSMLTHVTDSKVWTTPPEMRHGIHTTTGLAWHCDMGTDVLALHVRSKAQTGGDTSVNPPKYFVAPLMHVSDKVLISVDPGRLGLHPATAVVDGEAPVPALTRPQLMALEVLSQLASTFRHRLDLQQGDMVFINNLALLHARDPYVDPEHGPGRHLVRLWLRNPDLAWNIPSSMRVPWEAAFGSGGLSTMKKTYPALPSLVYKPPRYTAGSAAFILDDSEDVNSGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7F7</accession>
    <name>A0ABR3V7F7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000269">
        <property type="protein sequence ID" value="KAL1837720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="185" mass="19038" checksum="6525251A61DA32E2" modified="2025-10-08" version="1">MKPAYLSLALFAVLGSAQNRRHPRDLRRRQLFRDAGRGPVIISSIVESTDLGETASTTLSSSESVDLSTSDTVAAITTSTESTLTTSTTESEAITTSESSTSTSESEAASTTSEAAELTSSASDLSVSETSSTATESVTESTATESATESAAESTTTESATESATESAAESTAESTATDQQLIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7M9</accession>
    <name>A0ABR3V7M9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000267">
        <property type="protein sequence ID" value="KAL1837727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="365" mass="40638" checksum="41AC8C95B340D16D" modified="2025-10-08" version="1">MPRNGSAKSRASEPDAISELRARHPHQQPHEESSSSSSDQDEHQDPAPTTTTTRARRPSTTELLLHKAAELETTIATALTHLLHWDDLPAWRRDNPSILRGYRPTSNSFRASLHSLLHVHNETVNIWTHLLGCLAFFGVGVRWLVREVVAPRYETATSGDAVAFGCFFAGATVCLGASAAFHTLSNHSERVAKWGNKLDYSGIVFLIVGSYVAPLWYGFYCEAGLLTLYLGLISLLGLGCLVVSWFDHFRMPEWRPYRTLMFVGLGASGVIPILHTLTRSSFADLHQRMGLGWVLLQGILYIIGAFIYAVRFPERKWPGVFDIWGSSHQIFHVFVIVAAATHLYGMIAAFDHHHGIRLAQCDTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8F0</accession>
    <name>A0ABR3V8F0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000243">
        <property type="protein sequence ID" value="KAL1838025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="213" mass="22819" checksum="A1181CC1060FB228" modified="2025-10-08" version="1">MPMLTSSPIRYPSSSDEEVIQWRREVAQLAAMLVDSSESSNSASDSESDDDIPATGAAKHKRALSVSGITVAGSVPNSPMSVQNDGVADSGSGEDTNESDDDDVPELCFGRPVTPDSSDDEGLVRNRPVSPVIGMDNDMEIRGEEGADADVNLMDIPMTSRSPETEAGEVKTGALQHVLDVLRLQDSELCDLKMAVERIRREEVADVEKKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8G7</accession>
    <name>A0ABR3V8G7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000266">
        <property type="protein sequence ID" value="KAL1837746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="70" mass="7797" checksum="03298C7ECEC4DA20" modified="2025-10-08" version="1">MSDQVQEILDVPREFLKDGIQFINRAQKPDRREFIKISQAVGVGFLVMGAVGYFVKLIHVPLNNILVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8J9</accession>
    <name>A0ABR3V8J9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000255">
        <property type="protein sequence ID" value="KAL1837887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06185">
        <property type="entry name" value="PDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052353">
        <property type="entry name" value="Benzoxazolinone_Detox_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="Tri_helical_YiiM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212:SF2">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="YiiM_3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="5">
        <location>
            <begin position="48"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="303"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="4">
        <location>
            <begin position="553"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="638" mass="70208" checksum="3AE773B56523BE31" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8V0</accession>
    <name>A0ABR3V8V0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000228">
        <property type="protein sequence ID" value="KAL1838245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="191" mass="21670" checksum="A5D42076FA12C509" modified="2025-10-08" version="1">MPENTVQDSDQSGQAPKHIAALAEHLSDMCDEAARGLQDLANLRHEGHQNNETNEAAAHATGRLDRVAEKQLEFAELMLRIHRELIPEPSEQDVGYRQGMCWAIARAKDTNNDMVDILHDRLERQEHAPILCREIVFIDVDILLLASTSGPVDWVSRTGGGGGMLNLLRPRSEQEWRINQYLEQYLYFKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V925</accession>
    <name>A0ABR3V925_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sde2 N-terminal ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="10">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="108"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36736" checksum="854422D5D83FE0AE" modified="2025-10-08" version="1">MAPSKINVLITSFPGTGFPSTLSLALPPTTPISTLADELDSRLPPNAPIDHLLLTTLSNRPVPLYSTTPISSLLPHHAFPSQFSSTDAITSTLQNDFLTLRLTSPLPGGKGGFGSQLRAAGGRMSKKKKNANGQEDNGSSRNLDGRRLRTVTEAKALAEYLAIKPEMERREKEARRKRWQEIVEMTERRQEEIRNGGSGNKGLMDGKWVEEKEEVGERTREAVLEAMRRGGYRDNLLLEVGDSGEGSSSSGAGLVGSGASSEGDEVDEEMRDEEEEEEESGGSKATTPPSEPEPPVEGKGKGKEKEVVKNNGNGHGNGAPPVKKFIGFDDDDEFMSSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9C5</accession>
    <name>A0ABR3V9C5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_2923</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000229">
        <property type="protein sequence ID" value="KAL1838225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="15">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="16">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1838225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="358" mass="38596" checksum="E0BB4697C4A1EA2E" modified="2025-10-08" version="1">MASTVEKFVIKTPCSSANIGPGFDVIGLALSMYLELHVTIDRTKTSSTHPLNCRITYEGEGEGTDEISLDPQVNLLTRVALYVLRCHDQRTFPLETHVHIKNPIPLGRGLGSSGAAVVAGVMLGKEVGGLHHLTLERLFDFCLMIERHPDNVGAALFGGFVGTYLMPLAPEDAARVEVPLSEVLPAPAGGVDTGVRPPEPPHGIGHHIKFPWAPEIKAVAIIPEFEVPTAKAREVLPAQYPRPDVTFNLQRIALLPVALGHSPPNPQLIYLAMQDKLHQPYRQTLIPGLTEIVASMTPASQPGLLGVCLSGAGPTILALATSNFDEIADRIIARFKQNNIVCNWKLLEPAEGTTVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9E3</accession>
    <name>A0ABR3V9E3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000217">
        <property type="protein sequence ID" value="KAL1838385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="48"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="200" mass="22487" checksum="DE8E470F828E332D" modified="2025-10-08" version="1">MALFTRGFYDSDPSFTPLFRLLDEFDNYTREVRGYTDNNDRPRHRGRGHLSTFNPRFDVRETDQAYELYGELPGVERDKINIEFTDPQTLVIRGRTERNYTSGTPPAGLVDKGTQPAGAITENGETPAPAAESNGTTERTTKAPSEKYWLQERSVGEFARTFSFPARVDQDAVTASLNNGILGLVVPKAKKHETRRIAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9G7</accession>
    <name>A0ABR3V9G7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000211">
        <property type="protein sequence ID" value="KAL1838484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="45"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="322" mass="36090" checksum="162470A4A9A90257" modified="2025-10-08" version="1">MPGPPQNIPSSTAAFPFITYTTRDGSSASGSTAGCSPSAPNQPNEQLESPLFGMLPAELRAMIFTELFGGRRVHLEFMTHPLRADKVGNRRRWRHGVCEDDPSSVPFSRVAARQHYCLTAARRRVLDISMLFTCRRALVECIPILYQRNVFLIINTGSRRLPVDDIRSLQAKVPKHWPLIQSLEIKWEVAPFDRNQASMVPHFGGRDAYEAFWDALAEMPALTRLRIALLMPRWSPTHLTPSVVDLRESYLGPIGRLKHLRVCEVIMPKSYMSLFGDDECDSFVATPGGLRHRISWVDDDPGSLATGPAMANIFHLLPMALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAH7</accession>
    <name>A0ABR3VAH7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_2260</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1838723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="73" mass="8461" checksum="3385C97109B08004" modified="2025-10-08" version="1">MQESPHEHQQNLLLSRIITNVEKLNEAIVVMNKTLQTINIQNMNIELVAQMFKNYQSNVLFHLEATDNLKDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAT7</accession>
    <name>A0ABR3VAT7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047483383" description="Fe2OG dioxygenase domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="131"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="275" mass="29962" checksum="F7E579584F89DDAE" modified="2025-10-08" version="1">MPSLTCLTLAALGGLAILPGAAASKQTLLKTDDYVCEHPPYKPRIVSKSPLVIYLENFITPSERAYLLDLGKSTFTPSGITNRRGNANTDTTSIRTSHSTNLPPTDPVVSCIESRALRFQGLPTTTAARSRLEPLQLVKYEPTQHFHFHTDWFTSPSDAAPEAGGNRATSFFAYVHVEKGTTGGGTNFPRLTLEADEEEEWCEEGLVDCDAEREEGVTFRPVEGNAVFWVNLDQQGRGDERTLHAGLPVVTGGKVGMNIWTREGDVGEEIRGGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAZ2</accession>
    <name>A0ABR3VAZ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000187">
        <property type="protein sequence ID" value="KAL1838888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="79794" checksum="C052E0AF76886CDB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB40</accession>
    <name>A0ABR3VB40_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000181">
        <property type="protein sequence ID" value="KAL1838992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="195"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="454" mass="49129" checksum="393441E091B65F8F" modified="2025-10-08" version="1">MASRKSAHQVWHVSRGIVFSGGTTVVYPRLPPARYYSPAAAAAVSEGSSSPSVPTMPPPHSVPAAASSGHESPATVKSEVVATLLEARTTVTASASSTTVTASCSTATTTTSTTVLVKDAVAKDEKSAAENAADKPAQEKTTPVVPPYTPLDFKIPDKAFQAARNAAPGTPQSYWNYSLYRGPSESGALDAKVKVHYCTSSRTTERVVKEHFLHEKVVGFDLEWMANATKYSGPRRNVSLIQLASPSRIGLFHVSAFPRNDTLVPPSLRKLLEDSEITKVGCWIKGDCTRVANYLDVRVRGQLEISHLYKLVKYSKTGEYGQINKKLVRLATQVEECLGLPLSKEVDVRLSDWSKPLSMAQILYSSSDAYASVQLYHVLNHRRQQLEHVPPLPHHAELDLPIPFVVPPSPKKTEGAAKLPPKELINNNEINPAAETGLTNPTDSAPPPTNVTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBC4</accession>
    <name>A0ABR3VBC4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000173">
        <property type="protein sequence ID" value="KAL1839145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="259" mass="28461" checksum="F2F6FCBD2D4565A7" modified="2025-10-08" version="1">MPRKHTKKPSRTHRSTLSLQKTEILINVYDLLPPGRLSTLLWHLGTGLLHSGVVINNREYAYGGHDRPGLTGVYWTRPRVEPPGGTFRCEILHGFTLATAEEIDAIVREASDEFQGTGYNLLTRNCNHFTSYLCERLTGEPAPAFLNRAASIGVALPCVVPREWVEPPDFETADGELMDDGGQAHGRGEDGSGQGERDRMLRSSEEVPRLVGQEEEEQDDEWVGEEERERGGSGKGKGKAPVRDAAGRALPPAERAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBF3</accession>
    <name>A0ABR3VBF3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="166" mass="18412" checksum="CE78603699C5600C" modified="2025-10-08" version="1">MLFPGMDSMASPVSVPPAGDVLGTSSTRDFAAPPRVAYTPGGASTPSSTRTNMPLLPTTNPVSPVMYHDEKNSLHSKWRRFLTRLNEIMLGKDEKASVYWYASLLSVLAALIVTGSSIFGWPPLPIWDFPPYISQNVDVVVGLAKNRSRLLLRRRLLPRRRRPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBH5</accession>
    <name>A0ABR3VBH5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000209">
        <property type="protein sequence ID" value="KAL1838518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="194"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="833"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="965"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1054" mass="115907" checksum="8719ED0BA240C26B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBJ7</accession>
    <name>A0ABR3VBJ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000169">
        <property type="protein sequence ID" value="KAL1839219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17537" checksum="6CFD6C98F8D2979D" modified="2025-10-08" version="1">MLKHNKLDLNKCLGVDKNGDLIFKKKGYFEQFCQRCSVTVDGQLHCECFRYGGGSNSIAPHPYLPTVSIPPVYRPKTSLANMRPYALFTVAAALLLSLCTADYVNFSRTCTDFLLVDGSILEASCCYPPCEPGMSLINRLNLNQCVGNNPDDYGHLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBN0</accession>
    <name>A0ABR3VBN0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000206">
        <property type="protein sequence ID" value="KAL1838578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032382">
        <property type="entry name" value="AltA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16541">
        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046145740" description="AA1-like domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="AA1-like" evidence="6">
        <location>
            <begin position="54"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="192" mass="21290" checksum="AF413A90F775AE08" modified="2025-10-08" version="1">MHFRASLAASLLGLAAASPIASPDPADASPKGCSDISFKNFSWEAQNVYFHASYIFTTPAHQNSWGYISFDLFNPADESTAHCEAASNQLSDFFYGTVQYTCDDTLRVGQTSFDFSRPGNRLRVEQNWTCDDQDPQYPITFTARGDVNLTLSCTDETWENPDWEMGQIYSSRAIECQPVDSPILPTEISAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBN4</accession>
    <name>A0ABR3VBN4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000171">
        <property type="protein sequence ID" value="KAL1839187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF5">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="200"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="251"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="909" mass="98670" checksum="09958CF4267C64FB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBS6</accession>
    <name>A0ABR3VBS6_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000168">
        <property type="protein sequence ID" value="KAL1839232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="233" mass="26132" checksum="0CE9F7AEF63EC576" modified="2025-10-08" version="1">MAVPANAAVRETRRRSTPSDVERLNVNKALTTAEYSRRQFILNFAASRNTQLLIPGRKSEAIKAAEQWTARHLHQNGHHVQNNDLFKYTVDEHLWATHVGDDIPFPFTFMHPQLASFNEPAPTSPVEFHERLFDSKDAKTDSPQTSASAPLLAEVQSSDPATTQLRRQASTKQPQRQSESSLSPDIKRSMSLSSVDELKAQPKLAPEKSPFFVRLGRGAWRDLVRGSGDEVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBT3</accession>
    <name>A0ABR3VBT3_HUMIN</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000172">
        <property type="protein sequence ID" value="KAL1839167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="121"/>
        </location>
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        <location>
            <begin position="335"/>
            <end position="394"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="10"/>
        </location>
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        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="730" mass="83882" checksum="DCFF02CAE3703DA1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBT6</accession>
    <name>A0ABR3VBT6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000190">
        <property type="protein sequence ID" value="KAL1838841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="181" mass="19263" checksum="3E51576FA8D76F9B" modified="2025-10-08" version="1">MVARGGALLLRMGKVPFFSLASRIACTCTSSARPLRSSRFFFFWCPPAPGISFPLPSPLRQQENTLCLPPPSAQSIPKTTTTTTTTTTSNTESPSSSPAAARCISIVPPPHRVPPGQLGRAAGQPPQRLTCTRSYPPSPADARPSFLWCAGFVSARADTGRRDEAGQCVLIGDVSSEVWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCZ6</accession>
    <name>A0ABR3VCZ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aurora kinase</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000142">
        <property type="protein sequence ID" value="KAL1839739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="142"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="414" mass="47067" checksum="2793558BB51FB9BC" modified="2025-10-08" version="1">MASVRTLESCFDRLSVNDENDPGQNVRPYQKPRPPVSSQLAHGSARPNLVKVALQSQNTNTVTTTVTLPSQKAAAEWKSSATLPSNPPSPRKDKEKDRTAGQLAQRSAAHSDDTSNTQASASAAPTYVDQPLVPKQFHLGMFEIGRPLGKGKFGRVYLARERTTGFICALKVLYKSELQQGSGVEKQVRREIEIQSNLRHPNILKLYGHFHDSKRIFLILEYAGKGELYKHLRRENRFPEWKAAQYTAQMASALRYLHRKHVIHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRKTLCGTLDYLPPEMIRSGSKDNWYDEKVDLWSLGVLIYEFLVGEAPFEDTPVMTHRRIARADMTIPDWVSKEARDLIQKLLVLDPQKRLPLEDVQNHPWIIKHCVKGERAANREKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDG2</accession>
    <name>A0ABR3VDG2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000167">
        <property type="protein sequence ID" value="KAL1839268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="229" mass="26034" checksum="AF7E859EF7847B59" modified="2025-10-08" version="1">MLRTRLLIAPLRTAIHRPALSSRHIRPFTAAMSTISDVVTKDHRELESYYNEIIQSNDPDHQERFGNQFTWELARHSVAEELIVYPAMEKHMGERGHKMAEDDRKEHHRVKELLKEFQSLKPSNPEYVPKLRELWGVLSAHIEEEERSDLPALEAALSKGGAVSTAGEESAAMAKTFDRTKMFIPTRSHPSAGENPYFESAMGMLAAPMDRLMDIFRKFPEQPASAGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDW1</accession>
    <name>A0ABR3VDW1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000144">
        <property type="protein sequence ID" value="KAL1839702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="45164" checksum="D842C605595E0D62" modified="2025-10-08" version="1">MAALLQPPLWDLEVEKRQEKKMICVQCDETKQLVCPPCEPGTACQIIQPTDCTECRRTVCVPIDPIPGTGTNTSRSTNVGAIAGGIVGGLAVLAVVTYLVWRFCIRTRRQPVATEAWDDGQDDAVAREKSFAQQRDLRASTHARNSIASTVLTRASNIIQIAYIPGVTNRAAPSPSVLVPPVPPMPMGLSPAGTPRSTEDEHFFVPGDLRDSTYSGLSAFSDRTSYARTSYAPRSSVASTIYGKSAVIVAPAQTGMRAKPAMVSVRSAHSNHSNGTSTPPVPAVDYEKYNLARPPSPAGSTFSVGSTFLNNASTATAVPARAMVVRVGSVKKKGDKKTAANTTPDSESVLSPTVSGSTARNSSAPTIIVDSPQIESPFVDPPLSASQSTASLSAVIEEATRRASQRDSTLPPEKDRGGSPFGDEHATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE58</accession>
    <name>A0ABR3VE58_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000158">
        <property type="protein sequence ID" value="KAL1839416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1072" mass="120093" checksum="B2279776D63DFA11" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE93</accession>
    <name>A0ABR3VE93_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000138">
        <property type="protein sequence ID" value="KAL1839837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="259" mass="28744" checksum="4D9818D9C0D8677E" modified="2025-10-08" version="1">MAQVPAQTIPRDPQLFYWILFPITIVMVLTGILRHYATVLMASSPKKLDKKATREQRSLAHGVSVRANHYVLSRSSFTARRDALMTAYESGAFLKDPDARGQPPANPMSDPAAMEGMMGMMKNQMAMIIPNTLIMGWINAFFSGYVIMKLPFPLTIKFKSMLQAGVATKDMDPRWMSSISWYFLCIFGLQPVFNFLLGSDNAANQMAAQMQMAPPAGQVFGPGVDPNKQFLAEAENLAVIEHHSVLDGVEQRLLEGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEA0</accession>
    <name>A0ABR3VEA0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000149">
        <property type="protein sequence ID" value="KAL1839583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1224" mass="135862" checksum="46B3CE531EFED1B1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEA3</accession>
    <name>A0ABR3VEA3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000134">
        <property type="protein sequence ID" value="KAL1839950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="223"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
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            <end position="81"/>
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            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="627" mass="70525" checksum="B625FB249C040840" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VED1</accession>
    <name>A0ABR3VED1_HUMIN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000123">
        <property type="protein sequence ID" value="KAL1840185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="248" mass="27759" checksum="B953439F991C2C72" modified="2025-10-08" version="1">MADDWEDINESEVLSPSDLEWKPSPYRNEPVPIIPVRINFAKDTVLWSHRTLLQERCPKLADRIDNATLAINLSGYSAGVGHALVHFLHTWEYQRIVPTNADTDRRASRAGLMARLEACILARDLEFPAFEKKATDDLLYGIQNIGASPSLDIVKAAYPRPLSEDPEFEAVLSELSDSPILFMGDWGSLEGWLEKPRPMTPDWGEVRREHVPFAEGLRDGYRDAMIRYWNSTPGAGTSSLGSPPTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEE0</accession>
    <name>A0ABR3VEE0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000126">
        <property type="protein sequence ID" value="KAL1840126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="177" mass="18184" checksum="57D559D82D1D4181" modified="2025-10-08" version="1">MPADRQSQTSPLPAGNQSGQAKGKGKKRQAKAPSPPTQSVSQPQSTQAQQPPRGAAPQQTPHLLMPGQSSGPSRPSQPGMQQHPIAEEDDLLLLDESSLAASSQSLSQASPQGHLNSIELLLLDELDPETPQVASIPVLVPSSAGGGGSAGAPQLDASGTGQDQQGGRDEGEWLIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VER6</accession>
    <name>A0ABR3VER6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000126">
        <property type="protein sequence ID" value="KAL1840115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="75"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="239" mass="27081" checksum="517EC97BBE1DBD2E" modified="2025-10-08" version="1">MGSDGNDWVQVTRKGKRRAAPIIPDVLRPNPNPELSVNDILKYHNSLLRNTQTIDWWKRLGPALDDASRKPGSLPLITKAVCLGTGPYDPENGSITARRTAHMQTATFRHIVHHLESLSGQRIKCYIQEPRFTQVDKKFCSELELEAVDSPEGFSLVDGETLLFGIHMELEIYNQALAGQLPAVYVGSSLQEWENILGSESESDTQLTAFCEMDAKYHKYELPDFEYMFSSTVMYWRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFE7</accession>
    <name>A0ABR3VFE7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="207"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="207"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="501" mass="53339" checksum="3F9F36CF40C30D1D" modified="2025-10-08" version="1">MPTAKDKTALFKPAALLHRSPRQDSSPRPTVADPSLGALDDMQNTSFHTTNRLLATPKDPYGILGVPKSATAAEIKKAYYGLAKKWHPDTNKEPGAKDKFAEIQSAYEILSDPKKREQFDQFGAAGFDPDAAGPGPGAGAGHPFGGFGGFGGFGGQGGFGANINFDDLFSAFTGGPFRGARGGGTQIFQGEDVEVQVTLSFAEAAKGTSKTITTMPLVECRTCSGNGLKPGTQRTSCSACHGTGTRVHFMSGGFQMASTCTSCRGTGSTIPRGSECRSCHGEGVVRERKTINVDIPGGIEDGMRLRVDGEGDAPPTARAAAEGHKVRGTRGDLYVLVKVARDPRFSRQGSDILYTATIPLTTALLGGEITIPTLDGDARVRVNTGTSTGDRMTLAGKGMPKLGPRRGTGDLKVEFRVAMPKYLTSNQRALVEMLADEMDDKSAKRIMNLHKTSPDDSNPEDHRNEGFLKSFWHKFTNHPAHQQKPDDGSSSSSNDDKTKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFH0</accession>
    <name>A0ABR3VFH0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="196"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="535" mass="59435" checksum="EBCFEA2CA1CCA500" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGG6</accession>
    <name>A0ABR3VGG6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="623"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="737" mass="83135" checksum="1F5A7638F91CB843" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGR9</accession>
    <name>A0ABR3VGR9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="284" mass="32278" checksum="682FC6848F4EB649" modified="2025-10-08" version="1">MPQPLATARTALNVLSRTVPRQCARSISTAQAGLPRRPAAPRPAQLSQPQPLVQRRSFKTVEEAKSRYRSGPFSWKAGVLFVLTGCGLVWYFENEKKRMQRKRIAESTKGVGKPKVGGPFELIDQNGNKVTEQDLRGRYSLVYFGFTHCPDICPDELDKMARMFDIVEAQRPGALTPVFVTCDPARDGPKELKDYLIEFHPKFLGLTGTYDQIKAMCKAYRVYFSTPSNVKPGQDYLVDHSIYFYLMDPEGDFVEALGRQHSPEQSAKIILDHMKDWRGRWRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGX9</accession>
    <name>A0ABR3VGX9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="253" mass="27166" checksum="45E56E234CEF87EE" modified="2025-10-08" version="1">MAHRPPTRRSSHDSWVVVERIEASSFSRDRSPQLNNRNKSSSEMASVSAKGGGCSALHMHVADLRIATTQGDDDDGHHNHYDAHPVPDHDDAHGGVREEGYHIPPSNATGESWETPTLTNVAALPAAVTASTAPPPSRSPACPPLTAANMARFQRDLAERCPCGIDNWRSAAGFHLRIGHDEGRPLSPANTKWSMYPASSGRSHAPSSVLGWDYMLPPRAAMMQDPDGVVVGAGAWSSEAKRPPKSGLSDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHL3</accession>
    <name>A0ABR3VHL3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="149" mass="16664" checksum="BCF360CD256AB650" modified="2025-10-08" version="1">MPTRFSKTRKHRGHVSAGKGRIGKHRKHPGGRGMAGGQHHHRTNLDKYHPGYFGKVGMRHFHLLRNHYWAPTINVDKLWSLVPLETRDQYLSGAKADTAPVIDLLSHGYAKLLGKGRLPEIPLVVRARYVSAEAERKVKEAGGVVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHL9</accession>
    <name>A0ABR3VHL9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="8">
        <location>
            <begin position="81"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="238"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1173" mass="135601" checksum="7D70DC5F63D5F143" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHZ4</accession>
    <name>A0ABR3VHZ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7067</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
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        <property type="entry name" value="SPX_SYG1_like"/>
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    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
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    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXS"/>
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    </dbReference>
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        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="9">
        <location>
            <begin position="645"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="848"/>
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            <begin position="1133"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1205"/>
            <end position="1332"/>
        </location>
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        <location>
            <begin position="70"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="261"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="320"/>
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        </location>
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            <begin position="861"/>
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            <begin position="1269"/>
            <end position="1278"/>
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            <end position="1308"/>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="1069"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="1072"/>
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        <ligand>
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            <position position="1106"/>
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            <position position="1109"/>
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            <name>Zn(2+)</name>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841452.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1332" mass="150607" checksum="0EED2503E294E968" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIJ3</accession>
    <name>A0ABR3VIJ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1841566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
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    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
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        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="627"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="235"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="452"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1074"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1087" mass="118751" checksum="B56B15637835ECB5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJJ2</accession>
    <name>A0ABR3VJJ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="185" mass="20521" checksum="862C96FAC428DFD8" modified="2025-10-08" version="1">MSQPWPPAPASPSMPAPSRLHLIHPDLKPPAVTNALRYFKRDVQGFLNAPKPITIDKFGRALGVGRRKASVAHAWVVEGDGQVLINGKTLVDYFGRVHDRESAVWALHATDRIDKYNVWARVTGGGTTGQAEALKLAVAKALMAHEPALKPALRRAGCITRDPRRVERKKHGRVKARKRPTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL12</accession>
    <name>A0ABR3VL12_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="207" mass="23015" checksum="E5415111C460BC9E" modified="2025-10-08" version="1">MATTAQIPEGGTILDTFRRTFPTVPIDEAKGNAISTTEFLEAAEALTTMFDLLGSVAFSPVKKDMMGNIEKIRKRQLAAPLESETLQDLVRNELKTKSHTATEGLLWLVRGLEFTCLALSQNLANPTHELSDSFRNAYGDTLKPHHSFLVKPIFSAAMSACPYRTDFYAKVGSDDAKVREELTVYLAALEKIVKILKDFLNSKEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL16</accession>
    <name>A0ABR3VL16_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="225" mass="25050" checksum="A7080B58FF4C543D" modified="2025-10-08" version="1">MGRFAITRLLAPELTRQLSRAACPTTTAIPRWTRLFSHSRVTCNNTPTFTQTPLQQQQPNSDANGSAMDRIRNVFQAGANPAAAATDSLTDSLGMTDEEQSPEPYHFHIYSHKHNTHITVTKPNRDALLSLSCGNLGFRKAQRGTYDAAYQLGAYVIDKMHQKGLVKQIHKLEIVLRGFGNGREAVVKVLMGNEGKHLRQKIVRVSDSTRLKFGGTRSPKKRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLC3</accession>
    <name>A0ABR3VLC3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">AdoMet-dependent rRNA methyltransferase SPB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="11">
        <location>
            <begin position="234"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="10">
        <location>
            <begin position="622"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="784"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="734"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="94976" checksum="54F383C836CF3521" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLZ8</accession>
    <name>A0ABR3VLZ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cortical patch protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000033">
        <property type="protein sequence ID" value="KAL1842781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26638" checksum="2D3AF0E018E4AC06" modified="2025-10-08" version="1">MARSLAPVALLLLAGSLVLLWFVILSGLTRTSPLRQTYFLRADTSGIEGARPISQWTFFRVCGLDNLDCGPSRPALPLGDAWASFADNVPDELIGDFGNDTTSYSYWYMWRFGWVFYLLALFFEVVAFVVGLLALCSRIGSMLAGLVTMIALVFLSVGASLMTATFVKMRNAFRAEGRDASIGSYAFGFSWGAVAALLLATILFCASRHKSRSPPPAPGSHIPRRSYPWSRRTNRHVKSDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM10</accession>
    <name>A0ABR3VM10_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein RIM2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="53"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="170"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="286"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41546" checksum="7CAA1978BF0CBD2A" modified="2025-10-08" version="1">MTASKSESLPGVKPPATTHGDAPLTQSRETGDVNPESRQGDPIVNRDKSTPFAKSWAHMVAGGIGGMTAATLTAPLDVLKTRLQSDFYQAQIRASRAAITAPMNPVRSALFHLGETVSILGAVYRQEGPRALFKGLGPNLVGVIPARSINFYTYGNGKRLIAEYLNHGHDSAWVHLSAAALAGVVTSTATNPIWMVKTRLQLDKNEAREKGGAAKRRYRNSLDCIRQILRDEGIRGLYKGMSASYLGVAESTMHWMLYEQIKRALARREERIVRSGRPKNAWDHTVDWTGKVGAAGFAKLVAAVLTYPHEVARTRLRQAPLADGRPKYTGLAQCFKLVWKEEGMLGLYGGMTPHLLRTVPSAAIMFGMYEGILRLLNTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM52</accession>
    <name>A0ABR3VM52_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5 15">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 15">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_3901</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5 15"/>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="430"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1842884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="607" mass="66897" checksum="FB9687E4B243C6AA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM69</accession>
    <name>A0ABR3VM69_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="13">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_3456</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="13"/>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="16">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="420"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="512"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="858"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="904"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="923"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1842979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="961" mass="106909" checksum="46756F54313DAC6A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM98</accession>
    <name>A0ABR3VM98_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_3328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="58"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="552" mass="60395" checksum="61CAF45EEA35ECCE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNG4</accession>
    <name>A0ABR3VNG4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="528" mass="57473" checksum="9C67D4085EDB9BC9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNM5</accession>
    <name>A0ABR3VNM5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="115" mass="11958" checksum="33D9BE6C14DEC314" modified="2025-10-08" version="1">MQLDKLVGLAMLVASSVVFLYYTIWTLLMPFVDPDHPLQKFFPPRVWAIRIPVILILLGCAVVGSFLSVVMIRSNRKKAAKAKAAAAAAAAAAAAASADNGAGSSTSSAAAKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNP7</accession>
    <name>A0ABR3VNP7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="294" mass="32501" checksum="317159EBB1F4476A" modified="2025-10-08" version="1">MNDSPSPPPVEALLPPSPPQPPAELSSPPSEPPLRIAILLNSHRSPFLTSIRASYERAIAAVSPDAILSFFYPAESPERVTLLHGEGDLPPDPSVYDLIVVGGGNTDPRAGHAWIQRVHRFVLDCMSVSTRSGSGARPKVCGICWGHQTIALLFGGEVVEAERPELGVTEAKLTPTGRRFFASRSREGTLRLQQHHRRAVGKPPQGFSELVAGNQGFLSHDNTILTLQGHPEKDAQCARLRIHDATRWYGLREDDEAARSAILRSMEQPHHGKEVWERILRWAREKQPSHEVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNV9</accession>
    <name>A0ABR3VNV9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="323"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="577" mass="64255" checksum="4E3011C47773B751" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP63</accession>
    <name>A0ABR3VP63_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="419" mass="46234" checksum="2BBF4B09675ED757" modified="2025-10-08" version="1">MLRRSHKKSRAGCLECKRRHVKCDEQRPKCIICTLSERECSYPPQPAVPWNAGATSSTSPAAASSLGFSNSLDAAIAAGTAGTANMANMASPVAGVPLPDLANGRPGPPQDPSSDQSIPEVNLGHMELLIRFNFEEHAPELNVEMHEFASKLLFKCALEAPYLMHEILAVSSRRLALLHPDRADRLLEEAIRLQTKAVSIYNETAAKAQIDQTNCSALLLFCSLLGRHLLADLLARRDGDFDEFLTRFLEFVSISRGLMAMSVAAWDLLLQSDIQHLVLWALEISQSAPRGHHCDGLQRLVAESAELIPSAKEACLAAIAYLQVGFDSLLGGDTRNQRYLMVFMWLPAVPQAFTDLLSQRRPEALAIMGHWALMLHYTRSLWQVGGSGVHLLTRISEHLGHDWRHWLEWPLSVLAAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPF7</accession>
    <name>A0ABR3VPF7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="536"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="757" mass="85422" checksum="6542E30CBD43508D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPF8</accession>
    <name>A0ABR3VPF8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="565" mass="61645" checksum="C2A45E3B46D132A6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPK8</accession>
    <name>A0ABR3VPK8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="323"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="815" mass="90435" checksum="053C6D8B0D79DFC4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPR3</accession>
    <name>A0ABR3VPR3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="377"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="673" mass="73267" checksum="A945556C9DC630FA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPZ7</accession>
    <name>A0ABR3VPZ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="374"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="569" mass="65151" checksum="2D390612B6BD4649" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ78</accession>
    <name>A0ABR3VQ78_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="486"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="516" mass="57669" checksum="2C6A8D23767860AF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQJ3</accession>
    <name>A0ABR3VQJ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphatidyl synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5778</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1844027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25408" checksum="4327C08450ED87B3" modified="2025-10-08" version="1">MAKARNLHENIYTLPNFLTFSRLIAAPFIGYCILHDYHATALGLFAYAGITDALDGWIARRWNLKTVVGTVIDPMADKTLMTVLTVALAMKGALPVWLAVIILGRDVALAISAIYYRWISLPPPKTFARYWDFSLPSAEVRPTTISKVNTALQLGLMGLTTLAPVVPGLEMGAALGVMHYVVATTTIWSGASYVYSKDAVRILTPPKEEAENEKAHDGSGKADKDSQRKTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQP7</accession>
    <name>A0ABR3VQP7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045831433" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="504" mass="54024" checksum="CCBAE27FE1C39C85" modified="2025-10-08" version="1">MHHPSLCAVAVALLSALPSAQAGLYTKKSPVLQVDAKNYDRLINKSNYTSIVEFYAPWCGHCQNLKPAYEKAAKNLEGLAQVAAVNCDDDANKPLCGSMGVQGFPTLKIVRPKKGGGKPMVTDYQGQRSASAIVEAVVQNLNNYVTRIEDKTLDKFLSDNKDRPKAILFTEKGTTSALLKSIAIDFSDVIQIGQVRNKETKTVQKFGIDKFPTLILLPGGDAPHVVYDGEIKKEPIVKFLSQAGQPNPVSPPPKEKKSKSSDSKSKSKSKSSSSSSTSSTASSETPAATQEVPVIVETALPIPSINTHDKLIKECLTDKSHTCVLAFVPEGGSEKARKGLESLSQLAFKYAQGKRKLFPFYEVPASNEGAEGLLKALDLPARDVEIIAVNARRGWWRHYDAADFGVESVESWIDAIRLSEGVKKKLPEGLVAIAVEETPSASSSASQEEAASEAATPEATAEGKSEEATKVTPEASREAAGESETDATQAAEPSAEPETAHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR14</accession>
    <name>A0ABR3VR14_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="11">
        <location>
            <begin position="6"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="282"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="324"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="378" mass="38979" checksum="8A4C089CC8330A08" modified="2025-10-08" version="1">MASIPHITVLGSLNMDLVAYVPHRPLPGETLTADRFATSPGGKGANQAVASKLAISQGAKLSRPRPSSSGGATTTSSSPTAHVSMVGSVGSDAHGAQLRANLTSYGVDVSGVVDAPSGTGTGVAMIIVDKPTGENRIVLSPGANHAVQPGQGQDAEEWVLRRLRVDDVPTDAPTNYEEGVTAHSVLPDMLIMQLEIPLQTVLVALAAARKKGVEVLLNPAPASPLPEEAYVGLAHLVVNETEAAILGGLGVGNANALAGDEAALERVSRGFLARGVRNVVITLGGKGVYYMSSAGGLSAEEVNVDKKGLVPAEKAKVVDTTAAGDTFVGRYALEAAVARKKGEVFDIEKAVREANRAAAKTVERPGAQDSIPWRDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR21</accession>
    <name>A0ABR3VR21_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1844207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35281" checksum="19753392BA029389" modified="2025-10-08" version="1">MTTIDSLPSEILDSIVDLFCHDSNKDDVFFSGLRTLLFGSSMTYGPNRCVNRSTLAAICLTSRRLNAAATRHLYHHLYTPRWWLLMRTLVTRPDLARHARSLRVTYATKPLRNEIRGALRKHLLARRHRQCLNRLLSPHGTRGSERLGGIRRRYTPIRRNVDDIYDHYDLFMSAALDGLISLVPQIESLGFDPQYCRHLFSFKAPLSALRHLSVTMTDWLRFFRVTPVEKAVKENLSSLAMFGLAEAGDLILNLAPRMRQVCLDVSLKTDWHGYWEEDTAKELGVKLAERGIRFEFIDAKRPNEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR96</accession>
    <name>A0ABR3VR96_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="341"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="418" mass="47150" checksum="D4002705E32B365F" modified="2025-10-08" version="1">MVIKDIMCGDEAAAARTMLQISYPMENGIVKKWDDMQHLWDYTFFEKLKVDPRGRKILLTEPPLNPLSNREKMCEVMFERYGFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLNHLTRRLDVAGRDVTRNLIALLLRRGYALNRTADFETVRQIKEKLCYVSYDLELDKRLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDCDQPGIAEFLFNTIQSADVDVRASLFKAIVLSGGSSMYPGLPSRLEKELKQLWLTRVLGGNPERLSKFKVRIEDPPRRRHMAKRLRAEVGFMPSPARYSADRSTGSMGYQSKVRVTDKYKVIGFISSGTYGRVYKALGRHGQTGEFAIKKFKPDKEGEQATYTGISQSAVREMALCTELSHENVIKLVEIILEDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRU0</accession>
    <name>A0ABR3VRU0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_60</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1844381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17751" checksum="DDD50050A1B61476" modified="2025-10-08" version="1">MSLVSGEKSNFNHILRLLNTNVDGKQKVVYSLTKIKGVGRRYSNLVCKKADVDLKKRAGELTSEELERIVTIIQNPTAYKIPSWFLNRQRDIVDGKDSQVLANGVDSKLREDLERLKKIRAHRGLRHYWGLRVRGQHTKTTGRRGRTVGVSKKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V171</accession>
    <name>A0ABR3V171_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000617">
        <property type="protein sequence ID" value="KAL1835530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="306"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="669" mass="72043" checksum="052C5D992518393B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1P3</accession>
    <name>A0ABR3V1P3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000755">
        <property type="protein sequence ID" value="KAL1835306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="2"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="96" mass="11179" checksum="C4DBDF7887D80B14" modified="2025-10-08" version="1">MFEDIPLDTRHHTFKKQIKFPKEWYLTEERKQQLLERRKQALLLDEAKRNSEGGLVDGRAAIEQALLNAPKVEQMVPPLPNGRMDEWGAIRTLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1R8</accession>
    <name>A0ABR3V1R8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000684">
        <property type="protein sequence ID" value="KAL1835406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="97"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="513" mass="56328" checksum="7195DDF96A23C05C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2C8</accession>
    <name>A0ABR3V2C8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000506">
        <property type="protein sequence ID" value="KAL1835924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="357"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1835924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="724" mass="79432" checksum="16900485B3B24B63" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2L9</accession>
    <name>A0ABR3V2L9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1858</name>
        <name evidence="8" type="ORF">VTJ49DRAFT_6266</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000576">
        <property type="protein sequence ID" value="KAL1835651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000174">
        <property type="protein sequence ID" value="KAL1839127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="105"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="909" mass="98862" checksum="AD6CD60DA4D21F0E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3E0</accession>
    <name>A0ABR3V3E0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5759</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000493">
        <property type="protein sequence ID" value="KAL1835961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="137"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="269"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1835961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="396" mass="42856" checksum="5A64AD2EBC3A3963" modified="2025-10-08" version="1">MSNSGFTSPFGANLNPFGSARLDTSSAMQRVAEEDENDTVTSPTTPSFGQQQQSGGSTFRGPFGGGDGGSESHPPSVRSPVNSEGYPAKYNFARRTSVSAESLKPVGDSLDNWSPPVHPKTPEQLERLKKAISGNFLFSHLDDEQSAQVLGALVEKPIPTKGIKVITQGDAGDFFYVVEKGSFDVYVNPSGSLQPGPDGMGENVGRIEAGGSFGELALMYNAPRAATVISAEPNCTLWALDRVTFRRILMESTFARRRMYEGFLEEVPLLSSLTPYERSKIADALESQKFPAGHTIIREGDPGYEFYLLESGEAVAYRSGNDTPVKHYKKGDFFGELALLNDAPRAASVVSQTEVKVARLGKNAFQRLLGPVEGIMRRTRYVGVQPEPGAVEPMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3I6</accession>
    <name>A0ABR3V3I6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000424">
        <property type="protein sequence ID" value="KAL1836354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="438" mass="48334" checksum="84C3882E42CF6DAB" modified="2025-10-08" version="1">MPHKPTMDHSPNTSPRTQPIHQNPVPLALSDYIARAAPRSDTTIDDKTAAEIRKKLEALVAEPERAPVQDKPRSPLSPQQPDEKATPPPPNPEADWPPPPPPPPADWLAIRQQLLPRKNQGKKADWIRGWSHAVSMHGDSAYCACSETIENVHHTRRKSRSSDIAGNVRAIFQRTASPSSTSNKNGPKPPPEPEICPHCSRPSSPPPSPSAAASFGSEKAFSTRKLTKRLSDLFLRVKSLRPERSPSAPKPRRRRGRRRGTGDDGDDEDDDDDDEGPHTATWPDGNYQPPWAVANAGFSPASQLFITRWRTQRIHRRITEFALSRQVVGAWRRCGGTRNSGKYYGGFPGCGSETTIVVVIRAYRLVCGASAPGICEEHVEAEESHGLAAARDDNNDDDDSAQGLGTWKQPRREETRLRSCSHSRGHRLYGQIPCVIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3L3</accession>
    <name>A0ABR3V3L3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000425">
        <property type="protein sequence ID" value="KAL1836347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31340" checksum="052606C303AE6C45" modified="2025-10-08" version="1">MEEVLLLGLKDKQGYLSFWNDNISYALRGCIVLELAFRGRIAMQKTPSRRSFPLPDRILEVIDDTMTGEVLLDEALKMMKTSEKMSVASWIDLMSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVVDTGAKEEIRRRVRNVLTQRTVVLPSSQWLPENLEFRYLRTLAMVCAAYAANVLENALSTLGHEAREKAFNQTDELLADYSQWPFGRKAVMNDIGENLPQVIAEEVNKAADKELQLEVVAAVLCVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V427</accession>
    <name>A0ABR3V427_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000399">
        <property type="protein sequence ID" value="KAL1836532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="502"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="906"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1125"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1222"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="938"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="970"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1259" mass="136764" checksum="FB919BDD371A676D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V439</accession>
    <name>A0ABR3V439_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_5423</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000446">
        <property type="protein sequence ID" value="KAL1836216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="121"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="14">
        <location>
            <begin position="429"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="15">
        <location>
            <begin position="533"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1836216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="638" mass="73072" checksum="DA82E8C9B7393457" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4G2</accession>
    <name>A0ABR3V4G2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000387">
        <property type="protein sequence ID" value="KAL1836630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="334" mass="37317" checksum="8F265C50F97FBF80" modified="2025-10-08" version="1">MPDLDLLTYARDAGSRGDDLYALLGADATANEADIRRAFRRRALTAHPDKAGDAYDPALYERIERARDVLLDSEARAAYTEAMRAVLLKKEERERMSAKRRRLVEELERREREAEEERGKRMKMNMGQEVVDAERAALAARGRAKMEEMRRMREEAERREREGSREKAATMRATSVGGEGEDGVNEPTTTTTTTTTTREGEKDGGDDYDERIAELERRLREKQQRKAEKEQRKAEKKAKKEAGDGQGRQQHPPPSQPPSSHPTAVESQADENKASSVPSFSSNKPADAANCASQPGNRFASTMARLRAAQAKKEEEKRRKAEEAARAAAGVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4J7</accession>
    <name>A0ABR3V4J7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000379">
        <property type="protein sequence ID" value="KAL1836679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="191" mass="20311" checksum="5D20467A366AAE27" modified="2025-10-08" version="1">MRTKPGRDGRSREKEMEGPWPIRATNRLLWLPGGSTGPNGRPGGIASTVAERSRPRTRPIGLRESPPSYVVSSLPLLSSPLFPSQALAATHQARVPDPTFTSLSCPPSTAPDAAYPPGELDVLLHNRDTLGVDGAQVGVFKEVDEEGLGGLLEGQNGLRLPPQLLGGGLELESDFSDLKEADLLALVCSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Q0</accession>
    <name>A0ABR3V4Q0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000378">
        <property type="protein sequence ID" value="KAL1836691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="10">
        <location>
            <begin position="276"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="41245" checksum="DE50B5DB6FC93D2A" modified="2025-10-08" version="1">MSGLPPVYIASVARTPVGSFLGSLSSLSATQLGSHAIKSAVERVPQIKPEDVEEVFFGNVLSANLGQAPARQCAIGAGLSEKVVCTTINKVCASGLKAIILGAQTIMTGNASIVVAGGTESMSNTPHYLPNLRTGTKYGDSTLVDGVQKDGLRDAYGKQELMGMQGELCSQEHGLTREMQDEYAIGTYKRAQAATEAGLFTEIAPIEVSGGRGKPPVTIDRDEEVKNLNEAKLKTVRPVFIPNGGTVTAANAAPINDGAAAVVLVSEAKLKELGIKPIAKILGWGDAARDPARFTIAPALAIPKAIQHAGLTPADVDYYEINEAFSVVALANIKLLGLDPEKVNVFGGSVAIGHPLGASGARIVTTLTSVLREKKGKIGVAGICNGGGGASALVIENLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4W3</accession>
    <name>A0ABR3V4W3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000364">
        <property type="protein sequence ID" value="KAL1836802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="57"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="357"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="494" mass="56563" checksum="08A587E15F79858A" modified="2025-10-08" version="1">MIERWNSGRKDRDRDRDQNRDRDITAPRYDSSNRISKPSRHPPPSRSTAATANRYLTQDEQSEQFVADEDKFVLRQAKKKADIRVREHRAKPIDYLAFGLRFIDPDRDSFDDDDADVEIPLPSPETVIQGLDEAQLKELEEDIRSYHTLETNERNKEYWSALLTLCSDRRQKLKPQGSEGRAVTSVASDVDRILGPKSLEQLEQLEKQIRLKLQSDEPVDTDYWGDLLKSLLIYKAKARLKKVCAAIKEARVQLLRARDPEKAKTLELADGDGDAILDSSSGALVPSKSAARSSTPTDAASSSAPPPGTARFAPAGNEDFSQATKALYDREVARGVGEGEEIFTAEVAVPGIQRPLWADKYRPRKPRYFNRVLMGYEWNKYNQTHYDHDNPPPKVVQGYRFNIFYPDLIDKTKAPTYKIIRENGRRKGESTAPAGKEDTCLIRFIAGPPYEDIAFRIVDREWDYSAKRERGFKSTFDKGILQLHFQFKKIFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V561</accession>
    <name>A0ABR3V561_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VTJ49DRAFT_4589</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000358">
        <property type="protein sequence ID" value="KAL1836856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="762"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="52"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="755"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL1836856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="951" mass="103686" checksum="1FC97323F6376F8C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5A4</accession>
    <name>A0ABR3V5A4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="JAZGSY010000347">
        <property type="protein sequence ID" value="KAL1836938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="201" mass="20915" checksum="D7BD03AB0DBA6356" modified="2025-10-08" version="1">MVHHKGPAPQLHDGSNLRIGIVHARWNDTIIEPLLAGAKAKLRECGVKESNIVVQTVPGSWELPIAVQRLYAASQVQSSSSGAGATAGDLLGSSTADLLSPTSSSSASTGPFDAIIAIGVLIKGETMHFEYIAGAVSEGLMRVSLDTGVPVIFGVLTVLTEDQAKARAGIIEGSHNHGEDWGLAAVEMGVKRKAWANGTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5E4</accession>
    <name>A0ABR3V5E4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Vacuole membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000342">
        <property type="protein sequence ID" value="KAL1836985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1836985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="146" mass="15144" checksum="A7677DF254953E5B" modified="2025-10-08" version="1">MGVLRPDLIVKNIVPVIMAGIIGIYGLVVSVLISDGLTQDGYALYTGFIQLGAGLAVGLAGMAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGMWKLDEQDISRHPISRICANLAASGLYGLIVALLMNSKATLNISCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5P9</accession>
    <name>A0ABR3V5P9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000330">
        <property type="protein sequence ID" value="KAL1837094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="83" mass="8848" checksum="23E2709317DB7E7A" modified="2025-10-08" version="1">MEALAKSPLPSPAVYQDMASEQIVISSWPTLGVGVSAVFGSLCCIAAIFVVIALASRVRKALKAVNLALQLLNIPVTRNPRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5U7</accession>
    <name>A0ABR3V5U7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">High affinity methionine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000327">
        <property type="protein sequence ID" value="KAL1837120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="54855" checksum="9C5E3FBA769AE6DD" modified="2025-10-08" version="1">MRRSGGRRGSGKAQDDSDAASQTSEEMGTSYLLPEQQKIGITGAVFLILNKMIGTGIFSTPSSIFAATGSVGITLLMWTVAGLLTLSGLGVYLEFGLAIPKSGGEKNYLERIFRRPRYLATSVFAVQMVLLGFSAGNSLAFGRYVLLALGHPMPDGWIPRLIAVACITFVVALHAALPRWGLRLTNALGIFKVLVLLLIVFSGFAALAGHRLVPDPRNFDNFWAIERGDGYGGGGAYAYATALLQVVYSYKGWENANYVMAELKNPQRTLKIAAPLAVVGVTALYVLANVAYFAAIPKGELARSEVIVAGLFFKNVFGESAAARSLPAFVALSNIGNVLAVSFAHSRVNQELAAEGVLPWSGFWASNMPFGTPAASLLLHWIVTVIVLIAPPPGPAYNFIVNLYTYPGAWINTFVAGGLIYLRLRASERWWSPWQTHLTVPVVFLCLNIFLAVTPFVPPAADDWAADGYPYWLFPTVASARALLDVYVVSMMSRPFSTLACRRIGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V612</accession>
    <name>A0ABR3V612_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000318">
        <property type="protein sequence ID" value="KAL1837204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047287575" description="cellulase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="411" mass="45069" checksum="064D22A22D0704B7" modified="2025-10-08" version="1">MKSSVLASLFVTGVVAQGGAWQQCGGMNFSGATTCVSGYTCVYVNDWYSQCQPGAAQPTTLRTSTTTSAPAPTSTTPAKGKFRWFGINQSCAEFGKDTYPGLWGKHFTFPSTSSIRTHINDGFNMFRVAFSMERLAPDRLTNSFDAGYLRNLTETVNFITSNGAYAVLDPHNFGRYYGNIITDRAAFGSFFSKFGAHFASNSRVVFDTNNEYHDMDQQLVFDLNQAAIDAIRAAGATSQYILVEGNSWTGAWTWNTTNTNLGGLRDPENKLVFQMHQYLDSDGSGTHEACVSTQVGVQRVIGATRWLKENGKLGLLGEFAGGANSVCRQAIEGMLNHLQENSDVWTGALWWAGGPWWGDYMYSFEPPSGTGYTYYNSLLKGFCHAPSLGTRNLAAYVMAFGAYSGRPRWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6B9</accession>
    <name>A0ABR3V6B9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1837160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="28"/>
        </location>
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            <end position="731"/>
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            <end position="380"/>
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        <location>
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            <begin position="359"/>
            <end position="377"/>
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    </feature>
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        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
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            <begin position="693"/>
            <end position="715"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1837160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="731" mass="79219" checksum="29CBED49C7F2A19A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6L5</accession>
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    </gene>
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000300">
        <property type="protein sequence ID" value="KAL1837380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Rrn9_dom"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10680">
        <property type="entry name" value="RRN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="637"/>
            <end position="665"/>
        </location>
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            <begin position="1"/>
            <end position="48"/>
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            <begin position="358"/>
            <end position="372"/>
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            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="724" mass="80122" checksum="64E2E1A670CC31D1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6M0</accession>
    <name>A0ABR3V6M0_HUMIN</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_3801</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Dikarya</taxon>
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    <reference evidence="2 3" key="1">
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            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF09447">
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="187" mass="21175" checksum="BBAC3CECE9380DCC" modified="2025-10-08" version="1">MPPTEHEILTNYLLVAAQLPSIVSLQEFITLFPRALQSSPRIRSLYRDLQSQRNAVVDAVAESIDEEARQGRAMRRAVIQARRRDADRLEERDEEVEIERILGNWSDAQRNNKHSLESILPEMESAVGELEAELQLLQEEEAALLASVQQTVGAMSDLRYGRLANSQLPEQVLDGLTNLEEICRAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6T5</accession>
    <name>A0ABR3V6T5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Clum A."/>
                <person name="Reid I.D."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000289">
        <property type="protein sequence ID" value="KAL1837489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF7071"/>
    </dbReference>
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        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR BYE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23257">
        <property type="entry name" value="DUF7071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
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    </dbReference>
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            <begin position="275"/>
            <end position="399"/>
        </location>
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            <end position="104"/>
        </location>
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            <begin position="185"/>
            <end position="266"/>
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            <begin position="412"/>
            <end position="512"/>
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        <location>
            <begin position="694"/>
            <end position="763"/>
        </location>
    </feature>
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            <begin position="824"/>
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            <begin position="1"/>
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            <end position="33"/>
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            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAL1837489.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="921" mass="101020" checksum="74EF8388E3C42B1C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6V9</accession>
    <name>A0ABR3V6V9_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">Mucin</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_3727</name>
    </gene>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000285">
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    </dbReference>
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        <property type="entry name" value="RPN13_DEUBAD_sf"/>
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        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V793</accession>
    <name>A0ABR3V793_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000276">
        <property type="protein sequence ID" value="KAL1837634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="88010" checksum="78EEB73EE64387C1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7X4</accession>
    <name>A0ABR3V7X4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000257">
        <property type="protein sequence ID" value="KAL1837859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="2">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="79" mass="8915" checksum="CD52F2DC8E872C59" modified="2025-10-08" version="1">MASSEDRSSSVDETPISPSRPNPARKNSLEFHLSHRPNRQELIDKTLLKEGVLHEDPRSPEDKYLEAIEAEYAKREGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V842</accession>
    <name>A0ABR3V842_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000246">
        <property type="protein sequence ID" value="KAL1837989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF92">
        <property type="entry name" value="OXYSTEROL BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46710" checksum="4240EC3BA11373DD" modified="2025-10-08" version="1">MDSKTLSSRLRELVQFLSTVKGDLANVTGPPSLLAPCSVVEVGRCWAERPHLFSAPALEPRADRRALLVLRWFLASLRSQLYVGVDHAAHAAAAGKKKGKGTGPGVSIRKPLNAFLGELFLASWTTEEEPCKARTELVAEQVSHHPPITAMHICAKEHDVRADGYARVEMTFRASSGVLIRQVGHATLRVGRFEEEWLIPLPEVRVRGFLAGCLYPEIAGTYHIVGSSGWAVEMQFWGEGLVRGTRNSLSARVYASREDMKKKQNAVYEVSGQWNVGWTVRECATGEVVEVYEVDAPENEPVAMETEPVEMQDSWETRRAWAGVLRGMAAGDMATVVAEKTQIEEAQRRMRANEAAKGVVWEPLFFRSCAGEEHAVFHKLVTGLDWPLHHERTKGVWRVNEERVRKVQRPFRGDLTPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V873</accession>
    <name>A0ABR3V873_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000244">
        <property type="protein sequence ID" value="KAL1838014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="175" mass="19344" checksum="6FBD07BFC19466FD" modified="2025-10-08" version="1">MEIWIWIGCNKLLRARPSTAKGPPSLPLEPRKPKLDRLVINLNYTDYVPDPTFPPPARLRLQADRQTRRGPQPILSSCRPQHASHEFHSPEPSPPVSTFASQTAGVGLANRRAHGSFPGTECHGVRCWALATGKSGFPRGVEAHRHPLLPSKARRMTRSHLRETTQSIPGKAGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V964</accession>
    <name>A0ABR3V964_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000218">
        <property type="protein sequence ID" value="KAL1838379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58405" checksum="73406AFEF5D237F4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9B1</accession>
    <name>A0ABR3V9B1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000230">
        <property type="protein sequence ID" value="KAL1838210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="507" mass="53328" checksum="CA561BD80024CF9D" modified="2025-10-08" version="1">MPRTEGVSMVTVGFVTVEVYLSPTSIEGGFAYDTETDGEECPPTTLYRQMRKAFRDEVVSRMERFVEWVLERGEGIVNRTVGLLGLGLSGAGATEMGLEMEIDKHREGGGQQKLLEGMRGGVTLASDLSCECWCHGSPAQDHHTPNRDLKDHSRKHQDEHHVHHSTTASSSQDANPPMAATTPTTTTSSTTNLEPKPIPRPQPLLASNPESDPSPDPVPLLSYIPDPLDIISRIVALMANGLYGGIMCLLVIAIVEKIMLAIAAARAGREAQAPRPRRRAGSRAGGGGRGPRLRGGSLAGEGVGVGDAPEGVGGRPVGVDGSRLGAGPGFGYEDWSGYDGSEAGYGGGEGKGDGDERALEAAWEDAACRAEQETHELGEHVATEGWMVAGSEVTLRLRGGDANIAGAAAAAAAAAAGVSAYPRHIGGIGLGARRWDHGVRHPGSLGRAELRLGRTRFLLEVAVISLVVTGLMKVLTVAVPGWYMCVVELVAGMMGLELYAPGERAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9D2</accession>
    <name>A0ABR3V9D2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="197" mass="22162" checksum="71DAC418EC0DC513" modified="2025-10-08" version="1">MLSRLAQRRASAPKKGDGPLLERRPDRELPSLNQIRPPWRRTLPIFALTIAIASLAIFNYQKLSSPVVSATLYALRTSPRARAALGDEIYFARRIPWISGELNQLHGRIDVRFRVKGTKGEGTMRFASVRPSPRGTFETTEWSLEMDGGDVIDLLEEGDPFRAMTGADGFGTVGYEEDDEEEERAVARTRGFRQRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9M7</accession>
    <name>A0ABR3V9M7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000215">
        <property type="protein sequence ID" value="KAL1838429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="559" mass="64096" checksum="B1BA7C163229AA4A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9U3</accession>
    <name>A0ABR3V9U3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000204">
        <property type="protein sequence ID" value="KAL1838604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAL1838604.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="945" mass="100554" checksum="EDCDE75CF42FAD12" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAH6</accession>
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        </submittedName>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="263" mass="28489" checksum="4FC4283C35AC8291" modified="2025-10-08" version="1">MDRLKDSVNASWQHTKRTGHRAVQAAVSGARETLSSRPGAARASIDEGWEDEDGWELVDDDNVSSPGQCPTNHRRISEPVLFEQVPVVGGGGNTFSDDMQLKPKARAASDPATARPLLPSSTSAVTTAAATSTTSKPLTPAEPPPFTHIPMRARRLVIPSTAPTSSSSSSAPPMPPTPGVSDNPYGQLNEQPVDDEEEPMRYHRAGRRLKDRIAAVKRAHRGAELLQREQHRGDNTKNDKEGDEENEGREAEYHPIKGQESPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAM2</accession>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Nguyen T.T.M."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="SANT"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="667"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="808" mass="87911" checksum="9AFB23E111B3448A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBE6</accession>
    <name>A0ABR3VBE6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_1932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000179">
        <property type="protein sequence ID" value="KAL1839032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="47"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="755" mass="81818" checksum="87E055A1650D2F1C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBU4</accession>
    <name>A0ABR3VBU4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000182">
        <property type="protein sequence ID" value="KAL1838967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="411" mass="46429" checksum="20A5A7045E47265F" modified="2025-10-08" version="1">METILRRVRMAERQVARRMKRQEDLKFREAKHERMIDIAHMRRQIGENINAAIKARHEDLKLGPLAPRRDGVKFDRVMSFWGSISVERVMLSTKLTDEQRNARAAWCGGTENFCLAVGDRVVVLEGPYKGKIAPIESINKENMTLELGGNVGLVNATMPEFMQDDDQDPVQVTKGVVPISAVRMVHPITDRATGVTRDVIIRELKPVDFRLDDRNYRKYFARMVPGLNVRIPWPKPAKVEPEEYAVDTLRIDVEERTFVPTLLRPPMPECIIDELRNKYSKFRTRHTPEYIEEIKRREAEKRAKKTGPPGAKASMLLPVQELNIKIKEERRQRGQPELTEEMLAKIGEVIARNKLGKVAVAPSPVSTTPAKGGAKAKKDAEVAKVQKAVEQLAIGGDAQQPPKGGDQPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBW5</accession>
    <name>A0ABR3VBW5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_1736</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000169">
        <property type="protein sequence ID" value="KAL1839218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045517022" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="240"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1839218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="301" mass="31778" checksum="82E49E7E50D8C547" modified="2025-10-08" version="1">MFFKAATLALACATSVSAHTLMHGVAVNGVDQGDGRGVYIRTPPNNSPVKDLASPDLVCNVNGGRAVSGFVQAAAGDTLTFEWFHNTRGDDIIDRSHSGPIITYIAPFTEGNGAQSIWTKIHEDGFDASTRQWAVDKLIDNGGKIDFVLPAALAPGKYLIRQEIIAHHESDAAFNVNPARGAQFYPSCVQIEVSGTGTAVPDQNFNFNTGYTYSDPGIVFNLYANFNSYQIPGPEVWTAAGSGNGNGNGNGNGNDTPAPPTTTATPTPTATAAPVTTTTSPSPARPTRCPGRRLKREEPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC04</accession>
    <name>A0ABR3VC04_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000186">
        <property type="protein sequence ID" value="KAL1838906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="502"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="932" mass="105931" checksum="33C6943A55F35AA4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCC6</accession>
    <name>A0ABR3VCC6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000191">
        <property type="protein sequence ID" value="KAL1838833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="215" mass="22903" checksum="2272DB1ECAAD5FE7" modified="2025-10-08" version="1">MPPRKNPKQGTPEKPSDAKAYVDAIFTPREQVVLIHCLLTIKGFGQDLATSIDLQKVAERLELQNHRSVSNAWCAIKKKFAEHEAKVRAESGETGEPATATTNNGENKAEKQEVDDNPSPTKRPRTMRKASTATNGDPATPKKPRAPRGKKAAAAQASVPTTPATPAGGDQVNDQATETSADDADDVKKEIKQEPDVQTEGEAGEVTNGADAGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCG5</accession>
    <name>A0ABR3VCG5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MET3</name>
        <name evidence="11" type="ORF">VTJ49DRAFT_2102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000188">
        <property type="protein sequence ID" value="KAL1838878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="8">
        <location>
            <begin position="395"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="7">
        <location>
            <begin position="395"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="7">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="573" mass="64031" checksum="3B4B336CD45F00AE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCL4</accession>
    <name>A0ABR3VCL4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peroxisomal adenine nucleotide transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_1857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000174">
        <property type="protein sequence ID" value="KAL1839126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36469" checksum="E90D6FB22775C27D" modified="2025-10-08" version="1">MAVQSKPAPIGPWGKATAGAAGAVLANALVYPLDLIKTKLQVQVTPSQPADGETKPDEETHYKSTWDAVTKIASAEGVSGLYAGMSGALLGVASTNFAYFYWYSAVRNAYDKYRGAGHKSSTFEELALGAVAGALAQLFTIPVAVITTRQQTQTKADRKGFFETGREVVNGEDGICGLWRGLKASLVLVVNPSITYGAYERLKTILFPNKKNLSPWEAFALGAMSKALATIVTQPLIVAKVGLQSKPPPSRQGKPFKSFVEVMQFIIENEGPLSLFKGIGPQILKGLLVQGILMMTKERVELMFILFVRYLQVMRSKRIARAEAVVAAAKQIAPITTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCQ1</accession>
    <name>A0ABR3VCQ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="301"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="511" mass="55904" checksum="CEC5C719B6507B06" modified="2025-10-08" version="1">MGNQNSKDAGAASSKAVAGDDTLQSYPSFSKSDTRESSRSFRSLRSKIPGSSKTDSPRSSAMLIGVDATDKSDAASVKSGRNGKSPRPGIGRNDSYQSPTSPSSDIATSPTSPLAEEVPPPSPIQSASMKAGPPSGIPNPNLVGHQPGQSILVKREGTPNPVITTVQEVTKDDSTAGVAMSDIKDIDVDDFIKRLLDAAYSGKVTKSVCLKNAEITAICHRVREVFLSQPALLELDAPVKIVGDVHGQYTDLIRMFEMCGFPPHSNFLFLGDYVDRGKQSLETILLLFCYKLKYPENFFLLRGNHECANVTRVYGFYDECKRRCNVKVWKTFVDTFNTLPIAAIVAAKIFCVHGGLSPALGHMDDIRNIARPTDVPDYGLLNDLLWSDPADMDQDWEANERGVSYCFGKKVITDFLAANDFDLVCRAHMVVEDGYEFFTDRVLVTVFSAPNYCGEFDNWGAVMSVSTELLCSFELLKPLDSNALKNHIKKGRNKRNQMLNSPPAGLYPQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCY5</accession>
    <name>A0ABR3VCY5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide transporter PTR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000143">
        <property type="protein sequence ID" value="KAL1839723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="64259" checksum="B9C4572D56D17112" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE08</accession>
    <name>A0ABR3VE08_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="255" mass="29060" checksum="A241A5356A1F6E3E" modified="2025-10-08" version="1">MARTYRILRRPWPAKAPLYWGLIPELAGVVPVLILFGVQHPDAFRTLFWRIGFENKLNSNPNMILYAYANYQPLPPIPFVWSYTLTMYNVAISIVSLFILIAKMIAIIMKVYFPVIGTFVGIAQTALYAVSVYGQAGPDYADERYPSPSPWYLRHGCDLAKPYGALKSCQMAQGTFAVTVYMLALYLAQTCFAIWAMMPNKALDKEDTDSDDEERNSPIQKDKGVEVELQQVPFTPRTQAFHALERKLPLRDTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE57</accession>
    <name>A0ABR3VE57_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="4">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000129">
        <property type="protein sequence ID" value="KAL1840051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="59"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="173" mass="18247" checksum="AED4731A9A30ED71" modified="2025-10-08" version="1">MASITRCLRVARPAVFTAVARASASRSVAARAFSVSAANALRKYTKEHEWIDLSADKKTGVVGISEYAAKQLGDIVYVELPEEGKEVSAGDAIGAVESVKSAADINSPISCKITQVNLVLEEKPGTINQVAEDDSHGGGWIAKVQVTEQGLKDLEGLMDPDAYAAFTAEAGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE72</accession>
    <name>A0ABR3VE72_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cholesterol oxidase</fullName>
            <ecNumber evidence="13">1.1.3.6</ecNumber>
            <ecNumber evidence="11">5.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholesterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_842</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid metabolism; cholesterol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="13"/>
    <dbReference type="EC" id="5.3.3.1" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000129">
        <property type="protein sequence ID" value="KAL1840066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052542">
        <property type="entry name" value="Cholesterol_Oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470">
        <property type="entry name" value="CHOLESTEROL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470:SF1">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Rhodanese" evidence="17">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1840066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1378" mass="151550" checksum="2483DDDF3E12965B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEM6</accession>
    <name>A0ABR3VEM6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000123">
        <property type="protein sequence ID" value="KAL1840199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118240" checksum="7761F42C5AA80717" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VER5</accession>
    <name>A0ABR3VER5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="113" mass="12236" checksum="65530C67B56DA7AD" modified="2025-10-08" version="1">MASALTKYKLVFNVPPAALEACKAAIFAAGAGRYPGAGNYTECCFTVFGKGQFRPGDAANPHIGKVGELEYVEEARVETLCVGEDVARKAVEALKKAHPYEEPAYEVYKIEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEU0</accession>
    <name>A0ABR3VEU0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF10">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="520" mass="58513" checksum="222F5E183691C11E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF58</accession>
    <name>A0ABR3VF58_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000110">
        <property type="protein sequence ID" value="KAL1840495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="450" mass="49570" checksum="F8423076E69FFE74" modified="2025-10-08" version="1">MTADGPAAHVSADAGADVGTQEPGLSHILNSGSHTNTPGDSPTPNGDDRLTLIITTSPTPSAPSTELLEQIIAAFRTHCPDLTRCRVILVLDTYDHVSSTNRLKKGHVTADSARLYAEYKVRAKRLILDVYAGPDVEDEELVKDSAKAEFGCLGILPQHANNAVSLAITRTPDRRVTFVEPAQRLGFGLAVRSALRLTETPYVWVQQHDWALITDIPLGPLLTLMQQHSGPAAAAAAAANTDGEEDDDNNNDDMDAVVDDSSPRTTRVPIKYVCFPSVRMVEYARSDHVMRYTALRALTNLHKQNFSVRVDVPSANVDAAGETSTTKIPLTPLFFWHDKPHVAETAHYLARVFPGRASLPRGAFIEDTIGHRARTEMKDGHWRRWACWLYYPDEGKQLCVRHLKGRTWRGTAAELAKKMEFMRLNEGRPRRRAGEKMAVAGDGTVVADTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF97</accession>
    <name>A0ABR3VF97_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GRF-like zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000114">
        <property type="protein sequence ID" value="KAL1840426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056444">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23549">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRF-like zinc ribbon" evidence="2">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="392" mass="43403" checksum="BC145E875056B42C" modified="2025-10-08" version="1">MAPTPDSEPTSNVPHQTSKDEVPRGLPTLRSHELLVFDDSEDDEPPASQKAQPTVSSAVAGGRILILDDSEDDEPPASQKAQPTVSSVVAGGRILILDDSEDDEPSTSPQSQRKGENNHIDKDKRDDEASCSSRAQPSDEDDATSVSEFEPATPGSTQDTPEHADEIDDLASSFSKVTVTGPSAQKEEMWVHETSYRNANGNAGRPYYKCLYCPYNEHEEEYNFLVFRDQRGNLASNPPCECGASAKTLVDSPRKGRRVHLPAPPRFEYFLLLPVEIRIMIYDSVLRAPIPSGGTTPEVRFFEKKNLALLRVNKLVGAEAARHFYSVNTFCLSSDMLDNLWLEVSSVDRWGAFWLFRQLGSNAVFVRSISKSPIYPLIHSQPLSSLLILRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFD1</accession>
    <name>A0ABR3VFD1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000107">
        <property type="protein sequence ID" value="KAL1840578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="1">
        <location>
            <begin position="38"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="239" mass="27269" checksum="2E7ACC3ABB84D3D5" modified="2025-10-08" version="1">MGQLLTRFYQRQNARALMELAPARNAGEQPPLPELDRTTLLQALTIVGNYIQQKNRQVTVIAVGGAVNTIFLQSRPSTHDVDFYNNSLSVADLRLVAEGARYAAQRIPQLNEEWFNNHTIFFIPHDLRSTLTQDALTQNAVIFHHGGLKLLAAPWNYAFCTKVHRLSNAGKARPYDLNDAVHYIHRYLQTHRISTVSLATVQEWFTTYRILWNAAVEQIIARVNATYRAQFHVNYNVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG72</accession>
    <name>A0ABR3VG72_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="114"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="342" mass="38445" checksum="BB323D95AD6AF9F3" modified="2025-10-08" version="1">MQPRSCPSSFEFAPVPAGIVADRVHFPTSEVPSFPMATDRRDSSEPIINPNPILDQYYRSFESRIGYRLVLGDTRHHGWYEKGTFWPFPVGKALRRMEEKLFQALNLPAGSQVLDAGCGMGHVAIYMARRGLRITGIDYMDIHVAKAKRNVARATDLPAGAVTVQRMDYHHLESIPSESHDGVYTMETFVHATDPEAVLAGFYRILRPGGRVALIEYDNALNPATASDGAPRKAVEDMELVNKWAAMPTNARADMGLYKRLLEEAGFVDVQIVDLSANIRPMLRLFYWLAIVPYFFVKLFHLERWFVNTVAGAQAYRNQDHWRYVQVTATKPGGTIEGAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG79</accession>
    <name>A0ABR3VG79_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anthranilate phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
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        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
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    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="104"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="45702" checksum="3B22E42CF746DB93" modified="2025-10-08" version="1">MSPETLPRIDLKPLLARLWPLGHPDPVTPEEIAQAISYFFTNQVSDVQAASLLMTLHFTTLDRNAEVLAKTAECMLKAAARIDEPALRAAVDGKRRREGSYEGGLVDIVGTGGDSHNTFNISTTASILASSLLLVAKHGNRASTSKSGSADLLTNMQPLAPQLDRVRPDTIVDLYRNTNYGFLFAPVFHPGMRHVAPVRKQLPWRTIFNLLGPLANPTDLGSASDATQPPLLEARMIGVARKDLGPVFTRALELAGARKALVVCGDEDLDEISCAGDTHCWRIRPADPSHPDSGATVTEHFRLHPRDFGLPAHPLSEVSPGKEPHENAAILRRILDGQVDDDDPILHFVLINAAALFVVSGVCDADTSDLGYGDDGKVITERGPGGGRWKEGVRRVRWAIKSGEAARQWAKFVEVTNSFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3VGV7_HUMIN</name>
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        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1840528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="88"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="132"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
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        </location>
    </feature>
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        <location>
            <begin position="698"/>
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        </location>
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            <begin position="949"/>
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        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="969" mass="105452" checksum="3C6B4C676212B255" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGY8</accession>
    <name>A0ABR3VGY8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="73"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="602"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="927" mass="97460" checksum="4557D8506EC15F44" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHN5</accession>
    <name>A0ABR3VHN5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="295" mass="33713" checksum="A8C1DBC9D1491D95" modified="2025-10-08" version="1">MCDILWADPLEDFGQEKTTDYFVHNHVRGCSYFFSYPAACHFLEKNNLLSIIRAHEAQDAGYRMYRKTRTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILSTCSEEELREDSANSPGPMSPALPSASSIGSQDPESIEYKRRAIKNKILAIGRLSRVFQVLREESERVTELKTVSGGRLPAGTLMLGAEGIKNAIHNFEDARKVDLQNERLPPSHEEVQKQQEEERQQALERAAREAEQDKKLQTLSRRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI08</accession>
    <name>A0ABR3VI08_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF13">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="427" mass="48490" checksum="CB3C43C1E42E2119" modified="2025-10-08" version="1">MPETTVYELHPLGWENDPEEEKLKLSMLDYFSAQLYDAYALFFKLPDGEQSHTLAILKEGLERTLAQCRHMMGTIEQDDDTHDCFFLKKRDSTVKFVVKYFGPEDGVPSMVEIEKTHYASGVLDVTKLSVEGLLTTEMPEYHPSRKPVAAAFQANFIPGGLIFVTSQHHYTNDLTGWANFARQTRRQLRACVLLHLPLSKAAELKPLATPKDPDAMPKWISTYNAMCALLWRILARHRIPLYNCDPDVEIPLAVETVNMRLRADPPLPARQQRNIFWVAASSAHPNPLTAREVAAQESQVPLSRLAVKIRTMTNGVDQETVLQFLAMTAPVRDKTRLFTRVNSFPPLSFLMTDWRDADLYHTDFGFGRPCAFRHFFGTSKSMKGISLIVVYPPRTSDNPDEGFEFLVAVENDILDAFLVDPDLTSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIA4</accession>
    <name>A0ABR3VIA4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="407" mass="44312" checksum="03A5B4987F600F6D" modified="2025-10-08" version="1">MVVYVPLAGNPRGVTIIAVLWSMAVFSAIFVALRLYSKITRTRHVWWDDHFIVAAWILLLVSCSTTTANARLGFGLHTYEVPFENIVPFGIQSNVSGFTSILAVACSKTSFAITLLRLSDGWMKWFIIVLVILLNLTHYTSSIFFWVSCNPPAKTWNPLLEGECWPISVTVNYSLFVGGTLSAFSDFALALLPWRLLLRFNMYNREKIGVAICMSMGIFAGITCIVKMTTIPLLYDGDFSYNSLPLVLWGFMEPSLTIVAASIPVLRHLFRSFRRDHDSTLPPMSRSDDPTSSHAGAGARARARAAAAGATADAGNNSASDEKQQGENVVEKAARGNYQLQRQQLEAAVAAEKGTATAGTETTGTGTTLTATSSPRGQPSSPVMRHQADNDNRSESSTLTNKGGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIZ0</accession>
    <name>A0ABR3VIZ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="622" mass="69015" checksum="8D06EAFA2C22158D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJE9</accession>
    <name>A0ABR3VJE9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31746" checksum="4F9CA87C6C3766CA" modified="2025-10-08" version="1">MSTASTTTFQHPEYHTPITLPPGLSQEQLLTFQPFTSWLSTLQTSLTLQHHQPSHPFHTSPYTLHSITVQSYDLFGSSRLGFVKLTSHISTAQGETLPGAVFLRGPSVAVLVLLVPDDVAPGSAQEEDERMAVLTVQPRIAAGSLGFAELPAGMVDGETGNFAGQAAREMQEELGVEIKEEELVCLSELVGDDGSPGGSKDGEGDGNVPLPRGVYPSPGACDEYIPIYLHERRVPRAQLAEWEGRLTGLRDHGERITLKLVKMKDLWREGARDAKCLAAVALWEGLRREGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJG9</accession>
    <name>A0ABR3VJG9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear protein Es2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51221" checksum="ACD5952FDF7EAE9B" modified="2025-10-08" version="1">MDATTQSTALVRKRTDTELMPPPPPAKRIQRPKHVLDEDSYTEALSHIIARDFFPGLLETEIQQEYLDALESKDEEWIDSASRRLQHVMTPGHRRGLAARLRSTAPGATPLNYAGDTPASVASAVTATTSQKPPAVDTSLSLAAFQAKYTSEDNESFYKLLDKQNQKRVEKYAWLWTGNKLPSKQQLKQKEVETKLLAQRGLDALRDDGFSKDRLAIRDKDAEDRPAVPDRGPWKPNNELMFVPDGIEGRMETVAERAQAESRAGPKKIVYENTGVPQPVPKEAPADGRSRASSPTLSEIRNAIAGHRRPCDVESTTAGFGGETPRVNGYAFVDDEEPEPSPAPREKEKPPTINLGPGDATPNPFKLAEPRKREVLHHRMVERISQSKRTSARLGVTGKIERTPVPRFPSSPRVSGPGLTPAAQRLWSKIGGGDRRVVNSPFSDSVKFTPRVTPRKGSGLKSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJR9</accession>
    <name>A0ABR3VJR9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000053">
        <property type="protein sequence ID" value="KAL1842129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="210" mass="23344" checksum="3D4FF863C0726504" modified="2025-10-08" version="1">MAQAGTGGSYNNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNMYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDISNAKSFQNTRKWIDDVRAERGNDVIIVLVGNKTDLNDKREVTTQQGEEEAQRNGLMFVETSAKLGHNVKTLFKRIAQALPGMEGTDAAAQASSQMIDVKTPPTPAPQEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJT3</accession>
    <name>A0ABR3VJT3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="10">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6271</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="211"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="265"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="894"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1582" mass="178080" checksum="8BAED29943A32F96" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKH1</accession>
    <name>A0ABR3VKH1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="142"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="481" mass="52196" checksum="B6C9B90FFA606096" modified="2025-10-08" version="1">MARRSSRSAAQPKSTTVETQVDVTVSKTKKQVNGTETTAVTKSTTTEVKTGISKRKSAHAEPTTKREPEEPAEAAASDDEDQDDSQRSAKKRKITKTTKNRPAEDDAAMTLAPRTAISSLKHAMYIGAHVSAAGGVHNAVTNALKIGGNAFALFLKSQRKWASPPLADDARTQFHALSKQHNYDAGRHVLPHGSYLVNLAQADREKADQAYNSFLDDLQRCAALGIKLYNFHPGSTGAGGDMAGACSRIAANLNRAHRATAGSNVVTLLENMCGSGNVVGGRFEDLRDIIAQVEDKSRVGVCLDTCHAFAAGYDLRSPEAWAATMKEFDSVIGLGYLRALHINDSKAPFASHRDLHANIGTGFLGLRAFHNLVNDPRLAGLPMVLETPIEEKGPDGKTVNNPQIWADEIKLLESLIEMDPESDEFREKEKELQARGAAERKRVQEQVDRKAAKDAKKAAKGKTKRRKKGDEDSCDSCNESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLW7</accession>
    <name>A0ABR3VLW7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Suppressor of anucleate metulae protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4462</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="571"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="621" mass="68858" checksum="8D49E1C8B4C65996" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM25</accession>
    <name>A0ABR3VM25_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046226361" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="204" mass="23445" checksum="A0BCEC61FD431254" modified="2025-10-08" version="1">MFLQTAARLLLAASVLLGSAAAHNIQLPAHGRECFHENLHRGDKMTVTFQVGDREFGGAGNLEIDFWITNPIGQFEVNDKSVSNGDFSFDAKHDGKYVYCFGNEHWGATSKEVSFNVHGIVYVSEADAPQDPLEVEVRKLSEMLERVKDEQSYIVLRERTHRNTAESTNSRVKWWNLFVICFVIGDFIFQVWWLRRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM68</accession>
    <name>A0ABR3VM68_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine carbamoyltransferase, mitochondrial</fullName>
            <ecNumber evidence="2">2.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ornithine transcarbamylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="9">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="8">
        <location>
            <begin position="187"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="353" mass="37663" checksum="F062B890F10A46DD" modified="2025-10-08" version="1">MRSLATSAAPAGSSSAAKPRHLLSISDLSAAEFAKLVRNASAHKTAVKAAFAAGEQPPKPLHGSLTGRTVAMMFSKRSTRTRVSTEAAVQLMGGHPMFLGKDDIQLGVNESLYDTSVVVSSMTSCMVARVGAHSEVADLAAHSSVPVINALSNDFHPLQTIADFQTIHETFSSPNSTPSSESSLGLEGLKVAWVGDSNNVLFDLAIGCVKMGVDIAVASPEGYGIPERMRQLILAAGEGVAKPGKLFETRVPEEAVRDADILVTDTWVSMGQEAESQKRLKAFAGFQITNALAERGGAKPHWKFMHCLPRHPEEVDDEVFYGPRSLVFPEAENRLWAAVAALEAFVVNKGKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMC0</accession>
    <name>A0ABR3VMC0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neuraminidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041079">
        <property type="entry name" value="Neuraminidase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18413">
        <property type="entry name" value="Neuraminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neuraminidase-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="976" mass="109579" checksum="DD042465C7CBC4BE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VME5</accession>
    <name>A0ABR3VME5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="94" mass="11058" checksum="1F1B6B5D01157A50" modified="2025-10-08" version="1">MVHLHLDLSLKHLRKRIHKAIVYITAFLFPPLAVYLRHRTRRNDFAVNVVLTLLGWYVSALTPLGWYVYTTGGWFYRLLRLLPGVLHALYLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMJ9</accession>
    <name>A0ABR3VMJ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1843005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="346" mass="35672" checksum="EEDBF00A7A32D26E" modified="2025-10-08" version="1">MADFQAPPGPPPPKVPEGWVVRWDENYKEWFYVNTYTKKSQWEKPTEPAQPDGGLPPRPPSQPPSYVASNTTGGSNNPFFPNPDTKPKVSDHPSLQASSSSPSSSSAKPNTLEEDERLARQLQAEEDARMAAALQGQSQQSAPPVPPHPYGSPSPQPQQQQQQQSQPFPAQLPPRPGERSGKSGGLLGKVLSAVSGKKGSSSSSGHGHSQGYGQGHGYVPPQYAAGGYAPVPGGGYGAHPPPPQGYYPPGPPHGQHPYGGGYYGPPHGHGYPGGVASGSHRKPGGGMGAMAGGAALGVGAGLVGGMLVADAISDAHQEAYQEGFQDGANFDDNGGDFGGGDFGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMP4</accession>
    <name>A0ABR3VMP4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannan polymerase II complex ANP1 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39956" checksum="5923D62DC9DC6D9A" modified="2025-10-08" version="1">MQRFYCWGPAKSPMQMSPNEQAEWTAHLPTPVIFNKHTPLEVNSSTIEFVDLNPIKSTTKALQNKERVLLLTPLKDASKYLSKYFELIVELTYPHDLIDLAFLVSDTTDDTIAVLSAELERIQKRTDGVAFRSATIIQKDFGFSLSQEVEDRHGFEAQAPRRKAMARARNYLLATALKPEHSWVYWRDADIVESPPKIIEDFIAHDRDILVPNVWFHRYENGKDIEGRFDYNSWIDSAQARKLAAKLDKDVIIVEGYKQFKTGRTYMALMGDWREDKDKEIELDGIGGVNIIVKADVHRSGINFPCYAFENQAETEGFAKMAKRAGYGVYGLPNYVVWHIDTQEKGGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMQ4</accession>
    <name>A0ABR3VMQ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="454" mass="48543" checksum="A01FC3A82925A886" modified="2025-10-08" version="1">MAITHLPVIPPSASEAAAVSGSGADPLPSNPTPAPVVAAPAPTPWHAGHQHSLSSASTATVDIEAWTVAALESLNITPVARGTGTALSIALDAEVAESSSSHVSAAPGGGLKLRGVKFGEGDGDDDGEAPGGRLRRTPSRRDSLRRRESLLMGKEGSRQRRRWENDHLAHVPNVVPPLPSDFQIHPTHPVLPPVPYQLAQYWDLGGLRERAEKRREEEKQRRLRGGSGKSKRKGHATTATATAAEASEEYKDDGRDGMQHQQQHVGRVPRDLRATVKRTPAAREWLRVLEQPVREFVVRCGLVASAENNGNMASSDSETDPDDEEIVFVGRNGAMRDGKPPRAGAAGGSGTSKARPGDVERKGAVLESGMVLEVEEGGGGAFQRWLTHSISDYYGLDSKSVTVGNPARRVVYVAVKQQKPPGKSSNSKHKQSSARHGGKPACRPVLPPPLWEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMS3</accession>
    <name>A0ABR3VMS3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Importin subunit beta-1/Transportin-1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="2">
        <location>
            <begin position="233"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="402" mass="46075" checksum="B9248136E002EC3A" modified="2025-10-08" version="1">MSAEQFPRFIDTLNQRIMNLIQSQETYDKMGGVYIIDALVDFEGVEPALKYTRFQQYISIILRGKDLTPMQPAAVVLGKLCKPGGSLISDLVDAEMHTALEWLQSDRVEERRYSAVLVLRELARNAPTLMYPYVGFVFDQIWIGLRDPRHRIRTTSSETVSACFKIIRERDQEMKQEWMDKMYNEAVKGLKTNTVEYIHASLLVLKELLEQGGMYMQDHYDEACDIVFRHKDARDPAIRKTVIFLIPDLANYAPTEFGEKYLHKFMVYLSGMLKKEKERNDAFLAIGNVANSVKSSIAPYLDGVLLYVREGLSVQSRKRGSVDPVFDCISRLAVAVGQTLSKYMEALLDPIFACELTPKLTQALVDMAFYIPPVKGTIQERLLNMLSKIPRIRLFTSEARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMU9</accession>
    <name>A0ABR3VMU9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="360" mass="41034" checksum="71E1FD4968AF1B88" modified="2025-10-08" version="1">MSRPLRIPSPQTPLHLYRQLLREASYLPPIARPYIDKQIKTSFRKHQKHDAKDAQRIRQGKHDLRVLRAANSGDLMRMRRVLLRAFGRMGRRRRELMADLLNRPPPTNTEELAKFAANVSTITAGDRETDWLDAWDTEKLRALAKSQLAAGLINSPKPPITVSNIKPEKAVPAENSWGRPFHPKPARTKLKNAWKLVADKCMPPLPKEEWQALGDIVEGVVETRWLPPPRRALAHPLSPQEPMRRWDWEAYAVKPVAVVDRPANRRNKLLTGAVDDNTPTGDPQPINCHRYTPRLWRRLLGGIWQLTPVMEPQPGGKGWSITWGKPKFEPAKAIEGALEFFSSLPEPAEPPKGGRRRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN28</accession>
    <name>A0ABR3VN28_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047129201" evidence="2">
        <location>
            <begin position="28"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="563" mass="59407" checksum="DB8461DC9F9E6404" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN72</accession>
    <name>A0ABR3VN72_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_3348</name>
        <name evidence="15" type="ORF">VTJ49DRAFT_4841</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1842558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1843034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="357" mass="40518" checksum="28E491C36D54ADA3" modified="2025-10-08" version="1">MALNPRDLNKYRADARAGHTLLTPEERLKLIKPYLPPPPSRSRSRSPRVDVTSNSSSSRTRHDRPPRLGVRRFLLRLYHQLVFVIIHVVFSVYIRLRQAYHAVANRIYSVYYYHHRTPELIRRDVKGLRKLPKHLSVILTLDDQGRRSAGLERVINEVADVAAWCASAGIPHLSVYEKTGFLKEYLPETHFAVSQQLRSYFGRDRPSLSVRAPHMPAIESVRSSRNLHGSGGGSSSSGSSDEGDSSGFHLSVLLISAEDGRDSMVDLTKTLAEMSQRKKLKTDDISMELVDAELTESIMSEPDLLILFGPHVELSGYPPWQIRLTEIFHVRDNQGVGYQVFLRGLRQYAQAQMRKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNI7</accession>
    <name>A0ABR3VNI7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="443"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="523" mass="57370" checksum="D6BBB5298E7129FC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNJ7</accession>
    <name>A0ABR3VNJ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="273" mass="29862" checksum="AD8556AD40712894" modified="2025-10-08" version="1">MPAPTALLQPAPAPENVPLPAPQDDDDDLLVDMQEASTQANAAVPPQPAEDTTDMAIDEEGRPKFAPGKDIDPIRRSETRKIPIPPNRMSALKANWTKANVHSLPVSIHSTISRTYPPLVDHCKLQVRMNVKEKRVELRSSKHTASNEALQMGADFVSAFAMGFDIDDAIALLRLDSLYIQSFDIKDVRQTLGPDALSRAIGRIAGKDGKTKFAIENATKTRIVLAGSRVHILGAFENIGMARESIVSLVLGSQPGKVYNNLRIIASRLKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNL5</accession>
    <name>A0ABR3VNL5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_1380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="177"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1843509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="442" mass="50119" checksum="A129742087D9565D" modified="2025-10-08" version="1">MAGGTEPFPPLTSAADRMTADLNNNSNVARRRRKSSALGSELRVGDTGAPSLATGIAAAAPPTPTKRGSKRRKARSILRRAKSICVKHTWVLPLAILLVFLTGYALNPSESNPFHHFIFLSYRLPTTSPDEAPQYGKGPWDIAFVTFYTVVLSFTREFIMQEILRPMARWAGLRSRGKQARYMEQVYTAIYFGILGPTGMYVMSRTPVWYFNTRAMYEGFPHKTHDALFKFYYLFQAAYWAQQAIVLLLGMEKPRKDFRELVGHHIVSLALIGLSYRFHFTYMGLAVYITHDISDFFLATSKTLNYLDHWLTGPYYFTFMCVWIYLRHYLNLRILASLFTEFKTVGPYELDWANEQYKCTLSFVITLSLLSALQALNLFWLFFILRIAYRFAVHNVARDDRSEAEESELELEAEKANGGAALEGKANGSAAGVANGAAKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNR5</accession>
    <name>A0ABR3VNR5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="178" mass="19167" checksum="B7B74986025E043E" modified="2025-10-08" version="1">MSQSLADRWNRNSAVRGLAFGRGAVCSSWASSHLTGRDELQRPESRLEVGSVGLEVVEGAGNGLLDLGGVLAARAVGRDLVEGRRAHVGGCRRCRWVDWGTRRIERGSPGGKSLEAASDFGWSLEFGGWLGFAALKLCGGSTCWEWQAVWLTKKWACLRTTATGSAQQTHNSSIHLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNS9</accession>
    <name>A0ABR3VNS9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047130471" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="397" mass="43159" checksum="C215046B8BE8EB88" modified="2025-10-08" version="1">MKSALLTAAALLGTAQGAVHKMKLQKVPLSEQLESVPINTQLQQLGQKYMGIRPRESHASAVFNGMMADTTANHPVPISNFLNAQYFSEITIGTPPQTFKVVLDTGSSNLWVPSVECGSIACYLHQKYDSSASSTYKPNGTSFEIRYGSGSLSGFVSQDTMTIGDITIKEQDFAEATSEPGLAFAFGRFDGILGLGYDTISVNKIVPPFYKMVEQKLVDEPVFAFYLTDTSGQSEVVFGGVDKSKYKGKITTIPLRRKAYWEVDFDSISYGDDTAELENTGVILDTGTSLIALPSQLAEMLNAQLGAKKNYAGQYTVDCSKRDSLKDITFNLAGYNFTLGPYDYILEVSSSSCISTFMGMDFPEPVGPLAILGDAFLRRYYSIYDMGANTVGLAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNT4</accession>
    <name>A0ABR3VNT4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="72"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="649" mass="73496" checksum="D32041F99C375693" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNW1</accession>
    <name>A0ABR3VNW1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Flap endonuclease 1</fullName>
            <shortName evidence="10">FEN-1</shortName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_876</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="10">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="12">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1843593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="376" mass="42848" checksum="98732631985B08E6" modified="2025-10-08" version="1">MGIKNLFSIIKEEAPEAIKESDIKNHFGRKVAIDAYGPAKTTSHLMGMFYRTLRMIDNGIKPLYVFDGAPPKLKSGELAKRFQRKQEATENLEEAKEVGTAEDVEKFSRRTVRVTREHNAECQRLLKLMGIPYIIAPTEAEAQCAVLARAGKVYAAASEDMDTLCFNTPILLRHLTFSEQRKEPIQEIHVDKVLEGLNMDRKQFVDLCILLGCDYLDPIPKVGPTTALKLIREHGSLDKVVDFMRNDPKARYTVPDDWPYEDARELFFSPDVRQADDPLCDFKWEKPDTDGLVQFLVNEKGFSEDRVRSGAARLEKSLKSSQQSRIEGFFKVLPKTEEEKAAHKRKLEEQHEAKKKKLKEEKKEKAKAKAKPRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP88</accession>
    <name>A0ABR3VP88_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="579"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="605"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="641"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="677"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="714"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="750"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="786"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="822"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="858"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1030" mass="112416" checksum="21F3D7BE6F43269A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPI3</accession>
    <name>A0ABR3VPI3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="214" mass="22311" checksum="DF8F300A531A91CF" modified="2025-10-08" version="1">MGANGPKENPAAAASASTPGRGPAEGCGGEVGPDPEPGGGEGGVDGVDGVDDVEHEMYISILAVACLAAPAPPPLTVNAPTIVTRDEGFSDDGWAIRGFANPNCQGEGLWYFHGQGPRDHITVPHIAASHASMRGPKVFFEYSGTHTVWKKRDLDGEGGEGDNNNNNNNNNNNNNNNNNNNSTLEVRDPTLAGGLSISLCVSEPVLAFRVRKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPS0</accession>
    <name>A0ABR3VPS0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="185" mass="19479" checksum="82C6D9FD50C2B4EE" modified="2025-10-08" version="1">MSLSCRYAAQCCARQLRAAPIRASSSFFLQQQQQRVTRRYNSTDAGSTNPKIAAIVDQISQLTLLETADLVASLKSRLNIPDLPVGGFAAAPAAAPAAAPAEAEEADAAPAAAEKTLFTVKLVSFDAGAKPKVIKEVKNLLGLSLVDSKKFVESAPKVMKESVPKEEAEKIVATLKELGAVAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPS7</accession>
    <name>A0ABR3VPS7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase III subunit RPC6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47688" checksum="3B1DD50C1B0280FC" modified="2025-10-08" version="1">MATDNQADDSAKLKILKDALYEEMRQHGSETRLFTQRDLLDLNIIPNQNVMLLVRVVQGLCDDKLLVGTTNHHAGLAWRWRSREEAKKYTSLPNDETVMVYSIIDEAGADGIWNRTIKNKLNMHEAVVKNCIKYLESKGYIASMKNVEHPNKKMYIKATLRPSERATGGPWFTEGELDTAFIQELEGIVFEYIKTKSAYRGTQSQSSLSSSSGALTKAPKKGTILGSDPTSRGIKRSATEISTDDGTPAPSSRTTLNTNNTSKSRAVYLPMPAGYKHYPTVAEIAKFIHDTGITNNTTLSQADIQQLVDVLTYDGLVEPVYSSSSSSNGRRRVRGYRVTRAMKQDTVPFHKRQKEREAGVGLDKPLVVGAEPLTNGLTEAPCGRCPVFELCEEGGPVSPSKCVYFLEWLDLEDAAAAVAPPAGTTVAASVELPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPW5</accession>
    <name>A0ABR3VPW5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="322" mass="35037" checksum="4D140A28B0D6929E" modified="2025-10-08" version="1">MASRSLFAASPAALRRVATQARDAAPRLGPLSLTFRRSKHSSTSAIAYKAIRRRHAPLPVEQQTPAWSAQAAVSNILYETPVPSAAPPKRHVLNCLVQNEPGVLSRVSGILAARGFNIDSLVVCSTEVEDLSRMTIVLTGQDGVVEQARRQLEDLVPVWAVLDYTNSPLVQRELLLAKINILGPEYFEELLAHHREITAESAEAGETGETTLADAAKDFHPSRLVASEALRLKHEHLKNITYFTHQFGGKVLDISTNSCIVEVSAKPSRIDSFLKLIAPFGILESARTGLMALPRSPLYGPDEDSPMKEADEVVDASQLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ53</accession>
    <name>A0ABR3VQ53_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="299" mass="33964" checksum="66D34905EE15B70C" modified="2025-10-08" version="1">MSTSQVKHKKAKAKAATEGVPNQPSWKGFIATPYDAALMVEAARRGEIETFEKFPPRDIIDTYVYSGAIIVRHIRNPDDKNDNWRWRDGKAWTPHRLTQDGFFIYRELVRPKDTTTPLADLDYERNNAETLTPFLGQHLARARSKENGLVKKTLTFKVEGAKYIVIAYYTVQDALSGNLPRPRHHPRWPFDRDDDIVLNSDLWNHDERLKLKDDNGEAAAPDWRGWTNLGEVPLPGADDDDEDQMDEDQMDEAEDGAVKQGVMLDVLCGMEKKARVTFTEETTGPVKVEQGHRGDSEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ95</accession>
    <name>A0ABR3VQ95_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20264" checksum="3C3EE145D98834FA" modified="2025-10-08" version="1">MCLFTTSVLILKPGSCTTIRHHGEQEAIIYAVSGKGALLTQPRGEGSNNSSNSKTKTSDVNDSSNPDDADDEEEDDEEEDNEEEEQPERHDLSAGDFALIPAWTEHQLVNDSADEEADDDDNKVPVDEAVKAWAGDDGIDDGEACRGTPANGDRSSSQGEDFHLVIIRSGGQPVEVHLTDWGGPEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQM1</accession>
    <name>A0ABR3VQM1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037791">
        <property type="entry name" value="C2_fungal_Inn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
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        <location>
            <begin position="862"/>
            <end position="875"/>
        </location>
    </feature>
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        <location>
            <begin position="899"/>
            <end position="916"/>
        </location>
    </feature>
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        <location>
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            <end position="951"/>
        </location>
    </feature>
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        <location>
            <begin position="1041"/>
            <end position="1054"/>
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        <location>
            <begin position="1082"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1103" mass="118465" checksum="39D5CE68A1B814E1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQM5</accession>
    <name>A0ABR3VQM5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
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            <end position="321"/>
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        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="395" mass="45602" checksum="926B70FD48123AB7" modified="2025-10-08" version="1">MTSLNAQARAPAFPDDDDEWEYEYSTTETETFYITLDLSVRDFLERRTQDPAHTTRTGYRVWYNPLFGAHEPQASNSDLLDDKDADDEEPPEREEVDLDTIGMPSPQKVAKQPIDPLLGPTDNRDGPSSQRDKPVEEIQILDLHSKEPLVSYRNHLFRGSWCENIGTEMIFTPHDENDALPALRHLPNNMDLLAASSTRINFREAVLVPKDEEEVSDKPFLGYGYTEEDIPERYRRNGGVYIHVGGDKTGHRQPQAHFLEDLIALKRKRGETDEVTVQPLETRQNKLMVEDEEEERRRRKVRLDHARNARWREKRKEDRELGLGSPERSYVPRTRAGRWPKRARRASLIRRDSGPISRFAATTRDLRDGHSTPTPAQWEDLGGSSNRSETPPQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQN9</accession>
    <name>A0ABR3VQN9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
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        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="267" mass="28163" checksum="64CDAE607B008695" modified="2025-10-08" version="1">MAPKIAIVYYSMYGHIRQLAEAEKAGIEKAGGTADLYQVPETLSDEVLAKMHAPAKPTDVPVLEDPSVLEQYDGFLLGIPTRYGNFPAQWKAFWDKTGKQWASGGFFGKYAGVFISTASQGGGQESTALAVMSTFAHHGIIYVPLGYAKAFGILTDLSAARGGSAWGAGTFAGGDGSRQPSDAEKELATIQGEWFYKTVAKSVDVSSTDVEGQIAQTPSQEPETQETAAETAAETGNGGGKEKKQDAKKSKEPKEGPCGLPAKCAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRG8</accession>
    <name>A0ABR3VRG8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
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    </evidence>
    <sequence length="640" mass="68883" checksum="E33D7FACC9E8D83F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1C4</accession>
    <name>A0ABR3V1C4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000606">
        <property type="protein sequence ID" value="KAL1835559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="868"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="868"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="907"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="998" mass="108519" checksum="D8482D37ED32DADE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V218</accession>
    <name>A0ABR3V218_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000754">
        <property type="protein sequence ID" value="KAL1835308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="150" mass="16188" checksum="05F73E23EEEE0288" modified="2025-10-08" version="1">MRRISLQPTKRTSKTWRPHQAYQQDLAAYEENLTATHEAYQQNLAAYEQQVGQWAQESADAVAAEAENYAGGYVGHVGDYGDGGYGGYGGYGDYGTSGGAADLMAQQEAHAIANEMQHQALVNAQSLVATDGIGNVIGGSDQIVYVERYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V238</accession>
    <name>A0ABR3V238_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000571">
        <property type="protein sequence ID" value="KAL1835667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="647" mass="71502" checksum="42EAD989EEE2589F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2T0</accession>
    <name>A0ABR3V2T0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000557">
        <property type="protein sequence ID" value="KAL1835711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="72"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="484" mass="53216" checksum="3E1AECD564F161ED" modified="2025-10-08" version="1">MQATTDRAMEGNIPIASVSWFGKNCKYRDPGDPTDAGLYEPIARAKDINSVAIGTLLDIFANRRRVLEAVAEYFAGVHTWFPIIDRPRLEQELEESWSNLPAETSVVVLCMTLIARPPAPNSNKGIHDAAYHTVKGTLSTVQSTVELSIPLVQSELLLALYEFTQNKPLQAYLSVGRCLHMTRVLGWHEPAFWCVGNDIAKAKELKRCSVLWWAMVYVDCLLNIGYQDQTFPMHTMGLAIFPAVPLPSTFDEYLSQFGAQDPADTVTFPETGSALSLINALQYLSNPAMSGHDPRALSEQILPHAQQTTSGGGAMIALLKLNSAGLLGSINPSPTAWPLDTHHTQAQAARIITSVIARVNAKADEIIEWQDVRQLLERGAIEPCWGFAMCYASQLLISHANGALLDPMWPAKIANMRAALDEVAKRWRIAERYCTTVQTAFDNRYGEVARPATSSAAASRRSSLCFETRGVPTGNNPFSRRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3B5</accession>
    <name>A0ABR3V3B5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000442">
        <property type="protein sequence ID" value="KAL1836242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="218"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="364"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="659" mass="71114" checksum="CA65F986DACC07DA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3E5</accession>
    <name>A0ABR3V3E5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000440">
        <property type="protein sequence ID" value="KAL1836259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="369" mass="41144" checksum="6FDAFB1CA44C0C8A" modified="2025-10-08" version="1">MPSRKSRHSSSSPRGSKDPEIFQQLGRAVLSYSLKKLAEQRQARSEASDQDRSRSHPGKNSSSSRSRDRSSARRSHRDAPRDDGGELHTLITQLAIGALAGGVRRLIKRRRESKRKAAASSTTDINSTTRGTRPGFPHMPAVDPELSASLDFVTAELRGATDTIRRLASTSAPVSQHPTHDCAVRDALAVEADRLTASLTRLQVSIINMQNLHPALEAPGDAGARHGNRREKGNRGIVEEMVGGGRRRGDWMGDGETWKKGRRSGETERKDRQRGELLRERRLGDWDERHSRRTEGGEDVLMRGETARTPPWSAPLQESLNRRHRRHRDHGSSRDEIPSTGLEHRRSRRGARDGGQTPHRHRLDPVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3V7</accession>
    <name>A0ABR3V3V7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Urea active transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000406">
        <property type="protein sequence ID" value="KAL1836472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUR"/>
    </dbReference>
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        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
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        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="118"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="73745" checksum="80E6CEF4D09D2F93" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3X9</accession>
    <name>A0ABR3V3X9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclease S1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000404">
        <property type="protein sequence ID" value="KAL1836489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35763" checksum="BB2310EC68862D76" modified="2025-10-08" version="1">MKLSSLAVITTAAAPGALAWGGFGHITTAYLASDFVSPQTATYLQTLLRNDTPHYLAGVATWADSVRYTRWGRFSSDFHFIDAKDNPPSSCGVDFERDCKKDRGCVVSALHNYTMRMMLDPAKKATLQDVVNLEALPVWERAIAAKFVVHFIGDIHQPLHTENVARGGNGIHVLFDGRRVNLHHVWDTSIAEKWVGGIRRRPYEGARRWADELAREIREGKYAAVAGEWLRSANFSDPHSTAMAWAGESNAIVCSHVFTSDPEDMHDQELGGEYYEKAAPVVELQVARAGYRLAAWLDMIVEDILGSEDEGKSSSGRPSTDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V403</accession>
    <name>A0ABR3V403_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000453">
        <property type="protein sequence ID" value="KAL1836171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="63"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="680"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="768" mass="86508" checksum="A83B5F6B86F9D193" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V435</accession>
    <name>A0ABR3V435_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000407">
        <property type="protein sequence ID" value="KAL1836466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="35"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="270"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="294"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="422" mass="46656" checksum="02251A9CE21AA21F" modified="2025-10-08" version="1">MWATARRMASHRTFTSPALKFELVAQCSVRMTCTTRARASILTLPHGIVNLPIFMPVATQASLKGLTPEQLEATNCRLCLNNTYHLGLKPGQEVLDAIGGAHKLQGWNHNILTDSGGFQMVSLLKLANVTEEGVRFLSPHDGSPMLLTPEHSISLQNSIGSDIMMQLDDVIVTTCPDKVRMREAMERSVRWLDRCIAAHKKPESQNLFCIIQGGLDLDMRRECVRQMLARDTPGIAIGGLSGGEAKDDFCKVVAACTELLPDLKPRYVMGIGYPEDLVVSVALGADMFDCVWPTRTARFGNAITKHGVLNMKREIYATDFGPIEDGCGCPCCRPVDQEGAMGVTRAFVHHNAAKETVAAHLLTLHNVWYQLDLMRRAREAIIQDRFPAFVKEFFANLYPDSSKYPSWAVDALRGVGIDLLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4D5</accession>
    <name>A0ABR3V4D5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4889</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000391">
        <property type="protein sequence ID" value="KAL1836600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="270"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="13">
        <location>
            <begin position="734"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="693"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="786"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1836600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="91987" checksum="9B50CCD12CCB25B4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4I3</accession>
    <name>A0ABR3V4I3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_5066</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000403">
        <property type="protein sequence ID" value="KAL1836492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="28"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="733"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="433"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1836492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1063" mass="114062" checksum="2E113A08E7A959B0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Q4</accession>
    <name>A0ABR3V4Q4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000440">
        <property type="protein sequence ID" value="KAL1836253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF510">
        <property type="entry name" value="D-INOSITOL 3-PHOSPHATE GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51938" checksum="6CCB152C44D83BE6" modified="2025-10-08" version="1">MAPIRRPAEPQIANRYVGTTRLARSFDPSDPSRGIMKPARTTVETNKPQAFTVITCKMRIFLVQTAHGLYAPSGGYRSNYGFLRQLGAYGHAVGQTCYAFDNEIDDAVAKARANGVDPQVKHLPDVDLGPDFETGTKRLDEKAFLESDALSSSLAALVNLWRTQIADFQPTHVVFNDGLTMKITENMVKMHQHQFKRVCVVHSAEQLPFGPFCGRFSGHCVSAEAENRMIRHVDGVWAVSQGVRDYALNHGGLQTTFMPHSTWTYLDGGRTPQRRDNVQKTEVGLVNPCALKGLPIFIELAKRLPHIRFITWKGWGTKKVHLDELAKLPNVRVEQTTTDTEHDIWDRIKVLLAPSLWLETWGAVITEAQLRGIPVIASDVGGIPEAKLGLPYLVHVRMATGEVDPVTGDYIMPQQDIAPWEAALRSLVDDDTTAYEALADRTARTTVQWIRGLDQHAQEKWLLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4V5</accession>
    <name>A0ABR3V4V5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000389">
        <property type="protein sequence ID" value="KAL1836612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="127" mass="13226" checksum="42BA5BC5B7159BE9" modified="2025-10-08" version="1">MAPVQVQVQIQVQIQIQVQIQKQVSAPRTRHPHPSDPPGPSPLLAQHHPESGGGRLDRTPTASSDARDATAKDCGETASSFNCHDDRDCGCVAIGDCGGCGVNENPCVGTGGSWGADDAEENDTKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V553</accession>
    <name>A0ABR3V553_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000352">
        <property type="protein sequence ID" value="KAL1836902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="9">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="628" mass="67547" checksum="2B452483D43CD528" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V555</accession>
    <name>A0ABR3V555_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4531</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000354">
        <property type="protein sequence ID" value="KAL1836889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1137"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="449"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="770"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1254"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1276" mass="137108" checksum="D3A8DC8D98930813" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5L4</accession>
    <name>A0ABR3V5L4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000371">
        <property type="protein sequence ID" value="KAL1836741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="52"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="284" mass="32004" checksum="FF63DD133CC72D05" modified="2025-10-08" version="1">MTGNPRPKVSNDVIATFITVLVLGRIMERKRCLGLAELHDPKSLGVEPALDLVLIHGLNGDYLSTWTYTGGSGSDVSKPVCWPTDLLPTALPSVRVLSFDYNADIYGNTSVNKIRCHARSLLGRLAQREGPPGRPIVFVAHSLGGIILKQIFFSTPHFGGDRSRWLSIARSFSPLLPWRMSWRRGRYHPLVDALVRGSTEISDLCEDFKFLAPRFQIASFYETRKWPGTNRPILDKLSALMFVACEESMPLDKHHVEICRFWGAEDDGFRHTCDFIMRMAGWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5X2</accession>
    <name>A0ABR3V5X2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000328">
        <property type="protein sequence ID" value="KAL1837111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="57"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="484" mass="54651" checksum="AB6840820C12AB23" modified="2025-10-08" version="1">MTESVCDADCCGRQETVRDGFQEFSAAATGHASWQLTGVAEGKYLRRLRKRESLVDYIPVRALSWGPLSNVYLVWSKDEGRFCVLKAIRKDVIDGPDRFPLRQYALIRAERDAMAEANSEWLVKLHSAFQDSNRLYLTMDYLRGGDLGSLLDRCGKLTERATAFCAAEITLGIEALQNLGYMHRDLKPDNILITATGHVKLADFGFAKSPRPTHNKKYYDQLLDPSLFRTGAGLYGPPRPRPRMRGNRWKATSRLGTPGFIAPEVLSRRKYSDEADYYPLGVIIYRCIVGRMPIEHSNTSILNEMVVSCDPWQLPYPRRTSFHAWHIITMLLSESHRRLGHRNGTRDIKNHAFFRANDIDFDKLLDSVPPVPFNVQHDQNHVPQRPPSGAKTDVRANGSGARQTPEDLTPVMSTVVDSAGGAGEPASGVEELLPYFPLEGHRWETILGDGKTVDAEEDEEEEEEVAPERALPFVGFEYRRFEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V619</accession>
    <name>A0ABR3V619_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000357">
        <property type="protein sequence ID" value="KAL1836866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="200" mass="22358" checksum="0BC23777897E81E0" modified="2025-10-08" version="1">MSAAPTTKTFGKSTRTVPHPSEKAQKWYPVEDEAQPRKVRKAIRPWTPRSSLQPGTVLILLAGRFRGKRVILLKTLDQGVLLVTGPFKINGVPLRRVNARYVIATSLKVDLTGVDQAKIEEVSQPKYFTAEKAKEKASEEAFFKQGEKPQKKEVSSTRAADQKAIDKALIANIKKVDMLASYLATSFSLRKGDKPHLMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6A9</accession>
    <name>A0ABR3V6A9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000309">
        <property type="protein sequence ID" value="KAL1837299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="123"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="509" mass="57212" checksum="8028A0D43FA28403" modified="2025-10-08" version="1">MDDDHTPAVPSPLNPEPKKVHVDEATVTREKRTKKDSLKKRESKGLPDSARATPDPKPEPPIELAPVRYKLAHPRPTDFDVPRGPVFTPHHEVHDPEGRTIEFCETSDHVYNKKSFHYTHCIADPTFPSIFYYRNTEPPPYGPHLAFEDAASHMFFDRSGMHVTSEKGFRMTRANVAVREGRWYWECRVTRGILKDRREGDPESHGHVRVGWARREASLDAPVGFDAYSYGLRDVGGQKVHMSRPKDFFPPGEAIREGDVIGLEIRLPSERLQRKVARGEYNPAIDASDEPEENQPPEVPDVIRDRIPIRFKAHIYFEKIDYHTTKELEDLMNPSPSSNHPSAEPPNPNHRSPALRTLPGSYIRVYKNGVLMGTPWTDLLSFLPPASRQAQPSGGRDALDDGTLGYYPAVSVFRGGAVEVNFGPNFWFPPPAEDAEMGGVPESAGPGRLRPVCERYDEQIVEDIVYDIVDEVGFWIQDGQPAVGRPGTDGKAEATVPGRDEIKELVQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6F9</accession>
    <name>A0ABR3V6F9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2406</name>
        <name evidence="4" type="ORF">VTJ49DRAFT_3980</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000305">
        <property type="protein sequence ID" value="KAL1837337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045031817" description="Fucose-specific lectin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57142" checksum="F1996E3FE5140968" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7J4</accession>
    <name>A0ABR3V7J4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Nibrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000278">
        <property type="protein sequence ID" value="KAL1837610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17741">
        <property type="entry name" value="BRCT_nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="761"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
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        <source>
            <dbReference type="EMBL" id="KAL1837610.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1531" mass="169761" checksum="E7AEA02DD0691670" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7L3</accession>
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            <fullName evidence="5">Biotrophy-associated secreted protein 2</fullName>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
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                <person name="Drula E."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="191"/>
            <end position="209"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8C0</accession>
    <name>A0ABR3V8C0_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3537</name>
    </gene>
    <organism evidence="3 4">
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000274">
        <property type="protein sequence ID" value="KAL1837661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="159"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="508" mass="53783" checksum="9059CF207A69D9BC" modified="2025-10-08" version="1">MHAQISFLVSNTAMTWIPRSFVWRVTMSAVHKDPTIHVTAWTNSSDHDVYHLGLADLVEQEGTLSLIHIPLDLYPSLLQPILKILLPPSRDPYYRRRSSSSTSVNNEECHPHHHHGSFLNISVTPIECSIVCDAAWAESVFRPALARLSRDQSRTVAISGDTYAVLNVYGTGMDAGSRVADLTSPLALAGIPIFFITTYYSDYILVPVKARQAVVKALLAQGFVFSGEDHSQLISSPSASIHHHPPLTTTPTPPSTIDDLQHRTFTLLRNRNVTPLIHPGLTLVQCTGASSNPTTSTNGTTTSISSSRHHHHTSSTSSSSRTGGRRPSAPPSWVDTVDARLYTALVAALAAQPRFLSVTLAHEDPPSLLMDRALLPVFGGAVMAGTAAAVDEDYYYVEYDEHGSPGGGDGVPSGGGSAGSGGLVPIFLDLADLPFEATGIVSGVAGRLVREMRGEGVGGGGGGGGMGCELSYLSTARSGAVILSAEQAAKAMGVLEPVLKREDGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8M8</accession>
    <name>A0ABR3V8M8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anucleate primary sterigmata protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000232">
        <property type="protein sequence ID" value="KAL1838184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="435"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1610"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="652"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1350"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1626"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="605"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="679"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="772"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1350"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1397"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1475"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1522"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1558"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1591"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1626"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1645"/>
            <end position="1657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1666" mass="184802" checksum="79149F6C427054C7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8S9</accession>
    <name>A0ABR3V8S9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_3124</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="JAZGSY010000243">
        <property type="protein sequence ID" value="KAL1838030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF3">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046425044" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1838030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="221" mass="24981" checksum="BED9CD1DAD04CB5C" modified="2025-10-08" version="1">MVSFTTLVTAVAAAVSTVTASPMEAFKRGIQPGTGYHDGFFYSFWTDNRGWVDYNNGPRGSYSVSWSNVNNWVGGKGWNPGPPRRIAYNGTWNNYNQNSYLALYGWTTNPLVEYYIVEAYGTWNPSTGASRLGTIEDDGGIYDIYRTRRVNQPSIIGTATFDQYWSVRRQKRVGGNIDTGKHFDEWRRQGNLQLGQWNYMVMATEGYQSSGSSHIEVRSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9W8</accession>
    <name>A0ABR3V9W8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000206">
        <property type="protein sequence ID" value="KAL1838572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="235" mass="26613" checksum="1BF2CA857FD49AA1" modified="2025-10-08" version="1">MATNEQPNIIWDPAGLLGITDAYTTEVVQCIGVAPSKNNARCGWKKEGENADPIMTQLRNMAANSPRNVTRDDLRHLAQISVCKLHDKQVARIVQEWAPLVQRAASIHEAHVRERNTLNNTILLQQAELKACYDLIGVRDKHVSEWVSLTDLQKNGLLDSWARDSPESPQRNPDNACAARDQAKRLMRQMEDELENPRTDNAALVQRNQELMAEVEELRSRRSGLRGVLSHRTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Y2</accession>
    <name>A0ABR3V9Y2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000201">
        <property type="protein sequence ID" value="KAL1838658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="490" mass="55644" checksum="815AE117B68AA30C" modified="2025-10-08" version="1">MEPLHVTEFGSDRYLEKIHQSRANATPAPAPSSSLPESKFILPIRGSNLSSAATAAVTEQSEQRPSSVSSESHRRSSIPFDRLFAALPNELQIEIIASLPLSDILNLRSASRSLHALVSLNETPIARYHLDHHVPAYAKRLYPPPAGVPLNFHYLCGIWHRLHVAAKLSYLICEWVSKEMFFRNTEEKKREFAPQRERMRRRLIPMVFTCFHFFETYRKLHLQYIAKHGYGLSRTPYTTNPIETEILNMYDDRTLYQVHEIFPLVMASFDRRLRPPTYVGRVERSLRGYLRDKPPEEVHVAILCLGGLREVEKIWEVKGYNARRAAVDAWYASISRGASEPEPKKRRDMLGKLKRKKSALTLGKTTSNDNVPASGISASSSVAQGKQPESLVFCTSMAAGMPMGPLSMEEYRILLSDLPGLRKIWTETAEAMILDRKIVERPSDIRRNAQIFTDLISEKVADDEDEWLYGTVATGTLRPNLDAIDEDPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA25</accession>
    <name>A0ABR3VA25_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000199">
        <property type="protein sequence ID" value="KAL1838689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="108"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="640" mass="68703" checksum="26AC33E412F095A0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA67</accession>
    <name>A0ABR3VA67_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 14.8 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000244">
        <property type="protein sequence ID" value="KAL1838008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14629" checksum="77A13A1573756FE7" modified="2025-10-08" version="1">MAISPTKFAITTRQSANWSDAKRRVIAAYRAWIRAAPEIQTMYGVPHPVSAIRSRIRQEFERHRYVNKLPVVDVLLHKSNADYQETMNFWRQTNHVMSFFKEENFRGEKRLPSNFITGFLEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAM7</accession>
    <name>A0ABR3VAM7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-glycosylation protein EOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000188">
        <property type="protein sequence ID" value="KAL1838883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="43844" checksum="9B774A6A2CB5A46F" modified="2025-10-08" version="1">MSTRAKPTAAPPSSPPSPSLLRADRNSHNHRSARKPPLFSDHVPIGQTPSSTSIQPQPPPPPPAPPLPGGTVRSTLLQPRVAVALGVSKKWYPALFLCRLASIAPGVLFGLPSALRLLATLHLMYLDRVLGDGGGLLYRRLVAGVRTGAAAAGVAAGGVGEDGNVGVGGGSGILGSGGLGSSGYDAAFEARLRLTEALLATIWCCASGYLSFFFTDCLMSRWLLHYTPQATIVRLLTVDAMNAYLTSWVLHLMGGFEDPRLVLPAWILISTTLTVLYHITQRKINIRKETSMSISVFSIASFVSMVALLAQLNSNRSDYPDIPLVNLARKASQMAGRLALRLMDGLRNDMQTDGPILSTTSRRNDVQQLAPMQPNFALDLLSVDRRVLRPPAIAYLCRSILVEDPLNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAR4</accession>
    <name>A0ABR3VAR4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000192">
        <property type="protein sequence ID" value="KAL1838806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="122"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="601" mass="66820" checksum="5AD43AC0B61DC4A5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAX5</accession>
    <name>A0ABR3VAX5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000189">
        <property type="protein sequence ID" value="KAL1838866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="416"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="785" mass="85475" checksum="6F91B330DAD40729" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB04</accession>
    <name>A0ABR3VB04_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000188">
        <property type="protein sequence ID" value="KAL1838882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="121" mass="13671" checksum="9B81ED3776E7E8D2" modified="2025-10-08" version="1">MSGETEIQNLKSRDPFAEADEDSGQTTQTQEYIHIRIQQRNGRKTLTTVQGIPAKFDHKKILKVIKKEFACNGTIISDTESKGMGEVIQLQGDHRLKIKEFLTDDENGLGLDEKTIKIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB05</accession>
    <name>A0ABR3VB05_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045124059" evidence="3">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="348" mass="37406" checksum="B6E0F5D21A741F57" modified="2025-10-08" version="1">MAFLQRSLLWLICLAALFVAIDGAIQLGLVSSMVSFIHSSARTPVLVAPPGQQVWAIGSFPENLVTDPGHVANAAGGTALVLVGFGSVIALSLEKRSRKKRNTSSPVFYLWCLIVLLSFLLTLGALIYAFVETANTSGQTIDEAVARANPPPAKYPLGRWTPETWGNALLELPLASPVQRRRIHGKVNSMPARLRRTFHYPSSDDDDDASTPSTPEFLDEQEQESLISTLTAQNHARNASHARLLFLLPALSTIPFLLRLCFLTPKDTRSTSPLFLLPLLGLSSLLATTWLLARLEPTETGFAILDAKFRSGNTATTTSTAAAITAQGGAVARGRGLGLGWDAQQIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBD2</accession>
    <name>A0ABR3VBD2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000176">
        <property type="protein sequence ID" value="KAL1839082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724:SF2">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="54" mass="5933" checksum="3BD27CD08A28AAA9" modified="2025-10-08" version="1">MCMSATCPTCNKKTWRGCGNHIASVLSDVPEDEWCTCEPKVEKDGKKYPPAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBJ5</accession>
    <name>A0ABR3VBJ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_1799</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000171">
        <property type="protein sequence ID" value="KAL1839180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07836">
        <property type="entry name" value="STKc_Pho85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="337" mass="37897" checksum="856F7D2FCB470500" modified="2025-10-08" version="1">MDGKRHAASFQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLDSEEGTPSTAIREISLMKELKHENIVALHDVIHTENKLMLVFEYMDGDLKKYMDAHGERGALKPHVIKSFMYQLLRGIDFCHKNRVLHRDLKPQNLLINNKGQLKLGDFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAEMFTGRPLFPGTTNEDQILRIFRIMGTPNERTWPGLSQFPEFKSTWQSYSIQPLGTILPQIDPLGIDLLGCMLQLRPELRISAADALKHPWFADLIGQSGVPVQQQQQSMTSQIPGQPQMMAPPYGQVPSQAGYGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBU9</accession>
    <name>A0ABR3VBU9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketohexokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000170">
        <property type="protein sequence ID" value="KAL1839203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31239" checksum="1D2DC26F95322162" modified="2025-10-08" version="1">MKHLILVGAVYMDTILTVPHFPQEDSKLRATNVQVRRGGNVGNTLEVLRQFLATTPATEDARILAHLVACLPDNRSRAAKEVLKSFGPDHVTEDDYHDVTAASEGRTKRQITRLVIDYARCLFRVGHEQPASSYILRSAETGSRTIVNHNPLPEMMLDEFEGIVDDFVARWPQDDSWWHFEGRIPETTLQCIRYLRQKIPGCAVSVEVEKPGRDGLTELAAEADVVFYSRSWAQLTHVLYMGRRRRRCLRTRKWQICPPPSCSDYNERQQHAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBY2</accession>
    <name>A0ABR3VBY2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000162">
        <property type="protein sequence ID" value="KAL1839355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="76944" checksum="0BB91857DE25678B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC35</accession>
    <name>A0ABR3VC35_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000195">
        <property type="protein sequence ID" value="KAL1838743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="223" mass="23811" checksum="1103E49563D39110" modified="2025-10-08" version="1">MATNDTPLTSPSSDVMESAIQTQMSLVSSFDSWLASKATAAPPGPLRDVVAKVQQRLDSYKRWLAAASKTPHSLPEEEVDDQSWDMEARTQADDGSVLVTGPGSGEPIRMSVEEKEAQDLMSDVGSMVQVCSSFAKAQTTLQALIQTVCETEKESSHLTQDPDATVKAYIRNLQDYNEMKDIGQQLISLVAENRDVPVITSHTSSGLIAAVTLAAPGAGPGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC48</accession>
    <name>A0ABR3VC48_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_1525</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000158">
        <property type="protein sequence ID" value="KAL1839424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="15">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="149"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1839424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="416" mass="47913" checksum="B44E4262A3BE6191" modified="2025-10-08" version="1">MALTYQQSKLVKDTIPALREKGEVITTTFYRNMLRDHPELKNYFNSVNQKNGRQPRALTSVILNFASNIHHMSELIPKFERMCNKHCSLGIQPEHYEIVGKYLLQAFAEVLGPAMTPAVFAAWERAYWVLAKMLIGREAQLYRDFDKWTGWRKFKIDRVVPETEDIYSFYLVPVDGKKLPRFHPGQYISLRVHSPEGYMQARQYSLSEAWREDYYRISVKRDEGARYSNSVSETYFHPGLVSNILIDHMPAGSTVELTHPCGEFFLDVNNNTSNMPLVLISAGVGVTPMVAIANTVTRTQPGRPISWIHGSRRTIPFEDHIATLRRQHHPYFRTNIFKTHLAASDIVGVTYNYDFRMDLAKVNPDDLFLTNSATEYYICGPEQFMLEMSDYLKSQGVPASRVKFELFSTGDLAFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCD4</accession>
    <name>A0ABR3VCD4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000172">
        <property type="protein sequence ID" value="KAL1839162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="597" mass="66810" checksum="2675D5326CAB8325" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCK8</accession>
    <name>A0ABR3VCK8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000151">
        <property type="protein sequence ID" value="KAL1839540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="213" mass="23262" checksum="60CD9C0E3083D180" modified="2025-10-08" version="1">MASSDRRHWLRRRLAKPLPLPAPPLAVPVRRRTMDPKRPRRLAMPMPASGTPDAAKMAGAEDVYLAEFAAVITNYGYDFLVELVQLDSVDEVDFTPTLILLDPPPPEHMPREPKTSRFPVDMEVPRHPVLDAEREDLRLLAALKACRADDFGLVLLKALADAATPAILVRPAALAGTVDTAAKVPGAITRTTTNPGSRLGLECNKNIGDPVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCY0</accession>
    <name>A0ABR3VCY0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000161">
        <property type="protein sequence ID" value="KAL1839372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="607" mass="66418" checksum="C67AF5A75C78F556" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCY8</accession>
    <name>A0ABR3VCY8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII28-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000151">
        <property type="protein sequence ID" value="KAL1839548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="188"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="348" mass="37474" checksum="0016078BDA8FDCED" modified="2025-10-08" version="1">MTSPSAQPSPYPLHTQLPSDAAMSANRKRAADGATTPALKRRKASTLSAASGATSAHPLRQTTFPDDPNMSSFTVRSPSVDHDAMSLISASQVSTSAAPVKKKRGRKSNAEKMREREQTPSVAGGRAPTAVSGVSDGTGRGGKGSTAGAAGAGDEAEGEDEGPTEVAATADARTKEQKEEEIRLKNMLVGALSEDQFNRYENWRAANLSKASVRRLVNATISQSVPENIVLGMRAVAKVFIGDIIESARRVQGEWIETLHEKQTDLPTPPPTAPATQDTNSEVEAPEKEPQPDDRRGPLRPEHLREAMRRYRKGFEGGGVGMQWVFHQQQQGGVERFPTRTGGRRIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD66</accession>
    <name>A0ABR3VD66_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000139">
        <property type="protein sequence ID" value="KAL1839820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="118"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="360" mass="39821" checksum="40EC75503B0D854E" modified="2025-10-08" version="1">MSQLEKSVMSKRSGRQFVEDGMEDDQQQDRQGIRTSTTSTTTSTPTSLEPSPLVRPADGQQHGNVDDNPLFLSTGDGRCRSQTELVHDVFHPPPTPQQLANSMIEAERGLPSTGRPANFGVVVPGVYRSSFPKAEDYEFIEELKLKTIVTLVRKDFPKGYDEFLQRNGIQHAVFDMKGTKKESIPIATMRAILSIVLDRRNHPLLIHCNHGKHRTGCVIGIVRKLSGWHINNIIREYRAFAEPKVRDCDIDYITAFELANISNLFRGDNAPSTTPISRMMSMVSMSTSSTDLVSLSSPFRTGPSSFGYSPFVSPGFLRATAFALILLATWLISGCMLARERGAEWTGAAEELLNEAAGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD89</accession>
    <name>A0ABR3VD89_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-repressible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000170">
        <property type="protein sequence ID" value="KAL1839193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7339" checksum="582B56928EE67FC1" modified="2025-10-08" version="1">MDTLKNAGNYVSDKVQSATHGTSKEANKEVAKDSNASIGSRVSAAGDALGDKAKETKHDTSAEAHKQAATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDB8</accession>
    <name>A0ABR3VDB8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000139">
        <property type="protein sequence ID" value="KAL1839825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="351" mass="37953" checksum="A0ECA188EE42A4BD" modified="2025-10-08" version="1">MAKVLLTGGSGFIAAHILDQLLAAGHSVVTTVRSAAKAAKIREAYLSQVASGDLVVAIVPELSRADAFDDLIKQTPGLEVVLHTASPFHFNFTDPQTALVDPAVTGTTSILHAISKYAPTVRRVVVTSSFAAILDEARTTDPATVFSEASWNPVTLADIHRSPATAYRLSKTLAERAAWDFVRDQGDKINFDLVTINPPMVFGPLAHPEHVGELERVNTSNQRVANLLRGGWKQEGGVPDVGVAWIWVDARDVAAAHVKAGLEVPETGGKRLFVTAGKYSNAELARIVRKHFPEYAELLPGEEALAAGEIPPEEKRYRYDNSATDKLLGIKYRSFEESIVDTVKSLKKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDC6</accession>
    <name>A0ABR3VDC6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000152">
        <property type="protein sequence ID" value="KAL1839522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="1">
        <location>
            <begin position="45"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="199" mass="23202" checksum="ABAA6EB2C9F2B5A5" modified="2025-10-08" version="1">MDLYYQVDPAKQWTDMTRYNSFVLNGVKYYSEGFVYVANDSSIERQKAVNNNEPMQPRKKSDDDWVARILEIRASDEHHVYARVYWMYWPDELPAGTHDGKKIIQGRQPYHGANELIASNHMDIINVVSVTSQAHVRQWYEENDEEIQHALYWRQAFDVRTYELSSVELVCSCKTPGNPDKLLLGCTTETCKKCRTSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDG6</accession>
    <name>A0ABR3VDG6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mei5 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="80061" checksum="F686D3E49311BC43" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDM6</accession>
    <name>A0ABR3VDM6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000153">
        <property type="protein sequence ID" value="KAL1839501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="25"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="326" mass="34932" checksum="A34141F398E4F0FE" modified="2025-10-08" version="1">MIDVIALLFSISVLMGILTLVVLVRLWLKRTRGFFLRVEAPGIVTLILLAISFSLLGGAVAWGYGRHGADLAADLAADKALRLVAVSAFFASIAVTTARASALTSLVEVLPVDWATTALLTLTGLTFCLNLAVALMIVIVPWGDRMLKECESDSSVWFGIVVQMGAVLTVCLDFGMAAIAGIKGWRLCITHGQLVERIGFVVGMSFGICAITISIMKLAQTTCASFTYDSTYTTIPFAILTFAEPVTIMLAAVVPILRLYFTKPTHTLRGKPLGEDVADPWPYAEGPVAARRGSTGRSCSRCGKCLYLERRQPLDSSTPYRGGGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE03</accession>
    <name>A0ABR3VE03_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiotic recombination protein DMC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29901" checksum="8F758D3F2EF798D7" modified="2025-10-08" version="1">MVESTGPNAGGFLVPSLPSPAPTTSTVSTIRPDLPHPRRQPLRPGSAKEDQVRDFISDRMSHITRRFVKKTGGASLDGDPGDDVEGYKSMAELCKDLDEVINIIWLSGTPSLQIPSLLNIASEFNTWIPSFPPSPTAMLGILHKLDHCFASLLAGEDAETHEPLPGFDKGLRSGLSRTDMVRCKSTVQHTRVLVVDVMSKREGEGEEDGGESRDQTGDEYDDSGAEGSRQRGGLGLEDDDNEELHMDVARVYEKTLVKLGETLAESGVGEIQMSAD</sequence>
</entry>
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    <name>A0ABR3VET4_HUMIN</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23341:SF2">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN HMG-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23341">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEINS HMG-A AND C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="290" mass="29765" checksum="3FD571DDBF4F1A24" modified="2025-10-08" version="1">MASTPPPADEPVKRKRGRPPLSPSKRKTKPRVPGRPRGRPPGSGKNQQAAQAATTTTTAATGTRTSARVAAAAGVTKTPAADPTVPVRRGRGRPRKDANASLVGSAASKTAVGAAAKRKAREREDAVLDAASAARLSAAAAGEEVVTPVKRGRGRPKGSGYKQKAAAAAAGGAGSGGGDEENATPVKRGRGRPKGSGWKQRAAAAAAARERETEEAEEIRKKAKAAGAGTGRRSVGTDEEGDHEEDGDGEEEEGGEGEGEGEEEEEDQVVVGDVEAERRMEQWELCGSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEU8</accession>
    <name>A0ABR3VEU8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="691"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1043"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1072" mass="119335" checksum="A59DD6253D7B8D9F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF08</accession>
    <name>A0ABR3VF08_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000143">
        <property type="protein sequence ID" value="KAL1839716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047170283" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="17"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1839716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="592" mass="65851" checksum="CDC79CC539748F75" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFQ2</accession>
    <name>A0ABR3VFQ2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000117">
        <property type="protein sequence ID" value="KAL1840332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="555" mass="59467" checksum="B05CBDC9AC9D8C93" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG41</accession>
    <name>A0ABR3VG41_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="769" mass="87548" checksum="E49D3A1F02388991" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGB0</accession>
    <name>A0ABR3VGB0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000102">
        <property type="protein sequence ID" value="KAL1840703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="74" mass="7826" checksum="C5790C6469C073CE" modified="2025-10-08" version="1">MQSSHTPSSAATSTATSVLRAISRHPRLTAAGFVLVGAGLGFRRAARRYHENELARQRAAPGFYVTVDRSGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGF7</accession>
    <name>A0ABR3VGF7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47862" checksum="A32F2F5B1A917A8C" modified="2025-10-08" version="1">MGFVVEYGNYTLPVAISILVYLLVLRTEPITRNGSRLRKPPDTLPLLGNGIKFLQSRWKLLAWFDDCQRRFGYETVSLSVPTLPPGVLIQSPENLDYVFKNEGVLFGKGDFVKGRSWDLFGNGIINADGDLWKRQRKAGLAFLNTANLRVLTEVALPQYLAETLDDVRSRAAQGPVLVDLQHVFLDITTKLMGRMAYNMEMRADDEFTRCFDHASGVTASRFQNPLWRVTELFTGQSFRHSLGVVKDFGQRIVAGAVQDRERKATKAEEGSSSDTKLERISGSLIQSLLDALGGDEATVADAALTYLSAGRDTTAQALTWTFYLLAQHPEAVAEIRREVDCIRSEQEEQEQGSVAPSPSLLTTLTPSNLPYTTALFHESMRLYPPIPIEIRQCLSPTQLPDGRFLRPHEESHILRLFRFVALIVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGK0</accession>
    <name>A0ABR3VGK0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046265438" description="GPI-anchor transamidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="7">
        <location>
            <begin position="587"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="8">
        <location>
            <begin position="1215"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="963"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="979"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1311" mass="144220" checksum="C5EE42C5B9E50790" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGZ0</accession>
    <name>A0ABR3VGZ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="118"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="535"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="794"/>
            <end position="1049"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
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            <end position="102"/>
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            <end position="355"/>
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            <end position="464"/>
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    </feature>
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        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
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            <begin position="505"/>
            <end position="514"/>
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    </feature>
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        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
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        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
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        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
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        <location>
            <begin position="914"/>
            <end position="934"/>
        </location>
    </feature>
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        <location>
            <begin position="995"/>
            <end position="1020"/>
        </location>
    </feature>
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        <location>
            <begin position="1036"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1841070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1049" mass="113364" checksum="AC882DC7F700D7B6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHI5</accession>
    <name>A0ABR3VHI5_HUMIN</name>
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        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">VTJ49DRAFT_7738</name>
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    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1840783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
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            <end position="260"/>
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    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="597"/>
        </location>
    </feature>
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            <end position="769"/>
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    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1840783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="968" mass="102541" checksum="CFF281F003774715" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
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    </protein>
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        <name evidence="10" type="ORF">VTJ49DRAFT_7266</name>
    </gene>
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        <name type="scientific">Humicola insolens</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR002464">
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    </dbReference>
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        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="90"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="332"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="775" mass="86691" checksum="AD7794EFD4807AB3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHL7</accession>
    <name>A0ABR3VHL7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000106">
        <property type="protein sequence ID" value="KAL1840601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="72221" checksum="1924909E8DE20CBA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHL8</accession>
    <name>A0ABR3VHL8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="427" mass="46879" checksum="3DA95FFF922D1F65" modified="2025-10-08" version="1">MATKEDREMMERISRLASQINRHKNEQAGFVPAPPSGPPSRPPPRHHNSWRRGGYSHRGGRGRTPLFRNRTLILNGGTPQTPPGDADSGTASDASTSSWVTKHDRHLQLINSSVYQKDAQARTAAIEQSRRQKFAQRDKQERAKLISHLNRMAAGGAFGAANPRTAAPAKYEIAIQGIRFIVAKNGSKLVKVPDDVNAAKATPKMAIVGGVKFYRSKNGNLYRHGIVKAQRQSGRVRKINVPCKQFSMTGSCTQGPRCRYIHDPHKVAICREFLQQGECANGDNCDLSHDPVPERTPTCLHFARDSCTKPDCRDFGFYGYCPKGAACPDRHVFECPDFSNTGVCKNKGCKLPHRERASVLRRGASGGNNNGAGGDDDDEMEDVSSDDDGESIDDDDVDSDEVDEFIGQDEDGDGGIAFAEQKDFIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHP2</accession>
    <name>A0ABR3VHP2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="190"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="331" mass="34801" checksum="93568261860B61C1" modified="2025-10-08" version="1">METTAVPDQQPAPKLVTHEAGFQAFDTYPWTSDRDFLKGLMMTLGPANLNPKATAADGFHRQRSLSMALQARIWWYTSRFNLQIDHTAYLAYTLTNPSSSPDARILARLEEIAQRMASINASTSGEASSSTAPATSSTATASSSQPAAAADSSPSAAQNIPSWQLNAPKVDLSKKADDAGVHSAAPDGTPYPENFQAIVEAVTLGKPIPGIKEIPDIVERPPGITPFGKLKPPRKPWERDEPADAAATSVTALLAAGGGIFGDVAENEFPPMPETQKEGEEAQQQQQQQGEQVQQTQGGGNDDGGQTSSAAGAAAETTTTPTTTNTTTPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHT8</accession>
    <name>A0ABR3VHT8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="461" mass="51373" checksum="FA5CF7E8E7A74A2B" modified="2025-10-08" version="1">MATTTDSAAFLPFKMHVTSDNTGLWRIRQTEEAAKTVSELLQKDMEIPHHLLALYGTGAPPSALRAAYAHNDTYQRPALPPHRDLPVVPFLPWPRAAEPYFGREEYYPDFLRFFQEEGTGTGTQQQSQVEGKGEVAQEVKEGGKRREGDSPLLTRLFAGFLHPLIQLMYGIEWAQEAVVAEGLAQAAVHSGEIGEYLLAAEELARKQQQQQQQTQESERGESILSLLNSVRTNKKLAHAARNSDSSKIRDGVMARAKDEMLSVAARVHVRPEEVEEKTAEMFDAAVFVAAAAALERVGRPGNKKPAKIDFFLIPFFVTINAQPWIPPETKARLLEWKIRMDLLQYAARGAPELSVEKLKSYQPQKPDAGGSGALTEIITRLHTTPDDGHSIKLGRALGVCRAICQPYEEEQPPKPWLAIKGDEMWKKVCHLVVDSVEAPGPRWVRSTGFDEAWEEIPDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI96</accession>
    <name>A0ABR3VI96_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7016</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="373"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="524" mass="56259" checksum="660EF82F21068459" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIA2</accession>
    <name>A0ABR3VIA2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="766"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="789"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="836"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="231"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="733"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="970"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1081"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1243"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1102"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1162"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1262" mass="140159" checksum="9664871871E6EAC2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VID0</accession>
    <name>A0ABR3VID0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="499" mass="55115" checksum="A810CD839DA6844F" modified="2025-10-08" version="1">MTMLTPPSEFLAACPKFRVLVLGNPESTKQELFTKIFGVDLEKRSVDEAFSPSHTITTPLDLRNQNSRVDIFTGLNFGTGSGGDDEANYSRVCDFLTAHASPSTPLQDRIDVIWYCVASEEDRPISDLERRFFGVIGQGGLCDVAPGLPVVLVFTKYDDFVERVRLEWSRDAQEKGLSKVAVSYILRDLATKRFEQEIAAVVVPRVCVSSPDTDEDARSFEVLAETTLARLRDRNVKYAFAAAQRISALICTRYCADTASEYFEVSTAHARKLHGVDTRDILPNFFAKAVQLFNLRDPSSVLDPTPAPPTESSILARILLATFDSSRRALVQDSLLRSGTDAASLVLALTPHDRAVLLAQTLAGVLLFLHRLADSQWPHGVLPASYALSEETLARHVEDLKASEGERKAVLEEVEASTVFTTCTLRRSVAELLINAIERADRIRDGKAGSRHPGHARTPVMVEDDSELKEIATRFANDKTPMLPCGLSILKLTPEPERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIT7</accession>
    <name>A0ABR3VIT7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000080">
        <property type="protein sequence ID" value="KAL1841300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26071" checksum="9061ECD422805A86" modified="2025-10-08" version="1">MLNISPFSYGMGIAQVYDQGNTFPASVLDIGEEQLLKSFSSAINTVAAVSLALNYPTLPSVMHSLVNTYKKVLAVAIETEFSWPEIEELKDRIANPEAYAVAAPAAAAAGPAETKEEEKKEESEKEESDDEGFGGLLFVPPNLVLFRNSLLTTPLATKRNDCLTVLLGRQRWFGSDRDSGNLHHPWLRRSVAAQWNTLCLTVTLLVRLVWKRQVVLTKEELPALAGSVMVSCLRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIX5</accession>
    <name>A0ABR3VIX5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="575" mass="64327" checksum="F2A76AB11BE87715" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ78</accession>
    <name>A0ABR3VJ78_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58672" checksum="4352674293D16031" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJB9</accession>
    <name>A0ABR3VJB9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="288" mass="31545" checksum="D3E22C054EF83023" modified="2025-10-08" version="1">MSNILAWCSRRAGGIAMLGTIALSYLAISSELEAQRHDYKYQSTGSLSAPPAYNARTARAWVKLFAWYCLFIHFLVFVFPLRSCWAVFSITRSLRQSQRARALRDLKFGHRRRGSSTSLSSSETLTSSRDVSSTSSSEAGDLDIERYADGDIALDRVIHAIVIPNYKEEVETLRETLEVLASHSQARNTYDVSETLTLHIPLPPPPRLETSIGQNLSPRLLHVMHFALGVGGGNGWGIRSSGEPLSPIFAPNADSCIPGLPCDGGTGAKCGDQGYGLDQRVLQEIPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJN9</accession>
    <name>A0ABR3VJN9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000053">
        <property type="protein sequence ID" value="KAL1842109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046734893" evidence="2">
        <location>
            <begin position="27"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="301" mass="32964" checksum="60699D0CE316E07D" modified="2025-10-08" version="1">MAMGLSLAALRLFAVMATLLVATVLAAHENELPSYHYGAPIPVECMNRSSETGEHIENAAHEIEWVPFPVCNETNKPLEFYYGVEDEQNCTIAMVSDPFFHLLEFYIHNDAPLSCRLPARPRPHAQEVVGEKPPQQEYIPLVFALAGTLQLSHMHISTHLNVLIHSTPKHHIHPRDSGVLDSATAYSTSPRAAHRAGSSTRRLVIGDPLPLSLSVRWFPTPDLPKVAGKVEWSGMGGHVYASTVFYSLLSFCAGAVVSGAYFFGSVLPRRLRARRLGGATPLGYGLNGVGSGWGYQKRNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJS3</accession>
    <name>A0ABR3VJS3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="136" mass="14847" checksum="2A53F583858478CE" modified="2025-10-08" version="1">MAAPPLRRWPTGTSTPPATARWVSGESFFPILLNNNKRQESALRQFHPRPIPHQLTPANHPTTPPDRSNPNKKHTKTEPTTSSPKTTSATSRPSPACRPRRPTTASTASAAPPSCPCSKRSCRATSGPRPRRTRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK34</accession>
    <name>A0ABR3VK34_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39062" checksum="D9B3CAB184C059F8" modified="2025-10-08" version="1">MASPQDPAPAAAPAAETILVADDNVDEQDDGASTYGSIASSSTSIASSVMKLRQENGRKYHSYKPERGYILPSDEQESARLDLQHYIFCLTFDGELHVSPAGRDGKPLKRVLDAGTGTGIWAMEWADEHPESTVIGVDLSRIQPDFAPPNVTFYVDDLEEDWTHNEPFDFIYGRMLTGGLTDWPKFMKRAFDNLNPGGYLELADITFPAMCDDGTLSPDSALLKWNELSVKAADLLNHSIESCKHYKRQMEEAGFVNVVEKLYKWPINSWPKDPKYKEIGAYTEQNFVNGLYGLSVALFTRALGWSAEELQVFLEEVKKDLRNRHIHAYWPIWVVYGQKPEGETAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL07</accession>
    <name>A0ABR3VL07_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF128">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="684"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="804"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="819"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="950" mass="108473" checksum="FC529C8ABCC0C3F0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLA4</accession>
    <name>A0ABR3VLA4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dopey N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5437</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="381"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1329"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1417"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1860" mass="203160" checksum="762CDA71202743F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM75</accession>
    <name>A0ABR3VM75_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4126</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="110"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1842797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="231" mass="25785" checksum="6F1E8AC2521749CA" modified="2025-10-08" version="1">MRLAPPRSSSHHPRHLQLLKSTSTCASGDKLPTETSTMATSTDDTNFAATVPADQAAAGTDNTTTNTKPPTSPTTAAAQAAAARLHRPILQTLPDTRPQSFDEIYGPPENFLEIEVRDPRTHGIGRHMYTDYEIVCRTNIPAFKLRQSTVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDDVIEGRRAGLEKFLKIVVGHPLLQTGSKVLAAFVQDPNWDRNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM83</accession>
    <name>A0ABR3VM83_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1843000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="203" mass="22786" checksum="DE964200A35932B8" modified="2025-10-08" version="1">MEHMNEVYRRRNRSTAYYVLSVILGTVALSYGSVPMYKMICQQTGWGGQPVRAHGADPNADISARLEPVTSAPRIRVTFSASVSDVLPWKFVPQQREVRVLPGETALAFYTATNTSDKDIIGVATYSVTPAQTAPYFSKIQCFCFEEQRLAAGETVDMPVFFYLDPDLLKDVNMRKVETVTLNYTFFKARYDDNGRFKGPPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMX2</accession>
    <name>A0ABR3VMX2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="482" mass="53001" checksum="43D7EEFD1703E0F0" modified="2025-10-08" version="1">MFRRHWSGLPADPVFPENLKDLGYFINDVDEVRSIEDPDYYFKYFISKNTRWNERNRFAFDQAIQKVLKSRLADAGFTTVPLPLGTPTTEPHVPILTSANAATASRVVVLFGETCQALGVFANRVIGGRGGVNRGSVLGFIKAMQQQHCSATDPAPPGLVVTNPGELWWWPEGRRGLTQTDRHRIPMASAVHARYHAPEVNEIAGNRNVVEHVVSIFESVVLGERFVRKDAKVDVIVVGDTAEAVEKYLDDDTVFDRFDDRLNSLVILGGTYSSNDFNTERFKRFIKERGRAYILHDAPLDSIVAGPSGNPAAGGFTSYGCPVYSAGPKAHYIETMLIEAQTAVLDWTQEVAVKGETYRNEKIEIISETEEDDGTWASYMKKAAEESKQTDGAGHATTDETSKDVAENEINNSQPEQIDHGVDGSPSKTDDSVAGTKENSNSTGATEAIGEMKLENDSAGDGPDAEEMKELVEEVENLKIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNE9</accession>
    <name>A0ABR3VNE9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="385" mass="41221" checksum="08674A21087FA653" modified="2025-10-08" version="1">MPRSAKQQQQQQQHDPPAADTATGVTDSMGQLAHQTAGEVKEALQVSLPKGRGSGAAARLPNPVRFALAVVLSFALEALGRSFVDHWTGGEVAAIAREASDESVERWAGVVWKLFGLTLGWFGDYDGYDLAALALLSHGPATFLTTIFYGIRAVTAGAYLGVEVVSAFVPFFLLRRLSGAHSAAPDTPNRDIVADTSIQVLTSLQAGLVYSVVLFLGGRYVLPDYLVLYFKDIPTIRPAADATLVGFSNPTIQLLSLLFGLAARSFIFTPLVATPRTSEDEKNEAFDPINATLGQTVAWNLWGYTTRTKVSLVRTAVAMLFTAVGTYLDTALTIKGVESYGAIVYAGVWVIAALVTGLSLRYVGNCRYVKPEAARLICSPDDTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNZ6</accession>
    <name>A0ABR3VNZ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tip elongation aberrant protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF456">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1361"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="792"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1493" mass="162423" checksum="71217CFDB5EC3C40" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP14</accession>
    <name>A0ABR3VP14_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68291" checksum="11CC7F737B67E556" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP39</accession>
    <name>A0ABR3VP39_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047286589" description="Aldose 1-epimerase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42898" checksum="6E62B175275C5423" modified="2025-10-08" version="1">MRLTYTAAVGAWLVGAAYGSSNAKGPDSNGKYWIYGEGIKAAFIPYGASISDLVVNDKNGVPRDIVMGFDKASSYETDESHPHLGSVPGRYANRIKNSTFEIDGEVFHVSPNENPTPEHPKGLNTLHGGADGWDWRNFTVVSHTDSSITFSIVDPDGKEGFPGEVVSFITYTLGNLTWDAKIIAVATTKKTPIMLTSHTYWNLDGFANDETDLALNHTFYMPYSGQRVDVDNILIPTGDILPNKKGSVNDFWSAPKQIGKSFSDPEIHGNCGYNCTGYDNCWIVNRPSTHNWLAEDNIVASIWSDWSGIKLDIYSDQDAFQMYSCNFQDGTFPLKSTQGRPDGPRTVPKYGCVVLEVQDWIDGINHPEWGRLHKQVFGPGDDPFSDGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPA0</accession>
    <name>A0ABR3VPA0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF106">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="328" mass="37830" checksum="A16D535F09C08D60" modified="2025-10-08" version="1">MEENNLIEPLPDEEMHDEITSDYDSGEAETRFGSVTSSVGGHVWEYGRRYHAFRYGRYYLPNDEGEYNREALRHTMLKDMLGGKLYAAPIGPNPQKIIDLGTGFGEWAIEIGEEFPSAQVIGVDLSPIQPHWIPPNVQFVVDDIEDEWAHANDFDYAHFRFVNTTLRDNDRTLRNVFENLKPGGWIEIQDIYPRATSDDDTIPPDYALGRFYALLEPVVRERYGTDIYLMERMPQLLSSLGFVNVQRRVFHLPLGEWARDRHLRLQGGLFREIMLEFVGAVAAKPLLEAGYEREEMDEMVRDVAAALGNRRIHAYMPIHFVWAQKPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPD1</accession>
    <name>A0ABR3VPD1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1305" mass="141391" checksum="3CEB1A8C04914DDC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPK1</accession>
    <name>A0ABR3VPK1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="330" mass="34147" checksum="4ED7ACCF8AFE116A" modified="2025-10-08" version="1">MENAILDPETGHPLPEDAIIRVLHITSRVHVYTLPPNTISTTRGYQAATWTADPRNPIFTGRLRVLETSFSLPSSSKSTPPSPPPAPAPAQQSQQQQQQQQPTQETNDAPQQHLKVTILLEDPSSGALFAACPYDHPRAVQPTADSSRFFALRVRDPSGKQRATLGVGFEDRAEAFDFGVALQEAGRGLAAMGVEGFSSSSSSSSSFSAAAGGAGEGVVGSGSGTTGAGKEGGEGGAGGGKDWSLKEGETITVKLSGTRFGRRAASGSSDGTSGGGGKETTGQSLAAFALPPPPPPPSSTRSAREERAQKRLSAQAQQLGFDDGQFGEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPN5</accession>
    <name>A0ABR3VPN5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="33"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="226"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="445"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="840"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="100259" checksum="0FE0858537472E1C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPV4</accession>
    <name>A0ABR3VPV4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="81" mass="8844" checksum="F94410387D3A5379" modified="2025-10-08" version="1">MDPSKTTSSQHEQQHDSRSVSVGDSFCHYNEGNPPSKAADSLRAALHAHSANPGPAIPKDFNVQQEGTKEERQAKAKEMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ22</accession>
    <name>A0ABR3VQ22_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="29"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="237" mass="24627" checksum="8224CFC070F9430F" modified="2025-10-08" version="1">MSAPKVLVVLTSHDKLGDTGKPTGWYLSELAHPFAVFTSHNFAITLASPQGGSAPLDPSSIDAAADDPISRTFHSEQSALWESTVPLASLLNRGVANQFDAIFFPGGHGPMFDLAVDPVTQALVAEFVAADKVVAAVCHGPAALVGVTVGGEGTPFLRGKVVTGFSAEEEREVGADGAVPFVLEERLVELVGPEGRYEKAAEKWGEKVVVDGKLITGQNPASAKGLAEEIVKAVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQF8</accession>
    <name>A0ABR3VQF8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="842" mass="91222" checksum="19955D7C0FA772B1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQI8</accession>
    <name>A0ABR3VQI8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="1">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="110" mass="12907" checksum="12342E4CB73E78F0" modified="2025-10-08" version="1">MDFDNLKKQVSNLTLYDIKAGVRKVQNAVMNYTEMEAKVREATNNEPWGASSTQMQEIADGTFNYQTLNEIMPMIYRRFTEKSAEEWRQIYKALQLLEYLIKHGSELPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQT9</accession>
    <name>A0ABR3VQT9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="193"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="285"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1844269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="683" mass="75743" checksum="13EFB3EE8E28EE8E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRD3</accession>
    <name>A0ABR3VRD3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="191" mass="21798" checksum="BEA3C5CC002B79DA" modified="2025-10-08" version="1">MSPHKVTHSAIEHPDTMDDLLEPPTSSVRFHPHHSRDFALHKYLLLHEQHEFLRQHLDELRPSRQASICTPVSPSPAGSPTRRTSCSSDTPAIPRQRTHHRSSGGVGFKDAYRATVHRDDNDGHELNLDEEVALEEAKLCDVNEGMKRLLTELLNCETVRADAAFRTWVQCRLMDTERELRSGRRRRSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRD5</accession>
    <name>A0ABR3VRD5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="349" mass="37988" checksum="9E744853C3E35281" modified="2025-10-08" version="1">MTRQSLQLELAERPTGGIVPGKTFRLRRVPAPTEADLKEGQMLLESLYVSFDPAMRGWLDDRRSYVPPVQIGEVMRAMTISRVLASRSAKARPGDIVTATLGIREVGIVNENQVDPPMSSLPLGRVTDLLGVFGMTGLTAFFGMTKIGEPKAGETVVVSAAAGATGSVAAQIAKIAGARVIGIAGSDEKCRWLKEELGLDVALNYKDPDFKKKFKEATPKYIDVFFDNVGGEQLEMALARANTFARFVMCGGISQYNSNAPSGPSRAFFNVISQRIKMQGFIVFDYAKEYQTALAQLAQWVAEGKLKRRETIIKGGIASADEAFKQLFQGGNIGKLMIEVKKPEETARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRF4</accession>
    <name>A0ABR3VRF4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="1435"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1844225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1791" mass="197950" checksum="29F1EB5CC4A1D87D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0Z6</accession>
    <name>A0ABR3V0Z6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000653">
        <property type="protein sequence ID" value="KAL1835459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="117" mass="12384" checksum="D4BD5F368B055C7A" modified="2025-10-08" version="1">MANISRVTLTQDGVCSLVLATGKATHRAIAACLHLSGAGAAASIIGSGYPAASQDQAMAAGNHISQPSRWVHRSGTRCQRCPRVLSLQRQTASTDDLSSTSVTLLGRRRRPWWDSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1J0</accession>
    <name>A0ABR3V1J0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000575">
        <property type="protein sequence ID" value="KAL1835655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="69"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="362" mass="40473" checksum="77AC8E39417F4973" modified="2025-10-08" version="1">MRDPFPIPPIPALSRAVEPLAELLAMPTLPLHIHEVVGAALLYTAIQTVVSPVLSNWLFPQFYPRHHRAKKANWDTHVVSLVQSLLINALALWVMFADEERKAMDYEQRVWGYTGACGLIQALAAGYFVWDLGITLLNLDIFGLGLLAHAISALAVYTFGFRPYLNYYSPIFILYELSTPFLNIHWFFDKLNMTGTKPQLYNGIALLVTFFLCRLVWGTYQSAVVYVDMWHSIHRAPSAEYLDAAFAAVSDPTDPDANPMFFSRNPTTVPVWLTGIYLASNLTLNSLNWFWFFKMIKAVSKRFEPPKAAVAVPAGKAGAAEKPIKATAVEGTADGVAVQRRRAHSIEDVVPDTEELREGTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1M0</accession>
    <name>A0ABR3V1M0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_6207</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000565">
        <property type="protein sequence ID" value="KAL1835688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="40"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1835688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="226" mass="25014" checksum="9B3CCB9B2DE4D46B" modified="2025-10-08" version="1">MMSLAKFKAAHARRRTQAQDLLSSHTKHYFILGLVALDVCTILADLLVALIACDLDKEDEPWVAKTREVLHPISITFSSLFMAELLVTVWAFGWRYFKRWFHAFDAAVIVTSFVVDLATRGLVEEIVSIVIVLRLFRLFKIIEEVSAGAAEQMEEVQDELKKLKAENQALRKDLEAARGGGGVEQACVRGAPPQGISESAAVVLFPVSCTGRSDAVPTWKLPSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1W5</accession>
    <name>A0ABR3V1W5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000546">
        <property type="protein sequence ID" value="KAL1835752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23267" checksum="BBA7193EAD83F805" modified="2025-10-08" version="1">MRLSVPLVIALGSTVPGQLVVPHIHRDVFGDQSPLLSPAMPPTDTLPQLSSFIAREDVLLSDVMGRDKSISSFASSARDIEPTARLLDDPSRNTTVLAPQNSAVEGLGRKPWENPRDYDKFGPDAYQGPEGLERARRNIRRFVEAHMIPASPWKQGDRVRPVVGGGEVWWEEKGDTRLIQPDGITVVGVVGDVGNGQVWIIKGVRDYLKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2S3</accession>
    <name>A0ABR3V2S3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000469">
        <property type="protein sequence ID" value="KAL1836074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="102"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="328" mass="35738" checksum="43EDBBE63DE05DF6" modified="2025-10-08" version="1">MAPSVLYPPVQLSPAASLELAQTAPAVLKSSPSSVSSSPLFSLVGGSEKSEQWIQYENLILTCLRTGDDQSARECLERLVSRFGADNERVQALDGLVKEATAKNNGELEEVLKEYDQILSENDTNIPIAKRRIALLRSMGRASDAASALVQLLDFSPTDAEAWSELSDIYLSQGLYPQAIYAIEEVLVLAPNAWNIHARLGELQYMAATASGGAANGSYQKYMAEAIKRFSRSIELCDDYLRGYYGLKLVSKALLNGDGAKTSKQTEEGDFALPDRSTLEKLHELATAKLAEIVRRAAAKERGWRGYSEAETAAARELLAQDTAAVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V367</accession>
    <name>A0ABR3V367_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000528">
        <property type="protein sequence ID" value="KAL1835831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="187" mass="21087" checksum="F8527466B7F72A51" modified="2025-10-08" version="1">MSPDKTFFDFTVKDKTGADLPLSTYKGKVVLVVNTASKCGFTPQYAGLEKLWKTLSEKHPDQFVILGFPCNQFGNQEPGSNDEIQEFCQINYGVTFPILGKVDVNGSSADPVFTWLKSSTPRFFGMVDRVMWNFEKFLVGKDGTVKGRWSSVTKPEALEAEILKELENLLISRWVTHLYNTDVNKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3P3</accession>
    <name>A0ABR3V3P3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">VTJ49DRAFT_5217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000417">
        <property type="protein sequence ID" value="KAL1836393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="89"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="455" mass="50028" checksum="3486C09B64B2112E" modified="2025-10-08" version="1">MVRHKKDNFARGGKHHNRPPPRYLRRPGDNSDNTGDETKNTTGTSSNRPPFKAACWDLGHCDPKRCSGKRLLKLGLMRELHLGQRHAGVVITPNGKRTLSPADRPLLEQYGAAVVECSWARTKEVQWSKVGGKCERLLPYLVAANTVNYGRPWRLNCVEALAAAFAICGRREWAEQILAPFSYGAAFLNINDALFKKYAACEDEDAIKKVEQEWMERLDREYTESREDGDPDDLWAGGNVNRRAPVGSDDEDDDDDDDDDDGNKTDNDTKSIDGIYLGKKPSQPASPGTTEPDPDDPGAERERDRYALPPSDSDSDDAAEMEAIRRKILASKPFATPAADEPSSQSPTNPTAQTTAKKSHIATIPRPEPQYKSDSDAEPDSDNDKGVGSDSDQDDDDGGGGEGDDAEFDSIIDATPVTDRIGLIKLQKERARIQSAANTTRKTFSSGSVAAPRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V441</accession>
    <name>A0ABR3V441_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000405">
        <property type="protein sequence ID" value="KAL1836481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="58" mass="6067" checksum="DF286922B3CA3F94" modified="2025-10-08" version="1">MAAIWGYMTPLALDQVPTAPYLPGTCRSGSTQPRNPEHPPGSQRPTAKKAGDEGAACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V448</accession>
    <name>A0ABR3V448_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000398">
        <property type="protein sequence ID" value="KAL1836539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="360" mass="39536" checksum="DB152D7FCFD44812" modified="2025-10-08" version="1">MALNWFLDFADRTLLVPGRSAPHLTTAVTASPVLSGAGSCHSCPDITPMALSVTQSVGGTGAESLHLSQRELLRLESELFDTAKYCGISASATPTTQYLTVLTWSDDAKHGTITLFEIHLSSPSRRESISSSSTSNNSRTLAIRRHRRPPLPLSITHRSSRYPHATHIRPVAAMELVPRRILAGLRADAEMRKLALHRDRTTGRFRWTARHIQSRHRHANPRLARLCGVDEDIDSEVRGLPRTEGEPHGIVATIPHLLALMHTTTSIVERTIANGTPVTTELVKTTDGERVRAVSLGGGVTGPRHRGRDVHVVVLIPDGGDGDERVRWVEEPIFWTDDRGGLPEFRQDQGVDDGTMEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V465</accession>
    <name>A0ABR3V465_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000421">
        <property type="protein sequence ID" value="KAL1836372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1431" mass="157001" checksum="1B50F901295E0A23" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4H7</accession>
    <name>A0ABR3V4H7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neurofilament medium polypeptide protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000382">
        <property type="protein sequence ID" value="KAL1836659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047325807" description="Neurofilament medium polypeptide protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15449" checksum="6719E65FB0735A67" modified="2025-10-08" version="1">MRLPLAAVGFFLAVASGSQYANDANLVLNAAGVLLPRQNGRVSLQTFTGALGGAPASAIVKSDDPERPFEVDGDTFNDFEAAANRACDNQKNVCANLANNGTGNFKVGDCDLQNDQCKTAARAAAVREFPAAVLVDSNDEFDFFCDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Q1</accession>
    <name>A0ABR3V4Q1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4722</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000372">
        <property type="protein sequence ID" value="KAL1836730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="330"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="406"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="581" mass="62908" checksum="A30054F904D8D7DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4S9</accession>
    <name>A0ABR3V4S9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="7">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000388">
        <property type="protein sequence ID" value="KAL1836620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="739" mass="83503" checksum="B85C399991BB8C92" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4X7</accession>
    <name>A0ABR3V4X7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000362">
        <property type="protein sequence ID" value="KAL1836819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="99" mass="11224" checksum="D350DDCE66C8C9A6" modified="2025-10-08" version="1">MAKRAANQDVLAISPASRDQVKGLLALPAELRIKIYDLVLWQPTRIYPEPFWHHRVQLIFGHQDKGRLVEGVIEATERSLNAIEDLRVIADLGIGTTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Z0</accession>
    <name>A0ABR3V4Z0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000363">
        <property type="protein sequence ID" value="KAL1836810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046736228" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="44985" checksum="07AA98712A471205" modified="2025-10-08" version="1">MRHLTTSAGLLLLQAPVLTQGLPLPHKLRGDADKPVAGDKQTPILPSSPPPTPTPTTTFITTPTPVLESKPVSTRTTITTVTTSTSSSLPSSQPNANNNNNDHLDGDLTQELAELATLRLQLAALAREVREREAWLARQSSAVETTADCDGLGCVGRVFLRRVRHVVRVVGSGGGHGHDVGGTGGRSVPVEEPAASGKGIPRPPWRGGAGLGVDESAAGYGAGAEQDAEGGFDPFLIGLSAAVLMSVVALLATGGYSSCVDAGRISSLCSCVGCRQRRSLPRVEAEQAFWERMDFGEQGLEPWPRYTDSDEPRYTDGDEKRQIEVEDEVQSDEEEDMISWNEKRAEQWQTEEAMTSSDESHEEPQTEEATVPIEEPESETEESTMAEEIMAFRSAVDLVEALIAGEEARMASRRRPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5H8</accession>
    <name>A0ABR3V5H8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000338">
        <property type="protein sequence ID" value="KAL1837019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="417" mass="47533" checksum="C83C097B72FBBEB5" modified="2025-10-08" version="1">MVRSNSQGVDRQLDQPNFQEAAYLGDLWIACHEATDDPVEEDHRAAWALVSGAITNESVDAIFVINIAQGLCHHPLRTKVRRFTPWETDVTHRRYVDSGIPKSQDTGAFCLADVETTAKEFSDYVERYAFSGLTEAFEGSDSIVRDVFSMIARHYYSLPDDDHDATWNTRKSPGQKEFLQKLVYLWFAIRLGSGSAWLDGEERLGIGPGSGDGHPLPGRVSVPRLVVAQFDSIRCERFYKPYTQDVLRRLEALLGSHHKESWFTVFLATFLLLHLTSDSSADRHRHSKQNQEVNPRETRYGALNHPLTAWVEEVHQSAAMLLAHWHYFKRCDLTMLDQDDVDDGKPLAFLEPYQSEFVKDMASRMKARLPFIPTTPAQGCWEHELFWVSKMFTSKPGKRGWSAPEIFTRANPSVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5L1</accession>
    <name>A0ABR3V5L1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Assembly chaperone of rpl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2887</name>
        <name evidence="3" type="ORF">VTJ49DRAFT_4333</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000335">
        <property type="protein sequence ID" value="KAL1837044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
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            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
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            <end position="393"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837044.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1843137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44124" checksum="FE0E1E5903416087" modified="2025-10-08" version="1">MAPTKPKTKSKDKAKNRARAKAAAQTPLVNPRELLAQATTHLEEGDPETAARIALTAYEHIGETGRQAGAALTLLGHIHVELGDIDTARNFFTAAVNVDQDGTLPEDVGGGAEKFLWLAQLSEEGGQDSVSWFERGAAVLRAQIQELTESLESRPLTRDAQEALIAEKRRRLADALCAVAEVYMTDLSWEEDAEQRCEALVTEATLLAPESPETWRTVANVRISQTRVDEAREALKRNLGLWWDLEPEDPAVPPFPARISLVRLLIEVEMEKEATEVTDRLVAEDDRSVEALYLGGYAKYLSGEKLKVQGQPEDVETWKAVWRSSRKWLTQCLKVFEQEEYEDERLGEHARELKESINKELGEPAEEEDEWEDTDDDEEWEGIDDGDEDTVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6I5</accession>
    <name>A0ABR3V6I5_HUMIN</name>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000301">
        <property type="protein sequence ID" value="KAL1837367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="615"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
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            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="235"/>
        </location>
    </feature>
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        <location>
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            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="684" mass="74479" checksum="6CD3A818A3F14C11" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6R2</accession>
    <name>A0ABR3V6R2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3757</name>
    </gene>
    <organism evidence="8 9">
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000292">
        <property type="protein sequence ID" value="KAL1837458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="802"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="802"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="958" mass="104621" checksum="7780BC4707588FBC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6U7</accession>
    <name>A0ABR3V6U7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000289">
        <property type="protein sequence ID" value="KAL1837492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="540" mass="59590" checksum="B102EE2183D14517" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Z3</accession>
    <name>A0ABR3V6Z3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000283">
        <property type="protein sequence ID" value="KAL1837549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046972364" evidence="4">
        <location>
            <begin position="17"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="5">
        <location>
            <begin position="26"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="382"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="477" mass="50950" checksum="91504DB9814DBAC9" modified="2025-10-08" version="1">MRVLETLLAVAAGASAATVSPRQAGTITVNLGQTFQRIDGFGFSLAFQRANLITNMSDKTKQKELLDLLFNRTTGAGFSIIRNGIGSTPNSNSDFMNTIAPNNPGGPNAPPQYVWDGKDSGQLWVTQQAVNLYGVKTVYANAWSAPGYMKTNGRDTNGGTLCGSPGAYCQGGDWRQAYANYLVQYIRYYAESGVNITHLGFLNEPDYVASYASMQANGQQAADFIRILHATLQREGLADQVGITCCDSMGWGNNANMMNAIRSAGVEGLMSTVTSHTYTGGPNGAVNYRNPVWLSEQCDLNGQWTTAWYQFGGAGEGLTWANNIFNAIVNNNVSGYVWWEGVQWPNPNTNEKLIRVDNTTNTYEVSRRVWAFANWSRYVRPGAVRVGTSGAPGGVRAAAFRNVDGTVAVVAISSSGSPASVTIRLSGSGVSGVSAVRAYVSDNTRNCENTPASVAADGSITGSVAARSITTFYILPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V702</accession>
    <name>A0ABR3V702_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000286">
        <property type="protein sequence ID" value="KAL1837516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="709" mass="78013" checksum="FBE3120AB9FC348F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7H1</accession>
    <name>A0ABR3V7H1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000267">
        <property type="protein sequence ID" value="KAL1837732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="99"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="382" mass="43037" checksum="A1B6D967B79C17C3" modified="2025-10-08" version="1">MAPVAVEVEPPAPLKDLAALKPQASYQIGGAYKEIPYNKFDPEAELGKKGHQAAKYPHYLPTWDPNQKYPPLEPFEHYDHGKDADPTYPNLLPKDKVTVTHLTPTIGTEVRGIQLSQLSNAGKDELARFVAERKVVAFRDQDFKDLPIEKALEFGGYFGRHHIHPTSGSPAGFPEVHIVHRGAGDDTIDKFFANRTSSVAWHSDVSYEAQPPGTTFLYVFDKPAAGGDTLFANAAEAYRRLSPAFRERLHGLKARHSAVEQANYSVLRGGIKRREPVIHEHPIVRTHPVTGEKAIYVNPQFTRDIVGLKKEESDALLKFLYDHLAYGQDFQVRVKWEEGTVVVWDNRVTQHSALVDWQDGQRRHLARITPQAERPYETPFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7T9</accession>
    <name>A0ABR3V7T9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000258">
        <property type="protein sequence ID" value="KAL1837852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="111"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="253" mass="27097" checksum="FD1427B45B140351" modified="2025-10-08" version="1">MDRQTIIETNRSLRLIKNELESLLEKGVLTDSAFDSITTLLPAETPLSAASRSTTTTTTTSSSVPTPATTITTPSTASSPAPPSYAASTAVPPSLPIRNNPAPPSEPPSKPVLAHARALYRYAATDPRDLSFERDDRVAVHEYMNDDWWLGSNLRTGQEGIFPRNYVVVDAQSEKQQPASSSAAAVPIPGYPQPQYAPGPGPYAVQHQQQQHEGEEKESKMAEHGKKFGKKLGNAAIFGAGATIGSNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V820</accession>
    <name>A0ABR3V820_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Gamma-butyrobetaine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000254">
        <property type="protein sequence ID" value="KAL1837891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="9">
        <location>
            <begin position="125"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="241"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="61207" checksum="0406F5E6726B85DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8C2</accession>
    <name>A0ABR3V8C2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000241">
        <property type="protein sequence ID" value="KAL1838058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="60781" checksum="CDDFF5AB51CE7B2B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8R5</accession>
    <name>A0ABR3V8R5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000237">
        <property type="protein sequence ID" value="KAL1838116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="112" mass="13432" checksum="C4325903915978DB" modified="2025-10-08" version="1">MGIDVSRRNRVPRPLTEDERARLDEFVDSIHYSTRYSDSEFEYRHVQLPKAMLKAIPAEYHDKSKGTLKLLWEEEWRAMGITQSLGWEHYEVHEPEPHILLFKRPLNYQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V926</accession>
    <name>A0ABR3V926_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000230">
        <property type="protein sequence ID" value="KAL1838207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="384" mass="41616" checksum="A90174BDA32F9E71" modified="2025-10-08" version="1">MRRALLSANPARILSRGMASHGAPRPVVPIIASNPSDQIHPVGPFYESIMRSKLPSHSKTEAPPVTAKPAVPPKPTPAPKQAEKAPEPPKQAEKPAEKVAEPAAKTEESAPEEKKRAGRPRKTKADKDEPTTNSSKAKSVPPPPPPPSPSTTTTTTTTTTQSSSHGLTPPLPPSSSEPIPPQQEDGPPSNRSSQTRGGIVFGSRLAGPGMSGEDEYRQSLLRASRSRVIAGVRVPPKPDEPDNCCMSGCVDCVWDRYRDEMEEWAAATAEVERRLGRTAESGRRVREGEEVSEEVGVTEASAEAVERGKGMRMGVHEEVADREGGLGMEEDGGGVVEDWGKGEDRREKGGWDDELYKHLPVGIREFMKHEKRMKEKHLREGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V937</accession>
    <name>A0ABR3V937_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000220">
        <property type="protein sequence ID" value="KAL1838349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="1">
        <location>
            <begin position="37"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="311" mass="35194" checksum="B58F78BB4597EC43" modified="2025-10-08" version="1">MHDSPLGLDAASQDLCQSLRQRTPPVPSDTLFRGDIFETTCAKLHGKNEPRVVQDIGRLIVPSAETLATFGEKHLDILVESVDEEWNNSIPLTHPHPQPDYSVGFKRGAFTEDQLAKLAPYIGNFFAGDQPYFMATYYMYFPFLTCEVKSSSTVLDVADRQNAHSMTLAVRGIVHLFHLAKREHEVNRQILGFSVSHDHRSVRIYGHYPEIVGQDTKYYRHLIHDFSFTPPNGENKWIAYRFTRNVYDTWVAEHFKRICSAIDQIPSDPSELNLDVSSPLVTTGISQQAGSMEGTEAPSGAYQVRTDYLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V971</accession>
    <name>A0ABR3V971_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="824" mass="89906" checksum="F8409E3A9F6F85C4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9P2</accession>
    <name>A0ABR3V9P2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000207">
        <property type="protein sequence ID" value="KAL1838559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23696" checksum="E4EF0DE8D9FC0CCB" modified="2025-10-08" version="1">MEIQINGGSVAEKVDFGHALFEKPVSIDTIFEKDEMIDVIAVTKGHGFEGVTARWGTKKLPRKTHKGLRKVACIGAWHPSHVQWTVARAGQRGYHHRTSVNHKIYRIGKGDADDNAATEVDVTKKKITPMGGFVRYGEVNNDYVMVKGSVPGVKKRIMTLRKTLFPQTSRRALEKVELKWIDTSSEFGHGAFQTPAEKKQIQGTLKKDLAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9T4</accession>
    <name>A0ABR3V9T4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000205">
        <property type="protein sequence ID" value="KAL1838599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="46530" checksum="6081AA6F1D9B99CE" modified="2025-10-08" version="1">MTSSLAIGTSFVITKKGLMQAEERHGFEGDGFVYLRSPLWWAGIICLVCGEVFNFAAYAFAPAILVTPLGALSVLIGAVLGAYFLKEELGILGKLGSAMCLIGAVIIVLHAPPDEDIQTIDEILNYAIQPGFLLYSLAVCGFAGFMIYKISPKYGKKNPLVYLSICSTVGSISVMAVKAFGIALKLTFGGNNQFTHPSTYVFMIITVVCILTQMNYFNKALSQFPTNIVNPLYYVTFTTATIVASFIFFRGFNTTDIVNILSLLCGFLVTFTGVYLLNLSRTDPDGTRTLARRTHGDMTGTDMVSSIQTRMSMEARRSLSHRRISTGSARAGDREGLMRSYDEEAAAGFGLTDLTEDTDEEESQDDPRSPMIPAFPKPNGHHPPKSPRGPAGGPSSSRSSSAGAANGNRLAVKGKNGGESIELQNQRLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA13</accession>
    <name>A0ABR3VA13_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000207">
        <property type="protein sequence ID" value="KAL1838564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="150"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="644" mass="70032" checksum="8814B19C10F01412" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA30</accession>
    <name>A0ABR3VA30_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="67"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="292" mass="32915" checksum="F04980CDCDF21051" modified="2025-10-08" version="1">MIAINGLPGTMIVCEEEVSKGYYELIIDSPDGGRPLREFDPADEADGHADRDPQMFDLLWFPNENKLPYVVKYVEAPAGSEFTIKITKAGQFRQQGHHLACRVYIDGTRNRDGFIEITNILTGDRTIGYKEHRFCFAKLGVVITAENKDLAVQNNMLKDLGVIKIEVYNMGCCTRDRSGLPMAVPAGAPMKVSEAVVKCTGVDCVTRYVTRNFTGKVSEIPTNVFNDRLQRPLAVFELWYRTKDGLMRERIVSRPTTESYQTRQDTKGLAAKTGYKERARQDGRTEIDLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA69</accession>
    <name>A0ABR3VA69_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000200">
        <property type="protein sequence ID" value="KAL1838677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="398" mass="42981" checksum="513F13AC21829E1F" modified="2025-10-08" version="1">MVLRLYVWGPAFGLPSLDAECLAAIAYLAQTLSAAEYQLIRSSPSAVPTQHLPTLHDPSTNTWITDYTAITAYLHARRYPSSQPRHHASAPRKLTTVQADRAAYTAFLTAHAAPLLALYLYVSSANYGGATRPAFSSVLPFPLPWTEPPAVRAAMSRRAAHLRLSSLDTDSAAVGETGGKDDSAIPGAAITRKSQTGVAGAMAPEQRSRIRLEALAAEVFNVLSSADWQEGQQPPEARCLAFAYLALMAVPVVPRPWLREILERRYRQLYRFVKDFQAETFPEGVEGLPWSQGDADGAGAVAARFARGVLVQVPGLGTLWRQWWTARKRRELRLETASGGGWLVLIGAGLGMTAVGVGVWFYRTLPPFGAAVQVWRRPVASGFGAAGLLLSGALYGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAN8</accession>
    <name>A0ABR3VAN8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000190">
        <property type="protein sequence ID" value="KAL1838842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="153" mass="16928" checksum="7E4B3E569164670D" modified="2025-10-08" version="1">MGYLLERLEGPDGHKDSVYSVAFSPNARELVSGSLDKTIKMWELNPSRQIGHTQQAPAKGGRCIKTFEGHRDFVLSVALTPDSEWVLSGSKDRGVQFWDPRTGHTQLMLQGHKNSVISVAPCPVPTPTGGYFATGSGDMKARIWSYTRLDRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAY6</accession>
    <name>A0ABR3VAY6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Origin recognition complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000187">
        <property type="protein sequence ID" value="KAL1838894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="10">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="9">
        <location>
            <begin position="372"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="56490" checksum="C1FD4B8447E74778" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB35</accession>
    <name>A0ABR3VB35_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000180">
        <property type="protein sequence ID" value="KAL1839015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="22"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="415" mass="45307" checksum="72B00B6DF169BBFB" modified="2025-10-08" version="1">MPSSLNLDEVRRSFPALAGNDVFLDNAAGSQVLGTVIEQIHDFLLHTNVQLGATYTASKKASDRYEQGYTAAARYIGADRDEIVLGPSTTQLFRNISFALDVSPGDELILSLADHEANITPWLDLASRHNLVVKWWTPNTTDPTNPKLLPSDLAPLLTPRTRLVACTHVSNLLGTIHDIRAICSAAHAHAPNALVCVDGVAYAPHRPVDVREMGLDLYGFSWYKLFGPHVAQVYASPRARKALRSLGHGFGKQKREEEMTLEEKVGLSGASYELVAAIPAVVEYLQGDQGGGGKWDAIVQHESELQRQLLSWLCARVDVTVLGERDGNPEERVSTVSFTVRGWGSKEVVARVEAESGGRMGIRAGSFYSGRLAEEVLGLDAVDGVARVSLVHYNTVDEVRQLVALLEKILNEQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBX0</accession>
    <name>A0ABR3VBX0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000188">
        <property type="protein sequence ID" value="KAL1838871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF8">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="378" mass="41031" checksum="CAFF6C4274383256" modified="2025-10-08" version="1">MDYTHTTYFPGAPPYQFMGGAQVPLTPSHSNSVASDDFSNRSPPVGVPPSLARFWPSRFPRHNGISANPIAGHEAYTIMTQEIFDQYPNVIPADQFQNFDSNYVHQYNASQAFPGPPTPPGQVPGHIPVHPATAAAAAAVVPAPVPAAVSAAIHQPAPAPDLLHVPKAEPEEQQQPGSRRQGSSEEEDLNPAQSRRKAQNRAAQRAFRERKERHVKDLESRLQQLEQVQQDTASENERLKRDLQKMETENEILRATSMAAVAASSGAAPVAAAAAPTTTGPMSYNPTDFYSNVLQGHANKTPSHRIVMSDKGERLLGPGATWDLITNHELFKNGRVDVSLVSERLRPQAKCDGQGPVFEESAIIAAIEQSVAENDELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC27</accession>
    <name>A0ABR3VC27_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000159">
        <property type="protein sequence ID" value="KAL1839399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="11"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="480" mass="54317" checksum="E927EC6D48A59D6C" modified="2025-10-08" version="1">MNARQSQRNVKWVEGLRGVTSVLVIVTHISRAFDFPLFWPADVKDGTPRLLQLPYLRIPWQGRIGVPIFAFLTGFVCAYKPLKLAYQQGNTSAALKSIARSAFRRPPRLMLPALIATFCSFVLSVLGGYKAANHCDSVWVRFDAPDPLPLLPNIGRFFTTSLTTWTNTENLFDRHQWAMRPLLIGAFQVYIVLAATIGMRFQYRVLVHVLLIAYWWMNVNYLTETFGAMLALGTLLAELAQHRPTQNWIMSHQRLLSCVVAPILMLIGGFVGSYPQENADWSPWSLHLHRFLTDPLGNGSVGSFINPKGSDTQRRTAAFFIMCWSITLFITPSLQRLLSHRLLIWLGHHSFAVYLVHGTILRTVGIWIAYGISGEPWEPAGVDENGKPKEQTWIAPRGRPYIMMSILVFVVLTYTAAWAWMRWVDSACARATQWLENKVFEEDNESAAAMAEKGYARVNGHDVTSRSPRYHDGDRSVPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC46</accession>
    <name>A0ABR3VC46_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000161">
        <property type="protein sequence ID" value="KAL1839375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="75792" checksum="439293094053EA59" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCE0</accession>
    <name>A0ABR3VCE0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000159">
        <property type="protein sequence ID" value="KAL1839406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="607" mass="66762" checksum="1E5F190769A55322" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCP3</accession>
    <name>A0ABR3VCP3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
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            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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        </location>
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        <location>
            <begin position="376"/>
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        </location>
    </feature>
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        <location>
            <begin position="205"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1839619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="450" mass="47204" checksum="260B71743905FD76" modified="2025-10-08" version="1">MMAWDSKPGRRRQSSAASGTRSIAVHARQQSRRLVQPRSQHVADPFLQDFLSPSFDAAAYLNATLPPLQTSSSSSASSKTPVGYTSGGSKPAVPLADVSTQAQALVTQLNAHTTRLTNTLTDLTNDILRSGGRLAYEVELLRGETVALADTLTDGLDADIAKFVPNGVRDTVLEPRTATDSHGVAPSHHQRRASILGPPPPPQPEQTTPPAGTTEPTVPDEPPYIAQLRTLTLVRARLDEVIKTFGDAMDFAFPPSEVSVTSSFLSVSAPAPPDTPTGGGGGGGGGSTSTGPSLEEKGQQTLQKLRDEITALLQPHSGSSSSSASDPIKGVEDAAKRVEQLKELASVWKGTAEEKGRAKFVDSLARMVEERHRELLKEIQQQQQQQQQQQQRGRSGSVKGQGEAAVAAGPGAKASAGGGSGADSDAAQTEKGYGGAYGLLSQLQKLRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="57" mass="6219" checksum="958848657836D366" modified="2025-10-08" version="1">MAPGQFDWFLSLGATPEAVAVLNDQPVLFTILLIPEQRAAKQKKKDAKNKKGPAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCY6</accession>
    <name>A0ABR3VCY6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_1903</name>
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    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000177">
        <property type="protein sequence ID" value="KAL1839073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06546">
        <property type="entry name" value="GH18_CTS3_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="1061"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="566"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="767"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="823"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="932"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="888"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1839073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1369" mass="144603" checksum="2525F7408F5F997A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD17</accession>
    <name>A0ABR3VD17_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000150">
        <property type="protein sequence ID" value="KAL1839578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07566">
        <property type="entry name" value="ScNTA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="879" mass="95211" checksum="F5F1C88617F926EF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD68</accession>
    <name>A0ABR3VD68_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="131"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="200" mass="20444" checksum="8D696DC59E11A7B1" modified="2025-10-08" version="1">MSLKYGVGGIGSTLAVVGAYMLFTGSGEAFNIGAFLESVSPYAWADLGISLCIGLSVVGAAWGIFITGSSILGGGVRAPRIRTKNLISIIFCEVVAIYGVIMAIVFSAKVNPLQGEAAYSADSYYTGYALFWAGITVGMCNLICGVAVGINGSGAALADAADPTLFVKMLVIEIFSSVLGLFGLIIGLLVANKATDFGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDC5</accession>
    <name>A0ABR3VDC5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="495" mass="53472" checksum="AEFDBDDA1D850940" modified="2025-10-08" version="1">MSYGDPPPAGFMGYMMPSSMGSETFEQDYLAVQMNTDPSDDSSSYPVDNTPYFFTLSGPLGMALDSAFPMAPSFPSHLAPATVPGTIEGSLPPGFTPEEDAAAPAPAPVAATATAVPGHPSRDQSAGLSGPAGSQSGGPALPDFTKRRNWPARIVEELQDLMIVLDANGRIRYASPSAEALTGHAPAELLGLLMKDLLHPDDVGVFTAEMNESIALGAPLRIFYRMRRRDDSYAVFEAMGHAHIADAGFAPNPANQTPFCQAVFLNARPYPTKNVALLDSFLEHKMENERLRRRIAELRGEEQEEVDESERAWQQQQQQQSHSAMPSNSSRAGTDSTTTVRPLMMASLGATYADRIELLTGLRYQEGERSRGITTGNPGAALITGNAGITIVPDQDARAGEKKKKQKVSEEHVCTDCGELSSLTHLVKRIELIVNAELLLHLGTLESPEWRKGPNGPKTLCNACGLRWAKREKKKSINQGPPVDLDLAMFVTDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDN3</accession>
    <name>A0ABR3VDN3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
            <orientation evidence="1 9">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000142">
        <property type="protein sequence ID" value="KAL1839740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="279" mass="32127" checksum="C21AB6171395215D" modified="2025-10-08" version="1">MAPTPSPPQTTPSEPPSSSSSSVPSSSSTPSDPTPQQQQQPPRFLKNDPARTGYDPSLKWWINYFKILTGQITPEGIEHYREDRYKVHEARDCARCERDRDYLFKYSPVIRFLRDKVQALNGELDETNVVCRRCPARVAEDGRVFRQGGGFSPDHGILICANEMRDRSHLEDTLAHEMVHAWDHLRWKVDWSGTGNLRHAACTEIRASMLSGECRWTRETMIRGNWTLTQQFQNCVRSRAIQSVMARPACRDREHATKVVNEVWDSCFADTRPFDEVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDZ1</accession>
    <name>A0ABR3VDZ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000155">
        <property type="protein sequence ID" value="KAL1839463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="107"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="346" mass="37822" checksum="B611E4F17EE8F011" modified="2025-10-08" version="1">MCVSSTFSKKAPRIATLGGDVEIAVGDNFLSGLGFDDGTTALALAYTTVAGQNITRSALREFRRNVLDRDDVFQAGFCTNLIFVGAKATDFEIAPDAFDELAVWQPSKSRPLDGARISVKDNIDIAGHKTTLCNRAWTELYPVKTKTAACVQTLIDAGAIVLGKVKCQAMTVREEPLECVEFTAPFNPRADGYQVPSGSSSGSAAGIASYDWLNFSIGTDTGFPQWVFSIRPSTGVLDRDGVVGYFPEFDMPVFFGRDITRLSDFISVWNVLRSCNYPQDYLPTENPAQTRLIDNFVTGFEKVLGVERTLISLAEAWKQDLPDGPGHADIGTYLETAGIYPFYHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEH6</accession>
    <name>A0ABR3VEH6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="577" mass="63258" checksum="4471304C2CAF8ADF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEU4</accession>
    <name>A0ABR3VEU4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_761</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000125">
        <property type="protein sequence ID" value="KAL1840145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="29"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="18">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="295"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="414"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1840145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="600" mass="66514" checksum="E7C342F102CE93D1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEZ1</accession>
    <name>A0ABR3VEZ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">VTJ49DRAFT_720</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000123">
        <property type="protein sequence ID" value="KAL1840190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 21" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 21" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 21" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 21" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 21" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16 21" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="22">
        <location>
            <begin position="510"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAL1840190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="591" mass="66593" checksum="F291CF92D23FC16B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEZ4</accession>
    <name>A0ABR3VEZ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000114">
        <property type="protein sequence ID" value="KAL1840428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27306" checksum="86BB8F555A8E4221" modified="2025-10-08" version="1">MMTTMTKARLSFLSLPAEIRIMIYNLVLRRDLPIELGLFVGPDKWWKDALLVPGWALFYVNKQVSTEARHQFYSINTFAFGETVIPPDEEFYRESDYHGWIQNIGGNALSIRNIDYFLSAAVDQDTVTLPLLVQLGRLMPNVESLVLSYRLLRQDHCLIAIFIRLTPQSRIELTILSLSWQYTPNLKGLTIVCATNSLAEKGAETRKRDALVLHDQVREVLQTRIFRRLEAVDFFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF44</accession>
    <name>A0ABR3VF44_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="394" mass="41700" checksum="F2CC8284FFE7A45F" modified="2025-10-08" version="1">MSVESNTCGICKAQPRYSAQYHYTQDTPVVLRPSPAQPLGISCPPREYTRSPFPIIHTTILQSPIPYSKPFSPRHRPTNHPPKQITRIEPTQNRNRPPLPVPVPIERDRHGTQPGTHNSADQSSERLIQRRRKAAESGPGAAVDATHKEEREQRESGHVRGAEQRVGAVRQEGRAEQDHSDVQKGCDEGGEQEGEDRRLFVSGWLAIKHKLSIEINERTRVGGTGKQRTERKHTVTPFPTPPSAAAPAFLLPLGSLPGVAVPVFFPAPAPAPAVPSPPSPPLLPATGKHTSAYATCSAVVTGSVVAISATGSATRARKRARKSAACRAGRACRAARASCVCFVWTGRSGGCCFSSLGGGGDGACGCGGCGDLLDLARAAVAAAPLASVEGMADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF80</accession>
    <name>A0ABR3VF80_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metallothionein-I gene transcription activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9122" checksum="90466D4AE0D317CD" modified="2025-10-08" version="1">MSREEYQVPNTGSGNSPAIGGGSFNATQRDFAGESGGGIIYYICGDCAVRVPLERDTPIRCQKCGARVLYKERTKRMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFJ4</accession>
    <name>A0ABR3VFJ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="2">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_839</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000129">
        <property type="protein sequence ID" value="KAL1840063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="871"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="15">
        <location>
            <begin position="93"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="14">
        <location>
            <begin position="238"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1840063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1095" mass="113934" checksum="19CABC3F0F313ABC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFL4</accession>
    <name>A0ABR3VFL4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41211" checksum="2C7A8B78675D1BA0" modified="2025-10-08" version="1">MTSPFPKSSSVGGEGLIVAALLPQGHSGLEAMTFQYPLKLITAMRPPETKSALVFLLTYGGGLVGGDRVSLAIEVRPGARLSLATQGHTKIFKSPSPDVVTRQLMRVDVATGGALCLLPDPVQPFAESVYNQVQIFRMARGASLCLLDWVTQGRRAFGEDWSFVRWTGRNEVWLAEGSEEDDKKKKKKTENEDGPGMVEKGDRLLVRDSVVLDSRGAHPQFPSLRETMHGLAVTGTLVLRGPLVKALGDFFLAEFAALPRLGARDWRSDSEAKLKQQETLAPKEQWRAERLRMEKEHRVLWSAASVRGCVVVKFAAPDFEAGRRWIGSMLAEEGSIAQHFGEQALMCVRIKSEPNSLDCLGGMKEGQASLHRSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFQ5</accession>
    <name>A0ABR3VFQ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59833" checksum="CDC12F9AB39C08DA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGE8</accession>
    <name>A0ABR3VGE8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000110">
        <property type="protein sequence ID" value="KAL1840506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="477" mass="55249" checksum="A47127D626F99C44" modified="2025-10-08" version="1">MSRWDPDRDRYEYDRERILEKERERDDDRYARRYPHFDDDDRSDHVLRESERRHVVYRGSSPGPIRRRAPSPPGRSQADDEVERSRVTFERERYRSPSPAPLRRRARSPPAEMERSRVTVEKERHRSRSPPPRLIRRQSSLDTFDRHPPRRYLDPEDRAYSPPPLTPAPGLATRRERIEHRDRFRDPRVSPYTYADPPPPRPPAPPAPVMSGGLHPVFRDARDRDREYYGEMQLANKERYEEDELHAYARRVRDEQLGRTTVETVRRTRSRSRERTSVRRRERSSSSSSRSSSSSSSSGESEGRSSVLERKDEYPKKGKTKIPRKMVSKRALRELGYPFVEEGNTIIVQLALGQQNIEDLVKLSAEYKKINEPTTIRYHSSTVGGHVLAEVDRSERRTEVYDHSPAYYDRPQIITSGPPVPYTPPTTITTTSSSGTGPIIIQTGPPPPPPRPSPFPVLAINIIFVDHQSSNTAQRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGJ1</accession>
    <name>A0ABR3VGJ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000102">
        <property type="protein sequence ID" value="KAL1840715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="174"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="298" mass="32302" checksum="B0E1EA8A131CE405" modified="2025-10-08" version="1">MLQRSTSSSHHQMTSRRDANNEDDDYDDIPLQHQRPFGTGLHKKPIAFVSASSLSTVTQTQPTATKPTTGASIADLYLSMVLPDDTATTTTSRSKSAPPSTTPTTDTTTTTTPSESTPSTITSQPTISEPSQLCPICNLPLPPSDDPAGLAAHNASLAHQLCLPYSPPPSALDRTRMGLTYLSAHGWDPDARRGLGAEEQGIQFPLKPRAREERLGLGAPAPARKSKEQGKNGEEAKQGKLLDAKKVRKMAVEDRKRREEIREELFGDGRLEKYLGVGRVVQSAPGSRAGERRRWLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGT8</accession>
    <name>A0ABR3VGT8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="526"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="4">
        <location>
            <begin position="746"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1156"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1158"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1186" mass="131223" checksum="8F8BB45F42665383" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGZ8</accession>
    <name>A0ABR3VGZ8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000107">
        <property type="protein sequence ID" value="KAL1840573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="517" mass="59154" checksum="57E54F76FC3EC512" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH15</accession>
    <name>A0ABR3VH15_HUMIN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="272" mass="31264" checksum="D22DB885FC3EA6E1" modified="2025-10-08" version="1">MDFFTFSSSKSSASSDVLPDHLQPEQQVLPSNSVEVTPPRDGFLDYGVLITTCVDGDTTTLRTPPFLPKYGPGGSWAVVSKDDVTRKEYSKKWRPMTPQKAFIRVRSQYVIARCTLWETARLSNPSLSNALKHRLKSPSSPTPVRLTADQRELDEALFHGDQALQKAYPRVDEKEYFRSREQSTSVEEEMDKDLDRIKRELLRCEMQFRDRIIYKLRECMVNKKPINYKKVLAEFSQGHNEVMKICGELQAAYKAGLERTKKTIMTCQKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH79</accession>
    <name>A0ABR3VH79_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="306" mass="32761" checksum="A350CC9BFACC5D36" modified="2025-10-08" version="1">MLPTPSTSHVPYSRVYEPAEDSFLLLDTFSQDSETSFLSTRFPAGSSPTPLLLEVGPGSGVVLAFLTAHAATLLGRSDVLTLGVDVNWFACEAASETVRRTVGEVEAEAEGVAGQVDVGNGSGEKGVKPRKSQRRSGHLLATAQGDLASPLRPGAVDVLVFNPPYVPTDELPTLPKELADPTTATTTTTTTTTTTTTTTSNDSEKKKPVPKTTYAQESTLLALAYAGGRDGMEVTDRLLASLPEILSERGVAYVLLCAQNRPEEVKARVRAWESERGRWMAETVGSSGKKAGWERLQVVRIWREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHF1</accession>
    <name>A0ABR3VHF1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="477"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="669"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="814"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1212"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1307"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1414"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="834"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1175"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1265"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1352"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1426"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1444"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1459"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1565" mass="168993" checksum="E3F8D2408761B311" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHQ8</accession>
    <name>A0ABR3VHQ8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="157" mass="17722" checksum="1C64545CC4B38A13" modified="2025-10-08" version="1">MPLLTSNDAEEELTPYDEDEDLEELERAERERDELLTQHWLACLAAANQKVTFPLVIDDPIEPDILAVLGPAAQGQKVDRVSRFGYDVLGTATIAMVTRCELGKVEDHYRLKGQEMETWMVVVDGVERIAYVPPSEAARASTSRPLRLPPYHCFPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHT1</accession>
    <name>A0ABR3VHT1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="519" mass="57788" checksum="8A3EACD7EE0EFBBA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHZ3</accession>
    <name>A0ABR3VHZ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SNARE-complex protein Syntaxin-18 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7341</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15850">
        <property type="entry name" value="SNARE_syntaxin18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SNARE-complex protein Syntaxin-18 N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="356" mass="39571" checksum="292587875536E6BB" modified="2025-10-08" version="1">MANLTTEFNSLLKGREAKPTKPFALETADEFLKEAYRINSDIARLHNDLRNLRQAYLSTAAPRKTHLRTAASSQYVTLTDRDREQIDAHAKMTLRDLNARIRALEDAEQLRQSTEAALLRSRLSRGLGILGSWAAGDGMRSEQAGLEAAARQLGAHRESVVWYLRTRLQEATRTQQHMMETRLTREMEKNRSVLAKARGPMAGVSVHGHDMVNGGIGKPRSAAEIPSGGGSLPLPEEEEKKRRATAVDNLTDDQRQMFEKGNQDMLKHLESTLDKVRTAERSLLEIAELQNMLVSNLATQSAHIDQLVADSFETTEGIGKGNKELKKSTSRASPARFTFFAAAGLCTVLVLWDLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI12</accession>
    <name>A0ABR3VI12_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="76" mass="8709" checksum="49359A916695FDC2" modified="2025-10-08" version="1">MCEKWVEEYHGCGHVLHQASQMPSHTEQDDLVIVGEPVTIDETQKKDTKESKETKESKDTKNTKDPKDPKDPKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIE1</accession>
    <name>A0ABR3VIE1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="364" mass="39354" checksum="C307C085F94592F8" modified="2025-10-08" version="1">MTTPTPSMLAAIQSCSLLDDVFREDSTTLELERRCAALTGKEAGLFVLSGTMGNQVALRSLLTQPPHSVLCDHRSHIVNYEAGGVAAMTGALVTTVVPSNGMYLTLDDIRDKVVLDDDVHSCPTRVISLENTLNGMVMPLEEARRISAFAREHEIKLHCDGARLWEAAASGAGSLIDYAACFDTVSLCFSKGLGAPIGSIVVGSNEVIKHARWIRKSIGGGLRQAGVVTAAARVAVDETFGTGPNGEGGLLRNTHTLAKEVAEMWTSAGGKLAFPVHTNMVWIDLDDACCPPERFEELGREHGLNLMDNRLVIHYQIYQNRASVLPKLKSVFTAVFEDKKRTATDSAEASQDRVGRASMYRTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIG1</accession>
    <name>A0ABR3VIG1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glyoxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="66"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="158"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40490" checksum="05DBB6A10078313A" modified="2025-10-08" version="1">MNCGFRMRPPAMSQGVWPIDEAISSIGMPHGPWEATYWAEPKVLLLEDIKHAHSSWATIESLADVISPTSSCRQDFLAEAASGAFDGCVAVYRTWESIVITGKFDAEVLDTLPSSIRFISHKGAGYDQVDVAACTARGIQVSNTPGTVDDGTANLGIFLLLGALRNLPVCMAALRDGKWRGTSEPALGHDPEGKVLGILGMGGIGRNMARKARAFGMKIRYHNRARLDRDTEKELEAEYVGFDELLAGCDALSLNLPLTESTRHIISKRELSKMKKGVVIVNTARGAIMDEAALVEALDSGQVSSVGLDVFESEPQIHPRLLNNPRVLLTPHLGTWTVETQEKMEELAIKNLHMFLTKGKPCTVVPEQRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VII9</accession>
    <name>A0ABR3VII9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000080">
        <property type="protein sequence ID" value="KAL1841286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="266" mass="28632" checksum="E05700148D293DE0" modified="2025-10-08" version="1">MAARVLLQRRAAPLTAAMLVGTVAFYPRTSHAEAPSSDRQLARKPIYDDDFDALPPPPKSEPTLPPSTEAPTPTLPSSSPSSPTSDLPSLPSTHGPTPTDRLAAQIRRARLFAYSQACIAEDAVNDVMSRAFALEQSFTSTLASLAPPRESGERLMPGLVYVLVAGMAGSIVARRRGIMLRGVTPLAFGLGAAWTVIPITMGNVAALTWEYEKKVPAVAEAHLKAREEVENAVRLAKVHAELAQQKVHDGVRSAREKLEEWVKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIT1</accession>
    <name>A0ABR3VIT1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="524" mass="58093" checksum="9C4F0790B8DD665C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ73</accession>
    <name>A0ABR3VJ73_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (fumarate)</fullName>
            <ecNumber evidence="11">1.3.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7582</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="366" mass="37941" checksum="B48E6EF0025F56B0" modified="2025-10-08" version="1">MAKTPPLFDINPPLINSACPWATTLDDLRRLYACPSTGAVTTRTSMIHGFDHDPAKHQFVFFDAARAAAHASSSSPNASVNSLGYSPLPLATYLDFVQTISNELPASQPATKGFIVSVTGSPEDVAASYTLLATAAPRLRFPLAMEINLSCPNIPGRPPPAYERDALETYLAPLRRAIAEAHAADDATPIPVGLKTPPYTYATQFLALLDALEGATQAAAVSAAAAAAADGGGEERGVCPVSFITATNTLGNCLLFAFPDPSSSTDAIVPALPRGPDTSLGTGGMAGAPLHPLALGNVATLRWLLDERARVLGRRLAVVGVGGVADAAGYRRMREAGADVVGLATGLGLRGVEVFGEVEAGLEGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJA9</accession>
    <name>A0ABR3VJA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_7020</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046302958" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1841465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="345" mass="37239" checksum="B1DCDEB2849B9AAA" modified="2025-10-08" version="1">MPPRWLSPLLTLLAVSLPGTLSHSHLAHILINGELYHGFDPRPDIVNHPGRVGWSNDATDDGFVPPANYSTPDIICHRGGASPRAHAPVAAGEKVLVQWNGWPVGHVGPILTYLAPCGGLAGDEEGCTGVDKTELRWTKIDDSRPAFQMLPGGQRVPGRGTFPPGQYWATDMLVAANNSWTVVVPRAVKPGPYVLRQEIIALHYAGKPNGAQNYPVCVNLWVEPPKEEPEGVFELDRHDAREFYREDDPGVLIDVMKMVAPTATYVVPGPTVARGATQLPHRQQVRSATWSPGTPVAVTKGTETVTMEMPATATGTRGAVSTTGPPTATPVVTRRWKGRFESDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJH7</accession>
    <name>A0ABR3VJH7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="432"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="800" mass="87230" checksum="8377796858A23E93" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJV0</accession>
    <name>A0ABR3VJV0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000053">
        <property type="protein sequence ID" value="KAL1842112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048955">
        <property type="entry name" value="Cip1-like_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21340">
        <property type="entry name" value="Polysacc_lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046108219" description="CBM1 domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="7">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="402" mass="42610" checksum="B72C52BD2D8E4BE3" modified="2025-10-08" version="1">MVRQAALAALAFLPLSLGQVTVSEDFEGGWDQSSWPTYAPDCSQGGRVSLDSSTAHSGSNSVRVDGAGGYCGHMFFGTKNVPSGDIYVRTWLKASRAFTDAHVTFITMPDPAQGTNKHLRIGGQNKILMYNREVDDATLPDLSPQGVAASAPLPANQWVCFEYHLGADGSIETWLNGNAISGLTVGPGVSNPNGGQWQRSSIKPRPTAVYFGWESYGGDSNTFWYDDIAIGSSRIGCESGGDNQPPAATTPGSPSTTSAGVTTTFLTTTTPAPNEPTQTKYGQCGGNGYAGPTRCAEGSSCSLINEWYSQCLFMSTVNVVIVQAGHHIATVQLETKQFRRARRTHALDIAVPAVILGFFVLAGSEADKGESTGTLGMARVLFITSPHGFKAYDGLRADVFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKJ7</accession>
    <name>A0ABR3VKJ7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="408" mass="42482" checksum="BE8BC6E23C3DA9D2" modified="2025-10-08" version="1">MWNPRSKNADKDDMTMKKNRGNTNFDRDLVDDFGKGNRFLSNMLFCFVVGLALVAMHPLSFGSVNTLGVMAAEVDVPSVTPVFSHVVDIALASSSDTPCTLSATTTYPTPSAPRGRMAALDGRNTESFTSWDVTAWSVGTGTAGTGAFSTGVFSTGTFNSSTLSCSAPEIVTVTVTRNDSHATTVDHGNSTKIWTTIYATLTETSTVISTTISTVAIPPFPTETETSTTSTSHSGHKTTVWETVFTTVTSHLHSFPADSATNTAEPHYHTVTTTLTITARNSTSTTTTTVDPSPFIGVTGTGNANKNNATSTYLLPSSSFEGHVPPPPPTSSVLASSGNSLFQWARRSPLAGTACGYAVGSVAGFVEEAAGVGGGAAGGGRNGENQRGGTGGLYCIVMVVMWALILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKP5</accession>
    <name>A0ABR3VKP5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="80229" checksum="2C25BB8428377AD1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKQ5</accession>
    <name>A0ABR3VKQ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_6283</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1841960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="442" mass="46606" checksum="BA0626AB0712C3FE" modified="2025-10-08" version="1">MASPPKPWERQGAAPATPSSLASTPTTVSSTTTATMPSTATTTATSVTSGASPAIPARPATLTATVNQNAAAYSRPYGATPYGASPYGTYGSAYSSPYGSPYSRLGAYGGGMYGGGMYGGYGGGMYGSGMYGAGMYGGMAGDPNNPESLTQRFNMSTAATFQMLEGIVGAFGGFAQMLESTYMATHSSFFAMVSVAEQFGNLRDALGSVLGIFTLMRWIRTLIAKITGRPVPVDAKSLNPASFSRFEGRSMPEGSGPPKPSRKPLLFFLLAAFGLPYVMSKMIRSLAANAEEERRRQLVTAQQTVDPSQLEFCRVLYDFSPSTQGQAVVQGVDLEVRKGDLVAVLSKSDPLGNPSEWWKCRARDGRIGYLPSTFLEVMRKPALAGRPVAAIKDAASDSSRTNSLTSTVSAPSTLPVQNPPPLPATKVGDLTVDSFQKTHFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL93</accession>
    <name>A0ABR3VL93_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="229" mass="26017" checksum="23F7FDA2870233D9" modified="2025-10-08" version="1">MDIRLLRASDIPLIQHANLENLPENYFLKYYLYHALSWPQLSYVAVDVSRPPKTPYDYPKIVGYVLAKMEEEPADGVQHGHITSLSVMRTHRRLGIAEKLMRQSPELAMVETFGAHYVSLHVRVSNKAAIHLYRDTLGFKTEKTESKYYADGEDAYCMRLDLGFLREQIREAEEEEKEKKTTTEGNGTEDVDEGEPVGDVGRDPAAAKSEQKIKVKVGRALGVGTHFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLQ6</accession>
    <name>A0ABR3VLQ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="13">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_6508</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="13"/>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="897"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="957"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="15">
        <location>
            <begin position="240"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="450"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="791"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1841831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1028" mass="113631" checksum="307E9872DABC99D5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLW5</accession>
    <name>A0ABR3VLW5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7165"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23749">
        <property type="entry name" value="DUF7165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="678"/>
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    </feature>
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        </location>
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        <location>
            <begin position="1245"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1322"/>
        </location>
    </feature>
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        <location>
            <begin position="1337"/>
            <end position="1346"/>
        </location>
    </feature>
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        <location>
            <begin position="1348"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1915" mass="204210" checksum="F1A1426F0B4333A7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLX8</accession>
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        <recommendedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF23">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G05900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="3">
        <location>
            <begin position="330"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="510" mass="56004" checksum="46A0BE88E5916CA7" modified="2025-10-08" version="1">MEIWGDSAHTAARISARISARSQPGESPQTRSMDGTTAPPPRAGPASVMDATGVFMVAVTILAFFLPLLLYFPPLPPSQRDALLETHVQVGVAPANSALRSANRKRADAARNAEKESKSSSSSSNTTTTTTTTTTIRSLWIYPIKSCRGIELRQSKVLATGLEFDRLYTLAQRKSSTSSASSTADSQDGAPDWHFITQRQFPLLATVSVDLFVPDVVKARGNPSSASAQSFLLVRFPWRAPGLRGAAAWLAAKLTRGWSAQPEMEFVLPAAFPENPEDVAARGYRRATVAIWKDVVEALDMSSELPPELGQYLGVPGPLALLRVDPARLRTVRRCAPTATDAGYQPVTGFQDAYPLHMLNLTSVRDFEAKIEKDDDFRELDPRRFRANIIVDGGETPYDEETWKKIRFLPAPGSTRAPSTFHVSCRTVRCKLPNVDPDTGLRHKAEPDRALRKYREVDEGAPHKGCMGMQMTPLFPGTSSSTKAEDLESWVEVGMPVEVLERGDHRYIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMI4</accession>
    <name>A0ABR3VMI4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3052</name>
        <name evidence="10" type="ORF">VTJ49DRAFT_674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="492" mass="53634" checksum="24CFE689E0C654E2" modified="2025-10-08" version="1">MVFKGLSKASRRLHYFCLVLALGSFVWGYNIGVLASVLVHPGFKSTLNEPTARRSGLITAIYYLGAWVSYVFVTHPLADRLGRRKAAFTGMSIMCAGQALQAGAFGPHALAMVLAGRVVAGLGTAVVSTSVPLYQSEVAPPRERGRYVVMNHVGFVAGLASGFWFGYAMTFWDSDRGLTVAWRFSLGASFIPALLFLAALPFMHESPRWLVEHGHTDLALSTLHFYREGYYTPEEIEAELSDIERSVAVFRISGLTWVSLFSDPSLRARMWRAALLQFMAHMCGATAMKYYLPALFKALGFSHRVSLLAGGIESTLKTGCTVVEMLIIDKVGRRITLIAGAVIMAFALMVNGALPLAYPNNVNRVADFTCVVFIFVYALGFSLGFGPSAWVYGSEIFPTAVRARGLSFAASCGALGSIIVAQVWPVGIASLGSKIYFVFMVVNLAAVPIIYLFYPETKGRPLEDMDRLFSGSPGSSSENLLADREELDQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNP0</accession>
    <name>A0ABR3VNP0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF273">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN SAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="228"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="503" mass="56287" checksum="B44A85B66A6FD16B" modified="2025-10-08" version="1">MGTTPLEEPSLDTLLERRQQLTDALSESPYDLILYLERAVVYSSLAYPDLAASDAYRALLLADEVRDEGFEYHEEAKEALESYSEIRPCPEVLNHGRLVEELNLPSAEEESDDESRCEALADLASVRSFQILAKSLLLVGCLRSALEFCERGLAKLPHNTELNETKASIEQAARKRLGLRDDEPVEVQDLPDRGLVRREVYPWNTYEPDRFSDESLAFLNKLLAEVAPKVEVRVSRLPVLVANDGESGTNPDSKEEHGEIPMCNQLGLFAKEPISPGEVVLDEYSLLTANNRHKESACDACGTELSAADVSQAVSCPECDDTIFCDETCLNAALEQYHPAVCDMDVDSIAKDPEAKDVDESLYLLLLARLLAMAAHQGVHPLEVKEVKYIWGDFLPTPLSQTDPTLPFTFTHTLQLPLHLLERMDINIYTTLPSHDQWILNTCLAKFRGTASARKNPRDGRPDLAAVHPLWCLANHDCDPNVTWRWEGGTQNYNLLTERARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNQ7</accession>
    <name>A0ABR3VNQ7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="388" mass="42775" checksum="C1C2A1EAE5F33599" modified="2025-10-08" version="1">MDATPRHPLFLSPKPPSDLVQFIIDRCTYPTVLLICSSRADFLSALTQDIVSRQQREQLHHRQRQHEQPPPTTEEVNETADLSHSKDGVPEGEDDRQEIGDGVDEEVYMDDDDEDAAEPSTSLHSISSNSSSSSRDIFPHHPPYPPHLQSQSHPLLTPTLAQLSTTRHIRTVFVPTVSHLRAFLSDFSLVDDKAAAFLSSTHHKPPPRNFPPLPPPPPPPPPQHQQPNTHHRHLSTEPRKPLEKNPLLLVYDFLALHRHTSEWSAQGIGASAAGLVEAAARTGLRAVVVEGRQRPQEQGQGQGVQTFGQDGGDGEEEAAAAGIGEGDGEKPALEMMSMEELLAEKVPILSGGNAKRVGGELGRKTVEVRVVLGRWFRFRDGAWWDGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNR9</accession>
    <name>A0ABR3VNR9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1067"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1105"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1137"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1170"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="664"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1230" mass="137259" checksum="4CF87B5086876FC1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNW4</accession>
    <name>A0ABR3VNW4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="297" mass="31793" checksum="EF50FA04F6D952DE" modified="2025-10-08" version="1">MDPYSAEGELINIHNHFHQGQYQEVVDFDVSSLSPENALPAQVLQLRARIALGQAEDVLAEVKGAAEPELIAVRALALRALGRDEEAVKTVEDLLAGNADAADNATVQVVAGTVLQAAGNSEEALALLGRHQGSLDAVALIVQIHLQQNRNDLAVKEVAAARRWAQDSLLVNLAESWVGLRLGGERYQQAFYVFEELAQAPATSSVRSLVAQAVAELHLGRTEEAQAALDQALKKEPGYAEAIANLLVLSVITGNGVDELTASLRKADEKHPFLVDLAEKSELFDKAATKFKAKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP33</accession>
    <name>A0ABR3VP33_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_374</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="20">
        <location>
            <begin position="128"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="184"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="520"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="751"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="860"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1843674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="930" mass="103828" checksum="4ED95F54EB0D5242" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPF9</accession>
    <name>A0ABR3VPF9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_7505</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="16">
        <location>
            <begin position="1002"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="441"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1241"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1843795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1277" mass="141184" checksum="85561A8BA7E26CB3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPX2</accession>
    <name>A0ABR3VPX2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045831434" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="45"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="364" mass="39861" checksum="26E199DFDF73E416" modified="2025-10-08" version="1">MRLSSKSAMLALSATLVDAAPQFGGIFQMTMLRFGCTNIVIDRIDPLVNPGQVPSPHVHQIVGGNAFNVTMPTGDVAQHADCTTCSFADDFSNYWTANLYFRARNGSFKRVPQGGHAFQFNDRYSTQTQGGILVYYVSDQPGRVTAFKPGFRMLVGDPNMRSRPDTRLKRQNCYRCYTGPNFGGDTGAPCMDDRVDTEALPNRVCPGGIRSNILFPTCWDGKNLDTPNHQDHVAYPVSGPTDFLGTSGACPSSHPVKIPQLMYEVVWDTTPFNNRAEWPADGSQPFVLSTGDPTGLGQHGDYVFGWKDDTLQRAMDTAGCFGAQCANLRTQSIEVGRQCAVKRAAHEDIDGWLDELPGVGKMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPX3</accession>
    <name>A0ABR3VPX3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3,2-trans-enoyl-CoA isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29674" checksum="F77B6AA57678A4B5" modified="2025-10-08" version="1">MASPIKIEYRGRVAVVTIDNPKKLGALDSAGYYDLAQALREIATHDEVYITLLIGTGRFFSAGADVTLSRDTPSTQTPAELRKALLASFVANNLNAANAFYTHPKILVVGLNGPVIGLSAALVSCADFIYAAPHTFLLTPFASLGLVAEGAASRALVQRLGPARANEALIMSKRITCEELLAAGFLNKVFTEVKEGEDEKFKQLVLREIDERLGEHLVGESLLGIKKLIRKPERDILDASNVAEVFAGWERFASGVPQEEFRKIATGQKRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ46</accession>
    <name>A0ABR3VQ46_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="267" mass="29269" checksum="39FA20BCD172A167" modified="2025-10-08" version="1">MASGYDRALSVFSPDGHVFQVEYAGEAVKRGTCAVGVKGKDVVVLGCEKRSAMKLQDTRITPSKIGLIDKHVCLAFAGLNADARILVDKARLEAQSHRLNLEDPVTIEYITKYVAGVQQRYTQSGGVRPFGISTLIVGFDKGSETPRLYQTEPSGIYSAWKANAIGRSSKTVREFLERNYKEDMDREATIRLAIKSLLEVVQTGAKNIEIAIMAPGKSVEMLPVEDIENYVKNIEQEKQEEAAKKKTGRTPGTGTAAILTRSAQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQZ5</accession>
    <name>A0ABR3VQZ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_8</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="320"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="627" mass="69673" checksum="7F39A8355E5E067F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR06</accession>
    <name>A0ABR3VR06_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19860" checksum="D8DAA378E139708F" modified="2025-10-08" version="1">MRGAGATWFARWGGPTYVKTQYGSFQTPADSSNATFVRIRGSQNPSVCVNMAEIGAKLQALSEEFTKLQQDLQEAVQSRQKLEAQKQENLGVQKQEFAKLKDDETIYKLVGPVLLKQERTDAESTVSGRLEFIDKEISRLEKHIKDLQGKMDKKKTEIIQIQSSAQAAAATAAAPQAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRB9</accession>
    <name>A0ABR3VRB9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045163580" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41123" checksum="FC2284CCFF13BBFA" modified="2025-10-08" version="1">MTLKNLVASALLAAAPAFAHPGHKDVAPHGPLYRRNLDHCAGKFQEPEFIKRTVEVHGAEIARLRRSLGIQEKAKISPRDYLSVSRIDHKSNKTVTKGMDLSTLFSDAGACMLTPTVDLGPLYVQGEEIRKDITNGERGVPLTLAIQVVDYRTCQVVPDAYVDIWSSNSTGIYVGVQGYPGMGDPNDASILQGTTLRGVQPTDSHGIASFDSLFPGHYDGRATHIHTVVYVGATRQPNNTITGGRAAQIGQIYFDQSLISAVESLPPYNTNRMPIVQNVNDFLFRMGANGDDPIMRYAYVNPNNLADGIFAWIRFGVDVNANKPINPAAFWTEKGGVMNPTGPVQPGGGFPGFPGFPGGGWPWPWGRRRAARAEAQNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRF8</accession>
    <name>A0ABR3VRF8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1844256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30910" checksum="B75F85DC1C4DB528" modified="2025-10-08" version="1">MENTIQVNDYRQMDKIIKEERMYLLNMVKKIKKAKCNVLFIQKSILRDAVNDLSLHFLQRLGILAVKDIERDEVEFICKSTGCKPIADIDSFTEDKLGSADLVEEVQSAGSRMVKVTGTKPSPQAGKTVSVVVRGANSLILDEAERSLHDALCVVRCLVKKKALIAGGGAAEIEIASQLSKRARELSGTEAICWKAFADAMEVIPTTLAENAGLNSIKVVTELRHRHELGEKNAGVSIKSAGVNSNIAKENVLQPLLVSTSAIELAAETVKMILRIDDIALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRU2</accession>
    <name>A0ABR3VRU2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_56</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="248"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="614"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="893"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1198"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1448"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1560"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1617"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1664"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1737"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1468"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1507"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1565"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1690"/>
            <end position="1701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1762" mass="190865" checksum="18FF567A04F7A8FB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0J0</accession>
    <name>A0ABR3V0J0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000742">
        <property type="protein sequence ID" value="KAL1835320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="261" mass="28025" checksum="DCC93D7D95354983" modified="2025-10-08" version="1">MSLLKNPDPELPSSPPLASRITTLIAAETSPSLLHRDADLPFNSQLHLERHVLPAPSPSADGGGDGEVPLPFETDSFDLVLSSLSLHWINDLPGMLGEINRVLKPDAPFIGAMLGGDTLFELRTSLQLAEQERRGGISPHVSPLADVRDVGGLLGRAGFQMLTVDVEDIVVDYPDSFALMQDLQAMGEGNAVLGREMGGLGRDVMLATDAIYRAMHGNEDGSVPATFRIIHMIGWKEGGNQPKPLPRGSGEVNLKDVLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1D1</accession>
    <name>A0ABR3V1D1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000594">
        <property type="protein sequence ID" value="KAL1835595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="137" mass="14663" checksum="83B2289612CD4A09" modified="2025-10-08" version="1">MPCARRSRKNSTAPARARQNSTASLTPALTRPREKKKPVTTEGPYDPFGGLEFTPSRYRVLPGVHTHPGIDKYKSDPAHVTGGYGFDDYTARAMFEAFAGLAVFVEDEKEVGVGLSAGEVATMSAGIAAVGDKMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1F5</accession>
    <name>A0ABR3V1F5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6491</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000608">
        <property type="protein sequence ID" value="KAL1835552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="217"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="835"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="12">
        <location>
            <begin position="980"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1835552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126795" checksum="1B2342EE3B1E7406" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2M9</accession>
    <name>A0ABR3V2M9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000525">
        <property type="protein sequence ID" value="KAL1835847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0518">Myosin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="207"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="370"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="520"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="875" mass="95474" checksum="B6ACEEB9BD7BB50C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2R3</accession>
    <name>A0ABR3V2R3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000517">
        <property type="protein sequence ID" value="KAL1835877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044983170" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="581" mass="64405" checksum="10A7BC2A1C6A8E11" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3F0</accession>
    <name>A0ABR3V3F0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000463">
        <property type="protein sequence ID" value="KAL1836117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59110" checksum="EFBE9174FD2DACF7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3G2</accession>
    <name>A0ABR3V3G2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000438">
        <property type="protein sequence ID" value="KAL1836270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="962"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1384"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="647"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1386"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1402"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1413"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1449"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1519"/>
            <end position="1530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1543" mass="164132" checksum="4FAB54FF71E8ABA9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3M8</accession>
    <name>A0ABR3V3M8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000422">
        <property type="protein sequence ID" value="KAL1836362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="626"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="642"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="850" mass="91299" checksum="16F2E5ACD104454D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3R3</accession>
    <name>A0ABR3V3R3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000413">
        <property type="protein sequence ID" value="KAL1836427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
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    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
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        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="211"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="521"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="702"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1347" mass="151478" checksum="8DF50A20CAA56AC3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3S6</accession>
    <name>A0ABR3V3S6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000440">
        <property type="protein sequence ID" value="KAL1836260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="77577" checksum="EDC1F4E0D4F57DF8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3T4</accession>
    <name>A0ABR3V3T4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000411">
        <property type="protein sequence ID" value="KAL1836438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="43"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="664"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="776"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="965"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1048" mass="115014" checksum="BE5C407780BCECE4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V416</accession>
    <name>A0ABR3V416_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000422">
        <property type="protein sequence ID" value="KAL1836365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="142"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="556" mass="60488" checksum="3FA895BCC7AECEEF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V454</accession>
    <name>A0ABR3V454_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000444">
        <property type="protein sequence ID" value="KAL1836231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53001" checksum="5FB7ED08A0C2FBFC" modified="2025-10-08" version="1">MTETFKPGSKRKAPDDEADPDLQDLRDPDPPQSFGGSRSSQPDPRRSGPPDPGVSADDYFRHLYDTEPDFAQLAKQDPDFKAVVQPNGQLDFTNPHATMQLTKTLLQADFGLKIDLPEDRLCPPVPNRHNYILWLKDLMDTTSYNPPGRPLCGLDVGTGASCIYPLLGTRQRPWTFVATDIDDKNLAYARRNIHLNNLSSRIHLLSRQPSDPLIPFDHPSIKTKTIDFVMMNPPFYSSPDEMLSSAQKKSRPPMSACTGAPVEMVCSGGELSHVGRLLRESLALRDRVQWYTTMLGKLSSLEALVEQLREAGIDNYAVTEFVQGSKTRRWALGWSFAPMRPAEHAARGMKAAIWKKLLPPATTTDLLQLPVDTPVEPVIARINDIGLGLASENVWSRAWRRKKLREQSQQGLDNNMQDPSPSQQPAECRLGFEIRVVMGKAKTSVSLHWREGHDPLLFESFGGFLSRKLKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4I1</accession>
    <name>A0ABR3V4I1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000452">
        <property type="protein sequence ID" value="KAL1836178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="956"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1169"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1182" mass="128374" checksum="48356AC76304029D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4S0</accession>
    <name>A0ABR3V4S0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_4712</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000370">
        <property type="protein sequence ID" value="KAL1836753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16658">
        <property type="entry name" value="RING-Ubox_UBE4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="1032"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1103"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="570"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1836753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1122" mass="125920" checksum="1E7FC03A83D6987B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Y7</accession>
    <name>A0ABR3V5Y7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000360">
        <property type="protein sequence ID" value="KAL1836836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021589">
        <property type="entry name" value="Cut12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11500">
        <property type="entry name" value="Cut12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="984" mass="106471" checksum="17B8C448C7B82B5F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V607</accession>
    <name>A0ABR3V607_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000319">
        <property type="protein sequence ID" value="KAL1837199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="208" mass="23306" checksum="AEB61ED8B02BBFA0" modified="2025-10-08" version="1">MNGSVNPEPRVLPSTKSLYIPQTLDRILSSQGIWRFRPSKLPRRLHRRLRRSSRCRAQQLPQCPLGQFCRGVQRLAVHVEPRAVDDELHVLGQVEDGGDQGEGGEEEDDRVCWPRGFRLAQSEALKRGSFVRGFGALGERKKGMGRRTKDELLGRCKHVDTVGDLELVDLELQPLAEGLESGGHGGRVGEVGFRITRWKRGKKVGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V669</accession>
    <name>A0ABR3V669_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000312">
        <property type="protein sequence ID" value="KAL1837263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047522759" evidence="2">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="206" mass="22597" checksum="59682BCF783B0FE6" modified="2025-10-08" version="1">MRIAVLVCLWKAAKAERQKGCKRDEGSPGREELRGVGYEREKGNGGRSVKVQHQAGVLTSFWGEAASALREATRQPIRDERPHKSPCPIGPIRVSPCGNSLLDLPKKLRASEGLLLPRGRDCELHLLRFGVFCETSTGLRKLLSATCPSLEASQPELEEMEHAQSSMEAEVWNPQTRSRGSWGWIPLAPTSRPCAALPQPAPEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6G0</accession>
    <name>A0ABR3V6G0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000318">
        <property type="protein sequence ID" value="KAL1837205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="156"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="551" mass="56131" checksum="FC1D384DE8B77983" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6H9</accession>
    <name>A0ABR3V6H9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OsmC family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000301">
        <property type="protein sequence ID" value="KAL1837368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20759" checksum="17E7501F556C4776" modified="2025-10-08" version="1">MTSTCLLLLRSLTRRQPRLSNPTRLFTTTPHRRLPSTTLPVTITATGTGTLQHISIPGKPYTFTSDTYPLLGGSDSAPSPVVYSLAALSACTQVTGHVVARDRGIKLGEWDVHVEGRLPTGTLVKGEEGDPNWEQVIMKIRVQTDVGNDEFGQFVYEVERRCPITALFRKSGMWYESVWVNERVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6J8</accession>
    <name>A0ABR3V6J8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Haloalkanoic acid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000300">
        <property type="protein sequence ID" value="KAL1837382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30362" checksum="DCFB54B70FE4E424" modified="2025-10-08" version="1">MSPHPDLTTFRALSFDCYGTLIDWEPALAKDLSPLVTHLDPSHPFRTNPLLAIQRFDEISMRLEAENPRMPYPENLSTSFHLLGKELGIDTTNDALTANATSVGHGPSRWPAFPDTVSALARLARRYRLVVLSNVDEASISRATAGPLAGEGFKGFDAIYTAEKIGSYKPDLANFRFLKEAVKKDLGMDAEKGELLHVARSLIADHVPAKEAGLRSVWIARGGDKPKGYGLGGDYERLKAEGKLGFEWMFQTLGEFADEVDRQFKEKARREKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6W7</accession>
    <name>A0ABR3V6W7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Centromere protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000286">
        <property type="protein sequence ID" value="KAL1837518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21096" checksum="9A80EDB9639257E4" modified="2025-10-08" version="1">MPPKATGPGRGGRVAASNNRTATSNKPTTNASRSTTAPRGRGDASTTTGGASRKRTIDDYAHGGRTNTVDEEEEEEEEPQQDEEELEAVEEEEEEEEEDDDREKIPPELLTRILHACFEREGTRITREADRAVGRYVDVFVREAIARAAVERGRGFLEVCFASLFFPFPVCVGGLLGSGLRLGRPGLDVVGSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7F1</accession>
    <name>A0ABR3V7F1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000269">
        <property type="protein sequence ID" value="KAL1837718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="352" mass="37428" checksum="EEDCC4053850288F" modified="2025-10-08" version="1">MSEQIPTEQWAQVVEKPGGPVTYKKIPVPTPGPDEVLINVKYSGVCHTDLHAMMGDWPLPTKIPLVGGHEGAGVVVAKGELVKDISVGDHAGIKWLNGSCLACSFCMQADEPLCPKALLSGYTVDGSFQQYAVAKAAHVARIPKDVDLEAVAPVLCAGITVYKGLKESGARPGQAVAVVGAGGGLGSMAIQYARAMGLRVVAIDGGEEKRQSCKALGADAYVDFQTSKDLVKEVKEATPEGQGPHAVLLLAVSEKPFQQATEYVRSRGTVVCIGLPAGAYLKAPVFDTVIRMITIKGSYVGNRQDTQEAIDFFQRGLVKVPYKTAGLSELQKVYDLMKEGKIVGRYVVDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7H5</accession>
    <name>A0ABR3V7H5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000336">
        <property type="protein sequence ID" value="KAL1837033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056026">
        <property type="entry name" value="DUF7607"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24580">
        <property type="entry name" value="DUF7607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="892"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="531"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="765"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1213"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1577"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1753"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1216"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1581"/>
            <end position="1591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1827" mass="204103" checksum="4E2FB2507D749B29" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7S3</accession>
    <name>A0ABR3V7S3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000259">
        <property type="protein sequence ID" value="KAL1837837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="253"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="480" mass="53303" checksum="0A54EBCDF164AB42" modified="2025-10-08" version="1">MDSIKFKRAEGRQLIKDKVVLILKSIAKFPIDAKITVIDGPEQADGWSCGFWGLERDRIFFQELWSRLQHNQKVLSFNLNQTRCYWKFGRESGEENHARQLSQFGSPPKWTSAALREEFPSLVVAMAPIKVAVLDDYQGISEPKFRALDPTKFEVSFFPDTLPPYNRPGTSQETRDQLTTPADPLPGTMRERTPFPAELIARLPNLRLLLTTGNRNLALDLDALRARGIPVAGAVDRAHAGSVGSVSTTEHCVALVLAAARNIAQDDLIIKSGGWQTAPAVSLRGKTLGLVGLGRLGTAVARILGGAFGMRVIAWSENLTQERADTAARDAGLLLSDGSGDGIRAVGKDELFRTADVVSLHLVLSDRTRGCVSRRELELMKPTAIFVNTSRGPLVVEEDLLDVLERGRIRAVALDVFDLEPLPLDSRWRTTKWGKDGRSQVVLTPHMGYVEEATLDAWYDQQVENLLRWDRGEELDLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V801</accession>
    <name>A0ABR3V801_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000317">
        <property type="protein sequence ID" value="KAL1837213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="197" mass="21069" checksum="4AA2723250403CD8" modified="2025-10-08" version="1">MATTATSAAEAAATTTSKGHGMGGHGCVISMLWNWNTVDACFISSTWKIRSAGMFAGSCIGVILLVMSLEMLRRAVKEYDRYLINKHLASQGQSRRPVSSSGKAASDEGSPAPVCVTVAGQGYRPALFEQAVRALLHMLQFAVAYFVMLLAMYYNGYIIICIFIGAYLGSFVFHWEPLGVGSSVQTSATKEATVCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V803</accession>
    <name>A0ABR3V803_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000255">
        <property type="protein sequence ID" value="KAL1837889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="403" mass="44280" checksum="FE04DF2C83D9E92C" modified="2025-10-08" version="1">MQIPSNLFLNKFGKPAIYLPACMIVWGIISALTAVCTNAGGLWANRFFLGIVEAAYFPGCLYYLSCWYTRKELGFRTAVMYSGALISGAFSGLIAAGVTWGMDGTRGLSAWQWLFIIEGATTVAIAIGCYFVLPNFPRTTKWLSEEERALAVWRLQEDIGEDDWVNSEEQTFWQGAKLAFTDVKTYILLVLLFCIVSSGTVTNFFPTVVNSIQGQLSDQNRQSNVITLLLTSPPYVLAVAATYLNATHADKTGERYWHITIPMWVAVVAYIIAATTTHIAPRYLSMMLMPPAVYSGFVVALAWISNTIPRPPAKRAAALAFINAVSNCSSIYASYLYPKSADPHYTVAMIVNCVTAFVAVCAATVMRIVLVQLNRRLDKGEWVEGAINAVPGEGAANGFRFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8F5</accession>
    <name>A0ABR3V8F5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000267">
        <property type="protein sequence ID" value="KAL1837731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045439966" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="163"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="630" mass="68596" checksum="06A9274B1DCB529D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8Q3</accession>
    <name>A0ABR3V8Q3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000230">
        <property type="protein sequence ID" value="KAL1838214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="75"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="583" mass="61109" checksum="87090C68257343EE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V979</accession>
    <name>A0ABR3V979_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione reductase</fullName>
            <ecNumber evidence="3 12">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_2834</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 12"/>
    <dbReference type="EMBL" id="JAZGSY010000224">
        <property type="protein sequence ID" value="KAL1838294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="9"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="359"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1838294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="472" mass="51178" checksum="94DD5DF91F056751" modified="2025-10-08" version="1">MAPISKETDLLVIGGGSGGLASARAASTRYGAKAMIIEGKRLGGTCVNVGCVPKKVTYNAASIAETIHQAKDYGFSVQETAPFDWTTFKKKRDAYVARLNGIYERNLANDKVEYVHGWARLISRNQVEVTLDDGTKTVVSAKKILIAVGGHPTPPPSIPGAEFGTDSDGFFDIDTLPRRVALVGAGYIAVEFAGMFNALGVETHLFIRYDTFLRHFDPMIQEGVTKEYERLGVHVHKRSEVSRVDKDPATGKLTLRYKHSSAEEKEEVLADVDHLIWAIGRTPLTAGLGLETAGVETDAKGYIKVDDYQNTNVENIYALGDVTGRVELTPVAIAAGRRLAARLYGPEQFRTAKLDYENIPSVVFAHPEVGAIGLTEPQAIEKYGKENVKVYKTSFAAMYFAMMDPADKGPTAYKLVCVGPEEKIVGLHIMGLGSGEMLQGFGVAVKMGATKADFDNCVAIHPTSAEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9S3</accession>
    <name>A0ABR3V9S3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2594</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000209">
        <property type="protein sequence ID" value="KAL1838520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="138"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="288"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="436"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="612"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="800"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="962"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1078"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1091"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1135" mass="126402" checksum="AE4C1512346808A6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA45</accession>
    <name>A0ABR3VA45_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000207">
        <property type="protein sequence ID" value="KAL1838567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305:SF24">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE C03B1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="660" mass="73030" checksum="4C738E71CB7E4286" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA77</accession>
    <name>A0ABR3VA77_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000213">
        <property type="protein sequence ID" value="KAL1838457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="475"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="600" mass="65370" checksum="87FA4E6894CBF8BA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAE9</accession>
    <name>A0ABR3VAE9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000238">
        <property type="protein sequence ID" value="KAL1838098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="203" mass="22219" checksum="B9DCD507A70589DD" modified="2025-10-08" version="1">MAGTETATQPLDPYKESNLDKEATLEHKVEDLSHFMKHCKFAMMTTRDAKTGLLMSRCMALAAQETGGIDLLFHTNTTSGKTDDLASDSHINIAFLTSHGEWASVSGKASVVTDRELVKKHYSDHLKAWLGDLGDGVRDGSANDPRLGVIRVKMITAHYSFSRKGPIGQLAEVAQGVITGKVATPNKLREISEAEVDQWRLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAH4</accession>
    <name>A0ABR3VAH4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000236">
        <property type="protein sequence ID" value="KAL1838128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046031403" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="156" mass="17853" checksum="2DD7AD1EB5ACED5A" modified="2025-10-08" version="1">MKLLPCVAALLVAPLSAVALPTGGVNLLAPRQWQQAPPPCVRQDPPPSQEETEARFREFVEVFVGPRKNLYEAFKYISADYINHNPMANDGHQAAWDVLSPFWNSFQHTYLRSTIQDNMSWVNYRAGFMGEVVDRFRWEGGCIVEHWDQGERYPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBD4</accession>
    <name>A0ABR3VBD4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="9">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000172">
        <property type="protein sequence ID" value="KAL1839154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="816"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="999" mass="108546" checksum="7757857AF6C129D8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC53</accession>
    <name>A0ABR3VC53_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000164">
        <property type="protein sequence ID" value="KAL1839316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047168756" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="53928" checksum="157F03C0B9781F56" modified="2025-10-08" version="1">MRPARHLYGLLLASSTSILVSAQQDSLGCTTRSFGIPSWLVQDVTRTDGVLTFDLVNRATNYTASLACEGAGAAEVKAGLYNCTVVQTSSSSAGEELDAAVEFTADSTKGATYHIKQSWRCDDRGQVLTFTALGTSTAPSPSYSSPLLIRASLTSPVSITPVYNDGPLGHDSPGCTSRSTTSPAWVLSAIHFADEPGDGVNFIPLQNFMVVVVNTATGYEASCNLGRRGLDENGMATLGCNGYEFQSSSVGAYPVSTRAWFDAERYQMGVEQTWFCDDEDAAKPLQITASGNTTLSLTCRSVTSEITGLVNRYCSSTASTVSVPGTLVQDPVTLAPYALEDPVLTASDHCTLTSILHPRWTFSHLALVGEKQEEVYFEVILEVDNRGFQYPIAVNQGEEVQGAEGWYECVIGDDGDNGLPLFPYWCQFKYERETKTLEMKAKWACNDLDRENLVHFSGSSTGTLDSEFSCDTLADGLVWCTTEDPGYRFTVPITDVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC55</accession>
    <name>A0ABR3VC55_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000166">
        <property type="protein sequence ID" value="KAL1839284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="69"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="658" mass="71169" checksum="502BA76CC7A8A1B5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCH0</accession>
    <name>A0ABR3VCH0_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">VTJ49DRAFT_1506</name>
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        <name type="scientific">Humicola insolens</name>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAL1839436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="34"/>
            <end position="60"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="167" mass="17753" checksum="AE65D1195430518D" modified="2025-10-08" version="1">MPQTGRGHPARLHLRATDFARAIRDFLYQSKTSQTLAHHQLRQTESSPSRSAKDRSRRRIVYGDSSRIHLELTPAFVSRESAPAVASPAPLPCITFLFVIDRAQTFHQSGRDVFISSAAAASGLGPSPSTADSSASGSAVVAPSSARDPSAASPGIPPSHRSLGRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCN5</accession>
    <name>A0ABR3VCN5_HUMIN</name>
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        <recommendedName>
            <fullName evidence="3">Imidazoleglycerol-phosphate dehydratase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">VTJ49DRAFT_1391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
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                <person name="Hansel C."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000150">
        <property type="protein sequence ID" value="KAL1839570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Rcf3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39153:SF1">
        <property type="entry name" value="AGR244WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12258" checksum="EFBCF612B8E322E7" modified="2025-10-08" version="1">MPSINDTKHQEATDASWEASRGAVYGAVKWGIASAILGGIGYAVSPIYRGLTIQFKVYLQMSGMVLGSMMEADSRLRAFEDRIRVQKRLAREQAYWQRIKKELGDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCR2</accession>
    <name>A0ABR3VCR2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045003205" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="25"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="698" mass="77515" checksum="61178138AF795DD6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCZ7</accession>
    <name>A0ABR3VCZ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000145">
        <property type="protein sequence ID" value="KAL1839690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22071" checksum="5A1CB06DADE12553" modified="2025-10-08" version="1">MRPIRPNFPPQSDTNHRKEEASRTAPNQPPPTDFGQLDVLASAPVPSTAVEVCRADGFDLNSGVTIRGGGALLVGGEAFRWKPWEVESSSSEGEGKGEKRIAKEGRRKRTRLVNEKGQWQAGEEAFGLLGLVWPRPDLLILGTGPKIRPLSPATRQIISNLGMRVEVLDTRNAASQYNLLATERGVDDVAAALVPLGWKDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD02</accession>
    <name>A0ABR3VD02_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000149">
        <property type="protein sequence ID" value="KAL1839584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="801" mass="87373" checksum="3EC4C94EB1002759" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD85</accession>
    <name>A0ABR3VD85_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000143">
        <property type="protein sequence ID" value="KAL1839721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="758"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="838" mass="89822" checksum="B99D2A471EF03F28" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDT0</accession>
    <name>A0ABR3VDT0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="7"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="274" mass="30669" checksum="C84BD66D5FBEE341" modified="2025-10-08" version="1">MMALTVDKSDAYVLRDMYEIPESVAVEKFRAAWDVVAQYNPILRTRLVFIPGLGTCQVVVDEPIPWQHGDNLDEYLNNDRSKPMNYGTPLARFAIVNEGTRKVFVWTVHHALYDGYSMDITLAAVDHAFRTEFGVFPTRPFAEFIGYLDKIDKDALKQFWIQQLTDLETSPFPVAPTGHRCQADNTVQYAVPFSLDRRAGVTTATLLKGAWGILVSRLSESQDVVFGVTQSGRDVELAGIERINGPTITTVSSPIGLLPLKGKWCADPFRNRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDU9</accession>
    <name>A0ABR3VDU9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="490" mass="54092" checksum="AF72C79792F4E096" modified="2025-10-08" version="1">MHRPTLPIESLPFWARLNDVSFRHVKVSKIDGRGYGVVCEDDVETAEENETGQSTLVTVPHDLVLNAAAVDEYAKEDKNFRQLLDAMIGHRSTRTDILLFLLVQTALASRSGHGSVGVSNPWTEYLQFLPETVPVPTLWTEDERLLLRGTSLEAAVNAKLSALDAEFGLIQQKSSDIPAWNELLWEGTSAVSFPDWIRLDALYRSRSLELPRSGEALVPCLDMANHSASPTAYYDENLKDEVVLVPRPGVRLSKGDEVTISYGETKSAAEMLFSYGFVDPEATTGESLVLPLNPFPDDPLAKAKLVAFGQPPRIHVARDGDVNAGGGPVRWASAFAYFMCVNEEDGLEFRVLQERDGGRQLRVFWQGADVTDRTSDFEALTGEHSLAAIFRLRVVVTVQETLRAQLERLEATAPQDPTTPSAAQREECFRSAMALRSIDTKLLEHAVEALEDERLTLLADKNVVAYLGLTEATESDLAVDEAANETDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEL2</accession>
    <name>A0ABR3VEL2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cohesin loading factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000150">
        <property type="protein sequence ID" value="KAL1839566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="99511" checksum="B9E958EF770BEDFF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VES1</accession>
    <name>A0ABR3VES1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000118">
        <property type="protein sequence ID" value="KAL1840312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="80"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
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        <location>
            <begin position="507"/>
            <end position="551"/>
        </location>
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            <begin position="157"/>
            <end position="175"/>
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            <begin position="269"/>
            <end position="280"/>
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        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
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            <begin position="349"/>
            <end position="361"/>
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            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="62511" checksum="FF1023B4CAC21248" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VES9</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_1009</name>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <end position="491"/>
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            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="562" mass="62398" checksum="2023CE6B6945BA69" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEV2</accession>
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        <name type="common">Soft-rot fungus</name>
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            <taxon>Sordariomycetes</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAL1840384.1"/>
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    </dbReference>
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            <end position="16"/>
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            <begin position="107"/>
            <end position="202"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="208" mass="22679" checksum="0287F30459504DCC" modified="2025-10-08" version="1">MKAFIVYSLLAAVAWAIPMPAPAPAPTPPGIPSKSTAQSQLAALTVKAAYDDGNYKRDKFPHWNTVSGTCNTREYVLKRDGVNVVTNSACAATSGTWYSPFDGATWTAASDVDIDHMVPLKNAWISGANTWTSSKRTQFANDISLPQLWAVTDDVNQAKGDKSPDLWKPPLTSFWCTYAKSWVTVKYNYQLSVTTAEKSALTSMLNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Soft-rot fungus</name>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAZGSY010000123">
        <property type="protein sequence ID" value="KAL1840182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="133"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="43"/>
            <end position="60"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="158" mass="17239" checksum="63C270EECDCCE94A" modified="2025-10-08" version="1">MPLRQPRNWYSSMAKSVIQASMSLLIRFIQQCCRSSAHYDESASDHEHDHEADSYDESRHLSRGSSYSSYYYYCSLLRHAARKPDGTTLDYGSVTGGDYPCYGLMRSGYGGDCDNDSVAEECGCGCDACTGAASVPAPGTDGQEEYDADDEGSEEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFM1</accession>
    <name>A0ABR3VFM1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="183" mass="21609" checksum="AAAEDB14FA2DFD9F" modified="2025-10-08" version="1">MDPYYGMYGESAQQPAQPATYRPTKPEDWEPYRDIIAHLYNTLNMKLKDVMVEMEMSYGFKATEKQYKTQLKKWNLDTKYIKGSEYMYMIKTMRERQAENPPKETRFILRGRVVDPKDIARFEKRAQKKGLLREGQPIVCDEPVEDLVYGTPPPEEVAYHQAAYVEAYTSYQYDPATDYGYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFP6</accession>
    <name>A0ABR3VFP6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3046</name>
        <name evidence="3" type="ORF">VTJ49DRAFT_682</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="66"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="394" mass="42811" checksum="F4342F4BBD6ECDAC" modified="2025-10-08" version="1">MMASSNEALETLSSVVGNAVALVGQLDTVVASIAAEKRAPAESAVEARSGAQQLGTLDALAVAHDSAALIKAHATKISLLIINEPFTPSAVTKVVRELVSAAVPSLAAAVEACSPERYTRSIQLDLAYRAGRALRELKELLLRIPKDGKVLSGADKNSSAGSAGGRGSIATTGVLWSACDDVMVFGRRGFAGNLAHKIEQLRDTLKDIMEELKEWGEESEENESDDDDDDDDGDNDGVAQVTSQLASSSISPAQDAQAILDDFMSSQRYIPRDDPDRIRDRLDSCLKRLRLTTLLYQATAKRRLKPLPHLPPTSPSDVPARLDEVIPIFKRLPEKFGSLAMAFYDLDPAEINRLMDECFFDAFAAAELLAKPWEGQKDEFTDWVLRFQVEIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFR1</accession>
    <name>A0ABR3VFR1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Otillar R."/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="85"/>
            <end position="531"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="849"/>
        </location>
    </feature>
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        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
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        <location>
            <begin position="556"/>
            <end position="639"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
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        <location>
            <begin position="833"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="938" mass="104827" checksum="F42549B84E244DE6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGT6</accession>
    <name>A0ABR3VGT6_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7649</name>
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    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="125"/>
            <end position="301"/>
        </location>
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            <end position="381"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
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            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
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            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="323"/>
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        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="381" mass="39468" checksum="FE2DAB61D07D6B3B" modified="2025-10-08" version="1">MPDLNSVPPSPRIPQAPIRRPSSQQMRQSGPASPSLNILPSNQSTVNGTTSSALPSPSIPVTSSFGSLPMPSTAGDSTGVGPGPGPLRHPRPLTAADLHLQLEREQEAVVNRLTRELQMLRAAHNASVVSNASSTSASAVGTEPGPGTDSANHPHPVPHHHRTSSNASARSFTLSSASLTGISSPAPIRPTPIPPHQQNPTSAAISISRQNSTASRRSRTGSPSPAPSGARVSLSGSYREGAHPALARSYSGSTSGVVPTPATGGSSDPMSPAILPGTSRFEETARRRAELEEVKKENEALRRRIKELEQMVREAAEAKRRGEGASAGANARAGVAESRSEAVKQDANGEGEGEGNRAQQVSVGEHVESAGAGRGRGRVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3VGW8_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">DNA-(apurinic or apyrimidinic site) endonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000117">
        <property type="protein sequence ID" value="KAL1840346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="13">
        <location>
            <begin position="577"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="388"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="633" mass="70199" checksum="5C34791F23738EEC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGZ3</accession>
    <name>A0ABR3VGZ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial resolvase Ydc2 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000094">
        <property type="protein sequence ID" value="KAL1840928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="2">
        <location>
            <begin position="53"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="400" mass="43097" checksum="23A1076F7D30A6AC" modified="2025-10-08" version="1">MSPRDPLLRETGATLQSLCASCGLRKTGTKAVLAQRLRLAAQTFRPLPQDARVLSLDLGLRNFALSLVSPVETIPGKGGRRRRTGVGGEEGVLRTPVRLLAWERIDLMAPLSSLSSLSSSSSSSSASSLEEADPEAVPEAQSEASSSSSSSSSSSQDDFSPASLATSTLRLVTSRLLPLRPTHILIERQRFRTAGAAAVLEWTVRVNSLEAMLHAVLAALNQQNRAGKVLGGDGDGDGGRVPTWWWRGRAESVTPKLVAGFVLPGVGSKSAVEGDEGEEGEESGKKKKKTGRGANSAYQLLKQGKIKLLTELLEGGMVQPEEGRVSDMVTRFLEEAERKATKTRRKKVPGDADMVDIGKMDDLSDSLLQGMTWVQWQNNLETLIRERPELLEPVDDSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHQ9</accession>
    <name>A0ABR3VHQ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045595405" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="210" mass="23817" checksum="97668C01DAA96133" modified="2025-10-08" version="1">MQLPLLQCGLWALLASQAAATALTYKLNPNEEACFYTLSEQKDEKIAFYFAVQAGGSFDINYKVTGPNGRFIMEGEKERQGDFVFTAKEVGEYKFCFNNEMSTYTEKFVDFEIAVENEARVTLPAKKGAAPEQTSTLEESIFKISGQLSTITRNQKYFRTRENRNFSTVRSTESRIVNFSLIQIALVICMGALQVFIVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHS6</accession>
    <name>A0ABR3VHS6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="650"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="723" mass="79200" checksum="030A5E4B7967FF5D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHT9</accession>
    <name>A0ABR3VHT9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="356" mass="40284" checksum="08752542C099BC39" modified="2025-10-08" version="1">MLSFNQPALYQASKCYVTWGAMAHLDPKQVPSKSKPWASLATQDFVHRVDLVMPQEVFELVQEKLLQDRPAPTFRRVVMSLHDILTGDFFTEYIKNGNILMLSEGRRGIDNVFYLRSGTLTMLLDKETYERAGLVGKPHGVKGKRGLKPRWIVEIDLTTPSMVKGKKGFDRLLYASKNTLAAPVTWLFCNISSSIPYPDPLTQSSPTTYTCRPNVSQKMDVLIPKLSVDADPESPDDQHHLEDYATELYEWLSLVRLQSPRLRVGDQIDPYLSRYQVPEGAETGKVCTISWQGFLAPSWTRQTLIDIILAVPHTAWFAFSATTFTKGLAGDNVECTILRLPESNGQYLMWEVKAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHV1</accession>
    <name>A0ABR3VHV1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable dipeptidyl-aminopeptidase B</fullName>
            <ecNumber evidence="4">3.4.14.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dipeptidyl peptidase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_7025</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF162">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045360264" description="Probable dipeptidyl-aminopeptidase B" evidence="15">
        <location>
            <begin position="18"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="17">
        <location>
            <begin position="102"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="16">
        <location>
            <begin position="569"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1841470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="785" mass="88535" checksum="88E9887743EB15D4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIF1</accession>
    <name>A0ABR3VIF1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="2">
        <location>
            <begin position="388"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1375" mass="148133" checksum="677D6844AB4A8157" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIJ1</accession>
    <name>A0ABR3VIJ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="172"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="268" mass="30183" checksum="2C67E809CEA51917" modified="2025-10-08" version="1">MFAPRTGRQALRRALAASPSQTVTLPSFLVPAFQTQPTTPISTTPTPTQTPSARRNFSATTHCASKLGRTPLTVPPGVDLEISDLFYQKDMTSYLKQYKRRVLVKGPLGQLELDVPEYVNINHDPATRRIELSVRDQNEKMQREMWGTTWSYLNNHIMGVSEGHTAVLRLVGIGYRASVESRPEKEEYPGQQFVCLKLGFSHPVEMGLPKGMKASAPQPTRVLLEGINKHEVMQFAAQIRRWRVPEPYKGKGIFVNDETIKLKAKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIW1</accession>
    <name>A0ABR3VIW1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear membrane fusion protein Kar5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_6754</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046028584" description="Nuclear membrane fusion protein Kar5" evidence="13">
        <location>
            <begin position="18"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1841648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53267" checksum="79F6ACB2ED5B2DA2" modified="2025-10-08" version="1">MQAYLLFLSLWASHVDGLSWRSEKRLAEVNSEKPSEILQQNQNSRLPNIYAVALSELQELESEPLCHRVAARLLVNNCQLVDGKNEATILTDSGRQVRDFVDSYAASLAICDLERGSFQIPRECAKFREPSLSQIAMRNEPQLHVSPGEIGLCLSALAASDAAWSTWVSYRHKALRFCEAARADNEKAQNILLYQRLTRIIAKLTDGVEDELQKRMEDLDNRARQSIEKMEQLSPHMGRLSEGLARVERFLSQDMDSALKRTSQSYQDGLEHAENLQQLLRLLVGNVLESNSQLAFAHEQSVQQATQRVSEDMDALVAVVSSAIASSSSLQQQIQFSNQQASMLAQRQDHLEHGMDRLVTATETLTTKFQDHYHILHQANNLTNDILDALEETAAVASSMQESFLTRVTTRSWWPFIVFPTASLVIGSYGLPPSMVRNIGLLAFGEVVGFVVSSYEQITGVIFGSVAEVAGVNSTAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJY9</accession>
    <name>A0ABR3VJY9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1912</name>
        <name evidence="3" type="ORF">VTJ49DRAFT_6131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000178">
        <property type="protein sequence ID" value="KAL1839048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12327" checksum="27A006D212C282F4" modified="2025-10-08" version="1">MASKDAPPAYPQPTYGQQPPPPGGANGSYYYEQQPQMGYGQPQGPPPPGGYYQQGYPPGQQPPPAGYYYPAQQPVQQEKSGPGCFEAFLAASRSRELMISRRGFSTMEGHVTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK41</accession>
    <name>A0ABR3VK41_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000051">
        <property type="protein sequence ID" value="KAL1842179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="628" mass="68544" checksum="C41D80A23E48EA4E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKL1</accession>
    <name>A0ABR3VKL1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="175" mass="18673" checksum="BFA98BD1304414B6" modified="2025-10-08" version="1">MGLAHGCPHRDAGVVTAVAGLSFLESTSQLSSGRTFLFYFSILPVIHVVLSSYDTESASRPASGEILALAGPLPFHPRFCGRVESTKLRTTPHLRWLARRSRATPDAAIQGAPVDSALRSEPPGISAAPDPRRTLSLLKLPRSRMFGDQAIVSAVPVHQAPLSPQISPLDDSDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKP3</accession>
    <name>A0ABR3VKP3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5190</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045241583" description="tripeptidyl-peptidase II" evidence="12">
        <location>
            <begin position="16"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="13">
        <location>
            <begin position="208"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="592" mass="64922" checksum="95549FA77EB4640A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKS9</accession>
    <name>A0ABR3VKS9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46510" checksum="8328E9AD2087E9E2" modified="2025-10-08" version="1">MAEAKAPWPTGLSYHSVEHLSDGNSWGFSIHYHYNNQGFAAVISTSPPAGFDSETAIERKWLDRLWELSTHDSVPEDEGDEQILQRLQKQSEGEQEVAREIADLILPTLQRLAGPPLAAPPPPPKPTPEELEQQRVTGPPHGTTTVSDLLFPPCTLLEVVTKDGTLEVLSDRTEELRAKAHAIPWAVLREEMGVEPGFVPSFSAKDVVFRRPGPGVGVYYASVPGSDEELIGKLTDSFDKRFLEKELEKYVKLWKASLDPEARVPKLKGLITHGDFGILGILLTKISAKHASLEPLITGSPELPYGQQGRLISANPDSLPAHRPTPPPPAPRPSLERRQRWAAQIEHTVRELHKHGVTWGGVRPENVLIDVDDTAWVVDLRGSGTPGWMPEDEQLLGTVEGDLEVLGRVKEVLLREDGDGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKV8</accession>
    <name>A0ABR3VKV8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF8">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37393" checksum="0DEC946A5F08FEA5" modified="2025-10-08" version="1">MASSKPKPTPQPHPLKRLLDTLTDLNPLHCLHLSLHSPIWHFVERVYALPSPPPPRVRTQPMQVLCVGLPRTGTESLQQALLKLGYNHTYHGWDVVYDPDGCYAPKWVELARKKWYNNGQGGGGRRISRQEFDTVIGHSVAVTDAAASVFAADLIAAYPEAKVVLNMRRDIEGWEKSLRNTLVHANESWAWWLASWLDRECFWSWHVYERFLWPLLFRAGDGDMKRAIEGNARWIRQEHANMIRGLVPKEKLLEWYIEDGWEPLCKFLGKPVPDEPFPHANALQGGWKEREEQANKRWIEGAFSRLILICFGLAVGIAVARRWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL37</accession>
    <name>A0ABR3VL37_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="91"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="617" mass="69077" checksum="0528C8648D85A7D6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL66</accession>
    <name>A0ABR3VL66_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="146"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="409"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118976" checksum="C3D513BB41A1CA9E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLG1</accession>
    <name>A0ABR3VLG1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaminase GtaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="1">
        <location>
            <begin position="341"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="75654" checksum="916E75811BDAF261" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLK0</accession>
    <name>A0ABR3VLK0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000064">
        <property type="protein sequence ID" value="KAL1841786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056896">
        <property type="entry name" value="SIDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24895">
        <property type="entry name" value="SIDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="780"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1584"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2111"/>
            <end position="2167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2204" mass="237908" checksum="0AD0311C47DE78D9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLK3</accession>
    <name>A0ABR3VLK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_4679</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="6"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="382"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="893"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="690"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="759"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="932" mass="102770" checksum="8C9A8EAE59EF68C3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM09</accession>
    <name>A0ABR3VM09_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="9">
        <location>
            <begin position="164"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="10">
        <location>
            <begin position="495"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="853" mass="93056" checksum="2F2F11C3CAF640B0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM48</accession>
    <name>A0ABR3VM48_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="356" mass="37089" checksum="8895B1F50845D092" modified="2025-10-08" version="1">MAATDNGNGKKVAADFEKMIHEARDRKKNEALAAKIFGRSTSSKPSPAGNLSSRAGVKKNRADSAARPRHSTGSIETEWTHDLHDTVNPRRPAANGKASGSGAASLASRITRPGERPPTAPAAQRQQRRAAQVARALIKSELQAHPHSAPSSPAGNGAVAIPTGPKAMMAKKATAKPAAAAVPDKGFTIRGLAGPFVVLAQNFAPGTTAADIESAMTPVGGLISSCRIVKTHPIVIAEIVFENKEGADRVIQTFNDRVADGRVLKVFHKPGNTPSSASVPPANAPTGPRAASAVNDMVVDGSYGFEDPMETDNNNNNSGGFSKPPPTGPAADAKSGRLYSDSMVSRRGRGWKQHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMB5</accession>
    <name>A0ABR3VMB5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000040">
        <property type="protein sequence ID" value="KAL1842545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="387" mass="42866" checksum="E8DB7AF665A37745" modified="2025-10-08" version="1">MKDTNLLAQNDNELPHLWQKPTSKELLSCLEKLRVQLRVWNLRYDSPARTTKERQQQAASTSTYDRREVISFLSSVISSPLAWLDSDEEREMIWDQASKRMAERCGRTAMGEITRHWPFEDAAGEFTLAIREPPLTGDSLGLKTWGSSYALARLLPTFSSPDGPLAHLFATNSSDSTRYPALGEKREILELGSGTGLLGLAAACLWSANVALTDLPDILPNLRHNAELNADILASRGGSARVVPLTWGGTAEEETDPAFLERMNSYQLVLAADPLYDDNHPSLLARTIDEHLSFSPSARVLVMVPQRDATTKRLLGELRELLAAGLRALPPLRCLAEDIVHGQDDWVEEDGGPGDDGNDEEEDEHHRVGFWWGVFGREMGAAEVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMG9</accession>
    <name>A0ABR3VMG9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cyn1</name>
        <name evidence="5" type="ORF">VTJ49DRAFT_4460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13560">
        <property type="entry name" value="HTH_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="4">
        <location>
            <begin position="108"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="181" mass="20169" checksum="5960A2BE7B5B91AE" modified="2025-10-08" version="1">MTEPLQRARRNSIVHIAEQRQNLASLDSSIIDRLPSYSAALFEAKTAKRLTFEDIARALGRSEVAVAALFYGQARASPEDVARLTELLGLSPETNVAAQMMGFPDRGRAGPMPPVEPLIYRLYEIVQNYGYAFKAVINEKFGDGIMSAICFHSKVEKEVDETGSSWVVITLKGKWLPFTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMK2</accession>
    <name>A0ABR3VMK2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="86"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2179"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1161"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2264" mass="245144" checksum="8518EF500246ABD1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMS7</accession>
    <name>A0ABR3VMS7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF113">
        <property type="entry name" value="MEMBRANE PROTEIN, MPV17_PMP22 FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="315" mass="35434" checksum="3503B3A6FF62C020" modified="2025-10-08" version="1">MAFLTRIVSCTNFVVASSALAFQVGVLYPWHIQLDKEFEKLRTEHLRVLKAIGERPAESALRRHIDLLRKQRQRRMHSTNRGNGADPNAPVKRPLSTSPRTQDQVPTPNNVPTLNFWQRLGPFTRVAQAYARAQRKRPYVTQVCTSLFIYLCSDISAQSMGGRDYDPTRTARSLLIGSLSSIPSYHWFVWLSESFNYPSRLLSIATKVVVNQICFTPVFNTYFFGMQALLSGATLAETWERIVHTVPVSCVNSCKLWPAVTAFSFAFLPLEYRPVFGGVIAVGWQTYLSYLNRLAEQRVAAKAEGLQAAGIEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMY1</accession>
    <name>A0ABR3VMY1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5729</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="100"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="781"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="500"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="830" mass="93195" checksum="6E4F5C2CC0F49409" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNB5</accession>
    <name>A0ABR3VNB5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="222"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="581" mass="63668" checksum="4F6F2EFE256C1E3B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNF7</accession>
    <name>A0ABR3VNF7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="844" mass="86952" checksum="C671EE7F65C222B5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNK8</accession>
    <name>A0ABR3VNK8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="361" mass="38401" checksum="65C8C866001738EF" modified="2025-10-08" version="1">MAARTVRTLKIGLIPGDGIGKEVIPAGRRILEALPASLGLKFDFIDLKAGWETFQEQGVALPEETVSVLKSDCDGALFGAVSSPTTAVKGYSSPIVALRKRLDLYANVRPVKTVVSAPKPIDMVIVRENTEDLYVKEETTRDTPQGKVAEAIKRISQRASSRIATIAGEIALRRQNIRAAGAPSIHKGPLVTITHKSNVLSQTDGLFRVTAREALTAPRFADAGVKIEEQIVDSMVYKLFRQPEAYDVIVAPNLYGDILSDGAAALVGSLGLVPSANVGEGFAIGEPCHGSAPDIQGKGIANPIATLRSAALMLEFLNEEQAAAKIYAAVDANLEEGKLLSPDLGGTATTEEVVQDILRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNP4</accession>
    <name>A0ABR3VNP4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="315" mass="32592" checksum="A51128552AFFED17" modified="2025-10-08" version="1">MTVPKSEYLSNAWADGIFANRVLFITGGAGTIGSAQTRALVHLGADACIVGRSVEKTEKAAVEIAKVRPGARVLGIGGVDVRNFDALKAAADRCVKELGSIDYVVAGAAGNFIAPLSALSTNAFKTVMDIDAIGTFNTLKATVPHLLTSSSRTKSSPSPGGRFVAVSATFHYTGMPLQSHVSAAKAAVDSIIASAALEYGPLGLTANCVAPGAIEGTEGMERLASSLVKREERGKGIPSGRWGTVRDIADATVFLMSDAGSYVNGTTLVVDGAGWRRQGGLEVGLDPGMSYPDFLVKGEISRHLKGGKKKGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP12</accession>
    <name>A0ABR3VP12_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="288"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="584" mass="65865" checksum="7354572EC11E9788" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP59</accession>
    <name>A0ABR3VP59_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="614" mass="67403" checksum="30A4641D4CBA026C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPG8</accession>
    <name>A0ABR3VPG8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="473"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="641"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="824" mass="93301" checksum="F3A038C470A56587" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPM4</accession>
    <name>A0ABR3VPM4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="68653" checksum="FE8F4CA2D19869E1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ23</accession>
    <name>A0ABR3VQ23_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="106"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="348" mass="38734" checksum="FF88CE99367C4D56" modified="2025-10-08" version="1">MAAEPAPAPLKTDPKYDDYDYPTTAPVPANGHPGYLTPMQEAQVFQLRMLLEAEGYKERLDTLTLLRFLRARKFDVNLSKQMFIDCEKWRQEIKLDEILPTWEYPEKEQVFKYYPQYYHKTDKDGRPVYIEQLGNIDLTAMYKITTPERMLTNLAIEYERVADPRLPACSRKAGTLLETCCTIMDMSGVGISKASQVYSYVKSVSALSQNYYPERLGRLYIINAPWGFSAVWNMIKGWLDPVTVQKIHILGSGYQKELLAQVPAENLPKQFGGTCECPGGCQLSDAGPWREPEWARPAKWEKKKEDAVIVGAPSEIKEDGEGAEGAAPAPAGAEADGGAAAAPAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQA0</accession>
    <name>A0ABR3VQA0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1844095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="163" mass="18803" checksum="93640012F396182A" modified="2025-10-08" version="1">MANLPWELKAPKMIGVKLTGQMSGWTAPKDIILKVAGILTVKGGTGAIVEYFGKSERWSCVSSFSRFPFFNFTVVFVVLPLFHDSFPLSFFPSFSASFPLSFLSFFPFRIFVYFLNYPFSYYPFFPSQPLLFFFVLHFSVLVSRYDCRSRKIVVLSILSRLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQD6</accession>
    <name>A0ABR3VQD6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOSIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="295"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="491" mass="52675" checksum="126FF0506891E13F" modified="2025-10-08" version="1">MAHSKRNTSRPVFTSHERAVARAAWGSSSARLGRDSFLPFASCWLCLEPAVDPVACLHGDIFCRECALSNILAQKREIKRAEKAREHEEREAREEQARREAEAQERAIRDFELTQQGLSIQKGTAASRTTTSATAEAVTVRGNGGSNGAKTRDTAVSPGSPPNHNSHGRSSNPRAGDKRKFSLDPDEVARIAEEERARARRALDDEKAATKPALPSFWSPAATNNSNGQQHEGKKRTKTQPVCPAAPEDKPHTYSLRTLVTIHFSEETPTTTGGAGSPESASGGNTQTKPPQRICPACNKALTNSSRATLAKPCGHVLCKNCVDQFMRPKKSAEEPVRCYVCEADLTEETASPTANSESGNNSKKKEGHHNKHKDKSDKERIRPGLVELRREGTGFSAGGMNEPWLLSGPSVGECSRLGGAGHCPMPSAHAAQGCPADDITPGPAPSGPNHEVVGGTEPSRFGARSWQTPQGKANPLIMNLPAASGNKCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR53</accession>
    <name>A0ABR3VR53_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1844000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF15">
        <property type="entry name" value="ALPHA-FACTOR-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="820"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="858"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="932"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1040"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1084"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="69"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="395"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="821"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1331" mass="144859" checksum="BF0BE4643731A71F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRF2</accession>
    <name>A0ABR3VRF2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1844294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="363" mass="39626" checksum="3B87922352E5BA23" modified="2025-10-08" version="1">MTTTRVSVLRHLQTGSGALRSGPLASPPTPLHQQRRWARVQDVRFFVATACDRQQDLKPGVLEKYRDKLARKAQEEGHADIDSLRAAYAEKIDGLRKEFDAVVPPLAGGKQSTAPAPSQHSSLTQPPPPPQPIPEAASKASEAPASSTGVKPLSSILDIPKASALPVKELTAIWRLRHASNPRSLCAVIPAETFATMEAVARQQPQFVLPVPVTARPAPSSQEGQQQQQGRGGQDGGAEIHFLQWTWDAPTRTATVLFTQLAEYKARGEFAAPHTTVTHYRDLAESHGVVLMQGHVMDDRGVAVEDARWLVMCLQRFYGGWDGAGGNAGKERADSRRRLLEWFAKGDGRFTVEGLMEEAERMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRI3</accession>
    <name>A0ABR3VRI3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_9</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="162"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1844330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="277" mass="30899" checksum="86457B26BC8DA9B6" modified="2025-10-08" version="1">MSSADLYQQPDQPDALAEGRRIYVGNLLYSLTPGDIEAVLRDSGFPHYERIHISIDPVSGRNPGYCFVEFPSSRDAEDALNRLGGVLVQDRPLKVGPCNPKSTPRSARRPWADRGQLAFNRWGDWTPEKRTPAEPEEQGPYGALQHHAVETSTLQPDGRHIRRLYIGGLGKMYDQTHNQAEMKEILQGFNYVAIGKRITPRQGQHHYCFVDFPTAEEAERARRALNGAEWNGWKLVVQLAKGLATPLNGQDSRPDGVDSTSRRDIGSIGLIYVALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRV4</accession>
    <name>A0ABR3VRV4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Na+/H+ antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_77</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="458"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="457"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="749"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="810"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="810"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1844398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="105685" checksum="F9B32DE27514D545" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0R6</accession>
    <name>A0ABR3V0R6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000693">
        <property type="protein sequence ID" value="KAL1835388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1835388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="232" mass="23037" checksum="A88C4889087E878B" modified="2025-10-08" version="1">MQLPSVINTALTASRGIAGIGLVPPASVKDNTGNIPGWDAMKQINIDIPSNIREAASNAGKYAREKVADGANWAKDNTGNIPSLDAMKRINIDIPSNIRDAASNAGKYAREKVADGVDWAKENPGSAALGVAAVGGLAVVAAPAIVSSPMLAAAGFGPSGPVAGSLAAVAQSSIGNVAAGSMYATLQSAAMGGYGVAQVAGVVQSAGACIAAVAGAGAVMAQNKEEENKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0V8</accession>
    <name>A0ABR3V0V8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cellulase</fullName>
            <ecNumber evidence="3 9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 9"/>
    <dbReference type="EMBL" id="JAZGSY010000712">
        <property type="protein sequence ID" value="KAL1835357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047483643" description="Cellulase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 45 active site" evidence="11">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1835357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="223" mass="23882" checksum="42A58E73FBC982B2" modified="2025-10-08" version="1">MHLPLTTLLTLLPAVALAQSGSGRTTRYWDCCKPSCAWPGKGPAPVRTCDRNDNPLNDGGNTRSGCDAGGGAYMCSNQSPWAVSDDLAYGWAAVNIAGSNERQWCCACYELTFTSGPVAGKRMIVQASNTGGDLGNNHFDIAMPGGGVGLFNACTDQYGAPPNGWGQRYGGISSRSECDAFPEKLKAGCYWRFDWFMNADNPNVNWRQVSCPAELAERSGCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1V9</accession>
    <name>A0ABR3V1V9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000540">
        <property type="protein sequence ID" value="KAL1835770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045554984" description="WSC domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="39"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1835770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="520" mass="55045" checksum="847C0C25875DE1DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2P7</accession>
    <name>A0ABR3V2P7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000473">
        <property type="protein sequence ID" value="KAL1836053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="398"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="661"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="808" mass="89867" checksum="0FEE9BC133EF93A0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3L9</accession>
    <name>A0ABR3V3L9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000421">
        <property type="protein sequence ID" value="KAL1836374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="346" mass="39872" checksum="157F6DB8D7AAF40C" modified="2025-10-08" version="1">MSDNVGLPTPRGSGTSGYIQRNLAHMKPRDMAAPYPPRDNDRQHRPRQPDKGLLEHERKREVEVKVFELRDRLEEEGVEEDEIETRCDELRKKLLAEMERGGDRGVGPTRKTFKMHQVHELADAKIKESERLRQALKISRDYEEGSHWRRQEEKLKKSLEQQEAERKTPESTMRLLLPALTSLALLAPAMAAPAGDATKSPSLWERALSWLVPREDLCHLPSPPQLCVPNASVTVEETALRAYQFYRAFVVDGDPRTMFSLIDDVYIQHNPFYQDGPQAIWRLFCGGRRIGSEESTSWCFDASTNMSYANYGNIDRWKWVDGCVHEHWDQGERMPSPDKCYQLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3Q0</accession>
    <name>A0ABR3V3Q0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000418">
        <property type="protein sequence ID" value="KAL1836385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="324" mass="34946" checksum="AB74A4F8B47DE91F" modified="2025-10-08" version="1">MVFAARATLVSSFTQPPAVPVGPLQTGLAVSGILLPTVHVVSYLSSYPTPKLVLFIVLPITNMLSFGINNVLLAFAGAVLPLLSASPHPLLGNGIPLRIMPLGASITYGLGSSDWNGYRAALRSLLLTSTPRAAAVNMVGSLHNGTMIDNDVEGWSGFRITQVHEKAMNTSDKAVLYWKPNLVLINAGTNDAAQGYQIPSAGWRMESMMRDIWEASPRATILLSTLLVNKNPTTDKHVLEINEQYVRLATRLREVAGRPVVLVDMHGEDGPGYEDIPDGTHPTDEGYVMMARLWYRGVVEASHAGFLQAPEVVEGVPDDGDVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3R9</accession>
    <name>A0ABR3V3R9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="14" type="ORF">VTJ49DRAFT_5159</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000413">
        <property type="protein sequence ID" value="KAL1836423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="12">
        <location>
            <begin position="60"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="169"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="11">
        <location>
            <begin position="385"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1836423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="495" mass="53626" checksum="E7CE77F4D9E23896" modified="2025-10-08" version="1">MSIPGLGQIAPPQPTTTSTTRTITLRPFWEYRFEVPRRTGPTTVTPSTTNLPTGTTPSTTSATTIRLTTGKAERDGTELALNHTYAFPRGTRARILTYTGATLEVAGELPASERVAQYARPEDSPEVQVLNLHFALQEARKKAKERSRRDGGRPEQQQPPPGPRVLICGGPDTGKTTVARTLTGLATRAGGQPLVASLDPREGMLALPGTVSAAVFGTVMDVEDPAGGFGVRGTPSSGPSAVPVKLPNVYYFGRERVEEDVPFWRTLVGRLGGVVRAKMAADLVVGESGLVVDTPPASVAKGDIEMLRHAMMEFAVNIVVVVGSPDVQAALQKAWGSNKTLYGEPITFLPLDQSDGVVPRDYEFTKFTREAAIKEYFFGDAKRTLSPFTQSVGFDDLVIFKTPDDAEEGYDNRPDGLERAEISAEMSHWTLAVMNASVNDPLETIRQAPVMGFVAVADVDEDRRRLKVLSPVSGRLGNRPLVWARWPEPYINLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4U2</accession>
    <name>A0ABR3V4U2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">beta-glucosidase</fullName>
            <ecNumber evidence="16">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VTJ49DRAFT_5085</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="16"/>
    <dbReference type="EMBL" id="JAZGSY010000406">
        <property type="protein sequence ID" value="KAL1836471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="869"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="771"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL1836471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="950" mass="103387" checksum="0922DA4A381A4CEA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V586</accession>
    <name>A0ABR3V586_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000349">
        <property type="protein sequence ID" value="KAL1836925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="473"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="628" mass="66838" checksum="506FECD1F6DFAEFC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V628</accession>
    <name>A0ABR3V628_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000318">
        <property type="protein sequence ID" value="KAL1837209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="232" mass="26003" checksum="85DA8FC53127CB41" modified="2025-10-08" version="1">MIFLQQPTANAADGGAPEIRRSSGWTVPHAWDSGLAVLFETRTSCMQTVFGELGWCFNCTQVVGRFLAVLLELGALGFIAYLYDYWKGEPTTRVDLLVPSFAPVVGGVVIDTYELVSLLFLSRRRAINYPIMFFDVSMIAVGIFSFLVLGLVEKGSGRLRAAWAKDMTNAMIFMIIFTLLHAGFLVLAVAGIVYSYRVDRKKWAKSRLEKHRRTIVEFYQRRKQAASQPTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V641</accession>
    <name>A0ABR3V641_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microtubule associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000331">
        <property type="protein sequence ID" value="KAL1837085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
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        <location>
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            <end position="509"/>
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            <begin position="576"/>
            <end position="591"/>
        </location>
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            <end position="666"/>
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            <end position="692"/>
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        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAL1837085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="87350" checksum="41611BACB50DB7C5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V656</accession>
    <name>A0ABR3V656_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1837248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <end position="99"/>
        </location>
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        <location>
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            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32841" checksum="3C03302057F47907" modified="2025-10-08" version="1">MGPNRPLRGSCHCGRNLYIVQFPQNPDPDLNLAARVVFNTHSSQRTILGTPLPAYLRVPLTWHTSQTVPRHADETRAQIRRVYQLHDDMDYSDEDDDDNASPSSGGIHGRGRNKKSNNTYEIRHFCGFCGTPLSYWREQPPGEGDFIQLALGSLLPSDLRDLEEFGVLLPSSPSAPSSVPGSPRPGGEDEKEGGGAASQAGSVGLSTGDDTGDMVGIVGGLPWFDALVEGSRLGRMRWSGGTGTTAMGGEGRGTVRVAWEVMEWTEGEDAAAAPAVVVAGGESPRKRKLEEEVTGGGRAAEMEGVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V687</accession>
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            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="15" type="ORF">VTJ49DRAFT_4068</name>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000311">
        <property type="protein sequence ID" value="KAL1837282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="ARID_dom_sf"/>
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        <property type="entry name" value="Znf_C5HC2"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
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        <property type="entry name" value="ZF_PHD_2"/>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="13">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="457"/>
            <end position="502"/>
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    </feature>
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        <location>
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            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1334"/>
            <end position="1383"/>
        </location>
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        <location>
            <begin position="1"/>
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        <location>
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1685"/>
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        </location>
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        <location>
            <begin position="1733"/>
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        <location>
            <begin position="12"/>
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        </location>
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        <location>
            <begin position="61"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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        </location>
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        <location>
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        <location>
            <begin position="1564"/>
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        </location>
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        <location>
            <begin position="1575"/>
            <end position="1592"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1688"/>
            <end position="1705"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1770"/>
            <end position="1791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1837282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1799" mass="200402" checksum="5F58694C61E0EBF0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V698</accession>
    <name>A0ABR3V698_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000347">
        <property type="protein sequence ID" value="KAL1836941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00871">
        <property type="entry name" value="PI4Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="6">
        <location>
            <begin position="1380"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="1657"/>
            <end position="1925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1941" mass="215453" checksum="33B7A5C87AB89A61" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Q7</accession>
    <name>A0ABR3V6Q7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000308">
        <property type="protein sequence ID" value="KAL1837310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF64">
        <property type="entry name" value="ACYL-COA THIOESTERASE (AFU_ORTHOLOGUE AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="58"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="270"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42421" checksum="3F53FE4E4C395334" modified="2025-10-08" version="1">MSEQISPAVEDGPYPPVPALPLQEAMSMVQLPPAGAARRYMSRRAAYLPGSDFTAEAEMPAFHRAAFGGHVYAQSALAATRAWREVEDEKGVKKQERLDLHTINGFFTRPGIPSRPFLYTATPLASSRTFSTVSVIAHQPSQPSGSPSGDNYPLSDASLPLSPPSFVAICSFKRPEPDSHGASAQETPVQERFAEILSSRPPEDWPPAPPVDITGVVEMVGADQEGQFPIALMRKVDMTAYNADRPVWERVELILYKLRRPVTLQERGKEWDANAHIAAHAYVADRNGLLVVGNHVGFGHSLGRAATLSYTFVVHVNAEEAVMREEEGWWVQEMRFPRVGRGRGIVESKIWSPRGVHVATEYQDGLIQGLPGGGWPKREREEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V703</accession>
    <name>A0ABR3V703_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor rse1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000283">
        <property type="protein sequence ID" value="KAL1837554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="464"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="855"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1211" mass="134127" checksum="BE3D0671A06B3438" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7L6</accession>
    <name>A0ABR3V7L6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000264">
        <property type="protein sequence ID" value="KAL1837777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="209" mass="23334" checksum="05EA7388B5D80B8D" modified="2025-10-08" version="1">MADTAADGTRFLINNLGEIRFILLGISSRPLPANLVGTYTRVNIDLPLALSEATAFAFDMGDMLNIDTDHDGVRVGPRARRAIYGAWHRAELLRASLIIMGENPDSHIHFTTSEIAEKSSPHDNIQRPSVDPKEPIKISPHVPPRRGPSSTHLGPAKIDTTFEYLRYVSSCKSSAKMLHLLTTALLWRRGLDRAETHDECDESWDIRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7U4</accession>
    <name>A0ABR3V7U4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000270">
        <property type="protein sequence ID" value="KAL1837700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="35908" checksum="12F7F189917F2D49" modified="2025-10-08" version="1">MDSPSQLSPPASPSDPIDQPPMVLPRGVYVPMPAFFTADDEIDIPATQRHTARLLAAGVTGLVIHGSNGEAVHLSSRERRAAIEAVVDTVRHDADLAHGPVPIIAGCSAQSVRETIALCREAREAGATHALVLPPGYYRGLMNHEDIARYYEAIASSPSALPIIIYNFPAAANGVDLNSDLLLRLAAHPRIVGVKLTCGNTGKLARLAASAPPGFFVGGGSADFILQGHIVGGHGTISGLANLAPRACARIPELFDAGRIAEARSLQHEVAKADWVAIKTGFIGVKAAMPMFYGPSEASCAVPRLPFTRLEEGSEAFDGIRRGMAGLLEIERRLAAEAAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V819</accession>
    <name>A0ABR3V819_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000257">
        <property type="protein sequence ID" value="KAL1837862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="6">
        <location>
            <begin position="172"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="675" mass="76043" checksum="01DEACD2AFF308AA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8G8</accession>
    <name>A0ABR3V8G8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000242">
        <property type="protein sequence ID" value="KAL1838040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="3216"/>
            <end position="3352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="848"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1093"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1496"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1930"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2039"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2551"/>
            <end position="2581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2603"/>
            <end position="2624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2822"/>
            <end position="2844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2857"/>
            <end position="3117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3143"/>
            <end position="3170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2046"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2061"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2604"/>
            <end position="2613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2615"/>
            <end position="2624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2822"/>
            <end position="2834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2875"/>
            <end position="2904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2970"/>
            <end position="2980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2995"/>
            <end position="3006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3025"/>
            <end position="3042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3065"/>
            <end position="3076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="3573" mass="395541" checksum="F71101630529E037" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8V8</accession>
    <name>A0ABR3V8V8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000230">
        <property type="protein sequence ID" value="KAL1838213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF32">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50367" checksum="3B67EB20593F04D5" modified="2025-10-08" version="1">MAASTSVQAGNGPVPLTSSIPPCVYQPNPVEAAADLDTFRKYYLIFLPFVYLPSTMTSEKLRETYPFLWFTIMSVTCKHVDRRLAMSDAVKRFLAQKMVVDHEKSLDLLLGLIVILGWTHYHIKGDKPVLSVMASLAKSLVFDLGLNKVPSEPYISACLKTPFHPPAREKTQEERRAVLACFLLTSQISYALKRLDALTWTPHMDECLLALTQHREWDGDDLLAAQVKVQLIVEQLTRATAQSPDGVPPNYVLSALRSQLQSHKAQLPPHLQQNDTILSAISYADLAIHELSMTRPGPSPMPTSLMRDMHRYEAMSASLAAASDWFDRHFSIPSYVYVGMTFGYWWNMAHCLLTLYRLLEAGFQEAATARRLAAGPTVEEDCFGKFAKFARSMRGSWGSELAATGQSGGRGAAAAPVGDVVVNNGGSAEGLCMTFLQPDDSEAWIAGLFDMNWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8X5</accession>
    <name>A0ABR3V8X5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000229">
        <property type="protein sequence ID" value="KAL1838228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="757" mass="82133" checksum="0DDF42E1C91F6D22" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8Z4</accession>
    <name>A0ABR3V8Z4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000231">
        <property type="protein sequence ID" value="KAL1838191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="4">
        <location>
            <begin position="516"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="744" mass="82816" checksum="8FFBB4853BF3BBB8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9F1</accession>
    <name>A0ABR3V9F1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="198" mass="21435" checksum="8A13C8E41E62E03A" modified="2025-10-08" version="1">MVVGSILGGTVLPLEADVLVDNQVARARVDGGRDGKGDDDGWFAGTSTTSMSMTYVDEQCIAVLPVYRGAGGSYSPRGYNSGGTDLMRARRRCETVCAVGFAKLIKDSGQPRSDSPLSLSFTLLGQCQFSRFGIVEAQLAFTYQPAPPSVSWVSPDSLTQSIKTGAERQATHRNRPHQASRGAEHGPQRPRSEHFWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9G3</accession>
    <name>A0ABR3V9G3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000215">
        <property type="protein sequence ID" value="KAL1838422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046972366" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="64" mass="6706" checksum="DCDC2AAC229AD80C" modified="2025-10-08" version="1">MKLTAATLFALVAAAVAYPNPNVQPRQANIVTLDASTPAMSDGGLPQPFDSVKVAELQRRGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9N0</accession>
    <name>A0ABR3V9N0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="1">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000212">
        <property type="protein sequence ID" value="KAL1838475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="31"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="607" mass="68250" checksum="60C849FD2719B460" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9R2</accession>
    <name>A0ABR3V9R2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sialidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19135" checksum="4FD0C90CE2B5BB03" modified="2025-10-08" version="1">MQNQPGNLLVIDDDLPFHDDIDSEGRTIGLQCTRVYQLPSGALLAAFSSHDGRHARITVKSSFDTGKHFGEPSLVVVSDQTISPKFSMIVLPKSPDAEHRNVSNEDADGTVIVAYLEAMAGGHFLSRRTDVVQIIQSDDGGRTWPRHDKLQLTGSASVLFSPILYVPPGRDEIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Z5</accession>
    <name>A0ABR3V9Z5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000227">
        <property type="protein sequence ID" value="KAL1838256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="367" mass="40446" checksum="60EBECF4E0813CA3" modified="2025-10-08" version="1">MRFRTDLKNVKTFSKLVAALNSLEKIAWVRLDDDTARFTVIPDTGSQVWASLSADLIFDNYNIQSAEPNNTINLELPLGPLLRALKSASGSSYANLRLTKKESLPMLSMTIHTMTKDDTDKVRGAAAGHGYNGADLDDPNNNPFHNDPDLLFPQEPLELTLRREREKIITQDIPVRVLHPDTVETIMQPRVREPDVHIVFPPLLQLKAISDRFTKLAATASSSSSSLSGPGTFFPSTSGGGSASRHPKLLLSANMHGSLRLRLATDALDITSVWTGLENPDLDASNLPMPPEEHPSARFRAAGPDKWATVRLDGKDWSRVLSVGRLEGRVIGCFADDHALILYVYVPHTDDMTAEDVVTYYITSYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA73</accession>
    <name>A0ABR3VA73_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000209">
        <property type="protein sequence ID" value="KAL1838525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12144" checksum="3C0743595EF36F16" modified="2025-10-08" version="1">MAEATITEDSIKAALIERLKATHVEVQDMSGGCGQAFTALIVSPEFSDKNSLKRARLVNAALKDEIAQIHAWSARCQTPEEYSKEKGESSSKQEGPGVPLDGTKGGRVEGVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAH5</accession>
    <name>A0ABR3VAH5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Activating signal cointegrator 1 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="294"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="518"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1156"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1364"/>
            <end position="1574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2001" mass="225428" checksum="A4D7206478012023" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAT2</accession>
    <name>A0ABR3VAT2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000200">
        <property type="protein sequence ID" value="KAL1838667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="633" mass="68790" checksum="E68DC59B899044A4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAW6</accession>
    <name>A0ABR3VAW6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase family 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000185">
        <property type="protein sequence ID" value="KAL1838917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047444974" description="Glycosyltransferase family 2 protein" evidence="11">
        <location>
            <begin position="18"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="67068" checksum="12FD8ADC5F31BDD1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB45</accession>
    <name>A0ABR3VB45_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase organizer 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000177">
        <property type="protein sequence ID" value="KAL1839064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="131"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="39717" checksum="A8748BE344FDD6B3" modified="2025-10-08" version="1">MAQQPPPRFPSRPVAQLLGSNGPVHALAYSASPGTYILTGSSDRSIRLYNPSSTNPVVSSNCITTPRNSNDRPLPSGKLIQTYTSHAHEVLSLAVAPTNATFASAGGDRAVLLWDVITATTLRRFGASSTAHSHTGRVNAVCFAGSSNGDDLVLSGGLDGTVRVWDARSSNPKPVQVLTEAKDAVTSLAVGTAGSAADAEIVAGSVDGRLRSYDVRMGRCVADTFPASVTSVCLARDGKTVLVGTLDNKVRLMDRRDGSCLRAYEAGARKNEELRVQCVLGGGERFVVAGDEMAGEDEGSGGGGKNEGRIWAWDLLTGKVVAKVPVPWGSGSEARRKVVGRDGKEKERKNVVSCIAWKDGGFGDQFCAGGTSGVVTVFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB85</accession>
    <name>A0ABR3VB85_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000182">
        <property type="protein sequence ID" value="KAL1838978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="9828" checksum="8F53DAE313A3AEBC" modified="2025-10-08" version="1">MAEAIGVVASGIAVTQAARDLGKLAISMRDLWREIGDVPTTIDHMLKQLEMTAKFIEVVGATATASGGPAAGSVKIVLDLAIKSCSQQKDETCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC10</accession>
    <name>A0ABR3VC10_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000162">
        <property type="protein sequence ID" value="KAL1839345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044985202" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="206" mass="22274" checksum="644F300D89C0D0A9" modified="2025-10-08" version="1">MLIKKLFAAASLFLGAGLMMAEGVAAAKGPKITHKVYFDIEHGDEPLGRIVLGLYGKTVPKTAENFRALATGEKGFGYEGSTFHRVIKNFMIQGGDFTKGDGTGGKSIYGEKFPDENFKLKHTKKGILSMANAGPDTNGSQFFITTVVTSWLDGRHVVFGEVLEGYDVVEKIENVQTQPGDRPVKTVKVAKSGELEVPPEGIHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCH1</accession>
    <name>A0ABR3VCH1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000176">
        <property type="protein sequence ID" value="KAL1839086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="334" mass="37141" checksum="3A44D405A9959EA6" modified="2025-10-08" version="1">MPPTKKRKTAHNNEASAIADQPAEQDQIMAPAGESTTDETAENATDKGATPKQNEKTASAEPSPPPAAAEASSSSTTPAPVPSTAAATAQDRLARFRALQARAKESSHANLKEATKESQRLATDPSQLSALQRKHAIASHKLLKAEVEEAGEDFERKSAWDWTIEESERWDKRVRKKEAHRDDTAFRDYARESEKAYKRQLRNMGAPDLERYTREKFAAIERAAAAGTLDIIETEDGEMIAVDKDGTFFSTADSTAFAQHQPDKAAVDRLVADLRKAEEASLKRRREKMAKNAEESGDVTYINEKNKQFNQKLARFYNKYTAEIRESLERGTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCK3</accession>
    <name>A0ABR3VCK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1394</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000150">
        <property type="protein sequence ID" value="KAL1839573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="262" mass="29188" checksum="28BC0719A7F9F2C7" modified="2025-10-08" version="1">MSELMDAYLAQPPIARTLTTAVFVTSVSVHLLGWLPATWLYFDTEFLFRFPPEIWRLVTSFLLSDPQLGIIMDSYFVFQYLKQVETANPKFTTKEDVVWYLMTVGSFIIFINRVILGSGAFFLPGLIMALTYTACQDQRGAQAGFFFFTVPAQTVPYCMILMSFLMRPWIIPMQISGIVAAHLHDFLWRLWPEFGGGPRILATPSFVSYLVQTPRNLNRGYGTAIRPSGSGAGTGRTTGASTGSVLPDSWKTRGAGHRLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCN8</accession>
    <name>A0ABR3VCN8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-ornithine N(5)-oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000155">
        <property type="protein sequence ID" value="KAL1839464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="2">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="111111" checksum="A954460488D624ED" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCU7</accession>
    <name>A0ABR3VCU7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000156">
        <property type="protein sequence ID" value="KAL1839455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="419"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="525" mass="55745" checksum="AC125BE27D3C6629" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCW2</accession>
    <name>A0ABR3VCW2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000149">
        <property type="protein sequence ID" value="KAL1839586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="50289" checksum="3FE730425A132B09" modified="2025-10-08" version="1">MSIPNVPDLVSTFVANGTTPEPGTGAGCRRGLGITSGRRGRVPATDPLRGMFTHRLHSAPGREEQGVPAGSVSAEVSEAGVHSTESKVTAATAAWKGAIGRFGNQNSACILQDMPNYEGTGDRTGPGSTSKSKLKSASTTKPQKENDATGNTGKKQRQQGKKRDPEATMSKLSPSLKALINAPFARPGQSPAPRHMRDVYARIAREATERRYGHRPWITLSAAATITLNSPSSLLILHSIASQSPSPTLTPLTTYELLREIALKCISFNGIPRTINTLAEFRAGLAHEPWFSSVCTTPTRQVTPSNADAITARARQLWTSIYTPFDEKLEVKLAESHPDLPVHILSSHYGPLLSDPEGDRGGLATVGRTLTSIVAIACLRAQTGVGPQVVSHVFGLRKGVEQGAHKEEFKEVVGKEGKEREVEEEAEGVERLATDEGSEWLLRSVDAIAEAIGTEGGGFGRWEEGGRGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDI2</accession>
    <name>A0ABR3VDI2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000134">
        <property type="protein sequence ID" value="KAL1839934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="82"/>
            <end position="103"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="156"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="188"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="457"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="506"/>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62624" checksum="F7FC152CA3F7D535" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDI4</accession>
    <name>A0ABR3VDI4_HUMIN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 620.91</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1839191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <dbReference type="EMBL" id="KAL1839191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="159" mass="16907" checksum="8C7949F6D592BB00" modified="2025-10-08" version="1">MAGSALQPDTHNALDPAINTAYHGVQAEAQAASSSTHGNEVAPQRSAACQRALNVIYPFVGKSNATRPLQTGASNGNCGVRCRPSHFRPSRSATLLRSCTSTTRLGRMKCCEVLGRDSQLCVSPSAMHVHARGRVMAWRCPVCPLLTFTSLTVSSGRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDS7</accession>
    <name>A0ABR3VDS7_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">HAD-superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_1019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CDP-alcohol_PTase-I"/>
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        <property type="entry name" value="HAD-SF_hydro_IIA"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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            <begin position="97"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59855" checksum="1CA34C17ACCC4DF5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDY2</accession>
    <name>A0ABR3VDY2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase group protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000135">
        <property type="protein sequence ID" value="KAL1839917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="80662" checksum="29C1F6372D51F3C1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDY3</accession>
    <name>A0ABR3VDY3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="146"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="243"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="338" mass="37171" checksum="635B91142E340354" modified="2025-10-08" version="1">MAATADVNPSPAAPEPAPVQPQTSSVGSNYRGFVAGVFSGIAKQTVGHPFDTIKVRLQTTASTRFSGPLQCLAQTVRNEGLRALYKGATPPLVGWMFMDSVMLGSLNVYRRLLHDHVFAPRRATTTTSSSTRSNAHNHSANTAIDLPTYGHGLAGIAAGATVSFVAAPVEHIKARLQTQYAARKADRLYSGPIDCLAKIYRTHGVRGIYKGLQATLIFRSFFFFWWGSYDLLSRFLRERTSLSAPAINFWAGGLSAQVFWIMSYPSDVVKQRIMTDPLGGALGDGERRFPRWRNAARAVYQEQGWRGYWRGFVPCFLRAFPANAMALVAFEAAMRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE11</accession>
    <name>A0ABR3VE11_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable Xaa-Pro aminopeptidase P</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_991</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000134">
        <property type="protein sequence ID" value="KAL1839947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="10">
        <location>
            <begin position="325"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="12">
        <location>
            <begin position="555"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="617" mass="67687" checksum="59CB87546A47D74F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEB7</accession>
    <name>A0ABR3VEB7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000124">
        <property type="protein sequence ID" value="KAL1840162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="152" mass="16341" checksum="F6F470BE747BC565" modified="2025-10-08" version="1">MVIVRESIAVDWWPWLHANGVGLVGTESNASVLVCRSWCGDVSCVCRQLSVVVAAAAACSLLSFFCLSSLPRLHLPCLLAFIPLFSFPRRVSSWCRAETGLDGLELTSKSGMVQGDGGGYRRGGNLPRYPQRLTPGLPSLSGRVLLLYSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEP0</accession>
    <name>A0ABR3VEP0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000142">
        <property type="protein sequence ID" value="KAL1839733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="91"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="300" mass="32543" checksum="DAF98140FE30A297" modified="2025-10-08" version="1">MAAAEKTAAWEKQVQRNPHPDFKTVEASRPPFPAATTFHYTQTPDPNWTFGAGANATLTPEDRAKGHVTIDPHAPGRPAAFNYKLLISAVVPRPIAFLSTRSADGKTTNLAPFSYFQMIGHDPPLFIVGFATPAGTGVAKDSLRNLRESGECVINVVSEGFVEAANATSVNAPYGVSEWDVSGLTPVYDCETVGCARVREAVFAVEGKLESLKEFESRANPGRIATTLAVIEGTRFWAREDAVNEERTMIDPKVLRPISRLGGITYGRVTEGLELPRPDFEKDVGGAEGMDKLKNKQQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEV8</accession>
    <name>A0ABR3VEV8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">VTJ49DRAFT_734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000124">
        <property type="protein sequence ID" value="KAL1840160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="40"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="495" mass="53832" checksum="734FA0F52B71F279" modified="2025-10-08" version="1">MDALARSRGAYVCRSCTRSLRRQWLRAHTYSTAATTPDIYDVVCVGGGPAGLSLLTALRANPATTHLRVALVEAQHLSKVRTWKLPPDRFSNRCSSLTPTSVRFLDSIGAWKHLERDRVQPYHEMQVWDGVTGARIEFDWGLGAAPSADAIEGTTIAYMNENLNLTSGLLKRLDELGGVAVFDGAKVEAITYGPETEELDLRQWPLVHLSSGNQLCARLLVGADGANSPVRSFAGINAPGWDYNRHGVVATLEMEGDGWRGDQVKIAYQRFLPTGPVAMLPLPGRFSTLVWSTTPANAAVLKSLSPKDFVAMVNAAFRLSPTDLTYMHTQEAGQTDEYSWRIQHTPHDPRAVPQEVVAVQEGTIASFPLRLRHADTYIAERVALIGDAAHTIHPLAGQGLNQGQGDVQSLAKTIEYAVTHGQDIGVTMSLEPYLAERYAANHVLLGVCDKLHKLYSASSGPLVPLRSVGLSAVNALSPLKSFLMNRAAGNPLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEX7</accession>
    <name>A0ABR3VEX7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000119">
        <property type="protein sequence ID" value="KAL1840304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="109"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="340" mass="36729" checksum="F4D2F8891E57372C" modified="2025-10-08" version="1">MSSPSKSVFGSLRDKMTKKNRTPSSTPKSNPTPWGSIPASDAQQSLFPQPTDNLPPPPPYSPVAPNPPVSSRLGGDLNPSLSYTPPQTRPNRFIAATAEDPYAFLSSFDTIFLIDDSGSMAGQSWREVQQALRSIAPICTAHDANGIDVYFLNARNTSAATHDPAQGWHNITTPQQVESLFSRVYPGGATPTGTRINQILRPYLREYESAVARTGNPDECGVKPINMIVITDGVPTDDPEGVILSAARKLDALDAPSHQVGIQFFQVGCEPGAAEALRELDDGLSSRGGGRGGVRDMVDTVTWDYRHSRPELSADAILKVVLGAVVRRLDRRRLSREGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF53</accession>
    <name>A0ABR3VF53_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000118">
        <property type="protein sequence ID" value="KAL1840328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="120" mass="13564" checksum="93A2D0DFC317F817" modified="2025-10-08" version="1">MPTKVPPTGGWGLGIDRLAMFITNNYSIREVLAFPFLREEKQHKEKFAAEIVDVQPLPEEGICECLLLIIVGMSTWLTVGLQTINRGSLGDIGRNKCWVRAGLEFELFVEVHRCRHGIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF89</accession>
    <name>A0ABR3VF89_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000116">
        <property type="protein sequence ID" value="KAL1840367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="239"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="497"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="550" mass="61515" checksum="68E2137729F1EA0D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFH1</accession>
    <name>A0ABR3VFH1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="9">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PIM1</name>
        <name evidence="15" type="ORF">VTJ49DRAFT_326</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000108">
        <property type="protein sequence ID" value="KAL1840552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="185"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="896"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="286"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="814"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1094"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="814"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1094"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="988"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="1031"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="600"/>
            <end position="607"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1840552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122670" checksum="5D8D3CF4A3A2E4F3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFM6</accession>
    <name>A0ABR3VFM6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000110">
        <property type="protein sequence ID" value="KAL1840502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
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        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="7">
        <location>
            <begin position="985"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="820"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="936"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1154"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="827"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1197"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1580" mass="178288" checksum="27849A26037C2928" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFY1</accession>
    <name>A0ABR3VFY1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyruvate carboxyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000110">
        <property type="protein sequence ID" value="KAL1840505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="232" mass="25116" checksum="FB35023EC41D5878" modified="2025-10-08" version="1">MTPSLGISWAFANYLQLVRTLRGVVSCDIETHFHNDTGCSIANAFCALEAGATHIDTSVLGIGERNGITPLGGFLARMVVSAPEYVKSKYNLKMLKEIEDMVAEAVEVNTPFNNPITGFCAFTHKAGIHAKAILNNPSTYEILNPSDFGLTRYVHFASRLTGWNAVKTRVGQLGLSMTDDQVKEVTAKIKALADVRPIAIDDADSIIRTYHLTLNPETAPQDAAPVEPVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG50</accession>
    <name>A0ABR3VG50_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF68">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="334" mass="36495" checksum="34C183B9E0D220B9" modified="2025-10-08" version="1">MATTMVTTHYAPQHYGYMPPPSPPMDETTKCSLPSISNLLGLADQGSPTSETSPQSQQQQQQQQQQQQQQQQQQQQQQQSQQQSPSYKSDTRSDSQYASPALIRGGLPPSPPTTSEASFEGFNSPPTRSLSHVSTGSNYYYETTPPLQVDDSRQMNASSTVPRVAVQNASTYQPQFGSSAYMSPPSMSSYYPPMQTATAAQPQVSGLYYQRPLPQVFPPMSLSVGLPPAAGNPWQHHHYIAPSASTSFPQSQDRYICKTCHKAFSRPSSLRIHTHSHTGEKPFKCPFPGCGKAFSVRSNMKRHERGCHNYDSSSTGSTAAPATTTSTGPSRPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGF8</accession>
    <name>A0ABR3VGF8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000093">
        <property type="protein sequence ID" value="KAL1840939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="162" mass="17651" checksum="6FF3D4738EF35D29" modified="2025-10-08" version="1">MASGHFEVKKFIMSESTWTPPKFGSPVWLGISAKDVARAEAFYTTVFNWTIKASPRKPEQSEIDAATRLVDWNPDVKLSGGIVPRPDGDNPTAQPPPGPGGVVLYWFVEDLTKTAETIERAGGKMIGSKEPIKEGDAGLYRFFEDTEGNVGAVYQLVSNKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGK2</accession>
    <name>A0ABR3VGK2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF10">
        <property type="entry name" value="TIP ELONGATION ABERRANT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="52775" checksum="9219749DC39D0E4E" modified="2025-10-08" version="1">MDEAVTILAPGHPLKLSLTQLSIPVPSETLHPALARSHHTLTVLSNKAFIFGGLDASGTLCPPGIHTLTLPTSETTPNPPSTTTTTTTSADPVSQESTATPTSSYYTSYPPYTLHDETTGELLLPRARSGHAACARGRDGRFLFVHGGRLAERNNDNPASNNSAGENDEKEDEDDDDESNCLWQWDAELLRWSRLPGETQLGESMAAPRWGHWIFWDRDEGDEMNTAGFVILIGGRTAGAGTGFSEHEHSHTERQAWMYDLYTGAWTALPALPARPLAAAYVDKRVYVLSRAGEEGVSAATTAVHYLDMQESAVEREKFRALVWKTVLPNPHSHGHGHGQSPGPEPREGGALIPLTTGHGREYLVYMFGCSTTASGEKKFHSDIWTLQLPAKKHSLAAAADKFRETFFSHGDTGVFHWAEAEIVPTEQGGGEGKVLPGPRAMFGADRCLNGRGVVLWGGVNAKGETESDGWLIRSAYGYADHERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGK9</accession>
    <name>A0ABR3VGK9_HUMIN</name>
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        <recommendedName>
            <fullName evidence="3">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
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        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="206"/>
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    </feature>
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        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="3">
        <location>
            <begin position="200"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="560" mass="60947" checksum="CDF85036012CDE6A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGP3</accession>
    <name>A0ABR3VGP3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="61249" checksum="69AFB0264C8AB6B7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGU3</accession>
    <name>A0ABR3VGU3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 93 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF1">
        <property type="entry name" value="BNR_ASP-BOX REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047287460" description="Glycoside hydrolase family 93 protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43579" checksum="8D073D37B44444A0" modified="2025-10-08" version="1">MGLSIKTLFSLATAAGASLAAARPPAKPSPFFVNHPIYTPPEGVRIMYPRASELRDGTLLVTANVFGGGNFFAGPDGNLPAFPVFASKDGGITWKWISNITDEVNGWGMNAQPALLELRKPIGGYKPGTVLASGNSWSANGTRIELYASTDKGRSWEYVSRVTEGGRPNTTNGADPVWEPFLLHYEDELIVYYSDQRDPKHGQKLAHQRSKDLKTWGPVVNDVAYYDEYLARPGMTVVAHIPPIKKWIVVYERPIGNSSSHGANYPVHYRLADKPTEFDTGEEFPIVIDGNFAPNASPYVVWTPWGGKNGTIVVSDADNGDVFVNQRGGDPDAWKRVVTGQRDAYSRALHVFEKHPERLAIIGGDTFNGSDFELTIGVLDLKKLLGQDKPKPGKPGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHG2</accession>
    <name>A0ABR3VHG2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046591">
        <property type="entry name" value="DUF6649"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20354">
        <property type="entry name" value="DUF6649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="323" mass="35705" checksum="902210B95EB3885B" modified="2025-10-08" version="1">MLDHRYHHQHQHPHFDHGAFPAQYQHQHNNQQQQQQQLEAPLLRMQRKRKADAPPENNERLSKRMSLLNLGMRPPFHWSQPIVAYASETGNPQLTLSASENSGQKLYVPVENPDFQAATAAAASTADAAKPKKSHRTRAPVDDSVMQLDDSKYKVYIYNLDDELSSSDNESDTSSSADNSNNTNGKLVFLPDIEKHLRANRIPTRVLQDPRPDPRAELAGKELVLYSVPTSLSVPAEQDSVRKAIIEARARARERQKAELEMAAAARKGMMPTPATPAPAPSASASSLGTSHGVMAMDAEPLMPPPPMPTPVVEDDPDAMELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHV2</accession>
    <name>A0ABR3VHV2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maintenance of ploidy protein mob1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15298" checksum="5CD4C13561203E1C" modified="2025-10-08" version="1">MKATDEFEYLWQDNENYKRPTKMAAPAYIEQLMTWVQGNIDNEAVLPSRIGVPFPKSFPALVRQIFKRMYRVYAHIYCHHYPVIRELGLEPHLNTSFKQYVLFIDEHNLASGKDYWGPLGDLVDSMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHZ6</accession>
    <name>A0ABR3VHZ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1840736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="152" mass="17223" checksum="4B651D8DA057D47F" modified="2025-10-08" version="1">MSASLFRVAARRTSGLLRAAARPQPVVARAAVAAPSFSTSARMRAEHQEETFEEFSARYEKEFDNVQDVFELQRNLNNAFAYDLVPSPAVLSAALRAARRVNDFPTAVRIFEGIKAKVENKTQYEQYLEELKPLREELGVVLKEELYPEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Soft-rot fungus</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1841429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="162"/>
        </location>
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            <end position="309"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="345"/>
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            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="345" mass="38084" checksum="BEB5D60714A623A9" modified="2025-10-08" version="1">MTASTRSAIGTGSLSRCRPSWAIRRVASTLTSASVCFPILSFRLILINSPLTEPAEHYFQNTCLGNFSPNVGKLHKRYFKFGKSPVAVELGGTHQQTNANLSEQELKAKHAAARLELEEKKKAAAKEEAKEETKESMKKEDGSDTATDTDMTDSDYESDSKDSVVDIKTEVKEMKPVVKDGDDKSFVNVKTETDAASTATLVSTSVGAQAFLVLTPPATLTATTAEGTTPCPNCTGTREDPIIMNCQYPTMPSQPIHTHHPTPQFPAPVARTNFCRTGDQRPAPHHYHHNENRYQRPSYQSQANRYHSMDTEDKNEGLFVAQPPASWAHGRAAPHGDDYGHRRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3VI85_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
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        <name evidence="3" type="ORF">VTJ49DRAFT_6782</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="429"/>
            <end position="517"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1175"/>
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            <begin position="1"/>
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        <location>
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            <end position="20"/>
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            <end position="34"/>
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        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
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            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="610"/>
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        </location>
    </feature>
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        <location>
            <begin position="879"/>
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        </location>
    </feature>
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        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <end position="1030"/>
        </location>
    </feature>
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        <location>
            <begin position="1047"/>
            <end position="1072"/>
        </location>
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        <location>
            <begin position="1153"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1844245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1195" mass="128082" checksum="FFE2FDD91D7EF073" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VID3</accession>
    <name>A0ABR3VID3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="common">Soft-rot fungus</name>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF6540"/>
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    <dbReference type="Pfam" id="PF20174">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="236" mass="26036" checksum="B14C5B9E19905CBA" modified="2025-10-08" version="1">MASSNSQAPRYYEVYLLRFELGRFTDPDMPAPRYHNLLFVRCNPDGSGIKFHVTGDITSSTGMIYKSEAYHDFRYSRTLYDYKLLGYTPSYNFHARWDAVLNATEKPPQQKAFNIATMKTEPFKTLHPLTFYQPGEQRRPLWKCTEWTNYKAIPALKAAGLIVTEPSPSPSPPGSRPGSRGSAAPVGSRPASRGSAASAGSRPGSRGSGSAACNGWQRSVWRDTGGPLADWSANFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIQ6</accession>
    <name>A0ABR3VIQ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="8">
        <location>
            <begin position="120"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="341" mass="37317" checksum="6F08AAD2785F2191" modified="2025-10-08" version="1">MSDSPVVPETRVLAVASHVVSGYVGNKIAVFSLQSLGCDVAALNTVQFSNHTGYRQWTGSRVSAEEIIELYRGLKQSYLDDFDMMLSGYVPGAAALEAVGRIGEELKRKAAAQGKPGSFFWVLDPVMGDNGNLYVAPDVVPVYKSLVPHADLVLPNQFEAELLSETPITSMSSIGHAIQVLHERYGTPHVVITSVSLPHPDHPVSSLSVVGSSMTSDRRARPFKIVFPAIDCYFSGTGDMFAALIDDDVDALDLPLARAAEKVLATMHEVLTKTAERMQETVEKARVELAKAEVDGTERASNVEDEKKRMHLLKSKAAELRLVRHLDSLRFPKAEFRATRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ80</accession>
    <name>A0ABR3VJ80_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31138" checksum="566D9E03F46BE3AC" modified="2025-10-08" version="1">MQFLPGQWVDLYPPQDTGITKPGGFTITSAPSLASHSSSNPYVELAIQHSPDNPVAAYLFRPVEQLLRTPVSVRIGGSFVFPPPLAGPAPLRRVVFVAGGMGINPMMSMLSHIAEPGMWREEDRVRFRDLEVRLLYSVKDPVVSVATDAASGGNDGGVAGGGRSRGGSDRDVVDSRGVLFLDRIAELFGTGRLKGGVQLFLTGGGGGRPLPTTEGPTPPRVFARCDAGDVPVLKRRITVRDVGEAIGSDKDSTVVYICGVPTMTDEFVQALVSPDDFGMEKNRVLFEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJC8</accession>
    <name>A0ABR3VJC8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047208233" evidence="3">
        <location>
            <begin position="25"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="705" mass="77238" checksum="7DEC7D302EB9B293" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJK8</accession>
    <name>A0ABR3VJK8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="326" mass="36248" checksum="445F3F7726330A3C" modified="2025-10-08" version="1">MAAVYATMHPQDELAALFSRNLTLHPAPPPAPEPAPAPTQAADPQPQAEQKIVYISAHYHHSAHLANKSEPQSPPRPASEPSQSEVERVLREHGVDPLNLSPAQIQLFKTLDTPFQLRLVEIWRACPPPAPSGPNTDSLNPTTFEQEEGLARLRFEQQQQQLIDQQLQQEFFSGGNDSMMQDDETVLSLDGTPLTPTTMQASDGRWVGVGSPSSPSSSSYYCQSNQYSYMEPYMVEGYGEELMRREYHDQQGQKQLLEQERQARGNVDEPRAEAVPALQETLKAHADSAAPAGGSPNFNPAHADPVYRMMAERYGWFVATRDEEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJL8</accession>
    <name>A0ABR3VJL8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="6">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="408"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="468" mass="52615" checksum="6BC5D50DC6F71D45" modified="2025-10-08" version="1">MSLRGLQKGFARAPQQIKAKFNIGEHTKDPIYIDSERRFTDLETETKRLHDESKKYFDAINGMLNHQIEFAKAMTEIYRPISGRMSDPNSLEIETSHEGIRACEEYQSVVKELQETLAPELEMIESRVIQPANELLDVIKVIRKTVTKREHKKLDYDRHRAALKKLQDKKDKTAKDEKATWKAENELEQSTQEFNYYNDLLKEELPKLFELEREFIQPLFQSFYYMQLNIFYTLHERMQQVDIGYFDLTLDVEEAFIKKRGDVQERAEALSIVRFRTTGQKRPPKYQKKPALEGPKTAGLLTAGPSADSDAASTSSFSPSSSAAAAKLPASAPPTVSSLRPSWQRQQADDVEAPPPPYTPSASTKPAFSAATKPAISSGSASLAAVAAKKAKPPPPPKPKPMRLSAAPKVETVTALYDFSAQAEGDLSFRAGDVIEVVQRTNNENEWWTGKLRGKTGQFPGNYVKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK05</accession>
    <name>A0ABR3VK05_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spermine/spermidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="65637" checksum="99F4BDB04FD3536A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK19</accession>
    <name>A0ABR3VK19_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="152"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1192" mass="128489" checksum="6A73274ADB66B0C8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK74</accession>
    <name>A0ABR3VK74_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046502953" evidence="1">
        <location>
            <begin position="24"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="346" mass="35944" checksum="32B9E7C5117B61D4" modified="2025-10-08" version="1">MIKSGLGYMWLLVTLLALRASAACTSFGVDYASGGTYSIDVTSNEYFAFTTVFQGCSWEAIRPILVGPDDNLYACSEITTEPNGVQVKSTCGIPYSAMRSGRWKIILSGNQLSAQRTLNLVVGLPQTTWVTVTPTVVVGVTTTARAQTVLTTVLMTQTVIGAPRTTTIPCAGVTRTITTYLPGSTSTVTSIAVRTVTTGTITTYWTTTVTATASCHLPGVSLGAARVAAAAVTPAASVASVTSTVTASRAVTSTLTTTVPGTTTTELVLRTTTSTITPPPLTVCTGAGRDTTVTVTSRNGVPVTLTDIIYLTSHLPATVWVGQTTYTTSTNSASATACWRSGGWYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKF6</accession>
    <name>A0ABR3VKF6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="617" mass="66236" checksum="A0E5CC7AC396FD4B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLE3</accession>
    <name>A0ABR3VLE3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="253"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="732" mass="80478" checksum="92BD257D4304F6AC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLS8</accession>
    <name>A0ABR3VLS8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000033">
        <property type="protein sequence ID" value="KAL1842764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="388"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="728"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1230"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
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            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1230"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1251" mass="137970" checksum="BD1C2215C2CA3217" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMI6</accession>
    <name>A0ABR3VMI6_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1080" mass="116603" checksum="18ABFAAA36E38DD6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMJ0</accession>
    <name>A0ABR3VMJ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="2">
        <location>
            <begin position="82"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="251" mass="27086" checksum="D53C9CE6AEF47B6F" modified="2025-10-08" version="1">MANPPLTRALTRHLSQHLRRTSTRGQPIRHSSTHPSPPTQHDPFTLLSKPTWSVRQLLDPPTTTSQDTTTTTTTTTPPPQQPPSQEEEEITEQQLHHLLRLSALPPPSSESETSSLLSTLRAQLRFVRAVQQVPGASSVQPLAAIRDETAAGMREAEISLHTAGVKEALEQEEIWGRCRRPRRRRRVVGETGTGTAAEEKAAGEEWDVLGMATERVGRYFVVRSGGSGSVKEGGGNGKEGGSAASAAAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMT9</accession>
    <name>A0ABR3VMT9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="548" mass="62114" checksum="63F00DCE1677331F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMZ8</accession>
    <name>A0ABR3VMZ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_2387</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047286592" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="25"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="24"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="756"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="943"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1114"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1606"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1729"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1611"/>
            <end position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1843278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1751" mass="190607" checksum="2B59AA8E6DC9C018" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNB1</accession>
    <name>A0ABR3VNB1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="365" mass="40953" checksum="5FFD0E8B316CAB71" modified="2025-10-08" version="1">MEGLLFNVNNGYIEGIVRGYRNGLLTGTNYANMTQCETIDDLKLQLGPAYGDFLASLPPNPSTSSLAAKATDKLVSEFRYVRANAVGSLAQFMDYVTYGYMIDNVALLITGTLHERDTRELLERCHPLGWFETMPVLCVATNIEELYNSVLIETPLAPYFKGSLSHQDLDELNIEIVRNTLYKNYLEDFYRFVNTHPDMAGTPTAEVMSELLEFEADRRAINITLNSFGTELSKADRKKLYPNFGRLYPEGTLMLSRADDFEGVRLAVEGVADYKAFFDAAGLGGGPAGPGNLAGGAGPEGRSLEDMFYQKEMEIAKSAFTRQFTYAIVYAWVKLREQEIRNITWIAECIAQKQKERINNYISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNB2</accession>
    <name>A0ABR3VNB2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sulphur transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="35033" checksum="9B728207FD434D0D" modified="2025-10-08" version="1">MDNTLSGVAMGAALTTAGVYSPDIILSQFKFSDFTMLQTFLTAAAGSTLVVTLSQALGLTQLPPRSATSLGLLPTRYDGNLIGGALLGAGMAISGACPGTALAQLGVGVRSGRWAFGGAVLAGIVWAGIQRRQRQAAAAEKTKKQAAATDKDTTEPSLTTTTTTTKPCPSGPSLDTFLGTSKPAAATVLESTLLLALFALSRLTPATAALARGVPPYLGGLAIAAAQAISLVLRKTPIGASSAFEELGWYFYPGAARKYTHLLFSAGLVGGAWLAAQAFPTLRPVVEVAVSPVRSVVGGFLIVFGARIAGGCTSGHGISGLSLMSVSSFVTVAATFVAGGLVGLVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNJ8</accession>
    <name>A0ABR3VNJ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="830" mass="91591" checksum="AB3498B64D93AA23" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNV2</accession>
    <name>A0ABR3VNV2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="499" mass="54322" checksum="B22FD2B15D45BACB" modified="2025-10-08" version="1">MDSKYFTSSPAAAKRLFAEEAQDSPSSKRAKRSRLSKKHQFKSIKTENDAGFEEDWIPDADTSVFASSNRALKTEKNNDTNSQKGIGDGEQNTGTSVSPADSTTQDGNKLKAEANTRKARADSRAANNVKSPGDFSVGGRRHPISSSTPAVAGPSHPRSENGHTAHKTEKEEYIPLSELPVSPLRDYTFKAFPDPKPLQYGAPSSLSSSSKKGKKKRGSVSNGVFLEKDEATAFPITAVPPKTEEMKTEKQKKKRKDKKNDEKKDEGAEMKDQDEEPTTPPALLTDDKILAAPAGTRTLKAISKHLKAISTKLDESRQWSVDLKAKANFLTSSEGSKLTVPEDLATTSTGIPAATIEALRRDLANLQSRVDLADLRASIRHEVLFSALLKVASDVSDLAQTVKKNHRQHMDDQVRLNSAANGGADPGIVSDADIENPKQAAATAAREKRAQMLQTSRKTYEQCLRIYTADMDRATSKEEVVNFGQLVVKYAGDLLKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP37</accession>
    <name>A0ABR3VP37_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44323" checksum="6024C3C6A5D5D240" modified="2025-10-08" version="1">MSNSKAVAKAPEAEVVPVDSAQALKACKALVAHIKKAAGKPREDGKQDLLADEESTVAETPVWLTLTTKKHIHDSNRLQPGKIILPHPLNTAEDVSICLITADPQRYYKNVVADEFPEDLRAKIGRVVDISHLRSKFKAFEAQRKLFSEHHVFLADDRIINRLPKALGKTFYKSTVKRPIPVVLMAQRPKVDGKRVPVAKTGGKKAKRDPAETANARPAEEMVAEIRRAMGAALVHLSPSTNTAVRVGYAGWEPEKLVENVETVVRELVGRFVPQGWRNVRNIYVKGPETAALPIYQTDELWLDESKVVPDGQEAPSALPGKARPAAEKANISKKRKPLEDGPSVEEAKEPAKEEGERPKKKAKKATPLPESNDDRLDKDIAERKAKLKKQKKKAAGKAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPL0</accession>
    <name>A0ABR3VPL0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="336" mass="37741" checksum="98E18F6F997463F9" modified="2025-10-08" version="1">MERFRSLLGGGMNLGGPAAGADNTSLIDNSETVHISSLALLKMLRHGRAGVPMEVMGLMLGEFVDDFTVRVVDVFAMPQSGTGVSVEAVDPVFQMKMMDMLRQTGRPESVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVVDPIQSVKGKVVIDAFRLINPQSLMMGQEPRQTTSNVGHLNKPSIQALIHGLNRHYYSIGINYRKTALEENMLMNLHKHPWTDALQMEDFRCEGQRTKERLQRLVSLAEGYEKRVKEETELTKDQLKTRYVGKLDPKKHLEDVGQQLIEDNIVAVTRQMIDKEATMTKKEAPTETNGKLDGDEMEMEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPR2</accession>
    <name>A0ABR3VPR2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="62849" checksum="07558543CDA6843F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPR7</accession>
    <name>A0ABR3VPR7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="315" mass="33455" checksum="07785D587B9032B1" modified="2025-10-08" version="1">MTAPDGPDTQTKPPTAAAFNALHNRISLLLDQRRSLVSTSTTSSSSQKNKHLPSSSSASPTPPVFRSGSNTPSSLQQQQPISRRQLALDDDDDDFNIGRENAGIGYVPPSKANRQGAGNEAERGQPGSTTGKDGSKKDMEQQVLQKKVLGRNAARQLAEAQGKKKEKKSGVGGGNDSEDEDDVGKGALVRKRKSAVTPNVGGDVDGVRRGKKARREGGGVGAEKGDEDSSKGGEEKAQKDEEEQIKVEGGEDVVMTEAGEQAARPKAPAETQEQVVSGEAKRKKKKKNKKKKKQKQEEANGTTEAKADDDNDTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPU6</accession>
    <name>A0ABR3VPU6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045045024" evidence="2">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="218" mass="23086" checksum="96FB68689A18B07D" modified="2025-10-08" version="1">MKTTTTLLTLGALTAPVLATWPWGGDDDHPRPTLTWSPPPIPTSWSKHWTWTPKSKTTRFTTSTVYATSTLTITSCEETVTKCPGKSTVITTVTIPVSTTICPVTETDEPEEPTPTPTPTSEPTFVTKTKTKTYPPETTSSKEPEEPEEPETSEEPEKPTPTPSYVPPPPPPTKTTTKSEPVETTSAPPVVTAGAAHGKAVQKVAGALAGIAVAAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ12</accession>
    <name>A0ABR3VQ12_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="49"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="315" mass="34643" checksum="746582502404B89D" modified="2025-10-08" version="1">MPPPRRRPQDVDDEEDDSQQIIDDVDEDGDEPMEDADSGGEMSSMIKNLVRYALACEFSRTPIRRDGIREKVLGPRGRSFKKVFAGAQKQLRATFGMEMVELPTKDRSLMTTEQKRKAAKSQSQKEPTSNAYILVSVLPTAYTTPDIITPSKVQSADGEAAYIGLYTTIIAIITLSGGELSEPRLRRYLTRLNAAENMPSMNPHDATSPSEKTDIVLQRMVKQGYLVKVTESRSAGDDEGTTWHVGPRGKVEVDNEAIANVVRAVYGGSTEELEKKLETSLKIKGRNPGGDGEIEEEVEDAPPDGDPGPSNPRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQR1</accession>
    <name>A0ABR3VQR1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="560" mass="62322" checksum="2607C3B1E8AAF68F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQU6</accession>
    <name>A0ABR3VQU6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="41"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="432"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="73792" checksum="1B164674612A3F73" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQW3</accession>
    <name>A0ABR3VQW3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="329" mass="36787" checksum="FF4B616920FD34BE" modified="2025-10-08" version="1">MEANAGQLGNSASGANEADATTKKRQPPVRHPPPPGSRSPYDFHDARTPPFPYRPNQPVDPNPVLQAEHSPRVWNRVPRGPDAAGSNWTCLSISPWRDENQFDDDFSADDFSPFVDFDIVQERLDHATKYFEFFGNTTSRIPWVPAGTMATPQLLFVDGTFAELAQEIADYLQIGDSVRPFLEQENNEEALQLIVKASSALNAAPEKEFTGAYNLLIHLVLQSSDPKKYLPTVCGNLQKPITSSPAHGFTLAANALSSVFNLIDPSNPVRFHVLLQITRFLRQHGQFELLKPRLKNLETWFKDWNTDEEDQRKLYVEISEAAGEAGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR36</accession>
    <name>A0ABR3VR36_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4979</name>
        <name evidence="12" type="ORF">VTJ49DRAFT_7536</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000090">
        <property type="protein sequence ID" value="KAL1841020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="211"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1844127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="311" mass="33797" checksum="26F9EA8E20369813" modified="2025-10-08" version="1">MAQPNAEPIEDYDYESLPPNFSLMQNMAAGAFAGIAEHCAMYPIDAIKTRMQIINPTSSNIGSGVIRATYRMATTEGILSLWRGMSSVIVGAGPAHAVYFATYEAVKHLMGGNQAGVHHPLAAATSGACATIASDALMNPFDVIKQRMQIQNSAKMYRSMFDCAKYVYRKEGLAAFYVSYPTTLSMTVPFTALQFLAYESISTWMNPTKKYDPVTHCLAGAVAGGFAAALTTPMDVIKTMLQTRGSATDAELRTVNGFVAGCRLLYQREGTRGFFKGVKPRVLTTMPSTAICWSAYEASKAYFIHRNNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRA4</accession>
    <name>A0ABR3VRA4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="154" mass="17129" checksum="927CBDA84C522198" modified="2025-10-08" version="1">MAPLVEQLTAMVKRADGCGSYAYRGSDGYCHYGSSWYWWGRWVFAGLAVLFVLLVFLALFRNSRRRRKMGQQPMYGTGWMAPGPPPPPYYPPPPQYDAQDPNAYKMGSYYSGQQQGVSQDVPLQTPPNTYQPAGPSHQTDYAPPPGPPPSHVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRA8</accession>
    <name>A0ABR3VRA8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="537" mass="60610" checksum="B493538A251A5AAE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRC6</accession>
    <name>A0ABR3VRC6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3822</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="253"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1844166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="446" mass="50328" checksum="9FD26CCE92311DCE" modified="2025-10-08" version="1">MSVLIETSTGDIVIDLLVDYVPKMCENFLKLCKVKYYNFSPIHSIQKSFSFQTGDPLGPMSPQSDGGTSIWGLISGDPAAKTFTALFHPKLKHLERGTVSMATAPHPSDPDQRLAGSQFIITLGDKTDYLDGKAAIFGKVVEGFDVLEKINDAIVDDRGHPLVDIRIKHTVVLDDPYPDPAGLREPSSSPPPTKAQLATVRIAEDEELLDPEADENAAAEAERKRKEREAAAQALTLEMMGDLPFAEVKPPENVLFVCQLNPVTTDEDLELIFSRFGKILSCEVIRDKKTGDSLQYAFIEFEEQKSCEEAYSKMDNVLIDDRRIHVDFCQSVSRLSEAWRKETNDRRRAEAAHRTRGGWGGVEELEKRRQYRNEYTEPDHDKKYQMVHGMEDLRGRHARDSLTGLPEWLAEDLQGSGGRRLCLDACHRTKRRRQSREQRDVRASEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRG7</accession>
    <name>A0ABR3VRG7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="4">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="90932" checksum="0649977049139045" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V140</accession>
    <name>A0ABR3V140_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000661">
        <property type="protein sequence ID" value="KAL1835446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="370"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="413"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="545" mass="58899" checksum="08EAE98C7270B053" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V157</accession>
    <name>A0ABR3V157_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">VTJ49DRAFT_6673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000652">
        <property type="protein sequence ID" value="KAL1835461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="71" mass="7953" checksum="B1627AEDD929CF9C" modified="2025-10-08" version="1">MSFSIAKSSTPRDDLAVLRKQQPSIFPSDYTVSYSAFSKKRSGYSAFSKKCSGYSAFFKNSAFLEIYEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V174</accession>
    <name>A0ABR3V174_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000619">
        <property type="protein sequence ID" value="KAL1835528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF49">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="85"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="384" mass="42606" checksum="C43EBBA795ABACB9" modified="2025-10-08" version="1">MSTAGAGPVLAAATSTVAPPSLPLHTKPKADVPALPAGFPAHVSVKLAWTGSDFDNKSDHIFVLNELHHAEINAALESYKALGQDGDLIEPANFVLPTLGPKLRELSRDVHEGRGFCLIRGINPADYTVEDLTLVYLGVQSYIAEQRGRQDKRGNMLIHIVADNSTKQAAEHHRHSTKAITFHNEETGDVVGWLTRSTAATGGKCIIASAYTVYNVLAATRPDVIRTLARSDWPFAMPRFHCRPVIFYEDSRLIMNFGRAALLGNEAHPRPKNLPSLTARQIEALDAIEAVAKATQLEIQTQAGDMHFINNLAVLHRREGFANGQAPHEKRHLVRMRLRSAEHGWRIPRELEADWEEAFGATGVKHWHVEPMPLYFFPMRLYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1E6</accession>
    <name>A0ABR3V1E6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000592">
        <property type="protein sequence ID" value="KAL1835605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046656129" evidence="2">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="165" mass="16442" checksum="21DD8E95D4D34D1E" modified="2025-10-08" version="1">MRYYAAILAALAAAASAQDTTTIITPTLDTTDIIPTITDATTEITQVTETATPTTGSIASDLSSISSRLSSRLSSITAGASSVLSSLSSEWETATGDVRSSIESRISELTESATSAIHSATSEAGEHTSEVTQGATETPGAAPMVTAAVGLGAMLGGAAAVFVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2C2</accession>
    <name>A0ABR3V2C2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000541">
        <property type="protein sequence ID" value="KAL1835765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="611" mass="65397" checksum="D45A206DD63F2386" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V377</accession>
    <name>A0ABR3V377_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000512">
        <property type="protein sequence ID" value="KAL1835901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59673" checksum="6BB26150B4EA3C24" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3Q5</accession>
    <name>A0ABR3V3Q5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5178</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000415">
        <property type="protein sequence ID" value="KAL1836412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="167"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="663" mass="75494" checksum="00FA7B4BD39CB4E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3Z1</accession>
    <name>A0ABR3V3Z1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="4 11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5061</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4 11"/>
    <dbReference type="EMBL" id="JAZGSY010000402">
        <property type="protein sequence ID" value="KAL1836503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055265">
        <property type="entry name" value="Photo_RC_L/M_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00244">
        <property type="entry name" value="REACTION_CENTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="356"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="494"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1067"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1836503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1569" mass="173001" checksum="9413A4825A2548FF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V429</accession>
    <name>A0ABR3V429_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000400">
        <property type="protein sequence ID" value="KAL1836524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="462" mass="50028" checksum="0E84F778D114DC98" modified="2025-10-08" version="1">MAPEPMNGNGHNRRPDITVFSGGTAANSLVDVFNRIVEKRKCRLNYVIPISDNGGSSSELIRFIGGPSVGDVRSRLVRLIPNCENDGEMSALKALFEYRLDSDPIKARSEWLDIVESRSLLWGFISSPKRELIRSVLNTINLEIVKRARPPNVFNFASASVGNLFLAGARLFTGSFESAIYLLSMICSIPSSVSVLPAINSNFTHHISAGLRDGTTIAGQVAISHPSAPTALPDDTQVAPALTAADHDRIEDANLPGSLPALRRPNLAFSKHDEEDLPSRIERIWYINPYGHEIAPTANPQVIDALGRSDTVVYSVGSLYTSIIPSLVLRRVGQAVGGADGESTTTTPIRRRILILNSRVDRETGPRSDPMTATDYVRAIARACLESHAPRLVGRDDVLRRYVSHVVHLEGAGPEAGGPAVDAEELRRDGGRVVLRYDETALGEALEGIMDSSSSEGSCMDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4H9</accession>
    <name>A0ABR3V4H9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000401">
        <property type="protein sequence ID" value="KAL1836515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="266"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="420" mass="46138" checksum="B97AA9B8E3F45447" modified="2025-10-08" version="1">MFCFVFCGRGSTEEKRWLVERLRREVEEGLVVKVAENGAESEGKNKEVTLAVDAATIEARCPLLVSCYKETVRWVVHQLATRTVMSDTVLRDPRGNGREYLLKTGTLVQMAFGVGHGMEEYWGPRVDEVDLERFVSDGKKASSEGGGDAEGPGSARAMRTAFQPFGGGIHQCPGRRFAFVEIMAFIATMVLDYDIEPLEDGVPEFAALPMVAAVAKPANDGQGFGVRICRRKGWEGVRWSYKSHISPTNPTNQPYQPTPTMSESAAPTFILNLSTASPDQAVRFYTSLSFTHLPDWSYPGKTASFLLPAPNSHVGLMVHAKDQFKTFLPYGKAVANTRASAQALLSIMVKSKEEVDEWIEKVKATGVGRVDQVVFNGDYGVSMGMYTRSWEDGDGNAWEVFCMLAGAGGKEGEGEEEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4L4</accession>
    <name>A0ABR3V4L4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000374">
        <property type="protein sequence ID" value="KAL1836722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF2">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="711"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="887" mass="102458" checksum="7CCF6CE770AE1A4B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4N8</accession>
    <name>A0ABR3V4N8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000442">
        <property type="protein sequence ID" value="KAL1836238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="9">
        <location>
            <begin position="218"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="739" mass="84834" checksum="42B0DE2ABCAC5A5B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4X3</accession>
    <name>A0ABR3V4X3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000365">
        <property type="protein sequence ID" value="KAL1836795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACMSD"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="58"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="353" mass="39098" checksum="1C6F68D1B48FD3C9" modified="2025-10-08" version="1">MAPKIPKGTIAIEEAVIDPAGLSWIAESAPLFFPQASSTPDSAAPSAAKALNELLLDIHNERLTQMDAHGVEYMLLSLTSPGAQGEPDPSKARTLAAEANDWLAAQVAKNPARFGAFAAVSMHNAEDAVAEATRAVKELGMFGVMLNDYQAVAEGGDVEGKKYYDSPEFRPFWKAIEELGVPVYLHPRYPPARELAPGTKYGDRKHLLGAAVQFHLDLSMHLYALISSGVFDEFPGLQVVVGHLGEGIPFNLWRADHWYNKPSKKATRPSKHDYSYYFTRNISITTSGNFNTPALKFCIDQIGAERCLYSIDYPYDKIGEAQYWWLTVDLPEDQKRLVGRENAIRLFKLPLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5K8</accession>
    <name>A0ABR3V5K8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1857-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000358">
        <property type="protein sequence ID" value="KAL1836852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08863">
        <property type="entry name" value="SRPBCC_DUF1857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18580" checksum="EEA5A6B52DBDC323" modified="2025-10-08" version="1">MVTINLAYTAPINPPSTSPTLNLTWVWAGLVYKVRRPELFVPVITACEILNEEEAEEDVTITRRVTFRPDAAPPSGETVIEVCRLRAPCRVDFEQEDGTRIGNYVSEGPEGELYMTYVFEWRVPGVKVGSEEAKALEARYRKTARMAVEGSINTIRAIARGEISMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6K5</accession>
    <name>A0ABR3V6K5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000298">
        <property type="protein sequence ID" value="KAL1837399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047011754" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="147" mass="15295" checksum="9F2565C6D5B01B0E" modified="2025-10-08" version="1">MKLTLSVLFLGIGAARGAIAANFIGSCDANSVKVNGRTLQANCRNIFGQLTCSKLDLTKCLKNVSGTLQADPTGSGPHLDQCIKCTNTKPDGALAIGDPMPQLLYCQCNPGGGVAQANWPTAVFDLNTIVDNSNGVLECYKTKGTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6M5</accession>
    <name>A0ABR3V6M5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000316">
        <property type="protein sequence ID" value="KAL1837227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="184" mass="18851" checksum="B5E16F3B3F6A7C28" modified="2025-10-08" version="1">MESKRWGRKRTERPALGSLSHIPLEDILLGHAGLAEGIHGARAATAEGTNNNNPRLTAGLLGAGLQGLLDISDERGLVGVALDAGERLVSAVLELPGPGLEGERSAGETGVVAEGGNTATALVDQELEVEEGAAAAGEAGENLLPAVLLLVWRGTCQDWSSAQGQSVRGLTAMGELDVDVFKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Q9</accession>
    <name>A0ABR3V6Q9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000296">
        <property type="protein sequence ID" value="KAL1837425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="402" mass="45409" checksum="BEA05144776508B0" modified="2025-10-08" version="1">MDPYDELLHWAQDRGVELHGVAPRAIPGRGVGLIATKPLKASSNILLIANELIMHIPNSALRSIATVRPRIKKTLPEGTKVHALLAAELALDKPTSKHAPWNAVIPSREDVTSSLPLAWPDSRLHAYLPPKARTLLKQQSAKFERDWAVVTDSDSPALRHLTRDEYLYFWLLVNTRTFYHETPRTKQRLAHDDRMALQPVADLFNHADEPGCDVAFGAPGGGFEVTVGEGRNFQPGEELCICYGRHGNDFLLVEYGFVLQKNRWDEASLDDALLPELGPEERETLDDRGFLGGYVLDAETVCYRTQVALRLLCAMSVEEWGRLVDEGEDGGEKMQEKTDRLLLKILRKYRETVQRTIEELGSLDIGEQCQRDVLMTRWKQIQVLIDRATERLEAPSHMNIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Y2</accession>
    <name>A0ABR3V6Y2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">Sortilin VPS10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">Vacuolar carboxypeptidase Sorting receptor VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">VTJ49DRAFT_3728</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000288">
        <property type="protein sequence ID" value="KAL1837500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045207408" description="Vacuolar protein sorting/targeting protein 10" evidence="20">
        <location>
            <begin position="22"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1388"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1440"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="21">
        <location>
            <begin position="53"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="21">
        <location>
            <begin position="738"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1504"/>
            <end position="1526"/>
        </location>
    </feature>
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        <location>
            <begin position="1508"/>
            <end position="1526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAL1837500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1526" mass="171751" checksum="00695E2889193B54" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Z2</accession>
    <name>A0ABR3V6Z2_HUMIN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KAL1837532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="72" mass="7775" checksum="241E0CA741543D6E" modified="2025-10-08" version="1">MSRGEKRTKPHLFDDDWFTAPLPLAAETSQPIMLSSIAIVVCCAPNQGRKQAAAPGTMLPYRQLPPLAKGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
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        <name evidence="3" type="ORF">VTJ49DRAFT_4489</name>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000348">
        <property type="protein sequence ID" value="KAL1836928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
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        <property type="entry name" value="SurE-like_sf"/>
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        <property type="entry name" value="TTL"/>
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        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
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        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="600"/>
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        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="770" mass="84449" checksum="17FF06C417FB9596" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7D1</accession>
    <name>A0ABR3V7D1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
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                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000270">
        <property type="protein sequence ID" value="KAL1837704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="427" mass="45897" checksum="024A638FD3AA768C" modified="2025-10-08" version="1">MPRAVDQDVHSCFVEFRGTRCSSCNEKCLSVQCIYCQQVRAKNTTRQKQHLLQCPGYLASHPDVALQQASAAAATTTAQDASAQQPPPAGQAPVIPAPAAANDAGQAPQHPQHAAHPGAGPVGPVPGYSPHDAAAAAAAAAAAAADHTNLSFMPNPRINGSPISHPRPSLGAGEGTPAKKQKTKPSLGSNLPEIPLREVHAAFVEFRAKEDDKCLSARCKYCNQVRAKNTSRQREHLMTCPGYQAVLKDKIPANSLRHQFDDDDVASSLALPTPSVDLDFRMSIKVKPKLSIGTTISGKQSWISCTGGQWAGSWGKGVLLPSGEDIQTAVKDTATRIDATYLLQTSDEHPALIKCKMRGWLTGERDVMERLQDPVAADNVAAHRYRLRATMELETGDERYQDVNTGLWVASGCRRGGEIVYDAYRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V881</accession>
    <name>A0ABR3V881_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000246">
        <property type="protein sequence ID" value="KAL1837988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="523" mass="56422" checksum="969835F8F3BD60B7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8A0</accession>
    <name>A0ABR3V8A0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000242">
        <property type="protein sequence ID" value="KAL1838044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="749"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1059" mass="116168" checksum="971261FA87E0EC21" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8L2</accession>
    <name>A0ABR3V8L2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000263">
        <property type="protein sequence ID" value="KAL1837791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="492" mass="53846" checksum="791F99120FD2ACF9" modified="2025-10-08" version="1">MASAPKEKWLTKTFAASIFLGIGGFLYGYDSGIITPSLALSSFRTYFDNPDAPMRGAIVSLYQAGAWLGSASVGITSDRLGRRKAISFGCAWGVLGGALMAGAAHVSMLVIGRLLIGYAVGTITGVAPVYGAEIAKTRERARITAVTQMMVAWGFFVALWTGVGEGKWRNPNQWRLGFAIQAVPALLLGVGVLFMSESPRWLIIKGRDDEAEQAFRNWHFDGTNDAHCREEFATIRQSIRDEMKAQGNLGWGDLLRTPPFRRRLFVGVFVWAAAMLSGISFVQYFQTAIYATLRYDEDQQLLVSGLYGCVAPIACIISLLFVDKVGRRPIVISSSALLSVLYMVITILAAKYPARPGLPTNEDAQRAIIACIFMVSANYSALLGPMTWIIPPEVFTTELRAKANAVVQVVHYSISLIITQCSPIALERVGWKYYILFILTNALCAVVFAVAYPETKGKSLEEIDEIFGDIDRRDVENRSSGSGEKPAAERSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8X7</accession>
    <name>A0ABR3V8X7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000225">
        <property type="protein sequence ID" value="KAL1838275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="503" mass="56324" checksum="B1E887BB7BB0CBE8" modified="2025-10-08" version="1">MPGPDTRSEPPSEPSDWEVDDDDDDDDDDFDDDTEGSDVVASPAGLRYNLSRLSPRTRQVVKGLFNQRSPRDQPQISLELCAIREGEVDGDVFYAFQMHEVVPCSVRIGARDSARFSTPRCECPDARYRRLRPCKHLIWLFDKISKHALFDHDPDAELTLTELGYPEELGDPFGRISQIRLDVLADDLHCDTSEPDSDNVYPSPARVREAREMVAAVAGIQPHEVDDYRRDLEASHDKGPLIHRGDLGATLFSLLLASHSLAEWVRSELSPSDPAVDPFRSAQHRVFRIIEELKAYSASEQDPSTSDSYRRRGKHAEGPRDLTWAAGQIQHCVRRIDKLVSRGSSPLSEWARSSAARALVIILKMVTDHRDLYQRLVGDHDTGFVFSTLDILADQSQYVDALDDIMDKIGVYGAPPSYVANMRSLIARMRSHKPADDAAAAIVATGSDPKRAGYRSKRAGRRCDPREPGEGRPWQGIETARPSRQPSWLEEEASRRLTSTDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V982</accession>
    <name>A0ABR3V982_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000232">
        <property type="protein sequence ID" value="KAL1838180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="50"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="376" mass="43098" checksum="FD33A5C8C3E6C3C7" modified="2025-10-08" version="1">MASLPTAVRATAPKIAKTALRRGIHSDVHITRTGKPLIRVTGGRSSLGEHTATVFGATGQLGRYIVNRLARQGCTVVVPYREEMAKRHLKLTGDLGRVVFIEYDLRNTQSIEESVRHSDVVYNLVGRNYPTKNFSLADVHIEGAERIAEAVAKYDVDRFIHVSSYNANPESSSEFFATKGYAERVVRDIFPETTIVRPAPMFGFEDNLLLRLASVTNLFTANNMQERYWPVHVVDVGEALEKMLFDDNTASQTYELYGPKNYSTAEIAEMVDREIYKRRRHINLPKALLKPVAGLLNRVIWWDYMSADMVEREFHDQVIDKSAKTFKDLGIEPSDISQWTYHYLKHYRSSTYYDLPPATEREMREEKKYLHVLDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9B5</accession>
    <name>A0ABR3V9B5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000218">
        <property type="protein sequence ID" value="KAL1838377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36530" checksum="39921408D0596383" modified="2025-10-08" version="1">MTTHQDYGLKTPGSEVARAFAERIRGKTILVTGVSPKSIGSATVLNLASQGPGLLILASRTEARLREVAAQIAEKYPDTRVEIVILDLGSQQSVRQAAVDVAALTDKLDILINNAGVMVTSRKATPEGIEQQFGTNHIGPFLFTNLLLPLLRKAAESNPPGATRIVSLSSAGHRLSPIRFSDYNLEGKPVPPEEDHVKPLQGAFAKCAPDGYNGIVAYAQSKTANILFTVYLQKHLTKFGIAAYTLHPGTIQTDLSRDQNDELTAQFYKVAPYWKTPDEGSATTLVAALDPALDDAKGLYLVDCQLAEPAPHTRDSISADRLWKLSEDLVGEKFSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA59</accession>
    <name>A0ABR3VA59_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_2617</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="13"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="198"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1838510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="394" mass="41768" checksum="3529500610CC3C8F" modified="2025-10-08" version="1">MADTKVYRASTTAPVNIAVVKYWGKRDAKLNLPTNSSLSVTLAQSDLRTLTTASCSASYTEGDSLLLNGEPSDVSGARTQACFRELRARRAALEAADPSLPKLSTMPLRIVSENNFPTAAGLASSAAGFAAFVRAIANLYELPASPSELSLIARQGSGSACRSLFGGYVAWRMGENPDGSDSVADQVAEASHWPEMRALILVASAAKKGVSSTSGMQQTVATSGLFAERVSCVVPQHMEGMERAIRDRDFAAFAEITMRDSNSFHATCADTYPPIFYMNDVSRAAVRAVEQINAAAGRTVAAYTFDAGPNAVIYYLEKDTELVVGTFYHALGGEVPGWKQTVVSGLKPSLSLDEGVAALLKSGISRVIQTGVGEGPIRTDEHLIGEDGTPVKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAX0</accession>
    <name>A0ABR3VAX0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000181">
        <property type="protein sequence ID" value="KAL1838989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="347"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="754" mass="82205" checksum="AD78676EC9429B6F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAY0</accession>
    <name>A0ABR3VAY0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000197">
        <property type="protein sequence ID" value="KAL1838712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="64518" checksum="9E0749AA060BE523" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB61</accession>
    <name>A0ABR3VB61_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000193">
        <property type="protein sequence ID" value="KAL1838787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="200" mass="22027" checksum="40F79731972615A9" modified="2025-10-08" version="1">MAFLILVIGDLHIPDRALDIPPKFKKLLSPGKIAQTLCLGNLTDRATYDYLRSISPDLRLVRGRMDVEAASLPLTQVVTHGAVRIGFLEGFTLVSDEPDVLLAEANRLDVDVLCWSGGSHRFECFEYMDKFFVNPGSATGAMTPDWNGEEEVVPSFCLMDVQGISLTLYVYQLRKGENGTENVAVEKVTYTKPVEPTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBI2</accession>
    <name>A0ABR3VBI2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_1787</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000170">
        <property type="protein sequence ID" value="KAL1839198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051600">
        <property type="entry name" value="Beta-PGM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193">
        <property type="entry name" value="6-PHOSPHOGLUCONATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193:SF18">
        <property type="entry name" value="HEXITOL PHOSPHATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047522762" description="RING-type E3 ubiquitin transferase" evidence="16">
        <location>
            <begin position="31"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="SWEET-like" evidence="17">
        <location>
            <begin position="591"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="504"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF11145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1839198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1121" mass="123610" checksum="BBE1964723B711AE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBL6</accession>
    <name>A0ABR3VBL6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">VTJ49DRAFT_1890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000176">
        <property type="protein sequence ID" value="KAL1839089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="348"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="426"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="541" mass="59318" checksum="F9C9644B376117FF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC50</accession>
    <name>A0ABR3VC50_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000166">
        <property type="protein sequence ID" value="KAL1839287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="285" mass="30543" checksum="D3915B5622E5425B" modified="2025-10-08" version="1">MAPASSIPPPLPPSVEEAYRRKCIQLKQRTSEVEEANDAARLRLARLKRQVEKMRLERAFLLEQLAKRTSTNVEDSDGSPSPPPTPKEKPLRVKRGHRKAPVLPNLDAPAGSTAGAGTPGSTTFISQNLLVHSPSSDALSAQQGDAKANGVKDGQPKKPPTAFDLYCEEARKDKADLDEETVLSAWKDLPDAKRAEYQTRADELLAEYEKDKAAAAADAAATSKTEDAAGKNGSAATAGHDKGDTTESERPAGEDEAKGAAAPDEDVEMGNYDTDQETQVDKPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCI3</accession>
    <name>A0ABR3VCI3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="193" mass="20948" checksum="12A69219B29E6AE4" modified="2025-10-08" version="1">MDASAITSSPTQRAKIKDESAAYLRSLLNKNLRVTTTDNRMFWGSFKCTDYESNIVLQHTYEYRFPMVTPESLAAAAEQQSQQSQQEEQKPPETATETETESQPNPSSTTATPPNQKKTVKLDMTSRYLGLVVVPGKHIVRIEVEEFASQMRGRQQQQRRVLAKPPASADGVGEEGGGGGGGGGCDVGVGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCJ4</accession>
    <name>A0ABR3VCJ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000159">
        <property type="protein sequence ID" value="KAL1839398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="64165" checksum="57F6654C3AEE046A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD16</accession>
    <name>A0ABR3VD16_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000149">
        <property type="protein sequence ID" value="KAL1839599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="524" mass="56424" checksum="66E9D2065EA691EB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDZ7</accession>
    <name>A0ABR3VDZ7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000162">
        <property type="protein sequence ID" value="KAL1839356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="250" mass="28343" checksum="509C3F93E7431B9A" modified="2025-10-08" version="1">MARNKGHRRGDNNRQNNNNHHHHNNNNNGRINFNDGNNNTNNTNNSRNNNVNNNNNGSRNNNGNNNGNNHRDGNTYNGSNNNNSNRNGNNNRNSNGNGNGNRNNHNNYNNRNNHPRILPWSDIVHQLISTRPGQRPDPRLLQMLISSASVMLELTWDVYERRGLTDAQIARELALPWQACARLAHFCDRANVGLMEAVVDAEGDVMMVDVDDERARAATARDEAHLPAVHLVDLLMRDLRASLEGYEWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE43</accession>
    <name>A0ABR3VE43_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000127">
        <property type="protein sequence ID" value="KAL1840095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056485">
        <property type="entry name" value="ARM_KRIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24521">
        <property type="entry name" value="Ank_KRIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="KRIT1 ARM-repeats" evidence="4">
        <location>
            <begin position="535"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7593" evidence="3">
        <location>
            <begin position="1211"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1433"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="853"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="905"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="964"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1489"/>
            <end position="1509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1542" mass="173623" checksum="C2DF327E50293661" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEN2</accession>
    <name>A0ABR3VEN2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="203" mass="23141" checksum="D844D2DE9C413931" modified="2025-10-08" version="1">MTSNKRITKELAECTTNPPVGITVTLPNDSDLHTWHVILDGPEDTAYAGGKFGLVVKLPTEYPFKAPTITFATRIYHPNVTNDSLGNICLGLLKSDKWKPSTRLSSVLESVRALLEEPQPEDPLEARIADEYRNDRSEFDKNAKAYVQSEMKVREIQMKWNGLEQYAGLQDQEEKRWFWIMVWAIGKAKVRPKEVMASDDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VET6</accession>
    <name>A0ABR3VET6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000116">
        <property type="protein sequence ID" value="KAL1840369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="403" mass="42667" checksum="CA542CFDA28F7B35" modified="2025-10-08" version="1">MSAPQTPAHSPQPSLDYSAASFGSFSPHQDRRQSKASSFNDSSTDLGISAGAGNGGGGGGGLGNLADELAGAFYDGEDDDYDGYDDGAYEDGVEDEQDLPGQGPGINLEHVSGQDGGQGPAGGEGLRDSRLESNTPTDAARSNLNLPVPSNGRGCHHHHRRKGSEYDGSDYGSESDLDSPGMPPRLVDKMDEIEALARRGTENIGSAADGAFKRVTEGLRDLSSQAGVESAATRLITAHTALTTHLTHQTRQLHNLTFPLLSPLAAPPSEESVAALLPMLLTLTELLPRPSTSSLTALDSLHTLSADLALALNHLSDALHMARQTTQAAGRRLRGARELVAEMRRDEELRVEAEAWINRGGWGERLRKRECAGVCGDVVGGFEKVCESWRERLVALAEGESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF72</accession>
    <name>A0ABR3VF72_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="350" mass="38848" checksum="03E8D66A8EC6C972" modified="2025-10-08" version="1">MPATTAETLSLVTRNVSVAPLVLLSVVDHYNRTESYKSKTKRVVGVLLGQNDGKNVRVSNSFAVPFEEDDKDPSVWFLDHNYVESMNDMFKKVNAREKLIGWYHSGPKLRASDLEINELFKRYTPNPLLVIIDVQPKEAGVPTDAYFAVEEIKDDGTTTSKTFVHTPSIIEAEEAEEIGVEHLLRDIRDVAVGTLSTRLTNQLQSLQGLHLRLRDIQNYLQKVLDGQLPVNHAILGNLQDVFNLLPNLSTPKHGSGPGKGDTELSYAMSVKTNDQLMAIYLSSLIRAITAFHDLIENKIQNRQQAEEKEAAKKEEAGKEGEKKEGSPAANGEAKEGGGDKEKESAKDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFU0</accession>
    <name>A0ABR3VFU0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_359</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01489">
        <property type="entry name" value="Uba2_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="44"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="11">
        <location>
            <begin position="338"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="12">
        <location>
            <begin position="476"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="72173" checksum="3BE82BF3A0368F28" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFU6</accession>
    <name>A0ABR3VFU6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_184</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="230"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1840744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="332" mass="35708" checksum="2496ECF3C0F77649" modified="2025-10-08" version="1">MDPNAAMSDGSKTALSKSTFHFVAGLGSGVFTAVLLQPFDLLKTRVQQSGTHSLSAAIADIWAAPRILPALWRGTVPSALRTGFGSAIYFTSLNAIRQTAARLSSPASRSANPQSSSSSLPKLSNTSNLVAGAVARSLAGFILMPLTVLKVRYESTLYSYTSLASAAKDILAKEGVRGFFSGYGATALRDAPYAGLYVLFYEQSKKRLSTLFPASHPLQTSIPTAMPTPHAATINFTSGILAGALCSAVSNPFDAVKTRLQLQPARYRNMWLGAGRLVREEGFRALWDGLALRMARKALSSALAWTVYEELVRRAEVEWGRRTGRGDARDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFV3</accession>
    <name>A0ABR3VFV3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000108">
        <property type="protein sequence ID" value="KAL1840553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF963">
        <property type="entry name" value="AT08303P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="948" mass="107068" checksum="1B91CA6720F4527A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFV7</accession>
    <name>A0ABR3VFV7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000118">
        <property type="protein sequence ID" value="KAL1840311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="88" mass="9474" checksum="4ECECECC9D643C2A" modified="2025-10-08" version="1">MALRKTITISCPSLSMTQDYLPKQANLSVDTIISKAPSSIWRIFRLTAGARHSPAVAKRKRSQSQAPGSASPAYTHLMCSDISAGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFZ5</accession>
    <name>A0ABR3VFZ5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF5">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PROTEIN (LEA) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="268" mass="26963" checksum="2D611BB955D7C51E" modified="2025-10-08" version="1">MSALTSSTRLIMGRGTMRLAATTRTALFTTSLQRRNPGVIETAKDKLKSVDRKVSEKLVDGINVGAAYANKLKEATADIKSGRVTGKASELRDEMAGKASSAAGQAKGKAHEVAGKAKGAAHEAAGEMKGTASQAEGKADQMAGKASEMTGEAKNKAGEAAGQAQSKAGEVAGEVKEGAGQAWGKAEEMAGQAQGKAGELAGKAGEMAGQAQSKAGEMAGQAQSKVGEMAGEVKEKAGEAQGKASEVAGKAKGKVQEMAGEAKEKVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG54</accession>
    <name>A0ABR3VG54_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="154" mass="17349" checksum="39F46CA1C5BBC7C0" modified="2025-10-08" version="1">MSPTSNLYRAARPAFRARAFFFRPKPQTGARFQSTTASGPQSESWVKRMWDSPVGLKTVHFWAPCMKWALVLAGISDFARPAEKLSVTQNGALTLTGLIWTRWCLIIKPKNYFLAAVNFFLGMVGIVQVTRIGLYHQKQKRLAAEGKTEEIVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGG1</accession>
    <name>A0ABR3VGG1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endosomal peripheral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000093">
        <property type="protein sequence ID" value="KAL1840944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="8">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="6">
        <location>
            <begin position="200"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="7">
        <location>
            <begin position="977"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="746"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1564"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1574"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1716" mass="186796" checksum="6F7A9FC515083FB2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGL3</accession>
    <name>A0ABR3VGL3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase regulatory factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000097">
        <property type="protein sequence ID" value="KAL1840832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
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            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
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            <begin position="133"/>
            <end position="156"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="97132" checksum="D22F15C544F4EA53" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH45</accession>
    <name>A0ABR3VH45_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000114">
        <property type="protein sequence ID" value="KAL1840421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="405"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="535"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="753"/>
            <end position="762"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="891" mass="94829" checksum="C4D5693F96B2B8F8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_7292</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soft-rot fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1841224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
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        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="561" mass="61310" checksum="96C4877BB06D8ECD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH81</accession>
    <name>A0ABR3VH81_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000085">
        <property type="protein sequence ID" value="KAL1841144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1930"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1948"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1974"/>
            <end position="1986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2012" mass="220030" checksum="3EEFEF981906C1F6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH87</accession>
    <name>A0ABR3VH87_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phospholipase A-2-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="376"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="494"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="86415" checksum="14C2FBB265D1141E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHB3</accession>
    <name>A0ABR3VHB3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="48"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="331"/>
        </location>
    </feature>
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            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="331" mass="35291" checksum="43EBA84AF7D9B306" modified="2025-10-08" version="1">MHLRGSHTLAPQSGNDDMSPLQFSTCSLLGNEHASLFATSPHFDTMATTIRVKNIGAQTSDSEIKDFFSFCGKITSIDITKEESNKSATVVFEKDTAARTALLLNHTNLGGNEITVEGEGNLSTTPPPEQEPTTGGATTAERTGSPVLSQEEKPPSRILAEVLAHGYLVAEQGLQKALAIDEQHGLSARFVTTLRKLDERTQATERAKSADESYGLTRKAGSLLTGLGSYFEKAKDTPTGKRIVAFYTARQRQVQDIHNEARRLAELKKEETGGDLVKGLGLDKVGLDKVLGRFGGGQAQGQEGKKEGESATAPAEAAPATEAKEKPAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHH0</accession>
    <name>A0ABR3VHH0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="478" mass="51537" checksum="8A544E01B90F111B" modified="2025-10-08" version="1">MAPPIPVLPNLIDIPNPPPYRYSNNDSDNNNHHPHSTCTHCPAYYHDDSDDEAVNHPPDLPPITRPALNAYQYHTFPPVCGSGSEGDAAPAAMMGVTRNSNPAEPLPPYDNPLSFYAADEKSTSPGAGSNHHEREGLLPSPPTNNSTGSNERRLCSCPTHHAPPRQSGSSTSLFRGRYNLFAPAPFDLGTMAELDAERAAGTTHHCPAHRHQLRWRQLRRRRRVVCGTVFVVTFLVLAAVVVSTGGWAGKGCGMVGWVKGVGGWGLPVSGVEAAGVPRVASPGYGVVDDAGPDGVDVQFVAAHSVGTLHPGPLNPVDTGIEDGVGSYQVGDGDGQLAAGGDWEAFRGDGQWSDGDGEFFGDKDEIDDWSGEIGEGDDRFSYDHGDFISDGEFFADEDGVGEGGELSDEDVQFLEWLKEVFAGDDELAERDGEFFHRIDELVEDDWLPGDDQAFRREDGHSIEDGEVETDPALDDWEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHP4</accession>
    <name>A0ABR3VHP4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000077">
        <property type="protein sequence ID" value="KAL1841379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="314" mass="33779" checksum="111647BFF19E4174" modified="2025-10-08" version="1">MMEYAQYQQPQSAHSQPHIQTGYPNSAGSNNITSPSTQHLSQTSPILPSQQHQTSPSQPHNMYQAQYAVPQSGMHYGMPGIQAAAMAATAAASGTSYYMSSEPSLQQSPRMSGVAKKDVRAGPRSPQQMNNIQQQQRRMSQVASPGVPNAPSLMNQRPGVPPPMTAAQQMPPPQSPEIASAPVEESPLYVNAKQFHRILKRRVARQRLEEALRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTAQEVAELEREKAAAAAAAGGEKAEGGSDQAATNNNSKTATGATKRKSDGTAPSSSPNKKAKSSPSEDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHV9</accession>
    <name>A0ABR3VHV9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000080">
        <property type="protein sequence ID" value="KAL1841297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
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        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="9">
        <location>
            <begin position="248"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="403"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="550"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="703"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="1126"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="903"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1393"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1097"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1410"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1432"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1454"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1465"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1490"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1500"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1552"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1634"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1653"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1668"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1710"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1737"/>
            <end position="1749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1749" mass="191048" checksum="F09CB95DA98C89AC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHW7</accession>
    <name>A0ABR3VHW7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mechanosensitive ion channel protein Msy1/2-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000093">
        <property type="protein sequence ID" value="KAL1840933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel protein Msy1/2-like transmembrane" evidence="3">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="789" mass="88291" checksum="ADBF4661A26CE3F9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VID5</accession>
    <name>A0ABR3VID5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="151" mass="15817" checksum="8A4CB7D53E5D73A0" modified="2025-10-08" version="1">MEFGLLLVIGALIILITSLSLALVLSAVGLLGILHLIIGVLLGSFHQLLDGSITARLLGFGGVAGAAVDLFIIVRGLVIGATKKLLEILIVFFVLIADIGLIDLEGRAGNRRDVALAIGLGFRRGINGSHGNPDLEDTVRKSMAEKVSRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIF5</accession>
    <name>A0ABR3VIF5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="8">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2151" mass="243766" checksum="2BEB5219628F66B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIG8</accession>
    <name>A0ABR3VIG8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_6770</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="421"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1841664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="627" mass="69818" checksum="B85AA82827BE0EF7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIM9</accession>
    <name>A0ABR3VIM9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="394"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="751"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="815"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="422"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1166" mass="130476" checksum="620314259D784CC7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIQ0</accession>
    <name>A0ABR3VIQ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="75"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="3">
        <location>
            <begin position="225"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30754" checksum="16670F333813C25A" modified="2025-10-08" version="1">MPKDNFVPDAWDDDDWEAKADLAAKQRSKAPAQPQPEPPMTRAERLAKHAEEQRKLWESADSLDEAPFLPPSTNPIPFSTAFKPPVKVLSRKPTPQVIAKRDPTTGLEQLTLEDEKEEDGANQAKKQETAEDIRKRLEEKQRRYEEARAKIFGDSNPSSGQSTPRTGTPPTGGSEGRQSHRGRGRGRGRGGRDQDNGRQERRSQGNQQQQQPGGTRELFDPNYSPKPGFHLQKRGDRAAQPGGRGNAPREEDQVIRAPRGPDGTGRGFGFARRGGAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIR3</accession>
    <name>A0ABR3VIR3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="8">
        <location>
            <begin position="143"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="437" mass="48973" checksum="D6D2D3651AACA27E" modified="2025-10-08" version="1">MAPKSRFTRLDAFAKTVEDARIRTTSGGIVTIVSLIVVLFLCWGEWSDYRRIVVHPELVVDKGRGERMEIHLNITFPRIPCELLTLDVMDVSGEQQHGIQHGITKTRLRPVSEGGGEIESRSIDLHSRDESARHLDPDYCGPCYGAPPPTKPMKAGCCNTCQEVADAYAQAGWAFGRGEGIEQCVREHYGERLDQQRREGCRVHGGLRVNKVMGNFHFAPGRSFSNGNMHVHELREYWNTTSPHTFTHIIHHLRFGPQLPESLYKKLGKKADLPWTNHHANPLDDTRQETDDTNFNYMYFIKIVPTSYLPLGWEKTWAGFREQHHAELGSFGASADGSVETHQYSVTSHKRSLAGGDDSKEGHAERQHARGGIPGVFFSYDISPMKVINREERSKTFLGFVAGLCAIVGGTLTVAAAIDHALFEGTVRLKKMRGKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIU4</accession>
    <name>A0ABR3VIU4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="431" mass="46969" checksum="99C9B59E65001EC6" modified="2025-10-08" version="1">MHDSLYRHFGTQNLWEEYTVAKSPIVEVTEIWVPDDCLSLPAVTESKTISTPDVDNWLDEPPARTFATGTYTRSARLVWVGEDRNRRRASPSAIVLNHLATAWGLEDALAYARGCFAGVSTLEVGERRVFTVAYHPKLAVAWSHSTACGTCAIVFAEGEERTDLLRILSSEWRGSTVAHPMFPGLLCSLVLAHSLDKTLAEIKAAVREVEARTGHHRFASRHETRPAAGELGSLSAHMSGCAAKLANGTRKMKVVEAVNDFLAQHASGTASSCVQDDPFSPASLALLRHRVAMQEVDTTYVQQRVQIQIAALFHLIAQQDNAIAFATASATRSIAASSLQDSSSMKMLALVAMFFLPGSFVAALFSTPLFAWEDAYASDGMGVATRPQFALFWAVTAPLTVLVFLAYSLWMCVQGRRERAESHNAIPLGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIY4</accession>
    <name>A0ABR3VIY4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000066">
        <property type="protein sequence ID" value="KAL1841716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="319" mass="35453" checksum="7BD73D4547734119" modified="2025-10-08" version="1">MAGKGVKCLSEALRGLSLGAQPCRTTPARQAAMGCIRSMATAVEGKPSNITRSVDEVYTPLTTVPVTIHSFPTLEPRSLEAWSTKHLYLPLRRDILHLAVVYEGDKTRQGTASSKTRWEVAGSHRKMRPQKGLGHARLGTRQSPLMRHGGKTFGPKPRDFSTKLNRKVYDLAWRTALSYRYRRGELIVTEDGLDLPLPDEFLYAASKGVLGREVEDGFVSKYLAELLAGLQWGREYGRTTFITGDRRPNLFTGMEVGGENGRALELDEVDVKDLLETGRIVIERSALREMIKTHSSDLVQRVQVPGLRTKPQLGTAIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ13</accession>
    <name>A0ABR3VJ13_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045125254" description="CBM1 domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="7">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="436" mass="47862" checksum="37590614B908FA95" modified="2025-10-08" version="1">MKVQQRNLLAAALALAGTPGAEAVLRFSCSELVTERLDPLVFPGVAQSPHLHQIVGGNMFNITMDPTQHNIGEEATCTTCTFSEDFSNYWTATLFFRARNGSFIRVPQRGNIDFESARGGGMTVYYAPGYQNQRVTAFQPGFRMIVGNPFYRTQAEASKFRQLTFTCLDTLYTRTGETTSMPTRPCREGIMANVRFPTCWDGVNLDSPDHASHVAYPSSGTFESGGPCPASHPVRIPQLFYEVIWDTRQFNDRSLWPEDGSQPFVWSYGDYTGYGTHGDYVFGWKGDSLQRAMDANCDVFCPQLRTQSIAQANQCRQQQKVRENIDGWLDSLPGNMEITGPQPAVGGGGNGGGNPTPTQPSQPGTPTNGGGNSGCTVARWGQCGGRGYTGCTRCAAGSTCRAQNEWYSQCLRDPGQLKQDTLWLCLSQHDHVMTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJC5</accession>
    <name>A0ABR3VJC5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="133"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="306" mass="33372" checksum="29B128E6353601CE" modified="2025-10-08" version="1">MPPRLNLWSACRALSIRTRPAVAASRPQSAALAAPVSLARRSFSDNASTQLPPNNSNLPPPPPPSSSSSAAPPPSTPNPGESSAVEVPTSPENEMALNQLRMIEYGLSPLDPAVEGHKYGLPELPLPSQKNSKYRYDGVVEQLTKLIMKDGKLAKAQRDMAMVLNYLRTSPPPRLDPSKPLLPGAPPAHHLPLDPVLYLSLAVDSVAPLVKLRPFKGLAGGGKSLEVPIPLRARQRRRIAFNWILDVVERKKSRGSGRTQFAHRLAEEIVAVVEGKSTVWDRRLEQHKRGTANRANLLHHQVKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJG3</accession>
    <name>A0ABR3VJG3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000059">
        <property type="protein sequence ID" value="KAL1841925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056416">
        <property type="entry name" value="DH_2_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056222">
        <property type="entry name" value="PH_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056223">
        <property type="entry name" value="PH_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24340">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24344">
        <property type="entry name" value="PH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24345">
        <property type="entry name" value="PH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="2024"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="925"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1345"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1608"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1783"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2058"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2225"/>
            <end position="2326"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="296"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="432"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="490"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="505"/>
            <end position="514"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="764"/>
            <end position="774"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="822"/>
            <end position="835"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="841"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="971"/>
            <end position="981"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1367"/>
            <end position="1380"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1484"/>
            <end position="1495"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1496"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1541"/>
            <end position="1554"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1805"/>
            <end position="1827"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2063"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2073"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2092"/>
            <end position="2111"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2121"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2187"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2275"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="2308"/>
            <end position="2319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2340" mass="253692" checksum="C54CC48030143CAF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJY1</accession>
    <name>A0ABR3VJY1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000051">
        <property type="protein sequence ID" value="KAL1842199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="95"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="332"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="483"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="504"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="545" mass="58674" checksum="A1A0A082FFA09EDB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK72</accession>
    <name>A0ABR3VK72_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CwfJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="303"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="454"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60458" checksum="542DED832AD0F563" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKH2</accession>
    <name>A0ABR3VKH2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="495" mass="53763" checksum="D1C06AA530518AAA" modified="2025-10-08" version="1">MRERITYIQKLGDGLDPSTVRVDAGAIRAPDVHAIREDRLTFTLDELPGELRTLLADTQDLHIRWVSTHAYEAVSPLLARLPPGFHAFFTPGDGNDSVASYAAPTSPSVTGIQTNPESFISLPRDRFSHSAAHQYFQQLDSLGSFIQYAKDKLCSRADKACSARLDGLSRAASLDISYESREGVLRVTALWPYQSRPIDATSRPGVRTEVGILSGDKPKTLEPHELGVAGLLTVLGQDSKPSAAMFSFPARHHDAESTFSALFLSPTGLHPTLQLRISSAALPAEAEHDGQDCSPYAYLTLPRSIFADKYQLSDPLFLASKNLSALRHTTQPVDLEAPEYAVSQWGSAILLELAPSSPSSSEEWTAEVPLHLRYLAPVSGGYSTVSVPYPAVFWACQPPEGAEFPPGPFERKALGYDGLFDDGTVFWHVTPQPAEADGQGLLVSQVRVPVLNVDRAQWVGAGTGLAVAAGFAFVVWKLAGVWFGKGQEVDEKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKI9</accession>
    <name>A0ABR3VKI9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="686"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="719"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="822"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="93394" checksum="DE19E137B31569CE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL72</accession>
    <name>A0ABR3VL72_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="65" mass="7365" checksum="34D530167B00802A" modified="2025-10-08" version="1">MCRYYAHQHKCTHTTLSFAAFCDPASMIQNPCAERQIWQTLDVDEPCDDCRAAAAAASSTGRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLL8</accession>
    <name>A0ABR3VLL8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Auxin efflux carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000033">
        <property type="protein sequence ID" value="KAL1842783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="65682" checksum="6589E6D7E47F752D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLZ3</accession>
    <name>A0ABR3VLZ3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1265"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1289"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1322"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1370"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1409"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1419"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1438"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1483"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1533"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1550"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1561"/>
            <end position="1606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1627" mass="178423" checksum="5E7A69663F77A206" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM49</accession>
    <name>A0ABR3VM49_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="91" mass="10162" checksum="2874B31758F6A465" modified="2025-10-08" version="1">MTNRNPIRLPPLKVLRVRNPNRHEPNPCLNIMSSVLACWASAGYTGRGCTTVENALRACMDAPPPPPKAPNTINYHLNRFSKRLISQGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMG3</accession>
    <name>A0ABR3VMG3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="331"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="371"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="492"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="532"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="725"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="856"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="725"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="862"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="894"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1056" mass="114587" checksum="4E3D92EDC2551069" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMQ0</accession>
    <name>A0ABR3VMQ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="769"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="832" mass="92166" checksum="2AE2669FCA99BF00" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN64</accession>
    <name>A0ABR3VN64_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="146" mass="16760" checksum="4FB5408DB40ECBD8" modified="2025-10-08" version="1">MHTGFVSLVTASQLINFAVICVTYLRSHGALRVQGVDRRTLPYRATIQPYAAWYALIACSAMAFIGGYAVFLPGRWDVPTFLFSYTMIGVCPILYVAWKLLKRTCVYRSDEVDLQKNMDEIAEYEKNYVPTPPKNLFERMLDRLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNA2</accession>
    <name>A0ABR3VNA2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1956</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045713499" description="Translation initiation factor eIF2B subunit alpha" evidence="11">
        <location>
            <begin position="23"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="393" mass="42847" checksum="070F753F9C3B101F" modified="2025-10-08" version="1">MFRRGLLPSFASASFFTSIVMAADGPSSSASRAESSTQQQLPVRSASSNSTATNEVTTQVDNGSSFDIVRTYRELLNSDRELTMGVAAIESLIELLRVTPSSTAMELVEIVKKEKAKLLASTPNPLPLLAGADLFEQYLLRSLRGPTAAPGSGSGQDRVLSFDETRQHLVDNKDLFAQRAKAARDHIALWGSRYVSDGCVVLAMGGSRTVTKILLRAAADPSKHFRVIYVVDGRNPRSDVAVAQLREAGLEVETISPLKVAYVLGNQKRINLVLVGTEVVMQNGGIISGMGTAQLAHLAKTVKGGMRRFYVAAETHKICRRTPIAYPMVNRVGVRQKDISKFDNIGVDPDPDTIVLPEDEEVDYTDPELIDGFITEQGVKMTSQIWEMVDDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNH4</accession>
    <name>A0ABR3VNH4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF447">
        <property type="entry name" value="FK506-BINDING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="113" mass="12437" checksum="670F09A736E28F17" modified="2025-10-08" version="1">MGVTRLTHVQGTGPQPVRGQKVTIAYTGWLKDTSKPDNKGQEFDSSIGRGDFVTEIGIGRLIRGWDEAVLEMRVGEQATLDITSDYAYGERGFHGHIPPNADLIFDVHLKAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNS0</accession>
    <name>A0ABR3VNS0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="371" mass="38797" checksum="82E6C4D134C6BF6D" modified="2025-10-08" version="1">MQLASTLQPSSASSTEVTPADAQDGSTMTVAGPLTTTFGAPSSCSSDAAQIYQVWSGSASSYVAGPFYTRDSDCFPSGYDPEPTKYFSPGWCPQGYTTACSSLATAGRETETAVICCPAHYTFSCPAAGRTDGPSLGCTSTWTDALAVLAVTVVRDGETHTTPTLVSETAGGITAYGIQVRFQSTDPTPTPTTQVDDDATSSLPSVSIPTDYFIPTPTVSPSSSSGVSTPVAIGIGVGSAVAALLLAGAIGLFFFLRWRRKKQSHPESASQSRSDSPPPVPPKELSASPVPYRTVPPPYELSEDTSPRRAGSPSSMSKRHMSTSPVPGWTSASTRGRRYSARKDSQLTAAVAVFEGAQVRVAWVGEYQRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNV3</accession>
    <name>A0ABR3VNV3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="479" mass="54498" checksum="06B7A0F45CB2F4FF" modified="2025-10-08" version="1">MDRNLIPHGPWKVQALVPQVTLEDVKRETAPMSRHPNSENPIKDGGPGGSGAPGHKGTPSDDGAAGRTDRPGRGGSRGRQGASGSNGGPGAPGGGGRPGRDVNDNQQSESELDRCAICLEPLSSSSPCEMRPCHHSQFHYSCLKTWLERNPVCPLCKTNVEEVRHTNPQGDATFFLPAPRSDRGERGGPPALPPSVTRGLGIVPGWAIYWSQRQRVIARQPSRRPEAGDAFDPRNPANRVWRQESEVWRPSQPEVRAVLRRRHIYRCHLFSLHVGSNPISGYRELPSPAEFSSNPALITRARLWIQRELRVFSFFCDLNLDDRTAGDITAMPHRLLLPRAGEQQMELRYRRAHDAWNFLEYVIEMLKTIHLQDPAGRAEARLVDYLGPDHTRLFLHELRSWLRSPARSLEEWDQEVQYPAEPHLLHFPEVDLNRRQGDTRSPIQSPGGRLRRERERVERDRREWQRRERERRERREADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNV6</accession>
    <name>A0ABR3VNV6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 6B-like protein new16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13445" checksum="5CF56B2548259AE0" modified="2025-10-08" version="1">MGLLSSLGLTSPSPEEKRASEVRSGAVAPTRAERQRCWDARDAFFACLDAHGIVDAIKEDKKAASACKGENARFESDCAAQWVTYFKKWRVQDIQKKAKLKELEAQGANKMEVHTDFTPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNY3</accession>
    <name>A0ABR3VNY3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="166" mass="18512" checksum="6C0BDC34E73D6506" modified="2025-10-08" version="1">MSEELTKVDSAVQGIETKETTKESKRRASASASGVMNINDLEAQGIELQVAKETQGTGWKINTSPSTVEDKEILKKFLTTPPVKKIDLHFPLGLEVTARNLKGVTIKDAFDAIHKQYKKRADDELDLPYLAGFEWDKEESWTKLIVHLRKDAGMPASSKKKKAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPA2</accession>
    <name>A0ABR3VPA2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="418" mass="47459" checksum="D828CEEA06F28C33" modified="2025-10-08" version="1">MPGSSTCPCSSCFNATTQPFAPPPTQQQSPPHKESRHSGGAKGLLMFGKLRRTYSIESTASSRVGLIEAAQPVAYVSRVGRHVDPFANIAAATNTNTTTALTTAANDSSSSSDSSFTPSPHRTRESSLGTGRFFPGYPSGRQGGSAQLPPPLPPRLNFNPLAQGFALDPADAPAAEQENAVLNPLSTEFTVHRRLQRGGRHRHWNQPHMHHHHQQQQQQQQHYLYPQQYQHQPQYQQSQYRNPQQVHQNQHHHPLLLSGNPLGDYVTTTPAAIVPFSYEQQRLSNSPWESYYLQDSRFVGVSMATELLDAGGPRWPREQQQQQQQSYVQQWQQQQQREQQMREQQHLEQHQQQSHEQQPLEDDADEERGRHLGGHPQRHRAWPPPLRRRTRARVSVVGAVRRGVRASRRARAQEHFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPC5</accession>
    <name>A0ABR3VPC5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="8">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="281" mass="31591" checksum="E21615962A0204A3" modified="2025-10-08" version="1">MPKSKRARVYHLTQVTKKGREQKDKLFANIRECIPQYQHCFVFSVDNMRNNYLKDVRHELSDCRIFFGKTKLTARALGTTPEESQADGIHDLTRYLSGSVGLIFTNRAPADLISYFSNLSQVDFARAGAVAPREFVVPPGPVYSTGGEVPAEHDVPVSHTLEPELRRLGMPTRMVKGKVHLECAEPGYVVCKAGEVLDARQTRLLKLFSVCMSEFRVALLAYWSAASGEVTELEAWEERQQQLKEMREQQARQMQKGGSGRGKSGGDGEEMDEDESEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPL5</accession>
    <name>A0ABR3VPL5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="282" mass="29491" checksum="B15A49745D2708DE" modified="2025-10-08" version="1">MPLDTSTYSLALLRVDGRRWNELRRVHAQIRTQAAADGSSYLEMGNTKVMCVVTGPSEPGPRRGGVAGGGGGGGGGAGGGTGGSGGKAEVVVSIVIAGFSSIDRKRHGRNDKRTAELQTTVANALAASLHLHLFPHSQIYISLHVLSQDGSLLAALINAATLACVDAGIPMTDYVAACTAGSTSTYAANDEGADPLLDLNHQEEQELPFLTVTTLGETDRVVALVCESRVQLSRLEGMLAVGADGCKQMREILDRVVRDRGRRMVLEGAVEKGVGLEDIEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPP5</accession>
    <name>A0ABR3VPP5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MICOS complex subunit mic19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19905" checksum="89011CD829AF6712" modified="2025-10-08" version="1">MGSSASKQDSAPHVWKGSAPPTGVSQHLVESIEGSNETDVSRLQALELHIQERVAAELKRLRAQETEGLREAQKKLSELPAADEDQQQDDSTHQRQLTGPTRHEVSKAIDDLRAKLEERRQMRPLPEGVERARNEVTRCLRENDRRPLNCWREVEAFKEEVRRLEKGWVDKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ50</accession>
    <name>A0ABR3VQ50_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="147" mass="16614" checksum="FD61166AB3376143" modified="2025-10-08" version="1">MALKRINKELADLGRDPPSSCSAGPMGDDLFQWQATIMGPADSPYTGGVFFLQIQFPTDYPFKPPKVHFTTRIYHPNINANGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRQKYEQTAREWTRKYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ69</accession>
    <name>A0ABR3VQ69_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="50"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="185" mass="21130" checksum="4A231E9E5BCE8DD1" modified="2025-10-08" version="1">MGSRHGLRWNAENGARQLETSEGPMGMKLSSNPNPAIPQPEWRVLTSEARLYTFSEETKAHLRKFRLGTSRAKDPQAVIYLIDKQTKEIRLDEDERVYTSLDELAEDLPDHSPRFVLLSYPLTLPSGRLSVPYVMLYYLPTTCNSELRMLYAGAKELMRNTSEVTRIIDLESTEELEEIPDKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQC1</accession>
    <name>A0ABR3VQC1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="33"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="641"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="730" mass="82855" checksum="EB21C0966E7C5324" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQL5</accession>
    <name>A0ABR3VQL5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="128"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="423" mass="46564" checksum="D27F057013807B91" modified="2025-10-08" version="1">MSGYPGRSYHGAGYNGGYAPPPQPQYAGQPQYPGQGYYPPAPPSPAPSYGYSSPGAYGYQQPPHPPHTASAQSYPPPQPPPPNNYPSPQMPNVNRNQYVHHLPPRPPQTPQHYGHGQFAFQYSQCTGRKKALLIGINYFNQRGQLRGCINDVRNMAAFLVTYAGYRMEDMVQLTDDANNRDLNIPTKENILRAMEWLVKDARPNDSLFFHYSGHGGQTKDLDGDEDDGYDEVIYPVDFRQNGHITDDEMHRIMVRPLQAGVRLTAIFDSCHSGTALDLPYMYSTQGILKEPNLAKEAGQGLLSAISAYSRGDLGGVANSVMGFFKKASNSEDAYARSLAIKASPADVVMFSGSKDDQTSADTTIASQATGAMSWAFITALKKNPQQSYVQLLNSIRDELQTKYAQKPQLSCSHPLDTNVLFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRD4</accession>
    <name>A0ABR3VRD4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="34678" checksum="4A728A1B5FB4D700" modified="2025-10-08" version="1">MKNNPGARDPLSLRPQGVYGYAFIAARVGEIVANVVIVGILSHFIHTAVSANRAISVPLVVILTFSALSLLWTLVSCTGYSRRCMAYKFTWIADLVLLIPFLVLAILLGRPLDGVQCAAVSSEGGLAVGLGPSNNRATAIGSDEDDDIDFDLDLDVDSGSGSGGSGVIHFPTDGRTTCTLLMAVWGLLLVLCILFPISALAVKLLETSEKGARAGKASLDDASYSSYSDQGSMMSEASGEGVGEGRNWFRPTPRAVPGPGEQRMMYPDEERGGYDDAPDPVTAAERSSAWGDQLILNRPVTLGPDMGYGPMSQPPPVMMAAGPYGRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRH1</accession>
    <name>A0ABR3VRH1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="378" mass="42304" checksum="765CD676482BE05A" modified="2025-10-08" version="1">MAPPEEEGARSPTHHIELVDGNSTHRHDGEASPGLRDSKGWDGKLRVPKSTALANPEALSDPEYSDEDNVVPGEEIAADEDLLDGEDPDTDEVILTHCRIKSIPALHLERFKNVARICLRQNLIQDIEGLCCLAPTLTDLDLYDNLISHVRGLEDLTNLTSLDLSFNKIKHIKHVSHLTNLTDLYFVANKISKIDGLAGLTKLRNLELGSNRIRQIENLESLTSLEELWVAKNKITSLTGLAGLPNLRLLSIQSNRIRDLSPLRDIPQLEELYISHNALDSLEGLESNTRLRVLEVSNNRIASLKGLGPLTELEEFWASYNQIADFAEVERELGDKKKLSTVYFEGNPLQLRAPALYRNKVRLALPQVRQIDATFVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRS8</accession>
    <name>A0ABR3VRS8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_41</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="336" mass="36100" checksum="25328F6E3C6BD83D" modified="2025-10-08" version="1">MRGIQLAKYVKGPHELKVTDLPDPVPAPDEYLIEVHAAATNFFDILQIQGKYQHQPPFPWVSGAEFAGIVLATPANSKNPKFPVGSRVFGATQGAYATKAVAKEVSMLAVPEGWSFKQAAGLFVTAPTSYGALVVRAGIKAGDYVLVHAAAGGVGLAAVQIAKAFGATVIATAGTKRKLDIAKAFGADHVIDYRDDKWPELVKKLTPKNRGVDIVYDPVGLVDKSTKCTAWNGRILIIGFAAGTIEKVAMNKVLLKNISLVGTHWGQYANFEKETVVTVWEGIMKLIKEGKFRGTEFTDQEFVGLEKVPDALAALGGRETWGKVVVTVPQEGRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2A3</accession>
    <name>A0ABR3V2A3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000520">
        <property type="protein sequence ID" value="KAL1835867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="562" mass="64088" checksum="F7B428CC5F6A9067" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2G6</accession>
    <name>A0ABR3V2G6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000569">
        <property type="protein sequence ID" value="KAL1835676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24071" checksum="CC6867BF64D8555F" modified="2025-10-08" version="1">MNATTSNNPVQQGPSTAILPAPNVPSAFQDFQKIEEALNQLEATIQAAKQTTPTAIPPAWKAQAKYIRKMLEQIKAGIQTREQAELVGSQRVGSQREPLSFPPPWDGDKATFRAWRAAMSYIFKVDKEYLGSNEDQCAWLFVNLSPEAQKVAAPYYGNGGSEKHFNPEAFLDHLEWRYKISWYEEDMRWKRAQDIMEQRFQRARQFSQGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V344</accession>
    <name>A0ABR3V344_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000449">
        <property type="protein sequence ID" value="KAL1836190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF3">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="259" mass="29006" checksum="EA725BEBB73C8105" modified="2025-10-08" version="1">MGQFFETIPEHLMTWILEQKMFWVATAPLSGSGHVNVSPKGGSYFGLLNNRTFWYMDLSGSGNETISHLYESGNGRITVMFSAFHGAPRIVRLFGQGSVLERGTEAFDDFVKKREIQVIPSSRSIITVNVHQAASSCGYSVPMYDFKRFRETLNEVFAKKEQKLKQGNVEESRERYWALKNAYSMDGLPGMRIGLETAKKEHITPIPKMVGPMAPRAYRREGRFNAWHLVLVAIVSALCTATALPVLQALARRATLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V345</accession>
    <name>A0ABR3V345_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000448">
        <property type="protein sequence ID" value="KAL1836203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="513" mass="56854" checksum="4F7C46A1269BE89F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3D6</accession>
    <name>A0ABR3V3D6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000536">
        <property type="protein sequence ID" value="KAL1835788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="122" mass="13415" checksum="2AD92190029DF70C" modified="2025-10-08" version="1">MGSSPALHPQRSGDETTSTDEKPGVTAPAVAGEREEKSGTSTPPRLQPPELISKLTAEEREQLEKKLKRKIDLRLLPAVIIMYIMNYIDRNNIAAARLAGLERDLKLTSTEFQTAVSILFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3H3</accession>
    <name>A0ABR3V3H3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000427">
        <property type="protein sequence ID" value="KAL1836339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF6">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="286" mass="32701" checksum="B2144A4F19228D92" modified="2025-10-08" version="1">MPGEKKSKKRRGQPGQPQPGQQLPEQQQPEQEHPEQEQSEQQQPTPAEPEQPPHHTTAEEEPEDDAEAGPATEQPQQEQAENNNDEEYSEDDPEAENQRVFEDDYQQPDDQSKIPETTKPGEASEPPSPADSPKDEPVPALQQDDEATQDGPEKSPTLSQPPTPTAADEKPQPNFMQRQNTKTSVQELERRPHSSRKHRRDYYNDEEEEEDDDQAYSDDDYDDQVALQQQQKQMMMRQQQQQQQQVAQPQKDQGGKNPLKLRLDLNLEIEIELKAKIHGDLTLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3L5</accession>
    <name>A0ABR3V3L5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000476">
        <property type="protein sequence ID" value="KAL1836036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="214" mass="23621" checksum="E7685BD9A18921E9" modified="2025-10-08" version="1">MVGIGLQSVGLVKSNSLVPYHFFLIWMLALLSTATHNAALLALVQDFKRDWVLRWMRQFLMFANLVLSCVYGIYVLQSKVRGLPNTLPIGCVWELSSSESNVGGLDYVGTIVTIAGNCVVFGLATWYLQSRRQRWYKAVQIAGLILMLGIAIGATVRAYLLSQAFGAPDVKLSDEGEKQWSFGQLLSLLMLDEDKQALFDGELSDQSAVEHGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V424</accession>
    <name>A0ABR3V424_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000448">
        <property type="protein sequence ID" value="KAL1836201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="62"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="424" mass="46616" checksum="4B89394CE53CD0B7" modified="2025-10-08" version="1">MIPLRPVPCRLLADCAGRHPSACLVSAVSRPAWRQSQTSRRPPLRHVFSGTARPARPKTALFFPGQGVQKVGMLTPWIEAFPATAKPIIEEIDHVVGYKLSDVIQSGLSKTLNLTDYAQPAIMATSILILRILETEFGFRTSERVDVTLGHSLGEFAALVASGYMHFQDSLHLVQQRAKAMSAATRRAEEEYGGEYGMVAVVTEPAYMQSLVAAIHKFVGSSSSPDSSEDRSPIDQVLIANINSKNQIVLSGNIERIKTLVAHVRQFLGHDPRAVRLKSDSPFHSPIMRPAVAVVRDILSGTSRVPGREGEDMVSWPDDAVPCVSNVTARPFESKAQLKDLLARQCLETVQWWDSIKYLDQEQKVRRWVGIGPGKVGRNLVGKEVGMRGKDKVKGGGVWAITDPSEIEEVLIGLQETEDLVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V430</accession>
    <name>A0ABR3V430_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-dependent oxidoreductase-like enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000397">
        <property type="protein sequence ID" value="KAL1836548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="61998" checksum="AB94B3D4465A1432" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V480</accession>
    <name>A0ABR3V480_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein 33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000395">
        <property type="protein sequence ID" value="KAL1836573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="23975" checksum="966FCF13F11069B5" modified="2025-10-08" version="1">MASRGVSVLKFVGTVSLGVLTGVSYTLSSLTIPALLTLPSASAAQRALDALSSAATRHLRTIASVSSTAFALAYLFSPRPLRHPYLLYSSFLVLTSSAAASDLAAPYLLFLGPATSPGQSSQSARAAAVATAAAKKERERRAAAARARMEASYEVLGSMGSDAHSEGSAGEELESTEDVEVNGEEVRVEVEQFLKQQIVRGAVAGAAFLLSIVGIWGDGVATVYGPAVVIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V490</accession>
    <name>A0ABR3V490_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000393">
        <property type="protein sequence ID" value="KAL1836588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="968" mass="106682" checksum="5C1414F857004F64" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4D7</accession>
    <name>A0ABR3V4D7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent RNA helicase DBP8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4863</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000387">
        <property type="protein sequence ID" value="KAL1836629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="174"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="386"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1836629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="62858" checksum="764ED444A006C36A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4E8</accession>
    <name>A0ABR3V4E8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000386">
        <property type="protein sequence ID" value="KAL1836633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="274"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1824"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1896"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2504"/>
            <end position="2617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2637"/>
            <end position="2804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1908"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2511"/>
            <end position="2540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2575"/>
            <end position="2596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="2601"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2641"/>
            <end position="2661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="2662"/>
            <end position="2694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2744"/>
            <end position="2759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2767"/>
            <end position="2789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="3161" mass="345979" checksum="15E73EB3BA52149A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4K7</accession>
    <name>A0ABR3V4K7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="10">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4787</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="10">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="10">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000378">
        <property type="protein sequence ID" value="KAL1836693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046974172" description="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial" evidence="12">
        <location>
            <begin position="20"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="13">
        <location>
            <begin position="1128"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="1249"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="781"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="964"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="791"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1005"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1035"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1060"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1836693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1345" mass="149330" checksum="1388CC9B8E159C22" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4L3</accession>
    <name>A0ABR3V4L3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000400">
        <property type="protein sequence ID" value="KAL1836522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12396">
        <property type="entry name" value="RRM1_Nop13p_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034225">
        <property type="entry name" value="Nop13/Rnp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="138"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="266"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="500" mass="54597" checksum="D8ADD7F8B69F248D" modified="2025-10-08" version="1">MGKKHRPEKGLADEPTEVSANKQPADSTSKTKSKKRKAEPAEMEVEPTQAPSEEHPDDSSSKTKSKKRKTELAEIEVDLSLPEPPSKKARRLLKKGKALPAKPQSDDESDGEDREDGAADGGKEGKDGKKKKKERSPYGVWIGNLRFTVTKADLRKWLVDNSGGAITDDLITRVHMPMTKPAPGPGVKKGPENRGFAYVDFSTYEANVAAIALSETEWHGRRLLIKDAKNFEGRPQKEELPVVGADGTAVNGTAAASDKSAAKGSTKIFVGNLSFNTTEDDLHAHFEKCGKIRWVKVATFEDSGKCKGYGWVNFEEPAAAAWAVKGFVKVRETVESLEDFVEDGQKDDGEEVKANGEDTTANGEAEDDDDSDSDSDSSSKPAKSKPPKKKPAKEPPRTRVRKWWVNQLLGRNLKIELAEDDQTRYNKRFRKGGAKQKQQKEQQNEGGGEEKPTQTGGKRSSNNNTSSSDKGGGSEKPVDINVARLTGAVVAHQGKKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4M0</accession>
    <name>A0ABR3V4M0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000375">
        <property type="protein sequence ID" value="KAL1836714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="89"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="524" mass="58391" checksum="9E770CAD31587246" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4S3</accession>
    <name>A0ABR3V4S3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000368">
        <property type="protein sequence ID" value="KAL1836773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="237" mass="26288" checksum="E75F535E2DCD4047" modified="2025-10-08" version="1">MKKKIPATCLKRFMPKNGMAWPAANPHITHKIRTDYQIVCALRELGVRLRRREVQTELCDLVAAATELLRLKRSEAGWNAHLGEFLEELHNHHRLSLRLQPRTLKAFLAATFVARIRYRNHRTDEDPNQLCHLSREIDKFNEVWREFSSEDLDANDWAGVTVAEEDDGAGDNSQGPSMDWLLQGVVPVRSSVGTANTTTSVGSHGPVGAVMTNGAAATDTGGVGGIPQGENERDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V576</accession>
    <name>A0ABR3V576_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaminase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000350">
        <property type="protein sequence ID" value="KAL1836914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="2">
        <location>
            <begin position="119"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="1">
        <location>
            <begin position="359"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="1">
        <location>
            <begin position="528"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="1">
        <location>
            <begin position="696"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="93877" checksum="81D954BC4C8460F8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5A1</accession>
    <name>A0ABR3V5A1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000348">
        <property type="protein sequence ID" value="KAL1836933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="472" mass="51442" checksum="3BC8765E1523CD57" modified="2025-10-08" version="1">MGWDLSTWLAMGRCVQLLGSLIATASHGYLTIQIHKGRLGLSKEMVVLEFLACVMFGYSIFALALQRKGRRPRKTSWMTGFVICDIVLCMALLVVVNMLARAGLPDHCGGITRHDFLPGDAPNKPEDGYTTIRFSDEASGRRGHLDQFCSLERAYYVVANALMYVSALLTHAPSFLRPLTSMLPISFTYMFTVTATILRVLETKYTKNTKVHEMLESLERAEAIQLKILDASPSPLPRHREPQAHSHPPPLSEGIITRTASLRSTRTAATSVAGSHNPYAYAMLPNPRRNPAVGTMAIPRRGIPPPAGRPSSPTPSTTTTGSTAIMTQPSTPPPPFSTLPHDQDAAAAAALVADGMQHRPHHHHHHPSQHQQHIYHHRHYLPPGMPMLSEEVPLPGPKPGPSPSSSSSSSSPTLAPSYSAPSYHSDEEDPAAAALVSDGMRHTRESSLPPYQPRQQGSGEMRLSGFGKGQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5G3</accession>
    <name>A0ABR3V5G3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">VTJ49DRAFT_4440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000345">
        <property type="protein sequence ID" value="KAL1836961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="275" mass="29963" checksum="1FF04203F9B136D8" modified="2025-10-08" version="1">MGYLDDEIKRLQGIIANIESRVQALESRQLGGAQKKTPEEVRMILIGPPGAGKGTQAPKIKEKFNCCHLATGDMLRSQVAKKTPLGLEAKKIMDAGGLVSDDIVIGMIKAELENNKECKGGFILDGFPRTVPQAEGLDKMLRERKQSLQHAVELQIDDELLVSRITGRLVHPASGRSYHTTFNPPKVPMKDDVTGEPLIQRSDDNAEALKKRLATYHKQTAPVVDYYKKTGIWKAVDAAQPPQQVWKSLLAIFDGDKAKAAAAGSGRLGKLASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5K3</accession>
    <name>A0ABR3V5K3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase I-specific transcription initiation factor RRN6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000337">
        <property type="protein sequence ID" value="KAL1837028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="126"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
        <location>
            <begin position="841"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="919"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1036" mass="114385" checksum="A54DBA0E01442CC2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V633</accession>
    <name>A0ABR3V633_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000355">
        <property type="protein sequence ID" value="KAL1836881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="718"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="991" mass="110546" checksum="17B97BF838533574" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6B0</accession>
    <name>A0ABR3V6B0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_4548</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000357">
        <property type="protein sequence ID" value="KAL1836868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="17">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="18">
        <location>
            <begin position="542"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1836868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="748" mass="83382" checksum="BF8C95D4C0EEAA54" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6I1</accession>
    <name>A0ABR3V6I1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000320">
        <property type="protein sequence ID" value="KAL1837182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047443954" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="46447" checksum="CF4CA98D98F2000E" modified="2025-10-08" version="1">MRRCRLALWAASLLAAHAAATAIPFRELFARQSTCAPDHSRCQHEGFPDYFCCPADQACIPLAGNTTLLCCPEGSTCEAIEPVPCDISLQDGERHPDTVIKTTALGGTLKRCGGQCCPFGYSCSGNECIIDEDQNAVPIETRRPTSTRRVEQPTATSSSAADPTSTPDESDETEDIEDSEGVDDGDEASESNDTNASSGPPVAAIAGGVVAGVVVLLIAAAAAFFFLRKKGKLPGFLGGKRGSDSGKGPKLSRSTSSFGNLISNPIVSEHSTFRTDFARGSPPQPSLSATAVGDQEPDSVTGALIDSNLNSPETGAIGQASSTMPPIAAQMMGRQQQQQQQQYQAYATGAGGGGYAGGYGALDPPQTPRGQQYREPSSVSINVFADPNITPDRTPENNSGTKYGRYSTNTTFTQMLDSADLGGMARGESYIAYSPDVPPVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Y4</accession>
    <name>A0ABR3V6Y4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000320">
        <property type="protein sequence ID" value="KAL1837181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="123" mass="13580" checksum="17F0C596FE10EE69" modified="2025-10-08" version="1">MLGRCVASGSETLWAAAVSLIGWRFLWMLFSSQRLAESLQNQNPTRHRICVWAGGLSQRTEDSNAAFTRISSPAVVSPVIHTAAPAGRWAGIPAPDTTEKRGYRIAQSYVKRKDPGGRRLGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7P5</accession>
    <name>A0ABR3V7P5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000264">
        <property type="protein sequence ID" value="KAL1837771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="91" mass="10517" checksum="0E63BF13CC0EE614" modified="2025-10-08" version="1">MAIKVGTCLICRAGFRRWLESMHMCNFDEARSRRGPGYIFTIHIASNMKDPNSLFMMALRKLVEVSRFEHHDAKIEGNMVDWTVTELGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7T7</accession>
    <name>A0ABR3V7T7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000263">
        <property type="protein sequence ID" value="KAL1837787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF28">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="325" mass="35989" checksum="36FEF343E9EBFBB5" modified="2025-10-08" version="1">MSNTKLIVVTGATGAQGGGVVNVMKKTPGWRIRAVTRNPESDAAKQLMADGTIEVVRADYDDEASLGAAAIFAVTNFWEPLFPSGASQHEAGAIEERHGMNLARAAAQTSTLEHYLWSTQPSAREATAGEHEVPHLDYKARVDERIREELPELAAKTTYLYFGYYPQNMVYFPLLRPVEDPETGSHIQTLPMDPDSKILVAGDMTVNPGIWVRQILATAPAAEGKYTRIALERLSFREMMDGWSAATGRKGVIRQVSEEEWTRMWGVAGTELAWQFRFGEMCDPWAKREGDGKEFVGPEELGIDPKEVVGFEETVRGLVRKGLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8E5</accession>
    <name>A0ABR3V8E5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000252">
        <property type="protein sequence ID" value="KAL1837910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="259" mass="27669" checksum="6518BFB98DF18D52" modified="2025-10-08" version="1">MAHHTPFKSLSPLSWETDIAPHLDDNNDASSSSQALASLLTTTFADAAILIDSIPSSPPSAATQPSSKTRARSKTDSAVGPPLTPLSSFSSSRKGLVGKEKGGKAGVEDGEKKEEKEDRERDATVAKLRSEWKEVTQGDAHGISVYKMIAKDGKGAWFARRSLHLGGGKGEFEKWEAALRREMQVTLGRVEESPGNEPGTGNIRGIGAERRVDGRVCEGGSVDFGSVVNGGGPRGPSLWPLVVLHLWDLEFDSQLEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8G2</accession>
    <name>A0ABR3V8G2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000243">
        <property type="protein sequence ID" value="KAL1838026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="9">
        <location>
            <begin position="429"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="613" mass="67406" checksum="EDFE3CB7B7C2F5DB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9K0</accession>
    <name>A0ABR3V9K0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroxy-acid dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000218">
        <property type="protein sequence ID" value="KAL1838372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="7">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="6">
        <location>
            <begin position="226"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="8">
        <location>
            <begin position="552"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="84094" checksum="6A254791C2C26C35" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB19</accession>
    <name>A0ABR3VB19_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000206">
        <property type="protein sequence ID" value="KAL1838586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="261" mass="29997" checksum="82119315C6FA581C" modified="2025-10-08" version="1">MSWAGFKKNVNRATTQVMMKTGHVEKTNDRDYEVEERRFRTMEAASLRLQKEAKGYLDSLRAMTASQMRIAETIDAFYGDSGAKDGVSRSYKQAVEDLDAETIKALDGPYRTTVLEPIQRFCAYFPDVNECIKKRGHKLLDYDALRAKVKKLVEKPDKDVTKLPRAEKEMEMAKAAYEQLNEQLCSELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDPDTREQYAQGQLDSRVEQVLQEIRELSISGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBD8</accession>
    <name>A0ABR3VBD8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000198">
        <property type="protein sequence ID" value="KAL1838696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="138" mass="14481" checksum="8534CFC8D93AEC37" modified="2025-10-08" version="1">MADVGNFPLNGDPNLDTGDEIDGTSAGAAGTSTGGVSLSQGALIAIIVVVVVVALAGIATSALFFVAKKREWTVKETLRRSAKRVATALTPRRSEFPRSVKEGRNGRFDDVPPTPGIKPEHLDLEKGQGGKSKKPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBF5</accession>
    <name>A0ABR3VBF5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000172">
        <property type="protein sequence ID" value="KAL1839168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="77"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="694"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1129"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1176" mass="132422" checksum="482D83F601E9CC3D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBP9</accession>
    <name>A0ABR3VBP9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lumazine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000173">
        <property type="protein sequence ID" value="KAL1839137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
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            <end position="107"/>
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        <source>
            <dbReference type="EMBL" id="KAL1839137.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="218" mass="23137" checksum="0F186763F45B2E90" modified="2025-10-08" version="1">MFTGIVEEIGTVAELNPNDATGGTSLTIALSPDSTLLSDAHLGDSIAVNGVCLTVTTFTTPSDGTPPSFTVGIAPETLRLTNLGSLTTGSRVNLERAVRADTRMGGHFVQGHVDATAKIVDRRPDGNAITFRFAPTNPGLLRHIVYKGFIAVDGASLTVTAVNDAEGWFEVMLIAYTQERIVTAAKQVGESVNVEVDMTAKYVEKSLRGYNPGYHAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">VTJ49DRAFT_1798</name>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Drula E."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000171">
        <property type="protein sequence ID" value="KAL1839179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1839179.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="805" mass="86671" checksum="67A6589EB1EA9359" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
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                <person name="Hansel C."/>
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                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAL1839499.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="224" mass="24424" checksum="19E0A74283169135" modified="2025-10-08" version="1">MSPIGGAYLSALDANAIFLGDNNANTNPDMSSQSEKQLDEQQQPQLLHPVPQQTWSSSWWSTTTSWLFSSPTGNDTSISSYNTYNTTTTSAAPTTLRDHAISVLNPTQQQQHQHQQPEQYQDWSQQQQPQPPPAYSAYPPSTPGLLGAKEAQVTVTDPTVPAEVANHFAAVQAAENRRLQRRLKRRAGVDVLLLVAALGFLVWKVGGGLFALAGRGVDGEGEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCK2</accession>
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        <recommendedName>
            <fullName evidence="10">MYB DNA-binding domain-containing protein</fullName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="Singer S."/>
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                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000157">
        <property type="protein sequence ID" value="KAL1839434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="335"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
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            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42293" checksum="F82B0DE4E13EF94A" modified="2025-10-08" version="1">MAPTLSLHSTATPAVMPIPDCMQKEPIGAPSRQIISIQSPATSQSEQLWRNPCVGDTLAGNYRVGPDYNVNYAPQEPHAGEQAQAPHGYDAHQHHRASLQHTGPPAPPPPPPPPVHEQPSHQPHHGLPQHHYAPAHHPHPILTDPAHLAGHHPSARHMGHPGHPGPSHFGAGPSPHTVVAPLYPTLTPSHGHTAGVKRPRPDDLDLSVPGMPDLGNTDLESMQQTPMSATATTYGQAPAPPTHHHHRLPDTGPPAKMMRREGESSSGGGGAPSMVGQAGMPPPAPRPKGPKLKFTPEDDQLLIDLKENKNLTWKQIADFFPGRSSGTLQVRYCTKLKAKTTQWSEETDQKLRMAIQDYENEKWRIIANKVGTGFTPAACRERAAQLLGENAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3VCN6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000155">
        <property type="protein sequence ID" value="KAL1839467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="524"/>
            <end position="554"/>
        </location>
    </feature>
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        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="233"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="429"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        <location>
            <begin position="260"/>
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        </location>
    </feature>
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        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="605" mass="64839" checksum="8167BF621E7D0AFA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCT4</accession>
    <name>A0ABR3VCT4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000180">
        <property type="protein sequence ID" value="KAL1839013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="344"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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            <begin position="44"/>
            <end position="54"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
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            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="372" mass="40774" checksum="0A842C33B0BEF9AA" modified="2025-10-08" version="1">MPIRNPFARRPSPAAANPAIQDEKRAMGGDPAHPGFERVDTVGATRTSTSSVFSSIRGGRRSQDTGEYKMSVVDDSGVYLPPSPVEREPVWPRRYLSRTSSDHRRSMSSGGGDIAQFPISRESFDSYRRSFVKLTNLPVIRGKQDITARTPVRHGHRPRQSLDSHPHMLPLFSTCSDLSSASSRSTTSWGASTHITTPEEDCEMRFEEVQLDDDENEEGKDRSGAEDQQQKGYLSGLRLGRGLMGHHDEQEQHQQHQQQKKRNLFSFGRSNADTEHEYPTPDLHPMDASRTAFEESPLETTTTSASTNPSSSASTGMSRFLPPLPVISLPLGGGKKKVAGGSSAQEAELKFMGMSSSAAGTTGTLQTQEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCW4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1298</name>
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    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="77" mass="8305" checksum="DE357E0147B5C6AF" modified="2025-10-08" version="1">MAPKRIGGGSRRSYNPVTNIYNALFVSENAPVVRSIAAFGVSLPRQARSRMRQFADSGQIAVTLLSTGVAEAWLVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCY7</accession>
    <name>A0ABR3VCY7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1319</name>
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    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="623" mass="68172" checksum="AF176486593AF070" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD00</accession>
    <name>A0ABR3VD00_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000176">
        <property type="protein sequence ID" value="KAL1839088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="8">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="293" mass="33023" checksum="0709F01150519A71" modified="2025-10-08" version="1">MAPPTGKRVKGVQIFRPFVYGTTAKPFDEKTNPKPPGVPDDHTHSWTIFVKGIDDVDITYWLRRVQFKLHESIPNHVRMIEGEKGKPFEVHETGWGEFEIAIKLYYVPESAEKPQTLYHHLRLHPYGRTEAEKETMRLAGGEIISWAYEEQIFNEPYEPFYEILTSGAMPPAHPLPPSSASTPTQPGHHKSLSKSSISGGGKSKDKDKDKEVQMIRSEGGVLERSAMIPLVNRPGQPFSRETEQVEIKKLQEAMVKVDEMVRKNKEEVQRKEARLRELKAESAAAAAAATAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDR7</accession>
    <name>A0ABR3VDR7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="857" mass="92673" checksum="32BF0A3531933FBE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDU4</accession>
    <name>A0ABR3VDU4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000131">
        <property type="protein sequence ID" value="KAL1840014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="500" mass="55639" checksum="CF0A68CB7E6CED4A" modified="2025-10-08" version="1">MLFQRTKKRVRGGTCGFLMAGRCLFFHSEEDRVHAERLRVQQVGELSQGLVELDVITARDLSGANGRFVGITECREVASFSKVIGGEIAVPGCPPRFTPPQQPLTIPRRTKAVNYAISSSSTPFHHFTYPFEPPLRAIETIQQCTAASILAGTDILTSAGSLTKLFRLIRNTNGHTITRFEIDLVNEGSTLIISRWEGDPQFQRTYGYGVWFERETCRYDAGDDDNDDVLKRSTSHHRVVAYSFGGLRCLVQAETDGYYCQCGEKGHPRVPEDDDDVVPVSPQSSRIPSPKPRRRSSNQSPPSRLSTSPRSPRSSFSSSSPSSIFSVLALDDPGDLLSSSSSSPPNNIPVTTTSSPTLRIHHTGRRVPSQCLVEVKTRSLKTPSWDAYEEQLYFARRAQLYVAVRQHGKFLPDGSVLTTGCGVETDGEMREWERREQDALGKVAELLKVVKEKLRGMKESGEVKVSLICENDGSGRDEGWRVRICRRVDGRGELVPEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDV3</accession>
    <name>A0ABR3VDV3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000131">
        <property type="protein sequence ID" value="KAL1840005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="133"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="324" mass="35587" checksum="BACB4B0DEEC2B715" modified="2025-10-08" version="1">MPPRLPIPLTQAARCCAAPASRPQAPSLVSLFAALSLQSRTPTPPTTATVTTPTQIRSASILANLSDNKGAYNKRIRKGRGPSSGYGKTAGRGHKGQKQHGKVKPWFQGGQTPLIVSHGRHGFINFRAPKMMEVNLEKLQKWIDTGRIDPKKQITPRELIRSNLVGNPILDGIKLLAGGKETFRTPINIVVSRASAAAIEAVERAGGKILTRYYTRDALKRLVRGEVVHTTTPLPVGPEHVNRVLGRMRHEARVSGGKKVYRLPDPTSREDIEYYRDPAHRGYLSHTLKPGESPSLFFKVPGAETAEVKAVEKERAEEQAARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE05</accession>
    <name>A0ABR3VE05_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000133">
        <property type="protein sequence ID" value="KAL1839959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="463" mass="51758" checksum="981014966723C17D" modified="2025-10-08" version="1">MPREIITIQAGQCGNSIGSQFWQQLCQEHGISQDGNLEDFATEGGDRKDVFYYQSDDTRYIPRAILIDLEPRVIHGIQTGPYRNIYNPENFYIGKSGVGAGNNWGDGYQTGEQVHEEIMEMIDREADGSDSLEGFMMLHSIAGGTGSGLGSFLLERLNDRFPKKIIQTYSVFPDTTNSGDVVVHPYNSVLTMRRLTQNADSVVVLDNGALAHIAADRLHLQEPSFQQTNQLVSTVMSASTTTLRYPGYMHNDLVSILASLIPTPRCHFLMTAYTPFTGDQVEQAKTVRKTTVLDVMRRLLQPKNRMVSTVPGKKSCYISILNVIQGEVDPTDVHKSLLRIRERRLATFIPWGPASIQVALTKRSPYIPMAHRVSGLMLANHTSIATLFKRIYRQYDGMRKRNAFLEGYKKTAPFSENLSEFDEAKEVVLDLIAEYEAAEDANYLNPDQGDGPATSAETDKRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE09</accession>
    <name>A0ABR3VE09_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000127">
        <property type="protein sequence ID" value="KAL1840105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="648" mass="68118" checksum="4A76CA7FECD28C77" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE24</accession>
    <name>A0ABR3VE24_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="262"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="570" mass="62862" checksum="F13836FDF65C8CFB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEM8</accession>
    <name>A0ABR3VEM8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="406"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="499"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="503"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="73287" checksum="61B498FADC7D45D2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF88</accession>
    <name>A0ABR3VF88_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="31"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="338" mass="38578" checksum="432BBAFC18966EFD" modified="2025-10-08" version="1">MASVPPATIYPQSHVGFDSITSQIERKLLKRGFQFNVICVGQTGLGKSTLINTIFASHLIDSKGRTQPDEVIRSTTEIQSVSHIIEENGVRLRLNIVDTPGYGDLINNDRCWDPIVKYIKDQHSAYLRKELTAQRERYIADTRIHCCLFFIQPSGHSLKPIDIVVLKKLSDVVNVVPVIAKADTLTLEERQAFKERIREEFAFHNLKMYPYDNDELDEEERAINTQIKNLIPFAVVGSEKSIIVNGKQVRGRQNRWGVINVEDENHCEFVYLRNFLLRTHLQDLIETTSQIHYETFRSKQLLALKESSAQGTGHASRPISPAEREMSRSSQRGTINGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF90</accession>
    <name>A0ABR3VF90_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000134">
        <property type="protein sequence ID" value="KAL1839943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="83"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="422" mass="47008" checksum="1BF14C2EBBEC5653" modified="2025-10-08" version="1">MDPQNQNSGQHNQHGQQARQMPAYDLSLGGHYGASAAISAAGYAPSDLYTGTWANVHQGLTGHYKDVLTAYWQHTISHLESDTHDYKMHQLPLARIKKVMKTDPEVKMISAEAPILFAKGCDIFITELTMRAWIHAEENKRRTLQRSDIASALAKSDMFDFLIDIVPREEASSHAKRASNQAAAAAAAQQSAAAQQPQIPGVGAPNHAGQHPMATADYTLGGQHMATEADYRQPQTMYPGQVQPGAPAYGQPQAQMYNVDDMYPYGAMPPQQVCTPPPHRPFSLAELRANATAEEAQQPEHLVGIKSEEMDPALTLVDPVLHPKLEPEPELQPKPHPWLDPRLQPRFRGQRWLLPRPVPMQEPEPEPELELKQEQGPDEVREAAPETELVPETNHWEPNIKVEEQAPESNHWEPDIKVEDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFK5</accession>
    <name>A0ABR3VFK5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000105">
        <property type="protein sequence ID" value="KAL1840629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046577608" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="786" mass="84879" checksum="3C56795670DCB500" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFV1</accession>
    <name>A0ABR3VFV1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="554" mass="66624" checksum="0B60BEEF42AD5F23" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG05</accession>
    <name>A0ABR3VG05_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000102">
        <property type="protein sequence ID" value="KAL1840709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="13"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="246" mass="26519" checksum="33A1B8F2738C082F" modified="2025-10-08" version="1">MSQPTDPPASAPAFIPLEANPELLTSLLRSLGLSPALSMHDVYSLTDPSLLAFIPRPALALLLVFPVSAAYESHRLAEDASLEPYTGKGPSEPVLWFPQTIRNACGLMGLLHAAGNGEARGFVEEGSDLERLIKAAEPLDPEGRARLLERDETLASAHRAVAEKGDTAAPDARDDVDLHYVCFVKGRDGALWEMDGRRKGPLKRGELDRDEDVLSDKALALGPLKFLEREAADLRFSCVALAGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG07</accession>
    <name>A0ABR3VG07_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="4">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="192" mass="21655" checksum="7AF5A781EBDE55B7" modified="2025-10-08" version="1">MFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEVGRLEILKIHSAGVQKEGEIDFESIVKMSDGLNGADLRNVVTEAYVFSRSLIPCLDRVTNPSRSGLFAIKAEREAINQDDFNKAVRKLVEAKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG67</accession>
    <name>A0ABR3VG67_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14710">
        <property type="entry name" value="bZIP_HAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="155"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="594" mass="63300" checksum="66B13AF0B47EECC8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGB2</accession>
    <name>A0ABR3VGB2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="346" mass="38826" checksum="7CD1C3DECDFD1584" modified="2025-10-08" version="1">MSTSSGTPESWISSFCSLLGHEYFAEVSEEFIEDDFNLTGLQNQVAMYKEALEMILDVEPEEDEEDEDEEEEEDEEDASGDVGDGTSRRERRHHSRVASDLSVIESSAEMLYGLIHQRFICSRAGIQQMAEKYELGHFGVCPRTNCNQARTLPVGLSDIPGEDTVKLFCPSCLDVYVPPNSRFQTVDGAFFGRTFGALFLLTFPEYDLSRSAAEAAASLGRAADEQGMINGMYACNIAPGLGRDKIYEPRIYGFRVSELSRSGPRMQWLRNKPNDMSVLDEARRFHAEHDDEDDSDDDQSRSTRYSRRSTGRRRLGGGVARYRQIQRQAQNGSPMAIETNGAESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGB8</accession>
    <name>A0ABR3VGB8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="550" mass="61464" checksum="D8A1607E8C809677" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGI3</accession>
    <name>A0ABR3VGI3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="115"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="683" mass="74617" checksum="C403858FF474BB48" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGT0</accession>
    <name>A0ABR3VGT0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF9">
        <property type="entry name" value="L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="274" mass="29333" checksum="B84F49701390A8CA" modified="2025-10-08" version="1">MAPKISFAAPLSITHIGTATAIINIGGVNFLTDPVFSPAGTTWDLGIVTLKITSTPAMSLANLPPIDAVLLSHEDHPDNLDELGRTTLDGRHVFTTVDGAKKLAPRPGVRALKPWETLPLTIGARHFEITGTPCQHLPGGEVTGFIISSPSFGNTDGKPNAIYFSGDTVYLPELVQMKERFHISVALLNIGKATAPLPTGPLVITMDGAQAAKLAREIEADAVVPMHFESWEHFAETREELVQALESAEEGGVKDRVVWLEPGVETRLVEPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGW5</accession>
    <name>A0ABR3VGW5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="171"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="573" mass="62277" checksum="99F72AA882E566EA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHM2</accession>
    <name>A0ABR3VHM2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor tau subunit sfc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="25"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="210"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="589"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="644"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="88284" checksum="FAC64142C41254E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHM5</accession>
    <name>A0ABR3VHM5_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000077">
        <property type="protein sequence ID" value="KAL1841380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="186" mass="20612" checksum="46FD50C354BFCDA6" modified="2025-10-08" version="1">MDSSDRSLDDGSGLLTVPLKRSVPRPSRLINLQGPGSLKSGRHAKPKLLCTCGLTPNLLELMRWQSMGWPPSFAIGRTAAHAGWCRCEAKLGWLSTWPCGERDGQGPPREAVGRHPNPQTSEGLMASRVSASGTEAEVHKRRREHKVWRQFKLPAALQLAVLFQCCPPLYLVHRLARHTPAIKKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI68</accession>
    <name>A0ABR3VI68_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="150" mass="17282" checksum="18529E9B1E986A55" modified="2025-10-08" version="1">MSPPRVLTHTGRHHSANLYLPSQLASTGQNASAKPATRPRRRSKLTGPPRRPSIASLRPSTPRATSKQKRKLPAKPRRRSRRSARLGARRRTRLSRICFRRCGGCRLRRELGSFKRRELDDSCTRFLSWGDWQYRRVLSSGAAPVMKLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3VI72_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="13"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1359" mass="154280" checksum="5996FA7BF4381645" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI75</accession>
    <name>A0ABR3VI75_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000073">
        <property type="protein sequence ID" value="KAL1841489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046659057" evidence="2">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="232" mass="24414" checksum="1F8648C031BAD228" modified="2025-10-08" version="1">MHLHYLSAVVLAGFACAHPLAARDAHGTEESIMSSSAQSPTPTKSANACKGTGSGGSGVNMAAAIAAIMPSSTSCDKVDFPDECRTAEQAAPFIEKACADLKPAECAATIALMGLESADLKYKHNVVPGTPGQGTANMMMAEFIAEYATDLFGADKVQGKSPDEVLALVTPDEYNFGSAAWFLKNKCSADVRSSLQTGTDEGWLAYNECIRVNGANVERMAYWTRAKAAFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIA0</accession>
    <name>A0ABR3VIA0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7237</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000080">
        <property type="protein sequence ID" value="KAL1841292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="670"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="805"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="487"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="884" mass="94092" checksum="A8014F240A55F721" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIA3</accession>
    <name>A0ABR3VIA3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32563" checksum="302FAA4010447344" modified="2025-10-08" version="1">MTVAGTTCQPGPISHGKGDVVASVNYYDDPGNGSLPEPVHIQGSTVTNKRATVSKTMTVTDITGLEDTFTLDKNGFQLIHHEFGGRCQADGYRDKAAVEAEYYPAMERLLKNVTGASRVYIFDGKTRCGPTNWHSLGPGNRTKPGPILRAHVDQSYAGAESLLRLLLPDEAETLLKGRWQIINAWRPIKPIYKDPLAVADATTVSDEDLVPARVIYPDHERETWTVKPSEAHRWYFKYAQQPDEVLLFKCYDSTDAVARRAPHTAFEDPRHTDGPWRESIEIRSMVFYDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIH6</accession>
    <name>A0ABR3VIH6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="5">
        <location>
            <begin position="144"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="326" mass="36669" checksum="5D4621C7645EF5D7" modified="2025-10-08" version="1">MTHTPDLSPTKLLLRDVNPLSNRSRIPLMPSDAAMASKLCKNRALAAALRSAKPSPSPSPSSVALRSSFSTTARLAVVNVPKDAPNPRAAPRGQVGPLKAPPVNPADKYQSKADDLHKYGAWLMSCLPKYIQQFSVWKDELTIYICPSGVIPVFSFLKYNTNAEFTQISTITAADYPTREQRFEVVYNLLSVRHNARIRVKTYADEVTPVPSVTPLYMGANWFEREVYDLFGVFFAGHPDLRRIMTDYGFEGHPLRKDFPMTGYTEIRYDEEKKRIVTEPLELTQAYRNFEGGSSAWEQVGPGVDRTPETFKLPTPKPEEKPEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VII0</accession>
    <name>A0ABR3VII0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000067">
        <property type="protein sequence ID" value="KAL1841688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046421187" description="Methyl-accepting transducer domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29445" checksum="A87EC94F720D64D9" modified="2025-10-08" version="1">MARKPLIVFLICRLFLLFLICSSCAWVGSGVAAGPAPGSGRETGLVFGRGTRGGDTGSETEQLWRRRGGRIPRGVARVAEREDERRDDDNAPTLAAEPAHIIPDGSPHPTITPPPSFFHLQARQDGQIAALSAQLAQLSEQSRQVSQASQQLSQSSQQLSQSLQQASQRLSQTEQSLASARLQASAAESASRVMSQASAEASRRADEASRSADRAITEAMRSASQSASRAVSESMASLSASMSSVLRSASQSAADAMRSAASVARAAQAEATALRVSVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIL8</accession>
    <name>A0ABR3VIL8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="674" mass="74912" checksum="5D37D096658D4136" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK93</accession>
    <name>A0ABR3VK93_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="438"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="438" mass="48270" checksum="D012F0984DF5709F" modified="2025-10-08" version="1">MPVLARRLRNPQIQLFLMTYTYTNTLEVDPTITPTASPVSATTRTYTYMDLEIVSVFLPAGAVKSSDLAPTTTKSYVSGVVSYYAVAYTMTAPSSCPTSFEVVTQSVVYVPAEVWPYLSIQSTATSVHTRWDETYITYFIEPTAVAPSERPDPTSNWDYSYYVRSCRNPTATGAAYWGPGSSSGSDYDDWDWSSVCSAYTGCVKLATWVIVIATIIPTLFLLGFLESYFWFRRLMLGKTALRLGTISWCLISLWFILLTRKADSRSPEDQALMRNYWKSLSFGTRIKLWFKHGFRWRYPVELLGNPDGTTVVVVPQPPADGTAPAGQFPPPPPGSDPSAAATVPPTDEKATQAQTQEQQQQQPPYPAQPYPGQQPPQGYMWIPAPPQNAYVAPGSQPVVVPQYPPPPSVSPVPTTGTPPPPVYGQQPPPPPPGTQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKB8</accession>
    <name>A0ABR3VKB8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000051">
        <property type="protein sequence ID" value="KAL1842196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="82396" checksum="EB0B58D012106269" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKH9</accession>
    <name>A0ABR3VKH9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046306783" evidence="3">
        <location>
            <begin position="23"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="677"/>
        </location>
    </feature>
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        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
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        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
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        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
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        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
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        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="677" mass="70518" checksum="0AA7E75CB33350F8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKL9</accession>
    <name>A0ABR3VKL9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="225"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="430" mass="45527" checksum="95BE4442A3017E88" modified="2025-10-08" version="1">MTSRRSARLAALANSPTKPAAPPAPSAIPLVSSRKRKVATEAPAVDGSDPGSAAPSTPRKRRARAADLGDPPDTPTPAAASLLAEPVQTPSGRRARHAAVARLADPTRTNALLRSPKTSRIIAPEPASDEVAAAAKLNSAPSAAAAAMAAVDGGGGGGVGGAGGITGAVDHITTSATILSEALAHLIRIDPRMKPLIDRHHCRLFSPEGLAEQIDPFEALCSSIISQQVSGAAAKSIKARFIALFNQDDESSGSIDDGHDIINPHPDNNNNKKRFPTPEQVAATPLDRLRTAGLSQRKAEYLVGLAQEFASGRLTAQSLAEAPYEELVERLTAVRGLGRWTVEMFAMFALKRLDVFSTGDLGVQRGMAAFVGRDVAKLKNGGGGGKGGGKWRYMSEKEMVEISERFRPYRSVFMWYMWRVEETDISTLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL97</accession>
    <name>A0ABR3VL97_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000067">
        <property type="protein sequence ID" value="KAL1841681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="287" mass="31054" checksum="ACA6C6B113135E46" modified="2025-10-08" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTALGIKATNGIVLATEKKSSTPLADPSSLSKISLITPNIGMVYSGMGPDYRVLVDRARKVSHTNYKRIYNEYPPTRILVQDVARVMQEATQSGGVRPYGVSLLIAGWDEGILPEEEVEQQQQGKEGEQVPIGEKKSKLAGKTGGILKGGPMLYQVDPSGSYFPWKATAIGKSAATAKTFLEKRYTEGLELEDAVHIALLTLKETIEGEMNGETIEIGIVGPPADHLLGVEGVEGAVGPRFRKLTPQEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLF1</accession>
    <name>A0ABR3VLF1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribose 1''-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:58753"/>
            <dbReference type="EC" id="3.1.3.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.84" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02901">
        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="8">
        <location>
            <begin position="112"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="308" mass="33072" checksum="83A4AD76DDF6C3AB" modified="2025-10-08" version="1">MPEKRPADSGAAAGGMRGFKQTKLNFRPLTSKTNQEKSAATDPQNEPEESSPKPKSDTPSGDDSNKPPNDQQRQQHQPADDPAKANPTTSGSGSGSGSGSGPTTTGTPASTSTPSTSNTRYRIRIVDRPGDLFSAPPGAVLIHACNALGVWGGGVALAFHDRYPEAYRVYRRHCLKSTPERLAGTALLIPPPPASAGEEEEEEGGLEGHYVGCVFTSRRFGRGVDSPREILRLTVPAMRDLMRLVAEEGERVTEVRMCRINSGIFNVPWEETKKAIEGMVLGGEGEPVPAGVRDGVLEVVAWERPEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLN6</accession>
    <name>A0ABR3VLN6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_4656</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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            <begin position="301"/>
            <end position="507"/>
        </location>
    </feature>
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        <location>
            <begin position="671"/>
            <end position="835"/>
        </location>
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            <end position="702"/>
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            <end position="728"/>
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            <end position="759"/>
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            <end position="793"/>
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            <end position="805"/>
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            <end position="832"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="913" mass="100944" checksum="5C336FCEE5E514AC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMM3</accession>
    <name>A0ABR3VMM3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
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                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1843150.1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_fung"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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            <end position="77"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843150.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="927" mass="100647" checksum="F3CCA6654DB0A33E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN80</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_5345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="763" mass="82636" checksum="71E2C897F803A012" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNE7</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_1560</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="103"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="625"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="767"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="645"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="773"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1843450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="820" mass="88632" checksum="D5C38459F68FABEC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNG9</accession>
    <name>A0ABR3VNG9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF2">
        <property type="entry name" value="CELLULOSE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046067393" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="280" mass="30249" checksum="99227FAAE5805699" modified="2025-10-08" version="1">MRFSLAALIAGLAATASGQKVRVMLLGDSLTEISCWRPMVWNQLIQAGLADKVDFVGGQNSIGPSCPRPAGFDANHEGHSGWQAYDIARQHITGWVQTHRPDIVQFMLGTNDVNIGKRNAQSIIDSYTTMLRAMRAANPRVKVIVDKIIPTSWSDATIEQVNNLIPGWVQSNTTPESPIVIADCSRANGYTNSMLAGDGVHTNQQGDEFIARQIGPKLIQFVNDVLGGSDPAPSSTAAPPVVIPTPPPVTLTTVVVPPQPTANCASRWAQRQNDWYSQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNJ3</accession>
    <name>A0ABR3VNJ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4371</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="105"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="333" mass="37793" checksum="AF7863D8DA761B83" modified="2025-10-08" version="1">MADVESTIATKRKATPEPALDDIVGKRARLEHADGTPPPANGAGNGTANGTTDGPAPTKEEDRYPPAGSPPRTRPEAEAQTRRLSDQRRPSATSGPPIRRQVTLEEKKRGQRLFGNLVSTLSRTASGPQQQRRLEIERRQQGRAQQRRAEDEKRKVERLEHLKRSREIEQVNLEEREMHTRHRTILSRARSLVTRSEPKIYYLPYKLTRDQEDIIDDQIRDAEETIARERREFKLRKEQRLKELGVEPPVRSPSPPPPREQKEQSKAAEPEIQPPSASDQATVGEPKPAPQDTNPDTVATTAPTKNQTQQLQDKEHDEHGDEMVQDEEDVVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNW9</accession>
    <name>A0ABR3VNW9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="108" mass="11103" checksum="CDD8FBECAE18220D" modified="2025-10-08" version="1">MAITTAIADLFHSATELLSSLFHAIYAVIHTITTQIIALFTGILSCIGDLGGALADALEGVIRFVLNNAPILAGLAAAGYIYLRVIQPAQTQGAGGRRNPAGAAKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP41</accession>
    <name>A0ABR3VP41_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 11">Catalase</fullName>
            <ecNumber evidence="3 10 11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_4354</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 11"/>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="13">
        <location>
            <begin position="42"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1842716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="703" mass="77807" checksum="452BF5E5BC22DF57" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP61</accession>
    <name>A0ABR3VP61_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045084721" description="Integral membrane protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22572" checksum="297F22FC5B652DA9" modified="2025-10-08" version="1">MTHSPQTTLFPIAALPTCVSSCGVLYDVNGACVPPAKPTADATTYGKCFCTDPRVTPFATGTTGVCDEACAANPNDLTAIRNWYTSYCDQVTAAATAAPTRQASGGGGSWLDNHYQWVIFLVIMVVAIVGIWIGACVWRRRYLRKKDREYALGTNLARATESGRIVPNDSTASVHLPRSGMFDPAPISSAAVYGEKETKSKRKWALGSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP74</accession>
    <name>A0ABR3VP74_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_94</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1843713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="168" mass="18106" checksum="FCCE72A8802F9144" modified="2025-10-08" version="1">MSSAPSKSGVNVSAAPALPDAAVRLLPVLAALSLQFRTRESAGQGPAKRESKTSRRTTRTRERSESTNTLPKVLRYSALGLGVLYGFYHQRSITAAQKAAAAQREYEHKQKLINQAKAAYAKSKQPAVASASSQEGELFIAYVPWRGVCGDAPLGEHVILRLGQLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPB5</accession>
    <name>A0ABR3VPB5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="65"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="464" mass="48638" checksum="E34EAB17339C7841" modified="2025-10-08" version="1">MEKDPEKTADASESDRTETATTDSETTTTSTPAAPVRPDTTSATGGGQPSPSPPTHDNVPDGGLMAWLQVLGSAAVLVNTWGVINTFGVFQAYYESSLLSSHSASEISWIGSAQAALLFLVGVIAGPLYDAGYFRHLLAGGLLLTVLGQFMTSLCKLYWQVMLAQGVAMGVGMGMTFLPSAAILGQYFSRHRALALGLSSVGSPVAGTVFPIIFSRVEEKAGFGWATRAIAFILLGLSAIPLAFMRTRVPPTPRKGKGALGMIDATAFRDTPYVLFVAGGFFAFLTLYVGFFYVTLHATSHGIASARGFAPYLVTLLNAGSIVGRIVPNALADRYGSLNLILACTMGSMVLVFGWLGVRDLAGAIVFVVLYGAFSGGVVSLTPSVIVSLSPDMGRVGARMGLSFVVAGIAILIGTPIAGAILGSTEDPRWTGTILYSAFGLLAATLLYFASRLLLFKKKGDWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPH2</accession>
    <name>A0ABR3VPH2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
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    </dbReference>
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        <property type="entry name" value="Ketoacyl-synt_C"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="674" mass="73182" checksum="0B4653220680937E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPH9</accession>
    <name>A0ABR3VPH9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31232" checksum="E9257563F6B81571" modified="2025-10-08" version="1">MEDGAVSKLIPPTPPILRSTTADPEPRNTKNLASRLGVDLLSASIAAGLVAPFITIIDRSIIENASGRRPLSHSLRTSLTTLLRHPAQTLLSRPCALVFTVYAATFLTANTLDTAVATARALPVTHVDAGVVKFAASSAANIAACAYKDQAFARLFGAGVVSRPVRWSSYVMFAARDCMTVFASFNVPPVLGPVLTGLMDGDGEGGSVSVVSGQTLAQFVAPAAVQPVSTLSHLWGLDLYNHPAGATGASGWRERWGRVRRSWAVSTAARVCRIVPAFGLGGVVNSKVRQELMGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPM7</accession>
    <name>A0ABR3VPM7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1020" mass="110758" checksum="8311D0B2D1A1F7A5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPT0</accession>
    <name>A0ABR3VPT0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="196" mass="21520" checksum="ACD1526C79C6AA1A" modified="2025-10-08" version="1">MLLQRHRMHTQPSSKPLLLPDLVNNPGRHDGACSIHRGWSRFVSPLDETSRFPSAIGRRAAAGSGVTGSRRGKLLLLQPLQLLQRQAALFQLVCLLLAPLFPTLVNWLPSQTLRCVLVAYLLNLLVLSRRLEDGADIIREAQLFQGLDDVVAGDGLLGLLLRDLVGLGADERDELDATLYEYVARFLGEGDPGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ32</accession>
    <name>A0ABR3VQ32_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="205"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="401" mass="45259" checksum="9EDB2CB5B63A5B54" modified="2025-10-08" version="1">MAANATAISDLPPLPAIDLQPMPDLLPFISDFWLGLIAPHIAYWVLSMIFHLIDVYDLFPQYRLHTPEEITQRNLASRWEVARDVIIEQIIQIATSAFLSLTEARQMTGMEDHDVAVWATRVRLAQRALPALLGTLGLNAAAISKNMAASYPLLAGALAGGHYPFLTTTLEGATGSIPVPAFAPWELLVAKAIYWVIIPGFQIWLAVCFLDTWQYFWHRAMHMNKWMYTHWHARHHRLYVPYAYGALYNHPVEGFVLDTVGAGLAYKVTMLSPRMGLVFWTFSMCKTVDDHCGYALPWDPLQRLTSNNAAYHDIHHQSWGIKTNFSQPFFTVWDRFLGTMYKGDVKLKYAQTRASAAAKDARKKGGEVSVNDMAASLARSKEESEAKGEVRNRGEKMMDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ92</accession>
    <name>A0ABR3VQ92_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-alpha-glucanotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="3">
        <location>
            <begin position="145"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="4">
        <location>
            <begin position="750"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1565" mass="176532" checksum="EF26CE4CAFAD2182" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQB4</accession>
    <name>A0ABR3VQB4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="189" mass="21482" checksum="C2890706081ABA4B" modified="2025-10-08" version="1">MAATKEPNADSEVHKTSLPGELQYIQYQHSLEAQYLPAIRSLISKDLSEPYSIYVYRYFLCQWGHLCYMALNPTDSSLIGVVICKLEMHSSHSTPTLRGYIAMLAVSSQYRGHGIATKLVRMAIDAMAERNADEIVLETEETNIPAMRLYERLGFLRSKKLHRYYLNGNSAYRLVLPLKAVDESAEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQF4</accession>
    <name>A0ABR3VQF4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-14 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="324"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47820" checksum="946C97FBDD8A9DE7" modified="2025-10-08" version="1">MKFGHAFQEALAANSYPAHWVEKAVPYRQLKKILGKVREELIKNGYSPDTLQQLLQQHNAEYRLETDSSHLLRPKLIVRPGASRSLPPSPTTSEFQADGAVVLPDPASNSGNGTPGEDEWVKIPLNSDVRFFTLLQTDVEELDTLQDKERQSMTTQIHILGTEIAGVARPRKGLVRLSKSDLYRWREIFELYLAAEVFFSTTEADGGLRKSEAARKQLVWFQEEVNKRQLPQRFKIESSAVAYSQFLALNATLLQNLQFQELNQTAVTKIIKKFDKRTSLGVKSTFPKLMYSAQVISGSISRDICAQLAREVVNLVPQVVDFSCTICLSICWLPIRLDCSHLFCIRCMITMQNQNKRFCPLCRAEVVQKADESNIDEALVRYLEKWFPKETKEKQTLNELERRRDLFGDVYVNEHPPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQG3</accession>
    <name>A0ABR3VQG3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="254" mass="29053" checksum="8E925C098F51F731" modified="2025-10-08" version="1">MVDPFEVRMRFTSQLRGLNASVMSAQKAAQYALKHRDMAEDLHSCILEQLETNNMNTRANIMYFIEHFLDMAPRGGQDDYVRMMQRDIIRVVDAVVPDDGSGAANVKVVRKVLHALQSKSFLDAQTVSQIDEVLKERDASAQDVTMSSPPPPSADGGESEPPTSQQHRGSSRRTGRNQPPRPDKKQIEQRIEEDRERHKRQREHVWAVPPGEDAEMERLWEETSDLGEDDVRMGEEEWAEWRAEFEARSKRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR40</accession>
    <name>A0ABR3VR40_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor rrn3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="81628" checksum="A1A40FBDD7863A9B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRD7</accession>
    <name>A0ABR3VRD7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="183" mass="20651" checksum="632DEE4CA8C289B7" modified="2025-10-08" version="1">MAGLFKKVYDWLLRTFWATEMDVTMIGLQNAGKTSLLRVLSGGEFAIDSIPTVGFNMKRVQRGHVTLKCWDLGGQPRFRPMWERYCRGVNAIVFIVDIADLDLLPVARDELHLLMSQPTLDGIPLLVLGNKSDLPNRITVDELIDVLDLKDIANREVSCYGISAKEETNLEAVVQWLMKFAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRJ7</accession>
    <name>A0ABR3VRJ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="131"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="579" mass="64008" checksum="981D350E958ED414" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2D7</accession>
    <name>A0ABR3V2D7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000517">
        <property type="protein sequence ID" value="KAL1835881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="58897" checksum="6575BE6A47F97934" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2S0</accession>
    <name>A0ABR3V2S0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cut9 interacting protein Scn1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000481">
        <property type="protein sequence ID" value="KAL1836016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="47890" checksum="3EFF891381DB3A6D" modified="2025-10-08" version="1">MCGGDAIPSGQTPAAPTSSDFPWHLSLADAHCHPTDTMASIASIPSMRARVLTIMATRSQDQDLVASVASKHAIRDRAALASGPAEGGTDRVVPAFGWHPWFSYQLYDDAAAVERGPTTTTEELKAKHYGAVLSPAPDDAFVAGLPDPVPLSQFLADTRRRVLDAGVAMIGEVGLDKAFRLPWPWGVSQGGAGQEESKKGEQQPQQQATPEITPGGREGRMLSPHHVRMPHQVRVLEAQLRLAGELGVPVSVHGVQAHGVLFDVLAGLWKGYEKEVVSRRKQKLVAPGAEDFSSSDEDEEDDDGFELSDGEGGFGQPKDWPRIAPVAGRRYTPKPFPPRVCLHSFSGSPQTLKQYVHPAVPAKVFFSFSSAINLSTAGGAGRFGDVVRACPDDRVLVESDLHCAGDAMDSVLEDITRRVCEIKGWSLEEGVARIRKNYEEFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2V2</accession>
    <name>A0ABR3V2V2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000464">
        <property type="protein sequence ID" value="KAL1836104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28429" checksum="E9EE596F05CCC3E2" modified="2025-10-08" version="1">MSTPRVFIVRHGETEWSLSGRHTSTTDIPLTANGERRVLATGRALVGHDRLIVPSKLAHVYVSPRRRAQRTLELLNLAFHSSLPWTPHGTTTTEPGEGLPCPAAIEVTEDIREWDYGDYEGITSREICALRESQGLGSDWNIWRDGCVGGESPADVAERLDRLIKEIREKWHAPVMNKEKVDGEEPVRGDVLIVAHGHILRAFAQRWTGQSFDSGPSFLMEAGGVGTLSYEHHNINEPAILLGGAFVVDIPEDDTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V387</accession>
    <name>A0ABR3V387_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000449">
        <property type="protein sequence ID" value="KAL1836195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="344" mass="36244" checksum="3A757DEE76E30E7A" modified="2025-10-08" version="1">MVAVASLSRVDPLCLFNSCVEQVAGLLDSSPVVYYEACTLAFGAPSTTTYTVDSLVYTATKTEMYTDIIITLSTTTDVSTTTARSSTTISDVATVTSTVVVTETQTRTVTPAAAAKKRTAPVKRSRRGCAGHSPVIPSPSTDATASSTSTEVISATASPIPSNCANLEEFSSACQCITAVSDVYVTVTVTEATSTGTITANTESTAIPSTSTVVEIVVDTTTVTERSTITIFTRTTTEVTTSTTTAIVTATDSPNIEGWWVVVSPPKWAGKYLTQHNQGNTFLSDTPNNQIGIPRGGGQPFSVGDRFKHKMFVHRWLTSNNLSPLLSKMQGADGDLPMNCSPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3G0</accession>
    <name>A0ABR3V3G0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acriflavine sensitivity control protein acr-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000440">
        <property type="protein sequence ID" value="KAL1836256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="44205" checksum="D32D82399136E4F4" modified="2025-10-08" version="1">MTIFPSPTDPLLAHLNRESRHYVYHFSTAVCQGLVSFDQPDHNPFRAILPLAARFDFLEAILVATGAMHLAALRARDSGLGGPELVDALVAKDRAICLLRAAVEDVTPMTQPVVLAATVFLVNLDLIDSGRGAWQPHMAAAGVLMPSLLSSHLAASDSSLAACFNAIAADCLTYRVLGSAINGVSLNLSWSAAADQAKFLSVLRRAEAHTYHCCPPEILNIILAASDLCDDRTTPDRVEQAQSLLLHGRSFDVVSWVRNIRGLSDRDDLDVRVSVASAHRAAACLYVLLAVPEAAEGPSLPPLTVDGLVREVLKHLAAVPVNHVHLKGTIWPTFVAGAQADNPAQRAWCAGRMRALGSLNPWACPWGYIRTAARVMEQLWEARDTAAAGGMKPNWLMEAKRMRDKCLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3G3</accession>
    <name>A0ABR3V3G3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000460">
        <property type="protein sequence ID" value="KAL1836132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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    </dbReference>
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        <property type="entry name" value="F-box domain"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="525" mass="56929" checksum="AE1CC8AE1662421C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4C6</accession>
    <name>A0ABR3V4C6_HUMIN</name>
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        <recommendedName>
            <fullName evidence="16">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_5553</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000462">
        <property type="protein sequence ID" value="KAL1836118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
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        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="195"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="398"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="777"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1836118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="98993" checksum="61F3D2F985DA2FAB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4F1</accession>
    <name>A0ABR3V4F1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor ISY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000458">
        <property type="protein sequence ID" value="KAL1836148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28775" checksum="B7D90B628B19982B" modified="2025-10-08" version="1">MARNSEKAQSMLFRFREAQAAELGIIDAGRTRRPRNITEQDSIPACEKWRGQVLKEISRKVSRIQDPALSDFQIRDLNDEINKLMREKHMWEVQIRNLGGPNYMRAGPGGGGKMYDEAGREIPGVGGKGYKYFGRARELPGVKELFEAAAKARQEQQEEKPLEERTDLRRQVDAAYYGYAPGEEDEELLEYERTRERMAFEALAKAGPAETPPGWEALPGDAGDGRGWDLPALEEVQQELIDRRRRRLLDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4R6</accession>
    <name>A0ABR3V4R6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000376">
        <property type="protein sequence ID" value="KAL1836706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="323" mass="35532" checksum="88E9B68297273FE5" modified="2025-10-08" version="1">MSSNKTVLVTGATGLLGRQVAKAFAFHDWTVKGTGFSRADGKSILKVDLSDAGEVERVLDEVKPQVIVHCAANRSPESVDSDPAGARALNIEASRSLALASAARGILLIYISTDYVFPGRPGEAPYEADAEPAPTNLYGQTKLDGEKAVLGVFKEQGKSELGVVLRVPVLYGEVDKEKGNKESAVNILMDTVLKAAEKGAEGKVKMDHWAVRYPTNTEDVARVCYDIAIRYLNETDKPSLPRILQFSSEDRYTKYEICQIFAEIMGVPMDRIEPNSQGNDPNAAVQRPYDCHLSTRALQDLGIDVSTQDFVGWWRREVRAFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4T7</accession>
    <name>A0ABR3V4T7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000369">
        <property type="protein sequence ID" value="KAL1836765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="447"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="733" mass="83426" checksum="2092B8F734E511EC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Z3</accession>
    <name>A0ABR3V4Z3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_4614</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000361">
        <property type="protein sequence ID" value="KAL1836833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1836833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="349" mass="38501" checksum="BB6385573BA98610" modified="2025-10-08" version="1">MGFLAGFVRLPSLSNLLTHKTNTKALQTGGVTLTLSLTYLALLTHTRNREAQSSILRSQISTLDALVPPPAGRRNATVPLPDGTYRPRDSLEQYRPEAVPSPSDSSTPSRKERQPFLETAKTRWNSEILSAVHWAQTKDWARVREDAEQSLARLLGIELSRDHPVPASPSEQPAHHHHHHDPLGFSSSSSPENQPREPPPQPRRGKVSQVLHQTRDTTLAVAHAMRDEAKEIVAEAREVAEEAVQEAKEAMAHRKDAAVAATKKGEEKVTKKTHEVAGKAKAAVHLAEEKAEGKMEAGLSGLSDVERALAERYDAARREEKMKKSAEEVLKERYIPMEGGKSKGEDKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V536</accession>
    <name>A0ABR3V536_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000354">
        <property type="protein sequence ID" value="KAL1836887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="126"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="456"/>
            <end position="551"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1198"/>
        </location>
    </feature>
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        <location>
            <begin position="1230"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1044"/>
        </location>
    </feature>
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        <location>
            <begin position="1045"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1078"/>
        </location>
    </feature>
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        <location>
            <begin position="1089"/>
            <end position="1098"/>
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        <location>
            <begin position="1155"/>
            <end position="1164"/>
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            <end position="1257"/>
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        <location>
            <begin position="1275"/>
            <end position="1286"/>
        </location>
    </feature>
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        <location>
            <begin position="1288"/>
            <end position="1302"/>
        </location>
    </feature>
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        <location>
            <begin position="1303"/>
            <end position="1331"/>
        </location>
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        <location>
            <begin position="1349"/>
            <end position="1368"/>
        </location>
    </feature>
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        <location>
            <begin position="1376"/>
            <end position="1385"/>
        </location>
    </feature>
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        <location>
            <begin position="1388"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1405" mass="152563" checksum="34453E0F9D5B8C77" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5C9</accession>
    <name>A0ABR3V5C9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000343">
        <property type="protein sequence ID" value="KAL1836974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="233"/>
        </location>
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        <location>
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            <end position="373"/>
        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="377"/>
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        </location>
    </feature>
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        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1836974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="72654" checksum="45A2E82D7216DCCB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5F1</accession>
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        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
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        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000341">
        <property type="protein sequence ID" value="KAL1836992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="723"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1126" mass="123726" checksum="D7345FF3A791E349" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5J9</accession>
    <name>A0ABR3V5J9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000351">
        <property type="protein sequence ID" value="KAL1836905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00913">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114238" checksum="24D93E9FCD4D5A0C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V5P0_HUMIN</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000335">
        <property type="protein sequence ID" value="KAL1837050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="324" mass="34393" checksum="85C1CD887C680507" modified="2025-10-08" version="1">MGDEAEKRDIKGKGKGKDPDSGTASIPDAGASDGKKARETLSQMAQSAASFLMSGPPGPGLPGSSEKGESSRTGETLARAAESSVHLRTNVSSGQTSYRSGHAEEHIAREEASFAAFLDSNDAPTLSEPSDPSAVFQLPLASQHTTTREVAGTWEPVPLSVAEQQARDGTDVVALLSSDDNLDDVFTQSNEPSASMDDVAALRRALFGDGMASEDVAWDNVLNFIPEFLQGHQGLNPTPRGDDLARYLGTADPQGAWDAWISQWSRVLTSYQDEVWGDLGELVVEARAEVERIKAAKPGEKPPEPKALLRLRAILGHLRGGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5X5</accession>
    <name>A0ABR3V5X5_HUMIN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4622</name>
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    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000362">
        <property type="protein sequence ID" value="KAL1836821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="239" mass="26512" checksum="CAEE83E92905300A" modified="2025-10-08" version="1">MENLSEEQTTLIRHWSMYGQRGVTPKHRVTPEEWRHFPFSKPETTSWHVPIAPDQLPLLLLGFKPRQSNTSPGGGLFWRGVLQAGDTIKMHIFHSVSQNPDMHASEDKWFVYSEGPDHAQEVRLHMHRSWSGVKSMELRIDAGFDGRGSDGKGPRITAITWETDPEKAGKDISAATAKDVVREVCSWVLNVDLGPGEGALSSSAEVVLPSSNDMMRPTADGLSSAMVPLPEGTTAYRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Y3</accession>
    <name>A0ABR3V5Y3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000322">
        <property type="protein sequence ID" value="KAL1837164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="817" mass="90859" checksum="C321C715A6D0ED86" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V615</accession>
    <name>A0ABR3V615_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="3">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000369">
        <property type="protein sequence ID" value="KAL1836763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18817">
        <property type="entry name" value="GH43f_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045640873" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="9">
        <location>
            <begin position="368"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="474" mass="51481" checksum="76F417DCBA2F0A79" modified="2025-10-08" version="1">MRISGLVAALTAVLSAGLAVASPAVNYVNSLIQQRADPHITKHTDGWYYFTATVPEFDRIILRRAQTIQGLASAAETVIWRRKWSGVGSGQVWAPELHYIDGRWYIHVALGVSGQWRIRAFVLEGVGANPLTASWTEKGIIQTNWDTFSLDATTFTANGTRYLVWAQQDPSRNGENSSLFIAALQNPWTIRRPAVAISHPDLAWERIGYKVNEGPAVIQRNGRIFMTYSASATDHNYCMGLLTADANSNLLDPRSWRKAQQPIFASNAATNQWGPGHNSFTVSEDGLSDIMVYHDRGYRDINGDPLNDPNRRTRVQKLYWKADGTPDFGIPVPEGPTPVRLRVAASPNGNTYVRFYTGGAGNLTGTAALPDTQFKLVSPGLAGGDTVSLESTSNPGMYARRISGASAVQFERDSAAARAAASFRRVPGLTDAAGAVSFEASDAPGQYLRLEGSGRLAVAPVAEGTEGRSTFYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V689</accession>
    <name>A0ABR3V689_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000311">
        <property type="protein sequence ID" value="KAL1837279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="58"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="239"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="401" mass="45533" checksum="93607B9B35A2B5CB" modified="2025-10-08" version="1">MADGPGLDRKADEKIQFTTSKEVTVHPTFESMSLKESLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISMLQVIDTAVRETQALVLSPTRELATQIQSVVMALGDYMNVQCHACIGGTNVGEDIRKLDYGQHIVSGTPGRVADMIRRRHLRTRHIKMLVLDEADELLNQGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRILVKRDELTLEGLKQYFIAVEKEDWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGEMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTSEDVRILRDIELYYSTQIDEMPMNVADLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6I2</accession>
    <name>A0ABR3V6I2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000302">
        <property type="protein sequence ID" value="KAL1837364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="993"/>
        </location>
    </feature>
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            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
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            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="104"/>
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    </feature>
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            <begin position="127"/>
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    </feature>
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            <begin position="157"/>
            <end position="170"/>
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    </feature>
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            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
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            <begin position="972"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1010" mass="110030" checksum="42DDAA5BD7AB32C0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V6T9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_3778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000294">
        <property type="protein sequence ID" value="KAL1837441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="398"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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            <end position="116"/>
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    </feature>
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            <begin position="135"/>
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    </feature>
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        </location>
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        <location>
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            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1837441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43040" checksum="620DD8941D0E0CEB" modified="2025-10-08" version="1">MAGRPPSNRSSQPAAAAPPRQNEYFVPRDGIDREVIQSDICRYLGNDALVRPGTYETDTGEAMIEDLKADSARWQAERRAAASRNTVSPVGGSRDPPRDQNYNTWKARQEQQDRYQAEPYGGAMDVDSYPPVSGAVPNPAYPAAQAYPGQAPVGYHQGPYPPPAQPHYQPPPPNYGYPSNPQQPQYSPQPQNGDRYQTMPPPQAPIPAGYGQDPYVRGSDYQAGGYAAAAPNRGAPPMPHVSGAPPRTYPSPAPPGPIYGNDRDQYGGYHPQAGGPPVQPYPTDALYGRGAYPTATTAPNQEASSDDLGSPAGAPQRPPFGSAPDPAYDDPQQAGIPKPTSPAAASSSPIPPPGAPPARRERDRDSDSELPRDQGYRDYKSRRTDVDREDRDRNRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V708</accession>
    <name>A0ABR3V708_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000314">
        <property type="protein sequence ID" value="KAL1837251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1837251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="526" mass="56738" checksum="5DE560FE822B8D16" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V712</accession>
    <name>A0ABR3V712_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein EsdC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000282">
        <property type="protein sequence ID" value="KAL1837568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30450" checksum="FA6572ADFA046EC2" modified="2025-10-08" version="1">MSAIQLSFSLRVSSGVKTVHLLGSWDNYSNQLPLSKDKSSSKGTWKGTFRFQQTLLQPGQRYWYYYIIDGYHIAHNPSEDSTVEPTTGRTLNILDVPKSSSSSKSSSRKSTSSSKSRASASGDIPKGRPLSVSQIKSPKPVVPNAARNILTKDFDEDELSSRFAATGIYDDDYYYDDADGIITDFGAIPGSPASSVGSSLSYNSDSSGASRSSGYSTPASDCSSNCTCERYGITRKGERVRLDCGGSRCSYDDSSSSCSSSEDEPEYVARSSRRNGIVVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V772</accession>
    <name>A0ABR3V772_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000280">
        <property type="protein sequence ID" value="KAL1837590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="169"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="353" mass="39847" checksum="D27CB2803C60F299" modified="2025-10-08" version="1">MAPSLPIIDYAKIIGAEVSDSPEARKASEEEKRNLFKAFVDVGFVYLANHSIPIFEQNKLFEHAKRFFALPESEKAKVETGESKGFHGWFSPARTSGNKDTSDLKEAFDIGKENDPTRPNQWPEGWTEFRDDMNSFFEKCHQVHLVLLRALAQQVGIDENFFEPHVNARDHFFRVIYYPETTRAGLRNRLRASAHTDYGTLTLLFNDNSGGLQVRRTDGTYVEAPPIPGYAIINVGDLLARWFNDQLLSTEHRVVEPEPRPDENGNIPDVIPARYAIAWFGHPNRDALVEPLDACCTEATPKKYGPVYAGQHVVERLAYLHKKGQNTATWTDDMQRDAPGNVVAVPVVPTKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V799</accession>
    <name>A0ABR3V799_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000293">
        <property type="protein sequence ID" value="KAL1837452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046145741" evidence="2">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="271" mass="29676" checksum="F781D2B61AEDDFD7" modified="2025-10-08" version="1">MSRPRPASVGALVLSPISLLSALPAASPCQFSSLGMHPVMGPSVKVDAAPESWEDRNPTREHPTLSRRRLLGLSAPASISSNVHRRSLKQSGFLSSGSFYSEEETAHSSSHQPSTPATPWTNSKQQQQQPQQRPPSLGLLKPSTSPFFRKEYHITLQCPIHPTFCPKLDRINKREGSLWAYKDPNFVGADGVHKPWVVTVNVCDLANSLSQGESTIERFIRDNSPDGTTPGGPIAPWDAMAFLRELEEVNRRTGLRVLVGSVGEGVEWPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7I3</accession>
    <name>A0ABR3V7I3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_3440</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="JAZGSY010000266">
        <property type="protein sequence ID" value="KAL1837748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046540089" description="Mannosyl-oligosaccharide glucosidase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="16">
        <location>
            <begin position="37"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="294"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1837748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="809" mass="91099" checksum="3FA7FC4BCDE0953E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7J1</accession>
    <name>A0ABR3V7J1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000265">
        <property type="protein sequence ID" value="KAL1837759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41957" checksum="871562E5E7CB9571" modified="2025-10-08" version="1">MCKIRTVHYTLHDHRRLISMQLFSSPDEDVLVGGSKSRVCNCPPDFASEIPEHADNVRRLRGLSPCSSHHPCCLCHRNVTLCQAYLDKHGLKEHPRTPEGGWTDLDECPNTIWLDHFHKIGALFPEGSFGHLDEDDWHYIPTFPADELFYSDDITQCFPANPDSSALQVDRVIACNGAMSMHTSKLKLKDAIETADNFLDAFENYLTAFAVNQSHFRNKAPLNDDQLHHLMWWCKKSKDTVSQVESAELQTALLYVGVMKYASSTLEALQRLPAPGESIRSRDGRCSLSREQLDHGKLTPREAIAACDGPLKQRDALQTRLMNCILRVLRLRAGRQLSSPPRTSQVLPGHRVMKRSAGRQMAARRPRRNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8E7</accession>
    <name>A0ABR3V8E7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3072</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000239">
        <property type="protein sequence ID" value="KAL1838080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046741405" description="Mannosyltransferase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1838080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="651" mass="74679" checksum="AC17747549A1C543" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8R1</accession>
    <name>A0ABR3V8R1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_2996</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="JAZGSY010000235">
        <property type="protein sequence ID" value="KAL1838145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1838145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="342" mass="37725" checksum="C02C290827473C06" modified="2025-10-08" version="1">MSMNGNTYTNTPQRPPLNLGPVRAPSSPDDETPRSTDSATSTSFFSSPASSPATSSPTFSPVVWSRQDSTASTLVPTPTTTTTRKPYPVSQRKVNAHSHCGRHSDEFLFHGWRDLFRGVTTVLRQVADAMAKSNGGFGPKKAYLVLYNTASAIAWATILGRVLVVAQWRGAPFVPLVVDNFARITQTFAIMEVLHALTGVVPAPFFTTALQVASRLFLVWAVCFPFPHLNTSAWYSSMLCAWSLTEVIRYSYFALRQFNCVPSWLHWLRYSAFSVLYPIGISSELAMTLRAIAGPASLLAAWYPWALFAVVLSYIPGSVILYTHMLKQRRKYLGAGADKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V974</accession>
    <name>A0ABR3V974_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Formate dehydrogenase</fullName>
            <shortName evidence="9">FDH</shortName>
            <ecNumber evidence="3 9">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_2861</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="3 9"/>
    <dbReference type="EMBL" id="JAZGSY010000227">
        <property type="protein sequence ID" value="KAL1838252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="14">
        <location>
            <begin position="608"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="15">
        <location>
            <begin position="861"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="1210"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="13">
        <location>
            <begin position="1306"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="728"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="1351"/>
            <end position="1352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1372"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="1407"/>
            <end position="1411"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1433"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1459"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="1488"/>
            <end position="1491"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1534"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="1435"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1838252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1541" mass="167819" checksum="0E79DD6CA84776C3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V998</accession>
    <name>A0ABR3V998_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000216">
        <property type="protein sequence ID" value="KAL1838409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="53" mass="6083" checksum="6FA5DAC60E6459DB" modified="2025-10-08" version="1">MTEEERKQFYDNIWNLVAVSSEVAELEAAQAIVGLQFEVVQARRNALDKELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Y4</accession>
    <name>A0ABR3V9Y4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="134" mass="14272" checksum="6EEF7A0D90403C0F" modified="2025-10-08" version="1">MFVTRVLRQAAAHAERTPSIRFLGKRTFPASVDPTPKPHPASPTGTLPASWTSASAHPTFSVYRDHAQQFGPLRKTIKANSAGVGGMAGSELGPVSPPQGVFFDRNDLPPRFHRQPLTAAEIEAIETGGAALYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA64</accession>
    <name>A0ABR3VA64_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2262</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="220" mass="23371" checksum="B0370CF2DEFCC434" modified="2025-10-08" version="1">MMTAAPAMSHPGQGIPMQAPPPPVVGAPVGQPVPQPVAPAGAPAEAQVTDDGRKAKRPLSTSKRAAQNRAAQRAFRQRKEHYIKQLEQKVRDAEQLEANYKALQAEHYSLRDYTLRLQALLIDTQGECPAPPPGINLHQQPPNAQPADPGAMGQQPPPDSAAAVNPLEVAAQAVAGLNRSASEHYGQVRSTADEDARTAQELTRQLQAEGSTDGLPTPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA70</accession>
    <name>A0ABR3VA70_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000200">
        <property type="protein sequence ID" value="KAL1838670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="183" mass="19724" checksum="FDAF96B196DA1E9F" modified="2025-10-08" version="1">MGSDDMDVDEPVRPSGETNNSLYANDVSAAKLAAMQTHTKATAVRSIEGWIIIVTNVHEEADEEALHDKFGEFGEIRNVHLNLDRRTGYVKGYALIEYTTLEEARSAIDGAHNTDLLGQTVQVDFAFVRPPPGKGSGARTGGGGGARGSNRGARSGRSRSRSPGAGGGRDRDRDRDRDRDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA98</accession>
    <name>A0ABR3VA98_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000198">
        <property type="protein sequence ID" value="KAL1838700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="311" mass="33466" checksum="D92436B9662F3A9E" modified="2025-10-08" version="1">MTIDIPSLPTTFDRPVHIAVIGGTGLSSLPGYHPVAALNPSTPWGLPSSPILILEHSGVPVAFLARHGLHHQLAPHEVPARANIAALRSIGVRSVIAFSAVGSLREEIKPMDFVVPDQIIDRTKGLRPFTFFEGGVVGHVGFADPFDAGLAAVVQKCAAAMRGDGVTLHKGGVVVCIEGPQFSTRAESNMYRLLGGSVINMSALPEAKLAREAELAYQMICMATDYDCWHDSGDVDVAMVMGYMRANSENARHLVGAVLDELCKQENGDLVLAKHWEGSAQGAVKFMTKPEGRDPEAMKRIEYLFPGFWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAJ2</accession>
    <name>A0ABR3VAJ2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2168</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000190">
        <property type="protein sequence ID" value="KAL1838845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16792">
        <property type="entry name" value="SP-RING_Siz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031141">
        <property type="entry name" value="SIZ1/2_SP-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="183"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="386" mass="42159" checksum="1FC3212FE2C34908" modified="2025-10-08" version="1">MTAYPARPLAQGLNPPTISFKSSPFYEPMYQVGDVRTLEVMTAHRNTERISVKVSDHPPLQLCATDRTMRVMVMCAASNVGVQDIAFPYQCELKVNGGDIKANLRGLKNKPGSTRPVDITDALRLRPQSYPNNVELTYALTQKRFYLTLVVCKTVTIETLVSQIQKKIRKESVVAEITKKASDPDEVVATSENLSLKCPLTYMRLKLPCRGISCNHIQCFDATSYLQLQEQGPQWLCPICSKSAPFDQLAIDEYVRDILTKTSDCVEQVTIEPDGKWSVPGANKHATPSHETTSLDDDIVISEVTRTNRGSSTVGTAPGRASTSTPHLATPTSVASTPSAAAPPSRTSTKRPAPEVIDLTLSDSDDEPARPVKRANYGQTTGSGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAK2</accession>
    <name>A0ABR3VAK2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000195">
        <property type="protein sequence ID" value="KAL1838746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="24"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="546" mass="59767" checksum="10786EFF5383C610" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAL3</accession>
    <name>A0ABR3VAL3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000211">
        <property type="protein sequence ID" value="KAL1838481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="270" mass="29435" checksum="86C2E7A3C3B78696" modified="2025-10-08" version="1">MDGAPGVKLKRPIPRYPDHHTRPRQPGIRHTMSLHESIISKLLYSAQRFTDNVIPPETRERVATQTRTFAEQRPFLLTFLTLQVLFAAFPLLLLITSLLLSLAFFAGVTLLALAFVSTAVCLTLFVTAVFFVLPVFVVSSTAATFAWVAAVGAYVAARWIWNSYVSLRVDDGGAPWVEGMGTGEKNGEGKKGTDVGIYAGDGGVDGGRWGGNKAYEGEGAPFFSRPLRKTKLEDGGAREDGVGHGLISDEQVKQEHYSYLTLNGDNTLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAN0</accession>
    <name>A0ABR3VAN0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000199">
        <property type="protein sequence ID" value="KAL1838690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="569" mass="61736" checksum="020CAD234C65F36D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAU7</accession>
    <name>A0ABR3VAU7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000190">
        <property type="protein sequence ID" value="KAL1838849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="388" mass="42379" checksum="34993202DB3B2E4A" modified="2025-10-08" version="1">MEPPQHVSQATSPATQSPAIMSAPRPHPQAILDLVAYNRADFELPVVSVHRSQHDAVRSSLFRPLGQAADFDLGTLSRLPFEILSLISLELDAASALRFSHVNRSAREVLAAVREFRELRDHALEAFCVLLRTGLGQHVTALDLHKALTTERCELCGVFGGFVFLPTAARVCMTCVASAPETRVTHLSRVADGAGVPSNELVRGGNLPVLHTLPDSRKRIVAVRPHALNALQARGMSEEETEAVVDRWSDSLTLRFQAATALPFLDRYGRQAQPGMSCKGCQIAFEKSFSDDHLEMRDRFYSKQEFLQHVEECEPAQKLLAAAQDGSGIVEEPRFGTCVTVTSPAGTDSPSADPTAQGRTLIGCFTELLSASRRLRTPMGALNRHPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAV0</accession>
    <name>A0ABR3VAV0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000209">
        <property type="protein sequence ID" value="KAL1838516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="542"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="963"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1036" mass="109901" checksum="4B045883F0AB4D4A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB86</accession>
    <name>A0ABR3VB86_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chorismate synthase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000182">
        <property type="protein sequence ID" value="KAL1838972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40678" checksum="CDB2A0D7BB603359" modified="2025-10-08" version="1">MAIPWGSIKSAVIFFGPILLPKAIAWYREAFSAPQRHGLKIIPLSAPLRRTVALLIAVAVVFLLLCLPVFSPENIFTLTQSRLQIPADVLFTRLSSLRPNRALTDSDLSLRARFTSLESRLLYLQFGPSVLASCPFCTSDDPRSYLYYALPDILTPNLFNLVIIALATSSLLTMDNKPTSRAVAPRFRTPFTLASVVLATFDLYRVATYNHTANARALRLNEIDFFFWSARRSRYLLLAVVDITLAFVVHMSGTNRAFVAPPPAAERVEAIARQLAGTKGRVNAAGVVKNTVLRDEELRGRSVTYWAHEVRLMREMMEEREVVEGVNDALQNRIDIAGIERDAEAYAKAMLAPLVGEGGEGKVEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBK6</accession>
    <name>A0ABR3VBK6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000170">
        <property type="protein sequence ID" value="KAL1839195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="364" mass="40032" checksum="50D793B5DBA6C9DD" modified="2025-10-08" version="1">MVKETKLYDQLNISPTATQDEIKKAYRKAALRWHPDKNKDNPEAAEKFKEVSQAYEILSDPEKRKIYDQFGLEFLLRGGVPPPEGAGAGPNPFASAGGGGGMPEAFAQFFTNVGGGGAGPRGFSYGMNFTKPEDLFANTFRDGDIFEDILYNAARSSASSAPGTGSSRRSMRGSFGESMRSQRAATPEVTTVERPLPLSLEDLFHGVTKKMKIKRKMFDDNNKRTTSDAILEVPIKPGLKKGSKIRFKGVGDQEEGGQQDLVFIVEEKPHPLFVRDGDDIIHTVDLDLKEALTGWQRTITTIDGKNLQLDKAGPTQPGSSESYPGLGMPISKKPGQRGNFIVKYNVKFPMTLTPTQKQKLREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBP6</accession>
    <name>A0ABR3VBP6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000174">
        <property type="protein sequence ID" value="KAL1839119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF11">
        <property type="entry name" value="WSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046734888" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="498"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="625" mass="66816" checksum="5874BCBF9B224BDA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC18</accession>
    <name>A0ABR3VC18_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000167">
        <property type="protein sequence ID" value="KAL1839257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="387"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="748" mass="80558" checksum="DEDF04F878E1CA15" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC32</accession>
    <name>A0ABR3VC32_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_1921</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000178">
        <property type="protein sequence ID" value="KAL1839057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="299"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="963"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1315"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="963"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1023"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1115"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1158"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1204"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1315"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1390"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1839057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1411" mass="152846" checksum="F6360336C0819787" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCP4</accession>
    <name>A0ABR3VCP4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">VTJ49DRAFT_1321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000148">
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        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
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        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
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        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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            <end position="85"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAL1839618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="449" mass="51351" checksum="D2C740B62ED58C06" modified="2025-10-08" version="1">MEVDVHAVEDTATRYSYLFPIGYSNSSECGYCHRTRSAFYQKLVDRCWRRSGSLLYRPNQRHSCCPHYTLRLDSTEFKPSKAQRQAINRFNRHIIGPTYPREAARLHPRTRAEARRRHNVFDLVERVHEPEAGVLKTPPQPDHVFAVTLEPDTFTEEKYAIFENYQRIVHREPPDKISRDGFRRFLCDSPLVRGSVAGPDGRRRPVGSFHQCYRIDGRLVAVGVLDLLPDCVSAVYFLYHESIHWLNPGKLGALREIALAQEAGYRWWYPGYYVHGCAKMRYKTEYKPQQVLDPEDLSWYPLDEQALALFDKSHYVCFSRAGQSQHQQQREVLSQTTGPPGSAANGHDTATTNSDSEAVEEDEEDAFLLASNMPGIPALAEMEALDMDSLVLRSDFSDNLIIASHLVIWDTERVGQFGTLKSRIAELVAAVGPDLMGEFCVDFRKRRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD62</accession>
    <name>A0ABR3VD62_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000172">
        <property type="protein sequence ID" value="KAL1839163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="465" mass="50146" checksum="9F91B26A565CFB3C" modified="2025-10-08" version="1">MPYPFVLPTTSSFSFSSAFTCESHPSLPLQASTHRGVVRDTLKKHKRLPPASQGPDLPNVASALQTYIPYLLAIEAGLSPRTLGAGGHVTVTQTAPPQIEWRPTLASSFLPGRDPPRVKITSLEHEIFFTLSALANTHTLQARLALQPLYLTNTAPVGTTQRQTAITTATRHLLDAASIYDYLCTRPTTTTSSSSSPPCADLTPSALSAHRSLALAEATLLAVLKDDPYPTLAFQARNKHDTEWMYKAPDVPRVRAHLFARLCLAAAEHAAQAAALLASAEGGGSGAGELVRFFGVDAELGGETGKGIAWLRAGLQELGVEDGKGSKAGRLKGLKKEWSERREDKKVERGLDWGADGGRLEETRVIEMLEAKWVKQNDTILTQPIPPVGPLFAEMPSGREIHSIKPYQPPVLETEVLEAMRAPPDRAEEVGNYASSDEDTAVDSAVPGAFPGRPGEYRTDTPGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDC0</accession>
    <name>A0ABR3VDC0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Cysteine dioxygenase</fullName>
            <ecNumber evidence="2 7">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="2 7"/>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="224" mass="24612" checksum="7738EB04F2EE726F" modified="2025-10-08" version="1">MAIGLIQTSPATESSSSSSAAVVGCRATIDTNRFDELVLALKEALGPCSGLTSDDVDVNHLMRLMRDYDSDPREWARFAMADESRGYTRNLVDEGNGKSNLLVLVWTPGKGSPIHDHGNAHCLMKILHGDLTETRYAFPDGEEGEEKPMRVISERVHRKNEVAYMADELGVHRVSNQGSDFAVSLHLYTPPNVARGGCHIFNAETGKKSHIKNCGYYSAYGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDN8</accession>
    <name>A0ABR3VDN8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose receptor Git3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="48380" checksum="6E37F63BA51AB263" modified="2025-10-08" version="1">MADSSSSSSSYRPLAPESDTLSPLPGVHRRGLIACTVLGCLSFVTSTTVFLYLTVKFVRWHIRTRKQARKDAENSGSPQVDLALGLAERLFVGDEAAKPPPPPLKKKRPHPNQFLVLIYNLLLADIHQAASFILNAVWVGRDALDVRTATCWVQAWLIQTGDVASSLFITAIAVHTYLAIVRNYTPPQWTVYTAVVALWLFNYLLLVLGVAITDNGKEYGGFFVRATAWCWINVRYEGLRLYLHYLWIFVALAITGALYTLIWLSLSKRQAAAIKAQLPAANESSTNINEQSNDDTTTNNHNRTISTSSSLGKSHLHPSTTAVSGPSDSTAAAAAPNTTTTTTTTTTTTPEQHPPPPLQGGHHKAFLLYPIIYIFCTAPLALGRIATMAGVDVPVSYFVTAGALITSNGWLDVLLWGVTRHRLIFSSDAVGEHGLGGGREGRGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDY4</accession>
    <name>A0ABR3VDY4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="246" mass="28220" checksum="B9C50E88DCE219AC" modified="2025-10-08" version="1">MPAKLPRNALGWITSADGQTTVNSVPSVASMAEDAAYQEDSPFEDVQPTPADLPSVEGFKYFLALPAEIRVKIYDLVLWIPEGVYPEFLSMERVDKVYFDSLFDKRIRPDLGLLFVNKQVAVEAAARFYSINTFHFDAVAVFLFENIFAEYKCEWIGRNALHVRQLEYKIAITDSRNVHRYDSPLAKLCPLLPNLQSIVIRYEPYNRLDRFFQIGSRVEDLRKLMSTVFQNVEDVQLVADPGRPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEI3</accession>
    <name>A0ABR3VEI3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000127">
        <property type="protein sequence ID" value="KAL1840103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF159">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="794" mass="87032" checksum="67CB1EF87AB59AA0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEK8</accession>
    <name>A0ABR3VEK8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000138">
        <property type="protein sequence ID" value="KAL1839846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="264" mass="28750" checksum="32382F5A020140CA" modified="2025-10-08" version="1">MPSPRRYRVLTYLIVAGIVTLLFFASQSRDQAATSTRAASSAKGFYDKTVEAMDKHKHAHAHGGSDQKVVAEHGDIHEDADALHRGVADRLRQAEQAAKDSAEAKGPKQPEVLQHVVGQENLDPAAVAHEKAKGKGGEPQRDREVEEVLNEIMKKSPVIIFSKSYCPYSKAAKGILLEKYTIEPAPYVVELDNHPLGSRIQARLGEMTGRRTVPNVMIYGQSIGGGDEVSAMDRSKTLADKIQSLAGDRVAVSLRFEQGKEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG10</accession>
    <name>A0ABR3VG10_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000105">
        <property type="protein sequence ID" value="KAL1840613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046774132" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="27"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="220" mass="25005" checksum="FE8ED2C5E0F3834F" modified="2025-10-08" version="1">MRPLLLPLLSLAGMARALYFYIDVTQPKCFFEELPKDTLVVGRYLAEEYNDQRGVWERHDGISVYISVDEIFDNDHRVVSQRGGSQGKFTFTAAESGDHKLCFTPSSNSGRSGWLSAASPNGGIRLTLDVAIGETTTLDGADKTKMEDLATRVKDLNARLNDIRREQVFQREREAEFRDQSESTNARVVRWILIQLVVLTVTCTWQLSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG30</accession>
    <name>A0ABR3VG30_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="776"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="879" mass="98406" checksum="CC904DD8714577F5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG62</accession>
    <name>A0ABR3VG62_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyisobutyrate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="3">
        <location>
            <begin position="180"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="42975" checksum="79F6E16776BE337C" modified="2025-10-08" version="1">MADSKPPIAFIGLGAMGFGMATHLLKRGYPVTGFDVWPPTLERFRQAGGQTANSPAAAVSGKPFCVCMVATAQQAESVLLDGPDPAAPALAQGATLLVCSTVPCDWIRSLQRRLRDELGRGDVLLVDSPVSGGAARAAEGTLSIMAGLSDEGEEGLARARPLLEELADPEKLYIVKGGVGAGSNMKMAHQVLAAVQILAASEAMGFAQKLGLDLTAAQKGVLESEAWNWMFEHRTPRMLTQFQPVASAVNIIVKDTNIILDEARRGGFPVPMTEQAAEGYREAVEKGYGPDDDSSLLRLYTEQGDSKEGSGKSDQEKLGLVVELLKGINLCAAAESLSVAHAVGLDLDQVLDLCVNAAGSSTMLKRHGPEFVTALRVGATDELRQASESEPRISEVAEKLEKPRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGP0</accession>
    <name>A0ABR3VGP0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
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            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="397" mass="44336" checksum="592F3E4BA8C436C5" modified="2025-10-08" version="1">MAPLKTYLLSLLLTASPLLAHKRDLPIPEFTQEEIDSGAALRELNRIAGANAHRLFGNNCSPATVKIRREWRALSKPERRQFIAAVKCIMAKPNTVLSQDEVPGAKSLYDAIVWAHADRSGYMHMSGNFLVFHRYYLHTYERELALCGWDQGLPYWEWGLDVDAPHLSPVFDGSDTSLGSDGAFIPNRPPRVLDFIGFDEPTIIPPGTGGGCVMKGPFSDMVVRLGPIDVLPGEPIPSHPEEGREENPRCLERDLNADPLRRWNTFRNVTELILGYRTIREFQGTLDGDPRVTRESMGAHSGGHEAIGGIAVNPMLSPYDPAFWLTHNMLERVYWIWQLLDFKNRQGVHGTGTFLNMPPSANVTVEDELDLSPHNGPVKIKDLMNSLSGAPLCYVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGQ2</accession>
    <name>A0ABR3VGQ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nulp1-pending protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000094">
        <property type="protein sequence ID" value="KAL1840921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="85395" checksum="12786F04DBAAA692" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGW4</accession>
    <name>A0ABR3VGW4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61113" checksum="023C0784D41A9428" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHF8</accession>
    <name>A0ABR3VHF8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000100">
        <property type="protein sequence ID" value="KAL1840753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1275" mass="135503" checksum="A4A10EB40F0E89FD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI69</accession>
    <name>A0ABR3VI69_HUMIN</name>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1841559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VerF-like"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="174"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="601"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="941"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="31"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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        <location>
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        </source>
    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1841559.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1172" mass="125841" checksum="E3E2592E00E0E35A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VII7</accession>
    <name>A0ABR3VII7_HUMIN</name>
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        <recommendedName>
            <fullName evidence="8">NodB homology domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Humicola insolens</name>
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        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000085">
        <property type="protein sequence ID" value="KAL1841158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
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        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF9">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046854019" description="NodB homology domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="253" mass="27673" checksum="5181FDF171442668" modified="2025-10-08" version="1">MLAETVLTGLLLASSAVAYPAPNPVQFLKRAPDAGVVIQKCANPGMLALAYDDGPYQYTSQLVDILDRGGAKATFFWTGTLYGCIYNQAAAVKKTFASGHQIASHSWSHGYMGSMSESQIRSEMTRLEEALVNLIGKKPTYMRPPYLQTSGVFLPTMRSMGYKVITNDVDSGDWNNQSPQQSQQAFQRAGAHGNGHISLMHETYASTVNTLTPWLINWANQNNLKLVTVAECLNDADGMYQPGNFTGNGRNYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIN4</accession>
    <name>A0ABR3VIN4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7057</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="12">
        <location>
            <begin position="141"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="12">
        <location>
            <begin position="314"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="543" mass="59703" checksum="82AD6704CCEBFCDF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIT6</accession>
    <name>A0ABR3VIT6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="202"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="302"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="398"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="561" mass="59685" checksum="BD666B3656DBEDD9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIY5</accession>
    <name>A0ABR3VIY5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Catabolite repression protein creC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="67257" checksum="BC10DD6ABD227B34" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ27</accession>
    <name>A0ABR3VJ27_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="18"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="367" mass="39379" checksum="EA1569C0635107B7" modified="2025-10-08" version="1">MSTQDYKFEGWLGFDKSAADGNMQWAEFEPKPWEETDVDIKVTHCGICGSDLHTLRSGWGPTKYPCCVGHEIVGTVVRVGSKAEGGLKVGDRVGVGAQSDSCLGRKGPCQACNSGLENYCPIAHTGTYNGVYLNGGKSYGGYALYNRAPSHFVVKIPDAIPSAEAAPMLCGGVTTYAPLKHHGAGPGKTVGVVGLGGLGHFAILWAKALKADRVVAISRSSSKREDAFKLGADEYIATAEDENWAAKHASTLDIIICTVSSSPMPLTEYLTLLRFDGSLVQVGAPEDPLPSVPLFLILFKRLKITGSVIGSPDDIREMLQLAADQKIKPWIQEIPMKDANRAIVEMAAGKPRYRYVLVNEPQIKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJB5</accession>
    <name>A0ABR3VJB5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitronate monooxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27112" checksum="B410FC96047237F7" modified="2025-10-08" version="1">MASPQQIRTPLTDLFKINHPILLAGMNVAAGPKLAAAVTNAGGMGVLGGIGYTPEMLREQIAELKEHLVDKNGAFGVDLLLPQVGGNARKTNYDYTKGKLDELVDIIIESGAKLFVSAVGVPPRHVVEKLHKNGILYMNMIGHPKHVKKCLDLGVDIICAQGGEGGGHTGDIATTILIPAVVDAAGAPEAHKEAVRTAGFNDTIRTVIFTGRPMRVRKNPYIVNWEEERQQEIKELTSRGKIPYEADLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJK6</accession>
    <name>A0ABR3VJK6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="8">
        <location>
            <begin position="786"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="908"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="122795" checksum="3C749C34AC9CF660" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJS1</accession>
    <name>A0ABR3VJS1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6129</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="673"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="781"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="831"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="34"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="226"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="577"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="938"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123296" checksum="86221D477E1B6E05" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK24</accession>
    <name>A0ABR3VK24_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF12">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="599" mass="67042" checksum="68F6345DC1AF09C4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK25</accession>
    <name>A0ABR3VK25_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000059">
        <property type="protein sequence ID" value="KAL1841937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="428" mass="47572" checksum="31B4DCB0FD1A6A5B" modified="2025-10-08" version="1">MDEESAWSGLENGIEDQEELHVIYRTLDSYQQYAKIAHFQCTHLRRQAFYALPRAHWQRLAAPPFNYLETLDKVDDAIESNAELARIIFRNGLDMFHIGVPSESGGGRSLALPPEWNGSAKPGDVEKARSTLRQFYRDWSAEGAREREACFGPVMRAIAAERAARGPDAPPLKVLVPGAGLGRLVFELCRAGCDAEGNEISYHQLLASSYILNCCPRAGHHTIYPWIHTFSNHKTRANHLRGYAVPDVHCASELTRTEEVEGRPVGTMSMSAADFLCLYAQEDRADAYDAVASVFFLDTAPNLIRYLETIFHCLKPGGILVNIGPLLWHFEGRVWDRDEHDDVSTEGGHSRDISGIADPGNFELTNEEVMALVKDIGFEVLEHETGIEAPYILDTESMLQTSYRASAWVARKPAAPANATTTTAPIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKA6</accession>
    <name>A0ABR3VKA6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ureidoglycolate hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31158" checksum="D2DF1DBEABC8A181" modified="2025-10-08" version="1">MPPKHTVLLQGPPIVIDAAPLTREAFAPFGDVVENPHPDLHPSVFAKDPSPLPFSAVSANQGSAIKYQHVSHQINLYNQARSGRPGSAIMSMFVCAARARVPDPHEEESAPAPAPTPTATPPRTETSPRQLPTTFPVIVLERHPFTTQTFIPLSKDPAAHYLVIVAPTLAATTTDSSTFAVPSQLPPSAKYPRPLPGAGLPDLSRLHAFVAGPGQAVTYGAGTWHAPMVALGETGTTAVDFVVVQFANGVGEEDCQEVLFERQGSEDAAAPVLVRLRPLQQGTEEGEMTRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKC1</accession>
    <name>A0ABR3VKC1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000059">
        <property type="protein sequence ID" value="KAL1841931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="398"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="573" mass="62870" checksum="E536B3BF09F43418" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKC8</accession>
    <name>A0ABR3VKC8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
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        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="410" mass="43613" checksum="EDB3B150B2CCA5A6" modified="2025-10-08" version="1">MTTLTDRERIILGDLTTVFTPPAHCTVAIGLGSKNDVAWWGQTCSPSRPRDHAGCWPPATELEDFRPPFSGGGFYSPGLSCPVGYRTACWAVEGGKSEWRVQFKMEPGETFVGCCPTGFNCWNLNGQTCISAVTSDAVPTASCQSGSYVNFGLTTLPNEFVTSMNLFAPMIQLAFKESDRPERTTTTTSSTTTTPSSSSRTSPGQSGSRATAPAEASDAASNGQTQQPSDNNSATADTDTGLSTGAVAGIAVGTAAFLLLIFAAAFFVWRRRRRGGIAYQPGPTNPADGISSPPTYYTGPSPPMSDAGMSSRADEIKPFPHYYVPGAGMPVEMGQGHERFEAPGLESQRAEMFAGPRQFGDHAQQQQPPAYYPQVWQQQQQLQTQGGGYPGMYAGGAGQGPVEMPAERYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKD1</accession>
    <name>A0ABR3VKD1_HUMIN</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
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        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="270"/>
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    </feature>
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            <begin position="10"/>
            <end position="20"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
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    </feature>
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        <location>
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            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="504" mass="54701" checksum="070D0CA413F56608" modified="2025-10-08" version="1">MPLTFERDTGPTNSEHSTAGQPRWMPADAGGRAVERHTRLSDRNEETSALQDEQYELDETLPPSLSPRRLPNGIPLSPTYQRLLSHFAKDILASLSCHPSIHQDLLDGLVPVSLESPHLMSACLALSAAGFLSRGVPALDGVDISKILGHLQSSGLSLLRSALATNQMNGTLVATCLLWCMTEIFTHRQGTSSWRIHLQGIRALLDGDGAQRSLAFPTGATRPAMKHLHQLYLSLRTLPYIPASESPTSSPDPTSPDSDDSPKIPPLDPTPASPAIDGFLGYSDELLDIIHEINHLSSIHHSAVPTTTDISPIDPTITSSTPSPAPITPVPFEADLLLGKLHAMILRDSRHPPRVAGITTPLTTETGREFALSHAIFQQATLLHCYRKLYRLPSGSAPVRAAASALRELLTRLEREAAPAPCRTWVAMAMPVFNFGCEAVDEGEKEFALEMVGKLAGCIGSSHVGSIRQALRDVWELRDRLGDREGALCASELLEKLDYNVVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKG1</accession>
    <name>A0ABR3VKG1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell differentiation protein rcd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046932898" description="Cell differentiation protein rcd1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1407"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="1517"/>
        </location>
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        <location>
            <begin position="1608"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="510"/>
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        <location>
            <begin position="662"/>
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        </location>
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            <begin position="676"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="782"/>
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        </location>
    </feature>
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        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="876"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="905"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
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        <location>
            <begin position="948"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1445"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1484"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1672" mass="170885" checksum="73201DAA152C886F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKQ0</accession>
    <name>A0ABR3VKQ0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="225" mass="25439" checksum="2F91E9DA45567118" modified="2025-10-08" version="1">MTQVGPVSAFCFPVDSLSSVSCLVVGLFLNPRRFTCDSGLGPVPAAAHPTKFPVGFLVAQSIWRCLLRWTNAQKVEDPRIRWGGECERRGSGRASSDRLMRSGSKFAVVASLLRLPRENVSRERNGSKWVRERAARLRRNRRLKESWEWKEGKFGRSGLLLGAAEGGPREKVGLGFWNLDFATSISIQFQFKETIPHHANKHNNTNCPTRHYCRWSVLLPFSIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKT8</accession>
    <name>A0ABR3VKT8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="724"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="898"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1099" mass="117094" checksum="FDE324B2F03C5A74" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL10</accession>
    <name>A0ABR3VL10_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="794"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="903" mass="99193" checksum="9E11F61D7861B8F8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLP1</accession>
    <name>A0ABR3VLP1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="139" mass="15291" checksum="223D836859DBD624" modified="2025-10-08" version="1">MASPTRSDSSRMGRRDSSDRSVGARMPRLLRATVTTEPSITTSNASPNALATQPGRRASELLSRMAFVSGSPPDATFRRTSMYDSVDRHGDLSSSPVSQAESFDELHGHECGARYFSFPSFDLYESSQQYDDEKSEPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLS0</accession>
    <name>A0ABR3VLS0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="236" mass="25161" checksum="32364FA496A2BB67" modified="2025-10-08" version="1">MSSSSYAPPYYADYPTDALPIPPTKGQYGYGASSGYPPYGYPSTAGGCYYPSGGESAYSSSPPDGEEEEDAALRAASVSSGSAYGRGYSHTTTSYAGRSSDYYDSTAASVTGSTGSSSSSSGAGSAAGVDLHEYMQDRFAATFDPIALDRCTATQAQTSGHLNAKHRELLELQAKAQARLAQTRARFARGLEDAREVRNDLEWTQKKLESLKAKASKKHPKEYARARARYPSPDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM47</accession>
    <name>A0ABR3VM47_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="56132" checksum="A4CD68C8C536A9CB" modified="2025-10-08" version="1">MDLGHETQTLQAEDGDLKRQARIAPRSSRTSLERSSQPHRIKKKRSPYEAENRIGTHLTRQLHACVRCRMQRNRCIPDPTNPRGPCLTCQQRTVRMSRLPCLRYMVTDSTLFRTGLDYMPFYRDHPMVGPKYGDFHLEREWTAAKPKVLCIGQVGSLHLQIEVREFVPPPEAAADVDLKGRPMYAVPWAIADPDAVVVAMEEYINRPIVRYMDEYLDRSDPLVWNIFQMAYRASVFPVPNEMLKKTLRLWVASRFIESKWRCWSETGWADDEIRALNPQDPFYSDLDSLPPYIDYQVASIVIHRVLGPLRKDVLRILQATLNTHHPADWFATFLTCFVLLKNYEMQMRFQREFAMRRRAKVRYLDMPLVRATNSGAKTILAHFHYCYKGQKLFSEGFDWNAPRARRMARLDPEQCEFMARCRDVVVQRASKFRAINHSHVYHEAWWYTSQLFDPEWTPRETLEHAPQAKASIELERVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM78</accession>
    <name>A0ABR3VM78_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">6-phosphogluconate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_3902</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="11">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="12">
        <location>
            <begin position="179"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40873" checksum="1A60FD0E8E92B242" modified="2025-10-08" version="1">MAPKLCWIGLGNMGRGMCKNVVKKADVQHPVLIYNRTKQKAVEFSTMFEDGEVEIVDSMAAGVAKADVIFTILAKDDVVEAVVDDILGSVDVKGKLFVDCSTIHPDTTVRVSKRFVDAGAEFVAAPVFGAPAMGEIGQLVGVLAGPKESVQKARAYFKGVMAKAEIGMSDLPYEKALQLKLIGNTFILNMVEQISEGLVLSEKAGLGTKYLYDFIHLIFPGLFAAYADRILSGKYHTMDYPLFPVDLAIKDARHALSLAETAGVRMGNLDVGMAHLQEVKQHQGEKGDIASIYGAIRAQAGLNWSVVIGLVIVIAMCVAAWFFSPKGENQVLWRSSIILSIASCYLMWAVTFLAQLHPLIEPRRSDLRKEYIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VML4</accession>
    <name>A0ABR3VML4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_3335</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18660">
        <property type="entry name" value="CD1_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18196">
        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="277"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="377"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="475"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="793"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1085"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1343"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1571"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1086"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1103"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1398"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1571"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1594"/>
            <end position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1843021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1682" mass="194518" checksum="D07A7FB6A0B55EA7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMS1</accession>
    <name>A0ABR3VMS1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="62670" checksum="0235ACAEE272B8CD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMT8</accession>
    <name>A0ABR3VMT8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-1,6-mannosyltransferase MNN10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="54799" checksum="8DD5C1038B76115B" modified="2025-10-08" version="1">MSLSRSTSPIPGGGWATPGLDITGGRSSPTRALSGTPAMWQQSSRLGRNHGGGGYGGGSNHNNRYPSFSTRTQGFFGRHMRRLSNSLPRFNSSPYYADKEKLGRERWSAQNATLPGRIRSILGRMGRKMKTRLLFLLILLSLLVFFNSPGTAFVYWWRRSSWFGGGEKFVIVIGANVGGGVMDWKGGKEWAIERHSLRNKKQYARRWGYDLEIVDMKTKKRYAHEWREGWEKADFMRQALKKYPEAEWFWWLDLTTYIMEPSYSLQRHIFSDLTKHVYRDINEFNPLNISHPFTDPYLDAESRSPVGDGRPESINLLLSQDCSGFNLGSFFFRRSEWTDRLLDIWWDPVAYEQRHMEWPHKEQDALEELYTSHPWIRKHTAFLPQRMINSFPEGACAKEDGARDERFHYDKKDRDFVVNMAGCEFGRDCWAELSGFKDLSYYLNRSWWERFKEDVVAVAWKKVAGRKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNH5</accession>
    <name>A0ABR3VNH5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP cyclohydrolase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="99"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="319"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56298" checksum="118D5B7D8CC71133" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNM0</accession>
    <name>A0ABR3VNM0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diaminohydroxyphosphoribosylamino-pyrimidine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="35881" checksum="F9C088922C4AD525" modified="2025-10-08" version="1">MTLRGFLQALGAPVQDVEEETFDLFAQDLPSQNLGFVDSRASTIDITVAGRDLTIHQSPAVLSSNRAGGTTGAVLWKVTPLFAEWLAAPTNPLFAHGVLSSTSVVLELGCGVSALVGLLLAPRVARCVLTDQPYVARLVELNIAENAKAAAASPRGGTPTGELRKGHRERGTRARKGEKASSPGLAGADLRGRVCFAPLDWETDAVTPALASWSGVGSPPPTTTRKINNNTSGNGTRTQTFDVVLACDCVYNEALIEPLVSTCADACRLRSRDRADDDSGDGGREDIPPTVCVVVQQLRDPSVFEAWLECFSRYFAVWRVPDELLVLPGLKSNSGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNN0</accession>
    <name>A0ABR3VNN0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20431" checksum="38410DBCEC0053BD" modified="2025-10-08" version="1">MAQEQSMDLPIIDLDVFLQQPRDSEALKAECARAADALITYGALVLHDSRVSMSDNDTFLDLLEDYFAQPEEDLKKDERPEFAYQIGVTLENTEKPKCAVDEPCLRVIERLAPSERPLDISGHEPDPKCRFFWRMVEPPPYETRFPVLNADNVVPEAPHIRQRWTPVMNQWGTSMKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPF6</accession>
    <name>A0ABR3VPF6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="118"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="463" mass="51749" checksum="4A5D573C9D8EB9C3" modified="2025-10-08" version="1">MGSMSCEPEGFVFDPSPLFSRRVQRWEPGAIRSLLPLEAIPGMISLVAGKPNPATFPFAKISITLNGPEEKTITLEDAVLSEALQYGLPAGHPGLLKWFEGLQQAVHGIEKSGSWMCCVGNGSQELIHKAFQVFTDPGDAVMLETPAYPGVSAFLRADQMELVEVGSSRDGIDPAHLERVLESWPRDRELPKVLYTVPTGSNPTGVTCTEANKARVLRLAKRFNFMIFEDDAYYFLNFEEDPAKRARSYLAMEQEVNGETGRVMRFDSLSKIVSSGMRLGILTGPVQAVQRVVKITENINLQPSSTTQVLALSLFRHWGYQGFLEHCVQAADFYRRKRDAFAAAAERHLQGRATWEAPSAGMFFWLKLILPPGYDSFDLLSKKGIEQRILAIPGMAFLPNMRAACQLRASYSLVSEEDMQEACRRIARLVDEAWLEDFLEHAKTMARHKQAMLMQRKGEVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPI4</accession>
    <name>A0ABR3VPI4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="74" mass="8613" checksum="967282B15E4FCCAE" modified="2025-10-08" version="1">MHPSLEQMYELQKAGKDLYDLDEAYRATQEGRPPRPAATYPPPVNGFWTQTELRRPRGEGGFHPYTRFNVDCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPN4</accession>
    <name>A0ABR3VPN4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32317" checksum="3E68C3FE5CFF9298" modified="2025-10-08" version="1">MNAAATRITALRNLRPVASRIQPLSLPRIVTARSFSASASHNYEYIQVSEPRPGVGQVTLNRPKALNALCTPLINELNSALREFQSSDSISAVVLTGSERAFAAGADIKEMAPLTFSAAYRGNFIESWSELTTALKKPLIAAVSGHALGGGCELALMADILYCTRGANFGQPEIKLGTIPGAGGSQRLTRAVGKSKAMELILTGKSFSGEEAERWGVAARVFESYEELLKGALDTAETIAGYSRVAVQAAKEVVNKSQDLALRDGVEYERRVFHALFGSQDQKIGMKAFAEKKKPEWSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPT4</accession>
    <name>A0ABR3VPT4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">VTJ49DRAFT_7482</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046814391" description="triacylglycerol lipase" evidence="20">
        <location>
            <begin position="38"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="21">
        <location>
            <begin position="291"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="570"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAL1843772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="679" mass="73110" checksum="D7C221E2987BEAE3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPW3</accession>
    <name>A0ABR3VPW3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="723" mass="79547" checksum="460CA45045C711E7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQJ0</accession>
    <name>A0ABR3VQJ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="264"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="774"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="791" mass="89726" checksum="7F7E69DD6DC8570D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRB1</accession>
    <name>A0ABR3VRB1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1844189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="58" mass="6392" checksum="14E6B20FA4F5946B" modified="2025-10-08" version="1">MFMGTPHEGSWMAKWASLPAAALGLIMPTNEALLDILETSSEHLESVQVEFWSMSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRC0</accession>
    <name>A0ABR3VRC0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1844135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="551" mass="61529" checksum="553059BEB1642240" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRM6</accession>
    <name>A0ABR3VRM6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="80" mass="9519" checksum="49DF7C865446433C" modified="2025-10-08" version="1">MHPLLHTKDNAGCEQVMIALEECHARGFLWKALGMCSNAKEQLIKCLREERVKHQTMNRTEEQEKRARIRQKWKEIEENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRP6</accession>
    <name>A0ABR3VRP6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_11</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="357" mass="37660" checksum="354B086C8CEE163A" modified="2025-10-08" version="1">MLYDLNIAWSPGTPPVELERTLRFAKHLGYDVVALNHIISGPIPTQPTPITNPIPRLTPPHSSYPGGSNFSSSTKPSTSTPSTTTQPTPPPPQPTSSPSTNPLPTTLRRATLIITDPSTTNYRLPDFARAYDLLALRPTSDKSFAWACTSAAATSAGDPPAIISLDLSSHLGWHVHHRTAMAAVARGVRFEVCYAQGLGSSGSGGVDKQRVRANFIGNVQSLIRATKGRGVIISSEARGALGLRAPADVVNLLAVWGLGPEKGFAALGEGPRSVVVNEGLKRRGFRGVVDIVRTAEGGEQKQDGEEGKQRQQQQGQKRKNGDGGGGGGGGGGGGQQGEGLSKRQMKKMRKEAQQKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1Z2</accession>
    <name>A0ABR3V1Z2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000533">
        <property type="protein sequence ID" value="KAL1835808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046972360" evidence="1">
        <location>
            <begin position="16"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="248" mass="27131" checksum="CF84564E8B928D83" modified="2025-10-08" version="1">MKSTLLLFLPTLANAITLPLPKNTTNNDPNKPIRNNPVRAGALLVGAGFEVVHAVVHIPNLRVAPGADPDQLHAVSAWIGVDEEETCPGTYLRVGVDMFLNSTGTWYLPWFGWHPNNTNHLPSLSILPGDWLGLHIQAANLTFADLTIKNRRTSQSCHAMAEDHPTLLCGFSALWMVEGHWTTKGLPLPDFGSIVFDEMQAVTSTAVDREIEDAYIEKLVEDGDGKPTVEPVRLGNDSLMLKYIGGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V233</accession>
    <name>A0ABR3V233_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000529">
        <property type="protein sequence ID" value="KAL1835827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="92"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="343"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1124" mass="124459" checksum="E7F8D44DE0B96E44" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V258</accession>
    <name>A0ABR3V258_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000522">
        <property type="protein sequence ID" value="KAL1835858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="172" mass="18109" checksum="46781FE4F673351D" modified="2025-10-08" version="1">MAEKPQGQKKVEAWLRTLGDEVCPEKEGGGVSGGPQDPGIHDLGLGPAPPRNFNGTTRVSRPQSRVSQVNNPTVRPTTSVDVSPVSGANSIPLGKTRHEPQPQQSSTSSTMEAIASPRITCAYLNNYVGKNVTIVGKVLQLRGEEALIDADGNITAHLNRVSPILPSGSPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V268</accession>
    <name>A0ABR3V268_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000704">
        <property type="protein sequence ID" value="KAL1835368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="163" mass="17309" checksum="811D2280229798A3" modified="2025-10-08" version="1">MDSTDKTTVDVREANPPASAKGDEPKAPVENGTRSVEAEAKIDDKPESTKKSLKEKCSKKHPKRKSAKKRKKAASSSDSSGSDSDSDGSETSSSSSSSSSSSSSDDSESEAEASKKKRVVKKQPQPEGAKRKTRTKKPKKVSKSNDLSGSDSDSDTSGRCQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2J1</accession>
    <name>A0ABR3V2J1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000588">
        <property type="protein sequence ID" value="KAL1835621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="840"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="878" mass="98158" checksum="C8E6988E367E12D0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2U1</accession>
    <name>A0ABR3V2U1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">VTJ49DRAFT_5898</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000511">
        <property type="protein sequence ID" value="KAL1835907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="21">
        <location>
            <begin position="524"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAL1835907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="651" mass="74943" checksum="93662F8037E112D3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2Z8</accession>
    <name>A0ABR3V2Z8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000455">
        <property type="protein sequence ID" value="KAL1836159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="54333" checksum="D388EF908956D2A0" modified="2025-10-08" version="1">MTQTRRGPTMDEARRAPLMMETYYGAVRSPADAIKLFEACRLGLLPRVQRRLSEKERQAIRSGSVFVWDEREAGMRRWTDGKSWSASRVSGSFLTYREMEGKRGNAFGGSRRGAGKTPDSGRGSDEDQDDGEPDGYRYKPDGLTKQSFSITNSAGQHLHLIAYYARGPLDLIQPTNDPALRHIIPAKGMYPESSLAETSSRAPLHQPHYSHHAPPHHGYPPPYPHPSYGWPPSPVSTPPYAHGHHYPYPPGPPPPHAYHHYPPHPPHHFSHPPAYERAALPPPPPPPQSAHPQLPAPLPPKTLSQPYPQNQHQSPPLPPPRLSVMDSPRSQQLQPQAREAVQVEPRLAPIEATHSSHRSPRSSPRQQPAQYHQPPSLPVPNGSTGPVSPTASPPRSAISPTTTTTDAHGSRTESQSSTTAPTPASTRPSLSALLLHPPPTAGSEPSSANPTSAGTVATGGLGSSLGSGGSSPGGGGPGSQGALAVAAAAVARVGGEDARAIGALNKNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3T1</accession>
    <name>A0ABR3V3T1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000414">
        <property type="protein sequence ID" value="KAL1836415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="223" mass="25273" checksum="0E682CE65CF93ECA" modified="2025-10-08" version="1">MITSSAVSLAARQAALTRAPSALIRTMPAQLLVARRGYATPAGPPPKNFRLRPPTEWDQEKESTIDKVGKYFLMTEMLRGMYVLLEQFFRPPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLANGDKWEPELAAAIRADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3T8</accession>
    <name>A0ABR3V3T8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000417">
        <property type="protein sequence ID" value="KAL1836390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22676">
        <property type="entry name" value="FHA_SNIP1_DDL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="170" mass="19226" checksum="2673C927DC8B12A1" modified="2025-10-08" version="1">MSRGEAPEKPVEKPNFGNSGVLAAASNSVVQADGTTITLKYHEPPEARLPRDSWKLFVFKDQDIIDTIELSTRTCWLIGRELAVVDIPAQHPSISKQHAVIQFRYTEKRNEYGDKIGRVKPYLLDLESANGTMLNQAKVLESRYVELRNKDMIQFGSSTREYVLMQAAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4C8</accession>
    <name>A0ABR3V4C8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000390">
        <property type="protein sequence ID" value="KAL1836610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="106" mass="11298" checksum="60EACF41B685D3F6" modified="2025-10-08" version="1">MGPPSSSLAESSELLWYSAILLCFLAGRVARPLGPSLKERFFIDEPMLVRSRMGHLNEVVVSSFAKSAPASSFPAIVIEAIATAVTFKTYAGINAVPLTLFLLGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4L0</accession>
    <name>A0ABR3V4L0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000375">
        <property type="protein sequence ID" value="KAL1836713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="523"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="604" mass="67146" checksum="249DEA76860A4C61" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4R5</accession>
    <name>A0ABR3V4R5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000416">
        <property type="protein sequence ID" value="KAL1836401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="216"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
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        <location>
            <begin position="889"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1836401.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000366">
        <property type="protein sequence ID" value="KAL1836789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF50">
        <property type="entry name" value="MFS SIDEROCHROME IRON TRANSPORTER MIRB (AFU_ORTHOLOGUE AFUA_3G03640)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_1"/>
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        <property type="match status" value="1"/>
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        <location>
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            <end position="112"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
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    </feature>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
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            <begin position="90"/>
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        <location>
            <begin position="20"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="607" mass="67115" checksum="1979A0CA619F6047" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Z8</accession>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="118"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="EMBL" id="KAL1836358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="153" mass="17088" checksum="6AF7988A111D8728" modified="2025-10-08" version="1">MALLAASASQSPPRISSSLTHQQHSNLLSTLYPLLNTALQFQRLLSSTAFHLVIHAYYTAATLATLSAWASWSVAWHALLTTRLVAAQAWLLARRLAWAAWDSKRSRRARKRLEHEMFVLLLGPGGNTLLLMLFWPGWLMLGVLGWGVWLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <organism evidence="2 3">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
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                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAZGSY010000375">
        <property type="protein sequence ID" value="KAL1836710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="300" mass="32424" checksum="51B63BBCCCBE40C8" modified="2025-10-08" version="1">MDAWDDEDIEIDPLLNKIIYGVLHHPAQRDMGPDGASEGRRIIYNTVKEWWNDMDEGQREDYRRKLSREGVQNGDNHREGEHDSGHGCGHKLKMKKNFRNEAPETLEDKIAGAAATAIFSGVKQSVSNTVQSAASGQAPQEAVGSGFGGFFDNVKQSFKSALKEQGIGGGGGSGGLGGLMSSFGQGRRDEEDRPSYSQQSSSQYGSGSGGYGGSSSGYGRRDDDEHEQSYGGGYGGSSGYGRRRDDEDNEGYGGGYGRRRDDESEGYGGGYGGRRYGRRDDEEEEESHGYGGGYGGGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V596</accession>
    <name>A0ABR3V596_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000347">
        <property type="protein sequence ID" value="KAL1836937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="66" mass="7068" checksum="2123348401E774D2" modified="2025-10-08" version="1">MRGLARMYDCMSSFILAKVLRAFFEASRDLTGIFENSPVTVTVVPTGAATATESQGSSTKVGHIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5M3</accession>
    <name>A0ABR3V5M3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000333">
        <property type="protein sequence ID" value="KAL1837067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="199" mass="21931" checksum="02A97F0EFCBFEE35" modified="2025-10-08" version="1">MSAVQSIKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVQVDGKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLISPPSFDNVLAKWYPEIDHHAPGIPIILVGTKLDMREDKETIEKLAANRMAPITYPMGAARAEEIKAYKYIECSALTQVNLKAVFDNAIRAVLDPNRGAREAPKKKNKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5W0</accession>
    <name>A0ABR3V5W0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000323">
        <property type="protein sequence ID" value="KAL1837154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="638" mass="71544" checksum="BD2CBEB04E6FA812" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6B4</accession>
    <name>A0ABR3V6B4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000329">
        <property type="protein sequence ID" value="KAL1837107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="74"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="331" mass="36513" checksum="6CA52A42D954283F" modified="2025-10-08" version="1">MADTAIVNGNSNADTLKSNATAAYKTVTNGPVAQNVMEQSLKTSDEISKLAASRHTPDYTAANGQPLTHYHSFFSELLSWRNPRASAIAYASTVSLIFVFRYLDVLRWAFRLTWITLAITVGAEVAGKVLLNNGFITQLRPRHYYTVPKETLNTVVGDVHELINFFVIEAQRVLFAENVYASAAAALAAFISYYLVRVVPYWGLALIATTMAFFVPLIYTTNQELIDSQLKHAGEIVNAQTAQLRTVAQRHTEQAAQVTKQYMGDYTAKAQALLKNARQNKTATGPKPDDFPAAPKTEVKPEPEFPAVPKDDIKAESEEVEHAETEPMIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V762</accession>
    <name>A0ABR3V762_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_3566</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Vacuole membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000277">
        <property type="protein sequence ID" value="KAL1837627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1837627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="172" mass="18017" checksum="F9DB4624BBD7348A" modified="2025-10-08" version="1">MIPTDPDSINLDRCPVYASFFGALGCAFSIIFTVIGSSYGTAKSSGAIFSCGVIRPDRLMQNTLCAIMAQIISIYGLVSAVIISNNLVEKLPLHTAFLQLGAGLAVGLCGLAAGFSIGIIGDAGVRASTQQPRLYVGMVLILIFAEVLGLYGVIVSIMMLTRSTLGVTQCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7F8</accession>
    <name>A0ABR3V7F8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000269">
        <property type="protein sequence ID" value="KAL1837717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="48547" checksum="009982BBA3282CEC" modified="2025-10-08" version="1">MASQTPAVVMDNGTGFSKLGFAGNDSPSFVFPTAIATKGPAAGATSGSSRPAVTQKPSFLTGGAGPTGHLSAKRGTEDLDFFIGDEAIAAAGGPGYGLHYPIRHGQIENWDHMERFWSHSIFKYLRVEPEDHYFLLTEPTLVRHQPLNPPENRENTAEIFFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSSIKSIPIAGRDITYFVQSLLRDRGEPDSSLKTAQEIKEEYCYVCPDIVNEFAKYDRDRSRFLKHVVTQPGGRQVTVDVGYERFLAPEIFFNPEIYSSDFLTPLPVVVDGVIQSSPIDVRRGLYKNIVLSGGSTLYKDFGRRLQRDIKQLVDARIRQSEMRSGGAKSGGLEVQVVTHKRQRHGPWFGGSLLGSTPEFRSYCHTKAEYQEYGPGIVRRFALLGGPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Q4</accession>
    <name>A0ABR3V7Q4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_3362</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000259">
        <property type="protein sequence ID" value="KAL1837834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="46"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1006"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="709"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1020"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1837834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1136" mass="124373" checksum="55E38DCED9AC6D32" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V856</accession>
    <name>A0ABR3V856_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pep3/Vps18/deep orange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000277">
        <property type="protein sequence ID" value="KAL1837626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="25"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="650"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="10">
        <location>
            <begin position="906"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="868"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111953" checksum="4DDA130B73F75C31" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8H0</accession>
    <name>A0ABR3V8H0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000237">
        <property type="protein sequence ID" value="KAL1838119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="341" mass="38115" checksum="882283BA3A452306" modified="2025-10-08" version="1">MIALLPDSMAAKRSSQTIQPSMTPRYTMPHFVTYGDWDYDALPYDKHWATTHILEPLYEPQPHEMFATAHQPLPTPPSSASPTRASFDHVPREEEASTDPDLDESLVRRILNRSSKTPSSSQEPQPPARPTSKPPTWSQGTILFRPSPPPSPSPTPRGFRKEDPDRDWDRDWWDDHPATINTSRPDVVDALDETGAALYHHEGPFDAALRARNSSPDPRRNPLDALRDSNSEAPPGCVLDAIYRGVPLPGTPGGRDFVGRRGEDEEVVCGGWKRWSYLPYQADDLDRKDLDVFSHPPGRNSDGSRGGGATHRRSVSDGVLLGKRLAQSLRKRWDISLGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V947</accession>
    <name>A0ABR3V947_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000278">
        <property type="protein sequence ID" value="KAL1837618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="42"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="375" mass="42261" checksum="B7742D0D427C05F1" modified="2025-10-08" version="1">MSSNSNHPFTRLISSAMPYKLAIPSMSLGRCAAGHSFINKMDAAKKHGYQGIELAFEDLVGVARELSGEALMPEGPSYNLQLATAAHINAICKARGLEIICLQPLAQYDGLIDHEEHARRLEQVDFWFQLAKVLETDLIQVPASYLPEHLVTEEAELIINDLIEIADMGLRQNPPIRFAYESLCWSTRVSSWEMCWEIVQLVNRPNFGMVLDTFNIAGLVYADPTVASGLAFQAEFNMRQSISRLVESINVKKVFYVQIVDAERLDEPLVPGHPFYNPEQRPRMSWSRNCRLFYGETDRGAYLPITDIAWAIFHGIGYEGWVSLELFNRRMEDKDPAVPEELAKRGAVSWAKLQKDMGLETGKVRAIVTRVVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9J8</accession>
    <name>A0ABR3V9J8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein root UVB sensitive/RUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="35"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="451" mass="49856" checksum="2A5D246AA1D2278B" modified="2025-10-08" version="1">MSRTFYDIDPAGEVLCTYTESGEREALTAEKTEVPLPKAVLYAFLPAGFPHSVTEDYLAYQTYDSLQAFASSITSLLANRAVLEGLGVGDSSSSPTGALILKITGDTISRIATILFAHRMGRAIEPECKFYRFLADIFNDSAQFLDLLTPALPYLPKLGVIVSAGVLRSLCGVAANASKASLSAHFALTGNLAELNAKEASQETVVSLLGMLVGSLVVRLVEDKQLVWALMVLLAGVHLAMNYRAVCSVRMRSLNRQRATIVFRAWLDRGAVLTPADVARRESILWHSRGDLSSKSGDYRGFCDFCTYGDLRAWNPRGYHRYDFETPAYFMGIWHRGGYFYMRIAMKEGCHESRGPLAAWFDAVNHAYHFDSALKDGLQSHYENEMPLGYVSDEQKETLFAALTAAGWDLDINAVETRLPVRVRVGDGKKLLHVSEKDPLRPSGVHEPKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Y7</accession>
    <name>A0ABR3V9Y7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000202">
        <property type="protein sequence ID" value="KAL1838649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045833480" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="151"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="325" mass="35106" checksum="6253D46D67D93CEB" modified="2025-10-08" version="1">MKTSAFLAACGAVLCAAGPIIQPRKVYTKTDVVIHWVTVTVTEGDIVTAFHRPNPHPKPATTTTEEEEVSTPTPDPSPEPASSSEEVVPPPPETSQEPEPTPEPQPQPQPQPDPQPQPQPDPQPQPQPDPQPQPQEPQPSPQPETPQQPTDYIGAALHHHNIHRSNHSAAGLSWSDDLANSAAVLAQRCVFAHDTSINGGGYGQNLAMWASSSQQQIQSFGATKSLAKATTNGWYNGELHLFASEFGKANPDKTRFREWGHFTQLVWKDTKQVGCATHLCPPGTITSGMSSWYTVCNYYPPGNVGGQFDKNVLPPQGQATVFAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAD9</accession>
    <name>A0ABR3VAD9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000192">
        <property type="protein sequence ID" value="KAL1838799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF7">
        <property type="entry name" value="ACYLTRANSFERASE MBTK_IUCB-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="2">
        <location>
            <begin position="296"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="466" mass="50870" checksum="77DA0C52707871DE" modified="2025-10-08" version="1">MVSPTRPPRSFAAYAASSDPILKLPHPYQIAYHVQQQSTAADGTGWYHLVARDAEQQPAKCRPPLPESLLSTAALTFIEPADLPSSARPADANNTPWARARRNPAVTVRWSQGGNAAPTVAQLWLLVYAVFTVRPAEEAFRLHLDDAAGTSAKDRLARQLMAVGLAVPHPAAPTPPAGAAAAAAAAAADGETAGELLISRSAFWQGAGSPFGPRPAWAPEQHDADLIGLDLSTYPLPPPEYVASVAQSSSSLSAGPTDGTAKGALVWHPRRRAKPAPGSVLYSRWIPHLRETFSMVALDVRDETHVDLFHAWQNDPRVSQGWNLTGSREQHVEYLKRVDEDAHQVAVLARFDETYFAYFEVYWAKEDPIGAYYLAGDYDRGRHSLVGDVRYRGPHRVSAWWSSLMHYLFLDDPRTGSVVGEPKYTNTPVLMYDLIHGFGLEKFIDLPHKRSALVMGGTGLGLVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAE3</accession>
    <name>A0ABR3VAE3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000200">
        <property type="protein sequence ID" value="KAL1838672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047208428" description="P/Homo B domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="11">
        <location>
            <begin position="478"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="637"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="753"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="642"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="853"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="873" mass="95238" checksum="12F33DB61A1759A4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAE6</accession>
    <name>A0ABR3VAE6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000216">
        <property type="protein sequence ID" value="KAL1838406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045554993" evidence="1">
        <location>
            <begin position="25"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="325" mass="34698" checksum="B4F1BC1BA7CED9D5" modified="2025-10-08" version="1">MRAQLQSLVLVTIAALLLPSGAWAARPCTGETVNFEYRLGDVRYDGPDPSKNNGLATIAASLQTSTGTPVFECVAQWPEQWAGWFEGDNKPVWADCIFTGAADAQDDTVSFAVDWKTKTIYLVHTFGCSDKPGSVGLATGSITLDVTCITSDDNSYCVPEAPEGAVRPTLNIQTKLRQVPTGPASACDEAYSLYHGWVVEGWLREIEMLPGAVPTTPNIVFDSGPSFQIKNVASGDMLSCSSAGKVNGTFAGACEAVDEESSTNAEFQFDTELNMLEITQRWTCGGGKALGIQGVGYMQGSCGRILGTDRFRCTSLPVWFGTGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAG0</accession>
    <name>A0ABR3VAG0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000199">
        <property type="protein sequence ID" value="KAL1838687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="132"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="711" mass="78665" checksum="338F8F0FC9B2EDD2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000187">
        <property type="protein sequence ID" value="KAL1838890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="451"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="288"/>
            <end position="308"/>
        </location>
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            <end position="475"/>
        </location>
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            <end position="67"/>
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            <begin position="138"/>
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        </location>
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            <end position="187"/>
        </location>
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        </location>
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        </location>
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        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="507" mass="56032" checksum="1DE34CD0A0E6FD1B" modified="2025-10-08" version="1">MASRFSAARPKRASEAYARAHHGGADRDDDDDGPGTSKRVKFDLRNPSALAPGQGDDDEDEPDDVLDADVIGAAVRGTKRGAVNIDGYDSDSENENFEARAEARSRGRRRGKDAEDVDLAEVMDHYDPKAPLGGGKEDEVDEEVDMFGDMDDDKEERAADSKHSGLKKDKQVRFLSDKDIEGQELDSKSGGTVRLDDRPDDASSASDDEEEPDDAAIAAAMEEEGIDEEVGRGGLKKHAPKIDAFNMKAEQEEGAFDEAGNYIRKAADADAVHDRWLEGISKKEMKKAAAAHERREAELRRQQRENDSVRTGDLFRDLILRLEPGETALDALARLRRSQTKPNKTKKVPKWKQKKANKKANGDGGGGGEAMDVDPAAPAEKEPEDPKQVKIKEAINAIADAADKLLQRDFPNVYDMERERLVREYRNETGEAWVEPPERPDEDDEDGMGQPKMWEFRWTDGRDGGAKQGPFDGPTMKAWQNAGYFGEGVEFRPAGEEGGWTRVASFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB22</accession>
    <name>A0ABR3VB22_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">VTJ49DRAFT_2075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
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        <lineage>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000186">
        <property type="protein sequence ID" value="KAL1838911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="63405" checksum="1778CE4BE55278AE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB24</accession>
    <name>A0ABR3VB24_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000185">
        <property type="protein sequence ID" value="KAL1838918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="401" mass="45840" checksum="E0D72F403BD3A376" modified="2025-10-08" version="1">MLRTYRSFRSLLGSARLSARWKNGQTIRIERVKIRKAKPVSRLFGNVIKGALVFQLLLWTLLPLPESDEESKHDPHTEPRFIPFPFTTKTRPPEYYSGSSPEWQEFVRISKDPNTQQEILKLAAEYVLKTATTSQNLKGQNVGSDFRIRRYWLDIYYPYMAPPEFERSGILVKADSLEWTTMPIDHSLILRLERVLWPQPLAMGVWAMGTEAFKQASRQVAKYFSFDAHEANNPPARSGSTPELFGSRSTPEVQKALERLRQQATRRPEQVNDPRSMASSSSTSTASSEPSTPRDTSGAIADPNRKKQDDKPWIESVGLSVANSQAWRRFRETFAQNRRTKLLNPPRGSLAVQGLVELETSRAYLVVETMTWYDPKTKSLVPESTRMLLKGRKLKVQSPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB48</accession>
    <name>A0ABR3VB48_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2484</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000204">
        <property type="protein sequence ID" value="KAL1838616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="12">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="200"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="540" mass="61793" checksum="9C612610B4DBBCB6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBX3</accession>
    <name>A0ABR3VBX3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methionine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000181">
        <property type="protein sequence ID" value="KAL1838997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="675" mass="75506" checksum="35508CB4D5880C92" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC13</accession>
    <name>A0ABR3VC13_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000164">
        <property type="protein sequence ID" value="KAL1839322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="899" mass="97915" checksum="AC5001AFCE2F51EB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC72</accession>
    <name>A0ABR3VC72_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000168">
        <property type="protein sequence ID" value="KAL1839230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="247" mass="27582" checksum="C4C2AF9E1679E999" modified="2025-10-08" version="1">MSESDFSLDVEESTTPNPDPADPLATHEAALTVLEDDYDNAGMQTRLPLKGLIGFLGSIRRRKPRLAENLAALESEIQELEMTFSVPENAQERIAKYKQDEQEFEEMRPMFRETQEELNAHLTSIEQSMPENERSSFPAAVTIMREANNAAAAEIDALLVALVEKNAKLRAGLEELVWMWSKSEDEDQDKGSQGSVSGKVGEKADDEGSTSSEVERVDEPPQAEWGFWGIVKTAQSFTTNLLWEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCB3</accession>
    <name>A0ABR3VCB3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000162">
        <property type="protein sequence ID" value="KAL1839344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="267" mass="29005" checksum="E693BA7B5A8D875A" modified="2025-10-08" version="1">MMSSTNEEDPFLQVQQDVQTQLSTARSLFNSYLRIRSLVAPTSSSSPELASARADLESALSNLSEDLADLDASVRAAEPDPARFGLAPAEVARRRRFVNEVGGEVADMREELAKSPSAASGSTTSTVGRRAAAPSTGRSDLLDPSSFAMPGDDSNNGTNNNGVDYAAEFEHQQQLLLMREQDQQLDGVAQTVVTLRQQADDMGRELGEQLGMLEVVDELTTRVGGRLQTGMEKLKYVMRRNEDRLSSCCIGVLIVVLMILLILLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCH6</accession>
    <name>A0ABR3VCH6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000153">
        <property type="protein sequence ID" value="KAL1839510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="687" mass="77055" checksum="957F2EA224CD34F0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCM0</accession>
    <name>A0ABR3VCM0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="360" mass="40938" checksum="E97F4359CC1F651D" modified="2025-10-08" version="1">MPPKKNEKGGKKPDVKKIVEDKTFGMKNKKGAVAKKMIAQLQSSASANAESKRREAERAAREREKKAAEEAKREAEMLLNKPAQVQKVPFGVDPKTVVCIFYKKGNCEKGKKCKFAHDLEVERKVEKKNVYQDTRAEDEEKKRQETSADWDEEKLRSVVLSKKGNQRTTTDKVCKYFIQAIEDGKYGWFWVCPNNGDKCMYKHALPPGFVLKTKEQRAAEKALMDKSPLKTLTLEEFLESERHKLTGKLTPVTPETFAKWKKERLDKKQAEEQLRKAKEATGRALFESGNWKMEDESEDEDDDSDAWNLEKLRRETEALRIKKEEERLAALHGLPPPSAAADANDAEPGAVAEPEATPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCQ7</accession>
    <name>A0ABR3VCQ7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045798585" evidence="2">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="321" mass="36060" checksum="BD33F1AED809B25C" modified="2025-10-08" version="1">MKLQSLLFSGLLAGTASAIGPRGPPERLEGKPEKMANWRWANPFASPHISKFDVTCEAEKTFYAREYMLDDLALSAPQGLIVYRDALRSVFSKRQYPGSWDGIDPHGYDRLLLTMAYAEMPLRVREWIEEQERKDGQGKGLFAVYAAPSIPGARVLNTIKVPEETPVSEEWRARDERRIALFAPGALYEILPLFVADESGCEDLFGDLSKYSHKLLDGGVVAYPVNHTTPDRSQGFRDIEITIKAQVLKLKEGEEAPPNDPPEIDASQKEEEKKEKSKEEEKAETKTEEAKTESTEKAEKAEEAKTEEAAEKPKSDEKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCV2</accession>
    <name>A0ABR3VCV2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000152">
        <property type="protein sequence ID" value="KAL1839527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="40"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="516" mass="57649" checksum="DEC68A9C00F1A236" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCW3</accession>
    <name>A0ABR3VCW3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000151">
        <property type="protein sequence ID" value="KAL1839539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="167"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="436" mass="49157" checksum="255FFF285E2E3902" modified="2025-10-08" version="1">MLSGILIFNQKGENLIFRAFRNDCRPRLADVFRIQVISNAQVRSPILTLGSTTFSHVKHENIYLVAITKSNANAALVFEFLYRLIQLGRSYFGKFDEEAVKNNFVLVYELLDEIIDFGYPQNTETDTLKMYITTEGVKSERPEESAKITMQATGALSWRKADVKYRKNEAFVDVIEDVNLLMSATGAVLRADVTGQIIMRAYLSGTPECKFGLNDRLLLDNDGLLSLPSGNKMGSKATKAAAGSVTLEDCQFHQCVKLGKFDSDRIISFIPPDGEFELMRYRATENVNLPFKVHAIVNEVGKTKVEYSIGVRANFGSKLFATNVIVRIPTPLNTARITERCTQGKAKYEPSENNIIWKIGRFPGQSEFVLSAEAELTSMTNQKAWSRPPLSMSFSLLMFTSSGLLVRYLKVFEKSNYSSVKWVRYMTRAGSYEIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD49</accession>
    <name>A0ABR3VD49_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000150">
        <property type="protein sequence ID" value="KAL1839560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="551" mass="59926" checksum="7CC113AB00E6193C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD74</accession>
    <name>A0ABR3VD74_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Suppressor of anucleate metulae protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_1619</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000162">
        <property type="protein sequence ID" value="KAL1839351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="570"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1162"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1839351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1284" mass="141226" checksum="84E99A079DEDFF8F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD94</accession>
    <name>A0ABR3VD94_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="JAZGSY010000138">
        <property type="protein sequence ID" value="KAL1839844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044968544" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="349" mass="39344" checksum="9B2A6511B4F0FB3D" modified="2025-10-08" version="1">MRLNLSTLLLSLAASADALQYKGVDWSSVIVEERAGVRYKDVNGREKPLEQILVESGVNTVRQRVWVNPWDGNYNLDYNIQLARRAKAAGLDVYVNFHYSDTWADPAHQTTPAGWPNNIGDLAWKLYNYTLDASNRFADAGIQPTIISIGNEITQGLLWPLGKTNNFGNIARLLHSAAWGIKDSRLNPKPKIMVHLDNGWNWDTQNWWYTNVLNQGSFLMSDFDMMGVSFYPFYSDRASLESLRSSLNNMVSRWGKEVAVVETNWPTSCPYPRYSFPADVRNLPFSAAGQVEYITRVANVVSSVNRAVGLFYWEPAWIHNANLGSSCADNTMFTPQGQALSSLSVFQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDE5</accession>
    <name>A0ABR3VDE5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="304" mass="33592" checksum="B66F53495E8555BD" modified="2025-10-08" version="1">MGKKRSREADGQGDLPMEDPAIQRKSDDDDDDSSDEDMDIVNVDFELFNYDPQIDFHGVKTLLRQLFDADAQLLDLSALSDLIVEQNTIGSTCKVDDKANDAYAFLTVLNLTEHAPKKPAVAKLAAYLAERAQGDEGLAASGVPELLSNPGKKQVGLVLAERLLNMPAEVIPPMWSCLIDEIEAAVEDGEPYQFTHYLVVSRGYHEVESTLDQSERKQKKAREEAELQYFHPEDEELRRHAASSGAYPFAREGEVVADSRRAFQELGVKPCGLMMLIEAGKFQRAVQAMAEYVGTGGMTMSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDN6</accession>
    <name>A0ABR3VDN6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_1106</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000139">
        <property type="protein sequence ID" value="KAL1839827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="393"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="799"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1839827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="855" mass="92147" checksum="298C9582C407FBBD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VED5</accession>
    <name>A0ABR3VED5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome-interacting GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000127">
        <property type="protein sequence ID" value="KAL1840094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="65"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="291"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40382" checksum="E6A8B5991F584934" modified="2025-10-08" version="1">MATTIDKIKEIEAEMARTQKNKATSYHIGQLKAKLAKLKRELLTPSGGGGGGGGAGFDVARTGVASIGFIGFPSVGKSTLMSLLTGQHSEAAAYEFTTLTSVPGQVTYNGAPLQIIDLPGIIEGAKDGRGRGRQVIAVAKTCHLILIVLDVNKPLTDKRIIEAELEGFGIRLNKEPPNITFRKKDKGGLNITSTVPLTHIDHDEIKAVMSEYRISSADIAIRCDATIDDLIDVLEAKNRAYIPAIYVLNKIDSITIEELDLLYRIPNSVPISSEHAWNIDELMEMIWEKLNLVRVYTKPKGKMPDYDAPVVLRSNKCTVEDFCNAIHRSIVEQFKTAVVYGKSVKHQPQRVGLAHELADEDIVTIIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEG8</accession>
    <name>A0ABR3VEG8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="181" mass="19953" checksum="ECAC91B515347FCF" modified="2025-10-08" version="1">MNLGHPKRCCHPSGVRAERGEVAETRTSPDFRQAARGLVIGTHVIGSWCYSNVPFCRSRPPALRVLYADSGRPLDYTISSNNLSLPNGVAAEAASLPGSWLDNPSCFDDPSERHFEGEAISTYHRSHWMSLPTRRQLPAMPDLKKGDPRPRRKFTGAPACMAAGEAAIHPLTHQATNRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEH9</accession>
    <name>A0ABR3VEH9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="811"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1932"/>
            <end position="2007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2128" mass="230878" checksum="5B93F82E0720CC40" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEP6</accession>
    <name>A0ABR3VEP6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="41005" checksum="8DF2727FD4EFF1B7" modified="2025-10-08" version="1">MVVSGLRLGMDAPDSALVAAAGMADTPSAPSAPSVHDIVQENHDTEDNYLDDVRPRHADDHTSPCAAGDHDASAQADPAPDHPAAGSHSHHTAAASRAGSGSRPGPSGVVNAFDPSASTPPSSDKNAIDSSNGSNAGPGESKGSGGLSPGATAGLVVALILLLLLIFFAFRYRRRLRDAVSKFRGSRFDRIETPGPDNMGRQLITPVPPAGSPPPAGPSSAPPSQQPQQKPSAPPPMRQHGAPNTLLIPAAAARRDSNRVSIFSDTSTNTAGFTPSPVSPASSINNMNMGGNMHIAGAMLSPGAVHSSRPVQEPPDPRAARAQPHHVSRGSVSTISTVSAISAALSPGQMAWPMPPGTPPAIKHPDGGAAYIDFERQGETVVKITQPKRSHHHQRSGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF51</accession>
    <name>A0ABR3VF51_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000113">
        <property type="protein sequence ID" value="KAL1840432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF1">
        <property type="entry name" value="FILAMENT ORGANIZATION PROTEIN APP1-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="341"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="434"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="65882" checksum="6D4E27013C749D6E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF93</accession>
    <name>A0ABR3VF93_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000128">
        <property type="protein sequence ID" value="KAL1840086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="3">
        <location>
            <begin position="40"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="379" mass="42373" checksum="C45B261EE64C79A8" modified="2025-10-08" version="1">MQRPSCTAPPQSVHSFPSSSATQLTIVDDDPTMVIRRSPREEIAIAQTVLFSISLLYAIYCKFTHRNGWFCIGLFSAIRVTGAGLMLGPLNRRGIRVGVFICESLGMVLLVFLILEFLDRVNKHVRVIHPRWFFFPQLLTWADLALAIAGFATGSRDPDNPLAPTKFTQASYGIFTGLYAIVVYVAWRLHRNLGGSMRPHHPSLSGTSPGTVAATTTTRMPNLSRWWRSLRPRHPSHPASIIRPVTAGSDSAAAEEEDDYVAYENRVLVYVSIVSLVLLALRMTYGLLYQFDTKVDTWSPLDGDWIAYLFMQFFPEVGMVYLGGWAVWMVSPPPRKKMSGWKRTRDGERDVERGYELVGEGSGDGQDRRGNDGVGLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFI7</accession>
    <name>A0ABR3VFI7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="275" mass="30520" checksum="2C719B0F7BACAEC1" modified="2025-10-08" version="1">MPPGRFERTEPAGGDRGAGEEWDSRHEIDERPEDEVFNGGHLGDRGDLPGNSEHSVGTSNPSYQSIFDIADNPVNLDILPRADGDVLFPQGKTSNEISRHRTDAMQKSNSNFTFNKVVSNLKSRHETLDTQRVIAKGQLSYFKDIKLEDFKPRQCQVETSDGLVTIGDVTMDGEAPPDANAFMKFYGTVGKIRFPNETIATNRGGSSHRVKSPEELASLSKMEMEENRAKRLKITIEALRVAENAADAEINRSAKKSRDLIAKMEQGGEVVQWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFK3</accession>
    <name>A0ABR3VFK3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047049733" evidence="2">
        <location>
            <begin position="19"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="328" mass="36124" checksum="3CE08C6F91428DBA" modified="2025-10-08" version="1">MLWTRTLALAALAMGAQADSLVSMLKENLSKRDSGAQERQLKEAAKVILRSRGFLEARQSTGTNTPGLNPDGTLDMTAWNDAANRACQDALRTLEVASNPSGACVCYNLPILNNVTGFFEADLRLYQLSEPREQFLGIPQEKIEVELSYNGATVSEVKQQSVAGLKARQAPQEQPRTDLRLLRSYLFVGQVDKDRMTDDMTPGVLQSFIMPVVTLKAINNNGLIVSTNVSSNEAAFVVGEFSTQVFMSSFRQAELAIEAELEKLKNGTVAFVLPGVELMIAPWGLAITSLWLVLGLGAYGFGTYERYNFRELHRKRVAIQEKGAMPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG32</accession>
    <name>A0ABR3VG32_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Required for respiratory growth protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000108">
        <property type="protein sequence ID" value="KAL1840550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29775" checksum="67C21894F7B30DC4" modified="2025-10-08" version="1">MRAVFLRRPVPFRLPLPISPLRRTFASASPEVNPESTPNAHNSPQPQPQPPPEQPPLIYPNPASAPHHTGLPSFLAYAERTNLDPSSTVYVGTHFEYTVQLALARFGLDLRRVGGASDCGIDLLGTWALPFPSSHSSSLSGAAAALSPLRVLAQCKAVQRPGPHFIRELEGAFVGAPAGWRAWTESGRGGGILGLLVAEKPATKGIREALARSRWPMGFVACSRVGEVSQFLWNRRAEEEGLEGFGVAVRYVDGDSGGKKEVVLTWKGERVSSVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGA7</accession>
    <name>A0ABR3VGA7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="373" mass="40238" checksum="C1D94D9CFDEFA7F8" modified="2025-10-08" version="1">MAPSAQAHKRAHSLLLFDKLLSLRDSASPLTIILDTLEQSARPLTHEFMRRAKAERAKIIFVSYATIKKPAVADVFVKARGKTLKALAEEIASHAAPTRPSSSSDPSQPPGQKSLILIDTLNPLTLTTPHLLPAFFSTIIPTPTTSLVAVYHADVPSTIPTPSLHGHAAGYAPDPLALLTHLATAILRVSSLHHAIEARRAKERSLPEPEWGLREGREGREGVLVGLRSLRGTGKKGVGYGGKDGGGGDVVGGEEEEEEVVVDMEMRRRSGRAVVERFVLVAGKGRKKGGGGLTAMLLADHPEFKVAEPEAGVGEDEMETTFDLGLTEKQRKDREGVVLPYFDAQVEVGGGEGGRILYEMGREDDFDEEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGC2</accession>
    <name>A0ABR3VGC2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alkaline phytoceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50805" checksum="504C91A0E268A872" modified="2025-10-08" version="1">MGLVSALQIPYRESREGFWGDQTSTLNWCEEDYNISFYCAEVVNTLTNLVFMWLGLRGLRDVISFGHSRVFILVFLGYMVVGLGSMAFHTTLKYEMQLADELPMIYTVCIMAFATFGYKRAPKVQALIATGLVGLAVFITVYYLYAQDPVFHQVAYGLLTLSTVCRGFYVMERHVRPRLKQRNPAEVEWYMRNMYKLAVSGIGMFLAGFFIWNIDNIFCHHLTASKNRILLPWSVLLEGHGWWHILTGLAYHMILWRVWLNRCLDGKETEFMLDWVPLRSVPRVVPRVGGAVQGNGFRKTQARLILNPGIPNPPGQHLSRKNTVTQPKMSISNEALQKLVREIESQAVAAQQQISLVRTQVAAKQREMRLAQLTRNEIAALPADTAVYEGVGKMFVAVPVPAMQDKLGSQIKEIEAEVDGLGKRLHYLETTAKNSQEHIKKMLKGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGF9</accession>
    <name>A0ABR3VGF9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000106">
        <property type="protein sequence ID" value="KAL1840602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="4">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="181" mass="20206" checksum="35BE6B41B6B966D0" modified="2025-10-08" version="1">MEPPRPEEGNAAQDVTEADLITQRSRWATRKLTVKSSAVKRLSLRGRGHHKNSSIEKKRVSGGTDISKPPNGSNDHGATEEQQRQDENHDGPGPRELYFGLPLPRELQDDDGEPIQQFTRNKIRTAKYTPLSFIPKNLFFQFQNVANIFFLFLVILVVSPPGTPPFCSSPANTRADNALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH09</accession>
    <name>A0ABR3VH09_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000085">
        <property type="protein sequence ID" value="KAL1841140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="65"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="231" mass="25267" checksum="CFE7775B682C4F05" modified="2025-10-08" version="1">MVSSSIRKQSPDTEPPVKKSRPSKQSTAAKSSVVGVNSVDVKEKGANVAATPVIDGGAPSAGERNYWLMKAEPESRFENGVDVKFSIDDLAAKTEPEPWDGIRAYAARNNLRAMKKGDLAFFYHSNCKEPGIVGTMEIVQEHSPDLSAHDPKAPYYDPTSSPSNPKWSVVHVKFRSKFAVPIGLKELREMGGPGKPLENMQMLKQSRLSVSKVTAAEWEYLMSMAESKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH82</accession>
    <name>A0ABR3VH82_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="584" mass="64008" checksum="C57050CF3FC6C8CC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHD0</accession>
    <name>A0ABR3VHD0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000080">
        <property type="protein sequence ID" value="KAL1841284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="431" mass="46610" checksum="D788D2E863E4F1D9" modified="2025-10-08" version="1">MPAAMEANIPLPDIRSVVNPVLQCLPGAAVSTEPPTSVLPALSPVLRQRAQFLSSASMEPWIRLLSYEPAKVPQLTNLARSGDLDPHPVSGEVELDWDRAARVTYKRIDEETLQGTVLLKEFGLFFRLVWCINDPDGGNGWRVGEVGVSDSTAFTNFGGYPSITEAETSFKTAKSKPSTNGNLAANRPQPWNHTAHDDDNGDDDDDDDYWARYDATPSRTPAVNRSPAPRTGAASQPAPSAAVHTSNPTNTADEDAYFAQYDSVQPAMDNHDPDEEANVREHAADLLEPLRPKDPASFLTNGITAAEREATSPTTRHHNPDLAHPIPTRSSSGSRGNRSRSRSQEQEDGESSWVMAPAHPRRASASSSSAASETVAKLESVAESRQQAEFGADIKKVRAKSRQRSSDDKAGADDHNDHADGKPPRSQSGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHF5</accession>
    <name>A0ABR3VHF5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="417" mass="47059" checksum="AD2A89AE32DAE88C" modified="2025-10-08" version="1">MTPLSVTLGAPTAQQNARPISMAPHSDKPPASGPPPPPTDHVKPIGPPSGILAIPSQWNSEQGLQQSLKQIGWDEKREDGHRLKGVQLIDAVRQSLHLPVKTFDTAAVYYHKFRVRFPSSDYNYEDVALAALFVACKAEDTIKKSREILCAAHGLRQPHDHKTPDDKIFEAPSRFIIGLERHILETVGFDFRVQYPQKLLIKMVRKMFPRDDPASQTEGKEFLRVAYNMSIDMYKTFAPIKQTTFTMVLAILELTARLLDTDPQRTKQFQDASSWHSNRDCVVETILDLLDLYTRFQKSTKVGVRFDLQKLMDVKIDFNNLLATEKRERYTGWCDRCGPDTADTRSATPGSATSPATNPSLPGSNPPAKRKMPPTEGTQRFIFDADKAREERDIVARYFNDEYEDPIEARVLGSMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHH3</accession>
    <name>A0ABR3VHH3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046185333" description="CBM1 domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="9">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="325" mass="34070" checksum="E8F8FCEF0307610C" modified="2025-10-08" version="1">MLSLSTLAVAAFAAVGANATPAVVARQATPTVYLAGDSTMARTSGQLMGWGEYLSRYITLPVVNKAISGRSARSFTNEGRFAEIERLVRRDDIVVISFGHNDGGSPNNANDNGRSACGGTGNEVCRSGKTGELVYTFNYYIENAARSFIAKGARVVISSQTPNNLWDGGTYWDGAPPRFVPYAAQAARNVGNGASFVDHYQAVANMFRRLGNQGTNALYPVDHKHTSPAGADLVCQAFVQAVALNLNGTTPLAQYVKQPVPNVFPVAGGSQPSNPPTNGGGNNGGGNGATAPLWGQCGGNGWSGPTRCAQGTCRAQNEWYSQCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHR0</accession>
    <name>A0ABR3VHR0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="210"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="319" mass="35116" checksum="1403486B1D0EC432" modified="2025-10-08" version="1">MAQKCVHQGCGKTFTDPDEVCRYHPGPPIFHEGQKGWKCCKPRVLTFEEFMTIEPCTEGKHSTTDLPPQIEKKEADPALLASATSSNLPPPPPRAPITAPQHIPTPPPPPPESEDDDESIEIPDGRICRRKGCGAVYKKGASREGEKCVHHPGAPIFHEGSKGYSCCKRRVLEFDQFMKIEGCKTKDRHLFVGSGKKEAAAKANGGEELLETVRTDFYQTPTAVIASFFLKKINKDEAKVEFLEREIVLDLPTTDTPVKRYKTRVPLFAAVDPAKSSFKVLGTKLEVSLAKADGASWPVLRSDDRLTGEILQVGRAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI78</accession>
    <name>A0ABR3VI78_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="670" mass="72346" checksum="58B0ABB9EFE188B1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIR2</accession>
    <name>A0ABR3VIR2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6663</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1253"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1286"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1325"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1365"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1396"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1522"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="218"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="912"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="863"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="888"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1583" mass="175747" checksum="C795880CDBD364A3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIR5</accession>
    <name>A0ABR3VIR5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1841684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="649" mass="72311" checksum="17D7082FEC204BCC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJU5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_6071</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="137" mass="14152" checksum="E06066A688FDFCBD" modified="2025-10-08" version="1">MPLIPVSTDAIHISMTVPSSAPPPGLPDMSSRGPIGTVTVAGVVFAVACQAASAGMSFGVTSGTGRQEMHGWMVKRRCEGIPARWKTASASCTPKVRISARRVALIMTATMATATITAAAVTASGSQRDTTYYIVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJW8</accession>
    <name>A0ABR3VJW8_HUMIN</name>
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        <recommendedName>
            <fullName evidence="9">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000051">
        <property type="protein sequence ID" value="KAL1842190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="285"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="760"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="858"/>
            <end position="889"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="257"/>
            <end position="275"/>
        </location>
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            <end position="596"/>
        </location>
    </feature>
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            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
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            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
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        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1216" mass="131858" checksum="8F4C6A1750BFF9CC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK65</accession>
    <name>A0ABR3VK65_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="211" mass="22998" checksum="060B022EB618F02B" modified="2025-10-08" version="1">MTSMTYLYSQDQHGHLVPYMAALHASCISLDGMVGPFLPPLTNEKLLPWWRERIAEANRGTRIIVLLLAPPSEATPTPPATPGNGISITNSAATAKKPLGTDLRGLAMLKLSESETGSFRGRIDTVLVDRRHRRQGGARALVAALEYEAAKRGRSLLLVNAETDSVAETVFKKLGYVEIGKVPHFSRALPTGKKKGETFFYKEFLPAPQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK73</accession>
    <name>A0ABR3VK73_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_7251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000080">
        <property type="protein sequence ID" value="KAL1841306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="226"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="394"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1841306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="492" mass="52500" checksum="C5794B9190AA9489" modified="2025-10-08" version="1">MTLENPSSGLGLACCSVTAVLCVTLQYSTRHTARPGTAVMPSLRDDTVAAYTDASPGRSIPTITTTRPSISADDYDNDNDSLFSSDDDTNNLNRHNPNPRPAWTPRPTPPGARRLSSRRSSSIHSSHRTTSLTTTAKSLLTTLSQALTSLLRHLLRLYLSLTPLQRILAFFASGILTTLAVLFLIYSHRVFAALGPLAASWRAAPFGWLPIWLATTATAFPPIVGYSTCVTAAGFVYGFPLGWPVAASATVCGSAAAFVASRGVLAGYVQRLVGRDRRFVALGQVLRKDGIGVLVMVRLCPLPYSLSNGFLGTVGRVGLGRFVLATAAATPKLLIHVFIGSRLALLADSGDVMSGLDRFVNYASMVVFGLLGFFVGLLIYRRTMARAEELAAGRGDLDEDGEIDPSRLEAGDPFLDGRRGGMGDEETVLDDDGDSENGRMVHPDDLDAAAIMDDDDISLWDTHGDGYHDSWDDDEGTTGNGNGVNGSGGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK90</accession>
    <name>A0ABR3VK90_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="83335" checksum="5654EB22C4A8F8B6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKA7</accession>
    <name>A0ABR3VKA7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="407"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="510"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="692" mass="73683" checksum="DD608FB771C0CFE7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLI4</accession>
    <name>A0ABR3VLI4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_4846</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="16">
        <location>
            <begin position="128"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1842563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="353" mass="39954" checksum="C43947B7E02E7AFF" modified="2025-10-08" version="1">MSLSRSTSPIPGGGWATPGLDITGGRSSPTRALSGTPAMWQQSSRLGRNHGGGGYGGGSNHNNRYPSFSTRTQGFFGRHMRRLSNSLPRFNSSPYYADKEKLGRERWSAQNATLPGRIRSILGRMGRKMKTRLLFLLILLSLLVFFNSPFVYWWRRSSWFGGGEKFVIVIGANYFAYNFRAMGSLQDIFGQLWKEYSLSDSRYLTKSAPVLCIEALTAIFWGPLSFLIAYFITTDHPLRHPLTILVSSGQLYGTVLYYATAIFDETIYGKTYSRPEAYYFYGYYVLMNSFWIVIPAAVIFNSFKAWSRTVEALILLDQEVQHGQQRSQSVQYAPQVPQVQYTGSQQVKAKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLR1</accession>
    <name>A0ABR3VLR1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="219"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="447" mass="50029" checksum="92BAEC0CCB0E8C45" modified="2025-10-08" version="1">MDQNLQAFFTMVENQDGVIVRDPPKLDLEIYIQNYKGRTRFDRLFLIGRSSVPLCVEALKAAIAEAKRGKDTHRYREAVELLRVAAPSEPEATYDQAWLEAQEASNKAETNRLLTELKGYKNNLIKESIRMGHEDLGKHMESIGDLNAAAEAYSKMRPDISTPKQFLDVGKHLVRVSIQRQEWGMVATHVGKLQYVEEDKTVEGYMKVSYGIALLGQEKYKDAASSFLAADPAIPASSYNELASPSDVAVYGGLLALASMDRDELQSSVLDNSRFRTFLEQAPHIRRAVTQFVSGRYSACISILESYRPDYLLDLYLQKHIPAIYSQIRSKCIVQYLIPFSCVSLETMEKAFGRPGQSIEDELADMIQLGALQARIDSINKLVTTRTSNPRSQMQAAALKAAENYERQALDRLRRIGLAAADLELKGGKKMGGFAAQHDFMVEETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLS1</accession>
    <name>A0ABR3VLS1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1751"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="1796"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="148"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="242"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2001"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2091"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2137"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2020"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2048"/>
            <end position="2062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1843143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2203" mass="247289" checksum="359E95B389854E90" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMX1</accession>
    <name>A0ABR3VMX1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor RfeD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="162"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31646" checksum="6C7A9E0D23DC8740" modified="2025-10-08" version="1">MQEHIRRAHPEHYIAKLPATEESFLLMISTSPSERPQAQQPATLPPPQAQQQHKQHVPQSAHHAKAAQLDYRRDAASAPGTPRRYEEYTGGALFPAAAALAQLHNHKSDPGWESDGEWHSDSERMRRLRSSVELPPIQLSSADITSAPLPSLESAAGRRDLLPSIMSHSPPGRSSTLPPLHRPLGPHHRARKQSISKKGHHRRKSKGPTSDWLRRIQNDGSSDLLRPGGHHDRKAHSAEPSSDYGKRWEDLIDAAASATEDIDDDRTPRPDAAIACVHPAVVSPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN07</accession>
    <name>A0ABR3VN07_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="540" mass="60340" checksum="FDA609A09430C594" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNA9</accession>
    <name>A0ABR3VNA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_2578</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="14">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="237"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1843247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="297" mass="31547" checksum="277E67E5B70F3641" modified="2025-10-08" version="1">MYRTALRTAPSALRAARPTLASSCRRLASTSTSTSKAPPKKRGSLKGTILRLGLAGAAVYFYNTSPLFADELPSTVGPAPPRFSDEDLPTIDALIEEKRRQAVLAAPPPSPPPKTKPAEPEQAPTPAPTDEENTPKKPAEAEAPKAAAAETEHEPGSPEALEHEATEQGAFNPETGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSKEEPKGMDCIDKFQDMQTCFRKYPEVYGSELADDEEEEGAPAEGGEALAKKEDTKAAEEASAPASAPASKAEASPKETTSKIEAKKTKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNN4</accession>
    <name>A0ABR3VNN4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="143" mass="16012" checksum="DBBD845A1D5B4619" modified="2025-10-08" version="1">MCLGPTSQRASNSASIIPLVKKLFGRPILHKHASTGPDSTSFFSDDYDSPPSNRTEYAWRRSKRLVSRILESTGRPGLGTLAFFVFAVLYIFTNEVSLRAARSVARRLGRLAAKVDEGREEVGEADLKALRGWRWRVVGWSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNN8</accession>
    <name>A0ABR3VNN8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="68"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="178" mass="19530" checksum="F8DEFEAFA19A1856" modified="2025-10-08" version="1">MTVSSTRQDHATDRKPPPHCHSSARYPSANPRGWALQDNKQPVEVDLVTRMQTDESVVGSTEIDESLYSRQLYVLGHEAMKRMIASNVLIVGLKGLGVEIAKNVALAGVKSLTLCDPAPVAISDLSAQFFLRPDDVGKPRDQTTAPRVAELNAYTPVRIHESPRYGQILTSPIRQTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNR0</accession>
    <name>A0ABR3VNR0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="401" mass="44136" checksum="21E8E56BC74B95B7" modified="2025-10-08" version="1">MPRRYLPSNTPRPPSVGNTEAYLTAALEDIVTNFPPRSRYSHDQLHGLWSGPTAVAHLLLHVATRRPDLVVAGRSASDWALRYLADGSRGHNLRLGSRGCGLGDEALAYAAVRAAVTAQPQDIRRLVDYIEQLGLFTCPDDSRGSNSSGSSNEDNYPDEILYGRAGTLYLLRLVRARVRQKGGNADITDPAIAELSNAILSRGPRWRWHGRRYLGAVHGDIGIITQLVLTSPELAPRVQPIVERLLDMQRADGNWPSSEEYAGSVTAGGDKELVQFCHGAPGMVLSLLALRPHFPELHERIDAAVDRARDCIAERGLLTKEPSLCHGILGNALALDPPRREQFLAMATPDNVAKLKLERGVFERADYGRSYSALTSYTPSAVWAWLVWKEDEPAMFAYSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNV8</accession>
    <name>A0ABR3VNV8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Allantoinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="72"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="5">
        <location>
            <begin position="458"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="60167" checksum="71D6CD787FADA097" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP38</accession>
    <name>A0ABR3VP38_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF397">
        <property type="entry name" value="CALPAIN CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="159"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="606"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="650"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="805"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="846"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129412" checksum="BF9E553F8E5DF1F1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP64</accession>
    <name>A0ABR3VP64_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_873</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="859"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="945" mass="105367" checksum="88D73F0EA8ED7F02" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPF2</accession>
    <name>A0ABR3VPF2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="187"/>
            <end position="227"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="564" mass="63814" checksum="5496764ACB794A9B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPQ9</accession>
    <name>A0ABR3VPQ9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="229" mass="24630" checksum="1AFD2B3B0831831D" modified="2025-10-08" version="1">MLKNSISPVAREKARRARERDAKDIASDIIRKALEVGIAPLKLMKLVKSLLRGHGAQSGSSAREESPATDVEDGVEIEQLEAVFKAIAVRARALLAQDGVNDVETPRKQAARGRILGKRKRGAEDPDSEPYPTARDRKRARADYAASSEEGGTQEKAVRGVKLPETPESLKVQDGLRNEEDGAWPADIGEDSGANVEQAKVVVELLVIRAQALLPQDGNVGQTTKTGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ08</accession>
    <name>A0ABR3VQ08_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="594"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="908" mass="98588" checksum="0759F6BA5A1D507D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ18</accession>
    <name>A0ABR3VQ18_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="6">
        <location>
            <begin position="36"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="308"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="659"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="778"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="862"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1075" mass="124066" checksum="83A7171496CE7C36" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQN8</accession>
    <name>A0ABR3VQN8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="375" mass="41371" checksum="6808E5229937917D" modified="2025-10-08" version="1">MRTSNPFSSSVHHANAFPLSKSHAKARPSSTMQSDPVVDEDYVSEEDSDFAPDEAAAEESSVSENEADGDDGESATLVNRKRAAGEAEAEDAGFENSGDEAIIERGKKRQKKSDKKYDGGADDEGANEGPLIKTRRMRAAEKEEKRMQDASGPVTIDVDALWADMINTPVVRKPGAEPPGATPKPSCQQQQHSQPDQKSLAAEEPNLIRIKRTYHFAGKVHTEEKLVPRDSAEAKLYLAENPDADTTPTTDSESDQALKRLPRKAFRSVFEPTPPPDAPGGVTPFTQRRTDLNLCVAERLRAREKAAAEAEARKLNTVEKSRMDWAGFVDREGIRDELELAGKSKHSFATRQEFLARSDMVREEEARRVRMAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR90</accession>
    <name>A0ABR3VR90_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18585" checksum="8774827E9C03AB56" modified="2025-10-08" version="1">MTTTTTTTNPDTQPPTINFILSFLLVGLAWGFTTPFIRRAAKDRAEATAAAAAASASSPTKPYDGTTDDKNATAWWNRLGGLITRGAAAAVDLLRNPRYAVPLVLNLSGSVWFFLLVGKAELSLTVPIVNTVAFLFTVLGEWWVEGKVISRDTMLGMLLSVAGIALCVHSKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRE9</accession>
    <name>A0ABR3VRE9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nicotianamine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nicotianamine synthase (NAS)-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004298">
        <property type="entry name" value="Nicotian_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266:SF12">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03059">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51142">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41125" checksum="40C03EFC0D7877D6" modified="2025-10-08" version="1">MSLFISWLRLGSPTKKMDPCPCASHDSIDIVEKDDILRDQRAEERAVQVQNLVRRIVDTHTDLLRLPHLRPGKIINKLLGDLVTVCSDIYDREVVDAVLSHPGVNAILPSLRQICAQAESCLELHWAEHIVTGGPANPDDVLSRLRSFPYYDNYEELTRLELCAILSATKSTPRRVAFIGSGPLPLTSLCLLQALKRDVQLARLSSPDPTSDSDSVSTPPPDPDPIVLNIDCDASAIAASLTLCLALGDTARGMEFVCAEATAPILPASSTPTENDDDSDSDPAPPTRDLAEFDLVYMAALVGMSQADKERIVRRIAERMRPGALLVARSSWGMRTCLYPEVDLATEGLRDRLECCVVVHPYGQVVNSVIVARVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRG6</accession>
    <name>A0ABR3VRG6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="605"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="704" mass="78406" checksum="918244E20E626990" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRN3</accession>
    <name>A0ABR3VRN3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucanase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF10">
        <property type="entry name" value="GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044997407" description="Glucanase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1844171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="381" mass="41889" checksum="A32D231E3B280B95" modified="2025-10-08" version="1">MRVSSLVAALATGSLVAAAPSPKTPKQDPQGDVNPFEGKSFFVNPEWTGKLDQTAKAFLKRGDLINWAKTLRIQQMSTFVWVSRRSELVNIDNAIEAARKAQKRTGKKQIVGLVLYNLPDRDCSAGESAGELDSTQDGLQLYKDTFVKPYAEKLAAAKDLTFAVVLEPDSLANLVTNMGIELCARAADVYREGIAHAISALQFEHVHLYIDAAHGGWLGWNDNLPLAAQEFATVLKLAGEGKKIRGFATNVSNYNPFNALVRENYTEWSNSWDESHYASSLAPFLESEGLPAHFIVDQGRVHLPGAREEWGEWCNVEPAGFGPKPTTNTNNTVVDALVWIKPGGESDGECGMEGATRAGAWFDEYAQMLVKYADKSIFKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRN6</accession>
    <name>A0ABR3VRN6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="344" mass="35998" checksum="AA6B438DA5590890" modified="2025-10-08" version="1">MDHGYDPRISGATAAVPSRQSNNQSPADAAITAVPSTAGASHYSTLEVAGVPAGDKVVVVNGPEQEKIVIHPAPDFMKEAVPQPYYSLAPGYPVDPNYAQQSYYDTQTSYPMSAWSISNPWGKRTGPDQEQEAPPPGKRETICGLKRRTFFIVLWVVSILVAIGIGVGTGVGVTMRSRSSEDSDAASPSLGAGDSSSSSAATTTTTQPDKTQSPTPSNPADDTPSDIAATPTAVNTGGSRTTISSAGPTSTPQFGGPGGRCVNEWGSDCICLDQGICVNRWRGTPYTGSRGNWPCPDDPDNIMACVVAPCLGREKPASCLWREACREVVPACQYHQSGARAFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0P1</accession>
    <name>A0ABR3V0P1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000719">
        <property type="protein sequence ID" value="KAL1835348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="452" mass="46650" checksum="A50D71B1A88E43D2" modified="2025-10-08" version="1">MASFAAVCRMSARFAARQVRRDATARGLRTSSAALAAQNFTMPALSPTMTEGNIAAWRVKEGEAFQAGDVLLEIETDKATMDVEAQEPGILMKVVQPDGAKGVRVGTRIAVIAEEGDDISSLEIPADEPAAAAEAPKTSQPPAQTPAPAATRTPEPAPSTSSPVSSTPKPSKSGRADPNHTLLPSVIHLLKVNGLDASAASQITGTGPHGRILKGDVLAFLGKIDAAVPRENSARFDKAAHLDLSNIKVAPAPAKPAAKAEPTVSAPPPPPPPQEKLVSVPVSLSAVVETQRKIHDTLGVFLPLSTFIARASDLANDDLPAAPRQPTADELFSQLVGVKSTGTGSAKVSRGDYVPLVGVTAPAGAVMAKTAPVAVKAAKKKADIIDILASASTPASKPKQTSAGGKVVLPGASPSGQNLFSLRVPPAEEKRALTFLQRVKVVLEKEPGRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V150</accession>
    <name>A0ABR3V150_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acetate--CoA ligase</fullName>
            <ecNumber evidence="1">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000740">
        <property type="protein sequence ID" value="KAL1835322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="223" mass="24385" checksum="75037D65D5D2B66A" modified="2025-10-08" version="1">MTDPGSASLPFFGIEPAIVDPVSGEEIHGNDVEGVLAFKQPWPSMARTVWGAHQRFMDTYLNVYKGYYFTGDGAGRDHEGFYWIRGRVDDVVNVSGHRLSTAEIEAALIEHPAIAEAAVVGVADELTGQAVNAFVSIKEGNEPSDALRKDFILQVRRSIGPFAAPKAVYIVPDLPKTRSGKIMRRILRKILAGEEDQLGDISTLSDPSVVEKIIATVHEARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1W9</accession>
    <name>A0ABR3V1W9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000595">
        <property type="protein sequence ID" value="KAL1835592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045439039" evidence="2">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="274" mass="29996" checksum="2B9A1EB19487233F" modified="2025-10-08" version="1">MALALTFLPGTLLACLRAGDLHTLLSLSRLRAAWFARFWARVGPEVRQNAEKNVVPLLQGRVTRGVVPASPGAGDEKGATQPQPHPPVRGTVLEVGPGSGMWVSIFSPASLPGVSKVYGVEPNADVHAALQQRIADAGLAQDGTYEIVPVGIEDLDKSGRVAVGSVDCIVTIMCLCSIPDPKHNITQLYRYLKPGGRWYVYEHVRCFHKQGLAMRLYQSFLNLIWSRIMGGCEMARDTASYLREAGPWSQVDVHPLEGEPWFYTMPHIIGVLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V299</accession>
    <name>A0ABR3V299_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000617">
        <property type="protein sequence ID" value="KAL1835531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF39">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40646" checksum="1C5F2CEE7BD1F5FF" modified="2025-10-08" version="1">MMRIAGQAPPLSGFGIPALPAVPRETEPIATAPSMEPGDSDLHQQQPTMNSMSTTFLSPGGSARVWLASARPLTQRPLFLAISSSRLFSSKNNSELSPSTPDASSSLPPPPPQRWISDLRVRVGKCLMFGCNETQIARAALVMRALATEWRDLLAGSEGYLTGGRGGLDGREIAWGEQDTFGHVNNVNYFRYAESARVNWVTNFAVHDPENREQWLELMTPKSTGLIMRGIKADFKFPLVYPDKISVYHRLSSPPLPEVTNLNQGESQPPSFFTLTSLVLSHNHRRIACRLEEDIVIYDYIRGAKTAMPPFMSRVLEGVWREQERETRRARERVWELVAAVDGLERETWNREGAVEDLGTAKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2D3</accession>
    <name>A0ABR3V2D3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000514">
        <property type="protein sequence ID" value="KAL1835897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="306" mass="32458" checksum="FD91C6E331534913" modified="2025-10-08" version="1">MDRHSPPEFILEAFADPSSVRDIVRGILHTIFFLRYFPTILPQTRDVLGLELAYIPDAEIETLIDQRVAALARQLEAERHQPHSTGGGLGGYIRGGGGSPSTVGGGGRGQITIQFLEKRRRKTWYALRGDDEVPWESWTVKVTVADPRTEGGAFFFPIQFPSLLPPIQSPFVSIDSHLAHPGLLTLNKTERAKLRRASETTLHNTIMKAVTLANAHKDHIPPITTTESNPFPYQIHVGPPASGSSNTNSSSSAARPGSPLKEGPLSPSRSRATPTSGSGGGGGGGGGGAGGVAAAAAGWATRMGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2G8</accession>
    <name>A0ABR3V2G8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000510">
        <property type="protein sequence ID" value="KAL1835910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="161" mass="18047" checksum="57D3A3095AA63E9A" modified="2025-10-08" version="1">MASPTPKFNAKSPTIRRILREAHELTTAPSADYHAAPLETDLFEWHFTLRGPPNSPFERGIYHGRITLPPTYPLRPPSFRFLTPSGRFEPNREICLSISGHHEETWQPAWGVRTALVALRSFMETDPKGQLGGVDASEEVRRRLAGESRGWKCGVCDGPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2H0</accession>
    <name>A0ABR3V2H0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6041</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000533">
        <property type="protein sequence ID" value="KAL1835810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="11">
        <location>
            <begin position="441"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1835810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="518" mass="56893" checksum="BC6D6795B56CC9F6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2R8</accession>
    <name>A0ABR3V2R8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000599">
        <property type="protein sequence ID" value="KAL1835578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="49902" checksum="59DE083F5B063B1A" modified="2025-10-08" version="1">MTGQKRKSESASAVADTAPRRSERLKASTQQKQQQEEAKTTGQPTIQDGSVTQSSATSGAKDRPVKKAKLDRENPAPTAAGKEKKKGIKIRGSEQPQGGSGLGDPNISLPVTDHLHPGTLDFLRQLAIPANNISPWLKAANDATYRAARKNWECYVSDLARKIRTVADPTIPDHFPIKDIAWTIYRDPRFASDGCMYKTFFAATFSRSGRHGPHASYTLRLEPDGRSSISGGLTRLERDTIETLRESIDNHPRRWRRVLADRGLWESFLSKVDVPSSDHNNANSAAAAAAAAAGGCGGDGGAPPSTATRNSNAGSSSSGGGGGGGNQPEGQSYPTSNTTTASKDNDTSAATTTQGVAAATAAAAAAEAEVDPSKAIAAFVHLNRSTALVRRPPGCPPNHPDLPLLRLKDFVISAPLDDSVFLDPRGQDMLVGMVKDLVGFVHFLNRIVMPEKKQKDVGVKNKVEGKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2Y3</accession>
    <name>A0ABR3V2Y3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000495">
        <property type="protein sequence ID" value="KAL1835960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="539" mass="59149" checksum="B33967EBD835498E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V346</accession>
    <name>A0ABR3V346_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exosome complex component N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000448">
        <property type="protein sequence ID" value="KAL1836202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="5">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="6">
        <location>
            <begin position="121"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="38827" checksum="ACD2398F1AEF1C84" modified="2025-10-08" version="1">MPIKILAPKPPRPLHRPSHHDTSSSSSDSDSESDSGGAHLDADGDIPMTSHPSKRVHLDLPTTTSSDTSIVTPGELITSDPQWMRGHGTYIPPSTTSIISSVAGTVTRTNKLLSVRPLRARYTPEVGDLVVGRIVEVQAKRWRVDVGSTQLAALPLSAINLPGGILRKRTETDELQIRTFFAEGDLLVAEVQQLYGDGGAVLHTRSLKYGKLRNGVFVAVSGMGGGGGVVRSRRQVWTMEGANGAGLIDVILGVNGYVWISKHVEASEVDKAAGLNNMEESVSATVYSSQNDRIDVATMREIARLRGVVMALVENGLRVDEDMVVRGYQEAVEQAMLSDEGIEDVYLGGERGVRLAAALTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V348</accession>
    <name>A0ABR3V348_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000448">
        <property type="protein sequence ID" value="KAL1836198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="111"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="679"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1340" mass="150235" checksum="7C3D707990D6F4AE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4N3</accession>
    <name>A0ABR3V4N3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteinase inhibitor I78</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000395">
        <property type="protein sequence ID" value="KAL1836575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9047" checksum="5EEEBCC9FCEF8536" modified="2025-10-08" version="1">MPLVVPGVTADNLGDDQIQEWANKLVGKTISDGPSSETTFCKTELPQETRVIQPGSIVTKDFRENRLNVHVNEDGTVSHVTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V527</accession>
    <name>A0ABR3V527_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="JAZGSY010000357">
        <property type="protein sequence ID" value="KAL1836862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="244" mass="26671" checksum="60EC5DA4CD0B1F5B" modified="2025-10-08" version="1">MLSYNTSVQTVNGQRPPSPGRTTASRLPPSAFSNGVMTNGITSQAADASAPPQQPKVQHIWLVTGPAGCGKSTIAKHLADSLQFTFIEGDEYHPQSNIDKMSAGIPLTDADRWDWLTALREASISALASGSPGVVLTCSALKRKYRDVIRVAPYFTPNLDLHFIYLDAPEEVLVKRVGMRQNHYMGANMVHSQFEALERPRPEEVDVITIDVTRSVDEVKEDALAQVLRTIGADDEDSEDSPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5M9</accession>
    <name>A0ABR3V5M9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000338">
        <property type="protein sequence ID" value="KAL1837021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="135" mass="14601" checksum="AC13639D19CE120B" modified="2025-10-08" version="1">MPASLDSSRPIMAPSARTSVRFSTYSMNAPSITPTVVSTDSVNAEIRPIVDGLERLRNPRLADDQRVLLTETKSTELADLALKAKLERALDRRMTSQDAVMRPRRKSSVTLVAAVPPAPATAAGDVEVTDEKQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5X8</accession>
    <name>A0ABR3V5X8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="3 8">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4182</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="3 8"/>
    <dbReference type="EMBL" id="JAZGSY010000321">
        <property type="protein sequence ID" value="KAL1837172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="11">
        <location>
            <begin position="187"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="12">
        <location>
            <begin position="354"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1837172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="577" mass="64488" checksum="D1241BA972387D74" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Z0</accession>
    <name>A0ABR3V5Z0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000326">
        <property type="protein sequence ID" value="KAL1837126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109527" checksum="358C26234F60CB11" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V632</accession>
    <name>A0ABR3V632_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Suppressor of SUA7 protein 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4104</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000316">
        <property type="protein sequence ID" value="KAL1837222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1837222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="342" mass="37517" checksum="8ACFC5FA4788F29E" modified="2025-10-08" version="1">MPAPSLLESFHSTQQNFDTPFETSRLLQHSEQVNTAPAIAIHNEDIASWLSVSPSPGGPPPHSSIILNETAYSARDPSTFHSTMASTDGSAGSSAAAPQIEQNSASGFKLKFCTVCASNQNRSMEGHLRLAQANYPVISFGTGSLVRLPGPTQSQPNVYKFNQTSYDSIYRELEAKDPRLYQANGLLNMLGRNRAIKWGPERWQDWQIGAPRVKQLDQKDQGAAGMEAGVPDIVITCEERCWDAVVDDLMHRGAPLNRPVHVINIDIRDNHRDASIGGSAIVDLADSLNKVAVEERERVGPAVFDAGGAASRASFDERVPEVVSEWQERWPDLPATWTLAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6N1</accession>
    <name>A0ABR3V6N1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000332">
        <property type="protein sequence ID" value="KAL1837076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046893394" evidence="1">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="100" mass="10995" checksum="5C1DD101470D85F1" modified="2025-10-08" version="1">MRLPASFGLLTLLLALVAAQSESPDFPACTRELAETDECLAVINPNACYNQFRWSARTLSCIDAIDGTPVSEDVKKQWICKCCNCVGAVMCNWAARSRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V788</accession>
    <name>A0ABR3V788_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000306">
        <property type="protein sequence ID" value="KAL1837326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27977" checksum="A56182EC959AB7BD" modified="2025-10-08" version="1">MTSLPAIITPALLSSLRTHPNLPAHTWYFITAVTLSQLNRPDEIPKVYLHALQPSPGESPPSQDDKLRISRRMREALIKVAAVGGVPRTINALLELKKVTPEELLDTPEPSTETSSSLTGRRADVYDIPTSQVLQRGQTFFNDIYGKVARRVMSQMDNCGTEDLGLVARLMYGYVLSSTAVLGPAETSFVMIAGLVPQDVNPQLKGHLRGALNGGATLDQVRAVRRVVVDLCRAAGMRLLDPAEPGGFGWRSEPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7W8</accession>
    <name>A0ABR3V7W8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000274">
        <property type="protein sequence ID" value="KAL1837662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
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        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="138"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="592" mass="67109" checksum="B249C4A736986A12" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V822</accession>
    <name>A0ABR3V822_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000251">
        <property type="protein sequence ID" value="KAL1837928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="380" mass="42942" checksum="DECFDDF27402C0D5" modified="2025-10-08" version="1">MRWSKHKSVVGSLEGCDVVTVLVGEEEREFTIHRKILFDSCPFFRSYLDEIPNPSKPQDGSASSNSSSSDSDEEEDSALLLPSEAPDMFELFVLWLYQRRRFPFILDKAIQTMNPDKARTLRNDLVRLHLFAAMVDLPALQDAAMDALQDMYLRFDWDMSPRFLAFLYGDCDAQHAMRLRRWAVAMLAWTLHGPEKSVPTCTTPPGTGLTTTTTTSNSATTDFNKLFAAYPELQSDYHMHLHKMAMSRADVRVKNPQLRLPANKLQSGERYFGFRQCTFHSHRASVGEGMCPHALAAMVSTQHPLPAKLPELRGPPPGRKLPPPPPMTMAMAMARDVRDVRDVRGRDKEEVVSDKDEEEVEQLLISPVGDLNEISYLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V836</accession>
    <name>A0ABR3V836_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3238</name>
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    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000250">
        <property type="protein sequence ID" value="KAL1837943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="275"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="606" mass="67952" checksum="68CEFB729F74A1CE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8B3</accession>
    <name>A0ABR3V8B3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000244">
        <property type="protein sequence ID" value="KAL1838017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="eRF1" evidence="2">
        <location>
            <begin position="130"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31956" checksum="D7D3234977879613" modified="2025-10-08" version="1">MDGNGALFGTLSGNTREVVQKFTVDLPKKHGRGGQSALRFARLRDEKRHNYVRKVAELAVQNFITNDKVNVAGLVLAGSADFKNDLNASDMFDPRLQCKVIKVVDVSYGGENGFNQAIELSSETLGNVKFIQEKKLIGKYFEEISQDTGRVCYGIDDTLKALELGAVETLIVFENLEVTRWVLRDSNGSETILHTTKQQEQGNRDKFMDKETGQEMEVVSQDSFLEWIAEHYKDFGTTLEFVSDRSTEGNQFVKGFGGIGGILRYKVNFEQLAEVDDDDEYYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8L4</accession>
    <name>A0ABR3V8L4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000297">
        <property type="protein sequence ID" value="KAL1837408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="154" mass="17256" checksum="08FCE0FF941CEFB9" modified="2025-10-08" version="1">MAPQKQPQPPFHVNERVLCFHMEMLYEAKILDIQPAEKGEGWQYKIHYKGWKSSWDDWVPQDRVRKFTDENKELAAQLLAQFKSLQASKSNKQSAKKGAASSSSAARAVVNGSELGSARGSEERTAGAAATSSRGPRRTRDYDLEQVSTFSIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9B3</accession>
    <name>A0ABR3V9B3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000215">
        <property type="protein sequence ID" value="KAL1838424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="279" mass="29918" checksum="1830832167A6DF45" modified="2025-10-08" version="1">MKPGHTPTASLDASGSAEPVHVSITLCGDGGCGKSSITMRLVANRFLDSYDPTIEDNFRISRRVDGVPHLLTLTDTAGQEEYRGMWASSNLAADAFLLVYDITNRDSLDALDYFNELIDMEAEAREENLARARRAGLPLAMTSYSSSTTSGSGANRVVPPIKVVAGNKVDLQESRRVPATVGLDWARRRGCGFMETSARMEVNIEETFALIVRRVMEARRAVEMGVAPGEQPGLGGDEKGKTQPAGALPHSDGGGGGSGGDEKKGLKGAGGFWRRLRCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9C0</accession>
    <name>A0ABR3V9C0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000224">
        <property type="protein sequence ID" value="KAL1838297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="864" mass="96631" checksum="ADC186B219CDC1F1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9U6</accession>
    <name>A0ABR3V9U6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000222">
        <property type="protein sequence ID" value="KAL1838322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="217" mass="24046" checksum="3103D51A8336EE11" modified="2025-10-08" version="1">MPSLRTTGASAARLMRTAAQARHAAAVVPATRRYESTAKAPATSTYIAKGEEAKKELSPMATLPRNAPDYNVPIDMATSTFTPVPKHVQDGSEENLVPAGLISGAPIELQARTVRIYKPSKPATQSGEHKSGRWRMDWDVLGKGHRWENPLMGWQSSADSMQGTHLSFKTKEDAIAFAEKQGYEYYVQEPNERKFVPKAYANNFLYSPGKLKHIRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAK3</accession>
    <name>A0ABR3VAK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="287"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="382"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="486"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="524"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="645" mass="69884" checksum="910095C6E04B727F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAN1</accession>
    <name>A0ABR3VAN1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000193">
        <property type="protein sequence ID" value="KAL1838789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="68420" checksum="BA1FF33E4278C83A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAN9</accession>
    <name>A0ABR3VAN9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RuvB-like helicase</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_2080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="JAZGSY010000187">
        <property type="protein sequence ID" value="KAL1838889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="68"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1838889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="478" mass="52004" checksum="FCBB3357D415D708" modified="2025-10-08" version="1">MAAPVVTVSETKDLRGLNLIAAHSHIRGLGVDADSLEPRVASQGLVGQEKARKAAAVVLEMIKQGKIAGRAVLIAGPPSTGKTAIAMGMAQSLGFDVPFTTLAASEIFSLEMSKTEALTQAFRKSIGVRIKEESEIIEGEVVEIQIDRSVTGGAKQGKLTIKTTDMETVYDMGSKMIDAMTKERVMAGDIISIDKSSGKITKLGRSYARSRDYDAMGVDTKFLQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIRSEIRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSYINRALESDLSPIVIMASNRGHARIRGTDYKSPHGLPLDFLDRTVIINTHAYGPEELRQILSLRAAEEEVDLNADALALLTKIAQEAGLRYASNLITTSQLICAKRRAKQVTVEDVQRSFKLFYDPARSVRFVAESEKRLIGNDGAVDFSVKENGTVVGTAAGGDTMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB39</accession>
    <name>A0ABR3VB39_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000190">
        <property type="protein sequence ID" value="KAL1838840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028115">
        <property type="entry name" value="DUF4484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14831">
        <property type="entry name" value="DUF4484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4484" evidence="2">
        <location>
            <begin position="458"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="723" mass="77552" checksum="60BA55C68F277C4B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB59</accession>
    <name>A0ABR3VB59_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Modin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000184">
        <property type="protein sequence ID" value="KAL1838948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56918" checksum="B5F829351E79730F" modified="2025-10-08" version="1">MGKGESDEAELNVSIVALLVAGAALFLGLAQVFQSYLATAVGYANCGKRVLGSWAAYSKLKFHWRPLRFEVLFTSPHISVCMCGSPSSHDEEKEYSIWPGLKNGGLHCESPTTDDRDCLASWLSLLSTLRDMEWSREIPGGAAQFMSGDVHIVLRHKDQTLDLMPDWVKKPYATTTLSSIVSIAAMLGMRWKQFNRTHDRYVAEGNGFLMTGRLVPSLGIMFSFTRHGDPDFVRRRAIPATDTIEYCFGLVPTIFRPLNVGMPQNLAETPCDLGTLRLGNRADITRTIKLLLFEQSQIEKLDFNQEFPVLFELIGMLGRVVQIPNTPWRMLPNPLPFRWDMGSIHGPNLLFNELLPDLILRARGLAEQFSTPSCQITPLQANLELMTKLREAIGWCDEWLNPHSPTSWLEILLVIREHILADRGRLPEYSEDQAGVRIRHYLNRVHPKVEQNLRTVWAVEQAVGNVSENRTARAIWLVLVFRMTDSKDLRMADLMGTSLPVYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB72</accession>
    <name>A0ABR3VB72_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000179">
        <property type="protein sequence ID" value="KAL1839022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="8"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="350" mass="38047" checksum="3C271693AB2D102A" modified="2025-10-08" version="1">MKAVVFHGPKKVAVEDRPVPKLQDPTDIIVKVQSTALCGSELHVYRGHQPSPTGFIMGHEFVGTVVQAGSEVKSVALGDKVVAPFTISCMTCFYCTHGFSSRCAHVRLFGSAPLDGGQAEYVRVPFADGTVMKVDPSTISDRALVLMADIFPTGFFGAKNAFALLQPHQQPDEAVVVVVGCGPVGLCAIVAALEYKPRKVFAVDNVKSRLELARELGAEPLDFSEGTEAMLKRVKEVTEGRGADAVIEVVGLSPALRTAFDLIRPFGVISSIGVHNAEIPWDGNEAYGKNLRVQMGRCPVRSVFHEALPVLAKNQDKFNFMFDKIMPLSEAVEGYELFDKRKVQKVIFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBE3</accession>
    <name>A0ABR3VBE3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000189">
        <property type="protein sequence ID" value="KAL1838862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025774">
        <property type="entry name" value="PiNMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51581">
        <property type="entry name" value="SAM_GTMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif I" evidence="4">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif III" evidence="4">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="387" mass="42143" checksum="AA14C04E6FBFDABE" modified="2025-10-08" version="1">MATISETTDLSKQYDTPLGLAHTTMQALKDRIKQHYDLASDYYLNLWGEHIHHGYWPTDESKANDSKETAQLNLIRLLLSIADLPVPLTDGKGQEGSHEPSGDKSHHDQHPLRILDVGCGLGGTTRFLASSLGAAVTGITISDTQVRIASRLTENAAAAAAAASAVTGSADEGTGRSTPPNDARPGNNQEADGEGEGKKINTFIPLGPLGGKVRFLELDAEKMAEFFTSPSSTDRGGEFDIIWISEALSHLPDKPRFFRSAHRLLVPGGKLVVADWFKAERLSEAEVETDIKPIEDGMLLPALHTQADYIRLAEEAGLRLLNGPLDISKDVSKTWDISWSLVQNPSLWAFAFSQGRDGIAFLQAFRAMRRGYANGSFRYGVMAFVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBJ8</accession>
    <name>A0ABR3VBJ8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000175">
        <property type="protein sequence ID" value="KAL1839091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="144" mass="16011" checksum="564041AB6C251D46" modified="2025-10-08" version="1">MKSLRAEMRVQAAIHVAIESLEFAEGQLNVMRMGGDINLLQKHFYEGYNRLLHRALDLQRQELGSLPGGSGPPQVTIPEVQINGFQPGYNTLQPPSSILLSNTTIRPKSASNATRSNGIIFADQLAQRPFPRRNTIQGTREECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBK9</accession>
    <name>A0ABR3VBK9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">High-affinity methionine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000194">
        <property type="protein sequence ID" value="KAL1838771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="84901" checksum="A845C1B1D53DA01A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBV4</accession>
    <name>A0ABR3VBV4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000167">
        <property type="protein sequence ID" value="KAL1839262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03477">
        <property type="entry name" value="Rieske_YhfW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038010">
        <property type="entry name" value="YhfW_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF281">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="459"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="559" mass="61698" checksum="51449DB618A10D7A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBZ7</accession>
    <name>A0ABR3VBZ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF747-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000161">
        <property type="protein sequence ID" value="KAL1839363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75640" checksum="33DC2DBF6B2FD436" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCC7</accession>
    <name>A0ABR3VCC7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000153">
        <property type="protein sequence ID" value="KAL1839514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF95">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="200"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="655" mass="73476" checksum="4F765104EBE4E1DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCD3</accession>
    <name>A0ABR3VCD3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000152">
        <property type="protein sequence ID" value="KAL1839520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="420" mass="44426" checksum="0D5A68AEC48C0428" modified="2025-10-08" version="1">MNRHALRCALGRSAPSLTRRAALCTPLSTATPTTFFSTTTPALADTDSPSSSSTPNPARSRSRSAVEKITQLNNKRNNALPAGPFKSSNQGPAPRIIDARVLKVSPNGPSPSSGPKVLNLRSLRGRGGSIGARRRAPFPADGGQIISRAPERFGARAGARTGGRLGAAASKGRGGGRLGARGVLAAAGGGGRRARGGARRSGGIRRGKSDKDDGNKAQQQGSKLTWTPEEQAVIDRIEKGEVVRFDPKLPTADKLAGYGSPLATDAPQGRVETVLRAMRVMTGGMAFNPESGVTADVREVIKRYRAKKPVFVHSQAEKEWIEWAKPKYRLVGPNEAVKKAILNTVISGKYEESPDFADLSDAKGMTAAELSPTVKRIMAAQLSRTGTYTSNESKRLMDKVLSLLPQQAEGTAAPRAPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCG4</accession>
    <name>A0ABR3VCG4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_1470</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="14">
        <location>
            <begin position="57"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1839495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="459" mass="48222" checksum="0E01BF6EDD65DE05" modified="2025-10-08" version="1">MKTRILKVPLAGRDESALGSWATGPNGKPDLNHWIVPASSSPSSPVENGKQDNDGVLAPLREAAHILRTTSSPVAFPTETVYGLGADATRSDAVRGIYAAKGRPSDNPLIVHISDLTMLRRLLMPGRRQPDLDQPPHLDRDGDDNDSLFHQDDPIPSIYHPLISRFWPGPLTILLPLPSPSPLAPEVTATQPTFGARLPASALARTLISLTGSPLAAPSANASTRPSPTAARHVRDDLDGRGVALVLDGGVCSVGVESTVVDGLCSPPAVLRPGGVGIDQLRECKGWEKVVKAYKDKGEESKPRAPGMKYKHYSPRARVVLLEKAVADKTKGVVEEDLRGVGGEQGLTVGVVRTGGWGVAGGLRCAGMKEVAGGGGEGEEMGFVVMEGVLVRGDEEIGRVLDVDLGGDVGGVAHGLFAVLRELDRLGTDVIFVEGVGDGDDIGAAVMNRLRKAASEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCI9</accession>
    <name>A0ABR3VCI9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000186">
        <property type="protein sequence ID" value="KAL1838908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="6">
        <location>
            <begin position="131"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="449" mass="48861" checksum="928DEBAFEDEAA4E6" modified="2025-10-08" version="1">MASRTRLPPPTTLSTLTTLTTRRLPSSSYLPLQTANQFFSEHHHRPFSSTSTTSSPSKYYPPRVPPKPLYSTTPPAISYLPPPSNDPTQHAVPSPPPHEASLRDASSIFTQQPPHFLYSASKFLQVPPNSHTPEICLLGRSNVGKSTLINALAGVGGQAAARAHGLKARSSGLAITSKISGSTKSMNAYGFGVPTKAQRQMALERAAELKRERELAQKLTAGRRGSRAERRGVVHEPPPQFRLIVVDMPGYGLGSQKWWGLEIEKYLRRRVMLKGAVLLIDAVAGVKDADRQVMELLRDCGVRTAVVLTKADKLRKKEEGLEAEEVEMHAEARVEGVCLDVWDELRAVERVSLTWLEGAEKGWEKEIWVTSAGDVDVRGDGAGVVGARWAVCRMAGLVEDNRVLKPVVTPLTAPSKIVRFEDLQFGTAPATPKEEPSDSGTASDAEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCP0</accession>
    <name>A0ABR3VCP0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="107" mass="11753" checksum="8980293B11CD3ABB" modified="2025-10-08" version="1">MISDTELYRLAIVLGSAAAMLIILYHFLEVNSDKKESDANAFSAITDHNIKKPTILSCCLTASIAARRVSSNHRDTKPQVTLDHLLESATLPTTAKADKKLLHRVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD77</accession>
    <name>A0ABR3VD77_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="209"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="581" mass="64262" checksum="E9122C5FFF375BCF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDX1</accession>
    <name>A0ABR3VDX1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000129">
        <property type="protein sequence ID" value="KAL1840068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF8">
        <property type="entry name" value="STRESS RESPONSE PROTEIN RDS1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046854016" evidence="1">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="320" mass="32776" checksum="132B52AF027D1D99" modified="2025-10-08" version="1">MPSIRSTLGAIVAGLAAVTSALPAVPKLTSSQMKMYELAKRQNAAAQALGLTDIDILQFALTLEWLEATFYQQGFAQFPASDFQALGLDQRQIDDLLKIGKTEEEHVVLLQSAIAQAGVQPVQQCQYNFGFTDAAGMVATAAVLENVGVSAYLAAAALISDGSILTTAGSIMTVEARHQTFVRTASKAVAIPSAFDAPLSPKQIFSLAAPFIASCPEGSNLILTAFPTLSMAPGAQATAVAGASIQLQSDAAAGATHCAFTAGGLVPGGTAFTPFDPATGCVIPQGLSGLVYVNLASAGPLDGKLTDEIIVAGPMVMQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE98</accession>
    <name>A0ABR3VE98_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000123">
        <property type="protein sequence ID" value="KAL1840189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="670" mass="74994" checksum="8B5B0979E81E845D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEC9</accession>
    <name>A0ABR3VEC9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF0">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="343" mass="36681" checksum="22D815F0781B9617" modified="2025-10-08" version="1">MSLELDTLPPPPTVSMQTINMAGLPVDVYGLADLAASVTRVSCLWLHHPRTRDRAHLADTAARCVGAWNARREGAQTRGLVALAYDQRNHGSRLVDEKANGSWRDGNPRHAIDMFGGIMGMVGDQRGLLDLVEGYLFPDSNIKIDQHLALGVSLGGHSVWQLMMADPRVTVGVAVIGCPDYMTLLTDRARLSKLSTFSVSDAGASFLGSKDFPPSLVESCKKYDPRGIFFGTSPIPDPDHGPGGPAAAQVAAAQQILRERLAGKKLLVCNGGADKLVPYRCSEPFMKWFKRAVASEGVVVDDRVYPGVGHVFGADMITDAVEFVVDAVASAGGSGEEVRASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEJ4</accession>
    <name>A0ABR3VEJ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="869" mass="96264" checksum="09EE9A756BEE7A3D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEL1</accession>
    <name>A0ABR3VEL1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000123">
        <property type="protein sequence ID" value="KAL1840184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="2">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="317" mass="34886" checksum="0061C6D7BC7FD068" modified="2025-10-08" version="1">MQVKNACARRASLQPRTPRIVGNNNSTTTSLDEQHAITTQILGFLLHPFIPPPSPTAKIADVGTGTAAWLLDLARSLPPTCQFTGFDVTPSGFPHESARPKNVTFKLHDMFVPFPEEEHGNYDVVAVRFVSSATRRGDFARAVGNLVKLLKPGGWLQWIDSVNFGLYCGVAGLSREACQEVYEGLEPFRSQAAGGENGKGEDDGGPVIGLFVRDAWPSKARAVRERVFQEQGLVDVHEDVFSTDRLQKPELRLREKGTRNIMDCFLGCLGELVGVEGSGWTKERLDALRVKVMREIDGGVYHTLDQVCLVGRRPEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF19</accession>
    <name>A0ABR3VF19_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="218" mass="24283" checksum="722C63553220C097" modified="2025-10-08" version="1">MSHVGSGKAASSKEQTGLRYPSNGKTIYHRPLNRTKTAELSQAAFAYLFSEMVIYAQRRVAGIQELEKRLNLQGHPIGLKLLDLLLLREPPRSQTRPLTIIALLHFIKINVWTHLFGRQADRLEKSSNPDTPDEYMIVDNEPLVNAYISVPREMSQLNCAAFVAGIIEGVCDGAMFPARVTAHTVGGKEEGEMWPGKTVFLVKFQPEVLEREALLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFJ3</accession>
    <name>A0ABR3VFJ3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="109"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="246"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="336" mass="35808" checksum="424D338EFB290D25" modified="2025-10-08" version="1">MSQPPPPPFQTALLAGALAGTTVDLSLFPLDTLKTRLQSAEGFFASGGFRGIYRGVGSALVGSAPGAAFFFCTYEATKSALARPRLIRGSEHSTPSPHNKALESGELALEHMLAASAGEIAACAVRVPTEVVKQRAQAGLHGGSSLSALKHILSHHNPSHHGGGLHSSIKGLTAVWRELYRGWGITVLREVPFTILQFPLWEALKAWGRERKARTGRGLFGDANIPPPSSHHSHRHQPLTEVSAPESALYGSLAGAVAAGVTTPLDVLKTRVMLSTQRESAWSVVKSILRENGVRPFFAGIGPRVAWISVGGAIFLGSYQWAVNALTRIEGRRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG12</accession>
    <name>A0ABR3VG12_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19473">
        <property type="entry name" value="SET_SUV39H_DIM5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="11">
        <location>
            <begin position="77"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="159"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="547"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1840681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="622" mass="70199" checksum="991C87DB4A3F30B7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGA6</accession>
    <name>A0ABR3VGA6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="640"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="769" mass="82981" checksum="722EA93DD08370A6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGC5</accession>
    <name>A0ABR3VGC5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="56222" checksum="F5E0FF6C201CC109" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGH1</accession>
    <name>A0ABR3VGH1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000100">
        <property type="protein sequence ID" value="KAL1840763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="112431" checksum="817EB8D289AE3038" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGN2</accession>
    <name>A0ABR3VGN2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="411" mass="45825" checksum="F539BCADCA900FCF" modified="2025-10-08" version="1">MDYLIRFSQSHETFRLPEIEALALLEGVDLKVISYSLDSPFCIVRLPSEDAARRLIRRSILTMSIHELWAHGPDLTAVHSAVKRDTGHLWPRYRTCSFKFSIDSYQGSRGSDAKVRIIESFSYLGFEGPIVMRGADEEFVLFEDWPFNASRLGIPEPNYFYFGRFLGGGARDLPKKLDLKKRRYISTTSMDAELALVTANLALAGPGKLVYDPFVGTGSFPIACAQFGALTFGSDIDGRSIRGDSKKRTLRANFEQYGLLAGLGGMFTADLTNSPVRRTALRYDGDGVTGRIFDAVVCDPPYGVREGLKVLGVRDPEKSLGVELRGKEMYKNPDFIPPKKPFSFLAMLDTILQFSAQTLVDNGRLSFWMPTANDEDQEIPVPTHPYLEIVSGLDDSSHTAASPTPKWTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGU4</accession>
    <name>A0ABR3VGU4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA primase large subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000090">
        <property type="protein sequence ID" value="KAL1841009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="663"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="870" mass="98647" checksum="FB81CB7DA0FC205B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGX0</accession>
    <name>A0ABR3VGX0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000100">
        <property type="protein sequence ID" value="KAL1840767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="270"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="689" mass="77294" checksum="C723E685A3EB65B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIN6</accession>
    <name>A0ABR3VIN6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="271" mass="29021" checksum="672FF94BD908489E" modified="2025-10-08" version="1">MLGGWFVDIQHPARLRGPLWGDLKASRPVSSLSLNSYHDFDDFLIDNLSWDPAINALDFTDPTPSSLPDGHDLSSLATPTLAGLDFASTNLDPLTVPLLNGFASLAVPPPSSSPPAPSLTNTPTTAPLQSPSPDPPSSIDESPLYPGLKLPPAKPASSSRPGRRPAGASLSRTVDGRVTKPSSGTTPTANHTATAAAEDVGPEVLDRRYRNNLAAKRYRQKKIDRIQELEAEVRKVTEERDDLRIRLARQEAEVAALREMLKLKIGGGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ55</accession>
    <name>A0ABR3VJ55_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046027873" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="72"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="653" mass="68092" checksum="530095AE3AC13F59" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJN1</accession>
    <name>A0ABR3VJN1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="5">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35795" checksum="684416A321114647" modified="2025-10-08" version="1">MSKTIHITSPSQFNNLLSSSKFVVADFYADWCGPCKQVAPIFEQLSTALSRPGVLTFAKVDTEAQKDIATAYRVTALPTFVIFRNGKVTDRVQGADPVKLQSIISKLTDAASGDSGAEASGSGNGSNNGENWRGAALPRGYGDITKEIELRHCELLNVDPDVGSVRVLFDPSKPSALSGSKGAKDWVESDTDEQLLLFMPFQSMLKLHTLQLTSLPPSGDDDDDEDAPMRPRTIKLFTNKPHNLGFDEAEDLSATQEIEISSDDWNAEGTANIPLRFVKFQNITSLVLFVVNGDGDGEKTRLDRVRLIGEAGEKREMGKLEKIGDEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJP1</accession>
    <name>A0ABR3VJP1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="45"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="361" mass="38869" checksum="51DED229A4F3F88E" modified="2025-10-08" version="1">MDITKKRRRIALGCEGSANKLGVGVILHEGDLSDPSSCTSTVLSNVRHTFVSPPGTGFLPKDTAHHHRSWFVRVAQQALTDAGLSPHEIDCICYTRGPGMGAPLTSVAIAARTLALLWNKPLVGVNHCVGHIEMGRAITGASHPVVLYVSGGNTQVIAYAEQRYRIFGETLDIAVGNCLDRFARALEISNDPAPGYNIEQLAKKGGRVLLDLPYAVKGMDCSFSGILTRVEELAAQMKAGQGKGPDGEPYTAADLCFSLQETVFAMLVEITERAMAHVGSSQVLIVGGVGCNERLQEMMGAMAADRGGSVYATDERFCIDNGIMIAHAGLLAYETGFETPIEESTCTQRFRTDEVLVKWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJT2</accession>
    <name>A0ABR3VJT2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="223"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="484"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="532"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="604" mass="65703" checksum="9581FC94241135E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJU9</accession>
    <name>A0ABR3VJU9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="471"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="634" mass="70751" checksum="446589B026AF46A0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJV1</accession>
    <name>A0ABR3VJV1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000064">
        <property type="protein sequence ID" value="KAL1841766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="474" mass="57081" checksum="F0DE462F0F6F592F" modified="2025-10-08" version="1">MAQFLAAVPLPTEVLQLIVRELDPIALIALSQTSKAWRAFIRPIRHDFEQRLLALELHPDYGGLVPNWDEYYQKLTPPWDSPEWKTTKYACCGCMKLLTHMMFDNHAILRRHWRKPSVGSVEANKALRTDWEPFEPALRWQRIQDRARQAREAQRRWRRILDWRRDYLLTNPPTNRFEHRALSPTAEEGDAFRRLIGTDRRRRRCVECQRLSGRWGYPRRSRPAVANSRQLKFQSVWERFVPGLLEQLTPDRFPDYWRCIRESSDGVYLTLRVAWCDECCTWQEWAAFRDWRLYGPDYRAEDSFPPLEHVCVKCAVRPPRDQEAEARRVQNRILTFLRDSDTAWRLGFGWRWVREDLNNQPDGDKIRTEVLDGLTLEKGRPGYLDQVVVEESNIPDLRRRLLRYRDFVYNEVDEETRNELVSSWFKLWLDQYERLEEVYFLQKRLIQKLEKEPKLILNYMLERDPYYVGRASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK15</accession>
    <name>A0ABR3VK15_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="650" mass="67584" checksum="3EE0AE6FDD9731F4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKA0</accession>
    <name>A0ABR3VKA0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5868</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000051">
        <property type="protein sequence ID" value="KAL1842181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="372"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="724"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="833" mass="90237" checksum="0B9CD98D06F1D409" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKF2</accession>
    <name>A0ABR3VKF2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="239" mass="27042" checksum="C0E86A9CBA6BB6FE" modified="2025-10-08" version="1">MYTKPESATDMAVPGSNCRPPANLRVDSREQHRDVAARPDTVSESHAMPCRSMPSMSTRQAKSPETPYPTMPVLKTQSYNAMAPLRFSRRCNRPWMPQKTRKPWEDATVSCCPMLRQHIRSRAGEFPMTYSIDDDSGEHGGRHGRPVFGIVLAADELRMIVLEQETEGTQDDDRKGRDDEAIRACVSVKGAVDSRECIRFQRSDAGEAALLTKTMLAPRSRWVSSCNLQRERRSRLWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKI2</accession>
    <name>A0ABR3VKI2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24454" checksum="FD8B587B0AA71E97" modified="2025-10-08" version="1">MGDKVTEEETPFPLTDVDRWVLSQTDEEFQCHTWEELRELIEANNLSALKRKPSDLRRYIKWTAETKAKYGSTTNYLLAHRLPKAWGSPPFTPASNTPFADPSDYRVLINDWPYGFVPGITHIVVWSRTPIPTDDTVGDMTPESRKLVNDFVRRYFVDRLGPGGEEKVMWFKNWVALQSVRTVDHVHVLVRDVEPEVLQDWVRELECHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKQ4</accession>
    <name>A0ABR3VKQ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="163"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="615" mass="69252" checksum="92411F9A580D54B2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKU7</accession>
    <name>A0ABR3VKU7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="348" mass="37482" checksum="8DF700794D5EB10A" modified="2025-10-08" version="1">MDNFGVIEIASTTTKTTPGWAYVPDTGPAVPAALQPTNRKRAARNQPALSLSDLSAREETRLRKELEALDRESHRDVSIPIPPRPGRAQTKHTPNVRKILQSQKTFANHLDDFQAMLALAESNPAAAAAMAATQAKASTPSAAASKSASPAPTAASTTGANSGTTASKRAVAAAKRAAAKEKQEQERKKARQTPKKSEPPEESQPPPPADVEMTDAAPPQQPPEDEGNPQTYPRESQILPPYARPPPRPHPGDNDPLLISRVPPFPSDDELRALMTAPPLNYLEARATWDGSGDGTDVGDQGSRYPVRVFCAVCGYWGRVKCMKCGTRVCALECLETHREECITRYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKW9</accession>
    <name>A0ABR3VKW9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05359">
        <property type="entry name" value="ChcA_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19531">
        <property type="entry name" value="LCL_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1445" mass="158625" checksum="0A02AAA370D915D0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL55</accession>
    <name>A0ABR3VL55_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="168" mass="18172" checksum="3B3604B79FE17EB0" modified="2025-10-08" version="1">MKAILQRVLSASVTVDQQVVSKIGKGVLVFAAMAPGDTEKEAESLAAKVLKLKLWDDESGGRWKKNVQDIDGEVLCVPQFTLLASTKKGSKPDFHGAMGGDEARRLYEYFFSRVQAGYSPDKVKNGVFQAMMEVALVNDGPVTLELVAQPPKANNSSQDRPQAKASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL98</accession>
    <name>A0ABR3VL98_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="112"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="427" mass="46015" checksum="88423C66E4C0F7F9" modified="2025-10-08" version="1">MPTRADITYFGAGPAALPTDVLEIAAQALLDFNGTGLGIAEHSHRSELATNIINEAKADLANFLDIPTNDYEVVFMQAGGTGEFAASVYNLVGAWVARQHAAVVAELGSGADEAAVVAALRDRVEKKLKVDYIVTGGWSLKAYQEAIRLLGPEYVNLAADARTINDGKFGKIPDPSTWKLSEDAALVYYCDNETVDGVEFPQFPAVLAPRPDGSGPVVVADMSSNILSRRVPVSNYSLLFFGAQKNLGCTGVTVAVVKKSLLPPTTSQPSPALLRKLGLPVPPIMLVYETIAKNNSLYNTLSIFDVFVAGQVLKKLLRTFPDKVDGQQAVAEKKASLLYSALEKYPDVYRIVPDKSVRSRMNICFRVTKNGNIDESEKTFLKEATAQGLTGLKGHRSVGGIRASNYNSIPLEGAEKLARFIEKFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLD9</accession>
    <name>A0ABR3VLD9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4563</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="315"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="570"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="661" mass="72177" checksum="7A558F806F4209C8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLH7</accession>
    <name>A0ABR3VLH7_HUMIN</name>
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        <recommendedName>
            <fullName evidence="11">Exocyst complex component Sec10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3349</name>
        <name evidence="8" type="ORF">VTJ49DRAFT_4840</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
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        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <begin position="58"/>
            <end position="184"/>
        </location>
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            <end position="862"/>
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    <feature type="coiled-coil region" evidence="5">
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            <begin position="65"/>
            <end position="96"/>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20667"/>
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    </evidence>
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            <dbReference type="EMBL" id="KAL1842557.1"/>
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        <source>
            <dbReference type="EMBL" id="KAL1843035.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLJ3</accession>
    <name>A0ABR3VLJ3_HUMIN</name>
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        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_4556</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="838"/>
        </location>
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        <location>
            <begin position="839"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="920"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1000" mass="106431" checksum="90E0B85AED594A3B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLS5</accession>
    <name>A0ABR3VLS5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="386"/>
        </location>
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        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49358" checksum="B0F7958A2C6C32BB" modified="2025-10-08" version="1">MATNRTLYTAADSIAQSRGLPGPMASLSSTSGRNPASSHISKTYRQASTLFLTRRLPEALSTVLPLVTPTPPAEGTSESTEPAPVVRASRSSRIKVWSLYLTVLNAIVELGSDEGKDAFGAQEWKAICHKVREGEVWEEVVRNGYHGVEGDVDAEVVINLATLLLAHAKTQTLNQKRLENYLAASRTPNLDSIPSDRFSESPRRYRSPRRGAPSGADTPRDLNARVKLLELYTLHVLPRNGEWEYAREFISVSPVLDDERRDAFLQALDTLREETEAAERREEEERRKREEAIRRDIEEARRLRAENEARERKRIEEERARREAAEAQAKASASVADFGVDGSTTPPRRRGTPAAAGSRSPASSRGLARSKGPVARRAGSGNTVATPTLMSRATTVLRNLRVLVDEVASAFRTNPRKKIRERMARAIGVAWAKVKATAGMGTKVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLS6</accession>
    <name>A0ABR3VLS6_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_4131</name>
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    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
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            <begin position="368"/>
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        </location>
    </feature>
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    </feature>
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        </location>
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        <location>
            <begin position="644"/>
            <end position="660"/>
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        <location>
            <begin position="675"/>
            <end position="686"/>
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        <location>
            <begin position="698"/>
            <end position="711"/>
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        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="805"/>
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    </feature>
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            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
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        <location>
            <begin position="898"/>
            <end position="910"/>
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    </feature>
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        <location>
            <begin position="929"/>
            <end position="954"/>
        </location>
    </feature>
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        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1197" mass="124421" checksum="641D0F8242A60AE1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLT8</accession>
    <name>A0ABR3VLT8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="618"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="646"/>
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        </location>
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        <location>
            <begin position="301"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="827" mass="90947" checksum="3D2140F633C345DB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM40</accession>
    <name>A0ABR3VM40_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1423"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1519"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="542"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1548" mass="173860" checksum="8202009C5D1452C2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMV7</accession>
    <name>A0ABR3VMV7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="11">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3202</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="11">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1843067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="235" mass="25203" checksum="7C988BFD767509BF" modified="2025-10-08" version="1">MAPLQTLPRALARAASSRLPTQAVRAVSSTPAVCAAGSSSTFESPFVKGQPKTTKVPDFSKYMAKGAAGKNALYSYFMVGTMGAITAAGAKSTIQEFLVNMSASADVLAMAKVEVDLNAIPEGKNVIIKWRGKPVFIRHRTQAEIDEANSVNVSSLRHPETDEQRVKQPEWLVMLGVCTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPEYEITDDNKLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN08</accession>
    <name>A0ABR3VN08_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="460" mass="49574" checksum="D23C07DDD5F1D1AC" modified="2025-10-08" version="1">MTGPIERQDYGGTGPLGSLTLVFTPPCPTSWLLTTTRLFSQYPPFPTTGPTSCDPPAWRANIAEAGFRYYSPAVCPHDFEVGPSCRITKTRTSEGFPAVQPGETAVYCVPKGLTCTTDITDWRGGVWGFATRDVFVTVGPAIQIRWAEADLTALETHPLTPGLKLAETIAGAVSETNMAMPTTEGPIPTHTTPEPTTLIVASTTVRVTDETFSLIHETARPTTELAPASTAGTNGNSGIGSLSRTTGIIVIVLVTFAAGVIIWTAAFLVARRYKKRLENQKKPGDLLIEPNKPWLGQNSWLRSPSLQPPWYSPRSVLSSNSRMIRESFGEKINDPAAALSRLKIPKPLSLSSPRSASPSARSFRWRLPRSPRKCESDTCASATGISGASTPSPAARAAMDHTGAWQPRLDRRQSWDRQEYKHAMLAQQQLFAAVSPAGRKEGEANGEVKGDIGIAGFSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN41</accession>
    <name>A0ABR3VN41_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1843004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="750" mass="81032" checksum="9989BEDDF3D2CF55" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNF2</accession>
    <name>A0ABR3VNF2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="430" mass="48578" checksum="84B2BEFA0A31E88A" modified="2025-10-08" version="1">MAVGRENGVHANGGQNGVGEDHIRYIPLSYDSTNSDASALRLVFSIRPDWQDADSKVEFVRFTDGITNTLLKAVNKRPGLSKDEVDREAILLRAYGHGTDLIIDRHRETQNHELLMKHGLAPELLARFENGMMYRFIQGTVTQPEDLRKPDIYKAVARRLAQWHAIVPCISGRTGHSRKTSRADGTPVTDDEFQRALDQVAPGKPPPNLWTVMQKWIFALPTDTEAQRARQAELQQELKRLIAELSQRPGLGVNGLVFAHCDLLSGNVIVLPQSTEKAADPTVAFIDYEYATPSPAAFDIANHFAEWGGFDCDFSVLPTRAQRREFIAEYIDAYFQYLEEKTPGATSQLDKQAEVERMLGEVDLYRGVPGFYWGIWALIQATISEINFDYASYAEARLGEYYAWRAEVSGEREKAGREMPLRERRWAQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNR6</accession>
    <name>A0ABR3VNR6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="482"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1144" mass="123907" checksum="1036964912A247E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP07</accession>
    <name>A0ABR3VP07_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="8">
        <location>
            <begin position="79"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="8">
        <location>
            <begin position="689"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="893"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="944" mass="103518" checksum="EFF5A126EF9FEF97" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP36</accession>
    <name>A0ABR3VP36_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="664" mass="71757" checksum="9097151C17AEBA22" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPX6</accession>
    <name>A0ABR3VPX6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_99</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="241"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="443" mass="50481" checksum="31DC964A209DAFC0" modified="2025-10-08" version="1">MAFDSVFFNEFSDAWSRRDGYRLARTLSPEVSAEELKTIYNSTNAHDIKSSVRRGLQGNAALVVGIARDEINAARESDGGNDSESPQLVWTKVFEAWTDVLNQLLRGYQNHGFEAWTIPCLYIVCKNLRAFAIKADDERNSSSVEDTTANNLQDDFDPDTNKNQKLEECARTLSRVFMICQTDRAPIEESRKWGSYYIANLLLKTYFKLNSASLSKNILNSLRASGRDMPDFSAFPKSQRVTFKYHEGVLAFLEENYVQAETCLTEAWDLCHKDAVRNKERILTYLIPCHLINNHTLPTKKLLEPYPRLQKLFLPLCQCIKRGELHKFDLALQEGEDEFVKRRIYLTLERGRDIALRNLLRKVFIARGFEEAKPGEKPVRRTRVPVAEFAAAISLGSEEKIDNDEVECLLANMIYKGHMKGYISRQHGMVVLSKSGAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ27</accession>
    <name>A0ABR3VQ27_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play a role in fatty acid biosynthesis and insulin sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="367" mass="39773" checksum="56928DDDD7C98687" modified="2025-10-08" version="1">MALPVLPRGAAYIMLNAPARRNALSLSELRSLRDQLIKANTSPTTGRLLLLPPFKPSVLASLEQAHSRLSASSGPSPPKASPKLNLDANHTGTPSHQPPGQQQQQQEAAEEEDYTWLTSPMHFSHTRSTLPRVLVLASSPGPVFSSGHDLGELRTASSSQISETFRLCAEVMTLLRRSPQLIVGRIAGHAIAAGCQLALATDLPIAHERVKFRLPGATLGLPCSSPAAVVARRVGRARGWRMVALGEDWGAEELEDVVRVVKREEHEEGDREEGLVRALDREVGRTVDRLLAMSPQQSAMGKWAFWTQVGITGREDRGGGSDGLEDALAWTGRVMALHAKSEDAQEGISAFLEKRPAVWKSVAENQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQB2</accession>
    <name>A0ABR3VQB2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_370</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="468"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1843670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="558" mass="59523" checksum="577C71E75AABCA1D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQL3</accession>
    <name>A0ABR3VQL3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="149"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1844116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="378" mass="41397" checksum="1B18F0242798804A" modified="2025-10-08" version="1">MAYHLSQAITRPLRSRRHSPDLSSSPESSSSAGSATPPTDPAISPTSSSFLTSSVSSLWGGFMRRFSSEPSSASLTPTPHGQPHHAYTFQPDGSNKRKHLDSDTFSYPRSSTMRDHGRRRDRSESPMRPPPLEPVQLVGFADDTRPEARLLTQALAEEIRIMVPARLGIVDEWRLVYSLEQDGASLATLYDKCARYQGVRVGFVLCVKDLEGGLFGAYLSDRPRPAPKYFGTGECFLWRASVIPGSATTTTTTTTTTANGTANGTTQQRSSTPSNNHQQPQPQQQQPLSEKPQDQPHQQHSPSIRFKAYPYSGINEYYMLCEAHFLSLGAGDGKFGLWLDDGLERGVSATSQTFGNEPLSEEGEKFGVLGVEVWVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQL4</accession>
    <name>A0ABR3VQL4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="58697" checksum="B8D8EB61DF92121E" modified="2025-10-08" version="1">MPSINDLPTELLDAIVTALCGDHEPQEHPITCCVHRWYEWAPVEKQPPLLCDRQRQASLRSLCLTSRRFHAVTLPHLYHHLQPSSNWWRLAQTLALRPELARQVRSLRFEGKKQEPDDVDPWVWEDPHLRPLYEARRAEYLETCPEQLCWPGFGPAWQDGYEKKDDARRMTEFENCFETGHNLSLSLFTSMLPNLETLVATVGFAVAFRFNKPGSLPRLRHIHLYPDKYEWMIAVRRVLPRLFAAANESLESIILEYCSEHSRWTGRVYPDLRAFDAQRRLSAKEEALRKPASCKEERNSESREELGSDEDLDSDESSEEDGESEEGGQMAEQTVVQAQEEEEEHEEEDSAAEENSESEGEEGESENGGQGWVMGQQDQDQEEDDEDEHEEYPSGGPYSFICPRVAHLTLIDWTLHKSLLRHMLTSFPNVTHLHVQVLGPKRDEIYSLYNGFLYHQWSTLPELAEFFRRRSSTALKLQSFVFEPTHSYENWEWYCSEEEAKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR28</accession>
    <name>A0ABR3VR28_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="10" type="ORF">VTJ49DRAFT_2337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="9">
        <location>
            <begin position="71"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1844280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="302" mass="33040" checksum="33256FA25DB5B5A9" modified="2025-10-08" version="1">MPSGPGSTTGAPNAPSIGPARPDIDIIIITTTTMAPTCSCTTATATATNNDNNTNNNDHLVQSDDPNHPANLIPSLCAKFWTLGWVTGTGGGASIRNDDLVYIAPSGVQKELMKPSDMYVLSLEAQNGLADRRQRVYLRSPPGGRPSQCTPLFLAAFTRRGAGCCIHTHSQWAVLVTLLLEAEGPGKDREFRINNIEQIKGFGRGPGKTGNLGYHDTLVIPVIENTAHEEDLTEYLEEAMEKYPDTYAVLVRRHGVYVWGENVHKAKTQCESLDYLFQLAVEMKRLNLPWVTEIEEVKPRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR73</accession>
    <name>A0ABR3VR73_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF382">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045168517" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="691" mass="75723" checksum="78EB2CD25687C4AA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR78</accession>
    <name>A0ABR3VR78_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4928</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="798"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122047" checksum="21BECA7E1E91E261" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRC2</accession>
    <name>A0ABR3VRC2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="10" type="ORF">VTJ49DRAFT_854</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="189" mass="19700" checksum="C59CAADA50E4C9B1" modified="2025-10-08" version="1">MATHLPPGLSPDAFDAVTELTSIVLRLRASQQQDSATSSGAGGPTSTPAATGATSGGANLSGTTPLPTTNTANTPSGAQQPVTTTTTTTTTTTTTNPNNNNTSTSALPPLSLKDLPAATDPLRHKLQRARAAVRALADVQRELAQQEAELAGLEARRRAQAERLARAQEDGLQFVRCEEERGERMVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRH7</accession>
    <name>A0ABR3VRH7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1844300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="379" mass="41709" checksum="5FEA4C36475B2117" modified="2025-10-08" version="1">MAAPEVHHLFHAPVADHSFSADRKTLAVARDTSVELYTRVGNAFKLKDELKGHDKTVTSIDIAPTSGRIVSCSQDRNAVVWEPTPTGYKPTLVLLRINRAATFVRWSPSETKFAVGSGDRLIAVCYFEEENDWWVSKHLKKPIRSTITTVAWHPNSVLLAAGSTDAHARVLSSFIKGVDARPDPTAWGERLPFNTVCGEYMNRSAGWIHSVAFSPSGDALAFAAHDSSITVVYPSAPEQPPRAVITITTQQLPFMSLLWNGESEIIAAGYDCEAFRFRGGEAGWELLGSLEAKGQSAAADQREESALNMFRQMDLKGKVKDDTQLKTVHQNTITMIRPYEEAGGAVRKFSSSGVDGRVVIWTVEVLLAYWVSATVHNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRP0</accession>
    <name>A0ABR3VRP0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hxB</name>
        <name evidence="8" type="ORF">VTJ49DRAFT_2333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1174"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1215"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="7">
        <location>
            <begin position="651"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1844276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1308" mass="145108" checksum="44FCD19F50A85344" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRT9</accession>
    <name>A0ABR3VRT9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_62</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09533">
        <property type="entry name" value="SAM_Ste50-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="392"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
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            <begin position="306"/>
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        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1844383.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="488" mass="52983" checksum="77E3C61648DA7E49" modified="2025-10-08" version="1">MNFDSGTAYAESDADDEYERDMHGSSPTATDVETSPIDSDPPSAEHTPTTYGYRSTVDRLPETIISEWTAEECADFIASIGVQQYADRFLENEIVGEALVALHHEDLKAMGINSVGHRLTILKSVYDVKKAQDVPIEPDHYMPPTAEAEAQTTMATLKDIKHLVEQLRLRDERIALYEQDLRRLTEDFKRLREDVLPALRLVKDVQQPLPTVNSAQAYESTLSPPAPTPVSAGQPSAGLKRQYSTKKIMLGTTPKATSPSHLQTTHDRSIVEQALDPTSAAERAVMSSSHLAAMNGAAGSSTSPSYPSPNIPSPTSPPTGMMSGTTLGARSYRDPNQPTSSSRSAYSTDDHYSGASSTQTSSSSKTATAPRRMQTPAPETPGAASNASVEIFKSFRVSMDDPCYKVLPAALKKYQINAPWDQYALYIVYGNEERCLGLDEKPLILFKQLDKEGKKPMFMLRKTNNAPAADASAAPPAAAPYDPPGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V0U8_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">DUF3824 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">VTJ49DRAFT_6976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1835344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="75822" checksum="A0FB215EED9F9EA4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V160</accession>
    <name>A0ABR3V160_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="74"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="EMBL" id="KAL1835519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="80" mass="8916" checksum="E8ADF4380D5F9701" modified="2025-10-08" version="1">MGRNLNFSREAYPNTVIAPSLMGIFPFVQPYKTNTMRIGSRSTMARVALFGALLAQLQPVVADVFYTVTSYFVYSLSTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">F-box domain-containing protein</fullName>
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        <name evidence="4" type="ORF">VTJ49DRAFT_6301</name>
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        <name type="common">Soft-rot fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1835634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="889"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="919"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="948"/>
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        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="743"/>
            <end position="798"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="698"/>
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        <location>
            <begin position="39"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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        </location>
    </feature>
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        <location>
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            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1002" mass="108189" checksum="FF8833292028E97D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1N1</accession>
    <name>A0ABR3V1N1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000572">
        <property type="protein sequence ID" value="KAL1835664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01393">
        <property type="entry name" value="RecA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="328"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="382"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="382" mass="41545" checksum="923F84AEFB9AA95C" modified="2025-10-08" version="1">MDYHAIHGHDVSSFDLPSTHRLPTVSAAQALEDLEGGIQKGHVTEIWGAPGVGKTAFGIQLAATCLAQEGRVVWVDGFHRLPITRLRAVLGAVTGAQQDNGADADRLGDRFVHYTCPTLPHFLALVCRPTAACIPPGTSLVVIDCLSALVNHAFPKLPETRPAAEAKIKGPPGTVRRLQVLQHISSSLQKLAATRDLAVVVLTQCATKMQAERGATLIPAINASVWEQGISTRLVLFRDWLAQRGAEPWAVRFAAVQKLKGKDVMGTASGACAFTVEERGLVVVEYNDDTQPSAALACTPARKRKLERREFEIADSDDEYYDLDDDELPPMPSQWQGSEDILLGPKPDEDEPEEENALDKHDDDAEDEATRPSQETPLTEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2C4</accession>
    <name>A0ABR3V2C4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000543">
        <property type="protein sequence ID" value="KAL1835757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="451" mass="47834" checksum="826682A724234946" modified="2025-10-08" version="1">MVHRCPIRNFTWVQGTLDAPQGPHMRTLPCDVPYWQNVHRHGASSININRPICQANVCIPGEADRVILPRIHPTRGSQPASREDALAARLRSLRERSSNAAQPAVLEDGTGTEKEKPEGGVPGEASRAVTIQSEFGGSPRGAVSRTSSSSYRFAAPEAVIDEAAVDELLETLADEDFDLGEGEEGAESPLAGDDSGTQPEDLTRLLQSLRLGSDSLPSAREKATPGGNNGGQGGDNDDNEDDDDSDGEQMTREVEKILAQLGDEINSLPPPQSKAESQDKSDPGPAGIPANNPTPDMTTNITTDGDETTSPVALPNVPSTQPTNDDPFAPDQSIASRLAQLRGLGPLDALGLPSAPTFLPSDGGSPDNRSLLRSRTKYTDADQRGWCVVCLEDATVRCLGCGEGEEGGGGGDVYCARCWREMHVGPSAGYDERGHGWVRLDGKVGRPGVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2M6</accession>
    <name>A0ABR3V2M6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA binding protein Nrd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000550">
        <property type="protein sequence ID" value="KAL1835736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CID" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="502"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="78072" checksum="324C77B16E20CD18" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2S6</accession>
    <name>A0ABR3V2S6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000478">
        <property type="protein sequence ID" value="KAL1836030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="450" mass="48256" checksum="A90458E9350979ED" modified="2025-10-08" version="1">MIINGEKWACEACVRGHRVSNCQHSDRPLQHINKKGRPVSQCQHCRAMRKSRAAHVKCDCGEKTQKCVHLRPPLEGHKESCCCNHGGRCTCCQKREPKLDTVPESDSDEAAATRSRSSKSSTSARAARRRANTTSSEAALLSFDANGHHKPTYKHPKASHKVGPYQLNRAHSMTSATAAMRNRSMDDLYRAADSTSPGSGNGSDGAAANQAQQRRVVKSEAASPALEGSSFAQLNSQLPPLDLSGIKYPPYIPNSADFFGSFSDFEQPMFSAGLSAASVDWSHYEGLELASKTADFAPSNYSQAQSYGGFDFAGSETLPGMTTTSTSGEVSEVEDFLSNPLDDFDTFPAATTSGSGFGFGTAPATQMSDLFATADGLPSTLDMVDDLDIFVAKKDPTSKFLATSAEDQTVLATAPAFGTLSALDDDPAFWINEYAVPGLTESPPSFWDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2Y4</accession>
    <name>A0ABR3V2Y4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NUP49/NSP49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000460">
        <property type="protein sequence ID" value="KAL1836134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="47398" checksum="DA50FCFF573F810E" modified="2025-10-08" version="1">MLGRSASGPGGLSINTGSANLFGTNTSQPPAGGGLFGTATSQPAQSGGLFGTSTPQTQTGGLFGQSTTTGTQQQQQQQQQQQQPATGGLFGSTTTQQPQQTTGGLFGTTTTSQPAQTGGLFGTTTTTQQPAQTGGLFGNTTAQQQQQPSTGGLFGTSTTGGMFGTKPATTTTGGGLFGQTTTQQPTTGLTLGQSTTSQQQQQQTIPGVRIDLSNLKSTTRFNDLQESLQKEIAQIDEAIQKCIKEKEAIDAFLPSHGEQLSMIPTDVSFVSRKSEGAHSALSSDIVAIDQLRELVKQDADHARLSFKAIDNLKLPSQYHQAGLWSKTGGAGGAGAGTTGAAGGAAAADAQSNIDLISFFSRTADEMEDMMRKFEKNLTEIEVHLHGVQGGMLEQMQRVAAAQSKASAGQGSAADERVAELAAVLRDFEESILRVAGVVGTVKEGVTELQLKDFMGHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V385</accession>
    <name>A0ABR3V385_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000451">
        <property type="protein sequence ID" value="KAL1836181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="43246" checksum="64608A45A40C974C" modified="2025-10-08" version="1">MESLPTPPNEDLVRPQAIKKPQGHSKSLKTVPRALKRSSPHSHPPSPARESHPPHGDGRHKRVWKACERCRMKKTKCDGEFPCKRCKDDGLICTAGTRKKTEYKQLPPGYAEVLENTQFVLVATVQKLYAMVRNGDTWDLGEPELNDRGQPVVHNVAAKLGCLRPNNDLDLPVHSIFPEDEAGMAELARQLREHNAATATARAAAATGSSPSVLLSQSTTGRIDPTYQQYPHADSAASSSPASDADHSDFEGDSSNYRRSAFGATSSSSTLSMSPASLSLGEFDVSPPVSTLASSTGSFNAWMSGAQQQQQQQQQQRQEQQQQQIWMASQGFLDTDMVGNASGLLAGSGFGMKMPQNSAFSSSCRNPSGIMMGMADPMIYSGYDEDPLLRPLFANPANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3K9</accession>
    <name>A0ABR3V3K9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000430">
        <property type="protein sequence ID" value="KAL1836315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="161"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="292"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="212"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55774" checksum="3788E183B6877637" modified="2025-10-08" version="1">MYCQKCRTPLRLDSSLEDLNPAAYDLLVATHAQQEPGKPSVSPTPHSLDPSRKATYDQAVNNAPQPIFRRHAGASRALDTRGHPRDSSMSFIFLTESQIAPANSAVYRPNLQPLDDSSAPPGTSAETTPDNEDDAAAKSHEMERVTKLFEILSARSDIDHPVCVECTDVLLEELQKKLDATVRERDAYVAFLKDMQANAPTDDELKAREEALHKAKEAEAVTRKDMAALEKEKEALDAELRALEEESRQLDAEEEAFWRDRNAFASRLADFQNERDSINAKFDHDSRQLEKLQRTNVYNDTFCISHDGTFATINGLRLGRLASKPVDWPEINAAWGHALLLLVTVADRLGYRFEGYEPQPMGSTSRIIRYDQPSPASSSRLAAPGSRSAPPPPPKKHVLELYSSGDAPLGLTFIHRKFDNAMTAFLELVRQLGVHVHAQTAATGTPLSLPYVIEGDRIHGASIRLGVSQDEDWTKACKFTLTCCKFLLAHASNVNSPSHGRDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3P8</accession>
    <name>A0ABR3V3P8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000425">
        <property type="protein sequence ID" value="KAL1836346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52148" checksum="BB2D41C62ADBEBA8" modified="2025-10-08" version="1">MSAPSAAAAPAAPSNVPAQEEPHNEGSKLRTFISILRKFIGVSDLATVRFSLPSQLLEPTPNLEYWNYLDAPNAFVAIGTADDPVDRMLEVLRFWFTKDLKYAKGKPCKPYNSCLGEFFRCNWETEDDAPKIDTRALRGVLDTSESSSSSTPAPERLVPPGLGSGDARAASSVSISQASTNPTKPVRISYLTEQTSHHPPVSAFYIDCPEKGIHAKGFDQITAKFTGTSIKVSPGEHNLGIFITLERRNHETYQLTHPAAHLGGILRGALSVTVGDMCYITCPETRLKAILRYYDEGWLGRTTNKVEGIIFHYDPDNDDKHRIADVSEDDILVRLGGPWKEKIVFTLGPKPLNSHPPEKQITIIDIAPLAVAPKVLPPAEKQLPHESLQLWSEVTQAILSKQYSKATTLKQALEEAQREKARERERKNETWKPVFFEQATDKAGKPSLTEKGREVLRRAQKGDWSMEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V462</accession>
    <name>A0ABR3V462_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Grigoriev I.V."/>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V503_HUMIN</name>
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                <person name="Drula E."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5E1</accession>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
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        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="840"/>
            <end position="859"/>
        </location>
    </feature>
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            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="859" mass="94097" checksum="D9AE1E08B0C0CED9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5K5</accession>
    <name>A0ABR3V5K5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000391">
        <property type="protein sequence ID" value="KAL1836598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
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        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045123469" description="Peptidase A1 domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="63"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="518" mass="54813" checksum="3D11C603D62ED347" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5S9</accession>
    <name>A0ABR3V5S9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Retinoblastoma-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000328">
        <property type="protein sequence ID" value="KAL1837114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="574"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="70961" checksum="708B0F23464E5486" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5V6</accession>
    <name>A0ABR3V5V6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000324">
        <property type="protein sequence ID" value="KAL1837144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="508" mass="55935" checksum="A184CA002FCA7AAA" modified="2025-10-08" version="1">MVADTAYYDILGVKPTATELEIKKAYRKLAIIHHPDKNPNDPTAHAKFQEIGEAYQVLSDEDLRKAYDKYGKESARPSEGFVDPAEFFTSIFGGEAFKDWIGEISLMKDLTATMDITMAEEEEQEEAEAAAAAAAAAAEGKDAEFPGTAEAVKESLKTGQAGASSSEGRPVPTVVVENGTPDAPPPPQSKSPTPSGATTPTGGRRTQIPLRPALPAAPSDEVQAQEEGRESQDMKRKDKKSKGLSKEQRDKLAELERERAKVREERVNMLSGKLLDRISLWTETDKGKDVTAAFQEKIRLEVEELKMESFGIDILHAIGQTYMSKATALIRSQKFFGMGGFFSRMKDKGMLVKDTWNTISSAIDAQHTLEEMARLEQQGGEDWTEEKKMEYERRATGKILTAAWRGSKFEIQSVLRDVCDNVLNDKKIPLAKRLERAEALILIGQICANAKRSPEEEGDYMAFEQLVAEATMKKEKESKKKGKDKNKTDPATAAAEAAANDAPNVPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6C0</accession>
    <name>A0ABR3V6C0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000340">
        <property type="protein sequence ID" value="KAL1836996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="104"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="422" mass="47918" checksum="C16E53E5641C4AD1" modified="2025-10-08" version="1">MTTIACPLVPPTTVAGIKTGKEPVSEIARPEISWIPSYKVFKERVEKLGALYPNRRTTVPEGWPAQVEGARAWSGSDFASENEYIVYLSSEDIAEIEAGLAHFKALPGNLGPEDVNKDTFPLPNLKERLTEVSEIIHNGRGFVVLRGLQPEKYSNLDNILLYLGVTSYIAETRGMQDFDGRMILHIQAVVEDTKKDGKQPNSPYVTRAQPFHADLCDILTMYALNTAAVGGESYLASGAKIYNELARTRPDIIEVLAKDDWIFDEFFQGQYHTRPLLYSFPPHGPGFQFSRRPLTGAHFSPHHPSVPAMTELQAEALDAVHFLAKEHALELRLQRGDMLLINNFAALHARASFADDPARDRRRHLLRLWLRNEEKRWPTPPALERLAWEVYGEHEWRKERKVWDVERSPPELRVKHRRASCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6K0</accession>
    <name>A0ABR3V6K0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_4091</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000314">
        <property type="protein sequence ID" value="KAL1837250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="103"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="336"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1837250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114031" checksum="57BE0EC50F8CEAD5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7A3</accession>
    <name>A0ABR3V7A3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_4437</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000345">
        <property type="protein sequence ID" value="KAL1836958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="177"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="295"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="463"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="555"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1038"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1141"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1187"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1154"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1165"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1187"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1836958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1294" mass="139164" checksum="64B7EAD5D2D54606" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7G8</accession>
    <name>A0ABR3V7G8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000285">
        <property type="protein sequence ID" value="KAL1837527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="595" mass="64783" checksum="267A3196A6083F55" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7R5</accession>
    <name>A0ABR3V7R5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000260">
        <property type="protein sequence ID" value="KAL1837823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="68"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="526" mass="57577" checksum="21FBC833DB973FAB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V923</accession>
    <name>A0ABR3V923_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uridine/cytidine kinase</fullName>
            <ecNumber evidence="4">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_2810</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000222">
        <property type="protein sequence ID" value="KAL1838320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="910"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1838320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118314" checksum="453884DD0D64D2A2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V963</accession>
    <name>A0ABR3V963_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000225">
        <property type="protein sequence ID" value="KAL1838279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="499" mass="55482" checksum="3918937962A9B725" modified="2025-10-08" version="1">MDVSSNMGCPAPFTFSSCDGSSSALSSGHETPNRPAARRRRHSHFIQQRRKSIVNQIMDGEEGLLLKLDLFLTELEKRFEQWESYGEVTLDSSISAAFNTLQAVRTRCSHVSEEFMGAGRRRLHVMVETLESKYHEAMATAESLNEKAKVGIELLDGMLQEMEEQAAKLREKGLANAANAAESLMGEAHRVVDEGIERAIRAAESLEEHVQRAIARAREHGLIHYEDLPVPWRINPHILKGYRFSETKLACVKSAFGFSNELVNIWSHAIGLVLVLAVAFYFYPTSANFSMSSGADIFIAAVFFFAACQCLACSVIWHTMNSVADVSLISMFACVDYTGISLLIAASIMTTEYTAFYCDPVSRWIYMVATALLGAGGVILPWHPRFNGQDMAWLRVGFYVALSATGFLPILQLSLTRSFEDVLAFYTPITKSLLVYLLGACVYASQVPERWYPGMFDYIGGSHNLWHVAVLGGILFHYTAMQDFFAHAFKLAQDGCSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9D1</accession>
    <name>A0ABR3V9D1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000270">
        <property type="protein sequence ID" value="KAL1837708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF42">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="292" mass="31881" checksum="521DA76EDAA1B629" modified="2025-10-08" version="1">MGSQPPTSTPPPIRACLFDMDGLLLNTEDIYSLCANKVLAKYNRPPLPWSVKAKLMGVPGGSNGNVFHAWAQLPISREQYALEQAEYHAIHFPECQPLPGATELLAHLTGGGKGGEKAAKNVDGRRVRVALASSTASENFALKTSREAARGLLDMIPRNLRVLGDDPRVKPGRGKPAPDIYLLALETINAVLREEGTDEPPITPAECLVFEDSVPGVEAGRRAGMRVVWVPHEGLWEEWKDRVREVLAGRTGLVPELGDEHQLGELDDGWAEKLESLEGFPYERFGILGPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9K3</accession>
    <name>A0ABR3V9K3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000209">
        <property type="protein sequence ID" value="KAL1838515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <sequence length="490" mass="54115" checksum="161BF556A0D4AC99" modified="2025-10-08" version="1">MSSSEEKVGVENVEAAVSEQAKMAPVSADDFGFTEKEQKAIIRRIDRRLVLTVGALYCVSLMDRTNLGFANIAGMSVDLELIGNRYSIITLVFFITYVVFQPPSTVICRKIGPRIHLAMITILWGGVMIGMGFVKTWEQMTALRLALGVLEAGFFPSSVYLLSTWYTRYEVGKRNSVFYLVGCVASAFSGILAYGIMQMKGLSGLNGWCWIFIIEGIITVLLGIAGYWLLVDFPDSKRKEWSFLGAREKEWICARVDADRGDVTPQKFSLINYLKAGADLKVWGYAMIFFNTTTVTYALAYFMPVILMQNMGFSVGESQCLVAPPYAFAGIVTYATGWAGDKYKLRGPIILFNCILCMIGLPIIGWASSPAVRYFGIFLTTAGANSNIPAAMSYQANNIRGQWKRAFCSASFVSFGGIGGIAGSLVFRSQDAPSYKPGLYACFATTGLTMLIVCLLTLEFKRQNGKADRGEKELEAEGEENYEPGFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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            <end position="141"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1838292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="638" mass="70439" checksum="799F88C88229AF6F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAD1</accession>
    <name>A0ABR3VAD1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000199">
        <property type="protein sequence ID" value="KAL1838684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18134" checksum="861EC8CE8E524557" modified="2025-10-08" version="1">MFSIVQAIAAAEAGAYLISPFVGRILDWYKAATKKDYSKEEDPGVASVKNIFNYYKKYGYKTIVMGASFRNTGEITELAGCDYLTISPALLEELHNSSEPVAKKLDAAGAASLDIPRKTYINDESSFRFDLNEDQMATEKLREGISKFAADAVTLKDIIRAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAL2</accession>
    <name>A0ABR3VAL2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000191">
        <property type="protein sequence ID" value="KAL1838827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="191" mass="21060" checksum="EF3E2EC1AACCBEC1" modified="2025-10-08" version="1">MPNLSIASVSHIVQLWQSLFQATIAMSTFGGSITFQVIFQQVDGQPVEEDPHVFRFDYKDSRSFLAGSWAAFLIVLAISCIAAIALTIRRQETVEGFKHTFPRRWALFIVVAGWLAVEGLIVAFFFSSLAVTAYSNKTGWATAGFTVLCAIGTLVFWPALVSYVIQILCAPSLRRDCFLTSRSPVKRGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAU6</accession>
    <name>A0ABR3VAU6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="5">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="5">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000199">
        <property type="protein sequence ID" value="KAL1838682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="154" mass="15907" checksum="C8F9A6060C261E4F" modified="2025-10-08" version="1">MVKAVAVVRGDSKVTGTVTFEQESESAPTTITWDISGHDPNAKRGMHIHTFGDNTNGCTSAGPHFNPHGKTHGAPTDENRHVGDLGNIETDANGNSKGTVTDKFVKLIGPESVIGRTVVVHAGTDDLGKGGNEESLKTGNAGPRPACGVIGIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAV8</accession>
    <name>A0ABR3VAV8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000185">
        <property type="protein sequence ID" value="KAL1838925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="81496" checksum="460946162A3E4A69" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBA5</accession>
    <name>A0ABR3VBA5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000214">
        <property type="protein sequence ID" value="KAL1838443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="102"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="602" mass="62925" checksum="2B0C09100932EC45" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBD5</accession>
    <name>A0ABR3VBD5_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_2641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000212">
        <property type="protein sequence ID" value="KAL1838473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="54" mass="5939" checksum="7D3F3CC116CA9FE3" modified="2025-10-08" version="1">MSDAPKDTKPVVDPVPPTNPEEPKKKKDSKDTEEPKDTPETTETKESNDVSIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBV6</accession>
    <name>A0ABR3VBV6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Initiator tRNA phosphoribosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1839197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
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        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="2">
        <location>
            <begin position="366"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54950" checksum="7843CB6B2C75D259" modified="2025-10-08" version="1">MPPPTLDQLLFPSQSNDFGGGAQKLSHLLGDLRRADLSIPNRLRSVCEDAAFVADVADALPGLPLIANERCGSWYVDPARKKGSAYFKSTDGHTGQWKFSLRRLNLHLLGLVGEFGGCIIVDSTRRGKRMPDALSKTIPTWCAVLNRFLFPSLPSSAHALHTPPDTVSASESAQMAALLPSFVESFLSLRPDDLVRSACNGTPLPTKPLRPVWITQDDREHLDGCGTTSDGGSEYEGYGYSYVQGAGDDTENWAHELTPGLFWRWRRELLDAAAVGEGEVEGLIRELVAREKAEKEEPAGGDGEPQSGDGRRAWERVREVVPGKRVYVGDLAALGGAATWEREGVCVVVLREKVTPSEAWVKGSRRVEVGLGKSKAASRALRDALPVVCEFVLRYLRERWQQQQQELEEVTEGKSGRRGQPAVVILCESGRDLSIGVALAVYCWCFDDAGNLRRKEDGEVSFNKTSIRVRLGHIMTALPDVNPGRATLQSVNSFLMDWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC68</accession>
    <name>A0ABR3VC68_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000165">
        <property type="protein sequence ID" value="KAL1839302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="77"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="342"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="605" mass="64838" checksum="386266A5FFD86FC7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCA9</accession>
    <name>A0ABR3VCA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_1465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="28"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="229"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1839490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="493" mass="54092" checksum="4D1275DDD04E729D" modified="2025-10-08" version="1">MVGLGPKPPPSRKGTGLADAPKDLVNEIKHLEELFTIDTAKLKEITNHFVNELAKGLSEKGGSIPMNPTWVMSRPSGHETGSFLALDMGGTNLRVCQVTLTEQKSEFDIIQSKYRIPEELKTGDADELWEYIADCLLQFIETHHGDVAKIEKLPLGFTFSYPATQNYIDEGILQRWTKGFDIAGVEGKNVVPMFEAALASRGVPCKLTALINDTTGTLIASAYTDPKMMIGCIFGTGCNAAYFEDCGSIPKLAHLNLPPDTPMAINCEWGAFDNEGKVLPRTPYDITIDRDSPRPGQQAFEKMIAGLYLGEIFRLVMVDLHKKPSVKLFDGQDVSKLFKPYSLDSSFLSAIEEDPFENLSETLDLFQTKLNINPSHPELELIRRTAELIGTRAARLSACGVAAITKKKGYTSCHVGADGSVFNKYPHFKARGAQALREILDWPEKANPKDEDPIEILAAEDGSGVGAALIAALTLERVRAGNMHGILHPENFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCD7</accession>
    <name>A0ABR3VCD7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000153">
        <property type="protein sequence ID" value="KAL1839504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="152" mass="15431" checksum="7A01BA376779AF6B" modified="2025-10-08" version="1">MSATEEKNCPVVGTTTTTLPPSHPDIDLSQPGQKCPVVGATTDHHAGVLHKHPAVPIPEGRSASDASACPVVASKLNNKPEETAIDATLCPVVGTATTTLPPDHPKTEDKADDAVCPVTKATVGHHKGKLHGHPDVSAAGEGAVCPVAGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCM7</accession>
    <name>A0ABR3VCM7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_1471</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="201"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="552"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="867"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="925"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="963"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1839496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1099" mass="120218" checksum="BB71B9F768938B3C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCN4</accession>
    <name>A0ABR3VCN4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="86" mass="9723" checksum="9504FD6560CE533F" modified="2025-10-08" version="1">MTTAEAPKPQTPMQQELEQQREQQDGVVVTRQPASEPRMDINNAQDENLRLRGGARICCCDVGCHAHNCHPRMWCSCCNGMFTFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCT9</accession>
    <name>A0ABR3VCT9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000145">
        <property type="protein sequence ID" value="KAL1839685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="183" mass="20414" checksum="86A11B5A60DEC73C" modified="2025-10-08" version="1">MSQTIGATRLAYSRVWHHISAAAPHPRLSTVKSPPEAVTPPSLGRLASRIATLLMGKHKPIYDPSTDCGDYVVVTNCAALYTTGKKKWRKTYYRHNTRPGSLKSITMDVLMEKFGGAEVLRRAVSGMLPKNRLRDKRLARLKAFEGDAHPYKQNLIRFGGKVVGTEGWEEVAKAVRQTDRGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDD2</accession>
    <name>A0ABR3VDD2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1716</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000168">
        <property type="protein sequence ID" value="KAL1839238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="74"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="281"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="518"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="401"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="670"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="914"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110990" checksum="ADC7AA74C1B070C2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDD9</accession>
    <name>A0ABR3VDD9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="97"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="388" mass="43060" checksum="29F82D1D222EB6B0" modified="2025-10-08" version="1">MAEAAVAAELTSAAGLARNRVIQQLPLAKRIKYSVGAFLLSRLFRGLTVLLDGFDQLTGRRRDSYPDIIKSYPVRKNLTVRIFLPRSAPPNTKLPTLLTIHGGGFMIGHPADNDAWNRHFSSTHTFLVIALDYRKSPTSTFPTPIHDLEALIACILSDSSLPLDPSRIAIAGFSAGGNLSLSVSQLPSIRPHIRAVVPFYPVVDLSEPSAQKLLTRPYKPHLAGFRGSSVDYLKRLTGMFNWAYLDVGQRTDDPLLSPFYARPESLPGNVFFVACELDMLAAEAWRMACKLAGRPVPGDHDVVGTKESVAEPGRLITEGDERYAWEEVLEGGERRYRWLLVPDTTHAFDQEGMWQMIKDPVFVEDAKEKTRLVIDLVGKWLLDGPLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDZ8</accession>
    <name>A0ABR3VDZ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septum-promoting GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000129">
        <property type="protein sequence ID" value="KAL1840050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36897" checksum="AD74BA91C9E68A07" modified="2025-10-08" version="1">MEQDPFQVPGPAISDPFVAPAPAPVPNPALTSATETFPTESHEDTGGGTDNTTPQAVAHDHNGYQEQPIHAPPLDHGDNAPRNYYPTDNTDGEPTARYATPPVPGPSISRPPSGLSGHNAPAYATDQASRAGSNGAPAEPQQNSGRNHVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPVLVGTKYDHFVNLSREEQEEISNQARRFAKAMRAALIFSSTSHSINVQKIFKIVLSKAFDLKCTIPEITNVGEPLLIYQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VED3</accession>
    <name>A0ABR3VED3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF15">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045280730" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="62"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="511" mass="55636" checksum="AF0BBC9DC9B04423" modified="2025-10-08" version="1">MRFSPSHLLVAALGLGIFDAADASCSCWNKGLEACLRTKRIPYKVKCDADWADYSRTPNLRLPFKPAAIALPDTPQQVSQAVRCAAQNNVKVQAKSGGNSYGAFSFGGKDGQLTIDLGKFNQTLLAADGVTAIVGGGVRLGSMAIDLYNQNKRAISHGICPSVGIGGHSTHGGWGFTSRAWGLTLDHILELEVVLANGTIVNASPDNHPDIFWAMRGAADSIGIAISFKLRTQPAPEEVINFTYEFRSVVDSVDVAVSTFYALQSYISNSTLVDRRLSFALQTIANFAPNSTNLHKAFLVEGTFLGSLAEYNTTIEPFMLAGLPEPTQRHVESNGWLESLAPLSPTGTLDTTSLFLDFFANSVTIDDPGMSESALRSYFTYMLEGPETPTSYLSSMELWGGADSQINQPDAKGTDFAAFPHRNVFWTAHNLARVGPGEKFPAEGITWLNGLRKILIESAEVHTAAYPNLLDPTLSRYEAHHVYYGQEVLRRLKGIKRKVDPGKLFWNPHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEP3</accession>
    <name>A0ABR3VEP3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000124">
        <property type="protein sequence ID" value="KAL1840163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="7">
        <location>
            <begin position="219"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="489" mass="54543" checksum="5BE25986DF49C834" modified="2025-10-08" version="1">MSATLYRLAGRSARRACTAATSAAVRRSTARPFSVSVLRRQAEPHEYQGTRIVPTGPDFSPGTGLSELESQLQLPNGAAAGLSADSASGIQKQRDEGVEDRKVRHYTVNFGPQHPAAHGVLRLILELNGEEIVRADPHVGLLHRGTEKLCEYRTYLQALPYFDRLDYVSMMTNEQCFALAVEKLLNIEIPDRAKFIRTLFGEITRILNHLMSVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVHQDIPLGLLDDIYQWATQFGDRIDETEEMLTDNRIWINRLKGVGVVSAADALNLGFTGVMLRGSGVPWDIRKSQPYDAYDQVEFDVPVGVNGDCYDRYLCRMEEFRQSLRIIHQCLNKMPAGPVRVEDYKISPPPRSAMKENMEALIHHFLLYTKGYAVPPGDTYSAIEAPKGEMGVYVVSDGSERPYRVHIRAPGFAHLGGFDHVAKGHLLADAVAVIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFI5</accession>
    <name>A0ABR3VFI5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000105">
        <property type="protein sequence ID" value="KAL1840614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="673" mass="73791" checksum="FBE0DFE709B271E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFP9</accession>
    <name>A0ABR3VFP9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="5">
        <location>
            <begin position="96"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="4">
        <location>
            <begin position="418"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="3">
        <location>
            <begin position="576"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="838" mass="94976" checksum="01578A458706ACB9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFQ7</accession>
    <name>A0ABR3VFQ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000106">
        <property type="protein sequence ID" value="KAL1840604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="90"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="589" mass="63363" checksum="960985CB3E6873E6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFU2</accession>
    <name>A0ABR3VFU2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000132">
        <property type="protein sequence ID" value="KAL1839986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="231" mass="25699" checksum="A83A7A9AF4741E68" modified="2025-10-08" version="1">MTSTAPEKDKSKTHKLSLKGSAKLVAEFFQYSIHTILFQRGVYPAEDFTAVKKYGLNMLVSSDDQVRAYIKKIMSQLDKWMVAGKVQKLVIVITDKDTGEHVERWQFDVQILSKPKSSKSSSSKSRSTATSAKDQENDSSKSAETTKTEAEIQSEIAALFRQITASVTFLPQLQGDCTFNVLVYADASSEVPVEWGDSDAKEIVGGERVQLRGFSTQSHKVDTLVSYRLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFZ3</accession>
    <name>A0ABR3VFZ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="71"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="309" mass="34483" checksum="62868AECDD5CA724" modified="2025-10-08" version="1">MSYQQMMQHLEETCAPDEKEFLKDVVNLEGTPDDYSNIYVARSTIDALESNLILSIQRASEFEYGVLRNNRVTGALLYGPPGTGKTLLAQAVAKKCNLNMLCISPSNIYSKWWGDDAKAIRGAFGLARKLHPCLMFVDEADGIMGKRKDLDQKFVRSMLSEFLREWDGAAEVEDRQKNPFILLASNAPWDIDSAALRRAPVRIPVPLPTEAERAGIFGVMLRDEQLAPNITIAGLAKATEAFSGSDIKTLCVAAATRCIQEQKPNHRGAYERRVLGRQHFVFALHYVKASTLDAEMAKKMEEFKTTGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGR0</accession>
    <name>A0ABR3VGR0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000105">
        <property type="protein sequence ID" value="KAL1840626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30757" checksum="4D3FB2A74E3FB2AE" modified="2025-10-08" version="1">MTEPCRACGDPLVLTLDPDDSSSEAECHSAHETTTVPDDLHLPCNCHFHWPCLLDQSTSILSSLTCPSCNQSLISGGASSSSSSSSPPQPQILTTYTNEGGVQPSLDIYPTLLEESFLSSHPEARPARAFHTMTAEGDTQGMLALLADFSVSYSDGISDQEAVPNPDEAAQQRQQLLVWRDPLNNHRTALHVALEAKQEEAVWLLLWVGSGIKSEEFPEAVVSAARGNGVPRTAEELSAEGKGLAQEEDVRFIKDGEGKTPEEVCLQLGDPWTRLVEGGLFTAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGZ4</accession>
    <name>A0ABR3VGZ4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="440" mass="49337" checksum="D2D6DBA4424F8D8F" modified="2025-10-08" version="1">MAGLIPLMLASGNRTSFIAPTQTSRRRQSSHGAPSPSSTPTTPTTPTFPAARPKPVKRLSLPAPAPAPIVVLPFTKAEWRKCIAEVKRKYFGKRYRACSARCLEVLDGIKDHSQIEPIYLIYLHFYAATSLEICARPLPSNGPQRAAMLQQARTHFDRASELIDAAEESVLQKFRPGSVSSSRGSSCHSPSNSISSSRAWTPETRVSSPTESVCSFDDLPIAKQPPPKRVKKVSFSLPRDEEPLDIAPEPIIRPDSPTLGFEDYFFIVPASQPESPSRFHEIEMPLETIPEHHEEELDCIPEETEEEQENHHDEDDENSYAIAGAVARACEHLATLRAQLARHSNSLDQLLLLQQQQPQKQQRQRISLLPSPRSPSPFPVSLPSPTNAPHQQQLQPIKEEARALDRQARIERLRKSGWQRKRFDARRYEELAETALAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHA1</accession>
    <name>A0ABR3VHA1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="746"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1117" mass="119675" checksum="4BC2DE7B762E2AF9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHB7</accession>
    <name>A0ABR3VHB7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="318" mass="36632" checksum="8B7D5B53780301BE" modified="2025-10-08" version="1">MLRLDYHNVLIHSVLTERFSGAPPVSIDQTVSDFDGVTFHISTPETKTKILVSLQIRCFKDLQRYGADEVLNREYGPYVVPPEPGYDFSILIDLENLPEEKEARDDLAMKVALLKRNAMAAPFEQAYQEYYQLKQEAAKFTSEEAPQGVREGGEVKAIHYREEEAIYVKASHDRVTVIFSTIFREETDRVFGKVFIQEFVDARRRAIQNAPQVLFRNDPPLELQGVPGVKNTGSGEIGYVTFVLFPRHLTPQRMPIVISQIQTFRDYFHYHIKASKAYIHSRMRRRTADFLQVLRRARPDSEEKERKTASGRTFKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHG5</accession>
    <name>A0ABR3VHG5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="434"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="800"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="978" mass="109793" checksum="BF5E802350D031A6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHY2</accession>
    <name>A0ABR3VHY2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7024</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="248"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="749" mass="83982" checksum="585B46F19AF8D907" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIV0</accession>
    <name>A0ABR3VIV0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="408" mass="45091" checksum="7D0CDBFB0E39D992" modified="2025-10-08" version="1">MATNGTHKVKVAIIGAGLTGLLAAHGLRKNGFDVAVFEREKYHGERLRDWTILIHWAMPLFTKLLPEHLVEKLPEALTNANLTFDASVESISAYNGVTGERLFTNPTPGARRVSRQRLRALLVKDLQDAGVIRWNKHLASLEEQGEDGPVKLSFEGGETYEADYVLGADGVASKVRELLFRGDEAAKPQYSGYYFATAIPKYGDAAKVDAVIKPHPVATIIFAKDSVGGCGVMHAHPPDDKSQWSTFWVKIWRKSVLQVPEDATYGQKALDFLRATTKGLAEPFQSYIDWTPDGSECYINEMRVWTSQPFDNRGGRVTLAGDAAHAMLLYRGQGFQHAILDATQYLDALVKIRDAGAKPSEVIAAYDKDMVERGEKAVTQSLKEAELSMDLNTVNQMLMVRKGHGKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIV7</accession>
    <name>A0ABR3VIV7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046734894" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="109"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="455" mass="49473" checksum="00127610AC1C5940" modified="2025-10-08" version="1">MLSMTSILCAALAAVSSVAGLATNLPTEAFRDAPPGITYSMAKPIQKWKSTKLAKAAPQNVQVLRPVNRVHTERFNPRSVAAILGSHQRLAGGSGYQNITSTTALGTQYSVDAQFNGHPLSLILDTGSSDTWAVAKSFHCIDYSGQFLPQDICGFGETYPESFQYGRTEPETHLFIQYGDGEIVTGPMGFSDVTLGNITVKKQQVCLANTTYWYGNNQTSGLLGLAFPSLTNAYLGDVNEHNWDNQVLYSPLFTSMVTQGLVDPVFSIAIDRNASTGMLAFGGIAPATGLDWSRTASLDMVVTNVISLPETAYQYSFYTVIPDGWYFDKTTNTKKVPYIVDSGTTLNYLPSRLADAINAAFDPPSIYLWTYGAYFTACDAIIPDVAVILDGIKFTLNPVDLIYRNLVDPLTGLCMTAIADGGEGPYILGDAFMQNALVVFDVGQAKMRFIPRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIX4</accession>
    <name>A0ABR3VIX4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="7">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="359" mass="41062" checksum="F7B284F0C1C168CC" modified="2025-10-08" version="1">MNVVKKADSDFWKLPVSKVDKSGNPEPRAAPLFSPQRLPVRPQLQWGHRYPEPPLRRCGRSRHGDGHRITDMAKSIQLKEEGNRRFQAGDYAQAEALYSQAIIADPTNPALYTNRAMARLKLSQWDSAIADCSECLRLSPNSMKAHYILSQAHLALRAHDDAVHHALRAHALCIGDDANNNAAKTSNQNSLATITAHVLRCKKERWDHLEKRRVRETSELEAEVLELLARERERAVRDAEENGLGEAGRKEVEEEWDAKAERLREVFERARPKEEKKRRVPDWAIDDISFCVMVDPVVVSSTTKTGKSYERASIVEHLRRHPHDPLTREPLYISELRPNLDLKQACDEFLEENGWAADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIZ5</accession>
    <name>A0ABR3VIZ5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045516741" evidence="1">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="193" mass="20456" checksum="6CCBBA2DF24D8D83" modified="2025-10-08" version="1">MKLSSVLACLVGIVSALPSSSPVAGDTIKRTTRPKALINEMRSLGSAPEGFAMTVVTPTVLQSKAGLAKLPSSLRRRQSVPGPADFFECRDSTPRPASADCKFIVDQLLASDDEFIIAANSCLAFSYKTCQAFFCSLCETLLTSTQFIGGQLDTVDALCVENGQAGTIVSEDAPQWDAGFTYTGQPVPTFDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ32</accession>
    <name>A0ABR3VJ32_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_6902</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="62"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="281"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1841592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="55288" checksum="82B7779D1B52373C" modified="2025-10-08" version="1">MPPTISTTAAQPQPPFPFTSSPAIPPQTATLPTTSAAAPTPSIFGLDALFHNPVFAGGIGLAGLGAAAAFGRRALIAGAGLLRRQLLVNIEISKRDPSYNWVLAWLAQPRDNRGFLASRLTRLRNLSIVTTTKSLNPRAAVPEGDGGGKIHADFRVQPGFGRHIVRHAPGVYIAVNREKAGTATTATGEPHETLTLTMLWMHRHVLADVFTQAHALAQSFQQGKTVVYTARRMEWAVLGKPRLKRPLGSVILDEGVKEALVKDVKDFLAAQQWYTDRGVPYRRGYLLYGPPGTGKTSFIQALAGELDYSVAMINLSEVGMTDDLLAQLLTQLPEKSILLLEDVDAALANRRQRDPDGYSGPTVTASGLLNALDGLAAGEDRITFLTTNHIDRLDPALIRPGRVDMMVRIGEATRYQAGQMWDRYYGDIDEDHSGRERFLKRLDELGLFGGDENNPEVPKRHTSTAAIQGLFQFHKGDMEGAIENADALIPRTFEPEKTPVEATIKAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJE8</accession>
    <name>A0ABR3VJE8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000073">
        <property type="protein sequence ID" value="KAL1841503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="320" mass="35389" checksum="3D49D5B722F8925E" modified="2025-10-08" version="1">MLLPSALPCDSSHTQPLTRLQAALFASPPASPPQLSTQTAFGSLFSTCRSLQSLLNNPAPAPTAAQQPPQQQEPITPPLAHAQPPLKLRLRSRKADTTSATLGDHGVARKRVVKRTAAVAHQQHQHQQLARGVNKRRRAVDSDSNNTTASHDDDNTDTEQHHETQDHDRHTTAPHTPERSRIAPEVLPLGLERADYHSLHSSFSSSFSSSSDGETQPPSFSLADNNNSTRTRLSRSHQHPGTDVVVETDGELWSTEEDRILVELVLEKLKLTKSDWQDCARSLGKDRNSVGRRWKTLMVNGDVGLKRACLRRPRVCGTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJW6</accession>
    <name>A0ABR3VJW6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045791577" evidence="1">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="279" mass="29464" checksum="EC6F7629A0542F77" modified="2025-10-08" version="1">MKAPTLTVLLSAAAAVSASPITIEERQNSGVGTGPFAPAGYYTTGSLPRHTIYAPRNIPPGAKLPVMLWGNGGCSADGTGQAPFLTQIASHGVLVIAQGTPRGGGSTTAQQMTEALNHIYNNAGRPGSGFEQVDASRILAAGWSCGGIEAYAQIWDNRVSGVGVWNSGLLTNYTAARDFRKPVFFFMGGPSDIAYPNGERDYNGMSPGVPKWKGNLNVGHGGTYTDYNGGRFGVAGSYWVEWLLRGNQQAASYFTGDGAQRDGWQVVRQDLDKISVTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK44</accession>
    <name>A0ABR3VK44_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_5650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="211"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="57102" checksum="5718E52E29AF2B91" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKB5</accession>
    <name>A0ABR3VKB5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="71842" checksum="7475D6176B65CE20" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKK3</accession>
    <name>A0ABR3VKK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha and gamma adaptin binding protein p34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="41111" checksum="CF759B27E2545AF3" modified="2025-10-08" version="1">MSTPSKATEISNPRRILAVSLADSAHHLSDFIRNLTGTAPTPALPQSDLTDTTTTTTSTTTATADQGEETQEQQQQQQQEPTLSGTTHPLPLQTPYYTASIPVWLDLISDNHEWARSFLAPEAKEVLEVLGGVVVVFGIPPPPLTASSPPAHSSVTCSREKARELITQVGRVVREGLGGWEWDGVGLAVGVSSHGYGSGGDGGDVGDGVLDEWEDLCAEWGLEFVHISAGELKASSSSSSGDQKGKEQKRNAFGERVGMARVLEALQANDWSGGGLGGSGDGDEGAGQEDDDDEDDDGDFDPSKLDFGFDKADFEGLRKAIWAGSTGNDDNEEEEGDIGEEDVERLERMMRKLQAVRDATAGLPEDQRKRMAARAVGEVMRELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKY8</accession>
    <name>A0ABR3VKY8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="269" mass="28485" checksum="DEC77E5555097429" modified="2025-10-08" version="1">MASSPAVTFSQSPPPPRPSTHSHPPRSTRPSSPGTSALPYRPRSDNTQPSAAPRTSQTAPPNSNSAAWGHPPALTPASPRPISEVGVNHYPGTTGPVKTNTGPGIDNKFPPQHHPQQQQYQPYYQYPYHYQQPPPAPAPLTTALIQTIPANAPLSSTRAAAQAALRELLSLRRQRAMLLSVQAQTQPNGVDPLGLGSGSGSGGGGGGGKAGHGSHERGNLQALRDVEERLSAQHRAVVQGLRQLQGRVAEVARRAEGTRWRRFVVGGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL50</accession>
    <name>A0ABR3VL50_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">VTJ49DRAFT_5276</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="45"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="283"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="540"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1842428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="652" mass="72450" checksum="821BFC1CDE64F6BC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLU4</accession>
    <name>A0ABR3VLU4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="171"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="609"/>
            <end position="732"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="405"/>
        </location>
    </feature>
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        <location>
            <begin position="543"/>
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        </location>
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            <begin position="954"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="1035"/>
            <end position="1063"/>
        </location>
    </feature>
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            <end position="75"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
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    </feature>
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        <location>
            <begin position="1035"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1366" mass="148889" checksum="CBA23D350DE44700" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
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    </dbReference>
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        <property type="entry name" value="Dicty_CAR"/>
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    </dbReference>
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        <source>
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        </source>
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    <sequence length="546" mass="60126" checksum="7E7D349CB163D834" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM92</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Conant G."/>
                <person name="Drula E."/>
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                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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            <begin position="103"/>
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        </location>
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        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
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            <end position="131"/>
        </location>
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            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="300" mass="32845" checksum="6F4D3AB9C180CA60" modified="2025-10-08" version="1">MALALLSYTLQAVGAIIQLSLNALGFAFVPLFWTLRTLFSLVSAILGLVIWPFLIPWRRIIIYFACAIIIGAISGLLVGFLTLLITRILQAFIPFLRPRARPPNRSNHHRYNKHKQSPPSSSAQVTPTDPSASPPHNGKPSHHHHHHHRSRSRSRSLDRDRDHDNLPYDSPSTSPSLSLSATPSEHDYDADDADATTTTTSSTKTTRRSSPRSPTTTSPSSSSFSRRGITSSTTTNRYPYHQYQRQQTYTSSPSSSRLGGLGGLSSSSSSSPGLSRRSGSRTTARAGSLVEDTIHEESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMH0</accession>
    <name>A0ABR3VMH0_HUMIN</name>
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        <recommendedName>
            <fullName evidence="13">Rad4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="583"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="642"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="712"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="883"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="772"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="108006" checksum="36DA22AF63689987" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMK5</accession>
    <name>A0ABR3VMK5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045713500" description="protein disulfide-isomerase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="383" mass="42185" checksum="149174F3C2618F2E" modified="2025-10-08" version="1">MLWIHIRGILPLLLSAPTALAWDHSSTSEIARLLDAGEPVLVAFVQPDEPASAAFEPEWLSAAESAGAGQHLLSVDCSAPNADCKITPDRVTYPSIFLLEADKPAVQYRGPRRAAAMLNFLARRTRPLITPSADANLSLEEELAAYRSATADETSFIAFLPGPADNDRRAAAVFEDIAWRYRDEFSFAAVSEASGKLQQGLKPPFVMCWKRGDGKGEVLDLRVEGIEELEKWVQKTSVDVVAEMTVLNRQRLLDRGLPMVYLFASTASERQSLRNELFGFARQHRQELTSVVVDPFDFPDLMGQLGLDSDVLPTGAIHDISGNKIYRFPKDKAFSGESIESWVSDVYEKHIKPHSPTTAAEDSHPVGAAKSTPNEQGDKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMK7</accession>
    <name>A0ABR3VMK7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047443840" description="NAD-dependent epimerase/dehydratase domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="233" mass="24747" checksum="E3E960CAE1C34AFE" modified="2025-10-08" version="1">MPSTLVIGSTGLVGSFILSTLLADSSVSAVHTISRRAPKSTGPTLHATVEADTSQWTSKLAAIQPPPDTVISSLGTTRAQAGGIANQWKIDHDLNVELARAAKEAGVKRFVFVSSAGTRGLLGSLAPYSRMKQGVEDTVRDLGFETAIILRPGLILGEREVPHQGGPLMTGIARGMGRWFGLGLQDKFAQEAEVIARAAVHAAKIAEEGKAPAKYWVLEQGDIVRLGRTEWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMP8</accession>
    <name>A0ABR3VMP8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aprataxin C2HE/C2H2/C2HC zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000022">
        <property type="protein sequence ID" value="KAL1843179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="98"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="9">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34523" checksum="D72009CF921C0B2C" modified="2025-10-08" version="1">MAGKHPKPELAEDEQDFTHQPDEPPISTAESPDSMPSKPKPKKEKEIRNAFTELMAPKPKPIHQPSPSMASKASQVKKNGIWRGALGEYTTHPERFPPNVVIRYTEHTVLIRDTFPKATVHLLLLPRSEEHSLRHPTAALSEDPEFLEIVKREADEAVRLAAAELERKVGSFSAANKARYEAMARGDPPDSWPRGRDWTKDVRVGTHAHPSMAHLHVHIISRDMHSEKMKHRKHYNSFNTPFFVPLGEYPLAEDDVRRDTGFQNGNLMAELRCWRCGREFGNRFAELKRHLEEEFEAWRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMW3</accession>
    <name>A0ABR3VMW3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cyclin-dependent kinase</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="92"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="423" mass="46099" checksum="894C71FA5F82A884" modified="2025-10-08" version="1">MADAGDWRRSLTASERYNNIQKLSQAVKAAGLTQNAFAIEDEAYKTSTSREQYDAAINLSIPSSEPTPKPPTTTDQDDEDSPSSPGTTIGPYQNCHYIASGVTAAVYRSNQHALKVIVETRNIAPHNPNLEAKLLTNLRAASAPNIIPLLSTFHDHDQHLVLVFPYMPFTLDHLLSTHRAHNSSSGTITTPLPSSTLQVLFTALFRALSHLHSQGIIHRDIKPSALLLSTPSPTPTHPGEIYLSDFGTAHHLIHSPPMSNEPCDAKILDVGTGPYRAPEALFGNRAYTAALDMWSAGCVLAECLRGGEPLFESRPAHEDGNQLGLVLSIFKMLGTPTEETWPEAKGFRTPPFEMYRVFEGRVEREGWREVLLGSSGGDGGEWEGWVGLVEGLVRYESARRVTAAEALDLPCLKGADTDAGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN19</accession>
    <name>A0ABR3VN19_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="509" mass="55617" checksum="1A6D8506EEAB159D" modified="2025-10-08" version="1">MAKRNCDALTADDYDEPVSISNKRRREQPVEAPKPDPTYGQRAAFPGLDGDDPVPFDDDLEFEESSDALAYLRAVRQEAHSVPHVLVAPKAGPQLPAHLQPSDPDFAGIDRSIYDDGVGDSRGYYHDGAYTAAPDPDSPSSTSSINGAEVDYDDSDDLTSPDRVALRNAALRRAYYTSLTARFEHLRSILHQIPPQSAIEALPPTHDACVPPFGQNSSTFRIWSRRLRTTDPLPAQVAAMDRHAVLRVLRVILGGKFLRRGCELRERTSRWLWALLARLPDRGELDYAEVGWVRELGKRAVLMMVSMAQMEALREEVDDLDGEVVEDEEENGSTEEKGEGVGHEVVDEEGEEEEEAGVSSAAAAPKDVEEQQPTEEATAQPKPANANAPEPTALAAEEEDEGGEMDMDIDEGELTDTDGIAVPNGKDIASTAVASDLDAAKARLLAQLEDVSSPGEKAGGPWEEEEAAMSAEERARLNMRATLNMILTVAGEFYGQRDLLEFRDPFPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN52</accession>
    <name>A0ABR3VN52_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55148" checksum="4B94287FAF686C2C" modified="2025-10-08" version="1">MDSLPVELVRLIFEYCDAPSVRTLRQAGARYAEIGYEFLLPAHFDAVEWRDDVWRLRSIAGHDRLRGEIRSVTFNFARIDEYDARHATFFQHWLQDPEERHQLLQDAWSRYYEREERARRLPPVHARTGDLEEAFRNLPNLRHLDVTFTRCPYSDIPVLRDVFGVPSCRALDRALACKNLNAVVSAARHAHPGLDSFSIDQLPLELFRLPDDRRLWFDCARSFASLSRLRFVIDVPSSLLPSARFRAVNGLGHVLQQATNLTHLSLAFQMSHAPAEKFPLSLQGMFGGGSGANSPTRAATPTTSPRTGAVGDPVFPRLTDLHLEGVSLAERDLRAFLLRHAATLERLRLGGRGLARPHEPPLGGVHLHEGSFRGLFSALQGRLPALRRFHMEGDAEAGDFRAPSSVNHREVYLFRPVADDEWRPVGGDEKWVEKTGEEGNAVGVDGKTLLLLRGRGGGEGGSGGCVVKVVDSRALERFLVEGVGEYPRLGKVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNC3</accession>
    <name>A0ABR3VNC3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="100"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="513" mass="56691" checksum="1162DEA51D709648" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP01</accession>
    <name>A0ABR3VP01_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_1949</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="749"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1052"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1443"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1476"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1508"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="814"/>
            <end position="874"/>
        </location>
    </feature>
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        <location>
            <begin position="1757"/>
            <end position="1813"/>
        </location>
    </feature>
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        <location>
            <begin position="1688"/>
            <end position="1729"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1843362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1815" mass="200736" checksum="8C322F5CCCBDD913" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPA4</accession>
    <name>A0ABR3VPA4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843280.1"/>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
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            <end position="228"/>
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    </feature>
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        <location>
            <begin position="499"/>
            <end position="661"/>
        </location>
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            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="192"/>
            <end position="213"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="566"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="596"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="661" mass="70870" checksum="A7FBAA82461C0984" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPC6</accession>
    <name>A0ABR3VPC6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="236" mass="25932" checksum="A3D5657E1E6E17A6" modified="2025-10-08" version="1">MASLKRTGKVVCIGRNYAFSSDHIAELNSARPKQPFFFQKPTSSILLPGDGPVLRPKGVDLHYEVELALILGKRVRDLNPQDEQAALDAIDSYALSIDMTARNVQNEAKKKGLPWDISKGFDTFLPLSGPISKWAIPDPHNIELYLTVNGKVQQQDSTQLMLFRIPRILGDISKVMTLEPGDIVLTGTPKGVGPVVPGDVMRAGIRVNGEEVEEAKLEVNVEESTSSYEYSETSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPD8</accession>
    <name>A0ABR3VPD8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="152" mass="16307" checksum="BC26BFDD0FF20AF8" modified="2025-10-08" version="1">MRTDRLNDGVAPFAPDCVPKDPPGVSAAGSLGSSNEEPLNRSIGVGESSTNLASPFPSNKSWDIGPGQAVYDLNETSWRDVPWPTSPRQRNHTNSNRTGMSPSSLDRLGLLALLGCGSGILLCSIALISPCRALLPMTKQLEETLRWPPFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPY0</accession>
    <name>A0ABR3VPY0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="595"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="743" mass="80954" checksum="DC3E03C8C8E2BE2F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPZ5</accession>
    <name>A0ABR3VPZ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="699"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="763"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="114576" checksum="5A4776FAA864551F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ82</accession>
    <name>A0ABR3VQ82_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cellobiose dehydrogenase-like cytochrome domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="1">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="214" mass="23877" checksum="438800A6666490F4" modified="2025-10-08" version="1">MVLLEKLARVAAFLGLAKRQFEPDSSVYEDPETGLTFASSSTNRDVIVRVAIPDQIPDDKIYDTVLQVVAPNDIGWFGWAWGGHMTYNPLAIFWPNGTNNIVLSSRIAFGYFSPPEYPDATYTILSTGTHRNETHWQVTAKCSGCSRWGDEWIGYTELDPDYQTIMAYAWSNYPVDAPEDASTSFAIHQSLGHPIYDLAVAKNADFEAKVEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQC6</accession>
    <name>A0ABR3VQC6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="60" mass="6069" checksum="1A58F158A653FAF4" modified="2025-10-08" version="1">MDDAAAERIRRARGEKDGFSKRAADAARRNGQYQGGSSQGGSSSSKSSSSNSGGGQSCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQD0</accession>
    <name>A0ABR3VQD0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30850" checksum="DA6315D0567C4584" modified="2025-10-08" version="1">MTGKQLNEEQRALLARCFQVKKLTNAEIAFILNVSITTIQRRRIEYEKTGVLKPHRDVSKNAEKLKPHHLEVDLFSQKLVEWHKDHPDALLYDMQLFLRVHCGVNLSTSTISRQFRKAIGVTSRLSGTKARIMSRRRREAEGRSLADEIHQGAQATAAGVSSGSVSANGSRSSSAGVSGSSGNGGVQTVVGQQQGQEQQQQQQQRVLPPIPQPVAAREGGQAHHQGYGQQTAAHQSYRMEYFARPPSEPAHQGDRQQQTCRLASDQQEYVYTTTGNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQF1</accession>
    <name>A0ABR3VQF1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_96</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF2">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="586" mass="64858" checksum="002D0044C8C215A3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQN6</accession>
    <name>A0ABR3VQN6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3849</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1844193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="514" mass="55033" checksum="D93F398A4A03FD60" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQR9</accession>
    <name>A0ABR3VQR9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydantoin racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26347" checksum="A925D874A28EA6DD" modified="2025-10-08" version="1">MTHTLEQSIRGMELSSSTEVHSYTAPQLSPSSINDGEDIEASARVVMEDLNRTQILKQYDAVLVACFSAHPLVDWLAQQDGEFDRLTVTGIFEASILTALSLIRLGKKWGIVTTGKYWEEHLSDGTNRFLGSGGDRPNNQWFAGVETTRLNASDFHGGVDSEVVRQALRTATARLLAHENVECVIMGCAGMTGLERIIRSTAAELCGPERAADLFVVDGVRAGIGLLEQMVRNKRAFRGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR07</accession>
    <name>A0ABR3VR07_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3848</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1844192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="255" mass="28660" checksum="8F5A0010978FA4B4" modified="2025-10-08" version="1">MRDAKVPLAYRDSCADLLIPLNRCRFETYYLPWKCEVSQQPPTLLPTPTCHDHFDRETDVMDQTSVMNGGAAEWMKQREPTELTDDLRTDRASQLRKVPVPRVQEARGQDERAQGGQGRGAEQLRETSMLVVYIWLRGTNARRLRIHDVGYPGCCRFARTKSNLHGPSQVVDEGTSKTSLNTHNTTNDAATHGLAQAGRDVMVRRVCIWSISGSSAVLPGNKTLCLVPHLPSHRFGSPAPTLPLARHMHERSYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR22</accession>
    <name>A0ABR3VR22_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047049736" evidence="3">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1844281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="195" mass="19251" checksum="3F97FAE49FDB3697" modified="2025-10-08" version="1">MRAATFFFAAGLALVSAQTTTSNQAATTVDAAAAAQSSALDELVKCVEACPADDVNCQAKCIAVPSPNEAQVNATTNCVAACPQGDGSPADTEKYSECVSKCIGDHYYTPTLGTPSPTGAAGSGNNNNGNGNNNNNGDNNSDNNGDGNGDGNSENKDSDNKDNGSGNSGENAASAMGVAGGMMGLVGFVAAVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR26</accession>
    <name>A0ABR3VR26_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1844112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="749" mass="80693" checksum="213404404ADE3C75" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR30</accession>
    <name>A0ABR3VR30_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13894" checksum="00589F707F728402" modified="2025-10-08" version="1">MRPYGVATTLISLDSEFGPQLFKCDPAGYYIGYKGTAAGPKQQEAINHLEKKLKNKDCAPGDWKEVVELAITTLSTVLSMDFKKTEIEIGIVGGPRPDGKEGTYPGFRKLTEDEIDERLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRJ2</accession>
    <name>A0ABR3VRJ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="724"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1844053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="960" mass="102421" checksum="565810DA4ABC2DD8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRU5</accession>
    <name>A0ABR3VRU5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_66</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="3">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="64"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33519" checksum="6018C2440BB53A76" modified="2025-10-08" version="1">MIGAGGSLGCYRDRVVGFLHDVHFEPVIHLTEKVEVKTNEEEEEQIFKMRAKLFKYVADTREWKERGTGDVRLLKHRTTGKMIVERKIKGFPMKEWTVEIYILDQDGKEKPARCFTKAVYHLHPSFANPTQTFMEPPFRCTNEGWGEFEMVIDLFTTEKGGKQTILHDLNFQAPQYEVVHTVSFKNPSQALQAILRETGPLPSDEERKLKKGADGKKKKSWDVDKIADGLVKLGEDDLLHVIQLVHDHKDDNTYIQNNMDQGEFSVDLYTLPDPLLKMLWDFLIKQGVISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRV9</accession>
    <name>A0ABR3VRV9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_81</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="467"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="623"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1844402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="688" mass="76592" checksum="7621257107BFBBDE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1T0</accession>
    <name>A0ABR3V1T0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000547">
        <property type="protein sequence ID" value="KAL1835748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046421177" evidence="2">
        <location>
            <begin position="28"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="275" mass="28472" checksum="45AA4A7380E6837C" modified="2025-10-08" version="1">MTNRNTRRPSSRWAWWQVLTLATAASAISLSNIQPIEDGASVTLGCTLAYSTDITSCRISDFQRPGVCSAVCVRGLTRAMNAIQAACADADVSPTSLLGRVLAGRVVAVLCPGTFSTTITTTIRSPTPTERPSGDTSTRALTTSTFRNPTSGPLTFTTVRSATTSSSSAEETGIDDGDGDSSTTTARSIVTSQSDTPIPSPTAPSTTPTPSDQTLIPPTDTPSPDANDDEDSGNSSGGGSPFDIVRTSDAPRLPIAQWTAALGLGLLLLWCEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1Y1</accession>
    <name>A0ABR3V1Y1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000589">
        <property type="protein sequence ID" value="KAL1835615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="332" mass="35831" checksum="0DC78C94BEE73248" modified="2025-10-08" version="1">MSRDLDRSLDDILAERRQENKRAPPRNGDRRRDRSDHPRDGVRKSFRDDAPRNIDSEWVHDKFEDHGSRYRRSPDVPSDVRGTKIRVDNLHYELTQDDLEGLFSRIGPLVSLDIKYDRAGRSEGTAFVTYESHHDAKQAIAEFDGANAAGQPIRLTLLPSGPSGGGRQTAVSSRPLAERITVPGQQQGGRSRSLSPGRRAARDSDEDAARRGVDRYRPRGGRGAGGGDGRLSRSRSPPPARGDRRRGDGGRRPGGRREGGGGSRGGRGEKGTARPKKTQEELDAEMEDYFAGLGGGATPANGGAAAAAAAAAAAPQQQQQQGGGDEDVDMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V267</accession>
    <name>A0ABR3V267_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000522">
        <property type="protein sequence ID" value="KAL1835859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="223"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="350" mass="38895" checksum="2A2CFEE038AE9195" modified="2025-10-08" version="1">MDGPNNVDVNFGEFINFEESLNGDGVQEAGIAPQPASVTSPQLEQQTKLGPFPGSGSQGEFNLLGDSQSDFGLFSGSESHLALDPFLSPQSEHYAELGFEFDLELELQLNQEPVQEPFEEPYQEPEPDPVHGPDHCPDQDTDKDLDQEQDQDPDGDSEPDSEPEPDPEPLPGSRARRTRLSRTETAMSAQPGPSTRPGTNSTAKPVPSTRKSGPARQSRSSKSSKKDRLLERNWASAKRYREKKKQWLEDTQSRLTDLEEEIERKNEEILMLEEESHRLQMELMRHIACGGARIPALLEELRLRRLSVSTSTSNRMFSSLQLPPRPAPTWASPPSDWEPGSGATMPSGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2S7</accession>
    <name>A0ABR3V2S7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylglycohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000515">
        <property type="protein sequence ID" value="KAL1835892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF28">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="50258" checksum="35C0DCAA7E1B20C5" modified="2025-10-08" version="1">MPTPAQYLLNLTLQDRITGSLIGSALGDTIGLYTEFLSAAKAAEVYPSRHFTLLGPDGRPTPFHLDFHRAPKELGHWTDDTDHALLILLAFLHGADTRTSASTSPASSSTPCPASPQPTTPSSFPSSRFGGGQPPLPTQLDLAERLRVWTRQGFPPLQTMPLGLGRLVGRVVSSTSFTTDPEGRAREAWERTGRNAAPNGSLMRTHTLGLISVLRGGGLEGGVGFGGAGGVGGDGNVDVDENEDEKDDGKVEEKENTGTRGATGVVEITPAEREVFTCAARLSRVTHVDPRCVLACVIGMALVRGVVRGEVRSETDIDSVITRCLAWFRAEGKVESDGDVDEAELWRHVKPEDEDGLEALRLDEPAAIGYVYKTLGAGVVALRMAMRKEAVEGRGFLVRTRVFEELITDLVMRGGDADTNACFAGALLGGYLGYGTLPDHWKHGLKHEGWLLSKAEALCQMCMGDENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2W1</accession>
    <name>A0ABR3V2W1_HUMIN</name>
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        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000469">
        <property type="protein sequence ID" value="KAL1836077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="227"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="912" mass="100839" checksum="8CC6E692C0DD0151" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V450</accession>
    <name>A0ABR3V450_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4924</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000396">
        <property type="protein sequence ID" value="KAL1836563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="350"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="699" mass="77826" checksum="995173A3A405FD32" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V488</accession>
    <name>A0ABR3V488_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TCP-1-eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000393">
        <property type="protein sequence ID" value="KAL1836587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42069" checksum="7EF37C810594F052" modified="2025-10-08" version="1">MSFGGQTPTIIVLKEGTDTSQGKGQILSNINACLAVQATIKSTLGPYGGDLLMVDENGKQTITNDGATVMKLLDIVHPAARILVDIARSQDAEVGDGTTSVVVLAGEILKEIKEHVEAGVSSQIIIKGLRRACSMAINKIKEIQVSTTEANRRDTLHKLAATAMTSKLIKRNTEFFTKMVVDAVLSLDQDDLNEKLIGIKKIPGGSLTDSLFVNGVAFKKTFSYAGFEQQPKAFTKPKVLCLNVELELKAEKDNAEVRVEQVSEYQAIRVVQATGAVVQSTCSDIRPEHLGTCGRFEERQIGGERYNFFEDCPEAKTCTLVLRGGAEQFIAEVERSLHDAIMIVKRAIRNKTIVAGGGATEMEISAYLHRFADQDVRNKQQAVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4L6</accession>
    <name>A0ABR3V4L6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000376">
        <property type="protein sequence ID" value="KAL1836704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="69092" checksum="544D6A8C330E6B35" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4M2</accession>
    <name>A0ABR3V4M2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000423">
        <property type="protein sequence ID" value="KAL1836356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="929"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117196" checksum="9270A53EB2E7951A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4V1</accession>
    <name>A0ABR3V4V1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1836486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="63"/>
        </location>
    </feature>
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            <begin position="120"/>
            <end position="183"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="183" mass="19841" checksum="3B1CFB9FFB84877D" modified="2025-10-08" version="1">MEPHSKEKDMRQADLSEYQSKRIQLSFTDANRTPFCQSSPTKSPPQKATRSSSSPPSPRRCPWPPSLCATSTLAGTCWIGVDGTQWDQGWRIADGATGDFVKEAPSRQKDGRRTHISFFPHAACSSPHPSGHHHYGTLPEADTQTPGPPSSSASRAGWARARRPSGAPAPRDTSTSACHVRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V560</accession>
    <name>A0ABR3V560_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000352">
        <property type="protein sequence ID" value="KAL1836899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045439044" evidence="2">
        <location>
            <begin position="25"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="825" mass="83146" checksum="98C1FDDD8FB01B1D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5W9</accession>
    <name>A0ABR3V5W9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000324">
        <property type="protein sequence ID" value="KAL1837149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="69424" checksum="0F32311A84D8A9B2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Y1</accession>
    <name>A0ABR3V5Y1_HUMIN</name>
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        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4422</name>
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    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000343">
        <property type="protein sequence ID" value="KAL1836972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="182"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="765" mass="83166" checksum="8C204FEBF80A14CD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V649</accession>
    <name>A0ABR3V649_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="13">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4107</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="JAZGSY010000316">
        <property type="protein sequence ID" value="KAL1837225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 13" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="101"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1837225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="355" mass="38921" checksum="0809BA5C09A6A6BE" modified="2025-10-08" version="1">MSLLVASRSAFRAAAPLKRLQFQARHYATEQPSADPKKNNTALYGAGALAAAGAAYYFLGGSSGAAKKAEEKVKDAAAAAAKQAPATPSSEVKKALLGGDQGWISLKLEDVEIVNHNTKRFRFRLPEDDMVSGLHIASAILTKFQPIGGDKPVIRPYTPISDEDARGYLDLLVKRYPDGPMSIHLHEMVPGQRLDVKGPLPKYPWSPNKHEHIALIAGGTGITPMYQLIRAIFKNPDDKTKVTLVFGNVSEEDILLKNELAHLENTFPRRFRAFYVLDKAPASWTAGQQGYITKELLKTVLPEPKEGNDKIKVFVCGPPGMMELISGNKKSPKDQGELKGLLKELGYTPEQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6A6</accession>
    <name>A0ABR3V6A6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000342">
        <property type="protein sequence ID" value="KAL1836981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="140" mass="13840" checksum="80D2EC65C466F127" modified="2025-10-08" version="1">MDEDKAKAEKTAAARKKVFEQMRKAKAKKAGGASKKGDASTAAAAPATEDAAPQSPATAEAAATAAASGDAPEVQEPEKKKEEEATGEEPAPAADSTTTGIADATPPSLAQQSKARSASFRQGAGPLSPTTPGAGSGFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6M7</accession>
    <name>A0ABR3V6M7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000301">
        <property type="protein sequence ID" value="KAL1837366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF18">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="144"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="284" mass="31833" checksum="30F3BB8055DBB0A2" modified="2025-10-08" version="1">MVTPKKEEGGGGGMVMNTVSWRCWRDLGKVVEVWDAREAGLEDVEGVDLRTRVLPLRGLCEIMVKDLAKFEEEGLTYYDFDKFGWHDANFVMHPEHFYIAAKITPDGLYRITYGEKPGLSDEEYLARLPGIFKQILPGAPSPGEYRVVDFSPYRMHNRCAPRFRVGRVLLAADAAHLCNPWGGLGITGGLVDVGGLCECFAGMWDGRADESILDVYSEKRMEKWRTCVDAVSRANLGRMAMMEKDGDQGTQAESKVSDGAAVRAKLLAGMEMRYDFTQHYRDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6W8</accession>
    <name>A0ABR3V6W8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000290">
        <property type="protein sequence ID" value="KAL1837485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="2018"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1349"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1711"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1828"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1927"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2117"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2209"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1371"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1716"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1841"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1929"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1945"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2120"/>
            <end position="2134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2283" mass="244457" checksum="5F32DFA4D05B8CF7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7E4</accession>
    <name>A0ABR3V7E4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000273">
        <property type="protein sequence ID" value="KAL1837679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045634536" description="Hydrophobin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="17748" checksum="F5BEB9D6CE555CCF" modified="2025-10-08" version="1">MQFRNIVTVLALAMTATALPATTTDNQAGAEIVARTGGGNSNNNNNNNPHQSCSVNQFSVCCNQLKKTLNLGIPILDNLLCTVTGVVGGLAGTCNGGKAYCCNGGNGNVFKVRQDPSTEQKGIRRHVANLGLPSGRPRQHQRSQLRRHPLSEPRSFEPAWRVGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7E9</accession>
    <name>A0ABR3V7E9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_3945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000300">
        <property type="protein sequence ID" value="KAL1837386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="10"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1837386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="379" mass="40112" checksum="F519CFEC070B0CDC" modified="2025-10-08" version="1">MSSNLSFVLAKPNEVRFEERPRPKLQHPHDVLVAVNYTGICGSDVHYWQHGAIGHFVVKDPMVLGHESAGTVVEVGSQVTALKPGDRIALEPGYPCRRCSACLSGHYNLCPDMVFAATPPYDGTLTGFWTAPFDFCYKLPDNVSLQEGALIEPLAVAVHIVKQARVQPGQSVVVMGAGPVGLLCAAVARSFGATKVVSVDIVQAKLDFAKSYAATHTYLSQRVSAEENAKKLIAAADLGAGADVVIDASGAEPSIQTSLHVVKMGGTYVQGGMGKADINFPIMALCLKEVTARGSFRYGSGDYKLAIELVAAGKVNVKPLINGVVPFTEAESAFKKVKEGEVIKILIAGPNEKVEKTLDTSVDEAKLKTAQAAGKTGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Q0</accession>
    <name>A0ABR3V7Q0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000263">
        <property type="protein sequence ID" value="KAL1837784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="391" mass="44834" checksum="F25E02C7ED74A56D" modified="2025-10-08" version="1">MGPFCAWREVPGHAGYQVDESVMLHEDAWLRARAYVLWDQKRMEDEFPLGFGEPTEHPLEYTDEDYDEMIASFESASQLWRKGWVWFWIKDNESLARMRHGGDGDGVLREQGDDEEDKEQDDQEDQDSQEDPKDREDERSAISAGPSPPPLPNCRVVRKTHRESGRISPPRHLLLFLLIFQGRAGALINTTVLVLGEGLVIIQGLFEGFFVDECRVDIFDATLINYGYTDLVAPQRILFVDAPNAVRMLGKPTQRAEYQPWSFKQIIELIVFLPLNLVPYVGTPIFIMITGSRLGKLSHHRWFKLRGLNRKEVKNELRLRRWEYLWFGTVAMILELIPVLSLFFLLTSTAGSAMWVAKLEERARTRVGQPIASAHGTHGEDDGPVYHDDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8F9</accession>
    <name>A0ABR3V8F9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000245">
        <property type="protein sequence ID" value="KAL1837997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="60"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="206" mass="23088" checksum="145E8030B0ED3579" modified="2025-10-08" version="1">MAKTQNELGQPSYWDKHYSHSDGVSPVHEWLKSYSDLEAFFDRNLFTAPGVATSDNPMILHLGSGDSHIPLEFASRGYTRQLCADFSPAVVKMMSDRHASVPGIEWRLMDVRDMKSISDASVDVAFDKSTLDVMIHGSPWSPPQDVKGNTVLKDNGRFLCLTFRQPHFMKPLLNPEGLWDLDMQVLGDSGAFNYYGYLLRKASKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8H7</accession>
    <name>A0ABR3V8H7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000242">
        <property type="protein sequence ID" value="KAL1838041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="144" mass="16156" checksum="551EACE278CFAD5A" modified="2025-10-08" version="1">MLIRPAGGVKAGREASTSSTTRPPLSPSQPTRGAHVYKHAFEELMPGVRVPENVGVSCCSQLAVSHEAIRSWPKDDYVRWRKWLLKTPMSDDLSGRVFKYMWHIIFGKEVLLYPSAPQCYCDLYGLCNLKCGMRRCEGRVAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8K4</accession>
    <name>A0ABR3V8K4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000235">
        <property type="protein sequence ID" value="KAL1838148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="166" mass="17409" checksum="447F28BABB0AE1F6" modified="2025-10-08" version="1">MQWQTAEVLLVVVEGGGRIGPTRIRSREGGTERAHLEAEAGLAPVPPLGVVPIEKGQYLMLWWRGLNHPAVPLIESLAWPGHCSLPSRGLDLAVALVVEGGDLVPNGVASAQPDPLGDGPVLLLGLGQLLLGLESLEALLGGEQVVSNCSLSWRPSRPRIPHTGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8Y9</accession>
    <name>A0ABR3V8Y9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000228">
        <property type="protein sequence ID" value="KAL1838243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="339" mass="38393" checksum="8DE71BE3C5FCF941" modified="2025-10-08" version="1">MRHEQSIALQASEPPNSVSGLTTRSTSSQTWSRLTRVPDTTTSASTTTSNNQQYYEPGYEPYDEQYDEDYYDEQDDGGYDEQYDYQYGQQFGSTTLGPTFHIIEYSTINIFVNTGPSNARALPQPVHDTLENTDHCSRRRNRRRRRRRGNALRAPAQQLPGPRPIQSETSPQQQQQQEPPQQPQRQDQQHQQHQRQQLGEPKFKQEESEKQGPKIKQEEEEDVEEVRRWFGPGLLPGAFGPGPLPVSTAGDYYGGFNDSEDEAERRPGHRVSIASPWGVVGNFNGSPVLIDPAAHALPVSRPGRRRNIKTAWASDRRDVRRAINHKAAEEGAANSEWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V914</accession>
    <name>A0ABR3V914_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2868</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000228">
        <property type="protein sequence ID" value="KAL1838234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF61">
        <property type="entry name" value="HIGH AFFINITY GLUCOSE TRANSPORTER RGT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="575" mass="62405" checksum="9A1AAE5CB495CC46" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V930</accession>
    <name>A0ABR3V930_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000224">
        <property type="protein sequence ID" value="KAL1838287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="262"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="459" mass="49010" checksum="CF836B4E6D8E9FDF" modified="2025-10-08" version="1">MAPKQKAPCYVLGVGMTKFIKPRGKVDYTELGYEAGIKAMLDAQITYDDVEQGIACYCYGDSTCGQRVFYQFGMTQIPIYNVNNNCSTGSTGLHMARNMISAGAADCVLVVGFEKMNPGSLASVWNDRENPIGTTYVMMAQTRGLTKAPGAAQMFGNAGREYGAKPEDFAEIARINHAHSVNNPYSQFQDVYTLEQIMQSPKIHEPLTKLQCCPTSDGGAAAVLVSQAFLDARPHLKSQAVLIAGQGMATDSPALFSKSAIDLVGWDMSKRAARVAMEEAGVTPADFSVCELHDCFSANEMCLLDALGLAEPGKAHELVRSGGITYGPNSKVVVNPSGGLISKGHPLGATGIAQCAELVWHLRGWANNRAVPHTKWALQHNLGLGGAAVVTVYRRADGAEAPVVDSATVGKQNGLGYNPAVEARGFTAEQAKKVRSKDKTHDFAMTQTLPLMKAAQARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9N5</accession>
    <name>A0ABR3V9N5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="16">CPR</shortName>
            <shortName evidence="16">P450R</shortName>
            <ecNumber evidence="16 17">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cprA</name>
        <name evidence="20" type="ORF">VTJ49DRAFT_2855</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="16">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="16">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Endoplasmic reticulum membrane</location>
            <topology evidence="16">Single-pass membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion outer membrane</location>
            <topology evidence="16">Single-pass membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Single-pass membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="16 17"/>
    <dbReference type="EMBL" id="JAZGSY010000226">
        <property type="protein sequence ID" value="KAL1838262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 16" id="KW-0274">FAD</keyword>
    <keyword evidence="2 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 16" id="KW-0288">FMN</keyword>
    <keyword evidence="1 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="10 16 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="14 16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="65"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="273"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="448"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="466"/>
            <end position="468"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="483"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="611"/>
            <end position="612"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="617"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL1838262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="692" mass="77092" checksum="55379842CC3D45B2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9S4</accession>
    <name>A0ABR3V9S4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000205">
        <property type="protein sequence ID" value="KAL1838590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="283" mass="30466" checksum="8F1500FFB4429CEA" modified="2025-10-08" version="1">MSPPLPPPPPRHPPRRRTPGHNLPRPPQKSAPEAQKKKAKKAEKPETSRAAAAAPSSTTTAAVTATAGAASKPPPRGPVMSAAVPATSSSKPLDKMEYHERVVHSMLTDPLGFDDCVYDSRKPKPAHVARSFARFRNRQTQPPPPLEMRGAIGPAEDDDEDDTKNGKGKGKGKDANGTPKKKRPQSQSLAKEAQLRAHKRKLEDKVEGLKSKGKAVAEEREEKAFMSGGNKESRGPSTPVANGGKLGEKKRLTNGNGKQSVQGQRKGGYKPQGMLARKFKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9W0</accession>
    <name>A0ABR3V9W0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000233">
        <property type="protein sequence ID" value="KAL1838171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="140" mass="15461" checksum="22EA96A9C027BB0E" modified="2025-10-08" version="1">MTKPRYFPHYSSFSEQLSNQSRYSQTVRIGNRIECSGQGGWDDSGAIPTSLAAEFDQAFANVDACLRSAGAKGWSDVYRINLYTTHLSEAVEVWEPCVLKWLGPEHRPLLTAVGVAALALPGMRVEIEVVALTEDDQGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAJ3</accession>
    <name>A0ABR3VAJ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trafficking protein particle complex subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000190">
        <property type="protein sequence ID" value="KAL1838844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28052" checksum="DDBE15110005E08E" modified="2025-10-08" version="1">MSFEPVMPPYNASDPSARFVSASCLDFLLIELVPMAHRITRQLEGRAKEEEERWLASLSSSSNPTTSSSTSDPAASGGGANGNENGEDASTSASAGRITAAGGAGEVDGEIEIEAGTLIDEEEEREAVFWRLEAIGYRVGQGLAERFSRDRPRFNDTLDIIKFLCKDLWTLVFRKQVDNLKTNHRGVYVLTDNAFRPFARMSAEVSSQAVLRAQPFLWFPCGIIRGALAAMGITATVQAETSELPSAVFQIKTVPVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAK9</accession>
    <name>A0ABR3VAK9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000189">
        <property type="protein sequence ID" value="KAL1838859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02867">
        <property type="entry name" value="PseudoU_synth_TruB_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA pseudouridylate synthase B C-terminal" evidence="8">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="443" mass="49275" checksum="695042547B9D858F" modified="2025-10-08" version="1">MAADNVFEGVFAINKPFGMSSYQVIRDCQSVFNPSTLFKPLLDRDRAQREKESKYQKRRRSKVKQELNVKMGHGGTLDPLATGVLILGIGRGTKSLHDFLGCTKTYETVVLFGASTDTYDRTGRIIKKGRYEDVTREAVESALASFRGRIRQVPPIYSALKMEGKPLYEYAREGKPIPREIETREVDVLELELVEWYEPGTHNHRWPTEEAEQAEKNLVDSVWRVAKRQQAAAEASEEGTPGRLTPAQQQEEERALAEYNTKKREADERVDNLVTDSGAGEEEPPATKRRKTNTEGGAEPMMSGALGQLPPVQRPRGKGSNLVPPPPSPDTPPPWEGKGPPAAKLRMTVSSGFYVRNLCHDLGEKLGCGGLMAELARTRQNQFALGGPRCMEYDDLFKGEEVWGPQVRRMLELWNGSKAEAVQDGPAKERSPAKGKSPVKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAT5</accession>
    <name>A0ABR3VAT5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000185">
        <property type="protein sequence ID" value="KAL1838934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="14654" checksum="0221DBF62E2C5F2C" modified="2025-10-08" version="1">MAKISRGAPGGKLKMSLGLPVGAIMNCADNSGARNLYIISVKGIGARLNRLPAGGVGDMVMATVKKGKPELRKKVHPAVIVRQAKPWKRFDGVFLYFEDNAGVIVNPKGEMKGSAITGPVGKEAAELWPRIASNSGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB06</accession>
    <name>A0ABR3VB06_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000181">
        <property type="protein sequence ID" value="KAL1838985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="104" mass="11496" checksum="9A9E1D30BF87CD22" modified="2025-10-08" version="1">MDNPSADRDYKAELDKLATGTKTPPKNEKNEDTSIANKVSQYVPAVGKLLGGSQMDEPESKESPSTFKPPGPPHRTQNDPQIEDFIRDQHRSEKMVAANEVTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBB7</accession>
    <name>A0ABR3VBB7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000180">
        <property type="protein sequence ID" value="KAL1839002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="434" mass="47141" checksum="79F44A20E54C5E97" modified="2025-10-08" version="1">MTARRRPAPQKHLQVPTNNNTKDRGGSSDKTYTVPAPSPRVINAAPSLEKAEMYGIDDNRPVFSRAMALAGRMFIETIPQWLAVGAMLSLIFGGCCSNVFALESIVKVEPASGTLLTFVQFAFVAATGLPSQFDPKRPPFFLKPNRVPLRRWLVNIVLFFSINVLNNHAFSYDISVPVHIILRSGGSITTMLAGSLYGKKYSRIQVVAVLLLTVGVITAAWSDSQTKVATTSDNKSVGPASFGTGLAILFVAQVLSAIMGLYTEETYRIYGPLWKENLFYSHLLSLPLFLPFLPSMSRQFMKLAHSAPLALSVPRLLLDEDHSDIASAVQSAVDRIRIPSQLFYLALNVLTQYACIRGVNLLAAASSALTVTIVLNIRKLVSLLLSIWLFGNRLATGTLIGAVIVFFAGGLYSLDGKRKTGPPVRRATPAAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBI5</accession>
    <name>A0ABR3VBI5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF2428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000176">
        <property type="protein sequence ID" value="KAL1839076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="5">
        <location>
            <begin position="245"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="4">
        <location>
            <begin position="669"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="6">
        <location>
            <begin position="912"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1609" mass="177610" checksum="876ED34ABAE6047F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBI6</accession>
    <name>A0ABR3VBI6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000176">
        <property type="protein sequence ID" value="KAL1839083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF7">
        <property type="entry name" value="DUF1749-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="319" mass="35207" checksum="11FE5D1EC4F22C3D" modified="2025-10-08" version="1">MSLPQSYPVLVHNYLPSANADPTRPLQTYEHLPSLNPEQKPENALVFLCGLGDGPHSIPYVRRLAEHLAVTAPGWSVFEARLGSNFSAFGYGSLAEDVREVRRTGCQDCLEYAKVLVAERRRGTGRGGVEGAATEEEEEEEEGGEDEEVVRVDGYVLQGPVSDREAIAMAEDAREVAAAIREAEEMRRQGRGSEVMPVNVLPKGWRGSPVSAYRWWSLAAVGGDDDYFSSDLPESRLAEIWGNLDVPVLIMPSGKEEWVPASLNVPAMVERWKSFAKPGIVSELSGLIPGANHRVDNDEGREWLIDRVARFLHEVEGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBJ4</accession>
    <name>A0ABR3VBJ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_1731</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000169">
        <property type="protein sequence ID" value="KAL1839213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
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            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="368"/>
            <end position="390"/>
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            <begin position="133"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="456"/>
            <end position="692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1839213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="707" mass="78441" checksum="7B3F6B001E08A733" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBP5</accession>
    <name>A0ABR3VBP5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II beta 2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000205">
        <property type="protein sequence ID" value="KAL1838593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="47419" checksum="68EFFF8BCDA15E75" modified="2025-10-08" version="1">MSSIGGMAPVVVRALRAHLRLATDMLRSKVASATRQINSELQPIVVRTGNAKQPVHPAAWLRQQKRAASKRWFSSANLGSTVRRFISSAGHSGPQHGARFDRSKLPSSTISRAVSQLTGRAPFASTLRPNLTGGTLGRTAGGYAIPGCGRIGGARHFSHTPTAPAQVIQNVSQAMRAFWLSGQRARFDGFGPNGEKRYRAVSAKQEAARVAMAKTMMVHRSAPGAFVDFKISPTVTALSPLGAAIPFTTAEVAATPSLHTEGFLDVLSVDFARALKDLAAVMTDLKRLSTLGDLPVSMIGNNILRVRFPGMDADTVESLCRDVGVKRGVVGQDPDFDANPAVDMALRFPFAPDAGPCDEETLTSPGGSLRSHGSAPSSDIEEMFIVDEFDDNPWILSSGSEPEGYGSMSPSALGSPGAAQSEGFEGLEGIYRFLEECDRARAHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBQ0</accession>
    <name>A0ABR3VBQ0_HUMIN</name>
    <protein>
        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000168">
        <property type="protein sequence ID" value="KAL1839240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="217"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="920"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="978" mass="108009" checksum="780D9932A78AA6D9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBX9</accession>
    <name>A0ABR3VBX9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000162">
        <property type="protein sequence ID" value="KAL1839348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="26200" checksum="04C8F70497AE4738" modified="2025-10-08" version="1">MFAKPRIRKTAPPPPPKKRKTVHAIEEISFDPKARNEYLTGFRKRKQERIKRAQEIAEKKAREARIELRKQIREQRKQEVEEHVQAINKILREAEYAGTEHNDQDNTDEEWGGLSDEEVPEAPIDVEEEYIDEDKYTTVTVEAVSVDRDGLHKPELEKSSEDEDSEDGDGKEKQEQDKSEESKRPKHPPKKKKKKFRYENKFERALEQRKQKARKRKLRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCF1</accession>
    <name>A0ABR3VCF1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000161">
        <property type="protein sequence ID" value="KAL1839374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="204" mass="23178" checksum="0DC6BD201202EAAB" modified="2025-10-08" version="1">MFLDHIAFVLRDIGKGSSDERLLQDHLGRWRDSLLRLLTELPELAKSLRRFFTFPYEGRPIPQPLSAGLMDLEAEIRAMEERCERAQQSLRSDLSLVESKRGILEAESVSRLTKLAFVFIPLTFAAGLFSMQVQELTDSPPPLSTFIGAAAVVMAVSYGLRIAQHSVWLGNQRRKLEDRIRRDMLSPQPPSFWHSSCFLKPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD45</accession>
    <name>A0ABR3VD45_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000164">
        <property type="protein sequence ID" value="KAL1839321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="611" mass="70298" checksum="52B7C6C794FF9C0B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD71</accession>
    <name>A0ABR3VD71_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000144">
        <property type="protein sequence ID" value="KAL1839706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="281"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="39934" checksum="FE88A7527CDCF3C3" modified="2025-10-08" version="1">MTTIPSSTPGWSKVQIPRPLQRLFDLFPLRAYEPNHLPERSQQLTSSSLPTLYIFTTEEDARLGLPSFNPTCLRWQTLLRLTGLEFRVLPSTNHASPTGALPFLLPARSNSSSSSSSSTSPPSSSSPSQPPPPPPTPIPASKLLPYAQSHANPTKSSHPATSGDRLFPTRARAYVALVSSHLRSAWLCALYLDPSRSDLLDALYLRPASSSAAVRAALRRQLRKAAGEQILDSAPAAGALQSGSGSGSGTGEVGNNKSRGWGWSWQEDGTAINPRAVYASAREAMAALASLLAESKTEWFFDADAPSEFDAAVFSYTHLMIQYMSDGEEEAGALGKMVRRAGEGELARHREMLWRFAWPEGNGEVKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD96</accession>
    <name>A0ABR3VD96_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sphingolipid long chain base-responsive protein LSP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF4">
        <property type="entry name" value="PRIMARY COMPONENT OF EISOSOMES (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53851" checksum="4B8264033FA20537" modified="2025-10-08" version="1">MCFGTPRRAYYNEPVLAPRPRPWYGPRPPPPPPGCRPPPRYYRPRPCPPPPPPGHHHHHHGPPPPMGRPPMGGPPPHRHPHGPPPGHRPGPGFGPRRRNRALSLRSSNRSSNRSSNTTTSNGTTTTMSGGLAPGIGNTPNPTTTQPQPRHNHGHHGFTLPSLRTSTLPPLSKRLQRLIKSANSLISAHESAARERLSVATQLSEWGEQASKGLFQTDSPKDTTPSLRPGSTITTTTTTDGIVNGSSTDTAVSDLTDKLAVLLSEIGEQDAAYATRLEASRSVLKAIRDTERSVQPARDGRRKVAEELARLRAREPRSPRVVTLEQELVRAEAEGLVAEAQLGNVTRQKLREAYTLEFAATIERAEKQAILARHGLRLLQLLDDTPAVPGEARPPYLHAAQARQVLDDAEDDMKEWRLDLGFLEVRNGYEDEGRREVKREEHEEVEQEEVQQEKQEKENQREERKQYDGEVKAEEGQRLAGDIEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDK2</accession>
    <name>A0ABR3VDK2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 17.8 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000138">
        <property type="protein sequence ID" value="KAL1839841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20433" checksum="09F033CACE254E7E" modified="2025-10-08" version="1">MSALRQTAAQVARRARTVRPKSLRTTRSYASEHGHDHHHHEHNVEESLGVAFYGTLGVLFGSIFVYKISRPGPNGELSTLHKYWQKVSDYGSQWETRAQVMAAALEQASHDKHLLLNADRSKHRELTYPEVFTHGSPHNIPAGHYVKLDKVIAHYQKQHLEEEARKAKKLAAEASQQSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDQ7</accession>
    <name>A0ABR3VDQ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000161">
        <property type="protein sequence ID" value="KAL1839373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="300" mass="32704" checksum="E45536544654E7AE" modified="2025-10-08" version="1">MVAVQTPADAVRALGMRAYAGPSLFQPHHARQAIRDAYDKKIPPLIGYYAGLSSIDITRFLAPMGYDMVWIDWEHTSCNVETMTTMVHETIFMSEGRTIPFVRVPGHDHAAIGYALDAGASIVIPQLETVEQAKHVVSAAKFGRKFGGTRSVPPFRLVPGLTDTPADPSLGDVWRNVNDQAAIMVQIETLEGINNLDAILTEVPDIDVVWLGGLDCRVSMGFPANLGQGAEPEWLAAVDKFNKTLKKHRKPRAGFCFGGGAELAKMAHDNVLLVHSADVMKLYEMGPQLMSARQAVALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDS1</accession>
    <name>A0ABR3VDS1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000134">
        <property type="protein sequence ID" value="KAL1839952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
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                <person name="Grimwood J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Drula E."/>
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                <person name="Nguyen T.T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1989"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2035"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2125"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2169"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2192"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2242"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="2275"/>
            <end position="2302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="2302" mass="252288" checksum="C6C3A0672663F701" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEE3</accession>
    <name>A0ABR3VEE3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000129">
        <property type="protein sequence ID" value="KAL1840058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF2">
        <property type="entry name" value="GDSL-LIKE LIPASE_ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046067473" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="228"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="396" mass="42128" checksum="65C71D90EEEF71BE" modified="2025-10-08" version="1">MFSLNRWAAFAVSALALLGSQTTVAAPASDNGIVAPRQDDGWHWVASWTSMPQQVEPNNMPPGQFNSGGGVFRDATLRQTVYLTLRATRLRVQISNTFGGSDLPITAASIALPQGGRAGVAGIDTSTLKPLTFNNGSPSITIPRGQVAYSDPVDFPVNARTNVAISLYFRNGQSGSIITGHPGSRTTSHMQQGNRVNDATLFGGNTKHWYFLSAVEAWSPPTTSAFVILGDSITDGRGSTDDNNDRWPDLLVARMQQVGNITNIGVCNQAAGGNAILSGGLGPTLLTRYRRDALQVAGVKYVMIFEGVNDIGNSSPDSGTQNSMVTRLQQAYQQIVRDCKAAGLKTIGATITPFGGSGQSYSNPAREQTRVRVNEWILNSGTFDATVDFAGRGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEQ0</accession>
    <name>A0ABR3VEQ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="442" mass="48130" checksum="38E4843C3E282FBC" modified="2025-10-08" version="1">MSTDLHLPHQLPGHDKTLRAACHCGSVDFTVTVPTSALPLPVHLCHCSICRYLHGTLSCFHADLPKGIQPEFVPPSSLASSRTGYIHAQAVSERLFCTTCGCHIGDRSLKPDPETGMPHWCVASSIFTTHDEDTFQIRSHWYSSPATEPNLATWLPAINSRPIHFWNPPAAAASRDAAPQGEGEEEEPSHRRQPGPDNDENADKALLAQCLCTGVTFSILPPTKEEAADPFLSQFLQPDPAAKESESTSSPSRSLKRSAGICLCRDCRLVSGAHAVAWMFVPLGRLRPGGGTGGGVEEGREEQEQQQRGDDDKFGLSQFGRTLRTYHSSPGVTRGFCGVCGATVFYAMDSPERIPPPLPTSRADAGADAEEEKKRVLVDVAVGILRDPSGSVAAENWLVWQTRCEGMETGRAFDRGFAEGLERGLGEWGEKRYGRRVEFEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VES6</accession>
    <name>A0ABR3VES6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000116">
        <property type="protein sequence ID" value="KAL1840360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="548"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="199"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="429"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="699"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1058"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1262" mass="144885" checksum="697AC48146DCCC88" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VET0</accession>
    <name>A0ABR3VET0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000126">
        <property type="protein sequence ID" value="KAL1840130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39627" checksum="168D96F209980A8E" modified="2025-10-08" version="1">MAAETSPAPASPEPQTQPAAEMPIEVDSVSFPDRDSVIDDDVSALTQSITSSILDFPVENGRRYHAFRAGVYCLPNDDLEQDRLDLSHLLMTKTIGNKLFLAPIDQAKMQRVLDIGTGTGIWSMAMGDEYPHAEACKPNDDYILGNDLSPIQPPWVPPNVKFEVDDVEDPWVYRTPFDFIFCRYMMASIKDWPALVKNAYDNLNPGGWVEFQDYDIMYYSEDGSLKPESATHQWISELIDTSNKIGRDPQPGRSLEKWVREAGFEKVEHHKFRMPIGGWPKDPGLKQIGTYNLAQLLSGLEAFSLRLYCGVLGWSKEELMVLLAKVRKELKDPKLHAQFDFHVVYGQKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF17</accession>
    <name>A0ABR3VF17_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="905" mass="98555" checksum="6E711CEBB512553D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF78</accession>
    <name>A0ABR3VF78_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000115">
        <property type="protein sequence ID" value="KAL1840394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="54"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="242" mass="26884" checksum="493F3B394E21FCDE" modified="2025-10-08" version="1">MEKLLTHLRAKRRRIPLEGLAPQRSLPRLKSWPGLEDLTIGTATPVSLRGMKALEVGCGAGLPVLNLFLQEKMDAVGVDLSSVQLGLAEENTKPSPPASSCDLNRLRQCSDGYSPRGKLELVESDMMELRYPPESFDAIVGLYSLVHLPREEQTVFLHRAARWLKREGLLMVNFAREEVEGEVRTGWLGQEEGWVYFSGWGEKTVKVLEEAGLEVLEREVADGVDGVSGLTYVWVIARKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF99</accession>
    <name>A0ABR3VF99_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="114"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="542" mass="59016" checksum="446FEA8A1FCDE892" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFU8</accession>
    <name>A0ABR3VFU8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">VTJ49DRAFT_257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="97" mass="10453" checksum="0F6E44329E5A2F40" modified="2025-10-08" version="1">MSLNAYTDKRVCIITTDGRNLVGTLAAHDYTTNLVLKNTVERVIRSPDDGEPSAEVPLGLYMIRGDNVALVGLVDEALDASINWTEVKGAPIGTTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFX5</accession>
    <name>A0ABR3VFX5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arsenite methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000114">
        <property type="protein sequence ID" value="KAL1840407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF8">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="63"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="369" mass="38365" checksum="796290B0660105BE" modified="2025-10-08" version="1">MDTTEIYEKVREHYSSASRMTSVKYGETVAKSFGYSADELANIPQDANLGLSCGNPLAIASLKEGETVIDLGSGAGFDVFLAAKKVGTSGRAIGVDMNDDMLARAERIKSSQPASYGPTSHISFVKSNITSIDLPSETADCIISNCVINLVPAPEKPAVFREMHRLLKPGGRVAVSDILAKKPFTEELKRDVALYVGCVAGASEVREYETWLREAGFKDIMIVDTNADLNVYLETNEDGERKGMGLCCAPGLDPAESESAAAAGGCCGPAKTESTSDGGCCAPKKTESAQASGGCCAPKSTETPQAGSGGCCGPAKTAVAEQSAGGCCVPKSDEPKATVCGVPAPSSSLLGKTNLNEWAGSYKIFAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGA8</accession>
    <name>A0ABR3VGA8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="4">
        <location>
            <begin position="249"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="374" mass="41279" checksum="19C304F7CBF9D30F" modified="2025-10-08" version="1">MVSFWPWGRDDSSPASFEKALSGLAAKITSTQARLDQTRTRSRRMKALATLYLVIAYLVYGIVEMLVVGWKNMGPFEWTAMAGGPVLIVLVRTIITTFYEYRIERLNARLKEYQDERAKTIQKLKDATKYDSTLELLEKYGGETRNKKTPKPTEEGGAPEGDKVAQTKGKHQGLPDRINMPPPPTANIQRPPALGPNTSQSRPLSRHGAPVQPHTDMAESAEFAPNAFDGKPPQNYLQYPAAVPVEPRWYDRILDMLLGEDETAAKNRIALICARCRLVNGQAPPGTKSLSEIGMWKCMACGAQNGEMDEGKRIVAEVLGARAVATKDDITDDTASRNSGELVEVDKESEGPEGKQDVDSVTEGPKKRRGKAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGK6</accession>
    <name>A0ABR3VGK6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000093">
        <property type="protein sequence ID" value="KAL1840950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="70" mass="7473" checksum="050A69E4DFC805ED" modified="2025-10-08" version="1">MCSKILIYCHNSSCTNEVGVLYEECSDAREGRCLFGQFELGLMELEKGSAAKLAGMGSIWGGSDEGFGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGL6</accession>
    <name>A0ABR3VGL6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000093">
        <property type="protein sequence ID" value="KAL1840934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="490"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="727"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="921"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="937"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113472" checksum="6C6D42C31AA8A965" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGS7</accession>
    <name>A0ABR3VGS7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000118">
        <property type="protein sequence ID" value="KAL1840316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF74">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="322"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="603"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="898"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1041" mass="114620" checksum="DFEE4A767708F531" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH05</accession>
    <name>A0ABR3VH05_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000085">
        <property type="protein sequence ID" value="KAL1841149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="606" mass="67044" checksum="407AD55C6B9332A3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH78</accession>
    <name>A0ABR3VH78_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress response protein rds1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046499978" description="Stress response protein rds1p" evidence="2">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="43308" checksum="8A7828B41682FFF9" modified="2025-10-08" version="1">MHCLSNFIPLLTCLATTASAMSPVGKPRQHPAKMPSHHPGEAQKLADPNYGPIPGHSSLYSTYLGVERPFPGNITDPILPTEDGQPDPDDHVWQNLLSAEWIIFEFYQFGVEKFSQEDFVKAGFPATTLDCLKEIRNNEAGHLRIFQNQISNASVKPGACKYIFPFQDPTSYLAYLTVVEISSMAFLSGLVQDVVSDRSKGAMAAISQTEARHEVWALTELWRSGPFSGPSDTSFPYANQILYSTRGRIVPGSCPPENPEYPTPRQLLPGLGATPDTQSLSPGATITLTFPDPDGIVPEFDPDTQYYGVFFHGLRNISVPIDTEGFPDKPVMVTIPEEFEHTGIIVALVADEPGAPTKESVVAGPAVMLEQPAKVGVALLHGEAQESRQESLLRFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHG6</accession>
    <name>A0ABR3VHG6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="288" mass="33112" checksum="9F1B50A33BFE9362" modified="2025-10-08" version="1">MYSIMPQTPPRFSFGPSAEVHHRHRPAFSSPLSSSPIRGSSPSPPPPEQQMNGQEQQQKCNQPFTQWSSNTFNTRPQHTQSSPIFPSRTGLISPTTTDQNGGSCYGSNPKFRFASRSSRPNPLLRRREDAQEGRRRLFLQNVRQRQEDKRWEMRGGEDELLKLEWQRLSYERQKALEAEFAQFDADLAAREEEELRRMQQQQQLTFPPNPNDRDLDAMMADVIAQQEEAEMQALLEALEGGGGAPGQAQPQQQQFSDDDDYDDVFMDLIRQQEEQSRTMAYSQDVEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIB0</accession>
    <name>A0ABR3VIB0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046421190" description="Tyrosinase copper-binding domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="411" mass="43947" checksum="21D9951C71078DCD" modified="2025-10-08" version="1">MRLNLPFLALAALQAASAMALDPPAEVPNDPAEALQELEALGEAAYLEVTAELEEPASKRLRKRTGGSCTLSKLRVRREWGSLTSSQKTAYINAVKCLQSKSALTPSELAPGAKTRFDDFVATHINQTLHIHYTGNFHAWHRYYVWIYETALRTECGYTGAQPYWDWAKTAITGLANSPIFDGSATSFSGDGAFIPDKPNLELGGGLGLPPLVLPPGSGGGCVTSGPFVDMVVNLGPVSLDLPGGLVGVNPDGPLAWNPRCLKRDLTDAINQRFANATSVLKNIVLPSTAEVFNTMMEGVPGSGEMGVHGGGHYAMGGDPGRDVFVSPGDPVFYLHHAAVDRVWWLWQLLSPSTRMQGASSVAGTRTMMNMPPSDPTTIEDYVDLGFAGGVPTKIKDLLKTTGGPLCYVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIC7</accession>
    <name>A0ABR3VIC7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38839" checksum="BD4A548E5ACF9125" modified="2025-10-08" version="1">MGWFDGWFGSSNNNNDSDPLRRLDPKLREFLERESPVKYNLSTPPPPPPPPPSSQQQQQQQQQHQHQHADQQTPAVPPQSLFPDGRYAHLWKTYRPLSAIEAETKSDSEKLSDVISAFKERKGMIGRAALENCAEEQSEWAACMKSGTWRARATMCRDEVHKFERCYAAQTRLLKALGYLSVAGRSPEVDEEIQMRADELYQRMLQREKEIETAKQEGREPPPMKGLFDDIGDVRLPEQGKSAAAAAPGTGATEPLPEPGPTTLAEWKKKLDRLPPEEREAEEKALRAEFRSKVELARQVQGLWEEQARERKKRREEGNERFFDRFADMAARWRGTKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJC3</accession>
    <name>A0ABR3VJC3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="814"/>
        </location>
    </feature>
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        <location>
            <begin position="866"/>
            <end position="990"/>
        </location>
    </feature>
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            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
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        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
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        <location>
            <begin position="898"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
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            <begin position="941"/>
            <end position="978"/>
        </location>
    </feature>
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        <location>
            <begin position="979"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1109" mass="120376" checksum="9649188ABF47F56F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJD3</accession>
    <name>A0ABR3VJD3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6566</name>
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    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
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        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="13"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1841813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="444" mass="51254" checksum="E3D5FEC02D9DC786" modified="2025-10-08" version="1">MSPRMNGLGIMPEDTRICVVMVGLPARGKSYIAQKAQRYLRWLSVPARTFNVGNYRRENAPQPSADFFDVNNAEGERKRRAAAQAAVDDMLKWFREEQGVVAIFDATNSTKERRKWVLDQVSKEGIEVIFVESKCDDEELIMANIRDVKTSSPDYVGQDPEKAALDFRERIRNYEKVYRSINEDGDEDHLTYLKIMNVGKKVFINRIQDYLQSRVVYFLMNLHIRPRSVWLSRHGESLLNLEGRIGGDADLSSRGEEYARKLPELVRQSVGSDRPLTVWTSTLKRTIQTARHLPKHYNQLQWKALDELDAGVCDGMTYQEIADQYPEDFQARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSEDILIISHQAVIRCIYAYFMQKTQEESPWVPVPLHTLIKLTPMAYGTEIERYSANIKAVSTWRGKGSTAKHEDPAPEGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJK4</accession>
    <name>A0ABR3VJK4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division control protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31278" checksum="BDBB49708ADFAB53" modified="2025-10-08" version="1">METLLSLAFDNLSSFDGSKIKKGLKQVEGLLAQICLSGPSPSSPRKQQQQSPDAARDHPARKGLADLSGDPAFREFFKLQEGFEWNIAQRLLTTLDWLVVRGGDGQYDLLIVHALDLIQGVLLLHPPSKALLSRSVYMNLLLDLLEPINCPAIQSATVITLVVALNGHPRNTRVFEQLDGLLAVTSLFKSRDTGRDVKFRLTEFLYFYLTPETPSSPRQRSASKVSKVLGGGGGDGEVQNGGGEGGGDGLTLSVEEKKQLVDRYLPGVVDELLKDLDTYKPFCGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJM0</accession>
    <name>A0ABR3VJM0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="96" mass="11062" checksum="57EA48BC36B8B9A1" modified="2025-10-08" version="1">MADREPYVHPTRDPNFYGDDNHQANQALGDSAEQPRERKAGDRADYETSDKMIYYICGNCGLRCGFQANDVLRCRDCGGMTMYKPRMRMLLQYQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJT8</accession>
    <name>A0ABR3VJT8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="394"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="589" mass="64483" checksum="255C992960AEFA53" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK47</accession>
    <name>A0ABR3VK47_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="615" mass="68654" checksum="1ACDDADF51CB73C9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKQ9</accession>
    <name>A0ABR3VKQ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="110" mass="12977" checksum="C8A02B55A41799D8" modified="2025-10-08" version="1">MFGPFRITNVLNGGLLWKIPWRLSPTQKARQRKRLRAVDQVIEVVSNALAKKGETLKSLDRWKAEMPTEAEMLPRDKYTMFDRKAKRYRKGIHKLPKWTRVSQRVNPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKU0</accession>
    <name>A0ABR3VKU0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000047">
        <property type="protein sequence ID" value="KAL1842308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="72" mass="8111" checksum="55E0063030787C91" modified="2025-10-08" version="1">MTALFNFTSLLLVILLLICTCTYLHQLFPAILDRNKTGITGIFWKCARIGERLSPYMSLCCGIMAISIFFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKY5</accession>
    <name>A0ABR3VKY5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000044">
        <property type="protein sequence ID" value="KAL1842392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="672"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="740"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="795" mass="88197" checksum="0C34E567DD52B331" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLL3</accession>
    <name>A0ABR3VLL3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4773</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="115"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="301"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="771" mass="87649" checksum="2EB5D1513F288662" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLT4</accession>
    <name>A0ABR3VLT4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase</fullName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VTJ49DRAFT_4011</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="475"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="788"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="18">
        <location>
            <begin position="1242"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="59"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="149"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL1842844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1452" mass="163676" checksum="87D2DAAD510C23D2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLW4</accession>
    <name>A0ABR3VLW4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="375" mass="38785" checksum="7DD7008B97D23A44" modified="2025-10-08" version="1">MSSPMSAKMASLPALKRQHLLAEFAGLKQACPRGVYVAPTPGDPSLWTGVLFVQKGPYAPAVLRFHISFPDAYPARPPLVTFSTDLFHPLITPLTTYMYSPDAGSDGAEASAADDERLLPPGGFSLRHGFPGWFGGRGRGRGRGTPAAASGGGGSGGAQGGEESSTGTTMQTTPPRPVATATGEAGVGSTPGSDPAHSQSDVPGYARTRTTGAGAGGGEVSTYEVLRYIRSVFDDEDVLDSVPLEAAGNPGAWHAWRTHRRQQQAVGTAGKGQGPQPVSGQQLQEGAGVEPTSVPAGANVHVNANANALPRRPGEWNWEGVWEERVKRGIAASLSDGVLYGNAGGTDDVITFLSMDEAEVESAKSNLLRTLGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM31</accession>
    <name>A0ABR3VM31_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_4568</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1842657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="135" mass="14550" checksum="10C3A745CA88455C" modified="2025-10-08" version="1">MASLTYQDVAEHNTKKDLYVVIHDKIYDITKFVDEHPGGEEVLLDVAGQDATEAFEDVGHSDEARETLEQLKIGTLKRNPGDPKPKTPAPGAVAPQANTSTAGFGTALYAILLVGGLLGYFGYQYLQQQQAAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM77</accession>
    <name>A0ABR3VM77_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="8">
        <location>
            <begin position="94"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="9">
        <location>
            <begin position="283"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="10">
        <location>
            <begin position="625"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="809" mass="89224" checksum="EACF4E478317C4FC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMB9</accession>
    <name>A0ABR3VMB9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="437" mass="50308" checksum="C76B199DC92DE463" modified="2025-10-08" version="1">MASDHQQGTGEYRQYLPDLSIPRFTTMQKQDAHEYAAAFKESGNPPWLHSLYLHWRKLFQEPFKGITNDGRVRPDLFHLRDEGIPIDTIVSAANTLLSHLTPSQITTLTYHIDSPEWRSWSNPEFLLSDKGLRLDELDPPTRSAALAILEATLSPEGYQKALAAMRINGFLGELVKAPRVMNEFSYNLVLFGTPSTTAPWGFSFYGHHLCLNAFLYRTQLVLSPWFTGAEPNLIDSGPYAGTRILHEEEKLGLRLMQSLSSEDDASVRARVQIYPKLRDPNMPRGRWNRDDQRHLCGAYRDNRVVPYEGLPVSDMTDPQREMVRAILREYLLYLPQRSRELHMEEIEKWFGETYFCWIGGYGDQDAFYYRIQSPVVLVEFDHHSGVFLTNEEPKRFHIHTLLRTPNGGDYGMALRGLIPGGVEQEFVWEGEEDLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMI3</accession>
    <name>A0ABR3VMI3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc toxin complex TcA C-terminal TcB-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040840">
        <property type="entry name" value="TcA_TcB_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18276">
        <property type="entry name" value="TcA_TcB_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc toxin complex TcA C-terminal TcB-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="384" mass="42858" checksum="B7E8A6F51865CD08" modified="2025-10-08" version="1">MEAWLRTKYTNQQLYGWMEKELRSLYYQAYTLAMSAARRAERALAFEQGRNVSVLRPAGYWDASRDGLLAADHLWLDLKRLELAHAENRNHDYEITKTVSLRQIDPLALLRLRFTGSTTFTPGEHLFDMDFPGHHMRRLRSVAVSIPAVIGLHGGVNATLTLLNSKYRVDTTAMTGDEYRSADRSAFRYDRVPISSVAISTGSHDAGAFELSFGGPRYAAFEGAGAVSEWKLELPTEVPRFDYETIGDVVLHLQYTALEGGACLRKAANEAVRSIARATEMEGAGPEGFWGFWDLKNDFARDAAKKDNTAAQRPISLKLGDLKARLPFFSRRQQSLKVKSVALLSKNVKLVDALSIDGVTSDAGDTHVKQPDMKLPILLVLDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMK0</accession>
    <name>A0ABR3VMK0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Four helix bundle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12809" checksum="BF6DA4D047686E36" modified="2025-10-08" version="1">MPDISSDLRRSVALQVNFRDIVETAIGLHQYREFRSRQPLVEAAFEVIESGIRCKFQLERNEVSVRVAKEELKTCRSSLTNLMSQLSVFLDGRDKEEVLEKRRKIWIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMS0</accession>
    <name>A0ABR3VMS0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="10">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="122" mass="13688" checksum="41736DDBD7421CBF" modified="2025-10-08" version="1">MGIWDVITELVEAAAPWSTADAEAPAEVPEETKAEEPEEEAEEDEEEEEEEEEPVDPKETLEEECKNSKECAPAKHHFDECVERVTNAQENGGTKEDCVEEFFHLAHCASQCAAPKLWSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNK9</accession>
    <name>A0ABR3VNK9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="413" mass="47090" checksum="E43EC0A963D67F69" modified="2025-10-08" version="1">MRILAPSPKEGGWEITEEPFSVEALADLPKQCYVFLDVADYQHTDGRRERILSHFGVPAYVANRTCFEINGFFGSKASYGDGGDLSGYSTWFRTLVKMVRKVPEDAHDDAPEYATGKKDYKWFEMTFFSRWCRPTGSQGEGATAQVLCVDTPFDFIDELKKLLEKDGQLQLDLRDPFALHTSLVDQVVVYADISVWRVRDPVRRLEKTRLRLGAIFNPIHEMNRHAIHTTEVLEASIDTLTALQERRAAVHERLGDRLGEEYRERARDYGEFQLSLVKNLKLRSQSNQERLKDEIDLAFNNLSRQDNDVQKSIAVLTMVFLPATFISAVFSTTFYNFGEDGTWEVSPKQWIYWATTIPATILSVFIWQMWVSHSDSISRVAGNLFKWPPTLGQGKREKKKGAATSPAGKVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNL9</accession>
    <name>A0ABR3VNL9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="10">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lipoate synthase</fullName>
            <shortName evidence="10">LS</shortName>
            <shortName evidence="10">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="146"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1843268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="423" mass="46349" checksum="E7CA52D35EE89CB9" modified="2025-10-08" version="1">MASTMPLQRIQAPLRRSLARAAVLSCRTYATVPSGPASDPAQQQQPTTESPSTPKPRPTYFKNTTLGSLSDFLPTGSEAYTPRTAVVGPEGRKRTITRLPEWLKTPLPAPGANPNYARIKSDLRGLGLHTVCEEARCPNIGECWGGSNRAAATATIMLMGDTCTRGCRFCSVKTSRRPPPLDPHEPENTAEALARWGLGYVVLTSVDRDDLADGGARHFAETIRRIKAKKPTMLVEALTGDFAGDLECVKIVAESGLDVYAHNVETVEALTPYVRDRRATFRQSLKVLEHVKAVRGKEGIITKTSLMLGLGEQEEEIWDALKELRKADVDVVTFGQYMQPTKRHLKVERYVTPDEFELWRQRALDMGFLYCASGPLVRSSYKAGEAFIENVLRKRAGEKAAAMTTQGLDPAISATAETSGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPM0</accession>
    <name>A0ABR3VPM0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52264" checksum="CBCC56065A37877B" modified="2025-10-08" version="1">MPSKGVDVYTYIAVPGCAIEVSVPKHHVKLTDLHRFHKVGMEVDAMAISSFFDKRGRFTFKVFHNGALVTEQWIDVNALTGNASGGTMEVISQTPAIFYGDKLVVCYGLYEAGPGHGILPNRHQCYVTVTPIYENYIRDLAPPGSPLENKPFARFVLPSPHDVGMNSMSSTEAVLRRVGGAVVAELIHDHRYITRLADALSGRAIALLAPNIVFSLAITQKDTLETLLRLGARYFEFRPARLHKAVIPTGALTPAERHYFQHSAIPGMPYDAFLRGVVDFLRSHPAEIIVVQLRWDGVPTDVCTPPTDEEKRRHLDDALRGSDIVAGNLDDMRRKTVAQLRKDKKRLIMLDSVDSLSTYGDDTYATLNGDSILASLPGVLKKENQRGKAFVNIQCQATASNIPKAVAFSVLQAGSTTSCLLATKGVCDHKILPWVRDNVLNTIELDQLVVLMNDWLEGATVDVAAKLSKQRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPR4</accession>
    <name>A0ABR3VPR4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF16">
        <property type="entry name" value="CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="268" mass="28896" checksum="EC11EBAB4407FA89" modified="2025-10-08" version="1">MSTPSITTLAARARSFKGLHVPGTPLRLANVYDATSARIVGSLPGCRALASASHAVAEASGTTDEQLTLEQNLTHLAPVAAVAHELGLPLTIDLQDGYGERLEEAVRLAITELGAVGINLEDSRHEDGSMMDEDEAVERIRRTLRVAAELGVPDFVVNARSDTFLMKAGSLDESVRRGRKYLEAGATTVYVIWPFDQEMLEEDVKRAIGGLDGKVNILPRKASTGQRRDLTPADVARLGAARISVGPHLYRVMREALTEAANEVFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ30</accession>
    <name>A0ABR3VQ30_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="52065" checksum="3E4AB3B376AFA590" modified="2025-10-08" version="1">MAANSPPSPTSSQLPPLPGSPTYSYASTANPSLSQYNLPLPPPPRPAHAVLTKADLENSQAAYSDLLASAKSYRLALSNLATAASSFGAALEACARLKEARADALGPPQGGSLSNSFTAHQATCTADTLLTVAGLQHLVANHQHILSETVYRAFEVPLLHELDKWRAAVEDEEEGYARAVAEQSKEIRRLEKEGLKLHRQRRRDVARFRSHLVELTAKLDGLTVRHAEHARTLLRESQDTSARIVDASCSLARAEVDIFESLARKGWTGGGLDEVLEKGVDVFAADEADVGGKGGAGIVGGDGPGGVGGSAGGEGAKLFSILPPKSILADASSSGGGGLTRSDSLLGDDADRYQSIDSAVTATGATADPVKDRDAESIFSFDGHGHNRSNSRARNVRPFSPQPLPIRLNPEDLLGGLEHGAGDVVETSSDAGRGGRTDDEEEDDDEQHPWRNEGLRRRGTPSDDESSKGTIRLGAGLGDDHSRQESWGEASGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQD7</accession>
    <name>A0ABR3VQD7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4974</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="145"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="299"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="380"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="751"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1844122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1172" mass="133787" checksum="69AC71FEBE5F9551" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQE3</accession>
    <name>A0ABR3VQE3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_4992</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1844140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="99" mass="11665" checksum="260C91CF7006B00E" modified="2025-10-08" version="1">MSTRQAALSLYRRSLKLALDWSVHRHLWRGQALYIRSLFEQNRNVTDPRLQRALLKETEKLLEKWKHPDPYIHPTAPGGSKYERNLPVPNLDPPPPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQJ5</accession>
    <name>A0ABR3VQJ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_7501</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="373"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="589"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="770"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="843"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1843791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="871" mass="96950" checksum="898EFB77B2A6CB12" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQM0</accession>
    <name>A0ABR3VQM0_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="709"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="456"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="75099" checksum="688B2D1141FCA9AA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQR3</accession>
    <name>A0ABR3VQR3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1844242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="190" mass="21133" checksum="FC74A668D5B9D095" modified="2025-10-08" version="1">MLCRDLWLTAPASREACPIPFSWPGPFGQTIRACSAPKSPLMYAIECGWALDQIKVLVQAGCSVDVRRRTNSCFLLSRGGGLHHHCTPKVCKDRTECLKPTFFWRPKQTLDGSMCQTALHVAISKRKPEILEFLLGECGANRGSLQWPGEEPIPGNCVVPLGEVLQNHGVNISRWFSLNGPRITILQQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQV8</accession>
    <name>A0ABR3VQV8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="626"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1844190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="871" mass="99850" checksum="9BBDBCA5A792D45A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR35</accession>
    <name>A0ABR3VR35_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="101"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="429" mass="47751" checksum="FA35C0D9D6DDA99B" modified="2025-10-08" version="1">MHAAKLRPWSRRSPSVKLSAQINGPYLFLLYYQVQTRENDTLPRLPSALSSVILLLSVTAPLSARAERVLADDDSCECYLINNDQGTYYTHHRFFDFRNLSEYAGVPPVIRDAASSARAEATSDYFLSDEWKTFWMLNTWNNSASRRADATVAMVNSPNNVYIEASTEATPTSHTWLTLRTQRLAGFQTAAEFETISDRFKYLSIRMRARTVGAPGAITALFTYRTADTLAEVQEADLEIRTSDPRDVLHYTNQPSYTEAGDVIPGATINTTMPGGREWTSWATHRLDWTPGRTTWYVDGEETASSEFQAPRDESTIIVNAWSDGGIWTGNMSRFDAAYLQVQWIELVFNSTARRNGPGGDEVSKKKVRRGGERGCKVVCSIDETPLLGTPVLLWESGAARRLRDGGIVAWVPRAVVLVTVLVATGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRC4</accession>
    <name>A0ABR3VRC4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_2349</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="636"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1844292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1218" mass="137612" checksum="7A9322EA969C09E4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRQ8</accession>
    <name>A0ABR3VRQ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_21</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="151" mass="15527" checksum="F4DF2AE9EED0ADFD" modified="2025-10-08" version="1">MVGLPRLLKENEETNMAAEDRQPPTVHEGATTTTADVEDEAAATTAKSAEDRKAAAALSKLDARGDDDEAATNVDQEAVKNAMSALSSGGAGGAAAAGAAKKEVKNVKVDAGDVKLLVDELELSKPKATELLKAHDGDAVKALKAYLQPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRV0</accession>
    <name>A0ABR3VRV0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_61</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="474"/>
        </location>
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        <location>
            <begin position="490"/>
            <end position="532"/>
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    </feature>
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            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
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        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="532" mass="58756" checksum="BCB3D5FCF13A78F7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Humicola insolens</name>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
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                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Drula E."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="10 11">CBS 620.91</strain>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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            <begin position="348"/>
            <end position="362"/>
        </location>
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        <location>
            <begin position="384"/>
            <end position="400"/>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="9">Protein ORM1</fullName>
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
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                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
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                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAZGSY010000633">
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
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                <person name="Riley R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047129193" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
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            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28674" checksum="CE661A0C0041EED6" modified="2025-10-08" version="1">MKSALLLFGGLTAVGAQSTATRTSTATTPGQCDGFLPTPDDFPSCRRLTKLLAECATNPAKAEDNVACFCTQDMLNAMVHCKGEIRSCLNSYFTDTSYDNLISIWNDRCQPHLTTLYPSGSITTPTLASLTATVDLDGCKTAWSACVQRDDAVRSCMRSLLTDVTQTITGWAGRTRTVTRPAAATNKEEIMSSCLCQESHLSLASVCNERKYHGDQYYTGANANGRGYDGGLCQLDWVGDFVAVILFIVAEEHRSLGLGGFSDADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1M4</accession>
    <name>A0ABR3V1M4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000566">
        <property type="protein sequence ID" value="KAL1835684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10055" checksum="26733F483B509514" modified="2025-10-08" version="1">MDGVVAILVAILCLFFPPLAVFIMAGCGVDLLINVILTIWLWFPGCIHAAYLLIVYYDRRDKYKTGRIPLSRAPFVYSDKVQSGGTVYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1W7</accession>
    <name>A0ABR3V1W7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000539">
        <property type="protein sequence ID" value="KAL1835775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="189"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="250" mass="29029" checksum="95E49DF5E8B97636" modified="2025-10-08" version="1">MATPTNLLRLCLRPSRRLPSLRAVSAQQRLLRRPLSTTPPCRRDDADAEKEKDADEEEYERFYSNPGQFLKDFLREENISDHERRLATQMLEDWNKVPANVAKGIDSLTQEINELGAAIRRPVQARQKSFWHDEEDDPDMVTDEVGEDDFEEDDMMAVAHAKLEEHREFREYARVAVWEMPLLSKLAKPFQPPAEDQVLRFRYTTYMGEFHPADRKVVVEFCPEDLPGLTEAQVLKLKKLAGSRRRTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2B6</accession>
    <name>A0ABR3V2B6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000610">
        <property type="protein sequence ID" value="KAL1835546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="942" mass="98611" checksum="C7508AE6C8E4A4CE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3Q8</accession>
    <name>A0ABR3V3Q8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000483">
        <property type="protein sequence ID" value="KAL1836011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045084705" description="VanZ-like domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ-like" evidence="4">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="234" mass="25210" checksum="0BC8BE8F07C39010" modified="2025-10-08" version="1">MRIRLPFAGAFATLLLISAYLGLSPSTPDPDATPPLPFPFDDKGLHFLTFFILTVTFYWVVDTTRRRATHLSLLLCTAGLGIGSEVLQALLPNGREFDLWDIVANVVGSLAGLGLCAWYHRRMLERRRRRKYTAVPTTTGEEGAEGGEEDVELGEGVGLGGRDREDEHEEGVTTTTTTTAAAPSAAKATTLEEEVDNWDENAEDAWDEDDEGDVGVSAPAAAGKAGGEGKKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3Y6</accession>
    <name>A0ABR3V3Y6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000405">
        <property type="protein sequence ID" value="KAL1836482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="768"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="772"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1007" mass="107800" checksum="FA90EE6FED622700" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V426</accession>
    <name>A0ABR3V426_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000399">
        <property type="protein sequence ID" value="KAL1836528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="STI1" evidence="4">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="154" mass="15438" checksum="5830FA225C12DC92" modified="2025-10-08" version="1">MEAYSKGIEYEGNGGSEAMKKGYETARRRVEELEADEAAAAQSTRSAGAGAGAGGGLADLAGMFGGGGGAGGSGGGMPDFASIMNNPMFASMAQNLMSNPDMMANLMNNPRLRQLADQFGRGGGMPDIGSLMSDPSIAEMARNLMGGAGRGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4P0</accession>
    <name>A0ABR3V4P0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Infection structure specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000371">
        <property type="protein sequence ID" value="KAL1836743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045359516" description="Infection structure specific protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="26703" checksum="E6A2E58AB15CAC8C" modified="2025-10-08" version="1">MRSAVVAIPVLATLMGVSNAAGALALTPLATYPPVRPAPKPYAHGGPGVNRPAFPAPTPQPGQKQDSALVLSQVPARPTATQISPEKCSEVASRITPQLTPNPTYPASLKAMADKIGGIERDTCGDLNLAARYKSVDAKELNKFTQARYQTFILPMWARVQELWAACGDEAARFPAVSTEPCYRWALELSKASNASFGVPGKGSNKVATDDKGQVGSDNKDNEQTAVEPESGAGAMSSTVAALVGTLALLGATVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Q3</accession>
    <name>A0ABR3V4Q3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000371">
        <property type="protein sequence ID" value="KAL1836738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="285"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="954" mass="107475" checksum="5F199EB0E49AEB60" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4U1</accession>
    <name>A0ABR3V4U1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000367">
        <property type="protein sequence ID" value="KAL1836779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="135" mass="14410" checksum="39A2C5A720A0B315" modified="2025-10-08" version="1">MFKSGISAFARTARPSFAAATRRAVRPTSLNLRASALSRFASTSSVGDGKIYQVIGTIVELSLPPRPKGPSLASSGKIAFRSSWLTAQLCQQQVPSSMVSSPHTRPRRCITNTNGSLRAPRFAYVVDWVADAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4X5</accession>
    <name>A0ABR3V4X5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000362">
        <property type="protein sequence ID" value="KAL1836817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1433" mass="158566" checksum="1B80A4928EA45904" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5T9</accession>
    <name>A0ABR3V5T9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000327">
        <property type="protein sequence ID" value="KAL1837119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="190" mass="21498" checksum="8C9A026743D43DA2" modified="2025-10-08" version="1">MPSSLPTWPNSAWPSRCRRHRPGPFSPLHPIIPPQSLAQQRTKTLPSPPPDHQTTQPTNPVSLSLSHPHSDLAPQARRPNRETHPLRRRLPPRRPTSPPPRLPPPRHLRQGPDLFRQLHPDPLHGRRSERFPLRLRGRLPRGPLPGLAPRERLPGGRFRRAPRRGQGGTEDACCVAVCVPRCQRDEVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Z6</accession>
    <name>A0ABR3V5Z6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000342">
        <property type="protein sequence ID" value="KAL1836987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="60"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="569"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1331"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1436"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1255"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1340"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1378"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1442"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1462"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1492"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1518"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1537" mass="167448" checksum="9EBE6533E143EB1E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V673</accession>
    <name>A0ABR3V673_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000312">
        <property type="protein sequence ID" value="KAL1837267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046617586" evidence="1">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="419" mass="43822" checksum="F33244FF14E0B59A" modified="2025-10-08" version="1">MRSPAIVSLLGGLASTALAAPEYDIPLCDTDEYGGCALPSGPLTARGLPRHAGLFRRDPEECPADNKLCTSSGVLPPELDPQTIPLVCGNTATSNSVTASYGPCPSDETTNCLLFDLSGTDLDTPKLQIKASPLTDAATFDYNDYCTSTSCAVPIDAVIENEGLPTPYVLCGPTTRLWIALQTTLDGDTCWADGAPISANKKKRSKCKPQDPTNDTPTQFSIGFTCPEENLVCCCCPPSTEEPPPPGKSCAASAWAVGFDGSPELKSLGCTDGPGYYLHLTPEEAAGSVLTSFRKLTADGEEEVLGLAQVSISTDDESGTCAQVIAGVDNEDPLNPRYTLGRLRAYIGCEDPGAGLGESCGEGSAYTTLDSACIEGMTSHFVWGCGLPTCAEGYYVVVYADVAEAAEEGATCEEYVCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V726</accession>
    <name>A0ABR3V726_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000280">
        <property type="protein sequence ID" value="KAL1837583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="197"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="786"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1157" mass="125995" checksum="46E20D57526AE40A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7B5</accession>
    <name>A0ABR3V7B5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000286">
        <property type="protein sequence ID" value="KAL1837520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="97" mass="10738" checksum="E3EA49AB16FD5176" modified="2025-10-08" version="1">MAPAAAGAKKQKKKWSKGKVKDKAQHAVILDKATSDKLYKDVQSYRLVTVATLVDRLKINGSLARQCLKDLEEKGQIKQVVGHSRMKIYTRAVSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7G9</accession>
    <name>A0ABR3V7G9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000267">
        <property type="protein sequence ID" value="KAL1837735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF101">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="282" mass="31059" checksum="488FDC5AE9B0AAD9" modified="2025-10-08" version="1">MSTPFTLAAGAAVAGLGVYAWYTRSNNTQSDMPVFSSFGFRTLRLESTELISHNTKKLRFELPDRTQPSGLSLTSSLLAVSLPQGRWIPVLRPYTPVNDLSEPGYIELMVKLYSNGKQSTHLHSLQPGDTLTFAPIPGYRWTPNQHQHLAMIAGGAGITPMYQLLRGILRNENDKTRVTLVWGVNTDDDIFLKDEFADLEARFSDRFKAVYAVSSPKEGSPHVKGYVTKELLEAAGLAPNTPGNGDLKVLVCGPPAMEKALKKRKTGVLAQLGYRPDQIHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7I7</accession>
    <name>A0ABR3V7I7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_3422</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000265">
        <property type="protein sequence ID" value="KAL1837758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046302953" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1837758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="227" mass="24303" checksum="E3972F0D300B7BC3" modified="2025-10-08" version="1">MKLSVALTVLASALAEAHYTFPSVGNTADWQVVRQTTNFQSNGPVTDVNSDQIRCYERFPGQGAPSIYNVTAGQTLSYNAKASISHPGPMAVYIAQVPAGYTAANWDGKGAVWSKIYQDQARIAGSISWPNNGARSISVTIPRCLQDGHYLLRAEHIALHSASGVGGAQFYISCAQLYVSGGTGTWNPLNKVAFPGAYSPTHPGIMINIYWPLPTSYRPPGPEPEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7U1</accession>
    <name>A0ABR3V7U1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_3380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000261">
        <property type="protein sequence ID" value="KAL1837815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="614"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1837815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="707" mass="77326" checksum="4165872C7702A024" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7X8</accession>
    <name>A0ABR3V7X8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000258">
        <property type="protein sequence ID" value="KAL1837846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="249" mass="26872" checksum="521B57F2E6FDDC15" modified="2025-10-08" version="1">MATKHHVVLPGEPIDPSLIPTHPKHPLRLGPGLRHIPPEDIVPTVAGQLITNPAKNSMWIEYNSNRYIPSQNDLVLAQILRSTSDFYLCSLSPHTAPATLPHLAFEAATKKTRPQLSPGQLVYARVSLANKHMDPELECVHPSTGKADGLGPITGPGCAFDVSLGFARRLLMARSREEGGVGVLEMLGGEEGGGLAFETAVGRNGRVWVGSESARTVVIVGRALQETDRLGLGLEGQRKLVKRLVREIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Y1</accession>
    <name>A0ABR3V7Y1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000257">
        <property type="protein sequence ID" value="KAL1837860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="109" mass="11939" checksum="9BA2339A147ABD77" modified="2025-10-08" version="1">MASNGRPIIITVEPGTSQSSSSAPSITYSMSSRGSAGSTPDTSRPPSPFEAVYRDSSSSTNFVHVKEVRDSRGGQSTMVIHHNRRSTPDTAEPRSSDYYRLHKEHNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Z9</accession>
    <name>A0ABR3V7Z9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000284">
        <property type="protein sequence ID" value="KAL1837541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF6">
        <property type="entry name" value="CYTOCHROME P450 2C30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="56171" checksum="EE7028D796116BEF" modified="2025-10-08" version="1">MASLTLVLLYLAISSLIFSVVKQVLSWRKTRRLQGRFPGPRLFPIVGRVHDVPRFSPWLKFKEWADEYGPIYYTRALHQPFIIVSGQQIAEELLVKRGDIYSGRPQLRCIINHKEGPAYVALMDRHDTWRTQRKWAHAAVTKAYRHHFYGHVETEMKRYLGLLLLDPALFLDYTREFSGRIMSRLAWDDATQGRANGDSANQTLHCMSASGPLPNTVTPLWHLPGFMNPWYKFEVRRQREQRAWWLNNYRLAKDRMLRGDLPADTWAYRYFEQLRRDGGNESLEQAEDQEVFASCMIGFLNLIGVVPVSGLLKFFLMAMAVHPEWQKKAQARLTAGVMIKKGTIILACEWAMNRVPSTYPDGDNFRPERWLEPGWPTYQEPLTRYPNFREGFGMHTFGWGRRTCLGQNIVDGEVFVFGAATLWAFNLSQKRCPRTGEPVPIDTQATNSHVILEPLPYQINIKVRSEKRGRQVLEGYNEVRTGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V810</accession>
    <name>A0ABR3V810_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000264">
        <property type="protein sequence ID" value="KAL1837775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1207" mass="135127" checksum="52B4B0813586C508" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V816</accession>
    <name>A0ABR3V816_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">carbamoyl-phosphate synthase (ammonia)</fullName>
            <ecNumber evidence="7">6.3.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_3224</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000249">
        <property type="protein sequence ID" value="KAL1837953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="219"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="756"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="15">
        <location>
            <begin position="1021"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1837953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1170" mass="128733" checksum="5E7D14A40FDEB194" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8H9</accession>
    <name>A0ABR3V8H9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">USB1</name>
        <name evidence="7" type="ORF">VTJ49DRAFT_3023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000237">
        <property type="protein sequence ID" value="KAL1838118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="404" mass="42928" checksum="2591F1F36B3022E9" modified="2025-10-08" version="1">MPLVDYSSDSNSDPDPDPNQVSSTTTSSPPPSGLPPPKKKPRTDDLPPLPAAFHDLYASTVRTAPRDDPALHQGRVRQIPHLPGHWPTHVYVEWLPPADVYALLDELLGELRTRVGRKDCRRAGLGGGGVEDEDGDVEIHSLLHSDLGAPLPLHISLSRPLSLPTEVREGFRRDLEAGLFSGGDGGGGGDGGGRIKCFELECTRAEWHRTHESARSFLVLRVRSVRFHGGGGGAGLESMGKRSPDQGHDGNNNNDNSNNDTNPPNPNPELTTLLHRCNTIATRYNQPRLYDWAESPSSSSSPSQPPTTSTPNNATPRNGVGNAFHISLAWSHSPPTPSLTAATEAVFCSQESPAAQALRRVRVPVGAVKVKIGNVVSSLELSPSSSSSGPGTGSGSAGRNLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8Q7</accession>
    <name>A0ABR3V8Q7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000291">
        <property type="protein sequence ID" value="KAL1837468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046579178" evidence="1">
        <location>
            <begin position="23"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="372" mass="39190" checksum="A21F178FC981F7C4" modified="2025-10-08" version="1">MSLRLLSVLALALATGKTLVGAAPAVNGREHVLLNPRVYDTLMGSPASVRNESSSNQGTLKIARQPGQFINATLTILTTVTVPMDATSTTSIVTTSAEADRPYGTFFAITTSANMTSTEVDQPYGTFLAITPSTNTTLVEGDCPYGTFLAMTTNTTSTEIGQPYGTFLEVDRLTTTPVPTPAAWLANATLKQRDDDDPFTWPTSGYSTSVFTWTFGSTQEMNVTVLVQTTETPSSSTADSEDVTVTVTDTHVVTATVTMKGATAPTALATSTGTSSTVLDQPYGPPMLRDIRPLPSDLGEPAPTSVPWLADEALEQRNGDSTTLLADCITTVVTTVETTITEFVVGSTGSSEVDDMVETGFVMPSFTNGLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8T3</accession>
    <name>A0ABR3V8T3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000228">
        <property type="protein sequence ID" value="KAL1838244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046342685" evidence="1">
        <location>
            <begin position="16"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="363" mass="39026" checksum="935ECC663D282342" modified="2025-10-08" version="1">MKFLSALSLIPLVAAAPAAEVSPRGLEVPNSVVPSSVRVRGISLLGSGCPAGSADVQIDATKTLIEVTFSEYIVETGPGTRAADWRKNCKLTLNLEFDEGFQFATLATDMSGFAQIPEGSRGTCTNTFDFTGATGQSYYALALPGPREGPFTLHADPDAVSWSPCGGTTAIMNMNTQCNISPTRNPALIAVSFFHALGSLTVNWGLLTFSSRNTGRSHQRQDHGQHLGPVAEVLEGARDRPMIRRSRSLDMRMMLMTCGWGCGGSLSLHQGPGMDLLSCTSFGVDQEMHVLFLLSHIFCLIQPTISQRKKQHRPPDGDPTHRVCLTTRAPSRWCCRGSRGYPGSCSAPFLGPFGIATVSYLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V967</accession>
    <name>A0ABR3V967_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2967</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000233">
        <property type="protein sequence ID" value="KAL1838165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="769"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="58"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="229"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="488"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="936"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="806"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1015" mass="114637" checksum="11C7C0ABBA694C07" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9A2</accession>
    <name>A0ABR3V9A2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000215">
        <property type="protein sequence ID" value="KAL1838418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="216"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="592"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="678" mass="72844" checksum="432CCEC3B715A9CC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9F9</accession>
    <name>A0ABR3V9F9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="13">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_2864</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="13"/>
    <dbReference type="EMBL" id="JAZGSY010000227">
        <property type="protein sequence ID" value="KAL1838255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1128"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1161"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1210"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1264"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1290"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="198"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="16">
        <location>
            <begin position="1098"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1838255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1334" mass="147005" checksum="19F73221CB690883" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9L7</accession>
    <name>A0ABR3V9L7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF2">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046106642" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="227" mass="23738" checksum="B0112047FD42E3C1" modified="2025-10-08" version="1">MFLSSALLLAAAGVANAHFGLDYPPMRANTLGKDVDPAYSQWLHPCAGVPSNLTDSPKTEWPLTGGSVKLDLRHQWTYVFINLGLGSDVSNFNYTLTNPFWNTTGNGTLCVEKLSLPADLPVEDGSPASLQVVTLDDNGNALYNCADIIFKADAKPLEGDDCKTVGVTYAPIQVSESSDDDDSQGSDDDAADDSSTPGNAGSATGVNRVALSSAVALAVVFVFGMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9U2</accession>
    <name>A0ABR3V9U2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">VTJ49DRAFT_2540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="202"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="632"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="728"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="903" mass="95936" checksum="48C21FAC4CA81568" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA68</accession>
    <name>A0ABR3VA68_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="186"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="360" mass="39068" checksum="EBEEAA20351B0923" modified="2025-10-08" version="1">MGSLSTLPTEMKALRYNKPKEFEIVKVPLPTLRDDDVLVKVKACGVCGTDLVRPPHLGHIHEGEFIAQFPLIPGHETIGVVAAMGPKVTGFQIGDRVAADNSELCGHCFYCRRGEGLLCENWRGHGINLPGGFAEYCAYPQAKVFPIRNLTDVDATLIEPASCAAHGLDKIRPRLGSSVLMFGAGPTGLMLAQLLRHNGCTQLTLAAPPGPKLELAQKLDVATAYVELPRDASAQATVLNRIRAENPYGFDIVVEATGSTRILEGAIDFCRRGGTLVVYGVYPNAARVSWPPAKIFGDELRIIGSFSEVYMFPQTIDYLESGLIKTQGIVNKTFRLEQYGEALASIRDKTAIKAAIVFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA84</accession>
    <name>A0ABR3VA84_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000203">
        <property type="protein sequence ID" value="KAL1838626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="108"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="477"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="554" mass="62278" checksum="52E4CAAD1630BF32" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAS9</accession>
    <name>A0ABR3VAS9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000191">
        <property type="protein sequence ID" value="KAL1838834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046147163" description="CBM1 domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="9">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="317" mass="32932" checksum="CD22BE717A7C38C6" modified="2025-10-08" version="1">MWPTPKVAFLLLAAHSLLVSGSPVDAEVLDAALAARQSCPEIHIFGARETTTPPGYGSAGRVVDMIKGAFPGATSEAINYPACGGQGNCGGVQYGDSARQGTSAVAQAVNSFHQRCPNTKLVLVGYSQGGQIMDNAVCGGPDSGSNISTTASPINASAHEQIKAVILMGSPRYVAGLSYNVGTCTAQGFAARNRGYVCSTNSASKIQNYCDRQDPYCCTGNDANHHQQYGTIYGQQALNFVRARLTESGGGNTTPTQPTNPTQPTQPPTQPPTNPGNGGGNCASLWGQCGGQGWNGPTCCSQGTCRAQNQWYSQCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAW5</accession>
    <name>A0ABR3VAW5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NUC153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000198">
        <property type="protein sequence ID" value="KAL1838697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="9">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="8">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="72194" checksum="01A2DAFDF01C5E16" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBA0</accession>
    <name>A0ABR3VBA0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">VTJ49DRAFT_2004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000181">
        <property type="protein sequence ID" value="KAL1838993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1838993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="487" mass="51964" checksum="85DE99FDE1BF8B89" modified="2025-10-08" version="1">MDEPMADAPGPQVKVTFTTTETDLQLPETKRQLLVPADIRRYGLSRILNSESMLDTGSIPFDFLINGSFLRTSLQDYLTANGLSLETNLTLQYVRSLIPPVYEASFEHDDWVSAVDVLSATSPAGRWSGDSFQNGQDRILSASYDGLLRIWNASGQVITTSPSGSHGGHTASIKAAKFLTNTQLASAGMDRTVRVWKYTETDAFSGELKPTLELYGHAGSVDSLEVDGSSRRLLTASADGAIGFWSTSKASAPEPDASLLPNAHTSKRRRLATSVTVAQRGPLFLMPVHTAPATAAVFDPRDRTVAYSASQDHTVRTLDLTTGSVVTTLATSHPLLSLCAIPRAGGGSPLLAAGTSARHITMLDPRANTAATSVMTLRGHGNKVVSIAASPDNDYSLVSASHDGTCRIWDLRSVRPATKDEGGMGSVSEPVYVIERESLKTEKGAKKRPVAGEGCKVFSVVWDRLGIFSGGEDKKVQVNSGRDVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBH1</accession>
    <name>A0ABR3VBH1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000177">
        <property type="protein sequence ID" value="KAL1839068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="195" mass="21476" checksum="3E2B40C182B53A81" modified="2025-10-08" version="1">MTSSIGIPIKLLNEAQVRHLSSSSSNSQNKLAGKLTHRVPPPPAGPHRHPRNHLRHDLPRQADRGRGQHERPAQGHHRDGARRPRQPPRTGLHPRQPRALLYRPRHVEVRQQPCENEKPCSRQEAGEEEEEQALANQAFCLSTGTRQCSAAATCAVGASVWREEGRLLAGRGLAGAGGRGGNWRKKGRAVCLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBX1</accession>
    <name>A0ABR3VBX1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000169">
        <property type="protein sequence ID" value="KAL1839212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1000">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="2"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="602"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="756" mass="82936" checksum="477E6C16D73FF443" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCI0</accession>
    <name>A0ABR3VCI0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000163">
        <property type="protein sequence ID" value="KAL1839335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="66"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="410" mass="45859" checksum="F395712959A291DA" modified="2025-10-08" version="1">MADSSAFAPRTMKRKNVKGLALKAPAPKPPPTADNDRFGYGNGKEDTSNQLEIGIEFNLDLKPDDLEMIKELGAGNGGTVSKVRHIPTNTVMARKIIHVEAKKELRKRIVRELQIMHGCHSDYIVTFYGAFLNENNDVVMCMEHMDVGSLDRISRVYGPVRVDVLGKIAEATLGGLTYLYAKHHIMHRDIKPSNILVNSRGQIKLCDFGVSGELTNSVANTFVGTSTYMAPERIQGFPYTVKSDVWSFGLTIMELAIGKFPFAASEHLSDAESSAPAGILDLLQQIVHEPAPRLPKSDAFPQILEDMIQKCLSKEPEHRPTPQQLYDHDLFVQAAKRTPVDLREWACSVMERDPRPAQLSPQDLRSSDSPTYGTQHTPTTSYRVDPRHHADHANLAAQVDRLYIREWDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCN0</accession>
    <name>A0ABR3VCN0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="188" mass="20534" checksum="54991F12323248C4" modified="2025-10-08" version="1">MFGFGFGFFYGSSSSSSSSCSSSSSLDSVASAAAPYGTISSPMDIALRSSSSRRGPDPECAYPSWPRRLSLGEDDSEERATSYIPDDELLFPDVFEDDASSVSSSASPVHSPVGAPVLTEAEILQLHREQLAYQREMRRLLQAEKELRRRAAEQEHQQRRRQGGAKRRTASGPSKRTRAKLPAIAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCW0</accession>
    <name>A0ABR3VCW0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase</fullName>
            <shortName evidence="5">UDG</shortName>
            <ecNumber evidence="5">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UNG1</name>
        <name evidence="9" type="ORF">VTJ49DRAFT_1420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000152">
        <property type="protein sequence ID" value="KAL1839518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="8">
        <location>
            <begin position="119"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="416" mass="46020" checksum="E6C9F90E8BFE0253" modified="2025-10-08" version="1">MSNLKRKAAAEAGAEPKKAKQGTLTSFFSGPKPAASSTSSASEPPAIKFDKAKWVASLTAEQRQLLQLEIDTLHESWLALLKDELVTKEFLDLKRFLDRETKAERKWFPPKEDVYSWSRYTPFHSVRVVILGQDPYHNHNQAHGLAFSVRPPTPAPPSLKNMYTALQNDYPSFVVPPNRGGLLTPWAERGVLMLNTCLTVRAHEANSHSNRGWERFTQRVIDLVAQRRTRGVVFMAWGTPAGKRVQKVDAKRHLVLKSVHPSPLSASRGFFTCGHFRKANDWLEERYGSEGRVDWSLVPGRSIFDASPPPEAEEAVSGKGTGAKGEVVKKVEAVVKQALSASFHVMEDEEEEMMRAAAEAEAKLEKEKEGNNSKTTATTSTTTTNTATTAKTEVVETKKEGVQVEGDENAAPDVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD97</accession>
    <name>A0ABR3VD97_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_1202</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000142">
        <property type="protein sequence ID" value="KAL1839736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="322"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="526"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="740"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="672"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="802"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1839736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="820" mass="89994" checksum="81A478E38F3E914D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDA6</accession>
    <name>A0ABR3VDA6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="204" mass="22226" checksum="F2E0C4F3E8F771A5" modified="2025-10-08" version="1">MVRQKDRYLLVNIIYNDVPPSQAKDSVPDLLLYNQPTSGELRPQHLLKGIRSEVAALFGDCGSGAVERSLQGMKYLSPATSTFILRVSRAHYRLVWAALAFMNRVPVRDGRPCVFRVVRVSGTIRKIEEEAVRRAKLLVRAARSEMVAAATDGPSSSAAASSALSTLLRVDRDQPRRTAAVQQSDLGEDSPMAVDVDSGDSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDF8</accession>
    <name>A0ABR3VDF8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="351" mass="39671" checksum="9ED1C4C8BA343661" modified="2025-10-08" version="1">MSDVADETTTNTYDGFSHMAMVLTPPSSHDDMGALKIVDPDGDLILRSERSGSIKVCSAALRRASPVFKAMLFGPWKEAKPATGTWVVHIDDSEWPNALDIILPVIHGVPFDPPAVNAQQLSEVLIFADLYDMRQLLRPWITQCLVQHCKRGVEWKIPIYNQLRLLPLLRVAWEHGLADRFSTLLKGAILFGYKKDLEGLRDAGTICPENPHLLEKPAQIREALVTEYLEFYYKECETPCLAFDPPKSLAEMAERRTCHDGKLAVIGESLYPDGPVPKSAKDYTSRICNLDIQMAEVFQSELQVRKGHEACHPTPRFDVFKEALQRKIDCYKVLQPADETLLAERREKWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEK0</accession>
    <name>A0ABR3VEK0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000123">
        <property type="protein sequence ID" value="KAL1840186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF125">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="69"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="500" mass="57853" checksum="58EBD0E82EF30248" modified="2025-10-08" version="1">MTMQNGFETASFEPKRDEDDAPSLDAGPIALIKVGAASLMDKARNASLGSLLWPWTSSPARPERLRPTAYLDGLRGFAAFLVYWHHHELWAHPPPLTQVFETSFGYDGRHYFAALPFIRIFFHGGHFAVAVFFVISGYVLSAKSLSLIHAGEQAKLADNLASALFRRWLRLFIPVIITTFVYMTVVHSFGMYIELLEKKPHYFRAVWDWFCELKNFSFIFHNDKKGYFIYNFHLWSIPVEFKGSIVVYTSLLAFSRAPRNARLWCQAFLVFYFLYIVDGWYCALFVSGMLLNDLDQLAAKNQLPAWFDRFRPYQQSIIYTMLGVAFWLGGCPANGHDSKDLRKNPGWWLLSYLKPQAVWDVKWFFLYIAAVLFVTATPRVPWLKRFFETRFCQYLGRISFSLYLVHGPVLWTLGDRVYAAVGWPKETRLVQLGHWWNKFPLPKTGPMGLEIAFLLPHLVLLPVTLYLAEMVTRHVDEPSLRFPQWLYKAVTTPRPGRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF16</accession>
    <name>A0ABR3VF16_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000113">
        <property type="protein sequence ID" value="KAL1840434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045241578" evidence="3">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="397" mass="43416" checksum="09527B01754A3364" modified="2025-10-08" version="1">MSSTGLFVLLGLLGLLALVPALAAVTVVPLGLHTRSLESWEVLGNVLLFWPFLLCLPLPFLSCWSRPPLAYIPAAALTWVSWVVVAIFWLVDFGVQVSGRFFAWVDPLLSDEELYAALESDLARLKDKFDHQRSTIANLTSKLDEICAEYNRRRLASAAPARARLVLPTVGFQDTEWRDCSTLVKILVFFVATDLKAVFLRNKVKELQLAIIANDDQIRNLSSTIKDETEALGNLAKQTDEFDSPRRAGLKFKVKVTRNEPFSTVLRIGPPRDTFETVMARARARSQAPVSPAPHRRLVPRLVSPVPSLPRCGIIPRREGPRRRHLGLSGPLALSPLPGPLAPVPLFPRPAAAPPAPLPERGPEVLAGPSQVVLVPAPAPALEFIAPVQQTVAPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF60</accession>
    <name>A0ABR3VF60_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000129">
        <property type="protein sequence ID" value="KAL1840056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="235" mass="26028" checksum="7E40E576876A6361" modified="2025-10-08" version="1">MTDPTTEKVDARISREHGRRYWEGVDATVDGMLGGFPHVSRVDLRGSHNFLAKLGIGSKPGLRMAARVLEGGAGIGRITRGLLLDGIASEVDVIEPIAKFTAALQDTPGVGRIFTMGLEDWEPPCDDDGKPRSYDLVWIQWCVGHLTDEQLVGFLRRCKTALNPDGLIVVKENNTTSDGDEFDDLDSAVTRHNDTFRRIFDEAGLRVIRVELQKGFGALQRQLLPVRMYALRPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF83</accession>
    <name>A0ABR3VF83_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000124">
        <property type="protein sequence ID" value="KAL1840167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="550" mass="59532" checksum="4D6C1CBD1AC66A54" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFC2</accession>
    <name>A0ABR3VFC2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000110">
        <property type="protein sequence ID" value="KAL1840507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="104"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="429" mass="46503" checksum="1C2A4E179F35CFCE" modified="2025-10-08" version="1">MHQPSYPPSQGQPLPSDMHPHPHASPYSAHQMQSLPSMPPPGTPYQDSAPMAGPGALQPGQPAQSGQSADSAQSGSSQSQERPPLNPEQKRQQEINLTPYSSQDDQGRVYSLDVVQQPQRARMCGFGDKDRRPITPPPCVRLIVKDAKTGKEIDCNASSEIEHTMYVLNVDLWSEDALKEVNLVRHTTATPSISSTSPASYAQIEQATPAYSHILPSNRDMGYSPQMPYPPPGQPVSPYGMQQPYGQGFVSPNGTGYQPPNQYYPQADMGLTQLVTSPYGPPRVYDPQFGGMPQRMSIGGNPPSGMFTRNLIGSLAASAFRLTDTQDKIGIWFILQDLSVRTEGCFRLRFSFVNVGAPGASGNGAINVGKAPVLASVFSDVFQVYSAKKFPGVCESTALSKCFASQGIKIPIRKDNPNKNANQDDDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFH2</accession>
    <name>A0ABR3VFH2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38115" checksum="F0D6946AE52C8E59" modified="2025-10-08" version="1">MKVNVLDPATKSTYIDAILAPEVTAVPRLECPKPDTSRYEHLRVTGADSEDGVITYFFALDLRQCVKLLPRLIGSIAETIRFLGPQNCALSIVEGNSDDGTGEVLAALRPSLEEVGVTYYLTTTPINPKEDDRIVALAQLRNLAIQPIIDQANNKTSSSPLAAGRRYSAHDTNIVFLNDVAICAEDILELIYQRRFLQADMVCAMDWTYVGPDPTFYDVWTARGMTGDSFFRIPPDGSWDFAWNLFWNDADIYQKLSAHTSFQVFSCWNGATVFGAGPVLDEGVRFRSARKGECLQGEPQLFWKKIKDAKGYTSRPPDMIKCIPTYDNQYFEPWNVTQPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFS4</accession>
    <name>A0ABR3VFS4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000102">
        <property type="protein sequence ID" value="KAL1840713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="3">
        <location>
            <begin position="71"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="261"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="547"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="73098" checksum="98698A44A5C3470D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGD0</accession>
    <name>A0ABR3VGD0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_7612</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000094">
        <property type="protein sequence ID" value="KAL1840914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="358"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="262"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1840914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="515" mass="56730" checksum="E2E3C3986F15242A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGE2</accession>
    <name>A0ABR3VGE2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="153"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="483" mass="55256" checksum="9F68E1476342A3D2" modified="2025-10-08" version="1">MSSSPGATSGNGSAGTAKPAVARGARKAEKPQHMNGPLYKQANSNVVLVRRVKRKNESPMKQLTRWFVDNQIGFSFNLLALLFLAHGMPRARDYTSKYFNLSYYNPRTGNYGIGWNDGHPILFCVVLLTGLRAATMEYILAPFAKSQGLRKRKEINRFSEQAWMSIYYAVFWPLGLYVYWKSPAYMNLHELWTGWPDRELTALMKGYMLAQLGFWLQQLVVINIEERRKDHWQMFTHHIITSALIYTSYRYGHTRVGNLVLVLMDVSDLALGIAKCLKYLGYHTICDIMFGIFITSWLVTRHFLYMTVCYSVWRHTPEIMPTGCFRGQGDHVEGPFEPPRDSGVRYLLEPLWDNNGLFCYNETVKWSFLSMLLFLQCLTIMWFSLIVRVAIKVVKGAPAEDVRSDDEGAPDEEGEEEDDVVYEEAAPLEEEVGVEEIDLKNWERRAGVRRQVSPISATTAVSLPGHSDRKELLGRIGCDKQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGR3</accession>
    <name>A0ABR3VGR3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="85"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="364" mass="39761" checksum="E423B17649706CAA" modified="2025-10-08" version="1">MAPLKDTYTLPAAADMHVHLRNAPGGAIARLVTPTIRKGGVDTVFVMPNLAPKPVTSVDEAVAYKKALMEIEPGVEYLMSLYLHESVTVEEIRRARGEGVFGVKAYPRGATTNSQWGVVSFEPFHDVLKAMEEEGIILNLHGEVPSNPAEGVTVMNGEARFLPVLRDLAAKYPKLKIVLEHCTTADAVNAVRELGENVVGTITAHHLSLLVDDWSANVHHYCKPSAKTPEDRRALLNAVVTSNGKFFLGTDSAPHDIKSKKPGKGNHAAGVFTQPYALGYVLIALEEGIARGDIPAELVTEDALRGFFSEYGRRFYGLPPATRQIRLTRGAARIEESLRYEGEEGSVEIVPFRAGEETWGVEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH23</accession>
    <name>A0ABR3VH23_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="243" mass="26716" checksum="9DFC602D87B23F53" modified="2025-10-08" version="1">MDDTLSNLVDKIWTKFLAAPQDRRFLIAIAGIPGSGKTTLSQRLTAALNARHAASSPDANANPSQPVAIFVPMDGFHLTRAQLDRMPDPALAHARRGAEWTFYGAGFARLVERLSEPAEGAPPTVSAPSFDHAVKDPKEDDIVVEGWHRIVVLEGNYILLSIPPWSSCIPHYSHKIFVRCPRPTARARLSARHLVAGIARTPEEADRRAVENDLPNGDEVLRLLKEEDVDDFVESVEDGSWGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH33</accession>
    <name>A0ABR3VH33_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="318" mass="35324" checksum="91C686F761BCBCDC" modified="2025-10-08" version="1">MASSPEPENMTNQHDGAAAATPDSPYEPTVADVLVTKAMLSKALPLEVVNIIIDLAEYWPHTTTVMTDASSARGSSKHENVFVLRSPPLGLQSWSRSPLAWHGTAPKAILPLPRPPGEDFSADDFCRIVGLPTGLLVHPCRRIVFTFRSYDQGWGGNAADRGTYRGSWTWFEVGLERWCKNSPARSQQQQQSEQRPSLGVDDLCTVIPQVQPRSNGNGYEFVHPLLPAPDLKIQCNVTVSDSVREHRIVWTYTDDIDPERDVQAADALEEQGRGRATGNGKFVRDLKLGDVITVWSKARFPGWANHVQYTELEVYYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH96</accession>
    <name>A0ABR3VH96_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar import and degradation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22792" checksum="24C4667B894A6555" modified="2025-10-08" version="1">MRVLTPAPSLYLQPGSRFVGTQQSERQRYDVDVEIKHVDMRESFLCGYLKIQGLTDDHPTLTTYFEGEIIGTKYSFITQHPSWGATERIDLSHWSKFSAFRPYHKQARKVHPIIPNPDQRENIFMRWKEHFLVPDHRVRTINGASFEGFYYICFNQLRGEVNGIYFHSKSEKFQQLELKYVDNKGCFGAMEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHI2</accession>
    <name>A0ABR3VHI2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="15"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="516" mass="57349" checksum="7CF4F6A16F104BD1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI26</accession>
    <name>A0ABR3VI26_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000090">
        <property type="protein sequence ID" value="KAL1841015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="171" mass="18939" checksum="786C68B4EA3E2EF4" modified="2025-10-08" version="1">MSSASNRQQIRECSQAMCWIQHCQKPPAYGTGSHVQTAEAKHHHIPEPLATTSDSKDKDGQENSEKVRDTGCGITNLDGGEDKKALSSIVTHTGSTEDGDPEQESELEYVRNGESPPPRSMSASSVDSDTNVERRMEDGRRNQRKTRLWAQDQILGSGTWTHLRAFLCGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI79</accession>
    <name>A0ABR3VI79_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="16">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_7725</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="16"/>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF11">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045045018" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="261"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1840826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="297" mass="31378" checksum="64AC3E4F93374CC9" modified="2025-10-08" version="1">MKGLLSFAALSLVLGEASAHYIFQQLSTGGTKHPMWKYIRQHTNYNSPVVDLNSNDLRCNLGADSGRNTETVTVAAGSSMTFHLDTPVYHQGPVSVYMSKAPGSVRDYDGSGGWFKIQDWGPTFNGGNAQWKLDDSYTFSIPSCIPPGDYLVRIQSLGIHNPWPAGVPQFYISCAQVTVTGGGNASPGPLASIPGAFKETDPGYTANIYNNFRSYTVPGPSVFTCSGNGGGSNPNPNPGNPGTPTTLITTQAPAPTTPPSCTVAKWGQCGGQGYTGCTNCAAGSTCNQQNPYYHQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIQ3</accession>
    <name>A0ABR3VIQ3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000066">
        <property type="protein sequence ID" value="KAL1841707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="459" mass="48368" checksum="B912DDC4D3D83F6E" modified="2025-10-08" version="1">MANHSVGGPSLAQARNTRPTPENHHHHHHHRRHLDGNRKHLHLQHGRFQTPEDGTVPPHARLPPSEKQLHGRQIVIVQTVSVVHYVDAAGAVTSVKTLTSDPAALTSTVLPAAFPVAGTSAVSDASPSVSFSAEFPVPTDGAPSTSSSSSEPESTDSAPEPTSAVSTPFELLTSITSADSIPGSSTSALTDTSETSSTTSATETAVVGPSDNGADIGAGIQSPIPPPAEPSSEPSSGLPPQTRNTVIGGVVGSVAGIALIVFALLYLLKWRRHRSRGIMLLTDADSTVRRRPSTAGSGDLARKRSGTFSVHAALAKFNSWKTSITPAPEPAPQEKGFYRVSGKKLISVLESGGDGYSDPIFDSDTRNPQSAFYRDSQMSMFTSNQPPLKLGSPMRPESGVPIFREGPQRTAVQEQPPFSAQRRSTFPTTIPIPVPDSIGRTLASRDGSRGSGSRFMENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIS0</accession>
    <name>A0ABR3VIS0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_7027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000074">
        <property type="protein sequence ID" value="KAL1841472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047053632" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="3">
        <location>
            <begin position="825"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="981" mass="108805" checksum="95F2992B98CE29DE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIV2</accession>
    <name>A0ABR3VIV2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000069">
        <property type="protein sequence ID" value="KAL1841633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="376" mass="41727" checksum="F941F14D05B0DBDD" modified="2025-10-08" version="1">MEEPPELQVPGIVHPLKLFDIAKNEKRFLYTSAPMKLAFRQTVHAYGTDLCWTPMILAKEFNRNRLARDSDFTISTVAPQPPTVVQFGANVPQELARASSLVAPFCSGVDLNCGCPQSWACAETLGAALMERRELVRDMVVETRDQLRRDGWAVGKDSDMDHPKGRSVSVKIRVHKDIRKTIDFITTVLGPEQDRNIDFLTIHPRTRQTPSSIPINLEALEVLTSTFGDKVPIILSGDVFAMDALPFTSPLLPTSTITINTDPKHTTTTTTTTTTNDNPLIITPPLLKHLPKLRGLMSARALLRNPALYSGHSTCPWAAVQDFLYFAARAPLPHKLLLHHVAEMCSPGMGPDKRALLTKAERAELWTCGNMLDLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIV6</accession>
    <name>A0ABR3VIV6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6763</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045871558" description="Glucanase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="456" mass="49035" checksum="665ADEBA33EAC6C9" modified="2025-10-08" version="1">MLLAILALTDLLGLATAQQAGTVTTERHPKLAWKKCLASGACINIQGEVTIDANWRWVYDKETYADCHTGNGWNKDVCRNGQSCANRCALDGADYAGRFGVSTCGNSIALQFVNDGADDSTNIGSRLYLMASPTKYQMFTLLGNEFTFDVDTSRLGCGMNGALYFVSMDEDGGMAKYPSNKAGAKYGTGYCDAQCPQGSKFINGEANLENEFGSCCSEVDIWQANAVSTAFTAHPCETTNQHRCEGDNECSKACTPDNGCTLDPFRLDHHDFYGPGARYAIDSTRPLTVVTQFVKGSDGGLAEIRRFYVQDGRVIPNVGITGNYSNNNNNNRNSGANSSSSSSSSSSSNSTGSGMTGSFCRSAGNSDAFVEKGGMAKLGKALAESMVLVMALWDDYHPNVLWRDSSSATDLPGSECDVTVGVPAEIELEENRQVNRNYVIFSNIRFGPIGSTFRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ61</accession>
    <name>A0ABR3VJ61_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="693" mass="75826" checksum="E7A078D144A57780" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJA5</accession>
    <name>A0ABR3VJA5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="119"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="378" mass="42463" checksum="3016820F9A816D10" modified="2025-10-08" version="1">MRMPKRRDRSLSHLAPSLSAHASSQVSDPDFDPVHGAILAPILRPRVPGTEGHTRVQEHFAAFVRTHLHPSWRIEWHNTTATTPATGKEPVPFRNLILRRDPPWRTAQVEGQGKEEGNVARLTLAAHYDSLYQPEGFIGAVDSAVPCALLLYVARAVDAALTRRWESRTEDDVGLEDEDELDKGVQILLLDGEEAWVEWTDTDSLYGSRALAETWANTAYKPGSRFSTPLEAISLFVLLDLLGAPEPTVPSYFPKTHWAYRGLGRVEARLRKLGLLETKPRAPFLGDTSKEAVQFRGYVLDDHIPFMRRGVDVLHIIPSPFPAVWHTMDDDAEHLDLPTIRDWARIMTGFVAEWMDLEGYLTEPGAEPESGQDEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJE3</accession>
    <name>A0ABR3VJE3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="447" mass="47579" checksum="1B944F0236870B90" modified="2025-10-08" version="1">MSLTNASPADAAQAAKSASHILATLSAEARNEALTAMYDALAAARDDILAANARDLELARQAAADGKLSQSLVARLDLGKKGKFDDMLKGILDVRDLEDPVGRVTLRTRLDHGLELERVTCPIGVLLIIFEARPEVIANIAALAIKSANAAILKGGKESTESFVAISRVISAALDKTQVPNDAIQLVTTRDVISDLLSLDRYIDLVIPRGSSDLVRHVKNSTRIPVLGHADGLCALYLDQSADPALAAEVIVDSKTNYPAACNSLETLLVQDTALSTLLPGVASALAAKGVELRCDPASKAALSSVPDLKLVDATDADYDTEFLNLTLAVKTVSDVDEAMAHINSHGSHHTDCILTSDAQQAERFMAGVDSSGVYWNASTRFADGTRYGFGTEVGISTNKIHSRGPVGLEGLMIYKYKLRGHGQVSATYGEGEGKKRYLHERLPLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJJ3</accession>
    <name>A0ABR3VJJ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1910</name>
        <name evidence="11" type="ORF">VTJ49DRAFT_6133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000178">
        <property type="protein sequence ID" value="KAL1839046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="57385" checksum="4083974011C7AFCD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJL5</accession>
    <name>A0ABR3VJL5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein L10e/L16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000067">
        <property type="protein sequence ID" value="KAL1841691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27352" checksum="D44417AD8C6BD6AC" modified="2025-10-08" version="1">MRPNTSSALLSAFRALRISPTTPLRPSFPAAAAALRPALPPTTTTPNSHVRLFSATAIRAGTWLEPNIPRKKKMRKGRPRVPTGGSTKGTTVVWGDYGLRMCDHHRRISAAQLKMAEDTIKQRLRGQKFRLYKRVACNVGVFVSGNEMRMGKGKGAFDHWAARVAVNQVIFEIRGLVHEQVIRDAFRLAGNKLPGQYEFIKKGDPPVVGITKLEGVTLEELKQPWKKFRESQAASSAPSTTSSSASPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJX2</accession>
    <name>A0ABR3VJX2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="14">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_6414</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="14"/>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1348"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1382"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1411"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1457"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="235"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="376"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="1234"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1529"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1580"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1625"/>
            <end position="1635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1841892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1664" mass="185225" checksum="A2588169C267944E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK81</accession>
    <name>A0ABR3VK81_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="506" mass="56922" checksum="83C7071453435B3C" modified="2025-10-08" version="1">MTSSALAPGHPPQSTTPGVRKAHAPGTCPADPGKPSLAALPYELQAAIFEAAAAGPQVIFMDIANNQLTFSPPADQVLSRVCRLSREIYLKGKMLHRFGQRMFWLNRYRDIFYLRSDDPVPRLLRPTTQELPPVPVGDAFDRRLVHNVGVDLQYLGHFPRHDAVIRVWSVFPYLTAIHIFVPKGPPRTPALQCAPETLMLSTIPSAQVVAAPGHDKELWLAVRYQIRKVCTRIMASDHGWLGRTLPDVVGHFTSLLDNGSSSNSSSNNDQTDNSENIGNVPPRTHRYERHLYLTDPPQPGIHEVRRRTTTTILPAPDSPPARPPSTELIILRPPPPPAVIHHHERHEHHEHHHRQPSPPTFITVEVDTSAPAPARKKKSKSSRSKERSRSRSRSTSRARDREVIIERERVVPVRVPVPYPVSYPVPVLPPPPPPLAPAREPSPKPRLLELGREFRYVEGASRKKKSSSEADRDSGLESVRVRFREREREREHGFGEGEGYRYVFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKG6</accession>
    <name>A0ABR3VKG6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_6469</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="15">
        <location>
            <begin position="297"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1841870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="418" mass="43519" checksum="E3690CED58FFD9C9" modified="2025-10-08" version="1">MGAADRIAQIGNQITGGATKGKAAILEKRPDDIVVTAALRTAFTKGGKGAFKDTLACDLLAGALKGILERSKLDASLVDDIVVGNVLSPGSGATEFRAAALVAGFPVSTAVHTLNRQCSSGLQACVDIANQIKTGMIEIGIGAGVESMSNNYGPGAVGEFSDLLESHPEAANCKVPMGILSEQMAKDRGITRATQDAFAAASFQKAVKAQAAGLFKEEIHPIKVKYTDPKSGETKEVVVDKDDGIRDGVTVESLGKIRPAFAKDGSIHAGNASQVSDGAAAVLLMKRSTAERLGQPILGKFVQASIVGVPPLLMGVGPWKAIPKVFELTGLTKEDVDIYEINEAFASQCLWCANELDLPKERINPKGGAIAFGHPLGCTGARQVSTLLYELRRTGGKIGLTSMCIGTGMGMAAIWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKJ4</accession>
    <name>A0ABR3VKJ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="277"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="596" mass="67572" checksum="F0628C2E886A04D6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKX5</accession>
    <name>A0ABR3VKX5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000040">
        <property type="protein sequence ID" value="KAL1842544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="568"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="705" mass="77282" checksum="63EDC1E69A4CA86E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLA5</accession>
    <name>A0ABR3VLA5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF5">
        <property type="entry name" value="ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="268"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="648" mass="69812" checksum="F02D75DD5F48B674" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM55</accession>
    <name>A0ABR3VM55_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1369" mass="144374" checksum="C19299873BAE70AA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMV4</accession>
    <name>A0ABR3VMV4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-xylanase</fullName>
            <ecNumber evidence="9">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_2564</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046855604" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="111"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1843233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="389" mass="42419" checksum="95239E11EA02C8DF" modified="2025-10-08" version="1">MRSLAVALAAVPAVLAQSQLWGQCGGNGWNGPTTCVAGATCVKQNDWYSQCLPGGNNNPNPPPPPPPPTTTQQPQQPQPTGGNGGGGNTLNEKFKAKGKEYFGTEIDHYHLNNQALLNIARTQFGQITHENSLKWDAVEPSRGNFNFANADRVVDWAVQNGKLLRGHTLVWHSQLPQWVQNINDRNTLIQVIENHVKTVVTRYKGKIYHWDVVNEILDENGGMRNSVFSRVLGEDFVGIAFRAARAADPDAKLYINDYNLDIANYAKTRGMIEKVNKWVSQGIPIDGIGSQAHLAGPGGWNPASGFPAALQALATANVKEVAITELDIEGANPNDYVTVMNSCLQIPKCVGITVWGVSDRDSWRSQNNPLLFDGNYQPKAAFNALMNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN30</accession>
    <name>A0ABR3VN30_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="239" mass="27399" checksum="D42A9FE1B9BE8EF8" modified="2025-10-08" version="1">MAYRRPYNPDELPSIFSDSYRPQQSPRQPGPPDRFAMSPPPAPSGSRPAPRPGQLADSRPPPSPAPRDSSADPTLLPLFRAVDKDGTGQLSERELSAALVNGDWTAFDPQTVRMMIRMFDSDRSGTIGFEEFCGLWSFLASWRSLFDRFDTDRSGNISLDEFSNALVAFRYRLSDRFVELLFRTYDKRNEGVMSFDLFVQACISLKRMTDVFKRYDDDRDGYITLSFEDFLTEILRQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN59</accession>
    <name>A0ABR3VN59_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="386" mass="40955" checksum="1887500DF1B35DF0" modified="2025-10-08" version="1">MSISRAFTTRRVKQSMQAAEDERGPIRSNSARGPAGSLRHKISSPIELVHTTNMLSYNAPDIVPMSASSAGSSPRSDDDMSDSAVTNGTTPPTSPDVDSPVKRSMSPEPNHLSSFFTAVPARPQRQQQEQSTSTSSSTQPSSSSSSSSSSSDQPPVIPQRATSHSKKPYNTLVRQRSASQVSQQSQRTVSTKASFSFSRSSSTSTSTSVSSSVTSPMMTHKSQFSNATIPSAPSSSSTPSTPASPPRSPPRSRPVGPPPSRSASLSQLKLHAKNFSTSESQQHPFGPELAQVSELAEEYGVKEEVVREQLPPPSSSKPRQVDGDEQDMLRKGLLKFSADEYLSEVVRPLFASFMLPPPPARLGGMASPPPPAPVPVVEAVGGGAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNJ4</accession>
    <name>A0ABR3VNJ4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11985" checksum="A5440FE3838F49C2" modified="2025-10-08" version="1">MVNVPKTRKTFCKGKDCNKHTLHKVTQYKAGKASAFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKIVLRLECSSCKTKKQLPLKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNR3</accession>
    <name>A0ABR3VNR3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="191"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="836" mass="89735" checksum="DF3D8B975A681AED" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP08</accession>
    <name>A0ABR3VP08_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma interferon inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23967" checksum="C9C37651DBA63049" modified="2025-10-08" version="1">MDEKHPTAPMLLPSRRGLQPLKLVLSVAAYLSLAALLYCSFGPRVVLPLYGAPVVDSPQEQSPKVEGRLVPLEAHIMSKCPDAKDCLRDLVLPAMQKVHDKVNFTLSFIGKPTENDGVACMHGPEECLGNIIELCAQHLYPDPKTFLGFTMCLTRDYAEIPQRELIEDCALEHAIDFERLNECATKDNSAFGIKLLRESVNRTAKVYFISNLSSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP32</accession>
    <name>A0ABR3VP32_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="572" mass="61288" checksum="DA26E0CD6EFD287A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP78</accession>
    <name>A0ABR3VP78_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_2581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000021">
        <property type="protein sequence ID" value="KAL1843250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="433" mass="47975" checksum="16F824F228BF16AB" modified="2025-10-08" version="1">MPVTTFEFEEKYQYQNGFDCYFEYAHSSSSAVPGALPVGQNSPQKPPLGLYAEKLSGTAFTAPRHENKQTWLYRILPSCSHPPCAKEPLARSLRARPFEHEEYYEILFPDVIGSGGAPKRLTKPRRKTNTDAITAPEEADAPGTAIMDLLTDTAYINPSQTHMTAPAMPPAMPAPMTAHPPPPPPQQPQHQPHQLLQQQPPQQHRVPQNAMPPPPPPRSSVSSASALTPPEETALQSRKRLQAPDGNPNATTAHGPDKRRRTVGPGYMDLTQQRQQQQQQQQQQQHQQHQQHQAHPQHQQQPQHPTSATTSISQTNGATTNSSQASNTTPSSLTTTTAAAATVIPPATLPETLHLLAEAIRSATRGGRPSPGWQEQAMDIFFRDFAAEDMDLQLKIAEKVLTDENKAMVFCKMPDSLRHHWVKRLREVHNRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPJ0</accession>
    <name>A0ABR3VPJ0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="668"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="773"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="775"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="915"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="929"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1026" mass="111548" checksum="46A4F93EEDC0AEDE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPP3</accession>
    <name>A0ABR3VPP3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7511</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="4595"/>
            <end position="4812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3420"/>
            <end position="3443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3931"/>
            <end position="4476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3962"/>
            <end position="3971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4024"/>
            <end position="4044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4056"/>
            <end position="4067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4068"/>
            <end position="4094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4105"/>
            <end position="4124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4130"/>
            <end position="4140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4148"/>
            <end position="4170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4171"/>
            <end position="4181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4182"/>
            <end position="4198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4208"/>
            <end position="4221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4229"/>
            <end position="4247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4333"/>
            <end position="4356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4364"/>
            <end position="4386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4429"/>
            <end position="4444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4450"/>
            <end position="4460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1843801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="4822" mass="536078" checksum="EFBD5403E9861B6F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPS3</accession>
    <name>A0ABR3VPS3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="641" mass="71894" checksum="B3ABB3D406654BE0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPU4</accession>
    <name>A0ABR3VPU4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="502" mass="53508" checksum="CC5079A9C4C86957" modified="2025-10-08" version="1">MSHILVPGSSIDMPWLKETGHLILWRQSLRCARRFADLIATPFGLSIMASAVDPRTRKRVLRVIFVSLLLDLVSFTFILPLFPKLLEFYRNAEVPEDGSEPQTKTLLASVLGYLNAYKAAFARPIDSRYDIVLLGGALGSLFSLLQAIASPIIGHLSDKYGRRTALLASMAGNILSVLLWVMAVDFRTFLASRIVGGLSEGNVQLATAIATDISDASSRGSTMALIGACFSIAFTFGPALGAWLSSIATVAANPFATAAGVSLALIVTETVYLYFCLPETLPALTGGTKPTEAKKTQPTPTPTSIKRTNSHTLLNTTHFLFLLFFSGMEFSLPFMTWDLFRYTSSHNGRLLGYVGLVASILQGGVTRRLHPLLSVRIGVGACLVAFALLARVQTVGGLYLAATCLAATSATVVTGLNALSSFEASEGERGGKLGVLRSWGQLGRGLGPVLFTSVYWWAGRETAYVMGSVGMAGVAAMAVGGLRTPPGSVKTKVGKEGDKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ40</accession>
    <name>A0ABR3VQ40_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="182" mass="19867" checksum="3AF90667B01EC2FB" modified="2025-10-08" version="1">MEIEGKGDSGSMMYGRVSMCALASIEGTDVVWRGREAAAANGDVGGGEARDGGYKNREVDVGDAGDGVETRESRWLEGICLVVESSKQPRQFGFGVGPPVFFLMRRGSPGQQPTCSPETDSGLTETLEGPRNGTHLADYDAAMLWREYGYRVMFRGRGMRSRNGDHVLTPCRYKNESEGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQL8</accession>
    <name>A0ABR3VQL8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11030">
        <property type="entry name" value="CYP105-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF6">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45778" checksum="5A137DDE08D57704" modified="2025-10-08" version="1">MSEPTSVTAPRFPFERASGLDPPAEFARLRREDPVARVSLFDGSLAWLVTKHRDVCQVATDQRLSKERRRPGFPEFNEGGKLAAKQRPTFVDMDPPEHTRHRGMVEPWFTPAKVQSLRPYIDKTVNDLLDRMKSRGCASGPVDLVEQFALPVPSYIIYTILGVPFEDLEFLTQQNSIRTNGSSTAREASAAAQELLRYLNELADKRLKEPKDDLVSQLVTEQVKTGNLEMADAVQMAFLLLVAGNATMVNMISLGVVTLFQHPDQLAELKADPEKWAAPFVEELCRYHTASAMAIKRTAKEDVEIDGQTIKAAEGIIASNQSANRDEEVFERPDQFDMHRKWPKEDALGFGYGPHRCIAEHLAKAELTSVFTQLFKKVPNLKLATAIEDIEYTPRSRDVGIVKLPVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQS2</accession>
    <name>A0ABR3VQS2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1844176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="129" mass="14495" checksum="BF000C30F9A9DA97" modified="2025-10-08" version="1">MAYGRRAGVRTADSVLGWLEIWDYAGGSSFRGFVAEDINRDAKTMFVFFDTHSVSRDLKQALVALIELAEGPLACSHMVICIERSIPEEESKGLTRGLQWAGFSLTTMDFWSKGFDVLSSRWIFMGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQV6</accession>
    <name>A0ABR3VQV6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2361</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="174"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="361"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="453"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="545"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="637"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="711"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1233"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1265"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1285"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1316"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1844304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1325" mass="144232" checksum="21C23C44D9E002DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR52</accession>
    <name>A0ABR3VR52_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046382075" evidence="3">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1844031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="244" mass="27035" checksum="16122855E1D76B13" modified="2025-10-08" version="1">MAATPIRLSFSGFLATTFDAVLVLEAALNNRIHIHQRPLTQEELEPLVHSGAIFVCGVGGDAGDITDWKDGRRWSPPSAQCVQGNPTGFNLYRELLEPGMQRPTEELNYEQDHAESLAPFLGAHVANEMAKPFGLMKKTINFTISGEEYAVISYYTIADVLCGMLPRPRHRYDWDDFAVPPRQEFWEPEAQALIITNDNAEAAAPDTRGWMVVGLVPPPRFASTEAEDADGEEDSTSDEEAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRB5</accession>
    <name>A0ABR3VRB5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="316" mass="35674" checksum="B109292A501DFDC8" modified="2025-10-08" version="1">MASDRSNHHQSALNSMASTEIEARIAALVARELECTRKHRELEARERAVAKRETDIAARERAVAKRQADADNREASLRMRAVELDKQRQKAEIEQAKLATSTNELAQLRDDMVQLRMELREDRVILEQARAELHEDRAIIAQARASAAKEFAALDEMREEAEQTMAALDDIRQKAEKAQGSLMEWMARASQTDSSLTGHIDQLTTQLESQPSHPNIEAQISDTCTAVQSLKHDIAQVMAGLVRVQWTQNVRGKDIDRIRAAVRQGVTTTRDTRCEVLAAIETLTMDMKAELMPIFTSMMNVGIPDPNNPRKRRFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRD8</accession>
    <name>A0ABR3VRD8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD dependent oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046894674" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="52230" checksum="09A2FC3CE15B4DD1" modified="2025-10-08" version="1">MHFTMRTLVRLGCLAALTGATGVHCRCTQTITRDVAIIGGGASGAHAAVWLRDHGHSVVVVEKASQLGGHTAAFKDPVTGKDINVGVQTWIEYENSFDFPARMNVSTSGAMEFTPNTPNFVDMKTGRRVAGYEAPAEAAMYPAIQRYVDAISAYEDIMLPGFFNFPDEIPEDLVMPFGQFVEKYDLYDAVPQLWDSTVMGVGDPMNVPTFFIVQASAIPMARALLGTAAAAVPDSGRLYDLYESIANFLGNDVLYSSKVIKSTRTNSGVSLTVSGPRGKQTCIQAKRLLIAIQPTPSNMAPFNLDREERDVLGRFRFPTVYAGILRHPALPKLNAYSNRSPTPGGLNHTVFPVASQVGHIGYIGGTEDLFQFTAVGTQQETASSMKLRIGKAIDAMIAAGTVERPKLQPGVKPHVTFAAFGDHGHMHAQVSAADLRDGFIKKLYGLQGKRNTWYTGAAFSSGFSTILWEYNKVLLPKVVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRP8</accession>
    <name>A0ABR3VRP8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_19</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1844340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="357" mass="37442" checksum="0C602F785B63D3DE" modified="2025-10-08" version="1">MEETKALNALEPFLALTKSATSPRAASDLVTRATSAPNTYIFTELLQAPQIQALASSEFAPYLTLLEIFSHGTYSTYTSTPGLPELNDAQRLKLRQLSLLTLAKTSNDGAAPTLDYASLQTALDLPTPQALEELVIGAVYAGLLKAQLDPKASRVRVNSVAPLRDVAPHAIGSLLSSLQAWAGRCEATLASLSCQMTQLRADADRRAARASARAQETHRLMEEEKKGGRPPANNRRTIITVAGGARDNAAVAAAHSSATLSSNTHSSTTTTTNSNETSSMLMVGVGSSSLVAPPPVSGNNSGTIATNDAGPSTGAANLQVNPTDEVGDMDMDVDPDVEKATTTDGTQSRSNKRKLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRT4</accession>
    <name>A0ABR3VRT4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_40</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="202"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1844361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="282" mass="31984" checksum="0AD456BC22E8711D" modified="2025-10-08" version="1">MATTTAPSQPTNPPDPTIHLAARLLSHTSPRYTFSFTPFLQRTYRHTLASDRPGGDDTNTTTANNGTTTTTTTTTNDQPNPNQGSGGSSGFGSLVCKHWLRGLCKKGETCEFLHEYNLRKMPECNFFVRNGYCSNGDECLYLHVDPSSRLPPCPHYERGFCPLGPRCDKRHVRRRMCPYYLAGFCPDGRMCREGAHPRWVADKDLEKPRARDEVDGEKVEEGGQQAQQQHRERELELRGRDRDRDGERDRDRGHEGGRHKDRGGWGKGGRWRGKGGRFRGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1A1</accession>
    <name>A0ABR3V1A1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000612">
        <property type="protein sequence ID" value="KAL1835542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="237"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="41891" checksum="6F836ED0A6DCE10D" modified="2025-10-08" version="1">MDPHRPPDTHGLPGLLQPTVQPTAPYSSRPPSPPYIHVPPAGTSPPTTLTNPYHPPNSTSSSARQSRATTPIPTPSPDFPATTSRPPGQGQGHGPSAVVMTIHPSPYAVHTTGLSADQLQIITRGTPQSAQDGSATWQYESRRAAQQVLDFLWLGPASCVRDRAWVESVGVTMVVCARDARFATTSSGSGSGMGEGMLVAGVKRAVAGMGVEVEGLDVADGRELVGAFSVAAGVVNRHMLEVAARSGGRRRGCVLMVCETGNDRSAAVVAAYLMAVYGLDTVAAVQFVQLCRFCVALGDDLKFRLRAYEDILRARGDVGASGDGQVQLQQQQQQQQIGGTPPQENGRVSGAGKAKRGIEDVMMDDGDGAGGGGEDAMAVDMDDERYVGRSFAPFVEREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1A4</accession>
    <name>A0ABR3V1A4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000604">
        <property type="protein sequence ID" value="KAL1835564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="383" mass="42254" checksum="7C0A91895FFFF751" modified="2025-10-08" version="1">MKNAAVRAVNSLVFSPEETKYLKAIFRWTESHLPSDDEAEQRRRDEEEKRKHQLQQKPAGELHILVIGAKGAGKTALLTRFASGTFGNDPALPDPLYEHGCRRPLELDEPDDFVPSPPGTSGTAGTATTATTSTRNPLKQTQGNPQTYMLNALEMPSKNLHSNPLLAQALSITEGAALLFSVRDEASLRLAQGLAEFMREHFAPPDAAELAGSMTATATPNRHHPSRGRPYPILLVGTKADTLPPPNPNAYTHLPSPFVSPTQTTRKISYSQGCRAAAKIPMPNTPVPTRYMETSALTGEGVDEVFAVLGREVLRARRMVREQRERMRQLSSAAVERDGEGLEEGRDGIGGRMWWFARWLRRRGPKRPSRKRSANEAVVLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1P4</accession>
    <name>A0ABR3V1P4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000621">
        <property type="protein sequence ID" value="KAL1835525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="208" mass="23117" checksum="49603092570592BD" modified="2025-10-08" version="1">MPYNPYDMRDKNRKLCYLSDDPSHWRSATEHCKRYCTPILDQAKEEGRTTNYGCPPAYLLNDLHTAWINGGVDYSGHAVRYVPDEENRKAGAMWKGMCFKQPLDKMSDRDIIDKVAAAARAAGNPAATNGLATTTQAAITANYKPEFTITAWDHQPLPNDGLNANPCWPSRIAPQDPGFALNTVDAYYGGNQPPYNYKQPYVPGVNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1S1</accession>
    <name>A0ABR3V1S1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serologically defined colon cancer antigen 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000552">
        <property type="protein sequence ID" value="KAL1835730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="7">
        <location>
            <begin position="551"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="8">
        <location>
            <begin position="932"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="883"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="802"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1028" mass="113505" checksum="291BF93A211296F7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V236</accession>
    <name>A0ABR3V236_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000536">
        <property type="protein sequence ID" value="KAL1835791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="279" mass="29199" checksum="D58B66DBC16B6FCF" modified="2025-10-08" version="1">MGSETARRSALGGARNGDRGPWWVPAAKWGRSEAWPELQKLNDSIAKHEISAAVTSTPLGELGIQLHDSVWPLSHPRLFRGISTLASNPSIKVFPDPHTPNSHLLTYLDTIPPNPQLAIGSTTAVPPTPASFRGNPNFLAILNDVLARHAADDPGLKSQAQAFASPGGSSFVIQGQHPRRGGGSGGAGGASAEGGAGGAGVGGWVHLSDSRNPPDFGRIAWPEDILGSVEVDGHGEIIGNFQASGTYRIVTNQGILGLSPFLEAKLIARLREEEKKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2A6</accession>
    <name>A0ABR3V2A6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000512">
        <property type="protein sequence ID" value="KAL1835904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54795" checksum="2A0778DB409E15FD" modified="2025-10-08" version="1">MAPFIFDDDRQSMRLNSADAPDSPESAPAGDAPQQETPASATALPSSQPQPPAAQPPSLAAETARDRAEDISIALEWKLLYPLLLRGHPDPRPEDPRPIAFEPCITSSSSESTSTASPSASSPTISSSSAPDEASINHDHDHDQDSHERARLEQVHTHVASTILSIPDEHAVTLHALRREGGEEKDVWATSWVVKRANSAEPLEQEGKVPGYVWVPVEVCSPRMRFGEARTRARMRDVLGALQAGHRLVANASCEVHVHLGRMDGRAWGLGTLKRLASVLWLAEPTLRRIRDPRSPNFGNVYTWGFAMREQSRLAMLVGKDAAAMCATLEEASMAITDDQIAEAVRAQPAAAPKEVAALAAIWRTTSHLELGRLLSGPEKKYRRLGFNFSAFGEEDERARRNPRTMEFRIMDGSVDTELIVSWLAICGTIVETAVAEGDPRFGAALSLLLGRTAERTPPGDTEAETVGVRLGREFAELMQALEIGEEHYRGFQDKIRREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2I1</accession>
    <name>A0ABR3V2I1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI inositol-deacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000505">
        <property type="protein sequence ID" value="KAL1835925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="298"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="586"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1478" mass="165621" checksum="D9750AB70912D30F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3A6</accession>
    <name>A0ABR3V3A6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathionylspermidine synthase pre-ATP-grasp-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000449">
        <property type="protein sequence ID" value="KAL1836196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathionylspermidine synthase pre-ATP-grasp-like" evidence="6">
        <location>
            <begin position="15"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="469" mass="53602" checksum="670FE5A13E8A0DA0" modified="2025-10-08" version="1">MRRISVQPRPNFTRLVQSQGLVYSNPTPEHPIPYWTDDMYYSFTSEEIELLERATKDVFDMCCEAADYLVDRPELITGRMAIPSFVLKQIIKSWDHEPAWASVYGRFDVCFGGLNNPDPRLRVPKFYEFNADTPTSLVEAAVIQWLWLEQTGHGNDQFNAISEMLVEAWKRNLTLVEKEIGHRFKVHFAIGIGDSSGEDAFNTTLLLDTCQQAGWQTKAICMEDIRLSQRDGRFYDQDGEHIDVIFKLYPWEFMVEQKFGKACFEDMERIGQRNEAGEYVGGTVWIEPPYKMLWSNKALFAILWQLFKDDPRSQWLLPTYFEDEAPASLTKFARKPIFAREGADVVLHADGKVLHDSTTGAYGKEGYVVQELSILPEFKDPQGVSHYPVLGLWMVDGDVAGMGIREDITPITTNTSLFGPHSISDGPVNYERKPVPDLHEIEATLAMEQYTEAPEQTKGVLRYIESIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3B4</accession>
    <name>A0ABR3V3B4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000467">
        <property type="protein sequence ID" value="KAL1836087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046381967" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16759" checksum="E2068D0F487BFF33" modified="2025-10-08" version="1">MHFIKQNLVATAALLALVFPTSVVGQKLGLLEVYTGGQWSCGPVTSGLQIVSFGDTHREPSVECSDADWTVVSRGPRGPDANMDGCKEGVYDGGYRVCITKYGANIHNDKGQHQRCHTDKTNLSACMYKDFYQCMINKIRRLTCDGVWHNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V463</accession>
    <name>A0ABR3V463_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dCMP deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000396">
        <property type="protein sequence ID" value="KAL1836562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="233"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="391" mass="42670" checksum="D7547CAA48DA3CF3" modified="2025-10-08" version="1">MFIGICGSICAGKRTIAQYLVDHHGFTQLYLRSGSHTANGDGPVESTDGAVAVTGDRSENSHTSSRATRRRHFSAPEALLDFVTRHWRDRWVTTDIPSESVLDMYYRRPFFLLLSVDAPLTVRWHRYQARETAATAAEVTAAAIRSLSTLDSSPSSTSLDDGAPATTTTPPPSLTLERFAQLSDAQLYHPTTGTLPLMSRASVRLLNTSSSLAHLYATLGTLDLLNPDRLRPSWDSYFMSLASLAAQRSNCMKRRVGCVVVRDRRVVSTGYNGTPRGMRNCGEGGCSRCNAGEGSGHALATCLCIHAEENALLEAGRERLTQGAVLYCDTCPCLTCSIKIVQVGIQEVVYRYGYSMDGQTAAVFREAGVKLRQFVPPANGLIHLEKPDLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V476</accession>
    <name>A0ABR3V476_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000396">
        <property type="protein sequence ID" value="KAL1836565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="583" mass="62077" checksum="29D6E50EB01FDBAB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4E0</accession>
    <name>A0ABR3V4E0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000387">
        <property type="protein sequence ID" value="KAL1836625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="254" mass="27296" checksum="B4CF01205FED104B" modified="2025-10-08" version="1">MAAALTLTEAQAELISSLPQEDIPAKLRCAICSKLAVNAFRLPCCEQAICESCQATLPASCPVCEHSPLSAADCKPHKALRTTIKVFLRTEEKKRESAKPKETSAPVTPVEPTPTVAAVPSAPEAGVETAQPDRAVEEQAVAGEKAQDAEATEAQEGHDAGAEEERGVAENGADAVRQSIAVCCLGPMLTQTGNRNLKMPKMLPLKRRRPNLSRSMPNPKSLRMALPKPRKGKNPKPSRTNQTPRSLERRPWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4E2</accession>
    <name>A0ABR3V4E2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000385">
        <property type="protein sequence ID" value="KAL1836639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="383" mass="43222" checksum="A033DD60FA1029C9" modified="2025-10-08" version="1">MTELTDLDSGLDDASKHDILSVFGVEVTPPKVSAMAPYFEYFAQELTASAMFDHLSNAETREALKILKLLKAHPNTRKEDIRDPSVPATGPALDFGVRAMLMTQCRTPGVFAGGVFNPEWKPCETLTEFVNRVYPRAEAPADDNYRRGPVVIERMAAPGLKTNVHITIEWTNHLTDHLELLVSADWKRLHVFRYPCYLNMCLKALEADRPNLDHSTEAALALGSLPPALLKETLKTYSLLFPQTDFASQDMLREAMGHDSATLESFGGMSSGHERRQDARRPETIADLYDKFPYWADRLEHLWREVENPRPVTRVERWVDKRKDQRWSTWWVVLGVMLAVLFGITATILGALQVWISYCSWLDDPRVAGCSAKLPVHGEAVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4G7</accession>
    <name>A0ABR3V4G7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000384">
        <property type="protein sequence ID" value="KAL1836649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="307"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="573" mass="61472" checksum="582199B3D6E7635C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4L9</accession>
    <name>A0ABR3V4L9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000376">
        <property type="protein sequence ID" value="KAL1836708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37875" checksum="EE9F2A5A31E4672E" modified="2025-10-08" version="1">MASAQDSPLGLLRKNPLLGGLADVYNAFQERRGRLGLSNPGLVENISKEVQRDVLTTNLMFSGLRADLTKAFSFNPLFQVSHQFAMGERLNPYNFAAIYGTSKVFAQGNFDDQGGLSAAFNWRWNNSFTTKSRFQITPNAAADMTQIENEYMGGDFSAVLKALNPSVLEGGLTGIFIGQYLQSVTPKLALGLEAVWQRAGLTQPPDTAISYLARYKSDNFIASAQLQAQGAFNASYWQRLSDKVQAGVDMTLSVQPSGTMMGGLTKDGITAFGAKYDFRMSTLRAQIDTKGKLSCVFEKRVAPPLTVTFAADVDHFTQQAKIGLGVSIEAGSEELQEHDAQPPPNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4M4</accession>
    <name>A0ABR3V4M4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000417">
        <property type="protein sequence ID" value="KAL1836396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="142"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="263" mass="28930" checksum="D4BFFC043F3FB9E8" modified="2025-10-08" version="1">MSGRPGASSRGRGGKFKKPTRGGGKHFSRDLRPVDADGNEISMWSIDAQHQLAAGNESSEEGSSEASESESDDDAQAGPSSITIPPPQQTELSREERRQQKKARKEAAIARAQRVVQVGDLPPSESEEEDEEDDDDDDMPANPNHSSKARKQAKGGVDEVADGVGGLRFGSDASAPSRREREALEAQAAKERYRKLHEQGKTDEAKADLERLRLIRERREAEAARKQAEKEEKAEQDRIKRAAIEAREAKRREAALGKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4M8</accession>
    <name>A0ABR3V4M8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000398">
        <property type="protein sequence ID" value="KAL1836537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="286" mass="31718" checksum="733406536F2EC1EE" modified="2025-10-08" version="1">MQLSPSHHSAVRRHILSQLEPGLVHRLQGGGTKRQVLAVGLGTGEQNGDVAVVDRQHFVDRCRPADPYRISLFELRPSVRCQHDTQNRKGTRYVPPCWSADGRQTGKRLQVRPLNCQRAMSRSDEVLWCGAWVLLGWRKLGCRVLRLLYCLLCFRCHSQPNRHSTDGRAAPLYTPADRGSDAVHLHACGLTIHHRSSRPPFSSQAPTRYRIPDVPLGPSWFSATTCMACIRAGNSTNASPRIPACLSNGGRRWNHRVGAGAPWRDVTGHGVTAARALQAAGWLAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Y4</accession>
    <name>A0ABR3V5Y4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000372">
        <property type="protein sequence ID" value="KAL1836733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31903" checksum="E1081A421AB2E948" modified="2025-10-08" version="1">MGALDAFRFGTDRWDPTHRFETSWLLSPWALFACRALLSLYAFTTLIFVLAWQCARGSLGCTASQHTFSYFTTLTYWGLAFYFLIAAIHTATYARSGKPLLDRFPRPLQALHSAFYTTIIVFPFVVTIVYWARLYSGRWYPDTYSGWSNVSQHLLNSAFALFEIVVPRTEPPPAMHMLWLIVVLALYLALAYVTYASKGFYTYNFLDPEEQGALVAAYVFGIAVGCLVLYAFAWGLVWLRRWVTETKLGKRGKFSKRDQEAVERGDVRGEVPSKAEVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V678</accession>
    <name>A0ABR3V678_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000313">
        <property type="protein sequence ID" value="KAL1837255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="281" mass="30380" checksum="10A50DA0C344F2C7" modified="2025-10-08" version="1">MADRAEERIRKAQVKGKTNVKLSKEELAAYQRRLQRIEEEKRRKQRRQRVAIPLTAIGGPSRSKKTTPGDSAEESSSASASEDDEQPLPNPRRAQLPAPPARPRQRSTSSKPPSHHASDRETSSSPFTYSYVRADPVTRNGSSPAAALQADPFQFMTAAARTSSYHAGVTARNSIHEVDDIYASYGSGPLAAAVGASRQRSDSSESPIEDAPLDRDRAAVRVPSSGSGNRSRHRESIDGRKEAVPEPKSKKSSSTSTSTTMVVAKRKSVAGSKSSSGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6D5</accession>
    <name>A0ABR3V6D5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000321">
        <property type="protein sequence ID" value="KAL1837175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046421178" evidence="2">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="158" mass="16118" checksum="ED4559A0FDC26110" modified="2025-10-08" version="1">MQLTKALLLATTLVTGVFCAPAPAPAADPRELVDEISVIDGPPGGPRTGVGSGSGNNPPPPPPPPATTSAAAAAAAPTIDWARNCWDDCRWLRCGMGKPCDAMCVWQCMIQWCPHPSGDSALPPPSPTPAGPDTASPPVLPHITPRKHGPSPSANNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6J1</accession>
    <name>A0ABR3V6J1_HUMIN</name>
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        <recommendedName>
            <fullName evidence="5">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2885</name>
        <name evidence="6" type="ORF">VTJ49DRAFT_4335</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000335">
        <property type="protein sequence ID" value="KAL1837046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000023">
        <property type="protein sequence ID" value="KAL1843135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
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        <property type="entry name" value="PUM-HD"/>
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    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="107"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="639"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="687" mass="76405" checksum="4EEF3C60633D8EAB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6S5</accession>
    <name>A0ABR3V6S5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000291">
        <property type="protein sequence ID" value="KAL1837474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="187"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="776"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="816"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="878"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="897"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114681" checksum="7747D1A348544CFE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Z8</accession>
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        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_3259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000252">
        <property type="protein sequence ID" value="KAL1837913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="312"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="527" mass="55675" checksum="153B04963830B742" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V800</accession>
    <name>A0ABR3V800_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000250">
        <property type="protein sequence ID" value="KAL1837939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="708" mass="77876" checksum="AE7F638A05FB9C18" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8V4</accession>
    <name>A0ABR3V8V4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000233">
        <property type="protein sequence ID" value="KAL1838174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="384"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="592" mass="66690" checksum="83B8139261FD38AD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V959</accession>
    <name>A0ABR3V959_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000248">
        <property type="protein sequence ID" value="KAL1837971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="65177" checksum="D7B5A79BAFFD6EB4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V983</accession>
    <name>A0ABR3V983_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000221">
        <property type="protein sequence ID" value="KAL1838333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="31"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="229"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="711" mass="78585" checksum="662D2C9176CDA616" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V995</accession>
    <name>A0ABR3V995_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000220">
        <property type="protein sequence ID" value="KAL1838348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="755"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="755"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="788" mass="89421" checksum="3B7B3A1DCB95897F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9C4</accession>
    <name>A0ABR3V9C4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_2662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000214">
        <property type="protein sequence ID" value="KAL1838439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="107" mass="12219" checksum="6827852731220006" modified="2025-10-08" version="1">MHLMYITDANGTSAGRRYTLKKVLDGQVTKSAHPARFSPDDKWSRHRLAVRKRFAVLFAQHQAKDKAQAQAVLDKKLLEAAEMGAAGAHRAKARDRRRKAHQPRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9E6</accession>
    <name>A0ABR3V9E6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000220">
        <property type="protein sequence ID" value="KAL1838354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="48"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="454" mass="51166" checksum="D07537C8F8DFD774" modified="2025-10-08" version="1">MAELSPPSPSDEKPAVDHNDGKKATILGACKNRDLEALRELAESPGGFLTDTLREQAWPVLLGLSPTDLKTEHPADGETSTPSWKSLPRHRDEDQVQLDVNRAFTYYPNDQTDAQLAHTKSLLSDLIVSLLRTHPYLCYFQGYHDIAQVLLLTLPPHLRLPALTRLSLFHIRDFMLPSLSPAISQLRLIPEILRLADPPLYRHLAGLEPFFALSGTLTMYAHDVPSRAAIVRLFDALLAREPVFSVYLFAAIVQARREELFETAADDTDMLHFLLSKLPNPLDIDALIAQAARLRRDVPPERLRAWRREISRWSVLKTERFRPAQRHGSTTTTTTTSNSKDTAAVSDQNEKDTPDSDPNPDNDPEPIPLPFARQWFDRHVAELQRQEQREKMRKWLRQHRRPAGLGLVGVAVLVGVVAVLVQYQQQRGTTGLPGPVAAGLAYVSRFVAGWWSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA51</accession>
    <name>A0ABR3VA51_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000226">
        <property type="protein sequence ID" value="KAL1838261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12243">
        <property type="entry name" value="RRM1_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12244">
        <property type="entry name" value="RRM2_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="278"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="366"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="573" mass="61573" checksum="62DF6E54D3C006DF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA71</accession>
    <name>A0ABR3VA71_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000204">
        <property type="protein sequence ID" value="KAL1838611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="188" mass="21498" checksum="E42C298430A630A9" modified="2025-10-08" version="1">MSLNVHETNVRRSCEAAKNFADWYYRQANDGKSIASAYVNGHAAYDKAGHPPADICINGRVVATPQEWEQLLEEQRKAPKQPDPNRRRVRYEVETLIAHVINPDYRFGAPASLLDKYSPTDGVRLMLSVLITGTVYFGTGREKGDEYWEKQTFSDSFILVPNWDLLERAPGKQHGRKYLVISHNYRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAL5</accession>
    <name>A0ABR3VAL5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000200">
        <property type="protein sequence ID" value="KAL1838675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="44061" checksum="A6CCB0D548A40D9D" modified="2025-10-08" version="1">MCFGNKKDADGDAPRPAHGYTAHEPEKNNRVSLPPQYQQQQQQQQPQRPVQDYAPPPGPPPVQNYAPPPGPPPSQRPAGADYAPPPGPPPGHRPAGDDYAPPPGPPPSQNYTAPPPGPPPPQHDWESLVPDTSLFPPPPSFFSGFDRSPAHNATEAEAEAGEAWCAAYPLAPPVALDPPAVAALAAHNLRLMQPTVNFKGSLVCTAPGMWAGRTERKSADSTIIAYPPLYTPSLHSPLFPTSNPSGLKTIYYEIQLSPHGNPPPGDICLALGFTALPYPSFRMPGWHRGSLAIHGDDGHRFINDRWGGKAFTQPFRAGERLGVGMTFRLAAGSVVGHGPGRIDVDVFFTRQGREEGRWDLHEETDAEQDLPVTGLEGYHDLSCAIGTCGETAFEVVLDPGRWLYRPVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBB5</accession>
    <name>A0ABR3VBB5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000180">
        <property type="protein sequence ID" value="KAL1839008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="829"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1339" mass="148599" checksum="B872C6C753621393" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBH4</accession>
    <name>A0ABR3VBH4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_1908</name>
        <name evidence="19" type="ORF">VTJ49DRAFT_6135</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000178">
        <property type="protein sequence ID" value="KAL1839044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="127"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="350"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="341"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="631"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="772"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="841"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="666"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="859"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1839044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1842065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="929" mass="102225" checksum="287640138D5FD786" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBM8</accession>
    <name>A0ABR3VBM8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SRA1/Sec31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000193">
        <property type="protein sequence ID" value="KAL1838796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="SRA1/Sec31" evidence="6">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="92" mass="10343" checksum="868D1C33B5DAB1ED" modified="2025-10-08" version="1">MQRVAAKAPATFAPQVRDTQKRLNILFDHINNHELVKADTIEQLTQAAEAMAAKNYDEAARIQTEVLKTKMDECGQWMTGLKRLISMSKATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBW1</accession>
    <name>A0ABR3VBW1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000174">
        <property type="protein sequence ID" value="KAL1839125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="65" mass="7534" checksum="EB75F1E3F43D4533" modified="2025-10-08" version="1">MAKSKNSSQHNQSRKAHRNGIKKPKTQRYPSLKGTDPKFRRNHRHALHGTAKALKEFREGKRETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC75</accession>
    <name>A0ABR3VC75_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000156">
        <property type="protein sequence ID" value="KAL1839454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="537"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
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        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
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            <begin position="465"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="721" mass="79587" checksum="9996F3C3EAE61A52" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCY4</accession>
    <name>A0ABR3VCY4_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">Nicotinamide-nucleotide adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1229</name>
    </gene>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37715" checksum="A22DBE3D195BE779" modified="2025-10-08" version="1">MPPQLPVPARSVADFFCRALSSFQSSQSKLQIICTAVSSQHRRGTDHDEPTLSPPAKPPRTIVVLDSSFNPPTRAHLSMATTAILDLAQKHNQPLSTVRLLLLLSVNNADKGVKPAAFDKRLAMMWAFAGDVLDSVGVREKLAPTTAAERQGVQELSDGGEGLSVDIGLTTVPYFHEKSASLAREGYYHGGSDLSGSEHPPPDQVFLVGYDTLIRIFNSKYYNPPSSTAPVAHFGSTPMRDALDPFFDRARLRVTLRVDDDWGGADEQSRYLQEVLHGDGLEKVGGSRDWGKRIELVEAQSVGADIISSTYARAAAKNRDSDKLDLMVTPGVKWWIEQEEPYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDB0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="292" mass="33389" checksum="59B2A1B6009CA82B" modified="2025-10-08" version="1">MTTPETKSTAEARDPLLRAPVFSGAAFSEPLKEAVLEALWPQTDEEERSGPCPVDDFDSYFEYLEHQCSHERRELHAIQTFDDVIALLDVIKKHQTKSLDHILDMVRATTSNQALSAADEDKLLESIEFVVRCWLMINVCIAPRSSGRWYHIFRGQPLPWPRTDSLSQAIQRSLAVPSTMDHSGVASGDFPDIFNVVDMKKIVGFKVMWTNNLGDHLVVRGRFVYLFSQELSDAFDNAKPRGMRQWLHDRRDMGQWWNYWFIVMGLTLTVLFGLIQSVTGILQVINERSGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDR2</accession>
    <name>A0ABR3VDR2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="9">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="406"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="406"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="713" mass="78912" checksum="D91972AE6099EFBD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDS5</accession>
    <name>A0ABR3VDS5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000138">
        <property type="protein sequence ID" value="KAL1839848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="229" mass="25239" checksum="F4D9CFF9059D14E6" modified="2025-10-08" version="1">MSRALLRSALGLRAPVLRLTAPSVPRATPSLFTPAAAALPTTTAAVRFFNQTAQHVEPTQDPSVLLPSTPSSSSTTTAPSQQQQQQQPPTQQSQPRPLSPTVRALLPILAAQPGHYIRIHIHGRPFLVTEGDSLRLPFRLRGVQTGDVLRLDKASVLGSRDLTLKGAPYVDERLFTCRAVVTGVEAEPMRVMIKKKQRCRRKKHVRSKHRFTVLRICEVRVNGEVVDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDT3</accession>
    <name>A0ABR3VDT3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000159">
        <property type="protein sequence ID" value="KAL1839403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="357" mass="38800" checksum="EAB79AF652ACC88B" modified="2025-10-08" version="1">MADDNGPVMIITMAVLTVVMTVIMGMRFWCKRQMSTKLGLDDAVLFLGYTLHFIFEVISIYMVQFGLGKHMAEIDMVTQLPKLMYWLPIAQWFAIVCIAVSKSSFVITLLRLVTVPWQKAALWFLLITINGSMGSISIVQFFQCAVPPKPGCIDNNAVVALAVYAAAYSAFADLVLTAFPFLIIWDLQMKKREKIGVIVSMSCGVVAGIVGIYKASTIPTVSRSLDFTHSTAIVLIWVVAEVSATIIACSIPFLRPLVRHIKSSKGSKNSYGLSGMSSRATHNKLGSRADAKGGGDTDDGDKDSDRDVQPLTPGVVRRTDAFTVEYDTWSAHDGASQNGAQGPPGSSGPQVSRREMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDV4</accession>
    <name>A0ABR3VDV4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000134">
        <property type="protein sequence ID" value="KAL1839946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112179" checksum="A4763ABD00A0758C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDW9</accession>
    <name>A0ABR3VDW9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000164">
        <property type="protein sequence ID" value="KAL1839326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="732"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="8">
        <location>
            <begin position="911"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1114"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1190" mass="129536" checksum="E442767A31F20E92" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDY7</accession>
    <name>A0ABR3VDY7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000148">
        <property type="protein sequence ID" value="KAL1839621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="398" mass="42382" checksum="DEE4A31884699E56" modified="2025-10-08" version="1">MASTQHHPSHVLLSPAELAYLHDALLLVPPIRPDGRGPNDFRPLVAETGILPGANGSARICFADGTEAIAGVKAEVERTVRRAGDDTVYLEEGGGEEEDVEEGEEVEEKGKGRGEKKGEAAWVELTVEIPGVRDDDSGTVFLAAMLSEALLADGELVGRLWINRRFHWKLYIDIILISPPLSYPLPLLSLTTHLALLSTRLPRLKSEGDEDPFFDDDWAAAPYLFPRSSSSKSQPAPRPPITLLVMAVGNNILFDPSKEELAVADVALAVSVTSSTSQTGKEVTKGKNPSNSPSQSHRSLRLLSIRTIDPPSRLTPPGVANAANAAYGAANLNNLGNNGQQQKAAEARTAETEAVEGVWRAPRGGANRAVLAALVGKVLEKGGIVDEVLDALEAVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEU5</accession>
    <name>A0ABR3VEU5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000117">
        <property type="protein sequence ID" value="KAL1840335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18253" checksum="CB589843A74386D1" modified="2025-10-08" version="1">MGHSHGLRAGTRYAFARDFRKHGQIPLSTYLRTYRVGDIVDIKVNGAVQKGMAHKVYHGKTGVIYNVTKSAVGIIIYKKVKHRYIEKRINVRIEHIQPSRSREDFLRRVKENAELKKKAKAEGKPVQLKRQPAMPREGYTLSIADTKPETIAPVAYETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEZ7</accession>
    <name>A0ABR3VEZ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable alpha/beta-glucosidase agdC</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_473</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000113">
        <property type="protein sequence ID" value="KAL1840435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="672"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="448"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1840435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1754" mass="194946" checksum="0C61B963FD7FB4D7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF85</accession>
    <name>A0ABR3VF85_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="132" mass="14439" checksum="3B2D59F9AA0559DB" modified="2025-10-08" version="1">MAPRALFTILRRSTASLSTVPRRSIITITRPLLGPLKENTTSDPPSPAEIERHKKDSLDKQRSGHAEWKAELASVSEECVKADREEVAGEDEGGFTATSGGSKSGPDAMKRLQERTKGVAEATRKHMEEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFA3</accession>
    <name>A0ABR3VFA3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000108">
        <property type="protein sequence ID" value="KAL1840549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1840549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="137" mass="15756" checksum="C676AC2E140060F4" modified="2025-10-08" version="1">MTDILTQLQEAMDLLCTMFIAGIYYTERHHDLEAFGPNDKIPDLKGDQPKEVETLDPQTYRDGQVEIARDMIVQAQRIEYLVSELPGLQNSERDQLRIIASLEEEIAGLEAQRREAVRERDEVFAQLDALVKSLQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFA9</accession>
    <name>A0ABR3VFA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000127">
        <property type="protein sequence ID" value="KAL1840101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="9">
        <location>
            <begin position="376"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="709"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="782"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="6">
        <location>
            <begin position="407"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="846" mass="95621" checksum="C41F17F8A303D669" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFU7</accession>
    <name>A0ABR3VFU7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF22">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="12"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="325" mass="35331" checksum="C5184B8B581735E6" modified="2025-10-08" version="1">MTRNVCITAVEGQTGFLIAELLLTDAEFKKKIDSLTGLTMDPNSDKVKELKTLGATIATHTPGRERDVAEALKKTGCDTLCLVPPARADKLDIASELIGAARRAGVANVLLISAAGCDYAERDEQPRLREFVDLEAAVLACKGDPSNPLGHSPCVIRAGFYAENLLLYTEQARNEGLLPLPIGDKHKFAPIALGDISLVAAHVLTGKGPHGFDERHRGQLMVLTGPMLVSGEELAAAASKALGQTLEFENISEREAKRVLKSQTDIDDSEKEYLLDYYSLVREGKTNYISTTAFHDVTGQHPTGPEEFFKNYAGELRPKKKLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG34</accession>
    <name>A0ABR3VG34_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_279</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000105">
        <property type="protein sequence ID" value="KAL1840628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="263"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1493"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1531"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1811"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1493"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1531"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1570"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1863"/>
            <end position="1873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1840628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1946" mass="217700" checksum="D87A4A3CFB6D65FC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGR5</accession>
    <name>A0ABR3VGR5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF24">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25999" checksum="003E0D16C13E3CAF" modified="2025-10-08" version="1">MPPTLVLIRHAQAHHNVDRKYHSMPDPELTETGIQECLELREHLKATLPADRKIELIVVSPMRRTIQTCLTALDWLIEAGVPVIPDARWQETQAKPCDTGSPVSVLTTEFPTIDFSSLDPVYPDKTSPAGAAYRWSKPAILARGQSALADLYQRSEDVIAVVSHSGFMRTAVAGRWFQNADYRIFDFEDRTGKDESEPYRLVEWEVTKKNGAMGRSREEPVELGEGLPEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH53</accession>
    <name>A0ABR3VH53_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF3">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="206"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="412" mass="45715" checksum="4FA81DCB9AFAF097" modified="2025-10-08" version="1">MFSRSVFNDYSSEVFDVCYRDRIEDPPMTRDEEVEKRAAAHALVQSKYDTGVPFFTKDVFRDLARQFEANGGPDGKISVTGLDGVTVHIPLKTGQEYPRRPYGDDFVCIVAKPIVHYRGIQNLLDKRPIPAGGDVPFYMNSIREIYLPVDVSHLVEVRDAQTKELVSVLPVADHDTVKQRLDQMRQSLEASEHFAQIRSTLVSVALPSGIAKIVALACSTMTERDPPECSLAQHALVLMLRDFLSRDSSKSGTGSGGPGSTRIQCFAQEPRYLPIDEQVLRENGVTVLDDPGAFVEIDETSVVLSIAPDIPVREIVADIARPAIMIWDKVVVKDKSTLWTDPVTPRVERMMEDYIELPFPPNDELFGDVAIYVRKGDSKVNRPGQAQQVVGEQRLGVSVDAHVEGQHGSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI34</accession>
    <name>A0ABR3VI34_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA ligase</fullName>
            <ecNumber evidence="7">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="10">
        <location>
            <begin position="514"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="594"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="831"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="863" mass="94713" checksum="D6938FEAD93A1449" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIB3</accession>
    <name>A0ABR3VIB3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045877212" evidence="1">
        <location>
            <begin position="21"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="538" mass="60273" checksum="723C221281A8AC68" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIG0</accession>
    <name>A0ABR3VIG0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="667" mass="73159" checksum="1F7B1089B094E59A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIL2</accession>
    <name>A0ABR3VIL2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000084">
        <property type="protein sequence ID" value="KAL1841188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="513"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="733" mass="78763" checksum="423C67521B311D33" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIP1</accession>
    <name>A0ABR3VIP1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000066">
        <property type="protein sequence ID" value="KAL1841719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="178"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="254"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="328"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="391" mass="43822" checksum="CFCC1D19CA5A318C" modified="2025-10-08" version="1">MADHRVSPETAQSDSHSAPPTPAPSSSTAGKSGSGELPLRLGHELQVPAPSSHLRPKPPGRTMSEKTPSSLDKEQMQGLRAIREFLKVRTSYDVLPLSFRLIILDNNLLIRKSLNILIQNGIVSAPLWDSRRSAFAGLLTSTDYINVIQYYCQFPDEIDQVDQFRLSSLRDIERAIGVEPLETVSVHPMRPLYEACRRMLKTRARRIPLVDVDDETGHEMVVNVITQYRILKFIAVNNEKHTMLLKKSVRDIGLGTYSNLATADMNASVLDVIHLMVKYNISAIPIVDKDYKVLNVFEAVDVIPCIKGGAYDELSSSVGDALTRRADDFPGIYTCSEDDRLDAIFETIRKSKIHRLIVVDDDSRLKGIISLSDILKYVLLYGEEDDVIQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ21</accession>
    <name>A0ABR3VJ21_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAL1841898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="191" mass="20297" checksum="8F41F019BCDF2FC1" modified="2025-10-08" version="1">MAPTIPPPTSPSPPPPPSDDIDDIPLILREQTAVLTLFLAISLLLLGAVFLGDRWSRVKGSSSSSLSSPTLSPCSSPAPKSRKRRRTDEEADGRPSEMTPLLSSESTLIGPELEQRIDEDKSNDLSEQPSPTLSAGSGISGGKCSYGSVSWDSDGATVPMEPELEPETEEGLGGRSDSARLGSRRARRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">VTJ49DRAFT_6697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000066">
        <property type="protein sequence ID" value="KAL1841723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="BOD1/SHG1_dom"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="45"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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            <begin position="1"/>
            <end position="14"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
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        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
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            <end position="512"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841723.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="747" mass="89663" checksum="F086E8E4909BE553" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OS12G0136300 PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_TACC"/>
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    </dbReference>
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            <begin position="788"/>
            <end position="803"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="803" mass="86401" checksum="5731ACDF79A8E055" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJG1</accession>
    <name>A0ABR3VJG1_HUMIN</name>
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        <recommendedName>
            <fullName evidence="9">Importin beta-2 subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">VTJ49DRAFT_6330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Henrissat B."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1841939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IMPORTIN BETA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="105353" checksum="10BE171ED0E51E4F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJI1</accession>
    <name>A0ABR3VJI1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_7412</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047483388" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL1841081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="234" mass="25015" checksum="F01095811F5397CA" modified="2025-10-08" version="1">MKILPSLLLMAAGADAHYRFSKLIINGTPEPREWMAVRQTKNYQGNQGVTDVNSPDMRCFQMRPGTTTATVAAGSKLGFVAVSSITHFGPVSFYMARVPNGVDINTWEPAGNVWFKVAEISAVPAPPGGQLTSGEATWPAYNKQSVEFTIPPSLPSGKYLVRVESIALHQAQGVGGAQIYLSCAQVEVTGGGNGVPGPLVAFPGAYRANDPGLLWSYYPVRTSYKAPGPEVWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJY3</accession>
    <name>A0ABR3VJY3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000051">
        <property type="protein sequence ID" value="KAL1842198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="1251"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="760"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1345"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1615"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1764"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1898"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1386"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1620"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1672"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1687"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1799"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1906"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1955"/>
            <end position="1968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1968" mass="216505" checksum="507BE2C556C1F024" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK30</accession>
    <name>A0ABR3VK30_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="27"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="479" mass="53405" checksum="F51B710357004A00" modified="2025-10-08" version="1">MNATSLAQALQAYRAAAPEKLAFLEPRGLVNTGNMCYMNSVLQVLIFCIPFYDFLDQVGKKAAHSFKSETPLVDAMVMFMREFKALETAASAEQLRKRIKPEVYEKYGEPFTPEFVYDAIRTLPRFASMRRGHQQDAQEFLGFLLEGLHDECARVISQAPASTASTAPNSSLPSPTIANVGEGADDWLEVGRRQRPAVTRSSGHSHTQTPITKIFGGQLRSELRVPGNKNSVTLEPYQPLQLDIGSPEVRNIIDALRGLTRPEVIHGDFDSPHGKDVRATKQVFIESVPPVLILHLKRFQFDAEGYGTVKIWKKVGYPLEFEFPREVLSRQTRNTMLSENSGAPRYRLIAVVYHHGKNASGGHYTVDVRRQDGREWIRIDDTVIRRVRDEHVAEAGAEEDAGKTDARKDVPGAASGNRFLGMNDEDTGDDDGWKQAAGGKKWSSVVNGATPTNGHKPKPQPKDSIKDNKVAYLLFYQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK35</accession>
    <name>A0ABR3VK35_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000065">
        <property type="protein sequence ID" value="KAL1841735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047404545" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="115"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="594" mass="63619" checksum="DFF548EA8328DF9C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK71</accession>
    <name>A0ABR3VK71_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant" evidence="7">
        <location>
            <begin position="105"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="299" mass="31919" checksum="224FB00F698A8116" modified="2025-10-08" version="1">MARRLLPLRPLACPPSALPSHSTASAASSLSTTAPPPPSRPWSSRARPASPSSLIRGLPLRDVSRFPLRHFCPINPMILLSPEMRTSKDVQGNAYTPLPSYHPGTQQACLFRDNHAFLTTENGISIYGLSTDSPKANTTFQTKQKLPYPLICDPQSALIGALGLKKAPGGRGSGTTRGVVVIDKSGKVLAAVAGGPKVTVDAVLEVVQLEEKKGEEANGEEKKEEEVVKEAETEEKKEEEEAKEEADKKEDEGADKAEKKADENGDVPMEDATAAKEGEGAAVANGDGEAKTEEEEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK98</accession>
    <name>A0ABR3VK98_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ergosterol biosynthetic protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_7173</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1841336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19463" checksum="7491B88B7A9C0BA0" modified="2025-10-08" version="1">MDNLLEYLPSAEKGYLPYYLFLVSIVAVGNSLQPYATLHYTRRIYNGLFVPNNALPPKTERFNPEDSTNKLKPASSTGKDAAKAVDQVTPLAGRLFGTYTFLAGIIRFYASYQLENPAMYQMALLTHVVAAVHFTSETLVFKTIRFSGPQAFPFLAAYSGTIWMLLQYNHYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKI3</accession>
    <name>A0ABR3VKI3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045909905" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="118" mass="12594" checksum="7DCE22ABAF307AE0" modified="2025-10-08" version="1">MQLTKALVLVSTLAVGILAAPAPAPAAEDGPPGAAPASVSESAGLGLAPSADERYPTPDICWFECREFFCWIPFVGCLPECVYACMTDRCPYFKYVVPFISSLFSYFVATRYGPTSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKI8</accession>
    <name>A0ABR3VKI8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitronate monooxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22874" checksum="87A3BEE02C2DE18D" modified="2025-10-08" version="1">MPFDTELTRRLGIRIPVVIIDEGIKVVETAGNSPGPVIAQLKAAGITVLHKCTTIRHAKAAVKLGADFLSIDGFECGGHVGEHDITNFILLSRARQELNVPFIASGGFADGQGLAAALCLGACGVNMGTRFLCTVEAPIHHNIKEQIVKAQETDTALVLRRWKNTTRLYRNKVTEQALKIERESKTGDFAEVAPYVSGKRGREVFINGDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKM9</accession>
    <name>A0ABR3VKM9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="135"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1012" mass="108371" checksum="8EF789A43DEBE303" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKY9</accession>
    <name>A0ABR3VKY9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="122" mass="13818" checksum="F2CF30AA3D691FEF" modified="2025-10-08" version="1">MSLPEQLSQASKSSLAVQYVDGHFVESYYPTIENTFSKEIRYKGQDFATEIVDTAGQDEYSILNSKHFIGIHGYMLVYSVSSRQSFEMVQVIRDKILNHLVRRPPLPHTSPSLPPLGTNQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKZ9</accession>
    <name>A0ABR3VKZ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047405123" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="18"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="157"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="550" mass="60380" checksum="E294E01CA2924A08" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL13</accession>
    <name>A0ABR3VL13_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="681" mass="75794" checksum="3100D0528FFC174D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLC9</accession>
    <name>A0ABR3VLC9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="465" mass="50612" checksum="0370B1FA6041A54A" modified="2025-10-08" version="1">MTRIQDARVDMYEALPVPFGLVRFGVAPDHPEVKNCQEKFEEVAASPNFTFIGNVSVGTASDHPDGAAVPLASILRHYNAVVFSYGAPKDRALGIPGETLPGVYSAREFVGWYNGLPEHADLAPDLARGGEAVIIGQGNVALDVARMLLEDVDVLRKSDIAEHAIETLAKSKVKRVHIIGRRGPMQAAFTIKEIRELMRLPSVGFHPIDTSLVPPDPKSLPRAPRRLMDVLLKGSPTPPSQAAKSWSLDFLLSPTAFLPSSPPSSQPRLSAIQFARTTLSSPFDPQAYALPTNETIELSTPLAFRSIGYRSAPLPEFSALGIPFSERHGVISNDGRGRVRHEERTRDAAMSLGTFPGLYCAGWVKRGPTGVIASTMEDAFSTADAIAEDWADERVRFLNEGSGQGLEEVNGWEGVRKEMTGGAEKKVVHWDGWKKIDAAERERGAKVGKEREKFTRTADMLAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLD7</accession>
    <name>A0ABR3VLD7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AT hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="76087" checksum="17DA7C3A9CFC5688" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLE5</accession>
    <name>A0ABR3VLE5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="278" mass="31681" checksum="E5084F5DBA7E452C" modified="2025-10-08" version="1">MAMRPSLFTRGLSGLSQSSDPNSPNVSSPAEQRDDAKRNFLKAMRPLPTQHYWHVWFDRPPPKDAQQQQSGTTAASNAEDYQSQLEQLPGRIESVQDFWRYNNNTPVDQIKMRESLYLFKAGFRPVWEDRRNVLGGSWTFRVPKSIGPDVWTRVQLLAIGEKLQSVLEEGDQICGVGLSVRFNSHLVSIWHRDASRQKSVDNLLQCVLEELPQELRPKPDNYFYKRHADHAGFKAPPELQAVIDSQRAREAAAKAAQEQKEKEVKEQQQQEEGGEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLF3</accession>
    <name>A0ABR3VLF3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="451" mass="49953" checksum="F22BE1B00150C622" modified="2025-10-08" version="1">MRLSAGYALFLAGIVRAESQYLVNELSFGHGPRIAPEGSRSIPNFSIQGSPYVPELLSNKVILTPVAPGNARGAVWSDKALQNQNWIADIEFRANGPERGGGNLNIWVVRDGSHAVGSNSLYSVGRFEGLALVVDQHSGSGGMLRGFLNDGTTDYKHTHNVDSLAFGHCKFSYRNLGRPTQIKLRHNESKFRVEVAGRLCFETDKIRIPSGYNIGITASSADNPDSFEVFKLAVLTTETHHDYSQQQHDSSGSSQGSGNAKPPTQQRMNFGRGGQAAIDDPYDNAIPDEDADKITSSKAQFADLHNRLQSVNHHLTTIFRTIAQNGQVDEQRHAETSALLAELKGLITGRLDKLEMLLNKLEKIDVLEQRMRDIEGEMRATRHEITGRLHDSTSAIKFHVEDKHEALAKRVREQTHSGHARLVWVVLGSQCLLVGAFAYYKRKKAHPKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLK9</accession>
    <name>A0ABR3VLK9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="8">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="7">
        <location>
            <begin position="393"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="922"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1056" mass="120685" checksum="7B0AEB3311DE39EE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM80</accession>
    <name>A0ABR3VM80_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="335"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="986"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1149"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1166"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1236" mass="135801" checksum="F98670C40ACC7131" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMF6</accession>
    <name>A0ABR3VMF6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="5">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="193" mass="21490" checksum="6AB00BCBA9A417F1" modified="2025-10-08" version="1">MNFPGGLLTWPCYVNATREAEAAKKAEQARKKAEREALLAEEEKSLPSRATPKNAKTATKKTRGLDLSQLDSLDSGSGKALPALNASGIDNALDALSLTDKSDATKVDRHPERRFKAAYAAFEERRLKEMDADGSGAGLRLNQKKERIKKEFERSPENPFNQLTVRYDASKEEIAELKEKERTKIENRLAAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMI5</accession>
    <name>A0ABR3VMI5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000027">
        <property type="protein sequence ID" value="KAL1842990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="88873" checksum="EB78E16914E4534A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMI9</accession>
    <name>A0ABR3VMI9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="675" mass="74410" checksum="1E8945AD708C90DD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMJ6</accession>
    <name>A0ABR3VMJ6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="519" mass="56377" checksum="2AF47993228F05FA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMT1</accession>
    <name>A0ABR3VMT1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000051">
        <property type="protein sequence ID" value="KAL1842191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="340" mass="36966" checksum="A4CB84BC6E724BCB" modified="2025-10-08" version="1">METDAQPSSVPPSIVVAASSSSTPSMPAAAAPEPRGGPTPSPLPCPAPASGPEDATSAGPADNNRTSSSSSSSSSDSESEHEPKPTIRHPKLLLKIQDLAHPGTAKFFRAVPDPGAVLAEAVDNIDRHLYCSPDGSQKPKKKFHAPPTRSVTLVLRDMDGVAYTTGSEIDNDHKEIHFSLRYIDHIRPESRLAAEIRGVLTHELVHCYQWDARRTCPGGLIEGVADWVRLCCDLGPPHWRRGTEGSWDKGYDHTAYFLQYLETRFGPGTVQAVNAKLRRHEYRGDAFWRELLGMPVEELYADYVKAVKGGEGDGKGIRIQNIGNDVLCTMCPSFCSSPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMT2</accession>
    <name>A0ABR3VMT2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="200"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="449" mass="49770" checksum="023CCBD9425B8174" modified="2025-10-08" version="1">MAEITITGWITRDVRFPTSLDKTGSDAMNVACDYSAAYCILQTDSTYTGHGMTFTIGRGNDIVCAAINHVADRIKGRTLSSLVAHWGKTWRHLVNDSQLRWIGPEKGVIHLALGAVVNAIWDLWAKVLGKPVWRVVADMTPEQVVDCIDFRYITDAVTPEEALAMLKDAEAGKAERIRDAENNRAVTAYTTSAGWLGYDEDKMRALLQETLAKGYRHFKLKVGGSVVDDRRRLAIARDVIGCDRGNVLMVDANQVWSVPEAIEHMKQLAEFKPWFIEEPTSPDDVLGHKAVRDALKPYGIGVATGEMCQNRVIFKQLLAAGAIDVCQIDACRLGGVNEVLAVLLMAKKFGVPVVPHSGGVGLPEYTQHLSTIDYVVVSGKRSLLEYVDHLHEHFVHPAVITEGFYQTPTEPGYSVEMKPESMDRYEYPGGEGSWWRTNEAMPILEGEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNW3</accession>
    <name>A0ABR3VNW3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_4020</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 22">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="18">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="17">
        <location>
            <begin position="332"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="498"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1842853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="603" mass="65957" checksum="BBE1B220475DAA38" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNY1</accession>
    <name>A0ABR3VNY1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000020">
        <property type="protein sequence ID" value="KAL1843274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07652">
        <property type="entry name" value="F-BAR_Rgd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04398">
        <property type="entry name" value="RhoGAP_fRGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF136">
        <property type="entry name" value="RHO GTPASE ACTIVATOR (RGD1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="490"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="686" mass="75048" checksum="B99B738AAE3EB978" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP85</accession>
    <name>A0ABR3VP85_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="414" mass="44984" checksum="B22D00EE24E5B063" modified="2025-10-08" version="1">MSEATSAPLDPALYESMAGVVIAVVSVCLTVAVTTVTLRTYTRAIVLRQFGADDWAAILAVMFAIGSGTMVALNTKYGHGQHLAVVDPTLLWKYFRTFYISIVLYNASLTATKLTFLLQYHRIFGNTAGMRKIILIAFVLVGLWSISQLLVVIFTCTPIHKFWLAETPGTCIPNLPFWYINAAGNIVTDIIVFCIPLPSVTRLKLRRGAKLGLIGVFCLGFFTCAISVIRIQYLRLSDDVTWDNVASSCWSIGELCSGITCACLPTLRPLISRMVPGMGSESGGSNTGPRKYYYGSSSGGRDASHNTSRHHKSNHDDTASARGIIYPEDVELQSDNGSDKDKDVRIEARAAAPSPSSLERATRPPTLDRARFGLGPKSTVHTEVGVATPGPESAWRAADGRIQVKTDFIITRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPD3</accession>
    <name>A0ABR3VPD3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="256" mass="27165" checksum="82B21AB6C5129DA0" modified="2025-10-08" version="1">MFSLEGHTALVTGATRGIGKSVAIALAEAGADILLVQRDPSSTSTQEAIQTLGRTATIYQADLSSPSSVSSLIPRILADGHQIRILVNCAGIQRRHPCERFPDSDFSEVLQVNLNSVFSLTRDVGAHMLGLDPHPVTGRRGSVINFASLLSFQGGFTVPAYAASKGAVAQLTKSFANEWTARGVTVNAIAPGYIETDMNEALLNDPERLASISQRIPAGRWGTPDDFKGTVVYLASRASAYVSGHVLVVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPE8</accession>
    <name>A0ABR3VPE8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF2">
        <property type="entry name" value="SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="340"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="45936" checksum="CF262F9C241A5660" modified="2025-10-08" version="1">MKRIRYVTNLLHSKGPGENAKAAMMLKDYDDCEGVLNQAACMSLVTTQLQLMTEYEHLYDPVLGPTDRPNRAAETSRLQLERIFKLKEAYRDLKDDILDELGKIDVQVIKPASSARDSLAPVRKTIKKRENKRLAYELAQERAITLEKKVFRAPKEDAALSKAEAERARTAEEFEAVDRHLREILPSLLRITFGLVGPLVETLVAIQHRLMALTYTTLHDYCKAVGFPATALSTQEIIEVWANQFGPVRRKVESIGCLGRNKTMQQNKAKKTGPSVSGVRGLNSMDGTPIDNLSAPVPLPAPRPSQRTEPAFSAPPPPNEKLPFQSTSPSKPGLARANVNSLTTATVLGGSSIAAGKKKPPPPPPPRRTAGQRTGDLSFLQGDRIRVIERTGTDQDWWTGEVNGVTGKFPANYCKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPF5</accession>
    <name>A0ABR3VPF5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="391" mass="44390" checksum="66969716C9E52B35" modified="2025-10-08" version="1">MFLRTASNTAARAAGARTWLPILVHGGATLRQQWFSTSPARRGNHIITFKPSSTPELDQLLDNYRHKVILPTYLSPEQRRRIYNPRQKQALINDPVTMEIDGVIHRFRYVDICQDLPSTTKTLSAAFKMMSTEDDFRNVRPLLEGARRAGRKLNNPLIGSLIRHAAEHDMLDVVLECAKAAEKTGIKLDRSEHISQLLAWIQWPAIRSGFPAEETKAALRRVCRVVDMLEEDEEVHRPEPATKGAFPFYRDPQVLAMRLHMAAARAVYHRKGKDDPEGNLGKWATELMALWPEDKGLLDLQPDEAYRDKNKMEYMLDRSQYLWVASPVLHGLTLAAQVVDPALAMQLQNRADKVEEEVKVAFASDKLSTKGRGRAMYNALFNRQEGEAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPZ1</accession>
    <name>A0ABR3VPZ1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="450" mass="49801" checksum="00F6D5E1AC6AD8BA" modified="2025-10-08" version="1">MASTNNVNNNNHQAPGTAPIGPAVPPNPGPAPGHAGPAQPNNNNSLVPVSHAQQAHSAGFRYFRSLPEELQIKIFTKLIEIPAPNFHKMIGKATQRVDDQGNRFFGVSFHPVTRSIDRSQYRELETFRGVNEESETAARLESNRRGQNNFLPFRRQGPKFSSANDLVIIQLPAKRHEASRFGYWNLFNQHLNTNGVLDCAALEESTRGMQHVALEFQPRDPSPRSVMSNWRCTARCPPPPQPVVVMGPGQPWPPQPLVPQPGLLPLQHQPVAMCPVEVNSFLLRFRDLRSFWVIVDPAAVARRSNFTIFVKNYLSLPEDCPLRRNLQVFHGRGLRYIEYEEFLVTEENGRVLGLLGPDVRRFKADLTVAAQLQRAQAVAQAVAAGKDAAGIAAATAAASWPRAIKIGVLIPVKEDRIEDWGAETAVRVASLLHRWEERNEGQGNAAGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRA7</accession>
    <name>A0ABR3VRA7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_4957</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="108"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1844105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="588" mass="67101" checksum="760B7058FA04C97A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRE5</accession>
    <name>A0ABR3VRE5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="556" mass="61467" checksum="A7EF9DE8806009BA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRM0</accession>
    <name>A0ABR3VRM0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1844263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="98" mass="11080" checksum="EF09956F3290AE21" modified="2025-10-08" version="1">MMRTSVTKLARPARPLSRMFSTTARAMSAGATGAPPKTGGQGDAFQRRERAQEDYAIRQREKEKLKELKKKIQEQQAHLKQLSDHIDEITRDQGGENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRP9</accession>
    <name>A0ABR3VRP9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_15</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1844336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="561" mass="61482" checksum="1145DD23DDE992E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRS9</accession>
    <name>A0ABR3VRS9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin reductase</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_42</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="4"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1844363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="326" mass="34901" checksum="3AB9AEBC4DCED599" modified="2025-10-08" version="1">MHSKVVIIGSGPAAHTAAIYLARAELKPVLYEGFMANGIAAGGQLTTTTEVENFPGFPEGVTGQELMEKMRAQSERFGTVIISETVAKLDLSKRPFEYATEWSPDEVHTADAVILATGASARRLGLPGEDKYWQNGISACAVCDGAVPIFRNKPLVVIGGGDSAAEEAMFLTKYGSHVTVLVRRDKLRASSIMAKRLLSNKKVTVRFNTVGVEVKGDEKGLMSHLVVRDVRTGQEETLEANGLFYAIGHDPATALVKGQLETDEDGYVLTKPGSTLTSVTGVFAAGDVQDKRYRQAITSAGTGCMAALDAEKYLAELEEEQADGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0W5</accession>
    <name>A0ABR3V0W5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000710">
        <property type="protein sequence ID" value="KAL1835359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF51">
        <property type="entry name" value="MYB-LIKE DNA-BINDING PROTEIN BAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="484" mass="51638" checksum="9F5658255B119EDE" modified="2025-10-08" version="1">MATKPPLVAAKRQSKWSAQEDRLIIELRQSGMKWDDISKHLPGRSAISCRLHYQNYLERRGDWDEERKNKLARLYERFKPEMWAKVAEELHVPWRAAEAMHWQLGEIEIARRAGVTPFSLSTTSHEPSAGHHRTTDSSPTHHAHGHQRSHSTSTRFTRDFPGGLPSPRYTRGAPPLPPPPTAPAPYHYHQFSPLATPTTSAPSSSSSYLPPRRESFAQPRTTPAAFGPPLLPEYGYGTASAGRSNSPGGGGSTGRLLPSVAEITTGSYHHHHHHHHSPYTSSPAHPGYGTLASDGAGSLRESDPKGADRESAAAAYHQLGPFRAPTTTTSRAGGPPLPSLHGPPPHTTAAGPGYGFPPLPPPPPPPPPPSSSSSSSSGSLSLSSSPPGMSTASRVPPPPPPPPPPPPGSTTTTTTTTGGGGGGQYPEWPLQGHEQQQYPPQPSGQQQYEGLTLSPAKRRASPPDGGREASRRRGLAGHGQRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1X7</accession>
    <name>A0ABR3V1X7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000690">
        <property type="protein sequence ID" value="KAL1835396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046932885" description="LysM domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="240" mass="26022" checksum="BA2C5E4688C9CDAE" modified="2025-10-08" version="1">MLISKLFGGLVLAATAYSRSIVRRACGFSVPAASGDTCASIAEFWGITEEDFIAWNPSVGPGCSLGVVPEQEYCIEWIEPTTSVTATPTTTSTTSSTTTITGPSPTQTGIIPTCTTFHKVVSGDTCQKIVDKYGTFTLSDFRWDGSAGNAPGPTQTGITPDCTTFYQVISGDTCQKIVDKHGTFTLDNFGRIRLFGAPGRRLRLRWSTRYPDNEANEYRPLTYADRADPFLQDFLPSRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V211</accession>
    <name>A0ABR3V211_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000542">
        <property type="protein sequence ID" value="KAL1835761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="454" mass="49858" checksum="FB4B6F6A9716683D" modified="2025-10-08" version="1">MAANNQMRQGCLQPGLNGPGPNPHQIISLRKRLVQETSDKAAKIGRVRKDVAIKLDEILPAAEAQVTVYDKLRDEIDTEREDIESKKANPGVGDWAPLAQRILRTGNTTLPRTRPARCGNTVNAPVVDHAVHEAINALCLSHDTSPTIISCRLAMDQVARILQSRWPAIEWPFDHKRRITHQASLSRTATVTDGDTATPDAEAVDTETLERVELGQMALASDPGLGVVYIFYCENRSILVADKRRCRWKGASTPYVEAPPGHQDLVFNIEEAGPGGIWCLQNWAQKMPWITKTQKHHESSPESRGASRRESSPGPRGVCAVNQLPDPLAPYASIPMFSGFQLEFIQALEIGVSHWGLTSLFPGLVAELLKVDLDRLAGLLGSVGSLSTPRDIFQIFHRIKRDVVASVVLGTVAFDTHESRSHGERLRGVSSDGAGIYILMPARQFRPSGHIHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2N8</accession>
    <name>A0ABR3V2N8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000488">
        <property type="protein sequence ID" value="KAL1835985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="230"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="833" mass="92513" checksum="E2FEB0BB2A7334D4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V343</accession>
    <name>A0ABR3V343_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000449">
        <property type="protein sequence ID" value="KAL1836194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045752638" description="glycerophosphodiester phosphodiesterase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="72"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="420" mass="45839" checksum="A5ED7708615B6ED4" modified="2025-10-08" version="1">MSAIRLLICAALVTSGLAVPSAHGKHHHDGLVKPVKRVSLGPRPFWLVDDMDDGPLKRKLASCADMEMKPSAWSISHRGGGTLQFPEHTYESIMAGTRMGAGIQECDVTFTKDRQLVCRHAQCDLHSTTNVVAIPELNAKCTVPFKPAANGSEATAKCCTSDFTLAEIKTLCAKMDAYNPEATTPEAYLGGTPAYQTDLYAKTCSPVLTLREFIKLVDDLGLKFTPELKTPEVPMPFPPGSDYTQARFAQQMIDEFKKAGIKPERVFPQSFLYDDILYWLEAEPRWAKQAVLLDESGDAPGAMPQAIANLQKYAKAGVKIIAPPLPYLVTAKDGKIVPSEYAIAAKKARLKIITWTLERSGWLGDGSGGGYYYSSVANITNNEGDVFNLLHVLAQDVGVIGVFSDWSATVTYYANCFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V355</accession>
    <name>A0ABR3V355_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aip3p/Bud6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000456">
        <property type="protein sequence ID" value="KAL1836154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aip3p/Bud6 N-terminal" evidence="2">
        <location>
            <begin position="90"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="303" mass="32202" checksum="C87D31DFB1086B10" modified="2025-10-08" version="1">MNSTRSSQRRSPGADPGPPPSVPPRSMSPAVGVGTNRPVAPRSSAPSASSRAMQQATGSGVVTSGSRNDSTRRANSSGGSSSSVPLSQIEKSVTHLLVATKQLLETLTQWSKGNATDTQVSDVYVRLGYEFNMACRAFSAINVDTSDLGNVPELLRNILEATLSQEASPESLERYLPKIRDIIINLLHGLKRKQTRLRQKQQRERDTGSGDSVAGGSPPPVPTRTTSTSTMSSANTGLTTLLNEGLDGGGYRPDSMREDSRASAVSSPTKRYVVPRDPSRGSMNSDPSTLSSNTMQNMPVRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3E6</accession>
    <name>A0ABR3V3E6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000432">
        <property type="protein sequence ID" value="KAL1836299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="41"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="307" mass="33640" checksum="8388659D9C9D2C4E" modified="2025-10-08" version="1">MSASWMWGPAPPGVDLTENQNSDIIGAVVAIMIIGLSAVVLRIFSRLSHSGPGLAEDDYVILVAAVLGIGTAVCCLVSVRWGGGKHLWVVTADEFNKLYQTTYAFVIVYIACISATKTSILLSYRRVFGDGIIWYIVFTLTLCHWAEVTITWLSGCRPVSYYWRQYTDPTAVGTCIDAPLFYFINGIIGLFIDVAILLVPIPTLIKLQMPPTKKIFIGGIFLLGGFVCVASAVRIVMMDQLVKSPDFTWAMSKVFIWSCVEPFIGIVCACLPTYAPLVRKFWTAAATHHSRARFAVGAIAPRACLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V447</accession>
    <name>A0ABR3V447_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000423">
        <property type="protein sequence ID" value="KAL1836357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="569" mass="64602" checksum="A76EAE55C9DFB55A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4T0</accession>
    <name>A0ABR3V4T0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000374">
        <property type="protein sequence ID" value="KAL1836721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1836721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="104" mass="11668" checksum="F8C7A714EAE18D31" modified="2025-10-08" version="1">MSLHGTQQNWDDDDPSFEGSARALTTLVSRNVQYYCTLYRRPGAVPRFAAEARFDGPASLPFTAVDSEVRNTTPSFYQRSRLLTDNSSKTVTPEQSVEMFPQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V589</accession>
    <name>A0ABR3V589_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SMC hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_4500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000349">
        <property type="protein sequence ID" value="KAL1836923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="9">
        <location>
            <begin position="795"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1228"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1276"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="516"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="674"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="948"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1236"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1249"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1600" mass="176796" checksum="84A7841D103C5E0A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5N0</accession>
    <name>A0ABR3V5N0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000334">
        <property type="protein sequence ID" value="KAL1837058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="96832" checksum="2A6DB998BE966E41" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5R2</accession>
    <name>A0ABR3V5R2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000331">
        <property type="protein sequence ID" value="KAL1837090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="65"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="352" mass="39161" checksum="8E2C83AB335E26CE" modified="2025-10-08" version="1">MASYQNNFGPGNYGLQVGQNESIKVDIHQQQIHLPPESSRPRPSAFIPFSGDPDFVNRGDILDRIAKLSSKPQSHTRVALVGFGGVGKSQLAIEYARRVDAAEKEKPDEYRKWIFWMHAGTRDRVEQGFRAIAKDVELPGREDPQANIPQLVHDWLLDERNGAWMIVIDSADDYDVFCAKPSDDSEPLAHYLPQSHNGSILITTRNMRLARELTGSHKYTIEVGPMAQSEAVTLLQNKLEPPPDPETADKLVEALGFVPLAISQAAAYIQKRTPLYSAQQYLADFPPKMSELLHHDAGDLRRDPSASNAILTTWQITFDHIQDERPSAADLLSLMSFFNPQGISKAVAVGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5W2</accession>
    <name>A0ABR3V5W2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_4217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000325">
        <property type="protein sequence ID" value="KAL1837133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF11">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="466" mass="52352" checksum="4D0925850DD57756" modified="2025-10-08" version="1">MPFWNREFPDLKLHDASERERLVTTSQPRGFRIGTGASIFIDSLIPAILSARHEVILVTCFWAPSKTLKALHDALTELASRRRELIQDTVARRDSPIPPLRIRICFSSRSLLQKLFHTQSRHGYIYPPSTWSKKLGLPDPKVLEAGGIQLQVKSLFFLPFSVMHPKFVIVDRRRAFVPSCNISWEAWLEACVELTGNAVQELLSFYSRTWEDAHDILGTDHEENEGSERVDLGGPTDPPPSDAHHHATFRFHNPVPTLVLPSPSHRNPRFHPFPWQKGPRPPGTPLNVAVLQLLEQAERSIYIQTPNITCEPVIVALLDALARGVHVTVVTNKNMMLLEQLVTAGTTTSWCVRSFVRRFKKLASRGGGQADPAQDVEVANRTGHLRISYFRGRATEAQHLMDGHCEEPVHSHLKLTVVDGTFAVLGSGNMDRASWYTSQELGMMFCSREFCDSIKAGLDMALRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V696</accession>
    <name>A0ABR3V696_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000330">
        <property type="protein sequence ID" value="KAL1837092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="314"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="777" mass="87668" checksum="AF38A63E6D310D95" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6D0</accession>
    <name>A0ABR3V6D0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000307">
        <property type="protein sequence ID" value="KAL1837323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="20"/>
        </location>
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            <end position="334"/>
        </location>
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        </location>
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            <end position="1055"/>
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        <location>
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        <location>
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            <end position="953"/>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1837323.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="entry name" value="PROTEIN CHIFFON"/>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000303">
        <property type="protein sequence ID" value="KAL1837354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="47"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="265"/>
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        <location>
            <begin position="47"/>
            <end position="58"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="315" mass="34616" checksum="FF29446A260A451A" modified="2025-10-08" version="1">MAPLVSPEAAPDPRRVASVLRELQSTSSPDDYTILKLSEPITSAAATAYKNNDGTGNPTPAPRTSDVSTSSLDTGPTPSSLDADLQHYRELFAKLRFSYVEQVTKEKFIRAIVGDPPVIVSAQEIAELEGSNAEAKTALKQKKEEVEALIKELEGRGKGVVERYEKVRQGLKELEGLPEEVERLEREVAALRETQRKRMEVLGLGGSGSGEGGEMALPLGKTRELVEERRAKLVALERQLEAVNRQVPSKKKELERIKAEVAALEKKRTHSTAAAREAKRRKEGAQAGGEDELEARGRWYRASEAVLREVLDLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6J0</accession>
    <name>A0ABR3V6J0_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000303">
        <property type="protein sequence ID" value="KAL1837350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="194"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="379"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="669" mass="70443" checksum="D3960DCD8519D885" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6W6</accession>
    <name>A0ABR3V6W6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_3686</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000286">
        <property type="protein sequence ID" value="KAL1837519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1837519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="315" mass="34104" checksum="3D10ACEC5077B892" modified="2025-10-08" version="1">MSKKQEQTIMGMPPFVVDFLMGGVSAAVSKTAAAPIERIKLLVQNQDEMIKAGRLDRRYNGIVDCFRRTTADEGLMALWRGNTANVIRYFPTQALNFAFRDKFKAMFGYKKDKDGYAKWMAGNLASGGAAGATSLLFVYSLDYARTRLANDAKSAKSGGARQFNGLIDVYRKTIASDGIVGLYRGFGPSVAGIIVYRGLYFGMYDSIKPVVLTGTLQNNFLASFLLGWCVTTGAGIASYPLDTVRRRMMMTSGEAVKYKSSFDAFSQIVAKEGVKSLFKGAGANILRGVAGAGVLSIYDQLQILLFGKAFKGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V769</accession>
    <name>A0ABR3V769_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000277">
        <property type="protein sequence ID" value="KAL1837624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="52"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1837624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="555" mass="61383" checksum="0925101213514569" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V792</accession>
    <name>A0ABR3V792_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000275">
        <property type="protein sequence ID" value="KAL1837654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="320" mass="35129" checksum="24C99686FF83A8A1" modified="2025-10-08" version="1">MPPNRILRGFAPLVNNSARPARPSTSIRLPAQPTVSLRHAHTRSSPSTPLLQPARPQRHHGRPQPWAHLLPRTSRRTIFIQTEPTPNPDALKFLPNHRVLPEGVTAPFVEYLNPRSTIAPPYPSPLASRLMSVDGVTAVFYGADFITVTKAADANWAHIRPEVFSLITEAITSGQPLVNVSTSAAVERKDETAAAAGGEEAATPETDSLAYDENDSEVVGMIKELLETRVRPAIQEDGGDIEFRGFEDGYVMLKLRGACRTCDSSTVTLKNGIEGMLMHYIEEVKGVHQVLDQEEEIALKEFAKFEEKLKAQKNSEANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7A8</accession>
    <name>A0ABR3V7A8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">VTJ49DRAFT_3555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000276">
        <property type="protein sequence ID" value="KAL1837635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="218"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="298" mass="32936" checksum="979639C8CE6D6224" modified="2025-10-08" version="1">MAPPTKHDWADDDELEETTTTTDLPPPQKIQNKDGTWTIIEYRYNDAGQKVKATRRVRYVVRREVVNPRVAERKTWTKFGDSASDPPGPVLDTTTVGENIIFRPSVNWRREAKDEANDPNAQAMKDKLKDKKVKCRICDGEHFTARCPYKDTMAPIGEAGAAADVAAGLDEVRGAAAAAGAAGPGKKGSYVPPALRDRANAGAGERMGGKYGERDDLATLRVTNVSEMAEEHELRELFERFGRVTRVFLAKDRDTGLAKGFAFISYADRDDAAKACAKMDGFGFRHLILRVEFSKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7D2</accession>
    <name>A0ABR3V7D2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000270">
        <property type="protein sequence ID" value="KAL1837699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="368"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="518" mass="57529" checksum="C87DC9DA5DA06970" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7G4</accession>
    <name>A0ABR3V7G4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000302">
        <property type="protein sequence ID" value="KAL1837361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CorA-like transporter" evidence="1">
        <location>
            <begin position="15"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="255" mass="29594" checksum="EF58B08CE53D8E1B" modified="2025-10-08" version="1">MVLEPDLFRSHPLTEFYERGFRDVDELEHHLVDSQDIRTRHVFIKSNFSKRKLMCSRRLLECVMRHEKIPAAFLRRLSAFSAERSQYGPFVDSGLVGFQARHEGSMLRCWYVLPTPQRRWAMGSDGDPAPWLWTTDVMVVYHSFDLNNGKSFFLSFTGDMDGLLMRAKSPALWAPQAPFHVDGLSLVRNKMKTALSTQLLYLFWANSQWRKVVRSARDSEVANPFRASDLHRVADNYYDHPGSTRLNERATHANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7L8</accession>
    <name>A0ABR3V7L8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxalase/fosfomycin resistance/dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000263">
        <property type="protein sequence ID" value="KAL1837789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase/fosfomycin resistance/dioxygenase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="146" mass="15388" checksum="6CC91462F6087481" modified="2025-10-08" version="1">MTISHTGIRGPPALHNTMVQWYEAALAPLGYKRAMDFLDGLVVGFADNDSGEADWWVSSADASSPGSQPASEGEEDKTVAKIVGTHTAFVAKDRTAVQAFHKAAIEAGGKCNGPPGVREMYGPSYYAAFVLDPAGNNIEAVCLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7W5</accession>
    <name>A0ABR3V7W5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000267">
        <property type="protein sequence ID" value="KAL1837730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="275" mass="28786" checksum="CCD74FF0132292FC" modified="2025-10-08" version="1">MPNFDPSISNGTCYRASDDLSADIFIPCGNSAFGHISCCQAGDKCLEHGACYNNHYRTTYLAGCTDPLYKDASCPDKKSYKAGDRIPDVGWLPTELGGRINWLAGHGPTATVPTSATSMPTSTTLSSASSEVTNITQDPQQQLSNQGLSDSQIAGIGIGAAAGALLLFGALCGLWIVCRRRRNGKDTTASQEPEEAAVQDPAINKPSGARPAEIPGTLETQSPVELPVPPVNTMPENHSHGAPAGHSHGSWLATPPPVSPMSASWKAFSSIPAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Y8</accession>
    <name>A0ABR3V7Y8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000273">
        <property type="protein sequence ID" value="KAL1837677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046932893" description="GH18 domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="52"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="436" mass="47981" checksum="63314943AF9AACD8" modified="2025-10-08" version="1">MKSARILLLAIAISSSSFIITSVSARSLHGPKPWSTTIPPTANPDPSSSEIPRLILYHQTTHTPSGRPISLLPLLHRRNHTIALTHLILAAWHIHPPPPGTHRYPCTIRLNDHPPDHPRYATLWEEVRLLQRAGVKVMAMVGGAARGSFSYDTLDAPPLPSSSPFSDREGTTGGRKGGYEEGWLFERAYAPLREAIIRFGLDGVDLDIEERMSQGGVTRLIGSLRRDFGPGWRSGKKGMKKGFVLSMAPVATALLPGEQGRHNLGGFDYSRLVKEVGSEAVDFYNAQFYNGFGSARTTRLFDRLVTTGGTVAALQRRHGQIGGIAGWEYFNGVPGGEDEPWRWAEAVSAVLRPGQSEPRLRISRVVVGRLREAWMVSAATAKGLVRAEGKGARGRWTVTLEHRDEDGDLREWLEPDVDYMALMNVDGEEDGVEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V845</accession>
    <name>A0ABR3V845_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MCM7</name>
        <name evidence="10" type="ORF">VTJ49DRAFT_3254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000251">
        <property type="protein sequence ID" value="KAL1837934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="9">
        <location>
            <begin position="393"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1837934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="472" mass="52795" checksum="97C4761D62134BC1" modified="2025-10-08" version="1">MALLQMKSPVDYEVQLTAFQNFLSDFKASAQDTITTVLGNINLDDFSDDDDFMDEDGANAPRRSQRAAKQKEAPRHKYKDMLQQLADRKISQVVIDLDDLAAYEKDLNEGLRLTEWVEQNTKHYVEILSRAVDKLLPPPSEDITFKDDVLDVLMANRAQRNQMLAEVADRDSDPTLLQDQYPAQLTRRYTLVFKPRSTGPNGVPIKTLSVRQVRGEHLGKLITIRGIATRVSDVKPIVQVSAYTCDRCGSEIFQPVTDKQYGPLTICPSRDCQENQTKGQLYPSSRASKFLPFQEVKIQELAEQVPIGQIPRTLTVLCYGSLVRQVSPGDVVDIAGIFLPTPYTGFQAMRAGLLTDTYLEAHHVIQHKRAYEDIEIDTTMARRIAKFTQSGNQYEYLAKSIAPEIYGHLDVKKALLLLLVGGVTKEVGDGMRIRGDINICLMGDPGVAKSQLLKYISKVAPRGVYTSGRDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8N5</accession>
    <name>A0ABR3V8N5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000294">
        <property type="protein sequence ID" value="KAL1837438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="51"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="218" mass="22954" checksum="A20820B5428936C2" modified="2025-10-08" version="1">MADRGGHRGRGRGGRGGPGGGRGGHQHHHQQQQHGAGGQGQGQGQEKPKKENILDLKKYMDKRITAKFNGGREATGVLKGYDALMNLVLDDVEETLRDEEGNEVTRPLGLVVVRGTLLVMLSPVDGSEVIANPFQQAQTEAQAQAQAQTEHEAEAQVEAPAAEAEGEAEAQTEGAAAEAEAAAMQAQQAYFQALQEELQAELEAYAAGRGGGGVLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8P7</accession>
    <name>A0ABR3V8P7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polysaccharide lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000236">
        <property type="protein sequence ID" value="KAL1838129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
        <property type="entry name" value="Polysacc_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046932889" description="Polysaccharide lyase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28264" checksum="4DFFEE082F88A274" modified="2025-10-08" version="1">MTVSALLVTLAALAFTNAGVIFQNEGTIEGWSATQVEHKGYLRQVDNVYFDKPPALAMGQVFDPNYPGRYHSELRYNAGYGLGDTRYYGFAFQLHPEWNFSPPISYNLAQFISPFPKCDSYMPTTMVWLRGSKLFTRTKFGSVCDQKLDTFSLDVEVTAGEWHTIIIGASWQANTTGFLQLWFDGKPVLDKQDIPTTVAETEQFQFRVGLYANGWYDDKSQRPLDGTYEVFYDKIAIATTKDEADPGKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8Q2</accession>
    <name>A0ABR3V8Q2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000239">
        <property type="protein sequence ID" value="KAL1838087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25280" checksum="C035E29E5FBA4D50" modified="2025-10-08" version="1">MQDGPRLPPEIWRVVAQALKPGNRNNAQDLFLFARVCMGFATLALPELYSVHHMGFSFMPSRWHSVVASTLGTTLFPYYLWITELDLSNLEYFVRKLRPGSPFFSRPLEKLEIRNWEVDLDCPAIVNEIVNLLTNPIRRAADDEMRQGSLAVLKTGHFPLPPSRLATWVSGFPRLVHLQALNVAELDGIVGSAIRANCPAFTDVLILLRHFEQPMWIASTRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8S1</accession>
    <name>A0ABR3V8S1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyl hydrolase family 30 beta sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000238">
        <property type="protein sequence ID" value="KAL1838102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047443824" description="Glycosyl hydrolase family 30 beta sandwich domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="5">
        <location>
            <begin position="35"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="387"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="52013" checksum="B1A44D3D28DF1B77" modified="2025-10-08" version="1">MTMHKVLAALLCAGSAAATPAEPPSPVQPRQAATTLSVDLSRTFQVMDGFGTSEAFQRAVQMSRLPPAEQRKALDLLFSTTNGAGLSILRNGIGSSPDMRNDWMVSIAPKSPGSPDRPLIYEWDGSDNKQLWVSQEAVHTYGVKTIYADAWSAPGYMKTNGQDSNGGNLCGLSGVPRCATGDWRQAYADYLTKYVEFYQQSNVTITHLGFTNEPDLTTSYASMRWTGAQAAEFIRILHPTLQRSNLTHKPLITCCDAGGWQQQAGMLPSLAPVNNMLGVVTAHAYMSQPNFALNTPHRVWQTEAADLQGAWTSAWYQWGGAGEGFTWANHVYQAVVNANASAYLYWVGVQTGSTNSHMVHIAGNFERVEPSMRLWALGMWSRFVRPGAVRVGISGESWGLRTAAFRNVDGSVAVVVINSGGNARVAARVGNLAGGKTPVSGRAWVTDNSRAIVEVTTSFVNGVASVDVPSRSMVTVVLYPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V962</accession>
    <name>A0ABR3V962_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000219">
        <property type="protein sequence ID" value="KAL1838365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1744" mass="194341" checksum="6E9F332995BE4CFA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V999</accession>
    <name>A0ABR3V999_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000236">
        <property type="protein sequence ID" value="KAL1838127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="538" mass="60548" checksum="2D5482B897E4C0D1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9A0</accession>
    <name>A0ABR3V9A0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000219">
        <property type="protein sequence ID" value="KAL1838362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30051" checksum="D53B8FCA6C1E1604" modified="2025-10-08" version="1">MSQLPFSPFLRAWYKWKMLRLPWRRKFLIGFDLNGNTYWEFLDRGAPRPPPPNLPSSSPQSRTRPIPTALRWRRIVRYPRGTHHDAVAVPPAWHQWLRHTRPDPPSLEEQRAEVARQARIKLLAAEADRRWEAKPRVMEDVTTATTAARLGVGAGQGKRTGTGTATAAAAEGVEDSAAPPAASTESTTPPPTGDKADDVAIRDRAGVEMREETWRRMQKQEQEAAAQAQKETKKSAAAQPNPWEQARRGPGEAWQPQAWEPKVKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9E5</accession>
    <name>A0ABR3V9E5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000217">
        <property type="protein sequence ID" value="KAL1838393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="240"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="360"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="57028" checksum="9232B9B165E6C4B0" modified="2025-10-08" version="1">MELAPPPVPVNIPVETQLLIGCCYEADQAEIVSRSLDQLRTALPESFHGHLIALAEEIRSSARLLRSLADRSQMHITRVPFMTGYLNVVLPCLSRSLKDIKGYYEDKTVSREMRWRRMYNKMTDEAGGLPLPQRFVLYNHFLVLLKQLLTRVRSPNFDLNALETLRTRIVRLREQRGLPPPAAQPGTLVRQNLMQLALVQDPNAHWAEQIFTLPLPSRTGLKHLKASRAFGPFQPWGHLTIPQDSKVLFRRTFDNDAISILVFLSSVDQCPYFLIRAIQNNTPWYSMFGAHELVIEREGSALQLKRWSKTDQCSKLWAVLYFLTWEEMVLFYCTFVALKARNLLTLQVHPHEFQLRREKRLFQAQIIDDSYKHSLIVYEDMQTRGLRLHAAVWEGELRQCPVWTAFVTHQSQSPTWLSRRSRHRVWLKDVQLYVFCNTYRQENMRQNKLGAFEVRFEREEAAKRFKELFLSRLGESESSSENEAVEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9K1</accession>
    <name>A0ABR3V9K1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000238">
        <property type="protein sequence ID" value="KAL1838106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="146" mass="14637" checksum="38C5440E98C1D215" modified="2025-10-08" version="1">MASYIIYPPVMTVTNPVVVPQMTTYAASQAPPPLAPPPNPPCPDTAGTPPGTTSTTTAAICFNRNGFNVSVPVQQQTVTTTTYTTTAAAAATVPTMATAMVCSAPVQQLAAPPPPPPPPPAAAAVVVGMPAVQQVVGLGLPLRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9R9</accession>
    <name>A0ABR3V9R9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000206">
        <property type="protein sequence ID" value="KAL1838584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="428" mass="46431" checksum="06EA07A1E8CEA965" modified="2025-10-08" version="1">MATEDARYRQTSQYQLWSFSPGQLAAMRETTNAAARARIAERLSYSQPPSAAASSANTPDPSGSTPAPGPALPEFLTPAEEAQLVAFFTSELLRAGDHAEMSDEIKATAAVFFRRFYVTNSIMTYPPQDMLIVALFFGCKAEGSFVSISEFGRTFGKEHPEEILAGEFLLCQGLRFALDVKHPFRALRGAIMELATLPDIDPARLGAAETRAREILRFSPFITDAYFHFTPSQIMLAALSLADRGLAERFITKTFHYVAPADNNSSGAGTPVADSGGGGSNTPSLSTKKGRANEDNKAEISGCQVRDKVLGAIEACRDMLSRELPERREHWTNKAVIKTQIAPLRKKLKACRDPDRWNLVELQRRRREQAARHADSEDEDGGRPGKGSLEADGAVFGEPLGAAKRRKVEGGKDGKGGGGLGDPFGPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA11</accession>
    <name>A0ABR3VA11_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_2842</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000225">
        <property type="protein sequence ID" value="KAL1838271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="11"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1838271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="613" mass="66969" checksum="150290D39183B418" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA33</accession>
    <name>A0ABR3VA33_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000198">
        <property type="protein sequence ID" value="KAL1838694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="74" mass="8321" checksum="9094F4E7F3749E1E" modified="2025-10-08" version="1">MARKAKSRVINVRLLSMAMTGYFYTFTRLRTAPPMSMIKYDPIDNTYINHALNMISSCSCVRILSSHLASTMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAA2</accession>
    <name>A0ABR3VAA2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000194">
        <property type="protein sequence ID" value="KAL1838764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF21">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM20" evidence="11">
        <location>
            <begin position="277"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="811" mass="89041" checksum="1E620A498E2B2371" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAF5</accession>
    <name>A0ABR3VAF5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000208">
        <property type="protein sequence ID" value="KAL1838532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047364920" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="163" mass="18379" checksum="838A3B917D0F7445" modified="2025-10-08" version="1">MFYVSPMLALAAMTSFAAAAVTQFCRYPDGFAIQNFTTFTPKGENEPTNIKFHYIDEITHLDVDCVYNGTQPNINADGELPRYLCDFKYVHFTCYAQKGNLTVFERLCYLEDQEEMHYDAIGWVKPKLDCCKSTNPEGVHCVANPDVVGAFFTGKAESPKVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAK4</accession>
    <name>A0ABR3VAK4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_2257</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="JAZGSY010000195">
        <property type="protein sequence ID" value="KAL1838759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="98"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="412"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1838759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="572" mass="64745" checksum="0F91C1122487C2CE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAR7</accession>
    <name>A0ABR3VAR7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_2060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000185">
        <property type="protein sequence ID" value="KAL1838929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1838929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="214" mass="23315" checksum="5F8020BF6B4B2672" modified="2025-10-08" version="1">MEPWPEPPMPDTPANLREFKDVNEGRCRLAAIRAQRLAGRIRLGLPVFSPAEVSLFARSPSAAGASAHLMHSLLWRLAGSLSDLTNLSQRLGDALQNANAIAIKLAKQINTSIRRFEEKLEAAEDPLMAMVTAVAKRARTGEPLEGEVNESALMGWSNALGISIGRFETLTEVTRRPTAVEQEAHLDNPSSTRLVLMTPLMGMFAGPLLPLTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAV7</accession>
    <name>A0ABR3VAV7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000182">
        <property type="protein sequence ID" value="KAL1838974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="345" mass="37002" checksum="7C7B555822C203DC" modified="2025-10-08" version="1">MDYDPMIMDDAEALGPVVKISQADSVRVKWELSNTDISFANSLRRVMLAEIPTIAIDLVEIEENSSVLADEFIAHRLGLIPLNAEGIDSLLYSRDCDCDGCCEHCSVRLILHAKCTGDENMHVFARDLVPTGDRINQVLGTPIINDSEGLGPLILKLRPGQEIKLECIAKKGIAKEHAKWAPSAAIGFEYDPHNKLHHLDLWYESDPKAEWPPSEYAAWEEPPQEGEPFDYDAVPNRFYFNVETAGPLPPDVIISEGIKVLQQKLAGLIHELADEGGDGGVNGDGYNGGGPRSPEYGAGAGMDGFNGGYTTPFGGAAAGNQSAWGGAGGATAYGTTPYGAGSSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBC1</accession>
    <name>A0ABR3VBC1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glucan 1,3-beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_2655</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000213">
        <property type="protein sequence ID" value="KAL1838458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045439052" description="Glucan 1,3-beta-glucosidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="979"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="10">
        <location>
            <begin position="54"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="10">
        <location>
            <begin position="412"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="11">
        <location>
            <begin position="1191"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="9">
        <location>
            <begin position="1244"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="763"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1390" mass="151091" checksum="2111E51081377F48" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBG2</accession>
    <name>A0ABR3VBG2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045201980" evidence="1">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="182" mass="20090" checksum="3803B2F6B1B45408" modified="2025-10-08" version="1">MKPVLMAAALVGTALSSPVAQADDPISTPSPTILQPGAYWIRAVVPPNYRKYLQTKPPNVPGKALLESHTTAGQFNIEDGQLVNKVSSPPLYMWVEEPADKQNPPRTLATWFNTTKNPFGTFGWQGDTLVWSVPSIQRQNTAAWLVCQNQELFINTGAYGWQTPTGCADQTIHYYNDRTANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBG4</accession>
    <name>A0ABR3VBG4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_2263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000196">
        <property type="protein sequence ID" value="KAL1838726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1838726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="166" mass="18549" checksum="B271A6266BE713BD" modified="2025-10-08" version="1">MSSNSTIQPRFSPGSDPESLQPALTPLLTSNGGRWTLARDGEALERELRFKTFARTWDFMTAVALQCKLKNHHPEWCNTFNTTFIRWTTHHPRGLSAKDVELAAICDQLAREFGEVEPDQQQQQQQQQQSQESQQQQGETTMSGLADRAAGSAGDCCVPKKGAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBG5</accession>
    <name>A0ABR3VBG5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000171">
        <property type="protein sequence ID" value="KAL1839184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="283" mass="31654" checksum="0B317DB80FF7F5BB" modified="2025-10-08" version="1">MSDSVSTSTASSLGKPEPPSTSYALPPTYATLSFHKADTLRLLNFPSDLVSAFEPLIIATWPPGIERQYSSGQAYEYKLKGRPFGTFRAQQLVGGIHLMRAAFALLRRHGWDLVFPVVCSTRYTAKDTLVFRRSPSPLPEVELLALAPQGTHRLRVIYDRAEGSNRDHREHLASLNAAVQETLEQLDYLKEGSWSHDTLEFVLKGRPWAPRLGESVKVRVLLLRLLATMEEHGWRPYASLVQRTGWDDFRMLDTWYFVREVAGGVVSAPSQGRAGVEAETGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBR4</accession>
    <name>A0ABR3VBR4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000167">
        <property type="protein sequence ID" value="KAL1839255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="600" mass="67387" checksum="A130F72DEB7CCADE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBV8</accession>
    <name>A0ABR3VBV8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000182">
        <property type="protein sequence ID" value="KAL1838982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="158"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="361" mass="40577" checksum="B9CDDA01F779F456" modified="2025-10-08" version="1">MEATQSAAAEPATLSHPDAAYPDDEDTVEITIKFPPEKHNHTWSFTPTDTFEDLIQALSFQFPNYDWSKAKALPDKRPAGRTLKPLYTPAADSSLPLSTLHLTTLRILAPQTTALTTLQAQRDAAIAWKTRRQQMRAHQARHATRPKPTTSSPQISTLSSADSDYTFQSLRPLPHLPNSQHALTLLRRLASDPGIRSVMRQHRFRVGLLTEMDPASHTSASHEGVTRILGLNRNKGQVIELRLRTDAYDGWRDYRGVRRTLCHELTHNVYSEHDGDFWRLCRQLEREVERADYWGSAGRTVGGEAEYYQPPEGSEREQDEEGMVEDHGGWFGGTAAEMRARADRPAQQDDGGSGNSKEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBZ5</accession>
    <name>A0ABR3VBZ5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000167">
        <property type="protein sequence ID" value="KAL1839256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1839256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="323" mass="33933" checksum="EC9CC91A3A5996AA" modified="2025-10-08" version="1">MTSNTMDPITPTIDLTGLRCKSILITGGASGMGLATARAWSAAGAFVTIADIQPLSVGEPLARSFGANYVWCDVTSWDSQVTAFKAAITSSPSRTLDVVVTFAGIAVAPGNQVDLVVAGGQPSLDANPPRPDTRNIDINLVGTYYSSWLALYYFRLPPTQPHPTTASPSAPATSGSSTDKSLVLVSSIAAYMDAPLASTYTASKAGVRGLFRSMRSRTAEIGVRCNLLAPWFVDTPLLNPTREALAAAVGESGDLGKAVAGFADVEVVVAAAGYCAVEKGVHGKAFVVQPEGIFDLMDDYEHGWAGDQMRPIMAMRKQAGYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCE2</accession>
    <name>A0ABR3VCE2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_1920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000178">
        <property type="protein sequence ID" value="KAL1839056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="142"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="14">
        <location>
            <begin position="487"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1839056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="581" mass="62813" checksum="2F22CE4448BFBE01" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDH0</accession>
    <name>A0ABR3VDH0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000150">
        <property type="protein sequence ID" value="KAL1839567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="122"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="423" mass="47001" checksum="C987465265C19331" modified="2025-10-08" version="1">MDWFGRANIAFTHSSSPLALRRKDGTSTDLVEVCKASTPACQLNPLLFNGNIQTMWTAFKEHGPPIHYRRRIFNADHATYTGTFAVDFAVPPHDDTDASLPPRTAYFSEEDFDKIGSDDDKPMLIVLHGLSGGSHEVYLRHAIAPLVLNGGNWEVCVVNARGCANSKVTSGVLFNARATWDVRQVVNWARRTFPNRPLFGLGFSLGANIITNYVGEEGPSCPLKAAIAVGNPFDLEVSNKALQRTMLGRVYSRVMGTNMKKLITSHKDEISQYTTLDYDRIQNITFLHEFDREVQTKAWGYPTEGAYYRDASSCDSVLGIKIPFLAISALDDPIAVHEAIPFQEFIQNPYTVLLTTSLGGHLSWFEIGGGRWHARPICNFLNRMANEIDLDSISPPANGQAPKSPQVTEFDPVRRKLRVLGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDX7</accession>
    <name>A0ABR3VDX7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000128">
        <property type="protein sequence ID" value="KAL1840075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="205" mass="22023" checksum="6C1484D33665E913" modified="2025-10-08" version="1">MASPTPIDMPIAGLSADQATAPATTGSCGSTNQQLSVPVFISSIIATATGTCLLTVLGLYLITHRHKFLTKYRRQKEAEALLEREAMSRAAEGLGLNIPPPAELPQESGKKAMTPAVSVHRALRPPVPAKDRRGVLRKAERPLPPTPHTSRSPSTFTDNTDQVYANILGRPIEPAMTRNVPERRPPASVPPVREDVGWPLSSGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE48</accession>
    <name>A0ABR3VE48_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000131">
        <property type="protein sequence ID" value="KAL1840004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="371"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="176"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1840004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="750" mass="82694" checksum="BFBA53B1DF3CCB84" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEB4</accession>
    <name>A0ABR3VEB4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="462" mass="50100" checksum="C8E3DDF8E6678DD3" modified="2025-10-08" version="1">MVAGVFSDQIDQQIQATTKFRKLLSKERNPPIEEVIKTGVVSRFVEFLRSPHTLVQFEAAWALTNIASGSASQTQVVIEAGAVPIFVELLNSPEPDVREQAVWALGNIAGDSPQCRDYVLSQGALRPLLNLLGDSRKLSMLRNATWTLSNFCRGKTPQPDWQTIQPALPVLAKLVYSLDDEVLIDACWAISYLSDGSNDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDIQTQVIINCGALPCLLSLLSSNKDGIRKEACWTISNITAGNSAQIQAVIDANIIPPLIHLLSNGDLKTRKEACWAISNATSGGLQKPDQIRYLVSQGCIKPLCDLLACPDNKIIQVALDGLENILKVGELDRQAAGEGAINQYALFIEECGGMEKIHDCQTNANEEIYMKAYNIIEKYFSDDEENADDNMGQPGQPQFGLGPGNGQTGGFTFGANGAESMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEK2</accession>
    <name>A0ABR3VEK2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3050</name>
        <name evidence="4" type="ORF">VTJ49DRAFT_676</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7691" checksum="14F6B285CC2F1FA8" modified="2025-10-08" version="1">MDSSKAPVKLVKVTRVLGRTGSRGGVTQVRVEFMDDQTRSIIRNVKGPVRVDDILVLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF45</accession>
    <name>A0ABR3VF45_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37997" checksum="6FB35DFEA061B2FB" modified="2025-10-08" version="1">MCFGRREKGDEAGAARSRELDKQIRADEKKMAKEVKLLLLGAGESGKSTVLKQMKLIYAQGFSKTEKMEWKPVKNMAQILVDYEMTAAEPLPEEYLMPVKKLWVDAGVRQAMERGNEYALHDNLEYFCDDVDRLWDKNYVPTDQDLLRSRLRTTGITETIFDLGQLTYRMFDVGGQRSERKKWIHCFENVQCLLFLVAISGYDQCLVEDKDGNQMQEALMLWESIANSHWFTKSALILFLNKIDLFKEKLPKSPLSNHGFTDYHGPPDDWKQASEYFRKKFQALNRNPDKEIYAHMTNATDTNLLKITMNSVQDMIIQRNLKQLILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF84</accession>
    <name>A0ABR3VF84_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZN622/Rei1/Reh1 zinc finger C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000114">
        <property type="protein sequence ID" value="KAL1840411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045598682" description="ZN622/Rei1/Reh1 zinc finger C2H2-type domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="ZN622/Rei1/Reh1 zinc finger C2H2-type" evidence="3">
        <location>
            <begin position="673"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1840411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="933" mass="104159" checksum="39830F34A16D8A4F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFD9</accession>
    <name>A0ABR3VFD9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000107">
        <property type="protein sequence ID" value="KAL1840569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="367" mass="40864" checksum="E1BAD0820FA9453B" modified="2025-10-08" version="1">MPDWDKEFMKAMEEVKKPLSPTVLPEDELKPYLDKHVQPSEESEETAAQKAERNALKVMVMHHMPRSLIESDFYRYASQGKHVAGWAGGIVKVVQSVSPVTREPRGQYFVFFDTENHAKAYRENLGQLPRLDEDEEAAAKRAQKRASKSGETNSTSTSEPFTFPTLAYTTPPILLSTSHLISLISHHLPLHPSPSTSPSPASASASPSPSTLTPRPFLSGTTNTLPHGLLEYAKEGGAALPKGAPVLLRLTGSKLTVEAMVRAIEEDGIERNLRWRLIENRPGTAGWPRPVQTVRAGSGRIGFGEFDEYNSKGEEDGNGEAQYGYTRFVVTLVDMGEARRFARTWNQREMVDERTERVVRVHAAELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFQ1</accession>
    <name>A0ABR3VFQ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="269"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="374"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="515" mass="53944" checksum="CBB4AF54B58539CC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFT0</accession>
    <name>A0ABR3VFT0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="354" mass="37715" checksum="07CF3110EEA5CA32" modified="2025-10-08" version="1">MPPGSLRCALPRSLVSPAINGSRIARTSALLLLPSSTPAPSTTAAPSRQYATAAPGGRLSLPPDYIPPTKPPTARPADTRKSQLLRSYTSLLRSTPLILIFQHNNLTAVEFAAVRRELRLALAAVSPEGSDSAEIASRAELQVIRTRIFDVALKIVEFYDPSKVQPSEATTITGKRVKVVYNHDLSKAAYKAVKAVSSGEKPLPEDSVYAQISPLMVGPLAIFTLPTVSPAHLAAALSVLAPNPPAFPPPSKKKSPGYYDPIAQSGLQKLLLVGGRLEGKVFDQQGIEWVGKIEGGIDSLRAQLVYLLQSAGMGLTSTLEGAGKSLWLTLESRRSVLEEDQKGPQEGGENKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFU1</accession>
    <name>A0ABR3VFU1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_457</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000112">
        <property type="protein sequence ID" value="KAL1840460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1840460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="544" mass="59975" checksum="ACAC9E1EC5360A0E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGI4</accession>
    <name>A0ABR3VGI4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_7701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="283" mass="31144" checksum="F2ED47627FE7B72F" modified="2025-10-08" version="1">MDHRPQAWGRPRDDVYGPYDASYLHTSMPKTATQSPIVTGTSVIAIKFKDGVVMAADNLASYGSLARFTDVKRLRPFLSTSVVGFGGDVSDMQFLDRHLTELAIDEAYEAEGCSAGDVSSSPSSTSSSDSSPNKNGQLNASNLHKYLTKLMYRRRNSFDPLWNQILVAGFDSASQPFLASVDLRGTAFTSPSLATGYGAMLAQPIMRKYAATEEDAARLTREEAVKVVRECMKVLFYRDARSLDRFSLAVVTKDGVEISEDEVLEEQSWAFAERIRGYGTQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGZ7</accession>
    <name>A0ABR3VGZ7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="86" mass="9660" checksum="B39B6607424977DB" modified="2025-10-08" version="1">MNAEDKRNSSPWRGDGRSEDFQSFVVRLKLVQPPCRHVPCLSVNEMFEGDGQIGQARQFAKSSTGWSEMKTVPGHWKRGPGELDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI21</accession>
    <name>A0ABR3VI21_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000083">
        <property type="protein sequence ID" value="KAL1841202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="271" mass="30081" checksum="2754223FCA0E2D4E" modified="2025-10-08" version="1">MVSAFQMQSFTYRTPLSVDTAQAQKIFEEEDTILDDNILDQSALDSGLEMSPSMVDSRRESFGVAPSLFSPKTEDWQSVDMQSVPSNNPFYNQSTNPFLPVDQTQPVIYQSQPWPMTATTSASATPQLQAFDGLPVEYDSAATNMAMFPRPGAPLQTPTNPFGTPVNPVGMFQSLGHPAPAAMPTSPQKDAWMAQDLKAQALKRARPASPLIRSHNELRRGDGIRKKNARFDIPAERNLSNIDQLIAQSTDEQEIKELKQQKRLLRNRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI55</accession>
    <name>A0ABR3VI55_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Trimethyllysine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="11">
        <location>
            <begin position="288"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="10">
        <location>
            <begin position="648"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="9">
        <location>
            <begin position="722"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1292" mass="143618" checksum="4EB6091CB12B785C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ07</accession>
    <name>A0ABR3VJ07_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045634543" description="NodB homology domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="54"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="264" mass="29445" checksum="E0E4AE6F33FB8B2D" modified="2025-10-08" version="1">MVSNLLRALLPISLLAWQAEAAPTLFGNLTARVQTRATTSVPRGVIIEHCTVPGTVALTFDDGPFIYTDHILDLLDYYGAKATFFINGENWSRAIHDDATPWPEVLQRMDAAGHQIGSHTWGHADLSILDSESREYQIYELERALFAIIGKAPTYLRPPYASCNWDCLAATERMGYHVVNFDVDPKDYLHNDASDIGSAMENFSNALDAQRWGDSFLVLSHDSLKYTALALVPHMLTEIQARGLRAVTVGECLGDPEENWYWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ90</accession>
    <name>A0ABR3VJ90_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">VTJ49DRAFT_6758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="301" mass="33556" checksum="A214B6691E4DBA45" modified="2025-10-08" version="1">MRPALRHLPRRAVRPTPPAPRPTLTAPLPSKSRPFTSTPPHNHNHTPSSASVNETEISHFSALASSWWDPHGPSRPLHLMNPLRHDFIQRCLSTSPESTPSSFKLRYLDVGCGGGIFAESAARLPSTQSVTAIDPSPTILAVAREHARRDPALVGSKGRLTYVNTTIEELPLPEERSDRYDVVTLFEVLEHVDYPAAFLDRVGEFVRPGGWLVLSTIARTWMSWFTTKLVAEDVLGMVPRGTHDWEKYVNEDELRGYFAKKGGQWGAPRVMGVVYVPGVGWREVTGSERIGNYFFGVQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJF4</accession>
    <name>A0ABR3VJF4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="144" mass="15633" checksum="2D21F0FB646EAEBA" modified="2025-10-08" version="1">MSTSSPSTQPDPMSSSTASSFIMADLQSSTSSTRSGSSRAPSSAHHDEDDNSDVDSLPSISSSILDGSSEDSLSDAQREWEASLEQLQLLLTMIVLPFAGKFLGRKFAYWSWARYMEWMHNVEIRWTSKTAFNVAGAAEAAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJJ6</accession>
    <name>A0ABR3VJJ6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF55">
        <property type="entry name" value="MEMBRANE ZINC ION TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="556" mass="58607" checksum="82E8DEBBBD3032EE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJL6</accession>
    <name>A0ABR3VJL6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7719"/>
    </dbReference>
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        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="236" mass="26608" checksum="6E3517304B90F5F3" modified="2025-10-08" version="1">MSSAKSHDSTTKRYNTMARRRKESPSNIKLKQPDRSGPTEKTLLQLAEERGLFAQAQNKKEIGKKHAITKDKESKTNGDDDEEGLPPTAERVLETILWSMSLAMLHFTLDVLVHHQYSVHAIVWSAVCRRFAQALLVFALLVYFLHPHPANPGLIPGLSSKYQTYVRQTLFFTTGTFAGCYLIHITNTYGYMAVMKQAPPIGCLWVWSIIELELPWAVLSLAGAAGFLWQRGYSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJQ5</accession>
    <name>A0ABR3VJQ5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="77" mass="8928" checksum="582F74A5C4E999BE" modified="2025-10-08" version="1">MTKIRPSTSSGHQRHEYLARPAPDLTSHQKKEHQRRPSPTSHQTKFSAQTLDPIQVQKRELDETKHPKRPPPDQDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJS2</accession>
    <name>A0ABR3VJS2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="601"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="904" mass="100485" checksum="DF792D57E485D27C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK27</accession>
    <name>A0ABR3VK27_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1346"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1280"/>
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        <location>
            <begin position="1301"/>
            <end position="1325"/>
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            <begin position="1347"/>
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        </location>
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            <begin position="1432"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1442"/>
            <end position="1455"/>
        </location>
    </feature>
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        <location>
            <begin position="1480"/>
            <end position="1493"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1516"/>
            <end position="1534"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1544"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1560"/>
            <end position="1574"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1636" mass="173596" checksum="BA7C911597B92967" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK56</accession>
    <name>A0ABR3VK56_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21656" checksum="A6833C79BFEF02FD" modified="2025-10-08" version="1">MASTVTSGSLVYERRVVERIHKYHWPAVQLNLWMLVMLIASCLIIGVFATFVQVQEVFGLPIPWYFPYYITVASLCVFFVLLLLWLIFQRRLLPSIVMIGGFILFVLWLVGLIVISIQLWGPAGSVGSDCNRLVFDRNPKPVGPTLDTLAWLQQKSMCQSWQAVFAFGLIGAIFLLWIMVMSYQVFVDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK66</accession>
    <name>A0ABR3VK66_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="113" mass="12552" checksum="AD400CDD78FB2828" modified="2025-10-08" version="1">MRGEATHTKVIYKGAHENFVVFIDGVPEFRQWLSDRTVPLSQVVSSFKVFTTHGGGTQGLLEGASKAVLENEFGTSNEDDVVQQILEKGNLQEFDMPERQGRKNDSNGPYVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKP6</accession>
    <name>A0ABR3VKP6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045123477" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="137"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="418" mass="45496" checksum="C336E2BE684F984B" modified="2025-10-08" version="1">MASFLWTLATLGAAFVPPAAAGPPQEAGGDIAQQRLLQMDCLPGPLIDDSYLPSCLATADSDDVTGPSPPWTHTPYCRGESNYCVHTSTNLYGPDHGVIIIDGGANKTDKAPAVLAVERIAGPDAATLTRRKEPDPPAWEVRDIPGKGKGVVATRKILRGQAFMIDHAAVVADMRFPERVNSVDGRDMLREGFERHPAGKELLALARSSRDPDNAPEDIIKTNSFSVEIGGKGYMVIFPKIARINHDCRPSALTRFNETDFSNTVTAFRDILPGEEIAISYSSFGLTSAGRRKTLRLKWGFTCSCSLCTAPEDELAASDARRTKIQQLNDKVMKLVEEGTSTTDKDVAKEKLNLAAELYGELVEAVEEEGIVPHMGDHHEALGRLVAAAGDVEKAREWLRRGREEREEFESIGRGEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKV7</accession>
    <name>A0ABR3VKV7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="189" mass="21588" checksum="77F4DE77CDA4B42E" modified="2025-10-08" version="1">MGCAESKPQESASSQPLLSTFPADLDLTTCTSFPMGHPFQAAGPSQLSSQHERLILELLPFKDSRQFHEWLTSIYVRGAWDEFVRDFLSRNPLAPEPDKARTAQKAKEAISSRKPQYLMYHPDKTGWTAEDHHIRFIVMVVLDNMLKELWSESEWKKRGIEIAKATYEVMAFLRATAFSPDANPPRYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKX0</accession>
    <name>A0ABR3VKX0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="64"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="288" mass="32563" checksum="B1E96EE730A4EA61" modified="2025-10-08" version="1">MPPASSPLSAQALASWDANATYWDHSITRDGNKYWRRLQEPSLSRLLAPTFSRAQDTRHGIRALEFATGNGLCARWLARQMRTLNPRGGGEVLATDGSEEMLKVARGYYEEEKGVVVRWRKVDVTNEEDLETLAREEGRFDIVLMNMAIMDVADIEPLARALRGLLSENGVFVATLLHPVFVTSNASRHIEVRNNPETGNLEVIRSKIITEYLSVPPYRGIAVPGQPEKQVYFHRPMNELFTTFFRAGLVMDAMEELAFGEEDALERIEASSNYTQLPFILSFRMRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKZ3</accession>
    <name>A0ABR3VKZ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair exonuclease rad1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37522" checksum="AAEC02DDC74622E0" modified="2025-10-08" version="1">MEGHSAASGPPILRAVASSTRPLYQLLKAIHFTNKVYVEITENGLRFAADHARVMQGEPINALGDTFVSLTELQDLPSPAPREADADGDEDDEPPAVTFQVSLPAVLETLQIFGAADAAARQARADLDPYRSNLRNYRADAFSNQTLGMSGTCAISYAREGEPFSIVLDEAGVTTTCNLTTYIPEAPDDIPFDIEDISFKIITSARWLLDALAELAPTGPEKLTIAASKREPFLRLSSSGGPLGSSSVDFAKGRDLLETFSVGGRWVQTFKFDIIKSACEAMRIASKVSLRGDGQGVLSMQFMVEVEGSGPSFLDFRFVPYAVCDDDDEEEEEEDEEGESRRTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLA9</accession>
    <name>A0ABR3VLA9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_4764</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000038">
        <property type="protein sequence ID" value="KAL1842584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="375"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1385"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1396"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1464"/>
            <end position="1475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1842584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1715" mass="190931" checksum="563012069961ACEC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLG6</accession>
    <name>A0ABR3VLG6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="438" mass="47986" checksum="8794C7A0EC93BD8F" modified="2025-10-08" version="1">MAKKSATQSPKAGSKLKSQAVNGKSAEKKKDNSRRKSAKQPTVEKMVVDNEELEESSSEDEVPEANGKKEEPRSDESSEEDSGSDRDSSDGSGDEGFGHIDIEAIDDSESESELDSDGEDERVKITKQDDSEDDGEGEDDEEEEIDVDELEPEDEEDEEQIAAGTRVRQTINNKEALLTSLRRFALDTDPKTVPFAFHQTVVSSKRTEDSIPSVEDDLQRELAFVNQALEAARQGRALLRKEGVPFTRPTDYFAETVRSDETMQKVRAKLVEEATAKKAAAEARKQRDLKKFGKQVQVQKQLERAKQKREALEKINLLKKKRATNGSSTLGATEADDLFDVAVDNELNASGASKKRKSPGDGKGERNAKRQRKDAKYGFGGKKRFSKSGDAISSGDLSGFNAKKMKSGSFGGGGGGKKKGVKAARPGKSRRKSMAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLT5</accession>
    <name>A0ABR3VLT5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_5289</name>
        <name evidence="12" type="ORF">VTJ49DRAFT_7627</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000094">
        <property type="protein sequence ID" value="KAL1840929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000043">
        <property type="protein sequence ID" value="KAL1842441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="33"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="259"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1840929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="491" mass="56629" checksum="D7672193759BB811" modified="2025-10-08" version="1">MPLARSDSLQDIDFTLRRQFNKTSFRPHQRDIILAALDGYDVFVQAATSFGKSLCFQLPAVIDRGITIVISPLLSLMMNQVEALRAANVDARTLNSNTPMPERDYIYRDLATGHPRTRLLYVTPELCSMDRFRDRLKLVHSQKELARVVVDEAHCISEWGHDFRKDFKRLTWFRDTFPDVPIMCLTATANAQVRGDILSTLGLDRTPGRLRNFTMTAHRPNLHLEVRFTSDEANDRYDDFVNWLKGVYTRRKTDDRRAELEAVGERVENVPGIIYTLSRDECESLAAALRCEDIGARPFHAKLPKEVKEETLARWINNEPGYDIIVATTAFGMGIDKENVRFVVHWRLPKSFEGYYQEAGRAGRDGNASYCFLYYAREDRDRVCNMLMRDATTALAGTRAANAALAKDTNLQARMRSLDRLVEYCESTDGCRHAYICRYFGEEEVPECDFACDWHKDPQDLKRRMMRGLASEEWVSTQRMEGAYDDYYYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM29</accession>
    <name>A0ABR3VM29_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000040">
        <property type="protein sequence ID" value="KAL1842531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="930"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="950" mass="104304" checksum="44486E805378AA50" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMN4</accession>
    <name>A0ABR3VMN4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="54"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="473" mass="52581" checksum="55DF20C801491F93" modified="2025-10-08" version="1">MSSTLLLETKSAKDAASSFQIADRAGHNFVHMRQWEGFEKSLANPWTPETPDGLVNLGVAENTLMHQEVVEFMAKNTVVNPISHLSYGSGPKGSPRLRRALASFINSGFQAREPVRAEDIIVLSGVTSVVDNLAWAILNEGEGIIIPQPFYSGFAVDIPTRAHGVIVPLEFQKLKEYSGFDDVFDPAMNVKALEAALEGAKEKGIKVRAVLVTNPHNPLGRCYPVETLLEIASFCGRHGLHLISDEIYAKSVFSNPRARSSAPFASILSIDLTDRIDSQLVHVLYGASKDFCANGLRLGILHTRNQGLQAAIASTSMLAWPPYLIQEVWAGMLEDEAFTSNFLETNQKRLAEQYAFTTRRLDEYGIPHYDNTNAGMFIWIDLRRYLTGKAEVAPGELSLHRLTAEEKEKYLQRESELGRRLFKNGVNIALGTWFATEELGWFRLGYTVPREALETGLERIRKTLKDVVASGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNZ7</accession>
    <name>A0ABR3VNZ7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="66" mass="7111" checksum="1D0A3EAD3776E6A0" modified="2025-10-08" version="1">MQPQPAPNGPQGTSTDDAHGPTSPPDLQLISCSPGSAMSPQWGTDERHPPNRTKVMEVMCLEVRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP17</accession>
    <name>A0ABR3VP17_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="558" mass="63357" checksum="4E18696F6DBB04BD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP87</accession>
    <name>A0ABR3VP87_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000033">
        <property type="protein sequence ID" value="KAL1842761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="145" mass="16088" checksum="9422FC91D4ACEEFF" modified="2025-10-08" version="1">MLTLYDGTSPSTSNDNHFLRIGQLWAVDGHLRSTIRANCPAFKEISGCVEDSHIDALSPLGLVKEINITSGTSTVTAAALKRLWRANVGPDDELRAKRRDNHWELRMELICGGGFPNISKEGFAEVESDVYENFRGGVILDTVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPE7</accession>
    <name>A0ABR3VPE7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="160" mass="18278" checksum="E2921BE86B271FBB" modified="2025-10-08" version="1">MSDYGNDDDRDRDLNDEPAYEDDPDEYYEPEPEPADEDEAARAQDQDGENPDADHVIASGDPNAAANHGRGNEKSHKDKKIPNDQRTTTPFMTKYERARILGTRALQISMNAPVLVDLEGETDPLQIAIKELREKKIPLIVRRYLPDGYYEDWTCEELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPL2</accession>
    <name>A0ABR3VPL2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000024">
        <property type="protein sequence ID" value="KAL1843123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="34578" checksum="DD891CC0C831347D" modified="2025-10-08" version="1">MDAPEVISGPQRSLSYMLRRQPQLKLSIPSATGGGNTIINSPGSYDEYEYGLPKRDATRRITAEKEVGGLGREKRMRSRGSSSFGSGTGFRPDLGSGSALPALPPRPEPRRRFWGRRKTVWCLAMLAVVLVAAIGGGVGGSLAARRAAANQNPTIVMMPTTVTMMPPDMPTATAGETAASPNSSSNTASTASTPSPTPDTVQAAAIRVPTEGVIDFPCGRMSRDRQMVTLGTATWGFDVHCMMDYAAPGIDIAGMTAYSFGDCIRACAMLNRFARNNTCVGVFFSANLTTSLPRHGANCFLKSSLSEMTVHEDLAAAASLASAPQFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ37</accession>
    <name>A0ABR3VQ37_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7102 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055528">
        <property type="entry name" value="DUF7102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23394">
        <property type="entry name" value="DUF7102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7102" evidence="2">
        <location>
            <begin position="680"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="848" mass="93908" checksum="215D13456793B3E3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ98</accession>
    <name>A0ABR3VQ98_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045477674" description="CREG-like beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="3">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="3">
        <location>
            <begin position="192"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="312" mass="34375" checksum="3E54EBC1CE29B438" modified="2025-10-08" version="1">MKAATLTTALLSSLTTTASAAAVLPKSNSNSNHQHVSTSRIPTSYESAVLGRRILALTPIGTLATVFQEGDEKQHRPDGLDGQPYNLMEYIADCEDEGNPTILAFPIGTTFHNAAAGSNVSLAVRWTPPPPPRHKGGEGDGKKSSWLDWLGLGRLRKQHHRPHPADFDIDVNSDSDSDSDSDSDSEDDHRHAPPPSPFAHSAAALPRFSLIGHLEPIPDGDDRSTPTGKALAACYTKTHPDARIWLPGNRIHEAHFVRLVVEQVYWVGGFGNVAYIGWIPVEEWKKVTREEWEKVRLPGERNHWREFDGEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQM9</accession>
    <name>A0ABR3VQM9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF6">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="153"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="257" mass="27638" checksum="8F7AFD43190345F7" modified="2025-10-08" version="1">MSSNSSKPSPGLWQPNPYANYPGPDHTAFLASAATATEEDESDPILAEANARATARQIAFFRSIPWCAALLDKPGLTIQQAESRRLNRTALDALCSRTLNQPGAIPAYVIFYDPNEGLSSSHTSSSSDDKPLPLITQVSSLVALGPLVNGWTGICHGGIIATLLDETLGQIFAANGRHGRLPGKKAAAVPVMTGYLNTKFVRPVRTGTVEAPRVILVTSRIVRHEGRKFFMKADVRDEKGAVLSEADALFVMLKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR70</accession>
    <name>A0ABR3VR70_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PPK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084">
        <property type="entry name" value="YALI0E26631P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="636" mass="68602" checksum="9D194BF7412AEAC0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR75</accession>
    <name>A0ABR3VR75_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="10">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2354</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1844297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="764" mass="85811" checksum="6890D3938833052E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR85</accession>
    <name>A0ABR3VR85_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="376" mass="40388" checksum="E6AFDAD756A6800B" modified="2025-10-08" version="1">MLEVIYVTRHGFRSNWLVDPSNGSYTPYIRSPTGVGADPALTAHGVDQANELAVRLLELDPPVERVYSSLYYRCLQTVEPFVRKTQEVAQTFISSSDSSSSSTGPATGTGAGAGTTGAAARLPLRIRGETGLGEWYGSADFDHPVPAPLEKLDELFPGLLKLDYRPAVTPNRKGESIDELHERVAAALEALIAECDRDGVRAVLLCSHAAVIIALGRVLTGQMPDSHDVEDFKCFTCGLSAYRRRRWLSGSGPAADGASVDQRRRDGPAGDWRGGRGVSGGWDCELNSDCRHLSQGEERGWYGSHIFVFLGSKVSLLLKTQANARRRRFSGDESFKHVPTGPSLLDAGTRLGEDAGNSVSGTEGSGELGEGVRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRK3</accession>
    <name>A0ABR3VRK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="114" mass="13254" checksum="543E6AB3F0A28BD2" modified="2025-10-08" version="1">MSAVQKAARPESAAQVLSLYRQLLRQGQQFSAYNFREYAKRRTRDAFRENRNVEDPRRIQELVQKGLKDLQMLKRQTVISQFYQLDKLVVEGGISGKDQPGHGETVRQKDTGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRQ9</accession>
    <name>A0ABR3VRQ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_28</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="298" mass="31432" checksum="8E05F94D8DBE2339" modified="2025-10-08" version="1">MDALRSVITPITHNLPGPIRDLGEAIIGDTCYKAILLDVDLENTACLKLAISKALGIGIVAASSIVKVPQILKLVNSRSASGVSFLSYLLETSGYLISLAYNVRNAFPFSTYGETALVLGQNVVITVLVLNYSGRASVAALFVAALAVSIVTLFSESLLDMQKLQYLQAGAGALSVASKVPQILAIWQEGGTGQLSAFTVFNYLLGSLTRIFTTLQEVDDKLILYSFIAGFTLNTVLAMQMVYYWNAPSAKAKGKQKEKVPVPAAAAATTSSTTAGPTATATGTTTPKSKGPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0Q4</accession>
    <name>A0ABR3V0Q4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000735">
        <property type="protein sequence ID" value="KAL1835326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="401" mass="38954" checksum="2CA165B6584B37AB" modified="2025-10-08" version="1">MSWSMGAPSSEVPCMGTSSSGEPSMVPDTATATGAGAGAGEEGGRAANKSPSRAADMSRTKLSKTARSSTPVPVISWSRSSTGASSTPVDVPQTTSSPTSMGASPSKGAPGAAATEPSTSIMSRSSEEASGRDEVDGVKMASACAFTTRAGSSAMIASSAISAVSVRCEAASGSWAGCWRSAVLALSGAAPFCSSSVLGWVPSADEAASTGIDSPGSAKRTVFFTLGPPTLGSATVAVVGCWRSPLPLAFLSSGVSGAARSCSSAGRDWMSRGDGVAASPDAIPSERVGLSGALGSAGVITVVAEVSPGDGTTGADAEEMTFTGSSCEVGSSVAAFTGSSEEVGSSADRQATSSASGAGSATEAASASLSSRRSDSASRLSSACAVSRSARRAATAARAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V124</accession>
    <name>A0ABR3V124_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000637">
        <property type="protein sequence ID" value="KAL1835493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="68" mass="7381" checksum="7BA961A008B1A46D" modified="2025-10-08" version="1">MPESPQETPAFGPLLNCRSPLLFRVQGPVRRLVPCSPATTITTSTNELPQSSRDSAMQPLPSMEEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1U4</accession>
    <name>A0ABR3V1U4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000569">
        <property type="protein sequence ID" value="KAL1835674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="86" mass="9670" checksum="01C6EAB3AA97985D" modified="2025-10-08" version="1">MWGVEQPIIFRVLHIRSGTLRWVIGPEEPRGGDSEIRKLPVGSRGLRLSCRRKRHGTPGVSVRNALPSRRVPMHSTALLRWPSGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V274</accession>
    <name>A0ABR3V274_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000632">
        <property type="protein sequence ID" value="KAL1835501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1835501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="84" mass="9189" checksum="77181C77CE67210C" modified="2025-10-08" version="1">MYLHRALAPPLVSNHIGTITQYPGRRIQAVRENQNAVGLARERHAPLTAENVTRQPACMALWACYILTAFPGVDGHARPSDADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2B7</accession>
    <name>A0ABR3V2B7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000517">
        <property type="protein sequence ID" value="KAL1835882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="170" mass="18352" checksum="4BD0168C4583E7F2" modified="2025-10-08" version="1">MFSRAAVLSRAVRQPAVTSSLFRPAAAAAAPSPFSLSFAAAAQRRLLSDSVRQAIDKAVASAPVVLFMKGTPETPQCGFSRATIQVLGLQGVDPEKFAAYNVLEDPELRQGIKEYSDWPTIPQLYIDKEFVGGCDIVVSMHQSGELAKMLEEKGVLLKEEAPAEGEKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2I7</accession>
    <name>A0ABR3V2I7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000488">
        <property type="protein sequence ID" value="KAL1835984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="4">
        <location>
            <begin position="82"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="279" mass="30216" checksum="FC6D221FAE862AB5" modified="2025-10-08" version="1">MASQPTTDTASTPSNTTQPTTPSDAAILSHLENYFATRSVASPIYAYLLGTPSEPQIRFTSASKGVFTARLTLAAHHLNSGGGLHGSVSATIVDWAGGLAIATWDLRAGTGVSVDIHVEYLSSARLGDEVEIEGRVDRVGRSLAFTEVRIWKVDGEGRRGGLVTVGRHTKYVKESLIRDPAKNGDFTVQRLCLPITAHVPSETIKRIIVDYEYVLAYAETVLQDCIQGVSIAAHRVSIKESEKAIAEARDVTRLTRLATVFCALDLCDVCVRHERPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2N9</accession>
    <name>A0ABR3V2N9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000609">
        <property type="protein sequence ID" value="KAL1835548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="177" mass="20442" checksum="077DD08E945B451B" modified="2025-10-08" version="1">MVPEDAELLRLFTVHELMRWPEVARVFGPHLLSTDVFDSAPGQSADPQAHERWQDLRKRVIEHNVRVIAKYYTRIRMDRLTELLDLTEDETEKYISELVTAKTVYAKIDRPARVVSFAKPRDADDILNEWSFNMKSLLGLLERIDHLITKEEMMARIQQPGGGKSKKGKEAKKAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2Y8</accession>
    <name>A0ABR3V2Y8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000459">
        <property type="protein sequence ID" value="KAL1836138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="275" mass="28728" checksum="65AF225745309895" modified="2025-10-08" version="1">MRALLLTFAPPGQDGVRSSMLSYTLDNMRQTQDQTPAAAAAAVVTTIPTMTLSHHKSRACYKCGDLGHQADQCASPHRLCYNCKQPNHESNECPMPRTTKAKQCYHCQGVGHVQAECPTLRLSGGANRCYNCDAVGHIARNCPNPTVPGLARAPVRGGFAHARGGFVGGARHATCYKCGGPNHFARDCQAQAMKCYACGKLGHISRDCTAPGGGPLNTAGRTCYTCGKVGHISRECTEGPANANGEQKTDADVNGAAPAAAPQPIAPPAVSATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V394</accession>
    <name>A0ABR3V394_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000548">
        <property type="protein sequence ID" value="KAL1835743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22564" checksum="2D1F0241DF7AC59F" modified="2025-10-08" version="1">MAADEGKNGVSAAASHAERLEAQIKSADMTEDMQQEVVEVAQEAMAKFSIEKDIAQHIKRTFDERKGPTWHCIVGRNFGSFVTHGATLSPLVLGQSLAKDTFSLTPGPTKPAVVMAQQRRSTSSTSTSATTPSCSSRPSREAASSVGSRSCEERRLPPNTHHHHHHHHQNRLKEAGEPTLSTSTRKRKRTEGDTVMYIHSWGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3D1</accession>
    <name>A0ABR3V3D1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein fta4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000435">
        <property type="protein sequence ID" value="KAL1836288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34027" checksum="CFBCDA9EF4BB88D1" modified="2025-10-08" version="1">MAPNPPTILTLKQSFLTAQTRLLSQPLSPSPAWLDDNKNNNDPDNPPLPEKAVHDALFKLNHRLQQHARRVYPPQATRHVAEQIDQLYWNAAEAVVGGGESEGEGEEDIEALSLGADLTNPSTITTLPPTWDSDSVNTNPVAREQYASLASTLHSLAERKQQAAARVARLRRMRALLEPFSPAPASGSASSSAAAEPSTSASGMDFDVDVDRDADPDGLKTVQENLVTRNGALEKELLRMRVLLARVSGRAELLKEQQQQSSRGRKRGRDGDQAGRTESPSSAGSLFSERPGAGAVEDVEVEERRKVGALLESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3I4</accession>
    <name>A0ABR3V3I4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-threo-3-deoxy-hexylosonate aldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000528">
        <property type="protein sequence ID" value="KAL1835833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="35679" checksum="EB28C40D0E6A283D" modified="2025-10-08" version="1">MTATNGAAVAANGNGNGSARPRRPLPCGIYAPTMTFFDPETEDIDIPTVKKHAERLVRSGLVGLVTMGSNGEAIHCTREEKFAVTRATREALDDAGFIDTPIIIGATEGSVRGTVELCRLGHEAGADYALLLPPSYFRALMDEQAVHDYFVAVADESPLPLILYNYPGAVAGIDMDSDLLIRLAQHPNIVGTKFTCGNTGKLTRVALVARAKTPWDQGSGYMAFGGMCDFTVQTLASGGSGIIAGGANVMPKVCARVWNLYVEGKREEAAALQRTLSKCDWVLTKSAIAGTKQAIQSYFGYGGHPRRPLKRLDAASVAAIEEGIREVMEIEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3J6</accession>
    <name>A0ABR3V3J6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000432">
        <property type="protein sequence ID" value="KAL1836300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF11">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="511" mass="57490" checksum="501314043B2A9610" modified="2025-10-08" version="1">MGPAALEVKGPFHVFGICYLALSQHHGSGTRRFLPCQDLHSALPAMLDLVGFIALSVLGSIVTVVLTLGKRSQDLPSFKSRALSPASWQWSKVSSLWHGSGDATNHEPNSRQLLGEIQDLAECHETAGLLTDLIRKDGAGEWPPRSNHAHTTWPAPLRAYRGIYEEMLPLLAVAKPSLDDDVNRERIAAFRARFGELLSQRVDLPAVEKLLQAAEAVRVAQLERIVPLPHELTLPWTYQQRHFSLTSDSGNNMSNLVLNFTPSASYSLRINDPAAQSATITRSEEAFARIFYDVEALGLPVYHAVIHAIRARCRGDTVACLHHVRRITRHLRPLLRSYYDRVHDDAIARSAWLSHVQGFYGWGAGYEKVVEEEEEEPQWVKFDGLSGNQVLLFQVLDAFLGLPPYLDEETQRRNVPVMQREFVKAVGKHSFRRGLEKKEGVEGMILEEMGEILKRLRLFRTAHRTRAKVYLTQPAPERLPMTAGKSLLKSDMDTSLEYLDEFMLGRLAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3V409_HUMIN</name>
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            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">VTJ49DRAFT_5057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
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            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000401">
        <property type="protein sequence ID" value="KAL1836517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="143"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="262"/>
        </location>
    </feature>
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            <end position="330"/>
        </location>
    </feature>
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            <end position="363"/>
        </location>
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            <begin position="612"/>
            <end position="641"/>
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    </feature>
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        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
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            <end position="596"/>
        </location>
    </feature>
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            <begin position="382"/>
            <end position="494"/>
        </location>
    </feature>
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            <end position="419"/>
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    </feature>
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            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="735" mass="80693" checksum="472A5704723BB481" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V449</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">VTJ49DRAFT_5024</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="LEC1-like"/>
    </dbReference>
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        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF2">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX-associated" evidence="3">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
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            <begin position="182"/>
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        </location>
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            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="792" mass="86225" checksum="9B4F0F6EA84CBE4B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V489</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Mondo S."/>
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                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Conant G."/>
                <person name="Drula E."/>
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                <person name="Hansel C."/>
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                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1836584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="206" mass="23045" checksum="D578C20317E95726" modified="2025-10-08" version="1">MATIREAAEADMALHGRPFATTVRRSFARMLLRREDECHPQPGIDLCEKPSVSSVQTTWIIVGTVLGLLLVVTGSVLIFLHIRKTKRDKREDVEDRFHRADYGLDDLPSSRKPPADDDMTDSSSAMGYGNRPRSRDPLQGGAEPKYQNGQNGGGRGRQLNPFDDTSSLGSIMVYGYRYHIGDFALITQALDLLAKKFRCEFVMKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V514</accession>
    <name>A0ABR3V514_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000396">
        <property type="protein sequence ID" value="KAL1836561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="574"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="650" mass="68410" checksum="E69B65A07CF5F307" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V530</accession>
    <name>A0ABR3V530_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000356">
        <property type="protein sequence ID" value="KAL1836874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14076">
        <property type="entry name" value="STKc_Kin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034674">
        <property type="entry name" value="STK_Kin4/ppk1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="168"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="828"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="894"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="932"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111584" checksum="3B12401C6DA82BDA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5D0</accession>
    <name>A0ABR3V5D0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000344">
        <property type="protein sequence ID" value="KAL1836970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="240" mass="26687" checksum="F3F8E3E7B4DEBF51" modified="2025-10-08" version="1">MADVPLYVVSDYASSERRINPSWSIAQLKTKLEPITGIPPSCQQIFYKPSAAEKIPVEAPNEEAVLLQQFNLTPYAELLIVDTRPPSARPNFSSTEGVERFVLPDEEYEQRTDSVLAWKKAEKLGRFDPNAPSREQAKIDAIAKEIEARGIAVGKRCRVGGEDARRGQVMYVGEVKEIPGVGAWVGIQLDEPVGKNDGSINGTRYWGEESELKCGLFVRPDRVEVGDFPPLDDLEDLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V697</accession>
    <name>A0ABR3V697_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000310">
        <property type="protein sequence ID" value="KAL1837289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1837289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="586" mass="63127" checksum="51F9E1D8845B39BF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6H1</accession>
    <name>A0ABR3V6H1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000304">
        <property type="protein sequence ID" value="KAL1837345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="267" mass="29910" checksum="C7C2C378574FEFDC" modified="2025-10-08" version="1">MTSTMAPPYLLPVTQWAGIAMPTLFAGITFQYSLTMHLLTCIATTTTNGTPSSSELPSEFSSKESDSDNPLKNQWNLARQWYILYRQGPRWVPPIVLSGTLSNLYLYFFAPNKQPSPHIRHSLLAAAALLTFSILPITFFYFEPGINGACKRKYGQLSKRMMEACDEKGPSRQAEDEDEQVQGEAEPARKTNASKQDEGFFARQWRTYIPASVNRHTGTLAAKVWAEHTDMAELVEGWVRRNHVRWVIGLVAGGLSFLGSQGLCSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6Q8</accession>
    <name>A0ABR3V6Q8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000293">
        <property type="protein sequence ID" value="KAL1837449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="155" mass="15619" checksum="D4C9D53EBEB74ED7" modified="2025-10-08" version="1">MASIPPATHMLRQVGNFVSSGAAPNPQSGVAGRGSSGNNNTDQQFYVNVIRRNNGRSQVHLYYGRTPSSSSTQSAQSGQSGQLISGNTPIQPQAAGYQGNGALAAAAATAATARLAAGRNPSHGSAAAFSQVVNSAVQQVAASALPQMARRAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V738</accession>
    <name>A0ABR3V738_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000279">
        <property type="protein sequence ID" value="KAL1837600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="4">
        <location>
            <begin position="235"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="530" mass="59704" checksum="4749DAFAA574A93F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V796</accession>
    <name>A0ABR3V796_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000274">
        <property type="protein sequence ID" value="KAL1837658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047522795" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="31858" checksum="EFC07D105FED905F" modified="2025-10-08" version="1">MDSFKMLLVRAFIAAGGLATLTAAHMELFNPPPFPGGNNSPVSAGNFPCQFGPATYDRGTTTPMKKGEPQKMSFKGGASHGGGSCQISITYDDPPTKDSVWKVIHSIQGGCPARKGDDHIGGDAGMLGSDSYDFQIPDIVPDGSATLAWSWINRLGGVPEFYMNCAPINITGGGGDASGLNSLPDMFVANLPGITDCVIPFGSDLKYPNPGSSVETWEQAKLLEPTCSFYIGGGGGAAPTPNPAGENSPASASGAMSATMDPSGTAAPAASADASSMPGGAQSMSAGAGDSACSGGAAEPTPNPAPYIRGRRPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7K9</accession>
    <name>A0ABR3V7K9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000277">
        <property type="protein sequence ID" value="KAL1837625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46068" checksum="8C2CE00D09B5C351" modified="2025-10-08" version="1">MMKEAADATGLEIDDSGSGSGRGENDSNDGNMGASRSVYAMSLYPGALRTARQQSPLSSGENGQDGATIDSARTLYAEDFDFVIENGRQYCGDYFMPIDQEEQIRQYTIHETYLRLFNKQLTTVPLDNPRYILDIGTGIGEWAIGMAEKYPRAEVFGTDIAPIQPQQQVPFNVEFHIEDAEDEWIRPADTFDLVHFRNLEGAFSDWSFVYNQAFACIKPGGWIEILDWEDWFADRNYLSFFPEGSAPHALVRAVLRAAEAAGKPRGASHLNPDLLRQAGFVEIRETVYDMGVGARDDANYGQFWLFSIVTGFEAQCLRLLTKHLCWDADDVRRLCREVALETKMVADDPHRTEPFVVKLRVVVGRKPLLGEEPEQVVGLQKTGYGGINGGDARDLSGDESTIGPRTIHSEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Q5</accession>
    <name>A0ABR3V7Q5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000263">
        <property type="protein sequence ID" value="KAL1837785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055795">
        <property type="entry name" value="DUF7371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24086">
        <property type="entry name" value="DUF7371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046342684" description="DUF7371 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7371" evidence="3">
        <location>
            <begin position="834"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
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        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
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        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1041" mass="106420" checksum="5C5745A70DDEFE06" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7S5</accession>
    <name>A0ABR3V7S5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="10">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4222</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000325">
        <property type="protein sequence ID" value="KAL1837138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="414"/>
            <end position="459"/>
        </location>
    </feature>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1837138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="832" mass="90331" checksum="46797274E284332F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7X0</accession>
    <name>A0ABR3V7X0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein SH3</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_4174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000320">
        <property type="protein sequence ID" value="KAL1837183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26339" checksum="65B4032EA85A18DA" modified="2025-10-08" version="1">MPAKWVDWSKTTRSKDYRGSGSFATFLIIGPVCFFLGILFASFPYDFPLLWTSDPLPDPAYLDHLETHLRFMHQAPPLIARMMHMVMFVGFLGFFVKLFRPSEANVLFDGAGLVLYLIGAGVYLSNIVKGMRAVSQPGGLAAAAERAREAAAAAAAAATGNGAAGSAGANPGFPVHHSGPLTGEIVLGREDSLRVLSASHVILALVLVGVLVLQAGQWYAERKEADDVARAEREAAERAAAAGKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Z7</accession>
    <name>A0ABR3V7Z7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome-associated complex subunit SSZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000258">
        <property type="protein sequence ID" value="KAL1837847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="488"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="62847" checksum="60B5C5EF72A955E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V888</accession>
    <name>A0ABR3V888_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3323</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000258">
        <property type="protein sequence ID" value="KAL1837850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="331"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="335"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="557"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="687"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="832"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="722"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1837850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="878" mass="97087" checksum="406D760EA2E1A173" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8G3</accession>
    <name>A0ABR3V8G3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_3034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000238">
        <property type="protein sequence ID" value="KAL1838103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1142"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1241"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1339"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="523"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="753"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1128"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1416"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1533"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1545"/>
            <end position="1561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1838103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1674" mass="183827" checksum="396048633675217A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8J8</accession>
    <name>A0ABR3V8J8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000234">
        <property type="protein sequence ID" value="KAL1838154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="206" mass="22136" checksum="5D61DCB8AC66CC08" modified="2025-10-08" version="1">MGKLPSTLLRRPCLTGRLPTISPGFTHTPLAPLIPSPATTTITPLPTLRPTQVRHATFIPRHRRPYQFTQLVQLSDGSTFTVRTTSPQALYRSDKDSRNHILWNPSEASLRNVEVDEAGKLAAFRERYGTAWDLEGGAGKGAAPAAGDKDAAGKKGEAKDAAAPAQEEEQHDSLVDLISAFATVDNSVKGGMSAKAQAKLEKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V933</accession>
    <name>A0ABR3V933_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="12">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3268</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 12">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="12"/>
    <dbReference type="EMBL" id="JAZGSY010000253">
        <property type="protein sequence ID" value="KAL1837901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="13">
        <location>
            <begin position="90"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1837901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="564" mass="61924" checksum="6F1AE24B6EBA6A4C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V976</accession>
    <name>A0ABR3V976_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000275">
        <property type="protein sequence ID" value="KAL1837648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
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        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
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        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
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            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="180" mass="19915" checksum="64715F88CA713071" modified="2025-10-08" version="1">MKVLESQNALLSNYEVYQHTLDQRRNNKANNRRVPANAHKIMNEVSSPNPLTTLTSTLTIPQVMTYLTTKPSPLANQEEKQDYTPEAIPRLLERLREADLPGELTKGELLSILNLRPSSSALLSTAIEDMEERFSEDEQNRIVDVIAEVLGRSDPAEADGEGELDGEGEAEAVPSVENGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9A3</accession>
    <name>A0ABR3V9A3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_3528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000273">
        <property type="protein sequence ID" value="KAL1837678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="102"/>
            <end position="230"/>
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        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="230" mass="24506" checksum="D0316C13DDA4D224" modified="2025-10-08" version="1">MMNSESHPVTTTGGPPPGPVPQQTTTTSDQTPNTHNNPQPTSAHGPALPGRPPGRVGRPQLKQEDLIRIQVLYKDAKWGPTQIARHTGYTFHQVKYALKKGTTTVGVRTGRPRKADLTARSAVAAQTSQAQAQGAQGGQEVTTSGDQLQGQEQQQQQVPPPPGPGESTQGAEGEETWGGKEVGEGMDVEEDHSQFEANQPQPSASQTTREQAGEPEQRLMEVQAALQSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9B4</accession>
    <name>A0ABR3V9B4_HUMIN</name>
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        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000247">
        <property type="protein sequence ID" value="KAL1837976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="825"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="119"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
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            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115964" checksum="0B2CBDDCE93286C5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9G4</accession>
    <name>A0ABR3V9G4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2638</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3 8"/>
    <dbReference type="EMBL" id="JAZGSY010000212">
        <property type="protein sequence ID" value="KAL1838470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="454" mass="49820" checksum="B63C3F0C986CCB38" modified="2025-10-08" version="1">MHFARYGAAALAGAAVADAAYSIATIADIKKTAADVAWDLMQYYHGNETGQTPGILPGPPPAGDYYWWEAGAMWGTLIEYWKYTGDDSYNAVITQGMLHQVGPNRDYMPPNVTASLGNDDQGFWGMSAMLAAELAFPDPPEDEPQWLALAQAVFNTQASPDRHDEECNGGLRWQIPWSNNGYDYKNTIANGCFFNLGARLARYTNNKTYAEWAEKTWDWVEGVGYIDDEYNVYDGGHVQYNCTDINLAQFSYNSAIYLLGAAYMYNYTQGSAKWRDRVDGLVDATIRNFFPDGVAYELPCEEKMTCTTDMLSFKGYLHRWMATATQVAPFIAPKVMPVLRSSTEAAIATCTGEENGRTCGFRWSWRKYDGSKGAGQQMNVLGAVSSLLVEYVPGPVTNTTGGTSKGDPNAGSKSDNFRRDPRPITPGDKAGAGIVTAFILLSAAGAFVWMSIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9N7</accession>
    <name>A0ABR3V9N7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000215">
        <property type="protein sequence ID" value="KAL1838431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="160"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="456" mass="49431" checksum="F803398F737A8FA0" modified="2025-10-08" version="1">MAAASPDLEKQAAPVATGREDHPSSSETTTTTTTTTTTTQEISQPRPSSDSNILSTLEEYAYGRPITTVQDLAPEPASELDDDDEDEDDEDAHSHSSHHSHDEEGENGTTANPITHHLTHTATLTSVASAASRPPDFEVTFSTDDPENPRNWPLWYRAYTVLAVSYATWVVVLYSTSYTATISQVMDEFDITSRPVATLGLTTYLLGLAAGSVVVAPLSEVYGRRVVYLVCLGIFTVLIVPCALAKSLGALIGVRFIGALFGSALISNSPGTVVDIAGHETLALCMSWYSIAPLNGPVTGPLIGGYVGEGLGWRWANWLALILSGVAFVMVALVKETYAPALLKRKAERLRKETGDERWWSRHDQRVSTTALLRANLSRPFVLAATEPILWFFNIWISIVYGILYLCFVAYPIVFTLHRGWSVSQTGLSFLGIGVGTLFAISLEPTTQPPKPPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9S9</accession>
    <name>A0ABR3V9S9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">VTJ49DRAFT_2601</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000209">
        <property type="protein sequence ID" value="KAL1838527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="383"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="644"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="740"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="873"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL1838527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="980" mass="106149" checksum="087611036BAD14E9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9U8</accession>
    <name>A0ABR3V9U8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000255">
        <property type="protein sequence ID" value="KAL1837888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="762" mass="86692" checksum="FC97F51E6D8CE6D0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA18</accession>
    <name>A0ABR3VA18_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000212">
        <property type="protein sequence ID" value="KAL1838465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="488" mass="52227" checksum="30F717002FE4BF88" modified="2025-10-08" version="1">MAALENVKSHNMQRSAAPLPQTAAAPFFSRSSSFFGGRTKPRSQSEDRPVSPTEKTHRPTISNDSTSERSSQEHHKERNVLVKKPSLRRKPSFRFTLSTSSHDKPNRHRADSEASKTSGLSADGGSIIDTQAAVALSPSNTTPLHPSPISKMLSRGAVTPVSGYPVAMTSSGSGMLGGASLAQQSELVIVHQHIQDTVNKRISTLDYLRKAHEGRLYWFNTLLFDKPDLQRMSYFDPRKLGRRATNYLLLGISLPAVIDLNSSTPTDFLRSLNTLLTEFDAFQQIHTENGVAATSLTRARLPQMFRRAAAPVSKGRRSSSAAGRDTDMGIGYSLEQVDSNTPGVPAGINGGGGGPAPGVAVPGGPAGAAAAAASAPEGVMAFAASEVDLLPGEEYTYLLTPTLPFDPDFFETFATLCDVLIDTYSRLLSLLPTPRECGGSVADLFGKVDSRIRKLFIQGVVREFEEVSRAGVKAEVASVGKVVLSGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAR3</accession>
    <name>A0ABR3VAR3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="4">M1Pi</shortName>
            <shortName evidence="4">MTR-1-P isomerase</shortName>
            <ecNumber evidence="4">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRI1</name>
        <name evidence="5" type="ORF">VTJ49DRAFT_2206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000192">
        <property type="protein sequence ID" value="KAL1838813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="389" mass="42034" checksum="BA6E61238901C9C4" modified="2025-10-08" version="1">MATLQAIKYSPGKLLVLDQLRLPHEHHYDEVSTAEEAFDSIRSMRVRGAPAIAIVAALGLAVELSNGACTASTAEDTVTYIESRLDYLKESRPTAVDLSNAITKLKQAVRDANVEGLAPAEARQTVLDTYLAIAEQLLAKDLENNTAIGTFGAAWLQQQYGATPERPISVLTHCNTGSLATSGHGTALGIVRSLHAQNLLKHAYCTETRPYNQGSRLTAFELVFEGIPSTLITDSMAAALMRLRRGDMAIGAVIVGADRVVRNGDTANKIGTYALAVLARHHGIKFVVAAPTTSIDLETETGDGIVIEERKREELTQISGAVVNADGTVDPNRTARVATADQRINVWNPGFDVTPHELIDAIVTERGTVVKGADGRFDFSKVLPERWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB52</accession>
    <name>A0ABR3VB52_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000177">
        <property type="protein sequence ID" value="KAL1839070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="166" mass="18783" checksum="A33A88DC080581A8" modified="2025-10-08" version="1">MAQSTAHRRLLQEYRALTNNPPEGITAGPVSEDDLLHWEALIQGPEGTPFEGGVFPAELRFPKDYPLAPPTMKFLGEIFHPNVYPSGLVCISILHPPGDDPNHYEHASERWSPIQSVEKILISVMSMLAEPNDESPANVEAAKMWRERRDEYERKVREGVRRMLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBE2</accession>
    <name>A0ABR3VBE2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-L-rhamnosidase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000179">
        <property type="protein sequence ID" value="KAL1839031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF1">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46170" checksum="CED40C29013B05FE" modified="2025-10-08" version="1">MADSPSRPYHERSRTLSSASSRLRRFSQDFVDSRPPEGLMAVTGEVASSLFTHPHTPLDGNALATIESRPAGTRQPATADPEKKQLANGDEPRRTSDAITTTQVISSSDEATLSGPPPPSRTPTQAFPNGYHFPPKYPWHETVRHGLKSFWAFFITPMGFFWTIYGLNIVAWGGMLFLLLCNASPAMCYPTCDDIDSPRRKWIEWDAQILTALFCVTAFGLAPWRFRDLYYLLKYRVRGQHDALRRLAGIHNGWFRLRGTQDLPPDIGPDNVANAYPPVDPSLVPIPEKNMPQAPLTGTRAAPTAVWKLDLVIWSMVWNTFAQCALCGIMWGMNRHDRPSWATGFLVAIACVIAMVGGLVMFLEGRRVKSVEGVPLSDRDREKLARDKELGIPHYNNLKDKKPKEKKGAKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VBJ3</accession>
    <name>A0ABR3VBJ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000195">
        <property type="protein sequence ID" value="KAL1838756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14311">
        <property type="entry name" value="UBA_II_E2_UBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="235" mass="26090" checksum="9DCD821D4A064F7E" modified="2025-10-08" version="1">MATTRERRIAKELADINNDKDNSGVFANPVDPADLTHLKGSFIGPPDTPYAGGTFQVDIVIPDMYPFKSPTMRFDTKIWHPNVSSVTGAICLDTLGSGWSPVGTIKMALISLRMLLESPNPKDPQDAEVASMMMESPNEFAKKAHEWAVKYAGAPRRDNLTHNYEKAVPPPKKDDPSRYKGYNKDLVDRFVNMGFDVDAVVEAFIYVGIDRNGGEDYELEEAYMGDITARLLGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCS9</accession>
    <name>A0ABR3VCS9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052590">
        <property type="entry name" value="Stress/Virulence-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569:SF5">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 10 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9113" checksum="1F676FE2824617BE" modified="2025-10-08" version="1">MSGTQNTNPGNFANRPKEEVREIASKGGQSSHSGGFASMDPDKQREIASKGGHASSGSFEPGSERAREAGRKGGSRTGTSRMEEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD84</accession>
    <name>A0ABR3VD84_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000139">
        <property type="protein sequence ID" value="KAL1839828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33516" checksum="17D9E1A54BFDBE90" modified="2025-10-08" version="1">MATLTTTEGLIPNWFPPNRENYDRILFFWKLYPLFASLQWLTRWYGMGKTSVTSSRLNLPGRLAWFTMEIPGFLTLLYHVSSLSSQLPDNHEGLPYQNKVLTALFVLHYLYRAILYPILQPSMSPIHALVWILAVSFQLVNGLALGSWLGAYGPTTQAEWRWSAQAWGWGWGWGWSPGQFALGLAIFYVGLAGNYYHDEELREIRRRAGRRAAAAAAKDVSSKHNGGTSSEGSKKKKTSLVEKHYELPTAGLFRIVLYPHYLLEWIEWFGFWMAAGMDGLQSKHHIASLTPHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDM8</accession>
    <name>A0ABR3VDM8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000168">
        <property type="protein sequence ID" value="KAL1839236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="35"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="200" mass="22713" checksum="F4E0851F5E15C680" modified="2025-10-08" version="1">MTSLLTRILRPFTNSAVMTSSTTPALTIPEGAERATFAAGCFWGVEHAFRKHFSGKGLHDARVGYIGGDAENPSYRQVCTGTTGHAEATLLIFDPKQLPYRTLVEFFYRMHDPTTRDRQGPDRGPQYRSAIFFHTPEQEAVARDVTARASAQWWNNGIVTEILPAGKWWDAEEYHQLYLHKNPHGYECPSHFVRNFPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDP3</accession>
    <name>A0ABR3VDP3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000167">
        <property type="protein sequence ID" value="KAL1839251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="530" mass="57476" checksum="AF35FE2E1E6DCDD5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEB8</accession>
    <name>A0ABR3VEB8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000133">
        <property type="protein sequence ID" value="KAL1839965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="296" mass="33527" checksum="8B027DFA76B7E168" modified="2025-10-08" version="1">MVEVFSHNLTPLETPPSPFSSEDRRLGHPYPRGPKRTPRRSQTHHEYFLPSPLFTLFATPVPSPSPPTPENRLLAPSAPPSLPTAGGEQDPDRRRAPPRRPPLGPPRRSYSVTDKQPIPHRRQRHGQPNYDDTLSLMDLPAELHYSIMDFLDPIDSTCLGLTNKHFYAIHRRLRGTVPLTTRRDGPNDLEWAWHLAGNIVRKDPTSTSHGLDEKDKNALSKLRIRGQGYCRMCGVTRCQLHKHIQEWMGEGLEYCSVKQKFGPVAPEGAKSYCYMSKPGDKSKCGRHKGRSTVQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEH4</accession>
    <name>A0ABR3VEH4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="214" mass="23502" checksum="A426660875E7B82C" modified="2025-10-08" version="1">MASNTFTITAAPGTDIWRKPPTTDVFNAPTALPSPSSTNTTLRTTGPLTTFRSARLSFNFTPTAQYDQAGLLLSFRRRGTTTTTPPAKWIKTGVELYNTLPRLSTVACDNWADWSVADLHPATTKAGQEVGWTTVLVEKDKDGNGTGMWVYRLASNAETGEEEKVPLREICWVFGLEELDEWEVEVSAMAARPEKGVTEGLVAEFRGLEVAWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEN5</accession>
    <name>A0ABR3VEN5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000118">
        <property type="protein sequence ID" value="KAL1840324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="65"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="246" mass="27627" checksum="44579C436D5C97D1" modified="2025-10-08" version="1">MPPVYSDEEPSDTEVQPVKKATGRARKSTNYEEVTPDDDDAGSADEKNGDAGADDEGGDEDEEVYVVEKIMSHMIDPNGVPLFEVKWEGYEKKSDRTWEPEENLIENASEVLNEYLDSIGGREKLYKEAANVLKTKKRGRPPSSTPQATNKRSRRNGEHPADSEPPASAKAALWKPPAGSWEDHIAHIDVCEDEDKNALQVYLTWKNGQKTVHSTEVCKQRCPRRMCDYFLQHVRIVKKDPDGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VF63</accession>
    <name>A0ABR3VF63_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase T2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000115">
        <property type="protein sequence ID" value="KAL1840379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047208230" description="RNase T2-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="159" mass="17130" checksum="6ABADB6A4F9DC4D4" modified="2025-10-08" version="1">MRTQTITLSLLAALCSSVSALAFNGTGQLRTVYNRPPHDDLGCLTKDGKWTVDEPLCGVFTAVRTGNYNDYTLSAEGSGPCGIDHIYFTCGEGVTPRIFSTWGDNVPAPGLTVLRVGQYGVFATDAPDSPPPPGAEPLRIHFYSASEKGKYAWLGWKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFA5</accession>
    <name>A0ABR3VFA5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000133">
        <property type="protein sequence ID" value="KAL1839958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="115"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="240" mass="26379" checksum="12ABF7E8B6BF7062" modified="2025-10-08" version="1">MRPSMLSTARTGASLAMRARPTTALVPVPFRAAAAAQISSSSRTDAAHGSSQHSSVQPHGSSSYGLARLGPRKEVPLPSQEGTKGLVQYALTTLDIVANWARQSSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTSEALMYGIFQLQRKMRNTKITRMWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFE5</accession>
    <name>A0ABR3VFE5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="216" mass="24597" checksum="B8E2E8ED3EE03F91" modified="2025-10-08" version="1">MMRIAHFDSATFFFPSSFRDSFRSILTNPPCSVRLYQAPVESDLPSKPPLDRSARLRSNIRRALDRNEDRIRERRRRVLAAAMTTSSSDAGRRLVRSYVPEPPLLRSMGSSADPRSGSENGRRSLRDTNRRIGLDDHLVTIFGERWAHLHAESNPSPLRNDLESAHNLPMAVESAFLPRHREPRPEPTYALSSIRSTQASDHVSTTSLTESIWRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFJ8</accession>
    <name>A0ABR3VFJ8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000120">
        <property type="protein sequence ID" value="KAL1840287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046145744" evidence="2">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="247" mass="26269" checksum="27FFDB38FA5EA59B" modified="2025-10-08" version="1">MTRIFVTILAAAAALQQVVGAPIANPDPEDLEVATRTGRPPHPTLPLPPLPPRPTRTWTPRPPPKPTTTKAPPKPTTTKAPPKPTTTKAPPKPTTTKAPPKPTTTKAPPKPTTTKAPPKPTTTKAPPKPTTTKAPPKPTRTRVPPKPTTTKVPPKPTTTKAPPKPTTTKVPPKPTTTKAPPKPTTTKAPPKPTRTRVPPKPTTTKAPPKPTTTKVPPKPTSTSKKQTLTVPPRPTFTRHPPREIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGJ7</accession>
    <name>A0ABR3VGJ7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1840984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="443" mass="48578" checksum="966FD795371346C5" modified="2025-10-08" version="1">MDPSDILNIDDQLVTPDHPARTDLEGMDHARCAALHNYLVSYAWLAEGRLLSTLGENHTSFFTAHGAAAEALRPRLHPSITAFLDAVLVAPPPREGARHEDAPPPLFWFASGINYPDYLFDNDTADLHDEPPDTLVCLYFLPYGRSGSGVFYHQRLHRAAVFMDMWDHDFAMPAERHPELWYPLETVLSNWIELIRLGKVVAAPSDVPALYESEKMGPWEWRPYSEAQVDACVKAWDRLCAAIEAKLPLLPTPPPPRPSSQPLMTEAALKAAHIHSPSFAYSFLSRARRPTAFHRPAPGLVLPPTDPAIFASLQPFTPLFANARNQDGSVTTAEDFSTYPIPPVLLFPAAADRSESCPRPAAGPVAVGTTATAATIPHVDLSNPSSSHNPFFAFYNADSGRRITPSPHVPAGLYSEGVDRRDYDIVEEGFHLLLPESSAASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGZ6</accession>
    <name>A0ABR3VGZ6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="73" mass="7899" checksum="BDDD3DBDA7D906AF" modified="2025-10-08" version="1">MPSASRPGTPVIKKDPPQDDTSTPSTSSSGPTIVVEDTSKDKKLSIPSTAERAWTDSPSFTLQQSSVRIMSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH00</accession>
    <name>A0ABR3VH00_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Fe-S cluster assembly protein DRE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_7573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="12">
        <location>
            <begin position="233"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="10">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="310"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="35947" checksum="9D52095501BF0923" modified="2025-10-08" version="1">MPPALDLTPDFNPTMSAQPTTTTSSTSRTLLLAPPSLASREDRLSALFAVHPRASTDLHMLDRLAAGLVSLPPSTYDLVLVLTDPDGARRGEAAALLADRAVWSRLVPAIAPGGRFQGEVPGFGQDADSEKEAALRKEAVLAGLVVAAEGAEGFVKPEYAEEEVVPLKLGFGKKNNAVVTVTGNKKEEQKAPAPAGVGFVDFSDDLDLDAEDDDNVIDEDTLLTEEDMRRPIQQPPECAPQPGKKRRACKDCTCGLAARLEAEEKARRAKADSELNALKLKSEELTELDFTVQGKTGSCGSCYLGDAFRCSDCPYIGLPPFKPGEEVKILNNTVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH59</accession>
    <name>A0ABR3VH59_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000085">
        <property type="protein sequence ID" value="KAL1841145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="931"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1321"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="1410"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1167"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1185"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1541" mass="168937" checksum="39210AA78D409E59" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHA8</accession>
    <name>A0ABR3VHA8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000098">
        <property type="protein sequence ID" value="KAL1840806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="50077" checksum="701915A5C20AFDEB" modified="2025-10-08" version="1">MFHHMDTNTTFVSPSTSNFTYNPDEIVGWNPSDTNRGSIEILWSCSVTIILCCWVCPLPNVPSLNDKWYHTLIGRFNLACIGLIGPDYLFGIALGQFSSARRSVKLFQSLSRIPQGREWTLTHGFFADMGGFILVSPDYPPFPINAEQLHYLVHHGHVDFPTITKADIKALNKMDGMSKLITLWQVFWFTTTELQRVSRGLPMTVFELTALSFSLTMLVTSVCWYAKPTISKPITLLTREGRSVESIRAAARETTHPNLPQTWYRTPLDFISPYRRFRLDVHWCYYEQLTYLLRLPLFSREITSRPWDRLPSKAFLVIDRALLPLAFAVLVAYSAAPLFAWNFHFPTEGERLAWRACGVYHAVFSMGLGMYYIITAWKVQGKAGKLDEPPFPVKGVQHVKGAGCDDGSGGGDQSGVDVEAVEVVGDKKGNGHSVVIFKHLKLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHY3</accession>
    <name>A0ABR3VHY3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000073">
        <property type="protein sequence ID" value="KAL1841500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046106554" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="134" mass="14753" checksum="C2C3B914935C832D" modified="2025-10-08" version="1">MRLVPRLSLAVGLLALGGSSVASQQADQMQEFARTCAYDESTLTDGHHWLRTACLHDMMAVSGYDETCGKYSTSCPKCLLDKEWRLKTMMLKCSCHDSRGTLHTSELDLNTAIQNIHGALACFDHVGNKTVPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI40</accession>
    <name>A0ABR3VI40_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021216">
        <property type="entry name" value="DUF2722"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10846">
        <property type="entry name" value="DUF2722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="534" mass="56169" checksum="D37FFA09A65938FF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI41</accession>
    <name>A0ABR3VI41_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF34">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G07820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="154"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="353" mass="39175" checksum="8395D03C37CB53F5" modified="2025-10-08" version="1">MKITGVYVYPIKALRGIKLESAHVGPQGIRHDRRFMLYEVRPGTNDRRKIQLDTHPRCALFEQAFLRGDDEHGEESAVSVHFLGEEGQEKADDGEGDETIHVPLTPDITSLAKIDVDLHGSPAKAYRMGDVYDDWFSKRLGIRTMLVYIGDGRRAVLGKTLPPKPTQTQQGGWISSLVSYVTRTQDPAGDSTPWLAFSDVAPLLVTSEASLRDVRDRLLGGHPVEMYKFRPNIVVDGEGEGPWAEDFWAELAISGSTDNDDNDDNDDGTGERHRENVLQLTGNCVRCTSLNVDYRTGNPGEGEEGSVLKRLMKDRRVDAGSKWSPVFGRRVPLITGYFKAMLAIGRYCLGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI74</accession>
    <name>A0ABR3VI74_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="8">
        <location>
            <begin position="367"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="527" mass="59793" checksum="51BC2A234C77CD58" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIF6</accession>
    <name>A0ABR3VIF6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000073">
        <property type="protein sequence ID" value="KAL1841507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="124" mass="13245" checksum="3D585B9B51BE8E26" modified="2025-10-08" version="1">MSATPVFTKNAAPPAGPYSQAIKTPTAIYCSGQIPCDAEGNLIEGTIQQKTAQCIANLKAVLEEAGSSLDKVVKVNAFLTDMANFADMNEEYAKWFTHKPARSCVAVKQLPKGVDVEIECIALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIF9</accession>
    <name>A0ABR3VIF9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="522" mass="59136" checksum="DF54CC377ECFE8EC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIU3</accession>
    <name>A0ABR3VIU3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="351"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="596" mass="63843" checksum="4FAD2D203E2FBE7A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIY0</accession>
    <name>A0ABR3VIY0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="244" mass="26312" checksum="C12EEC31A0463BBB" modified="2025-10-08" version="1">MQPAPPLPPPPPPVSLPNAPPPSTSTTHQPSHTPQSILTPNIPPTGPPNTVLLSLLIYNGYPFCDHWEYFVSAPASAPEPSIAPSVDASHASDIGTVLQAKGNVREGFVLEVKRGWDISQPGQRPDRVVRLGWVDRGLLEPVGEVLFGEGLGCSDERVKTGSDGGRTPVIEENCEARCGFEKIVFRVPAPGKTLRDAEVDGVERRARITQRNCQTWIIETAVLLAGEGVLEHGIVEYLKATKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJK7</accession>
    <name>A0ABR3VJK7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="6">
        <location>
            <begin position="170"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="288" mass="30843" checksum="0E77B5F885CC27EC" modified="2025-10-08" version="1">MTPASYGGYQRTGYGAQGGEDGGGFMSGSQQPQNSQNNERGGPFKNDPLRPVTIKQIIDCKEAYPGAELAIDGHPLKQITIVGQVRSVTAQSLNLTYRIDDGTGLIEAKKWFINGQTADDVPSYAPNTYVRIFGRLQTFNDKRHLGIVAMRAIDDFNEVNYHLLEVTYIHLFLTKGGSLTGAAAGVQHDGGSTAMDTSGGDSMFVDNGYGAGNDPQAAALARLGPVSRNARAVYKYLVTLQGDAAHVSVVKRNTGLSETDVMAGAGELLENGLIYTTEDDETWAVLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJM8</accession>
    <name>A0ABR3VJM8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000066">
        <property type="protein sequence ID" value="KAL1841706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="69"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="691" mass="75979" checksum="9B4C7CDC94CCFA6B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJW5</accession>
    <name>A0ABR3VJW5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol phoshorylceramide synthase regulatory subunit kei1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000053">
        <property type="protein sequence ID" value="KAL1842127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="27582" checksum="25A00B821296AB76" modified="2025-10-08" version="1">MSVTSPLSWLRVPRPKSFLGFISLQTGTELVSIALLINKATGIYGLLTLFTGYALSALQVTAYLGSVFVLATLAVCIPQVRRRSPLHCLILAWVYAIDTVVSTAYTAAFATSWYVAGVHAVKAPSTSAEDDGSAAGNARRADATPSADSDANAPDTAFSIGLVVAFTLIRFYFSLVVMAYARMVILRYVDERMGDTEEAPDTAADPFAPGAPLGEGWKGRLGRVLLSVGRGYWLGGKKEDEEWARQVNSKFRSSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK59</accession>
    <name>A0ABR3VK59_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72429" checksum="8589325BF811E6B1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKA4</accession>
    <name>A0ABR3VKA4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000046">
        <property type="protein sequence ID" value="KAL1842325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36492" checksum="89B445BDB937FA0D" modified="2025-10-08" version="1">MSTTVQASELRNVYNPSSKKTADNAWEETWIENSRRVSTPLAAQMLEQMGISASTTAPFRLLENACGAGVVAPFLQRIIQPDVLRQSSIVCGDFSDKMVGLAEGRIQREGWINTKALRVDAQKLDFEDDTFTHVATNLGFHVVPDSEAALDEAMRVLQPGGILGFTTFHCHPSWFRDVKAAFQSFPFEAPCSMELQTTSWGQWSDINWVRETLVNKGLCNVKVSVFAHLSDVDGPEDFITRYGMMVDWIVDSCWSEELRREYPREVVHRMVKEFLEKRRDVANDLALAYATQDQLYALFLLVAWENHDYMHGNGAPLYSPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKF5</accession>
    <name>A0ABR3VKF5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_5669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="25046" checksum="EC9E2DF6FBAEBC0E" modified="2025-10-08" version="1">MVSLPLFKLAALFVRHVSKYGANHIKKQAHEHERFRAFAERYGQHIHQINMRLQVAVLRNQVAEQRAKEKAEAPTVKTEEQVKKEEELRAKYGTTPLESHPTADVPQSVWKRKFRPLPEAKAVDLFADVIGDAFILAVAGALVTYEYWRSSQKPDKNLQLIEELQRRTEELRIKEEELEAREKEHEERVRNIEEALRAFKDPKTKQPLLPPATATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKN0</accession>
    <name>A0ABR3VKN0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30276" checksum="F0A3B56669656D37" modified="2025-10-08" version="1">MLPPDDSPTRDSSIAEGMTNPKSEKAPSLFSRAWVYLNQDVRASGLAELELLILTFCIGLQDAVSFPDFHCFASNQTGNTVFLVLAIVLPEADGDMFVTANIGVALGFFLLAAMLTGQLGHRVGPRRRGWLILCNLIQTCLVFAAAAMQHIQHRRHPWPPEGKTSAATLWAIGLLASAAGGQVVQSRALRMTEITTAMATAAWVDLLIDPALLAHPVKNRPRNRRLGFLAALLLGTLAGAFVFKRLGSPAALMVSAAGKVLVAGMFLLNPAEREKGEEGVGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKQ7</accession>
    <name>A0ABR3VKQ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="245" mass="28383" checksum="20816B64CD344515" modified="2025-10-08" version="1">MATTDAKDESVDTRDAVEVLEAEAKEFEKDAEIDRILKAFRLDAYAVLGLKPGVPESDIKLAYRKKSLLIHPDKTKNPLAPEAFDRLKKAQTELMDEKHRATLDEAIADARMLVLREKKWTVDSPELKTPEFERLWADKTKFVLIENEQRRRRQLRAQMQEEGREQRRQEEEAEARRRKRQHEEEWEATRDQRINSWRQFQKSKTGGSSGDGGPSKKKKKLKPIGFCLSIATLRPDVTQGSVRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKR5</accession>
    <name>A0ABR3VKR5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_6992</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000073">
        <property type="protein sequence ID" value="KAL1841501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
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    </feature>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
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            <dbReference type="EMBL" id="KAL1841501.1"/>
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    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1922" mass="211200" checksum="A46703879CE4BEA1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKY2</accession>
    <name>A0ABR3VKY2_HUMIN</name>
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        <recommendedName>
            <fullName evidence="8">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_5365</name>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
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        <location>
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            <end position="631"/>
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    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
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    </feature>
    <feature type="repeat" description="TPR" evidence="3">
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            <end position="870"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1269"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1269" mass="143990" checksum="70D7B1519430175E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL99</accession>
    <name>A0ABR3VL99_HUMIN</name>
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        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">VTJ49DRAFT_5017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
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        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1842541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF812">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="394" mass="43886" checksum="A40512C1C088CEA9" modified="2025-10-08" version="1">MSFTSIPILDLSLAKDPATKPEFLKELRHALMEVGFLYLKNVGISDETFQRVIEEGVAFFDIPEEEKLKIEMKNAPSFLGYSRLAAEITAGAIDHREQIDLSTEHPPAPEGAPIYYNLLGPNQWPSPEVLPRFREVFTDYMKRMGEISIYFTSLIAEAIELPSDAFNKYFDADQQHKLKIVKYPDVGQLGEQGKSRQGVGTHKDSMLSSYLLQASHHRGLQVQNMRGEWIDCPPIRGTLVVAIGQGLEALTQGVCVSTTHRVLSPAAGEGPRFSIPFFQGVRLDADFDELETVGVGKVPEHVREERRRVAEKNGGRIDDVEFTFRKGGVATTLGEATFRNRVKSHPDVAERWYPEILESVREEQARLAEKKTVTVTGVGGELESSVAPPAVQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLH6</accession>
    <name>A0ABR3VLH6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="10">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5716</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="414" mass="46517" checksum="737FF6EFB891FDC7" modified="2025-10-08" version="1">MMRPLLRRCAPRAAAFVAPRRPASAFFVQAARQYSVKADVASETKLQDIDPSQLVIQKTTNPKPLKQAKDLIFGRNFTDHMLTIEWNKESGWQKPHIVPYQNLSLDPATCVFHYAFECFEGMKAYKDKAGQIRLFRPDKNMERFNKSAARIALPNFNSTALIDLIAQFTRLESRFIPEERGYSLYLRPTMIGTQKTLGVGPPGSALLFVIASPVGPYYPTGFKAVSLEATDYAVRAWPGGVGDKKLGANYAPCIVPQKEAMSRGFQQNLWLFGEDEFVTEVGTMNFFVAMRNKETGQKELLTAPLDGTILEGVTRDSVLSLARERLAPEGWNIVERKFTMRELDEAAQDGRLIEAFGSGTAAIVSPVRSISWRGKMVHCGLKDHEESGEIATKMKNWIEARQYGDDEHEWSYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLM6</accession>
    <name>A0ABR3VLM6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="178" mass="19014" checksum="CFD017DAB2E92DEE" modified="2025-10-08" version="1">MTSNPPDKPSPDAMDIDQQPTTTEPTNKPHKRNRPAPRRPPTTTLTLRSPPFAYAHLQLVTPPTSTEAPNPAVSEQPALLDNLQLRSYLTAALRQFLGDTGAAIPLDILLLRGASAWVRVPREDLAAFAAAVTAFEGLASGNDPSSDPAGLMLLRVMACGDWLGALVGRDEEGVLWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLQ7</accession>
    <name>A0ABR3VLQ7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">VTJ49DRAFT_4470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="909"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1091" mass="117190" checksum="1A7ED9B28E6623EC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM74</accession>
    <name>A0ABR3VM74_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="184" mass="20511" checksum="0C40058070B0853C" modified="2025-10-08" version="1">MLLVLPLLDLHPHASVLPVALSLIAFSSLAFSPLATPAWTPSPSAAANLSSSSPAAFEASRAPPAYPVRAHKRWPRMVELFITMFYPRRAQGRLYLHLTKAARRMEATSRGVVGWEVGNWGEYEPRGFSLAVRFKDMTALDDNRELIRDMLAEGLEQELFLETPEVSLARGRGLFALWDYEVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMG6</accession>
    <name>A0ABR3VMG6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="58"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23921" checksum="3EF08C96C417F127" modified="2025-10-08" version="1">MNRLFGTTGPKQPKPTLNSAISNIDARISAIDVKLASINAELQGYQSKLSKMRDGPGKTALKQKALKVLQRRKQYEAQRDQLQSQVWNMEQAQTMQDNLKNTMATVDALRSTNKALKKEYGKVDLDKIERLQDEMADLLDVGNEIQETLARSYDIPEDVDEAELDAELEALGQEVELEREMAGTEGALPSFLQDEVPEFVDEPPVTTGKVKEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMK3</accession>
    <name>A0ABR3VMK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000031">
        <property type="protein sequence ID" value="KAL1842837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045201989" description="Glycoside hydrolase family 5 domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="75"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="432" mass="48843" checksum="F68A8D68C1BA2A97" modified="2025-10-08" version="1">MAHLRLLFQHYLLTLLFLTPLLTSAADTNQTLPALPLHTTSRWILDATGARIKLRCINWAGHMETHLPEGLQHQSVDFLTTWIAQQGFNCVRLTYSTDFALDPGRTINRAFSAAAAPAGVSAADMEGLRKMVVARNPWIDPDKTTTWDVFATVVDLLADKGIMTILDNHVSRAGWCCNLEDGNGWWDAGFGYNHWNSRYFKTGEWLTGLQAVAAWAKGRKGVVGMSLRNEVREFLLQGTFNKREDWYRYMKEAGDLVHATNPDVLVIVGGTQSSTDFLHLRTGDKRMLDTSGWKGKHVWEMHAYSFTVTFPDPFQNCDMVKAQYGLFGGFVLEQGKEYTGPLFLSEFGVGMEGGPMDGLNEKDDRYLKCLVSWLESNDADWAIWAIQGSYYARDKRADADETWGLMNHNFSGWRNPAFPAMLKNMWNMTQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMM5</accession>
    <name>A0ABR3VMM5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050592">
        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642">
        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642:SF139">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045130959" description="CBM1 domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="7">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1842953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="548" mass="58689" checksum="680B96ED010649AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMZ9</accession>
    <name>A0ABR3VMZ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cerato-platanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000033">
        <property type="protein sequence ID" value="KAL1842785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046192419" description="Cerato-platanin" evidence="4">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14755" checksum="82088C6C34667FB3" modified="2025-10-08" version="1">MRLSTIFNISSLLAAVSATQVSYDLGYDDAGRSLNVVSCSDGNNGLITRFGWQTQGQIPAFPYIGGAQAVGGWNSPNCGTCWAATYNGRTVHILAIDSASNGLNIGLRAMNDLTNGRAVELGRINADVRQVSLESCGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN54</accession>
    <name>A0ABR3VN54_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031558">
        <property type="entry name" value="Vps36-NZF-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16988">
        <property type="entry name" value="Vps36-NZF-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1843077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="641" mass="69515" checksum="941EE629B6B651D1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNA4</accession>
    <name>A0ABR3VNA4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37099" checksum="5C614C7C6167492F" modified="2025-10-08" version="1">MSTTPETAEVSAAPVKPNVDNGDGVKRHEKKPVPEQEEQEHKPDQEQHEQDPTAAQDSETQTSAVNRSKSSPSPSPSRSEGEYSGSDTSDHPHAGEAADTTTVPANPPLPDEPLPDDAPDSTAPPLPNEPLPDDAPPLPDEPVPAEPQEDDGWEYHWNPNDQSYWFYNRFTGVWQKENPRIPTADATTTTTAAAPAPEGSAAPGEPTTVLSNPTSLAGGYNPAIHGDYDENAWYAQNLRAATAPSVSTTGEAYATAAFFNRHTGQWQAPDMGAERHSDEAKARRQMRAFFDVDAAANMHDGRSLKAERAGIKPTKAELKVFKERRRQRKEEKRRAWLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNH8</accession>
    <name>A0ABR3VNH8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="262" mass="28226" checksum="62C1E6A20CB39278" modified="2025-10-08" version="1">MSMREIFVVFAGLASHVSSRRGRQSGGQMITHIVDLSVPGGHVLPAPFANRSLPFHTDPAADILAMFVVQPSLSGGHGFFSPVATVYNKLVTHRPDLLHELAAPNWPFAGPGAGHQAVIRRPVMFLGPASGAPEMLFSRGALIRSASSAASMPCLTPAQNAALDAVHFAARDAACRVEYTAGDVLFVNNRRVLHGRESFHDGPQLSGSSSGGLKRHMLRLWLQDEEYAGIPPAPIADVWATRFADHDHKEHDEGWPLQPNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNH9</accession>
    <name>A0ABR3VNH9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RraA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF28">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23302" checksum="A7C04406CDD8ABDC" modified="2025-10-08" version="1">MSTTTTPFKDPIVEALRQYTTCDVADALVKLGIPDGGFLPGITMWSPQRQDGDTKIVGPAYTVVYAPHDDPRPKWPSHYIDAVPAGAVVFVTSAGGSASNALYGGLMSTRAKASGAVGSVINGRFRDLQEQRELGYPIFARDVGTAPPGPVLKVVDVNSAPIEGLCSIEIAPGDYVIGDVNGVVVLPRALAEKALPLMEKQVEADSKMAAEIAKGMSFAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNL8</accession>
    <name>A0ABR3VNL8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_4834</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4"/>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="11">
        <location>
            <begin position="138"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="12">
        <location>
            <begin position="330"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1842551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="406" mass="43794" checksum="AEC7D2D905B1BAB2" modified="2025-10-08" version="1">MAGMWDPAPSTRKSSDSGTPDSGPATNFRPDDSDVGSKMATAKNQGKAAEATQHPDLCSLPARYPSLPIPSAPCAQEPTMDLVNHLEGRLLFAVPKKGRLLQASLNLLEGADIQFKRENRLDIALVKNLPIALIFLPAADIPTFVGEGRVDLGITGYDQVQEHDAGVRALARARRMSNEWDGKPRGCETIMDLGFGSCKLQVQVPAKGEYTESKHLVGKNIGTSFVHLARDFFARLEMEQEGITDPKQMEGRKLRTKIIELSGSVEAACALGVADGIVDLVESGETMKAAGLKAIDTVLETSAILIKSKAPSNPELVDLIASRIRGVITAQRFVLCQYNVPRDRLAAATAFTPGKRAPTVTSLDEEGWVAVSAMVEKKRIAPVMDDLLKVGAEDILVLDIQNTRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP23</accession>
    <name>A0ABR3VP23_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="73"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="397" mass="43890" checksum="EBF2BA50DB2355CF" modified="2025-10-08" version="1">MASSSTQHVEVTGLFFPAQECPSRGVSEHRKRHHRRHDDGLHSVRFFATDKPSRLIVDNISASREEPAVTVKLGQLGADDYMCVVGLLAIYGTGIAIAHMTKYGLGRHVYAMAPTDIPLYMRDFYVSIVMYCSALLFLKMTFLLQYYRVLAVAHMRTVYLVSMFIVGGWALSQVMVGIFTCTPVSGFWDFTIESKCIPNQPQWYINAAGNIITDVAVFCLPLPAILKLHLARGSKLILLGIFCLGFFTVIISGIRIRYLKVTEDFSWWNIEPSLWSCIELTSALTCACLPTLRPLLTRVFPSLGSQSTISGGGPPALESQVGRTHHDRKALEDSAESTNRSDVELTPTSPVAADGLRANPFEVHVVHEVSMGVERGSAWPNGQLGVRGYVEKPAWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP49</accession>
    <name>A0ABR3VP49_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF17">
        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="309"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1843687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="575" mass="62013" checksum="FCE40C6953842888" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPQ7</accession>
    <name>A0ABR3VPQ7_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_1137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000014">
        <property type="protein sequence ID" value="KAL1843544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="586"/>
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        <location>
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            <begin position="1168"/>
            <end position="1178"/>
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        <location>
            <begin position="1202"/>
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        <location>
            <begin position="1294"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1328"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1843544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1343" mass="146278" checksum="413F29D6AC6A6296" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPW6</accession>
    <name>A0ABR3VPW6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR038656">
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    </dbReference>
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        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCYTLDPTASE"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="288"/>
        </location>
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        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31246" checksum="CB4D6A25B39C1F1C" modified="2025-10-08" version="1">MRWFGRALLLASLAVSTVTAELSFTASMKQDGKEVDVSKLDFRRVPPLRHGRRRAHGGRGGRGGQRGDQPAARDLISYSSNWCGASQHTTQNDGISNVVGYFQVPDLTLRPGAPPPQFAAAWVGIDGAECNTTLLQAGVTTVVNSNGGQSAYAWWEWYPEAAFSIDSLRVKPGEWLSVDITASSPTSGIIVIHNLDRGTSITLHITNGPKLCRLDAEWIVEDFYDGDQQVNFGKFTDMWFVDVAAKTVSGKNIGIDGAAMVHLLDDSGKTLCSAEPYDNANFIVMSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPZ9</accession>
    <name>A0ABR3VPZ9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="70" mass="7859" checksum="6BF9160B70D7FCCF" modified="2025-10-08" version="1">MYRLGRSRALASAFAVPKASPSPRIQSIAQQQRRALSIHEYRSADLLRQVRLRPDEDQEGEKSAEAGHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQS6</accession>
    <name>A0ABR3VQS6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="390" mass="42566" checksum="B77571A2E761F71A" modified="2025-10-08" version="1">MAHLPPNAAIFSPSVARAAASTAKDWSFVDAWLQRKFPGRGPPPFERNQDTLRVLLALASANEAADEERALLARLESATLDQLRAREQQGEDEDDELDRSRRQSTGLGSIATASSDDEDVLGSARDAILTALEEALTREGQIALTAMASLALQIGHPFPTASALGAELASLSAQSMALEQAVSRVEALAAYIEREAAATARLAAELSPPSPHRHHDDDDDSFDGSDDQEHTIHSINPRTPIKQPPGTPKPPKTPRQPAGYHPPSDLSIQNLSLQRHIKTLSTRIPELRDRAAALARSFTTTIPTNTAGTGPSPTIQEVRALEEAYLELLSQKRTLDTKLREFAGLPPDAGRARQELEALRGELRRVTERRDEVFEGLVERESPRRVRKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQX0</accession>
    <name>A0ABR3VQX0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000005">
        <property type="protein sequence ID" value="KAL1844037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="155"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="416"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1844037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="583" mass="64307" checksum="EAB3D68DF4902563" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRF7</accession>
    <name>A0ABR3VRF7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1844309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14261" checksum="C3FF39F85D0B7BA9" modified="2025-10-08" version="1">MASQPAAAKRQQDLQLQYTTYKNTLQQLAQKIGDVEQEAEEHKLVLETLEPLPGDRKCFRMINGVLVERTVQDVIPALRTNAEGLKKVLDDLVKQYKLKQDELDKWKVSRNPPHMHRSSTRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0Z2</accession>
    <name>A0ABR3V0Z2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000693">
        <property type="protein sequence ID" value="KAL1835387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="73"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="503" mass="54395" checksum="F188B9EB5A9F4AC7" modified="2025-10-08" version="1">MSTTTTRPSRPATASDFIPDGDANGSSKKPINLLRGWPAPSLLPAAQLRAAANQVLADPVVAVPMLQYAIDPGFQPLRDELARWLGEVYPVYGNSAFTADEIAITGGASQGLACLLQSFTDPVYTRAVWVVAPCYFMACPIFEDAGFRGKLRAVPEDEGGIDLGALERGLKEEGGKEMETPPPPALKHPYPSRKLYRHVIYLVATCANPSGKTLSLPRREALVHLARKYDALIISDDVYDFLQWSVTPVTSSSSSSSTPTPLPLPSGTPLPLLSQIDNLLPPSPHNPPGKNFGHAVSNASFSKLVGPGTRTGWIHATADFAWGFSQTGSNRSGGAASQFAAAVIWRVLRDGALEGWVKGVVRPALRRRHVLMLREVRSVLEPLGVGVWRGREAGGVAEEEVYGGYFVWLTLPEGVDASVAAERARREEALVVAPGKLFEVVGDEDSARFPRNVRLSFSWVDEDEIVEGVRRFGAVIKRMLEEGGGEWRINTGTADEDSVAEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1K4</accession>
    <name>A0ABR3V1K4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000573">
        <property type="protein sequence ID" value="KAL1835663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="727" mass="79402" checksum="E65AA96A43C6A199" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V210</accession>
    <name>A0ABR3V210_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000534">
        <property type="protein sequence ID" value="KAL1835799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1835799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="109" mass="12819" checksum="9BCDCF9567647A4E" modified="2025-10-08" version="1">MCNFLEYKDTKIVYRRYASLFFIAGCGSEDNELITLEIIHRYVEQMDKYYGNVCELDIIFSFTKAYYILDELLLAGELQESSKKNVLRCISQQDALEDMEVEDEVTKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V295</accession>
    <name>A0ABR3V295_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000553">
        <property type="protein sequence ID" value="KAL1835727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="299" mass="34040" checksum="DBE1B56ECD29778D" modified="2025-10-08" version="1">MSKFGVIVMGPAGSGKTTFCQSLITHLRLNRRSAFYVNLDPAAEHFEHQPDLDIKDLISVEDVMDELRYGPNGALVYCFEYLMDNLDFLAEGLDSLTDEYLIIFDMPGQIELYTHCPYLPRLVKFLTQPGALDIRLCATYLLESTFVIDRPKYFAGSLSAMSAMLLLDIPHLNVLSKMDLIRPQMSKREFKQFLVPDTTLLDDPRRKKKTSVSVDVHSSDPRDKDALMSGATFQRLNAAVANLLETFSMVSYLKLECTEEDEGESIDAILSHIDHCIQYHEAQEPRELPDEEFEEPQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2B1</accession>
    <name>A0ABR3V2B1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAD50-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000527">
        <property type="protein sequence ID" value="KAL1835839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53875" checksum="C4022390E48173B7" modified="2025-10-08" version="1">MEHDVRVQDYLDDKLQSTADLEQLDTLLSSVEFQRSQLQSQLDDASRELDAARRSSADRAADLVARIDEFHALQRSIDERLEQVSRSNAPDQVIRRLEPKMAQLRRIDLAHRYLLLLRDVDDLSRAARSHLPHDPQAALEPYSRLKQLAARLRDLQRHADGAAVHLVAHVDALTTRLWDDMKDIMRTEFDALLTARGWPNVEPDTSVDDEWLRCFEKLVDLQAPEVLYSSEPVTLLPIDVMAAIFVKEFRYHFLSDKPTSSPQGIAAHCFPWFLSLLGKWEDFLRDNFGPILAAKFAGTPAARRMVYMDPVCALISSMLPVMREKLTTTLAETSGDPVFLSSLLSQLMTFDDRLRIDFTYDGGDPDGGWDGLTSEVLATHFRTWLEAEKTFALERFRAIMTAQDARQIDYDFAGPGRTKPTFAAVRVADLLRSVTAQYERVRRFSHKLRFLIDIQVTILDEYHDSLRGAVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2P1</accession>
    <name>A0ABR3V2P1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000520">
        <property type="protein sequence ID" value="KAL1835870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="190" mass="21177" checksum="DAFA10C5C86FA89A" modified="2025-10-08" version="1">MVNTDMTNLTLHTGSVDHTPVQDEVFRPCVTAGAPPPGPFPTVAAFHDYFVTMAATLSHTRNYGHHRQHYASSSYHQPPFSPPVPPPHLFPADVPVVFTHGALHPRNIIVTPGPNPRIVAIVGWEQAGWLPAYWELCKARWECARRGRLGGGWEAKYLPWILDAEGLGANLREWSVGALCQYWDYFVGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3A9</accession>
    <name>A0ABR3V3A9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000436">
        <property type="protein sequence ID" value="KAL1836279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="200" mass="20317" checksum="EE60CD55790C537D" modified="2025-10-08" version="1">MSGPSPDSGPGGFGTGAADQRGYHQYNNTYYYAFHPPQTASGDRANTHANGATITTTTRNVAYTPPDVIPARRPVQVQGLDGGRPAAPAVITTTAAPAPSDPSTVSPILPDPPQQQHGYLHPTHSSMSSGSGGGGGGWGGQQPQRMGTVSSAGVFTVSPASSIHDGIDSDNNADEEAYGCSGNSTSISSTNSTGKRPGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3T2</accession>
    <name>A0ABR3V3T2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_5637</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000475">
        <property type="protein sequence ID" value="KAL1836041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000371">
        <property type="protein sequence ID" value="KAL1836745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1118" mass="123865" checksum="D3E121423B204BE9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4S8</accession>
    <name>A0ABR3V4S8_HUMIN</name>
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000408">
        <property type="protein sequence ID" value="KAL1836456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
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        <property type="entry name" value="RNI-like"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="1000"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="84"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
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            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1026" mass="111475" checksum="356F8F6327DCFDE7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4U0</accession>
    <name>A0ABR3V4U0_HUMIN</name>
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        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">VTJ49DRAFT_4639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000365">
        <property type="protein sequence ID" value="KAL1836797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome_P450_fung"/>
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        <property type="entry name" value="CYTOCHROME P450 98A3"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="67757" checksum="CD6DED5AFD5FAA05" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Y2</accession>
    <name>A0ABR3V4Y2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynamin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
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        <lineage>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Lipzen A."/>
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</entry>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000394">
        <property type="protein sequence ID" value="KAL1836581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045988346" evidence="1">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="187" mass="20190" checksum="9000638CAC2484C4" modified="2025-10-08" version="1">MRFSIFVTLAALGVSTACNFISGGNSLAKTIMCFSLKALAVNKTAEALGKDGYGPWEEIITGLNDISSAIETAVNATLTAPLSTKYTGTDALNVAAAYFYWGSVVIELMKRLTDKAGDVDNCEDIKRHMAWALSDLGLVEEMLSFGLHDMVDEEEANATIRRTHNEIQRIEDAAVLMDRGGVTGMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5B2</accession>
    <name>A0ABR3V5B2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000369">
        <property type="protein sequence ID" value="KAL1836762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="209"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="6">
        <location>
            <begin position="417"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="620"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="76423" checksum="F22BF5995E21ABCF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5K4</accession>
    <name>A0ABR3V5K4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000376">
        <property type="protein sequence ID" value="KAL1836701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1105"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1132"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="10">
        <location>
            <begin position="831"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="628"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1161"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1206" mass="132345" checksum="B22C97A14B7942A8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Q8</accession>
    <name>A0ABR3V5Q8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin class II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
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</entry>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000283">
        <property type="protein sequence ID" value="KAL1837557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="196"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="580"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="580" mass="61651" checksum="1E46B6E02E3B8088" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V817</accession>
    <name>A0ABR3V817_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_3504</name>
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    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Mycothermus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000270">
        <property type="protein sequence ID" value="KAL1837707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
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    </dbReference>
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        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045483854" evidence="1">
        <location>
            <begin position="21"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="344" mass="35557" checksum="0128CF809C854F60" modified="2025-10-08" version="1">MRLARPILLLLSGGPLTALAATLTTIFTVPGPTLPGSWFENLAVRPNGKILATRGDAPEIWQIDPASGSGSLLVNVTGAYNLTGIAEVRRPFWHRRDGGGKGGKGKDRRHPHETYIFGSSHIPAPFTVTPGSAKVWKLTFGHSGTPTVSLLAAMPSAGFINGVAAWDAGRVLLSDTELECVYLMDTDTGSYTTPLTGLAGINGIQTRFSATGAGHGGHQYVYRADHLLSELSRIPVDADAVATGPAEVLATGTAIDDFAIKVDGTGYGKAYIAAMYDNKVVEVDVAAAPSSGLGTSTLLANDLTGTGVGLVTVVAFGRRSTDSNVLYATAGQGGGNAAIVKIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V864</accession>
    <name>A0ABR3V864_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000253">
        <property type="protein sequence ID" value="KAL1837907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047210695" evidence="3">
        <location>
            <begin position="27"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="208"/>
        </location>
    </feature>
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            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="441" mass="45950" checksum="0670C34CC43978D8" modified="2025-10-08" version="1">MAGARSFLANLFFLSTLLISVSVVSGNENCLDRNGDPDLKAARCWHPEFGATGLCCHVGDLCVVPGFCITPTDKPVEPFKHYPGTCVNGKWDNPNCTQWCANWRADDVFFDVCQDRDDPKKYHWFCKRGTWDRDRTADTCDEKAEIVVLPKFIDDYATAGVSPTSTETFSGDDDETTTATETSGTTTTSLPATPTEGTDNNNDDDDNPSSNIAVPIGIGIAIGSTLLLATSALLFFYIRKKRRSAPRRAETPPAMDPRFVNSQAPDWIGPVYGQQQPKDGPAELGDESVVVGRGVGELDGSPVMAHGQRGMMPGGPLGSSPVDMRSPVPGGRLGSPVSVQSEMADGPVGSSPVVAGHDGALGVAPYGGMCGGMPGVAPGGVPGFAHGVLQSGSVHGGPPRTPSAGSMQGGMPAAGVRPSLVPGGGRVASGEIPMPSLPELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8M2</accession>
    <name>A0ABR3V8M2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000234">
        <property type="protein sequence ID" value="KAL1838155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="121"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="357" mass="37977" checksum="E9E07ABCC559B5DE" modified="2025-10-08" version="1">MIGPRVLVGSAAKRAPRRNLHHATAVPILAARRPVINSAPSAGPISHRGRFHANASNSRHLLHTTSQSAREAQKQQPSQPNRPRRPRTFHLTPPQPPSIHPHSSTEPTATLPLSEQLRTVMRLLTHPVVVCTSTHPGTGNSTTTATPHSTSSSSSSFLPSHPTARAMTMSSFTSLALSPTPLVSFNIAVPSRTLDAVAASKRFNVHVLADDASGARLADWFAGGNADPETDSDLDSTVNVDATSTGPRGKMGVFERLVKEGAVRVVNGLESSDSSAEAAAAPILEGDGVLYVLRCRLLEDGPNGGLVSVRDHVIVLGEVLEIIEGVGAQTEAEERFGLLYADRRYRQLGQCITPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8Q8</accession>
    <name>A0ABR3V8Q8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000236">
        <property type="protein sequence ID" value="KAL1838130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="587"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1838130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="700" mass="76080" checksum="88A07CD63ABEC495" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8T5</accession>
    <name>A0ABR3V8T5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-lysine 2,3-aminomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000288">
        <property type="protein sequence ID" value="KAL1837498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538:SF0">
        <property type="entry name" value="L-LYSINE 2,3-AMINOMUTASE AQ_1632-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="LYSINE 2,3-AMINOMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58273" checksum="C90531A2478FCC21" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9I1</accession>
    <name>A0ABR3V9I1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000210">
        <property type="protein sequence ID" value="KAL1838499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045013313" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="576" mass="62481" checksum="9128162FADE9D347" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9I3</accession>
    <name>A0ABR3V9I3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="6" type="ORF">VTJ49DRAFT_3083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="JAZGSY010000239">
        <property type="protein sequence ID" value="KAL1838091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="165"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="478" mass="51722" checksum="476874A42285B6C0" modified="2025-10-08" version="1">MTESSATNSVLLDAKTRAEALDRDDPLAFTQNEFNIPSKAQIASTRLPGPAPTEPGREDDKCVYLCGNSLGLQPKRTQTRLSQYLSTWATQGVQGHFKPLDDSPLPTWLDADERASQLIAPIVGALPAEVAVMQTLTANLHLLMSAFYRPDINGKHKIILERKAFPSDHFAVETQIRHHGLDPSTSMITLSSPSSPEDNVLTTSEILAAIDAHAADTALLLLPGIQYYTGQLLDIPTITAHAHSHGIFVIWDLAHAVGNVPLSLHDWDVDAAAWCSYKYLNSGPGCIGGLFVHERNAPGAPQAGNRLAGWWGNDKATRFAMDTEAGFHAVGGAAGFQLSNPSILDITSLSASLEIFHEAGGMAPLREKSLRLTGLLEELLQSLITEPERALFRIITPRDPSQRGAQLSLMLAPGLLLAVMRELERKGVIVDERKPDVIRVAPAPLYNTFADCVAFVEAFGEALAVAKRERDGEGKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9M6</accession>
    <name>A0ABR3V9M6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000216">
        <property type="protein sequence ID" value="KAL1838402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55258" checksum="4194609EADCFB17D" modified="2025-10-08" version="1">MIHWAVLNGESVGGCSSSLRQDMWSSAGPKFRQEDKVTPSPAPPLGNLLNTLRVDDLEPSAKGYLASSRIENARTVTSYSWVDNANSGPTILIPGKPPLWTPQKHPAPLKEDRGTYYRDKNAARYPKHPIEPAAVALLRADPSVPTDVDVFACGSTLGNLLRFVRGQDKSFRMLAYLVKDTVFLVRRENSPTELIPDVRGFGHSFPEANTTWERDVRGSVSNQRLIRYTFGGLDMVVRFEADGYIQSPAAPASKPSPVTPKADTTDSDLITSLATTSISTPAPTTESASSEPHRLTIKPAGSRVPQSAIFDLKTRSIYTRLKRDHLAEELPRLWVSQIPTFILAFHTRGLFKKEDTEIKDVRQDVQNWEAEHKNELASLVALLHRIRDILKGQPGQKVELVHSGDGTLEVREQLEDAGEVMSDAVRGQWEASGEERKEAGDKDRDQDSRSTHDQEDNDHEDDEEDAEGGIKLTWDDGEEEDYTACTADSCGYCGRCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9U9</accession>
    <name>A0ABR3V9U9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000204">
        <property type="protein sequence ID" value="KAL1838614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="572" mass="62856" checksum="7AD2D965C81DD0E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9Y6</accession>
    <name>A0ABR3V9Y6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_2507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000206">
        <property type="protein sequence ID" value="KAL1838580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="38"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1838580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="482" mass="51114" checksum="92F6C240B24FB34E" modified="2025-10-08" version="1">MSAGPLETWEGPEEAVADPGGNPMIEDLNVYYSTGDFAWILMCSALVLLMVPGIGFFYSGLARRKSALALIWLAFISTAVVGFQWFFWGYSLTFSHTGSAFIGDLSNFGLMKVLAQPSVGSSKLPDLLFCLYQGMFAALTPALAIGAAADRGRMLPCIVFMFVWATIVYDPIAYWTWNGNGWSFKMGGLDFAGGTPVHIASGAAALAYSLMLGKRTGYNKVNGLPYRPHNVTHVVLGTVFLWVGWFGFNGGSALAANLRAVMACLVTHIAAGVGGFTWCLLDYRLDKKWSTVGFCSGAIAGLVAITPAAGFVPPWAAVIFGVAGGILCNFATKIKFLIGIDEPMDIFAEHGVGGIVGNLLTGIFATDYIAALDGSSFGENAIPGGWVNGNWIQFAHQLADSVAGFSYSFVVTCLILFVMNLIPGLSLRVSAEEEEIGLDDAELGEFAYDYVEITRSVDSTATPAVGTSPPTSVKGVSAAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA06</accession>
    <name>A0ABR3VA06_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000230">
        <property type="protein sequence ID" value="KAL1838216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="343" mass="36885" checksum="FA5C3076E83922D8" modified="2025-10-08" version="1">MMFLDPAAPSLHRKRSRDEDEELSPSLPMGFTEHRSKRLQSLPFRTSPTSKRWNEQLNFPLLNPTYPAPVPRVVTPQEPIQDGMWADEPELVTTAPAMSDGDMDMMDTSEPMSQPTGPRSAIPGHLHSAAGVRGRIPTPIQCSFAAQVRGNAWTGRTSMSGDALATTPEEPTASPFGPGGMMGAPTAAAADWNSVAENRRLPSPISECGPEDSQGMALDPSSAPPPPQSYNVSTGDNNLNQITHEHPLIAELPTRTGSALGRREGTPGTDRHGRSGSGSSSNGGMDVEGASPPRRGHTRSKHTLNSWTALQPGMTRTFSIGYRADCEKCRNKQPGHFNHIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAL7</accession>
    <name>A0ABR3VAL7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000194">
        <property type="protein sequence ID" value="KAL1838768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="460" mass="46599" checksum="1EA05CD79A892EED" modified="2025-10-08" version="1">MIEAATQTRVGGSLDMTMFGKSSTPHHRDQHSQFSDHAADNKTDQSGRTGRRRPFSALMKKLANLKAASDSRYSASKRSGTKKHLNNPYPQSGFANVNIQPRHSRSSVSTGPSSSLGRADSTRRYSDEPPPTANGARSVAPTVSTEHDACRSIIATSHGESSLAGTSRTTNGRRGGDSTFSSPAPSVRSLATTLTTIQTVAPNGGGAHHAHHHSHASTSQTIHFHQPFPTGPPASAIPPHLAGSTSPAGPGAAAGSFQLTTYASATANNLLTDNASILTLASSSKRRRRRHSLDTDASVRALAPSSLWGGSRESLPLSVLSATLEGAGTTGGAPPPPTPGGGAGLHRAGGSASVGGGANERASIYSATGILGTAAAATSMSAGERSSFYAGKGPLGSVGGGVGGDAASVRSGLLGHGRQDSANGSIGGTGATATGTSPLATPREVEAEKEKEVGEREKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAL9</accession>
    <name>A0ABR3VAL9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2236</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000194">
        <property type="protein sequence ID" value="KAL1838774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PEP5/VPS11 N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="425"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting protein 11 C-terminal" evidence="11">
        <location>
            <begin position="907"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="623"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="955" mass="106220" checksum="E138DFD1D76F73AA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAR5</accession>
    <name>A0ABR3VAR5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nineteen complex-related protein 2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000185">
        <property type="protein sequence ID" value="KAL1838920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="473"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="63316" checksum="54742712A1A935DD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAW2</accession>
    <name>A0ABR3VAW2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_2174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
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                <person name="Nguyen T.T.M."/>
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        </source>
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        </subcellularLocation>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000159">
        <property type="protein sequence ID" value="KAL1839409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase II subunit RPB9-like zinc ribbon" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="262" mass="27665" checksum="C8854683167DC731" modified="2025-10-08" version="1">MSSPAASASGGDSKNPVDQITFRFCSECSNMLYPKEDEAERKLMFTCRTCNFSEEATSSCIFRNTMSNSAGETAGVTQDVASDPTVGSPCFSFTHVDSDRQVSNSLPSPPPLCVGSPDSVTSSLASTVASASITSSTCTVSSCLSCGRIISCNVCHRLLEAPPSPRPLPYDPDLIADDASVASCEVDPDFDDLGDVDIDLDDAEIFAWTGDSLDELGTILQPEGLFGMEEVVQAEMELKPTLSPVLVPRVLSQQIVSAATHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC54</accession>
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        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_2033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
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                <person name="Conant G."/>
                <person name="Drula E."/>
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                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000183">
        <property type="protein sequence ID" value="KAL1838961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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            <begin position="198"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="530"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1838961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="750" mass="82899" checksum="A54C9AAC203C8B6B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCD6</accession>
    <name>A0ABR3VCD6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Single-strand DNA deaminase toxin A-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000157">
        <property type="protein sequence ID" value="KAL1839442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
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        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24120">
        <property type="entry name" value="SsdA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Single-strand DNA deaminase toxin A-like C-terminal" evidence="5">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
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        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="582"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="640" mass="70476" checksum="AA9C4C5EABD06463" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCT2</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_1273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="187" mass="20483" checksum="CE46072FFEB68B64" modified="2025-10-08" version="1">MTSFKVCSSTMRRPSPVWKAMLFGPWKEAKQSTAAPGWSSSPKTRPRHLQLLPVDITLLTDKYCMEHAVKPWIHEWRKDATLNCNTATKTSTTTSTTATGNTGPSNANIDNTLTDSTLTSDNSSPGNITATANTTVIGSSTVLGTTSPVTIPGAHYGCMREDSVYFLVIMGEDFKLPRERREQWGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDI9</accession>
    <name>A0ABR3VDI9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000134">
        <property type="protein sequence ID" value="KAL1839940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="84"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="808"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="842" mass="92259" checksum="ACDB975EB7EF43C1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE63</accession>
    <name>A0ABR3VE63_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000131">
        <property type="protein sequence ID" value="KAL1840019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="539" mass="60748" checksum="C5965EB0F6276E5F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEE7</accession>
    <name>A0ABR3VEE7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000128">
        <property type="protein sequence ID" value="KAL1840082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="43480" checksum="38E303EBA88D2986" modified="2025-10-08" version="1">MANAPPSAATEAVLVKSVEMPGDAQKVEELDFNKFKGRPITADDLLQGMKHMGFQASAMCEAVRIINEMRAWRDPESGERTTIFLGYTSNLISSGLRGVLRYLVQHRHVSAIVTTAGGVEEDFIKCLGDTYMSSFSANGADLRSKGLNRIGNLVVPNSNYCAFEDWVVPILDQMLEEQEASKGTDNEIHWTPSKVIHRLGKEINDERSVYYWAYKNDIPVFCPALTDGSLGDMLYFHTFRASPRQLRVDIVEDIRRINTIAVRAKRAGMIILGGGVVKHHIANACLMRNGAESAVYINTAQEFDGSDAGARPDEAVSWGKIKIGADAVKVYLEATACFPFIVANTKAAVTITSTSAPAPPAPPADEQPDLPKSEELAGQMSPLSCESVGIEGLEAALWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEG4</accession>
    <name>A0ABR3VEG4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000152">
        <property type="protein sequence ID" value="KAL1839521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="6">
        <location>
            <begin position="135"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="315" mass="34331" checksum="6D08B724ECF0FB3A" modified="2025-10-08" version="1">MTSILLTQSRMFPEEDFAKQPLPAMTTLRAASKVLRSHAVASASASRFLVQDPPRRDPERKTGCGVLVGGNLDSAMAASASRRGNDDNGKASKKDKNNKDSGKSESSGAAADQLDPFDLTDLTTAFDRAEEHFTSELKKLRSAGGGKFTAEAIGAIPVQPDRKNPQTFPLRELATIAPLGGGSGGGAGARRWSILAFDESSIKPILSAVQRAEGFNQQPQRNPDNPLELVMTAEPERVEETAKRAKEACQAWRDRVRGDAHKRTELVKKLKSKGKMLGDDVRRLTEKVQKLQDERMKVIQQREKEVVNAIMARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEG5</accession>
    <name>A0ABR3VEG5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_698</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000122">
        <property type="protein sequence ID" value="KAL1840215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="348"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="446"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="544"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="705" mass="78478" checksum="74801A0DAD213E0E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEY4</accession>
    <name>A0ABR3VEY4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">VTJ49DRAFT_530</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Cytoplasmic vesicle</location>
            <location evidence="1 17">COPII-coated vesicle membrane</location>
            <topology evidence="1 17">Peripheral membrane protein</topology>
            <orientation evidence="1 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Endoplasmic reticulum membrane</location>
            <topology evidence="2 17">Peripheral membrane protein</topology>
            <orientation evidence="2 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Golgi apparatus membrane</location>
            <topology evidence="17">Peripheral membrane protein</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000116">
        <property type="protein sequence ID" value="KAL1840357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 17" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <keyword evidence="9 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="20">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="21">
        <location>
            <begin position="284"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="23">
        <location>
            <begin position="559"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="22">
        <location>
            <begin position="676"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="19">
        <location>
            <begin position="791"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAL1840357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="928" mass="102777" checksum="99A01C4BEF5AB16E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFI2</accession>
    <name>A0ABR3VFI2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000105">
        <property type="protein sequence ID" value="KAL1840615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="713" mass="78085" checksum="81371A7D1D750A40" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFP0</accession>
    <name>A0ABR3VFP0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="440" mass="48354" checksum="AEA351DE7BD53A5C" modified="2025-10-08" version="1">MAPKNRIIIDTDPGVDDVLALLLALSASPEDLELVMISVTYGNVPRQSCLRNVVALFHVLEKEMAWRAATGRPRYGSLSAYKPIVAVGAEHALEDEQLVQDHFHGSDGLHGVHDAYQHPHLSPADTWRTLFEDCPSPTGSSADPPSYSRYFTPSKTPSHKEMLRILREEPADTITIIAIGPLTNVALAASEDPETFLRVKELVVMGGAVGVPGNASPCAEFNCLADAVAAARVFALTSPDPASTMPPAIHGKTILPPYPKGLSRQLRLTLFPLDITTSHEMTRRVFGERVQPLREAGSPLAQWTETFMNGTFDKIDAILGGNENGEGLSLHDPLCVWYMMTRDDPKWRAVAEPEDIRVETTGQWTRGMQVVDRRGRAKPAGKDSMVQTHPDDPMEAVEFDHIPGDTMGWLSHRKGNRINRMVESPGKDTFAQILLDMVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFT6</accession>
    <name>A0ABR3VFT6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_293</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000106">
        <property type="protein sequence ID" value="KAL1840606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="261"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="565"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="666" mass="75871" checksum="0A2A95F0E43FA4E8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFT8</accession>
    <name>A0ABR3VFT8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="13866" checksum="6E75D4BA606E5271" modified="2025-10-08" version="1">MPQAGLKTIIALSFVLAVGFLLVILSCALWHSYYPLLVVATYVLAPVPNWICGHCANPDDFVESAGAAVLDLGRFCTGFLVVMGIALPIVLAHSNLISVPAMIMSVVGGLLIYGTIISFTMFFQEEQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGN5</accession>
    <name>A0ABR3VGN5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_152</name>
        <name evidence="12" type="ORF">VTJ49DRAFT_4445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000346">
        <property type="protein sequence ID" value="KAL1836950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000100">
        <property type="protein sequence ID" value="KAL1840760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1836950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="195" mass="21350" checksum="1211527927AF3CB7" modified="2025-10-08" version="1">MASRFGSSSLHQRDSRSDLFKGYTGGGGVSSRSVSASPSRHFTPPYQQQHQQQPPAGAGYYGYGGYQPGAASGSNHLGVGGAAESRGFRPATPNRKGQYSDAVLNELESQNDQQVEGIMGKVKLLKDMTIAIGDEIRDSSALAEKMNEGFDQTRLRLGRTMNRMLVMAERTGVGWRVWLAFFAAVIFLFVYVWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGQ3</accession>
    <name>A0ABR3VGQ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="208"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="679"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="737" mass="80555" checksum="13454A19A7381531" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGT7</accession>
    <name>A0ABR3VGT7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000090">
        <property type="protein sequence ID" value="KAL1841025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18780" checksum="2CD35A91A15D5B67" modified="2025-10-08" version="1">MLPFLEVEHLPSASTFYSAVVQPLGLRYFSTEDGHFPSVTFGNTSRRIPIFQIRQVVPSRDRPLRISRIILSAPSEAAADDAYEFALRSTNPDPGDYRSPRHPSDSGAASARRIDTSGGGTRVLITDFVGNMLEIVYQPPPDYPAHYSGSTFSIRLPRPHASSPAVRAILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGV0</accession>
    <name>A0ABR3VGV0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000087">
        <property type="protein sequence ID" value="KAL1841080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF126">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="122"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="566" mass="63084" checksum="3CF5EBB46506EDE3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHA4</accession>
    <name>A0ABR3VHA4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="42"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="486" mass="55013" checksum="5535ED84CA01B936" modified="2025-10-08" version="1">MVSTTDPNNLVMLSTVGHLMSVEAMKAIIWTGFALCFVGFCIRSYIRWVCFRRLLPEDWIMLLALLIMGAASIWAQLRLQWVYLLEDVFNRVVPMPKTFLDHDIYMALHGILVQGILGYTGVHAVKLSFLLFFRRLGGGLLEYNIFWWIVAVFTLGSYIVCMATIDYPCMTGSLETLFLHCNNLEKSAMQWRMMIAYCTIDVVSDILILCLPIAILWRVRLTLRKKLLLGAIFSLTLLTVAVTIIRGTIHTGKVSEDGSQTQNIAWTWFWLSIQFITAYIIACLVSFRMLFVHNERNAHAAAYQQQKAALAAAAALQSPSDRPSRSGGSGSGSGQRRTFFDSLLDTFHDWEGTTRDGRDDYRLRGPVPDGHLSVDFSRFQLGDGVQGQVHHQLQQQEEERERRHETGEKKAQYYHQHQYEVFPQYHRGAESDGEWPLRGPVDEESGLRRPESARTLATASSMGVPDHAVGGRAVEQESGVLGSERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHH5</accession>
    <name>A0ABR3VHH5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11802">
        <property type="entry name" value="CENP-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37177" checksum="26903F90897162A9" modified="2025-10-08" version="1">MEDPGSIRVSAPYEAELERTMQALLERKRELEYALHQLRASAAKSGNSECDPLQIMADAYRSVTEAEPVLPPPGPVLPALLAMRRAHQTINETNECIQERSASLEQIQRRIETERARVREQEALQAALKRRIQSLRQGLEDRVEKSEDQRAKERIAELKKQKQHWDVQTSSLMKELDWFIEEHLGPMLAAEELGGPVVGGLMDIDADDLGAGFTAQGKLKTAKAQPDEDKRQRRLDEIWGWQDQQEQTGRRQERNEASAASAEMRDLMEQLMNKLMEAEGDTSAAYVEIPRESAAVRFLVRSKVAEFHPRDARRLRLVDFGRDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHK3</accession>
    <name>A0ABR3VHK3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000107">
        <property type="protein sequence ID" value="KAL1840586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="252" mass="28444" checksum="4090FA861CA74B4F" modified="2025-10-08" version="1">MTTFSDAAQFDRDLRAARTEWKHHKDHAVKWAHGARPIAGVWLDWNGEIGPFCRAPESMLAKARPCRNPRSEYHGIHPQNIVKLPRRGQWYTPLVRQRVASDVLVEMQDATSTFMPRRSGNFNSNTLSSPTRIRSNSMSSSLSALSPTSTSIPDPFIYSFDRTESPNRPLTLEVFVKPSSGNKRHGGRGGGETERLVEREYEVVDENGEALRGRKVRAVLRKEEKGRRERKGENGGGAEEEGWEEDEGFALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHQ1</accession>
    <name>A0ABR3VHQ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000077">
        <property type="protein sequence ID" value="KAL1841388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="32813" checksum="EA99854B0718383D" modified="2025-10-08" version="1">MSSSGCALYAELLVNIRQISIGASLDSPSDASTQISLSADGRTVNLAHRGQTARLILPGKAAVGGTLLPIQERQKGSTSLSWRLPADGASLPPSHRQTGVEDIPWSATDLAPTSGVACRHCGADVVPSGSVKVWKDLPSENWAEMMEFWHCHKPDHHHHHHHGNGDDRDSGTADEQSLASRGYGASSAIQAQESVGFVDLTSLLFAETDCRNLTFSWSSHDQGAPDSQTSASGAVPTGPECLAATLVASAARSGSSKSLVTPMPDAVQGDQSKVAGTDALHIWMLNSGIIFSSSGVPHFFREEPSVRLFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHX8</accession>
    <name>A0ABR3VHX8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_7164</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAZGSY010000079">
        <property type="protein sequence ID" value="KAL1841327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1841327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="611" mass="69320" checksum="62C236EA35F4E2BC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI80</accession>
    <name>A0ABR3VI80_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_7061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000075">
        <property type="protein sequence ID" value="KAL1841446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="329"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="621"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="931" mass="104236" checksum="7FE845CDCD2E7ECC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIB9</accession>
    <name>A0ABR3VIB9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045286996" description="DUF7707 domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="9">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="638" mass="69864" checksum="406D6EF1EBD9AE58" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIF8</accession>
    <name>A0ABR3VIF8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6719</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000067">
        <property type="protein sequence ID" value="KAL1841680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="337" mass="38142" checksum="E0274D487938BA30" modified="2025-10-08" version="1">MASEAFQPQWSWSSAMDGADGHRAAPEAQARHPPEGATSSSSSSTGPAPTPTQQQRQRHYRPRTCRICLDVVYPTTEIDDSLAGRVFSNKARVRYVSDDPELGRLISPCLCKGSQKYVHEGCLQAWRTSAPLSDRNFWRCPTCQFEYRLERLRWGRWLSSKPLRAGLTFFIMAFTVFLLGFVADPILNLWLDPFGSIFGTFIDFDLEDPILMDDEDVGTWSMHFVKGFLSLGLLGFLKTMVAMSPWHWFNVRFGGGRRRRGTGRDRLEQINWALVVIGVLTFLGATWKFVNHIMARTLEKASNRVVDVQEDDPDEDDEDDGPAPQQEATAGESRKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIG3</accession>
    <name>A0ABR3VIG3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="510" mass="59540" checksum="9FE11A32A547E4E4" modified="2025-10-08" version="1">MDSPIVTQLFRQLFRHHPACQSRRNLATLASALRDVRRQHQFLQQQRHHGRRSYASGGRGAGRTSQYDLNWQQRSDIFQQDMSDEFKKYPLVTAMDLRNRTERPRRVKMLMRDFIEDSLYNPNYGYFSKQVVIFTPGEPFDFSSLYDELDFHSLLSRRYVEFEDDLDAVSPSDTRQLWYTPTELFRPYYGEAIARYLVANYKLNTYPYHDLIIYEMGAGRGTLMLNILDYIRDVDPDVYDRTKYKIIEISAQLATLQNSQLVQSTAARGHADKVEIINQSIFDWSSTVPSPCFFLAFEVFDNFAHDVLRYDMETQQPLQGLVLVDEHGDFYEFYTPQLDPVAARYLRVREVATGGRHKVPYPTTRFGRWLAGQKLLAANLSAPEYIPTRLMNFFDVLGRYFPAHRLLTSDFHSLPDAIKGLNAPIVQTRFQRRPVPVTTPLVHQGYFDIMFPTNFQTAEATYQAITGKLTRVLSHEEFMRRWAYLEDTETQSGENPLLTWYKNASVLFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIG4</accession>
    <name>A0ABR3VIG4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000067">
        <property type="protein sequence ID" value="KAL1841673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="319" mass="35326" checksum="5365B489735489A6" modified="2025-10-08" version="1">MTNTNIRCLNGEWKPRSAFSARQLSKYDKEVRTGRATPKNSGIRCTEHSAPQIRNLECQGPCGRIRPETLFSKSTKRNGTYWCVDCVDSNVRAEIDEAFDAPGEELDPGAYQPGMTSYTVQVDDDEDFVVQSGMTSYTVQVDDDEGLVVVANADNATAAANVAEDAHGANGAHGASTANVNLPIQANVGHTEVPFVSVPSLAQAVADAISTPSAAQSSEAVRNEEPLELCTEYFDYLDFLERLNKLFLEVAKTRPPTWIIPDLTDAWQDELAWVQKKQSKRVAKVEKAWPKPESTRKLAPRIPDYQRADIKTFQDDEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIK3</accession>
    <name>A0ABR3VIK3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_7246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000080">
        <property type="protein sequence ID" value="KAL1841301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="984"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="835"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="853"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1133" mass="123555" checksum="A4697012CF3E88CF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJD1</accession>
    <name>A0ABR3VJD1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_6238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1841995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="523" mass="55094" checksum="A3469458FB975301" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJQ9</accession>
    <name>A0ABR3VJQ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000059">
        <property type="protein sequence ID" value="KAL1841933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="273" mass="29402" checksum="9C764D4885CF622B" modified="2025-10-08" version="1">MSKLLKTLCCFSRSSTTATTTTTRSVATAAAAATTSTPKPSVHLDETKPTTSTPSTMGSIPTPSSSAVNPATETFLSLLESRRSIYPLTKALPIPEARVQDIVSRALQAVPSSFNSQSNRAVVLFGAAHDKLWADITTGALRKVVPAEQWEPTGQKMAMFGGAAGTVLFFEDQEPVKKLQEGFPMYADRFPTWAAHSSAMLQLAIWTALESEGLGANLQHYNPLIDAQVAEEWKIPSSWTLTAQLVFGGRVEGQDPGEKTFQPLEEKLKVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJV4</accession>
    <name>A0ABR3VJV4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="170" mass="17913" checksum="1ED1F2BFE89CE535" modified="2025-10-08" version="1">MQKIQLALRATQLLFIIILTGLIGNVIASNINAASSATAAINFTMFVIVVSWLCTLLGLVAALIDRVSLPVLALLGADAFATLFTFIAAVVLSAKLGAVNCGNTKGRSASWIAYGSANDTKRCREVQASAAFMWFLFATFTAAMTLGFLGFRKGGGSLRSSIPTMSQVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKC7</accession>
    <name>A0ABR3VKC7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000063">
        <property type="protein sequence ID" value="KAL1841818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="371" mass="41372" checksum="7284917F059745B6" modified="2025-10-08" version="1">MDRGTQVSLALWGMSGLALILVALRVYIRLRIVRFFVLEDYLYISTFIWLLAFAASIQVAIHYGVGRDVWTLTADEIANTLFWTYVGGSIIVTGNAFAKLSMGFFLLRVVPHQRQKILLWILVFITAATSFILVVMIWNQADPVQASWDVYRTPGVWKLDLIPLCAGLGAWSSACDFFFAVFPWMFVWGLQISRREKILVAGGMSLGVIAGACGIGRTIVLTQSDKEDYTMGFSRYYIWAGAEVAVALVCLAIPTLRPLYQKARTRKTGGSERTEGHELRDAPRRPTDPDDVELALQDTRKSEVLSGPPLQEDVDDRPPGQQQEVEIRPPGSSDSFCPSTSDTQAIEEVPPTGLRPPPRPRNFSRVLTAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKK1</accession>
    <name>A0ABR3VKK1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="311" mass="34862" checksum="E474AD371F747688" modified="2025-10-08" version="1">MSTSSIEDAARSDTDIFLVATGSQHAMIEYEAPQTSCLLPQPFDTSKSGTDDTALRPPEYGANMVPLGILFPGAGPEFASNKTKEEVFQNYQALDVEIPVRTHAGNLSTPPLENESNSTVRPATTSRPLRSSTTSKAEEKAKYRCKFTGCGRGASRQADLERHYATVHFAVFGSDGPDALPTDKKKRKYVCDYKMCARHTEPFLRQDHFRDHLRFFHKEDIPRRGARDEGDEWWETRAPCAVSKGWWRCSKCLRRVTMKKHGFTCPDCGRTCERQRQEYRVKLQEKFPAPAAAYALSLDKNAAARSVAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKK4</accession>
    <name>A0ABR3VKK4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">VTJ49DRAFT_6011</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000053">
        <property type="protein sequence ID" value="KAL1842132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="18">
        <location>
            <begin position="216"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="971"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="85"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="506"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="673"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1288"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1288"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1324"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1335"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL1842132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1467" mass="162383" checksum="68FCAABFFC629D68" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKQ8</accession>
    <name>A0ABR3VKQ8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="85"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="396" mass="44649" checksum="4ED5B8C0E4F5B5CE" modified="2025-10-08" version="1">MGVETVLLEEQPQVWRNLAVKADRAADHFPITHTWPAKLEGPLVWRPDSFVSEDDYTLALTEDEIAEVRAGLKHFKNLDLYGSEVSPETFPLSTLGPKLRGLALEIHRGRGFAVIRGLDPDEFSPEDNVLIFLGVSSYIGELRGRQDEHGSMLMHIRNASHSQTPQQDRPTRYSSRPSTFHTDTFADILALHTLRPSLHGGRNLLSSASTIYNTLSLQPHHRRLIELLAQPCWSFDSRGSFLPSSTRPLLHYHQGRVMLNFAREPILGLPGVKRAEGLAEATASQRRALDVVEETAKQNQVVLEARKGDMLFVNNHAVLHSREGFEDHGGDGRYLVRMWLRNGELKWDLPEGALKEGNERIYGRDGGRDHEDELGEVWNVVDVPRVAFELSERLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKU5</accession>
    <name>A0ABR3VKU5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Karyogamy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000045">
        <property type="protein sequence ID" value="KAL1842362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="829"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="898"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="963"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1159" mass="124645" checksum="5FC9E0C52CEA2E2D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKW5</accession>
    <name>A0ABR3VKW5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000040">
        <property type="protein sequence ID" value="KAL1842529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="169" mass="18788" checksum="99599264A0A9435D" modified="2025-10-08" version="1">MGQTYLTLEAAEGPERGPFLCTDRDHVDGSIPSHSRARGPVDVVAALSEDPVSGRGGKLGRDFSRRLEIVLSPAGSNGRNVGVAVVVCSERREQPGENAGKPRRRTEECLGRERKGWKSQTRTQGSRLESVGKRSRIEMKPNSKLRRRLFGSRARKVRVVRILIKMGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL20</accession>
    <name>A0ABR3VL20_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1842080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="294" mass="31791" checksum="0516046794A5CD49" modified="2025-10-08" version="1">MTSIGTGYDLANSIFSPDGRNFQVEYAVKAVENGGTSIGIRCKEGVVLAVEKIITSKLLKPNANKRIATVDRHLGIVYSGMIPDGRHFVDRARDEARAWRDTFKSPIGTADLASRMGGYMQAYTLYQSVRPFGITAIVGGYDPSVDLPVDGEVGRGPSCGAGGKIPGKNFGGPGLYMIEPSGLYWGYYGAATGKGRQAAKAELEKLDLAGPGGESLTLEQAVKEAARIIYVAHDDNKDKDFELEMTWISGPEGPTKGLHQEVPRALREEAERLAKKALESDDEEEEGKDDKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL96</accession>
    <name>A0ABR3VL96_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_5204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000042">
        <property type="protein sequence ID" value="KAL1842467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="171"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="573" mass="61790" checksum="4C64FD1384296F7F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLV2</accession>
    <name>A0ABR3VLV2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chalcone/stilbene synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000061">
        <property type="protein sequence ID" value="KAL1841876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF46">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="429" mass="46072" checksum="1626F026A1F0B866" modified="2025-10-08" version="1">MASQPEFKNLGLSILGIGSQYPPHSLKPESVDVLSKRFYPESPAMTKVLAINRYTGIDQRSSIGTPDHPLVNQPNPPTIKQLHDIFMSEGVPLAVSAARKALAEARLAPGDVTHMVSTTCTDSANPGYDHFVARELGLGLGVEKVLLHGVGCSGGLAALRTAAGLALGHSRLGRPARVLVVALEVSTTFVRSELDSVNENQETRIGVALFSDCAGALVLGNDIPLRKSEVVEAPPIYTLLGWHHNIIPDTDSDLGFDVDPMGWKVVLSPRVPGLAKTALRPAFDALLASVPPLRKTRDGKRQDEPTEGLQQLSKADSQKATNHPDEEDHNQSSYSKPSDFDWALHPGGAAILTGAESALGITPHHLRASYDTLRRGRGVGEEEDHDDEGDNRDVDARVDGAPNGVEVNGSEEGKEEQPREYVVAYVSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VM70</accession>
    <name>A0ABR3VM70_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF3955 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="6">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="606" mass="66959" checksum="3B2EBCE9F7AD2B85" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMK6</accession>
    <name>A0ABR3VMK6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="2">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_3588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000028">
        <property type="protein sequence ID" value="KAL1842947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0216">Detoxification</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="10">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="154"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="424" mass="46429" checksum="239C47C4F0605D19" modified="2025-10-08" version="1">MAALTEQQIAIVKATAPVLKEHGVTITTVFYENMLRDNPSLKNIFSMTSQANGRQPRALAGAVLAYATYIDDLPKLAHAVERIAHKHASLFVTADQYDIVGKYLIQAIGQVLGDAATPEIVDAWIAAYGVLAKVFIQREGDLYKANAANGWTTQSWRKFRIVKKVPESSVITSFYLAPVDGVVPLPRYLPGQYVSLQIHVPQLGHLQSRQYSLSAAPQPNGEYYRISVKREDADTAAGVAVPGLISNLLHSKYNVGDEVELSHPQGEFFIDPSDSSKAGVPAVLISGGVGATPLMAMLESLTSDSAAKRPVSWVHASRSRAVQPFAEQVKQICRDNQNVTANVFLRNAGPDDRQGEHYNFADTRLDLDKLDQDKNLFLNDARAEYFICGPEQFMVDVRAALVARGVDKSRVFLELFATGDVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMP3</accession>
    <name>A0ABR3VMP3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000030">
        <property type="protein sequence ID" value="KAL1842882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="238" mass="25579" checksum="70C5E931F9DC81A0" modified="2025-10-08" version="1">MAETTDSVPLNFGSLFLILVVSGVVIRYLFFSPSSSSSSSTSGSARSAARAAEQLRAREAAAERITQMFPQIDRRTALWDLQRTGGNVALTTERILAGRIETVRLLLSSVHSAHFGLPMRPPITFQPPPPPGSNNANANPITTPQSKPAAPTPAYPDLITRYNLHDKLKAQTEGDDAAASSTGSDANGSSKAKGWSQNRDERQSLLQRRRDQMILEARRKMEAKIAAEKAAAGKAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN12</accession>
    <name>A0ABR3VN12_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000032">
        <property type="protein sequence ID" value="KAL1842800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="144"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="144"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="714" mass="76751" checksum="F5784FB6FA8DA1FC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN94</accession>
    <name>A0ABR3VN94_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF101">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="445"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="617" mass="67837" checksum="060F5126D7844788" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNT9</accession>
    <name>A0ABR3VNT9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
            <shortName evidence="2">6PGL</shortName>
            <ecNumber evidence="2">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_1777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="262" mass="28666" checksum="60600964F2C98344" modified="2025-10-08" version="1">MTKQPSLYAFPTVDALASALRAYVIHCQEAGLARHDVFKVAVSGGSLPKTLAQALLAPPTSEADTVKWDRWEIFFADERAVPLDHPDSNYGLLKAELLDKLPAEAGQPTVHPIDVEALDDAQELADRYEQLLVKSFAGRDSVRLPIFDLLLLGCGPDGHTCSLFPGHELLREETAWVAPIEDSPKPPPRRVTLTLPVVTHAVRVAFVATGAGKREVMKQIFDNEGYGLPCAIVNEGTGERCSWFVDNDAVEGVGYPRRPFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP10</accession>
    <name>A0ABR3VP10_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000015">
        <property type="protein sequence ID" value="KAL1843502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="676" mass="73729" checksum="6177EB3A83A1907A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPB7</accession>
    <name>A0ABR3VPB7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="192"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="408" mass="45149" checksum="75894D6F171AA267" modified="2025-10-08" version="1">MNVANIPATVRISGPPNSSFLVGYPGISATLSTPRIVGKVEIRPGAGISAPVMISMVRICLQRRETIHPAAENVAKRHLGTPRRETVDLVGKEVLLFRCVSGKDAESVIAMDLPFQIFIPFGRGGEEVNRRIPPASLQLPSRIAETYYELVVTVQQGPSTQNRYTFPIPLQRYDTLSTFGMYNRPENRAATADHIVNLGISLPKWSYGPLDPISVYVKISPNPDCLNKARRVTIQKITLTIEEEITFNPEGDEPTKKVNKIAKHTQPVGTKLPDTGYVTSLGLVLPARDLRDPDGIIKRGKPAFPMYEVTSFTTTSTLYKIEFYLSIKAHMTSARDITLRLPIVVCPMDQQACKEEMEAIEQAAKDASHVDPNNPVLPDRVIVLAHEREAIRYLGLCEVGGVKKMLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPE6</accession>
    <name>A0ABR3VPE6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">VTJ49DRAFT_380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000011">
        <property type="protein sequence ID" value="KAL1843680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046224394" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="27"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="199"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL1843680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="343" mass="35611" checksum="215F9768AA6A1ED7" modified="2025-10-08" version="1">MRFDTSPAPTLLSLLALAALPPGTVARRPKDAILLSEVQSLTFTHPHQTTSRRVPSIPQLRCTSHPRLCALAGPLRTMRCTNQGASYTSQDIQWACTASLPASFQLDRTDVICEGYDSPDDAYVLKGSCGVEYTVRLTELGREKYPELARLEDGGGGGFGWGRREEGGGGDWAGYVFWVLFVGVVAWMVYGACVNGGGRGGQGGNNNNRRRGGTGGGGGGGGGGWGPGWGPGGGGDDNDPPPPYPGTGPGSGPKWSSSTGAQGQEGWRPGFWSGLASGAAAGYMAGSRGQRNNDTNYHRRGGSGLWGDNAGSSGWASGRPSRSDNADPGPRQGSTGYGSTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPG9</accession>
    <name>A0ABR3VPG9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="308"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="482" mass="51943" checksum="F0327E7BF9DAA349" modified="2025-10-08" version="1">MARGAEERPQAAASSSKEKLPTLEEGTTSKKGRGLLPVPSRSSSQRQASPTVSGLSGVTSGNPRDSVDGRSKESRARPTATPGNSEPNTPVVPPPRKKKGGLFALFGCCGVPDNANGLDAEPPVPNHKLEKIPERPATASRPTPTPSVHASGSKTQLSEKDSSQQTSLLQGPPKNGKRVSATSTQDQSTVGGERDNDSKQTTLVGSSNPVISVDPPKLTKTTAEEDEAVSEKDAEGDTPMPDIDTRQTENTGTINAPNQTLPHVPPPPPVPVPATQNGQNNALVESGSSAFPPDQPQQRFLLPPQAPEHKGRKCLVLDLDETLVHSSFKILHQADFTIPVEIEGNYHNVYVIKRPGVDQFMKRVGELYEVVVFTASVSKYGDPLLDQLDIHKVVHHRLFRESCYNHQGNYVKDLSQVGRDLKDTIIIDNSPTSYIFHPQHAVPISSWFSDAHDNELLDLIPVLEDLAGPNVRDVSLVLDVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPJ5</accession>
    <name>A0ABR3VPJ5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VTJ49DRAFT_7184</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="630"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL1843833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1174" mass="130642" checksum="08D2B77AA9A42FF2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ96</accession>
    <name>A0ABR3VQ96_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="836" mass="89865" checksum="30A4BE0678A0C06E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQB5</accession>
    <name>A0ABR3VQB5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045988355" evidence="1">
        <location>
            <begin position="20"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="469" mass="50409" checksum="C44D5319DD3C7C63" modified="2025-10-08" version="1">MRSPAVLSLLGCLASTAVATCEHECASAYTIPTCQTDSSSTCLTPAARLRARSWPSLTSRTCDCHPVDCPVESKKCTPGPSLPPQLTPQTIPLVCGKKATSNTVTVTYGACPSDNKKQCLLFQLAGNGLEQPKLQIQTSPLTDHAPGQFKYNKYCSGNSCAVPIETVLANENIPSVETLCSSDTKLYIAVHSGVKGDTCWADGEPIYGGNNDKGKSHQKRTSGLVNFLTNVVGKIVDAVQDIKDKVKNNGKDKANNWATQFSISFDCPTGPETCCCCPSSPPPPPPPPKTCSVEAYGWTDGSTVVTESLTDLGCTSNWGWYQKIPADVVAAVEPRGGLVYTGQFKAGLSGLEVGELRVLKAGSNFFVQMIPENGEYIGRVWVQVSCTDPKEKLGDDCRTPSAYSFDSGCVTREYGVEGWTAFDNYGLLNPGECTDYFYFMVYVTAETVVESTETEFYETCAPYPVCDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQR2</accession>
    <name>A0ABR3VQR2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1844003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045090954" description="alpha-galactosidase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="5">
        <location>
            <begin position="33"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1844003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="352" mass="38519" checksum="6A8C10F9F2FDFFA2" modified="2025-10-08" version="1">MRLLSWLLASGLLSATGTLAQVTVPSSFTVGAKFQIVIHNTIDPDSPLEPADALVWDIDLFHLARTPEVANHIRSTNPSATILCYFNAGLAQTSDCDYPRWDSSGLLGNPYDITDPDLFPDERWINIKNATAREWIKWRISLARDLGCDGVDPDNIDGFLNDYDGDNGTGWSLSEDDYVAFVTELAEHAHGLTTLQGNTMLIGQKNAPELIGRVKDVLDFAVLEDCRTINDEEDYEFCTDFKEAYIDEGKPVFSIEYPSTIGENGECWATGASEDEYNVACEEGAAGFSTVLKIQGEGELNGCTQYCDGGEPGTGVVVTPTDPERDGDPCPNDAIRGESLGGQGTGRWRWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRA2</accession>
    <name>A0ABR3VRA2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="635" mass="70555" checksum="15E0F00CC54E7140" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRE3</accession>
    <name>A0ABR3VRE3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047522767" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19976" checksum="753A9B427FFB45A9" modified="2025-10-08" version="1">MRTILTLLWAFAALATATITYQVQRVHNPTSDQNDAYWRIDDAMRKAVARYNRLTPRANKHITVQYVPSVPTADGNINGNIRFGSNRSYMTERTALHEISHTLGVGTTNQFNTRCANNNWPTATALLRSWDGPNAKINCGGGHFWPYGLNYENEWSETNADRHCLMVNAMLADGMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRI7</accession>
    <name>A0ABR3VRI7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_7506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="36948" checksum="220FEE8E43F1167A" modified="2025-10-08" version="1">MAGLIFLIVTSVVMAVASFLAGALPLSFTLSPSQLRLITSLGAGLLVGSCLIVILPEGIEALAASTQHTHDPPSHAKDSRGAVRRADDHHTSTSTPELPAFNIGFALVIGFALMFLIDRLPRHAAENFQAPPASRHVSLDNLAGPGALGEEEEGESDGFLGSLTPSPKQTRSLATTTGLVIHAAADGIAMGASATGASLNVGLIIFFAILVHKAPAAFGLTSILLKQGLSRRAIRVHLMVFSLAAPAGALATYFLVSMIGGERMEGESAQWWTGMLLLFSAGTFLYVAMHAMQDENHSADHSSHHLGSNGYSEAGSSSRRHGKLQMRDTITTVVGFFLPLLTRFGHHHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRI9</accession>
    <name>A0ABR3VRI9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000009">
        <property type="protein sequence ID" value="KAL1843811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="95824" checksum="A21AE74C78D580D3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRQ6</accession>
    <name>A0ABR3VRQ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_22</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1844343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="519" mass="58406" checksum="5F397EBA189B4503" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V0M3</accession>
    <name>A0ABR3V0M3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetylserotonin methytransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000713">
        <property type="protein sequence ID" value="KAL1835355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="82108" checksum="64B321C864498329" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V103</accession>
    <name>A0ABR3V103_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000658">
        <property type="protein sequence ID" value="KAL1835452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="57" mass="6195" checksum="4C88096FE677980D" modified="2025-10-08" version="1">MDAAPSGHHSMLTLLLACLRSPPRPDAGRAASRERCSGGKSHNNSTSCYYDWDCFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1V6</accession>
    <name>A0ABR3V1V6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000543">
        <property type="protein sequence ID" value="KAL1835759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="94"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="603"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="1078"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1300"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1318"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1835759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1330" mass="143990" checksum="2503B42920F40055" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2J3</accession>
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        </submittedName>
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            <taxon>Mycothermus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000484">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="93"/>
            <end position="127"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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            <dbReference type="EMBL" id="KAL1836003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="201" mass="21726" checksum="73DECF55E366366A" modified="2025-10-08" version="1">MLDSVVSGLWALIGEPGGKYARLVGGFEQWVGKVEGMVVMRKRNAAAAHGKGEDGGGELFIPQLSQAWRDEAAAMVRRLDDWRRKLRVLGDVPELPASSSSSTPSTTTTTTTTAAAAETETPTPPPLARVLDACRTLVHGMLAELDEMERVERAAAADEMRWVREMNRRMAAESVSLTDSLSGSRRAGTGERKAGAIWRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2K8</accession>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">VTJ49DRAFT_5691</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000483">
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    </dbReference>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="433"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="492" mass="57404" checksum="4FDA8EA16000ABF2" modified="2025-10-08" version="1">MEASKVLAVEVTDFTDEDLDEYFTKHGRLINVRDPENLPPSFIERLRGRARNQSPTLLSRPVDLDKVSAQLEKVATDRRKPDWEVYSIGGQTYRYCGRMYGGTDIVLSGSTFSTPSSLGCRSPEDPYLTNLRLEREAHDKLVNEGGRPWYPIHRLEKIAEHPERHRHLLRYFQEGDHQNCEALTVFGTQLLRWRGFRVWQMKRRNEFQGRIDEYTAWAKRFLKKRCSYPVPVDFDFDEDLERQHPLTQWIEYLTYEYNFLHTRYSWHLRRTRWYRAQWKALVDSGVLKPHETEDFLLQWEPCLERCAEKERAERAVELALQAVEQGARGDPSAAQARLHEAQERLAAVKRRTGLIFNYIQKTFAYREARRFSQRHEILLQWVKGQLDMILREELEKKAEDNPPCSILEEHKVVPSITVARNDDDETEEKGAGQPEPSSSPDQQQDTVSTTQQAPPTAACRLEDSGSLKRTRDDDADALADRTTPLKRLKCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2L2</accession>
    <name>A0ABR3V2L2_HUMIN</name>
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        <submittedName>
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        </submittedName>
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            <taxon>Mycothermus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000554">
        <property type="protein sequence ID" value="KAL1835721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="185" mass="19847" checksum="251407C0A7928C54" modified="2025-10-08" version="1">MFEPDLPPCTRPIDMVVNYIYCQFATKDPNTGAVIPCGSTYFGDDVALLNQIDYNDPCATGGCLISPDCHSGVCRLARLGGRWICCQCGGRGNEYRQCMHRMRSSPDTFCYHEICESCWADPGGAASSASPSSTSPSSSATAGSASTPGLGSGSNSNNNNNNNNNNNNNNNNNNNNNNNNNKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2M4</accession>
    <name>A0ABR3V2M4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000491">
        <property type="protein sequence ID" value="KAL1835971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="828"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118245" checksum="197DA30469BE933D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2V9</accession>
    <name>A0ABR3V2V9_HUMIN</name>
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            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
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        <name type="scientific">Humicola insolens</name>
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        <dbReference type="NCBI Taxonomy" id="85995"/>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
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                <person name="Reid I.D."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Drula E."/>
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                <person name="Hansel C."/>
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                <person name="Natvig D.O."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000586">
        <property type="protein sequence ID" value="KAL1835623.1"/>
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    </dbReference>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="65373" checksum="AC183D9BB68EC280" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V332</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Mycothermus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
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                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000450">
        <property type="protein sequence ID" value="KAL1836183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="1"/>
            <end position="19"/>
        </location>
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        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1836183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="150" mass="16310" checksum="D0F16F9E1EE6F429" modified="2025-10-08" version="1">MQLSVVTAGLFAVINSVCAAPTLNTGKDEVSAMADVPPWTVQDFQRTCNKKDTSCTITFHIDTKLEPRTPCMYSITGAPASRAPANSITCGPYTISSGWSGQFGEESGFTTWSIVDWNKRLIIWPAYADRELVNGQTVTPDKSYAPQTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Otillar R."/>
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                <person name="Nguyen T.T.M."/>
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                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
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                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000474">
        <property type="protein sequence ID" value="KAL1836050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
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        <property type="entry name" value="Fhl1/FHA1"/>
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    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
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    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="722"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="722"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="801"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1199"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="680"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1199"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1216"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1836050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1234" mass="130628" checksum="088F23EFD80A0C06" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V398</accession>
    <name>A0ABR3V398_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000444">
        <property type="protein sequence ID" value="KAL1836227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="33"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="361" mass="40417" checksum="EEAD7D1EE2883EA6" modified="2025-10-08" version="1">MAPSAIDEVPIVTKNQYPEPLKLSGVLDQFESFDVTPVIGREYKNVNLVDWLNAPNSDELLRDLAITISQRGVVFFRAQNDLTNDLQKKLILRLGELAGRPATSGLHIHPILNSERELGGDDPEISTISSIQNKKFYANRQAAESLSPKKQNSGQWHSDIAFEPVPADYTSLRLVQLPTTGGDTLWASGYEIYDRISEPYQKFLETLTATFEQPGFQRVAETAGFKLYDKPRGAAENVGSELKAVHPVVRTNPVTGWKSIFPVGGHVKHINGLTEEESTKLLTWFLDLVYKNHDLQVRFKWQSPNDIAIWDNRSVFHTATFDYLDGSYGERFGNRAVGLGEKPYLDPNSTSRRAALAKTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3V3</accession>
    <name>A0ABR3V3V3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_5630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000473">
        <property type="protein sequence ID" value="KAL1836056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045557466" description="FAD dependent oxidoreductase domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="174"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="441" mass="48461" checksum="AAFCCE562B75D590" modified="2025-10-08" version="1">MSKQHVVVVGAGVIGLSCALELQKAGYHVTIVARDFPGPFETMDPLEKINYTSPWGGAHNRWVPFHPSLPAHLCRDHYLSVRTWERMASLYSAHPHTAGITFLMGIEYFEDPGPEYLAIKAGLDAMARRPYPSYGDEEEQQASDFLASLPSAALTRDGRYLTRDGSYPTILNVLHPGNPPLDDRIRFGFEYQTWCVNPMVYLCFLLRRFTLAGGKLVHRTLASLEEVFSLFPSAQPDGSSDTAGPVVAVVNASGTGIVPDPSMTISRGQTVLVAEDIVHLKPGNPTGSGTAPNVREDVTVTRQNADGTWSFVIPRGFDGGTIVGGTKEVGNWDPAPSRETRERLLRDVEKTHLTVRRPEEQEGFTVLRDIVGRRPLRLDGPRIEGENIAGKGFVMHAYGMGGRGYELSWGVAEKVVEKVKCHVRNMNVRESEGVADEPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V407</accession>
    <name>A0ABR3V407_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000407">
        <property type="protein sequence ID" value="KAL1836469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09998">
        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="264"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1836469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1206" mass="127785" checksum="987C2FDF6550DE03" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4H1</accession>
    <name>A0ABR3V4H1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000389">
        <property type="protein sequence ID" value="KAL1836616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="352"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50501" checksum="A62754B79D5A865C" modified="2025-10-08" version="1">MDKILISPDGDITVTNDGATILQQMEISNHVAKLLVELSKSQDDEIGDGTTGVVVLAGALLEQAAELIDKGIHPIRIADGYDQACDIAVAELDKISDVIEFSREDTENLMKVARTSLGSKIVSKAHDQFAKIAVDAVLSVADLERKDVDFELIKVDGKVGGSLEDTILVKGVIVDKDFSHPQMPSEVRDAKIAILTCAFEPPKPKTKHKLEISTVDEFKKLQNYEREKFVEMIQQIKDAGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATNGRIVPRFEDLKPEKLGTAGLVREMTFGTTREKMLVIEECANTRAVTVFVRGSNKMVSQTPTSVTTLSNQPATPRSSTKPSAPSTTLSASSATSCATTASSTAAARPRSPAAWRSRTRPSRRPASSSTRCAPSPRPSTPSPWPWPRTAASTPLLHSPRSRASRSRPAPPGAVVWVWIAWAAARMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4M1</accession>
    <name>A0ABR3V4M1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="9">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4745</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000376">
        <property type="protein sequence ID" value="KAL1836700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="10">
        <location>
            <begin position="318"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="556" mass="61987" checksum="4172EAC4EBAB805F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4W0</accession>
    <name>A0ABR3V4W0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000364">
        <property type="protein sequence ID" value="KAL1836804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="558" mass="59892" checksum="C9EE3D48A0D71782" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Z7</accession>
    <name>A0ABR3V4Z7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000361">
        <property type="protein sequence ID" value="KAL1836829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="259"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="323"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1836829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="83715" checksum="ED00757A8209D16D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V533</accession>
    <name>A0ABR3V533_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_4539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="JAZGSY010000356">
        <property type="protein sequence ID" value="KAL1836873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1836873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="510" mass="55267" checksum="BE37845069651509" modified="2025-10-08" version="1">MADTAAATARAAATYKQLKEDFVSNLSGGSVIEIAQVCAVAPIATFLWSALQTRQSLFKPYTPIAFIVDFLLNVGALLLSVTLYSRYPLLLNLLLLGAAVAVYAAPPDVSAAARKKKPQRPPNAPSKTQPAPLGLLSTKPFLTTYRGNMMVVTCICILAVDFRLFPRRFAKVETWGTSLMDMGVGSFVFSAGIVASRAVLRGQAEGRVTPLWTRLARSVRHSLPLLALGLVRLFSVKAVDYAEHVTEYGVHWNFFFTLGFLPPLVALCQSGLRLVPSYAGLALLLAVMYQLALEFAGLKSYILAGPRTNLLSMNREGVFSFWGYLAIFLAGQDAGMVVLPRNPGATPGGLLARLSRGSKRAGLLLRLAAWTVGWAVLYLLCTNYTYGFGLTVSRRLANLPYVLWVAAFNSALLLSFAAVDAWLFSGFYRAQDARAEKEAHDLATSRVLRAYNRNGLPVFLLANLLTGLVNLTVPTLDVGRIATMGILGGYMGVLTLVAVALDEYDITIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5M5</accession>
    <name>A0ABR3V5M5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000336">
        <property type="protein sequence ID" value="KAL1837035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65331" checksum="3441C21E5EB61B8F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5T0</accession>
    <name>A0ABR3V5T0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_4236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000327">
        <property type="protein sequence ID" value="KAL1837124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="772"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
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</entry>
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                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
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                <person name="Nguyen T.T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 620.91</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000283">
        <property type="protein sequence ID" value="KAL1837555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="3">
        <location>
            <begin position="594"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="919" mass="102660" checksum="53BA2B6C47986F9C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7C8</accession>
    <name>A0ABR3V7C8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_3516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000272">
        <property type="protein sequence ID" value="KAL1837690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="148" mass="16516" checksum="3907D39767A74CD0" modified="2025-10-08" version="1">MANKSSELSFLCNPRFGYGLVVGVTQASINATLADYLRAGHEQPLVQTCYVLVPKGSGGDTQLEDPLSDLNFQKLCEARFIMGFQARMGLPKNTSDAPEIVIRVWSLSTWVRASQLDERPWTFSTNVDLCLSQLPHTHFDKLPDKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V7Q9</accession>
    <name>A0ABR3V7Q9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000265">
        <property type="protein sequence ID" value="KAL1837757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="423" mass="47125" checksum="3F63558E828E4944" modified="2025-10-08" version="1">MSPTKSPGFLHFYGQLLAESHSRFAIVQEDGEFNEIPLTLLTLYHLGIRDQALVRRTYHALAYTCSLWTLSPAPITNEDLYRGRHSYQRAFVDYFALTFLHNNFSKACIRHLLFGGERPLIYGLFPGRGLSMFGQPLVTLADSLDLFNQGAHHNTPGNNGLFVGSLLMSEALGQAATSWTGDLFELLSCPTTPSGAPAVSTLLSPEEVLDRVAFDGRFSGIMRAGPGFYRVDDVLKNPAVRGAVVGYLRRTELRLDDGSIADMAYLAASLLATTHVPGRVAFDYFLTQLPTYVWSARVLMTRLGPALSAGDRLALLRMLWCVVLLTYVTQLRPRRNADLLLAGDVAEEYRGWEEMFEEVRQQQAMGSGSVVFMRALVSLRRLDRVFRGLHGHLYLKAGWKLVKSWEGWTGLGQAGEVTMNVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V855</accession>
    <name>A0ABR3V855_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000249">
        <property type="protein sequence ID" value="KAL1837957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="594"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1837957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="95656" checksum="364CE1BCB8291430" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V869</accession>
    <name>A0ABR3V869_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000259">
        <property type="protein sequence ID" value="KAL1837835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1837835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="387" mass="44227" checksum="DE81F9C7ADC9B0AE" modified="2025-10-08" version="1">MNPDDVHNPACAPEVAPKRGPGRPPNPVSEPPSSNRRPGRPKKDQNPQAKRGLGGQPPNALDNTPKEDRDDTNEFMALLPTAVISESWSQANEDSLVAAWNQHPSKAAIAKKCKKLKPFGAELKLWRHAFASLRALPIDIIDFRKNMVADCSSSSQFHQRRQVPQLTLDNIELVLWSSEFSFELMKVIDHNAWEGRASLLRFAIQYVVTCATDDRRPWALDAEFCDPFNPFLWRLAKRMRENTTDVPAEDIHAAVWQEVSESLGYFTRPWWSRLFLAIEELTRDERELKRIFRSSLLRSQGPETVWMPYVVRKDDLTCLKTALQKADGGLEVSLPRELVPVFLTVERYEAALNRVWMSWFRLLKQGLLPSHDLSIESGWEEGILLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V874</accession>
    <name>A0ABR3V874_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000244">
        <property type="protein sequence ID" value="KAL1838013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27359" checksum="42FD31F6FEC77B69" modified="2025-10-08" version="1">MGRVIRNQRKGAGSVFTANTRLRKAPAKFRSLDYAERHGYIRGIVKEIIHDPGRGAPLARVVFKSPYRFKQITETFIANEGMYTGQFVYAGKNAALTVGNILPLASVPEGTVVSNVEEKVGDRGALGRTSGNYVTVIGHNPDEGKTRIKLPSGAKKVVPSNARGMIGIVAGGGRTDKPLLKASRAKHKFAVKRNRWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRFAAPGQKAGLIAARRTGLLRGTQKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8K8</accession>
    <name>A0ABR3V8K8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000240">
        <property type="protein sequence ID" value="KAL1838071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045681101" evidence="2">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="423" mass="47796" checksum="A1F96E645658F32F" modified="2025-10-08" version="1">MRATRLLAPLWLLSGSLVSAGYDARGPEVEFFYRAYRMDVDISVAEFLADPKNKDKDPNVEKPWHLARHLSQTLNDDADWPKGGKPDKFYGLNFHAWMAGVSQSGKYGRNAARQRIDDPVNPDFKAAFADTKDADGNYLEPRRNIMRLPPDGGWALDPINPDNSFKNDKSEKKWSWTGFDPNGLLGGLNKSKKGNKLGSYFEFDNILGIIANHCSELYKKNPDVGKPHFEAMAEALKHAQLARKMESSKYQTEAARRVLQQYDSDIKRPGTVSGNKNALKTTGKKIVSSNAWFPGWKYDMLDIEKTRKNWPSNLESHKNAIFTEGKYLHKFSQQWAKGDLSYLNDKGKRVLDPGTGDNHNHLQVTKAERRLEMAIREQIKDPNLTPGAPGCDWFKTREPGDGPGDPLKRRMALDMLRDAMSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9M3</accession>
    <name>A0ABR3V9M3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome component ECM29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_3378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000261">
        <property type="protein sequence ID" value="KAL1837813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="7">
        <location>
            <begin position="1290"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1702"/>
            <end position="1727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1837813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1811" mass="198783" checksum="162389510A7C4B83" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9T1</accession>
    <name>A0ABR3V9T1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2992</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000235">
        <property type="protein sequence ID" value="KAL1838141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="118"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="12">
        <location>
            <begin position="513"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="581" mass="64965" checksum="85DF76A0F78935C6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VA93</accession>
    <name>A0ABR3VA93_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000195">
        <property type="protein sequence ID" value="KAL1838754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24649" checksum="0B119CF449966DC6" modified="2025-10-08" version="1">MTHDHQQPRGQITAANMSSFESVVVIDGKGHLLGRLASIVAKQLLSGQKIVVVRCEALNISGEFFRAKLKYHAYLRKMTRYNPTRGGPFHFRAPSRIFFKAVRGMIPHKTARGAAALERLKVFEGVPPPYDKKKKMVVPQALRVLRLQPGRKYCTVGRLSHEVGWKYQDVVERLEERRKAKGAAYYERKKLAARQLSEAKKNAKVDAKTTEALAAFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAA6</accession>
    <name>A0ABR3VAA6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_2231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000194">
        <property type="protein sequence ID" value="KAL1838769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="647"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1838769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="910" mass="100617" checksum="ECFE9F67EFB76EAD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAE2</accession>
    <name>A0ABR3VAE2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_2250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000195">
        <property type="protein sequence ID" value="KAL1838752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1838752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="124" mass="13795" checksum="2D6A240290B2D59F" modified="2025-10-08" version="1">MSFIFRRLFGTTPTLTMEAAQKKAQQLIDDNAVMVFSKSYCPYCNNTKRILTDLNAKFKAYELNQEPDGDDIQNALHQMTGQRTVPNIFIGRVHIGGNSDLESVVKNGKDGKKIEELLADAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VAQ6</accession>
    <name>A0ABR3VAQ6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000186">
        <property type="protein sequence ID" value="KAL1838913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="458" mass="49704" checksum="3A5E116BE7095BF0" modified="2025-10-08" version="1">MQGKSRRRPNADAAGRAAGASGTSGASDASDVAAAEPDTNASDENMKKLIDEFRSTLEEPVVISIAMDFDLVKDFDQVRQMLSQLAETAPAEAATGFDASGLGSSTEIDGARRDDTGTSPDGLDSWVENENSTTFSEYSDMAENRCLTSLADLTDDQKIQELRVVFQDRWRDTTLQLVLRRCNGSLEDALDELLNRQYLEETGQFQKGVDGFAVEDDEEVGLSRGKSRSIRKTKAPKKKMIPIAYKSVSSSGDDDGELQSAKDFAGATTTTKTSRQARPLPTPGPLLTHPRPITTTSPLLSATTTTPLSPTSPTGSSTTHLLSTAASLRRMGPLGRQAAVVYTERARSERALLAAQASRDAEALVERQSSATHIDLHGVFVMDGVRITRRKLWGWWNGLDGENRKVLARQEGFTVVTGIGRHSEGGVSRMRQAVGAYLRNDGWRFEVLTGRFLVTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB27</accession>
    <name>A0ABR3VB27_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-citrate synthase/succinyl-CoA ligase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000195">
        <property type="protein sequence ID" value="KAL1838757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1838757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="195" mass="20326" checksum="F86542F5576979FF" modified="2025-10-08" version="1">MVRITSMLKSQNKTRLVGPNCPGIIAPGQCKIGIMPGFIHKRGRIGIVSRSGTLTYEAVNQTTHAGLGQSLVVGIGGDPFSGTNFIDCLKVFLEDEETDGIIMIGEIGGSAEEDAAEFLRQNNTKDGGKPVVSFIAGISAPPGRRMGHAGAIVSGGKGGADSKIRALEAAGVIVERSPAGLGKALRDEFVRRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VB83</accession>
    <name>A0ABR3VB83_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000175">
        <property type="protein sequence ID" value="KAL1839093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19178">
        <property type="entry name" value="SET_SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044430">
        <property type="entry name" value="SETD6_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="494" mass="55041" checksum="0B76CEA4FE8F4688" modified="2025-10-08" version="1">MEVDRGFDDHTRDFLNWFLAQPGAVFRSDLMSIEDLRGRNAGRGIIAKTDIAADTVLFTIPRDAIICAGTSVLKDKIPGIFDLDGVAQSDPEDGDDAGSSQDSWTLLILVMLYEHLQGAASRWKPYLDVLPSSFDTPMFWSSAEVSELQASALVAKIGKEEADRMITTKIVPVVRAHEDVFFPAGSQKLDDEQLLGLAHRMGSAIMAYAFDLENEDGNDGEGEDPEDEWVEDKEGRTMLGMVPMADMLNADAEFNAHINHGEEALTATALRDIKAGEEILNYYGPLPNSELLRRYGYVTPKHSRYDVVELPWDLVEVELKERLGAGMTSSDWDKARQRVRSDDEFEESFVLDRSGEDPDPTGQLRGEVIFSGLPDELGAQFKTLIKAAKKAGNSRIAAELLEDKDKRKELYLQAVLAALRARERQYPTSLEEDEQLMTGQLSRAQQMAIVVRMGEKKVLREAQAWVQEQAGVANNSSREPDAQENGRSAKRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VC36</accession>
    <name>A0ABR3VC36_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000166">
        <property type="protein sequence ID" value="KAL1839272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="248" mass="26982" checksum="37C2DE329F6E9CA5" modified="2025-10-08" version="1">MTKLIIPPAPQAPTAPGKRLTARQKARARLADPLLPRKLHREDNVVVDSFINSKRDKRLIKHSAFVSKVTESASQTKSKSGVSKTSGSTKRRRPNKKLVATLESLEDALDDIRAEMAEDEASGKVMDAEQARQGKVRHKSLKTRPGALKRKEKLVKGEMERFRMNLAQLANVSSASSVAAGTGSAKTTAAEGSGVAQQQQGEEMDTTRGKEEQEQTQASATSSRWAALRSFISATMEQNPAFLNGNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCG7</accession>
    <name>A0ABR3VCG7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal targeting signal receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000155">
        <property type="protein sequence ID" value="KAL1839472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="71454" checksum="C788387E829262DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCQ0</accession>
    <name>A0ABR3VCQ0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000152">
        <property type="protein sequence ID" value="KAL1839526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="370" mass="41753" checksum="8D2AD7165F9E93AD" modified="2025-10-08" version="1">MTGLTPCILHRESDDQSGPSGHPITAQGHLPSESAQFKIHFSYSLYPEDSAGEAYYRIKGTDKTFHVQADYVLRPGWWEQRAMIDYSNLETHGVRKGSLIDIGWAEFSNNQPLQWVLTGSEKYGYWSSHNPPVAWMHAILDAMGDRKLKYIACPATQWLDFYGQLVRGSRWFDVRPCLGNGGKHMLGHYSVDRATPAGGNGLSVDEMIEQINRQVASSFMDEYPGELVILDVNNEAGFYTDRAGTPRLTEAQWRPIMNKIQDGIKKPCKGFGERRLDQIPLNEFMGDGKGCVLTVVRSIPGVERDSDKGFYLASQLPQANDYSNTDDYNHMRENQMAKLKLKRRLGPEGDPNTQDEFFVLSWTMTDASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCT1</accession>
    <name>A0ABR3VCT1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">VTJ49DRAFT_1264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="371" mass="41303" checksum="25BC7614C13F25F4" modified="2025-10-08" version="1">MDKDLDARFEKLERALGSMIDSLAKNNPSKTVAEELVAAEAELAEGLKLLERHQNNAVRIQQLRQETSLLDTQIKDIASSLWNMRKELKAVPVTTHPPPNPQYRFTTAELLAYARRISRNTLPLPGVTNGVEIPTPQQQQQQQQQQPSFTQPADADDSFRQTQTPNTSFNLSFAAPTADTSVVFPGSAPTPTTLTQDTTLPPSQQPLQEKLSAAAATAPATKAAAESKLPPNLRPAVNPLRDATFLPWPSEARIRSGALAAVQALVDSGINPKGYDPAEEERRRKLAEEEERERLRREAEEREERERRMREERERMARERERARMQSQQEGGLVPGLERRESLLATGGGGQKPKQFTFLGADDDDDDDDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCU1</accession>
    <name>A0ABR3VCU1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF81">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="584" mass="63069" checksum="CC6B85059C2F35C3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCX6</accession>
    <name>A0ABR3VCX6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_1460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000154">
        <property type="protein sequence ID" value="KAL1839485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048360">
        <property type="entry name" value="Ezh2_CXC_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040968">
        <property type="entry name" value="EZH2_MCSS_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040595">
        <property type="entry name" value="EZH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21509">
        <property type="entry name" value="Ezh2-like__CXC_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18600">
        <property type="entry name" value="Ezh2_MCSS_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18601">
        <property type="entry name" value="EZH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="8">
        <location>
            <begin position="614"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="751"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="888"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113808" checksum="26D30D5691E53BAC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD44</accession>
    <name>A0ABR3VD44_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_1290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047090293" description="Serine peptidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1839629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="62750" checksum="6F93C7586D49FBDE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDA8</accession>
    <name>A0ABR3VDA8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylenetetrahydrofolate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000138">
        <property type="protein sequence ID" value="KAL1839834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="3">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="4">
        <location>
            <begin position="155"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37581" checksum="00752A4EBC365E0F" modified="2025-10-08" version="1">MATQDVPKTCKVILSDTIAKKLLAEARETLATIQGPNASKPTLAAFLANDDPAALQYAEWSKKTCEENGFNFDLRKVDKELLEEAIVAANQDDSVDGILVYYPIWRSNQQQDRYIQETVALHKDVEGLCHTHLFNMYHNIRFLDPPHNTKKSILPCTPLAIVKTLEHLQIYNPILAYGNRLFGKTITVINRSEVNGRPLAALLANDGATVYSVDITGVQLFTRGSGIRAPRHQVHDKEGWQLKDVLPLSDVVISGVPSEEFKVPTELLREGAVCINFSSHRNFDGPAVKEKASIYVPSTGKVTIAVLLRNLVRLIANRPTPEGTSDAAEKTRNEVFQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDD0</accession>
    <name>A0ABR3VDD0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_1235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000144">
        <property type="protein sequence ID" value="KAL1839698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="196"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="723"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1839698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="911" mass="97061" checksum="EEC64500515BB8C0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDR1</accession>
    <name>A0ABR3VDR1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000136">
        <property type="protein sequence ID" value="KAL1839901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="261" mass="29700" checksum="B853CFCEAD27323A" modified="2025-10-08" version="1">MQELEGRIKDGFKKAIDEVVKRLDGLEKEKDKLAKENAKLKAEIGQLTENNNNLTYIVQTWLKGKKHRAASEASDCNYRSIASQAVPPWGPCNKFINFIDLWLLHPDPPKAAQVQNTDSDSDSEFDSDGHSSYSSYDDDDDTDCRIRPSPSFNFNRGYVQLPVEHDVLDFNERMFPGTVMAPSLSHQPPLFLFASLSTANARYLVEHLLTTGTTWCRIWDEALYKWILAEQHSREKSWYWAIMEELMARIRGAALAGLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDS6</accession>
    <name>A0ABR3VDS6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000130">
        <property type="protein sequence ID" value="KAL1840023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="228" mass="24429" checksum="2A115118C31C60A8" modified="2025-10-08" version="1">MSTSYRERRVPNTLPAKFMLWCAGRDPRKVKAIRQYYDEDDTDGQSMSSGESRWSLSNTGNVYLVESTDPYWRQREEAAGRKRRKSSSSKSGRSSRAGGSQPPNGWAKRATAEDDDDDEYSSSEGGDDSYPPPNPGRFPPRPGMAAQNVPPQPPAGGPPPGTFQPVYGPPRPNFAAPPGAVPPGAAPRPAPQGGYPPPPAGGARGPAPPPGGRFVQDRNGVRVFMSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDU8</accession>
    <name>A0ABR3VDU8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_1174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000140">
        <property type="protein sequence ID" value="KAL1839800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="176" mass="18552" checksum="DC508265AFD8A915" modified="2025-10-08" version="1">MSSPSPHPDLPAAVTRVKKIIAMDPDITVCSNNAAFAITLATEMFVQYLTEEAQKMTKLDRKPRRNIQYKDMANAIAHRDNLEFLEDVVPKTAPYKEVKAKAAAARAKVSGEKVAGDAGATAADDRPTDGAPSGKRAKSVVNGFGAATSNGASRAKGHQQSGSVDGQHDGDVDMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VET2</accession>
    <name>A0ABR3VET2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pheromone receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000147">
        <property type="protein sequence ID" value="KAL1839641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14939">
        <property type="entry name" value="7tmD_STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="47754" checksum="A4FD25367C72B675" modified="2025-10-08" version="1">MSSNDTASPGGPPPTGPPPPGFDPLNQTSTLLYSNGVTLVPFNTHFITEQYIEATSLSIEYGSQIGASFIMLCVVLAMTPRTRFRRAATLISIASLTINTIRMVLLSLFFTTTWMNLYILVTYDGSVVPRSAYNLSAAATILSVPVTVLILAALGLQAWSMISLWRARWKVPAVAISALLLLATVAFSMTITILQVRATLYADLSALSSVVAWVRKTYLIFITTSICWFCFLFNIRLVMHMWTSWSILPSLKGLKAMDVLVITNGILMLVPVIFATLEFFDWDHFEPGSLTQTSVVIVLPLGTLVAQRLANPVWFGTGPDPASGASACPHCGRGGTGAATIGGTGTDSHAGTTFGGATIMTTTTSSVASRGTNAKKPLLAGWKRDGGGGGRGNAVETYIGSEKERSGEEGRDEARKGNENDLEQGHGGVRVNYGIARTEERVQTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFF2</accession>
    <name>A0ABR3VFF2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1840537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="400" mass="45612" checksum="C9D1FE8661B68DB1" modified="2025-10-08" version="1">MSDDEADPELLELLRQHLQGKLNLRNDEPETGVLEDARYVYDNAIDVAIQMRACKDAAAVLHAQMRDKGYSTASWGAHELHPDPAAMHGSSGFRRHGHDGGGEDGGEEVDEDDEESGDAAAVAFVFTMDLLNFSFWSAQKEPERRFAVEYRGKRWTGYWSMVAALWRALDEGIPITDTHFWQDEEACTLEVMRHVFRSCTDEEMPLLAERLACLREAGQVLYEKYQCHPLNLVLAANGSAAGLVNLLAEDFSCFRDEHPFEGRRRPVRILKRAQIFVADLWACFRGERYGAFRDIDKITMFADYRVPQILNSMGCLYYSPPLETAIRAGREIPSGSSWEVQLRACSIWCVELILKEIRQTHPDARVNAILLDFFLYDTIKEMEAAGKETVPHHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFF7</accession>
    <name>A0ABR3VFF7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carnitine carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_673</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000121">
        <property type="protein sequence ID" value="KAL1840242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="54"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="153"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="261"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1840242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="36237" checksum="7F2EF64C6F0343EA" modified="2025-10-08" version="1">MSSASSEPRHTAGAAVNETLHAALPASVAGKLPHIPESKDELKADAKAAASTGLAQLRSFVAGGFGGVCSVVVGHPFDLVKVRLQTADKGVYNGAIDVVRKSVAKDGLRRGLYAGVSAPLYGVTPMFAVSFWGYDLGKTIVRSISPVNPDGSLSIAQISAAGFFSAIPMTAITAPFERVKVILQVQGQKKLAPGEKPKYSGAADVVKQLYREGGIRSVFRGSAATLARDGPGSAAYFAAYEYLKRKLTPRDPVTGEASGKLSLTAVTCAGAGAGIAMWIPVFPVDTVKSRLQTAEGNVSIGSVVRGLYAQGGIKAFYPGFGPALARAVPANAATFLGVELAHQAMNKVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFG6</accession>
    <name>A0ABR3VFG6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-xylanase</fullName>
            <ecNumber evidence="11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_438</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045325622" description="Beta-xylanase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="45"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="367" mass="41543" checksum="0A2FC5F0E0D9DB5D" modified="2025-10-08" version="1">MRVASPVAAATSLLLLSAPVTAQLHKLAVQAGLRYFGAATDTPHQRERAPYPESYAQYDAILADNDEFGQTTPTNGQKWLFVEPAPRLFNFTEGDYVADLASSQGKLLRCHALVWHSQLAPWVEETNWTAPALADAIERHIRAVAGYYRGRCHAWDVLNEALDEDGSYRQSIFYRVLGEEYIKLAFRAAAAADPDAKLYYNDYGIERPDSVKTAGALRLVRMLRDEGIRVDGVGMQAHLHADNHPSAEDLIRTSEAYAEVVEEVAFTELDVRIKLPVDEQKLQWQKECYQKVVEACVRVDACVGITLWDFYDPFSWVPHVFPNNGASLLWFEDFSKHPAYDGMVETFKSLIAERESKQQRRSLEWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFL8</accession>
    <name>A0ABR3VFL8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000104">
        <property type="protein sequence ID" value="KAL1840645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="817" mass="88727" checksum="BABE798E68D194C7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFS5</accession>
    <name>A0ABR3VFS5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000103">
        <property type="protein sequence ID" value="KAL1840680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="24"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="677"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="819"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1840680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="957" mass="106400" checksum="E0B560C272517EFA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFV6</accession>
    <name>A0ABR3VFV6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oligosaccharyl transferase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000105">
        <property type="protein sequence ID" value="KAL1840621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045673898" description="Oligosaccharyl transferase subunit" evidence="10">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1840621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38409" checksum="E9FA9262EB9D4E4D" modified="2025-10-08" version="1">MRLLPTLLSLLGCLSTTTLAAGAGASGNSKSSTNLRKLPPTERFNLYHGKATASSSAAPLKLLETDYRALVATPRDYSVAVLLTAMDSRYGCQLCREFQPEWELLARSWTNGDRKGEGRVVFGTLDFNDGRDVFMGFGLQTAPVLFFFPPTIGPHAVVPPEPLRYDFTGGAQAAEVVHHWLARQLPDRPHPPVKRPINWMRWISTFVILSGGATASYVAWPWVLPVVRNRTVWAAVTLIAILLFTSGHMFNRIRQVPYVAGDGRGGISYFAKGFQTQYGLETQIVAAIYGVLTLSGITLAIKVPRIADPKSQTVAFLAWWGILFVVYSLLISIFRTKSPGYGFALPPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VG44</accession>
    <name>A0ABR3VG44_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000099">
        <property type="protein sequence ID" value="KAL1840777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="297" mass="33882" checksum="018016AA4669E7EE" modified="2025-10-08" version="1">MPPSSPSRWPSPHRAAIALTMDNLGEAQDVLHGNWPHPIGTHPSITNQLPRMLDLLSRHKLRATYFAEAWSLGVYPEVVARLLREGHEVAWHGFQHEVWSGLGEDEERGNFETSWRALDVAKSAVADAGKSVTSLAAEEAQGSGEDVSVEYRGFRPPGGRINERTWKLMREYGVEYVSPLGEFGIGKEGVAVLPFEWRAVDAFWYMEKFAGIRKEHGEREEVHSPGEFREWLMKKIDEVVEEGRFVSILFHPFLTTSEEKCAIMEEVVKRLSQDERIWVAPCREIAKWVKEHPEHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGD7</accession>
    <name>A0ABR3VGD7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation diffusion facilitator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000101">
        <property type="protein sequence ID" value="KAL1840733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="203"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="404"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1840733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53168" checksum="DBCB794FD942235A" modified="2025-10-08" version="1">MDQPDLSSSISLHPHPFKTQSDTASRLARSTSPRPSQMSIDEGASTALEAPAAGDDAAPVARHPTTALGSSGANTPAPGDVESQRAGRLPLNSRNDPYGLQQRYKTPAQLAEIKANTSRKRDGPPGSGGRGSSGGGESRTTKLARYLKPFGSKASKARKLQNFYQTQNETIERLLKSVDEHCAEARQEQGDDNLKFKIAVWGSLAANVILTALQLYAAISSGSLSLFTTMADAIFDPLSNVTLILTNRAVRRVDANRFPSGKARLETVGNIVFCFLMTAVSLIIISFAARELAESDGELKPFLLPSIISVCVAFGTKFVLFLYTWSIKDKYSQVGILWQDHRNDLLVNGFGILTAVGGAKLVWWLDPAGAIFLSVIITGLWLRTAFAEFMLLVGVVASVEIQQLITYVCLTHSPAIKQIDTVRAYHSGPRLIAEVDVVMDPDATLQETHDVAEELQIKLERLPDVERAYVHVDYETTHKPEHALKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGE1</accession>
    <name>A0ABR3VGE1_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000096">
        <property type="protein sequence ID" value="KAL1840859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="236" mass="27350" checksum="0D7A3AFDCF88D2D7" modified="2025-10-08" version="1">MGYYDRNGRSRSRRPDAFFDSFFDDPFWTDPFSPRSRRRDLDAEAARIEAEMERLMREMHLRREPSSPPRPSRRSRSSHRHAAPPPPPPPPRSPSPPPAPRPSRRSRSSTRHANPRPSRPPSPPRAAPPPRPSRTSTRYQPQPGEFVYHYVRPSHESRSRNHHESRTRERDYCPPRTGGANSHRHGTSGRSRSTGPSPMPRHRYVQYEIEELPDDYRTGWIKDPPIFVYAGTEAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGM2</accession>
    <name>A0ABR3VGM2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000090">
        <property type="protein sequence ID" value="KAL1841013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="283" mass="30871" checksum="E0D21101EAD1BEF6" modified="2025-10-08" version="1">MFGNIPSAIQPPALPEDASTLSWDEKVTPLLLIHDGGGTTFSYYCLGNIGRLVYGIANPRYHSGAAWEGGIPEMARHYIGMLKLGLPRSDGTKRVILGGWSLGGMIALEMARQLAANKDASLSVVGVVMIDTPCPFAPLPIPAPRVVQHVVEWGPLTREDTKRKVQRCFADALRVLGQWTLPEWADAAQQDGRCEKEVPHPPPPVVLIRATGMVPVVEPGVARVDIHRSDPQLGWGRYRKHLVRRAIDVPGNHYNLFQTEETLETVTKAIQQACAGLEDIGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGS6</accession>
    <name>A0ABR3VGS6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000110">
        <property type="protein sequence ID" value="KAL1840498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="70574" checksum="EEC05943BD935402" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGY7</accession>
    <name>A0ABR3VGY7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000085">
        <property type="protein sequence ID" value="KAL1841133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF168">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="74"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="581" mass="62466" checksum="3618825909305C53" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHB4</accession>
    <name>A0ABR3VHB4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="72766" checksum="4B1E6746A17A9958" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHC5</accession>
    <name>A0ABR3VHC5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF3">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047406009" description="Regulatory P domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52638" checksum="F11606FB7F1BE45B" modified="2025-10-08" version="1">MKTTALLALAAAVAPSAASISVPEEAPVYASNAERMDRLTELKNQDWAAAAAQGIGLFNGATRFRKVTAKKKCSANGLADDTYKCRNVDLHGFISHADMGSEVKLGNDVWGWTSPGGREFGIVGQRDGVAFVEITHNGNLEYLGRLDTHTEAVSWRDIKVIGNHAYIGSEAVDHGMQIFDLTKLLDVKPWWNPFFWKPKVFDKEKDLTAHYTGFGASHNIVAHEEARMIYAVGGRSGANARNTTCAGGLFMVDVSDPANPKSPGCVGSGGYVHDAQCVVYQGPQDKYRGKEICFGFNEDALTIYDLTDKANPAVVSRTPYVGNAYSHQGWLVDDSMTFLLLDDELDERDGTAPGRDGRTTTYIFNVTNLEAPLNTGYYKSPARSIDHNQYVVKGLTYQANYASGLRIIDVSGVERDPTGGNFEEVGYFDCHPDDDETGGNIAFIGTWSVYPYFKSGYILLNSIERGIFSLKYTGRKARYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHS8</accession>
    <name>A0ABR3VHS8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_7296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1841228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55067" checksum="B4D975026A17048A" modified="2025-10-08" version="1">MSLMKFPDELLTEIAEHFVIGLLDTPEVLATVGEHDCVSDARASLVALTLTNRRFNAIATRFLYHTVRIHDLGTLFYVVSRLLEAPHLAELVREIAVTADLSLSEAYYNLWDNAGFEKLIRSLDNDNATAASRTAYTAYRQLVKPFPDLERLISTTVAGEDEDLNGLGEAACALLLLLTSKARTLYLILPDQNTGPGEYPLLTSIFDTGPTPHVLSRLEHLLLASNPAVDVTHLPETAPRDFMLGRRVKHVELFGASLMEPENSVWADVWAHVETLKMKGADTSGAWWYWLCKEARPPLKEVEISTSVYFGDAVWDSNAPGLNEALSFCTGTLQRLRLDFGESRPSDEPYLGPRRKLACLPSMKFLTHLHIPPRLLFFSMDDMNRSNICDKLPPCLQILVLQQTASICHEPNPYESVTDIEEWSWDGPKYGALVHRAVLQLAFESADCLPRLEKVSVVRSSNGCGGWTAVPELDSIVTWTSARGLKIMSFSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHW0</accession>
    <name>A0ABR3VHW0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="778"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1146" mass="126061" checksum="A5F7BDE518B61684" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ01</accession>
    <name>A0ABR3VJ01_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000064">
        <property type="protein sequence ID" value="KAL1841774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="302" mass="33590" checksum="C6AE8695C1708228" modified="2025-10-08" version="1">MNTPNSTVCVSIEANGDVSGTGIRASIYALCLGGRLLSIIAKLLSTREASAEFERSYKSALSVQGLALLCTAWYQSTQNKLTLFHAIIVLHLLSLLGVNLASRISSRGKPMVRFWLNAFIVLCAAACFLSFNIYVWVRAPDFGSQPECNDTVVYVLFGQSIKATNYVFRYFMLAALAAPPGVFILGFIIAVPCWIKIRGDLRKEGIDVPFRAAFWVSYENDDGSQRVNWTQEITQVMAYTGFSIYAIVSLEQIINRNHVNEEENEWTFGQIIALFLLLGPTVDFMNAVTDNFGRRAESMDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ10</accession>
    <name>A0ABR3VJ10_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000066">
        <property type="protein sequence ID" value="KAL1841717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="487" mass="54398" checksum="5EC279919FCE0BA4" modified="2025-10-08" version="1">MSKAQQVTRPLVRSLSHAAGTSTTCPARTLTIRQFSSTLSRSDEGSLTTGTTESASSEAQKQAADAVVIGGNNVAATTVKQGTEEELAKLLSPQLGSLRRRAALATTGNIPFEQLPYQAFQEARKILAKDREEKVAKIVAELEKIKKLEATDPSIFRSGEAYKQKRLKSMRAYVERLKILADINDPMVKRRFEDGMGTASGDMNKPIYRFLARRKWCEMDRKIIMQRITQFHIVPDLLPRFEPNMDVKLHFRRFKVPPGAILNSRITETPPTLRMQVFDAGERLISIVVVDADVPNPETDSFNNRLHYLATNIPWSPTLNSLPLSRIGADSSSSSSSSSSSSSATATAPAQPGALAVSWLPPHSQKGAPYHRLAVFVLQHSNNAPLDPNKLRELYDGAGREGFSLKSFRDNFSLTPVGFTMFRTVWDENTADVMARHGLPGADVEFRQPRVRSLKPPRKPRGWEAKRQSPKYRHLWKYTKRIKGVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJA2</accession>
    <name>A0ABR3VJA2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000060">
        <property type="protein sequence ID" value="KAL1841902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1181"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1284"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="972"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1183"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1201"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1284"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1841902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1350" mass="142522" checksum="E3468B650F3B9411" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJE4</accession>
    <name>A0ABR3VJE4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">rRNA-processing protein cgrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000058">
        <property type="protein sequence ID" value="KAL1841947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="57375" checksum="434FC3FA4C7650AE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJF1</accession>
    <name>A0ABR3VJF1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_6176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1281"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1416"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1462"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="261"/>
            <end position="271"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="300"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="373"/>
            <end position="384"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="406"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="407"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <end position="487"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="495"/>
            <end position="510"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="605"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="733"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="823"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="838"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1359"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1371"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1016"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1842010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1493" mass="161520" checksum="263EF4C67F91A072" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJL4</accession>
    <name>A0ABR3VJL4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000086">
        <property type="protein sequence ID" value="KAL1841111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF3">
        <property type="entry name" value="GDSL FAMILY LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045163153" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="419" mass="44943" checksum="CD71AA079F2C9C90" modified="2025-10-08" version="1">MSPSGFGLRRLLGLALGATFVSVATCRDHWVSIWASMPQQVELYNLPNAPYNGTDGVFEDTTIRQTVYLTQDASTIRVQFSNAFGGSDLPITAATIALPADGEAGSSAIRQDTVRHLTFSGSPSFQVPNGALVVSDPIRFPVKAQTSLTITVYLAKGQQGHAITGHPGSRTSSWLAKGNLLTAPDLGSDASVQRIDKWFLISAVQAWLPSHHQAVAIVGDSITDGRGSTTNGNDRWPDQLLSRLRTAKGRNSSLLRSLAVMNMAAGGNRILADGLGPNALGRIERDVLAHPNVRYAIIFEGVNDLGTAPATEADQTAVGDRLLLAYDQMISRLHAAGIAVIGATITPMSGPGQVYGEPAREAQRQRVNRWIRTSKRFDAVVDFDAVVRDPKNVTQLRPEYDTGDYLHLNPAGLGVNVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJM4</accession>
    <name>A0ABR3VJM4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="176" mass="18154" checksum="AD789EAC67022A36" modified="2025-10-08" version="1">MWEGDHPPPFIYIPNTHPIHDHNAVHNTNPPKTTAAANAVCTGLAGPTVGAAPELVGVNPGQLSAVEDAAAAAAVTKADAWLMMLLALASSILTLHGCATFAASTMGPSCRSGRPNSWFPTPHEGLVAFLRTSTTATGSTHVSTSFTVVGVTTGSRMGPRCASGWWSPQARATRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJQ2</accession>
    <name>A0ABR3VJQ2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000057">
        <property type="protein sequence ID" value="KAL1841971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="entry name" value="Large-conductance mechanosensitive channel, MscL, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266:SF2">
        <property type="entry name" value="LARGE-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="MECHANOSENSITIVE CHANNEL MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="Gated mechanosensitive channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1841971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21465" checksum="AF2D9F78C483ACA1" modified="2025-10-08" version="1">MADRSNRPHESSSSSEEEDQPLLEESRRRVERIVNGFIDFAFQGNVLEIAFGLIVASMFTALVTSFVSDIILPPLSVLLPLNKNLEEKFAVLRPGPNRPPQGGYNTLQQAQDDGAVVMAYGLFINKVVNFIGVGFSLYFLASMYQWISNDPIIKHTVKCQYCRKSISDKALRCVNCTSWQDGREDQFHGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJU6</accession>
    <name>A0ABR3VJU6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catechol 1,2-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF5">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASE PRCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="114"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1841645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33915" checksum="B31FF01DE6352985" modified="2025-10-08" version="1">MASDKPAHRFDPNFTDMVINGMGPNTSPRHRQVFGALIRHIHDFAREVELTIDEWMEGVKFINSLGEIYVQSNKTRNETHRICDILGLESLVDEIAHKVISETGLDPTSSSILGPFWSPNAPFRPLGGEIFQDGVPPNGRVVKMHGVIRDITTGKPIPGAVFDIWQASANGKYDFQDPENQTPNNLRGKFRADENGHYWFYCLHPTAYSLPRDGPSWALLSLMDRHPMRPAHIHIMVTHPEYQGCTTQLYPSDDPWVKSDTVFAVKDDLVVNFKPIEGDAKAVLELEYNVNLAPKGYKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJZ3</accession>
    <name>A0ABR3VJZ3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VID27 cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000082">
        <property type="protein sequence ID" value="KAL1841231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="250"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="434"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="91760" checksum="3011ED04C6113DEC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK03</accession>
    <name>A0ABR3VK03_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47797" checksum="B6F91C0908690E4F" modified="2025-10-08" version="1">MATLGSLPNEVLDAIATVLCRERAHVALRSLSLVSRRLHSVAIPHLYHHLTVPKKKWLLLSRTLVARPDLAAHARSLRARYREQRRDQRAEEEDQEVIRDPRLRAAFLKRRRAYLATLPNSYYNDDDEATPTRYNQWDLVTLDKLRYGDYNLPLDFISSLLPNLETIDASVDFGAAFRFCTPGSLPHLRSISLTYIGDCCYHGEAMRLDLVANLFRAAGGSLENVYVDNIGSCKQLTVARHKPQVQQQDDDASFDYEKEEQDDDIEEDQDEELPPLVLPGVKYVTFSGSCLLGELSYIRNILITFPNVTHLSTDVCPTCCDALPFAELGGVLRDYAPRLKSFVLNAGSLGGYGGFNREEAEGFMEGLAARGASSEIHLPERHTCGNGHIRESDVRILIEGWRQCVEKPRQGELCASVKSRPGGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL45</accession>
    <name>A0ABR3VL45_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="62344" checksum="D5E48862D4DD1740" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL48</accession>
    <name>A0ABR3VL48_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_5982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000053">
        <property type="protein sequence ID" value="KAL1842103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1842103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="240" mass="25505" checksum="6DB1BBE0A02DB9EE" modified="2025-10-08" version="1">MPVYCITGTNRGIGLEFVRQLAQSADNTIIAAVRSLSSDLTDLRAAASPSTHILECDTSKVSSIHSFAKAAARVLRDGKKINFLVNNAGVNIASHQSSLSLGPDELHTQISINVIGPAKVVEFLLDAGLLSQDVRILNMTSGLGSMQRSSEIKPRKSAGYSISKAGLNMLTVHQSEDLKPQLPDAVVIAMDPGWVKTRLGGEGATLEATESVGNILAVLHGLKPEDTGSFFHHSGDKIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL95</accession>
    <name>A0ABR3VL95_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="3">3.5.99.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000049">
        <property type="protein sequence ID" value="KAL1842246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="426" mass="46767" checksum="F2DF47E2107A0800" modified="2025-10-08" version="1">MRFIIRDDPTAASAHVANYIVDRINRFSPTPKHPFALGLPTGSTPLGVYQILVEKYKAGEVSFENVVTFNMDEYIGIPRHHPESYHTFMWKHLFSHINIHPRNVHILNGNAPDLAAECTEYEAKIRAAGGIELFLAGMGEDGHIAFNEPGSSLASHNCIKALSHSTVLANSRFFGGDSASVPRTALTVGVQTVLNAREVVVLVLGPRKALALQRCLEGGVNHMWTLSALQLHPNAMIVCDEDATLELQVKTVKYFKEIEKLAQDHDSHHPLRTTTNPPKNAMSTATTPALTTSPTNTSPEDAPDRGSTSDEHYYTYNARTTDLDTFMAHFTQEASEPRWVPDPDPNTNSDSDLDLADDDDFVPDSMSSRIIGDPNPLRRATPSSPGEGQDDDDDVDDEMMQGVAEVSVVEGTLMRPVEVSRGRGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLB5</accession>
    <name>A0ABR3VLB5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_3350</name>
        <name evidence="3" type="ORF">VTJ49DRAFT_4839</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000039">
        <property type="protein sequence ID" value="KAL1842556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000026">
        <property type="protein sequence ID" value="KAL1843036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057912">
        <property type="entry name" value="OB_CYT4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25522">
        <property type="entry name" value="OB_cyt-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="474"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1843036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112846" checksum="017FAAB70C8DFFD9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLD1</accession>
    <name>A0ABR3VLD1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000035">
        <property type="protein sequence ID" value="KAL1842693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1842693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25389" checksum="C092A371F82D89B1" modified="2025-10-08" version="1">MSQPSLPPLPANYTTALRLIDEAHAQDPRPAPSKGNEGGTDPAPFELDYAQKMTRWLAVRKPDASPELQLACRAQHFRRWETPRTNYPATRSGYLLWRARQKSQAASLVSELLTTASSSGTITPPLSADEIARVAALIRKEGITGANPDPEAQALEDTACLVFLDDQLESWFAGREDVSEEKMVGILRKTWGKMSEEGRRLALGLELGERAKELVKKALEGEEEGSDVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLI2</accession>
    <name>A0ABR3VLI2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000064">
        <property type="protein sequence ID" value="KAL1841771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046774136" evidence="3">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="394" mass="41819" checksum="A3781216928826E7" modified="2025-10-08" version="1">MARILSLIGAAALAPGALGATLIASHFSGQIYTLQYTGTNSSGTLAITSQTSGCGTMPAWIEYYGDTRQLYCFDEAWWGGGAIAEFSVGNDGRLSITGQGRSRGNTVHGALYGGPNGRSFVATAEYGPSTITTYRLPLSASTTALSQTRFTLTQRGPHPRQDAPHPHEVHTDPTGRFMLVPDLGADLIRIFRIDANTGALSPCPEARTDRGDGPRHIKFWKSASGSKQMAYTVNELGNSVSAWDVTYPSEWDTNGCLALSKTQTLSMYAPGRSGGPMTKAAEIRVVGDFVYATNRADQTFGSEQDSIATYTIDPDTGAISWLEAANSFSYYPRTFAFNKEGTLAAVGGQTSSTVAIVARDPATGRLGNLVAKIQVGQRGRAGEEDGLSGVVWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLU0</accession>
    <name>A0ABR3VLU0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000036">
        <property type="protein sequence ID" value="KAL1842668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="145"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="337"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="876" mass="96144" checksum="C4A3ECCCE87E95AE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMD5</accession>
    <name>A0ABR3VMD5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="364"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64060" checksum="31D318E21AD78802" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN92</accession>
    <name>A0ABR3VN92_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Spt3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000037">
        <property type="protein sequence ID" value="KAL1842628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44570" checksum="A18EC63DF020E9FA" modified="2025-10-08" version="1">MADKDKDKPYKYRQEIQQAVSLEEVRDLEKIRRLIEPWLGRQGVPLHHLKHAFMIAHGLPTPPHDVRTRSEPRPRETIANYLMLKMMYVSGETGEPSVETTCIIEDIVRQQVIEILRNCTELAARRGSRSITINDLIFQIRDDAPKVSRLRTFLSWKDVRKNVKDSDDKGGEADLGAAEDPVGGVVAGGPVDDTAKKNKKAKVGLPWEPASFYSVEVPEREDEEDEEEEEMNYITLQRLRKADERTKAMTKEEYVTWSEYRQASFTYRKGKRFREWAGFGIVTDSKPSDDIVDILGFLTFEMVQTLTEEALKIKENEDLHRERTGENAGKKRKLPGGGGLFDPPSEGRTPVEPRHIQEAFRRLQQRPKKSRAMLNGTRLQQRTSLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNL0</accession>
    <name>A0ABR3VNL0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="94518" checksum="F93BE8291B04DC7C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP13</accession>
    <name>A0ABR3VP13_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045909906" evidence="2">
        <location>
            <begin position="20"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="700" mass="70550" checksum="AA5AB679EE9C40C2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP71</accession>
    <name>A0ABR3VP71_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Increased loss of mitochondrial DNA protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000016">
        <property type="protein sequence ID" value="KAL1843437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22774" checksum="039B4766B7C16BE6" modified="2025-10-08" version="1">MALISAKTILTSLCLFHLTLGFFFLTRPASVAEQPLVYVLGESMGLPGSRAFEQPSPALGLLAAVLALVGLSDLATLSLPDEVGLVQYWGMQAPLRLTITFSLALYSFFFSPSSPLFYSSRPDETSSSSPLTHPTVHRAQHNPAYSPSGWGGDALKNRVFFSFMFVEAISWFWAWVTLQEERREVLAKRERRRRRSSEGGGAYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP77</accession>
    <name>A0ABR3VP77_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="289" mass="32099" checksum="61BCC562266A7E42" modified="2025-10-08" version="1">MFSRRFEQPPNSSKSFSKSSSVRHRRASSSFSKEAGITKRPSESGRRRAGTVSNSAAASETTLGGPVSAIVTLIVGQEQRIFAAHENVLSASPFFQSVLQNQMMDAPTKKISLPDEEPEVFSSILEYLYKGDYYPRLVHNKKRNTWELEEAGEDGRSEATIYHHSVEGELLKDTAIYCAAEKYGLEELKRIALRKQGLQSGIQASTILASARYAYANTPDTDSKLRAHYLALIIRSRSTFKRSGTMQLEMFNGGTQLFFDLFVALCNHVDDISNAATASPRTPRSGRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPF0</accession>
    <name>A0ABR3VPF0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_3183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1843048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="173" mass="19626" checksum="6FFCA6B3F988BA13" modified="2025-10-08" version="1">MSCHMTSNSKRLTDAATNTADAAAEHRGVPKIPDEVGLMTRLGPSGRDWYDKRYQAGQFLRRLPAKIDDRVRRELEDLFHEKAAANIRDLIHREEAALPHVHSAAEALRRELDAMRGRWIEAVLKHAAGVGLDNNKDTWQALRRASARANGEAFDVNQVAPDWRWLRRCGHSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPM6</accession>
    <name>A0ABR3VPM6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000017">
        <property type="protein sequence ID" value="KAL1843400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="325"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="518" mass="57772" checksum="8C5ECCB000D64177" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPR5</accession>
    <name>A0ABR3VPR5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="530" mass="55663" checksum="14C03C4F88F6CFA9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ70</accession>
    <name>A0ABR3VQ70_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_6850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000007">
        <property type="protein sequence ID" value="KAL1843907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="9"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="273" mass="30348" checksum="8A313FD8C3BCFF10" modified="2025-10-08" version="1">MPKAPVYFFSHGGPDVQYNTKHPVYPVLQAIGKEITQKVKPKAVVVFSAHWQAEPNKIHLNNAEDTDLIYDFYGFPPEFYKATFPSKGSPELASRILNLLSTAGIRARGLKRGLDHGVFSGFNVAFSPESNPLNCPLVQVSLFNSEDPHAHFRLGEAVAPLRDEGIVIIGTGMTVHNLRDMRFAWGKPEPLPYAVSFDNALKEAVEADPAVRKERMAEILKRPDARQAHPWMDHLMPVYVAAGAAGEDKGVQTWTLHEASFAWAQYRFGEVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQT0</accession>
    <name>A0ABR3VQT0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="214"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1844274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="463" mass="50135" checksum="99C4AFB21D0CFDC8" modified="2025-10-08" version="1">MATFESLHERLSTLQETASQLRELIDRLANLRFEPGSVPLPADGTDSSDNVATELSAEIAQTLRDEEDDLELLREEVADLPPARPGSDAEQRKTRLRDAAATLQADLNRCRTDFRKAQLAARRSLEAAQKRERELLLASYAATASPSPASSTILTRPGDSNGNNSPDPNTTKPPQAQLTPEEARAQLFRRRHRKPSIPDASSSSSPSSSAAVQTSHDVTLALQRTHALIAGEVAKSAFAARTLAESSAALAELQRSYEGVEGLLTRSRELVGALAAREKSDSWYLAAALRILLATLAWLVFRRFLYGPLWWLVWLPVRTGYRVTSGVMVGGGGKGGSSSSVGATMGVVQPGEGASTVVVGVGEEGAVPTVRVGGRERGETGGDAEYPMVEKVGRMVEDTLDRRDADDEKENLTGTEEPEPEPEEEPAEMQKEEEYKPNPKKRMWEEPIGQEAAGGGQEVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR11</accession>
    <name>A0ABR3VR11_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000002">
        <property type="protein sequence ID" value="KAL1844266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="178" mass="19541" checksum="77A217000D6F2002" modified="2025-10-08" version="1">MGQDEKKRPAALNLAPLRTKSASSVSSNESSSTSSSVAKPPRTPRFAEATTVHSPIDHREQPFSEKSENGQAQPGDVGFGYIGQNGQRESVAVPMTPRSPLKSALKVPGTPGRALNPLSPTFREEQALEDREKKTDKEQARDLVSQGPRHEEEGRRVTNSRYRKSRRGYEWPSSLCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR56</accession>
    <name>A0ABR3VR56_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="238"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1844157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="374" mass="40568" checksum="4A5B6C708F07C07D" modified="2025-10-08" version="1">MSARNRNARGPNRNSGTTQGEEAHLWSQIKDDIRAMIDGVNSSNDALRAILAQDSHIAKNKGSIDVASEEQKLDSLLRSGVKGSDTSKQQIDALIEHVTVLRALVKAREDAEAQTAGPSGLGGRERTGGFLSATGRTGSMRGASAREKERERERERERERERDRDRDPGSVYEFDASGDSPVPSPVGRKLGGSAGAGSDRSANRDSVPPRAGDRDTPGKADSVPPEGGGLAGTMAQRAKVTFFKGQDVVFKPKPTTTTESTEWMLGKVQQILGDGKTRRYKVQDADPDLPPDQRVEYRTSASSMIPIPAAGAELPELEKGKTVLALYPDSTTFYKAEVMGTDPGTGKVRLRFEGEENNVTLQLVERRFVVEYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRL4</accession>
    <name>A0ABR3VRL4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">VTJ49DRAFT_3874</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 12"/>
    <dbReference type="EMBL" id="JAZGSY010000003">
        <property type="protein sequence ID" value="KAL1844218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1844218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="556" mass="63621" checksum="95AB76BBE8047094" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRN0</accession>
    <name>A0ABR3VRN0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">VTJ49DRAFT_4978</name>
        <name evidence="21" type="ORF">VTJ49DRAFT_7535</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 620.91</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="de Vries R."/>
                <person name="Natvig D."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Preautophagosomal structure membrane</location>
            <topology evidence="3 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000090">
        <property type="protein sequence ID" value="KAL1841019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="733"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL1841019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAL1844126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="903" mass="101683" checksum="1EFA795AB0F21502" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V187</accession>
    <name>A0ABR3V187_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000638">
        <property type="protein sequence ID" value="KAL1835491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045517016" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="50"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1835491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="618" mass="69372" checksum="83F1CD26E52F621D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V195</accession>
    <name>A0ABR3V195_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000618">
        <property type="protein sequence ID" value="KAL1835529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023:SF1">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="724" mass="78286" checksum="0876E7FB5D6BAB47" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1D9</accession>
    <name>A0ABR3V1D9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000600">
        <property type="protein sequence ID" value="KAL1835574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="222"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1835574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="554" mass="61106" checksum="1A42C31115C5D0B5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1F6</accession>
    <name>A0ABR3V1F6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_6741</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000670">
        <property type="protein sequence ID" value="KAL1835427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1835427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="473" mass="53360" checksum="4CE69EFD7B9A5AB5" modified="2025-10-08" version="1">MAESTPAASAPPPADAAAPKAPPRNPALRMLGLPGLPRKLPSRNWMIFWTVSGAITAAIIYDKREKKRATARWRHAVEHLAKEPIPDGLTQPRKITIYLSSPPGDGLRVAQDHYTEYVKPILAASGLDWEFVQGRREGDIRAFVAERVRRRRQTLDNGGEPPETDKEPTKEEIIEVFRKSRGIKEYDGIRGDVVIGRHTWKEYLRGLHEGWLGSLTPPPEPEPKPEPPKTDAPEAATDGKLAGEDKAAEEKKAEEKKEEEQKKPKRPPQPRPHNSPADYPTASLPAVIPSAFDPSAPIREPHLLGFLNTPTRLYRFFNRRKLADEIGREVAAVCLCTYREYRQLDATAAAGPDDASPTTDASSPSPQYEQQTELVWEEKDWVKDLWKESADGPTDEIPERVRAPPVVMDPRIAARMRRFHLTPEDEAKARAIVVPEEEIEGWIKGKFRQLYRWGVRKAFEKKKLTPLDDKDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V1Q0</accession>
    <name>A0ABR3V1Q0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000574">
        <property type="protein sequence ID" value="KAL1835656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1835656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="93" mass="9865" checksum="09735264AFC9DEC6" modified="2025-10-08" version="1">MASTPTMIATHQASAPVNSLTTKRHLKPSKMITTLPLVMDDMVPVNPDGGTIRDGIIFPDNGLDLAPKTGKKDDPVDGDGDESDSDNDSDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V234</accession>
    <name>A0ABR3V234_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CoA-transferase family III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_6677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000656">
        <property type="protein sequence ID" value="KAL1835456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1835456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="87593" checksum="127A935588F614E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V2L4</accession>
    <name>A0ABR3V2L4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000528">
        <property type="protein sequence ID" value="KAL1835832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1835832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="443" mass="48163" checksum="D986E14502056987" modified="2025-10-08" version="1">MDAQEKRNIVIVGGGIIGCSVAYFLTRHPKFNPALHTVTLLEATSIAAGASGKAGGLLALWAYPKSIVPLSYRLHKELADEHNGAERWGYRRLGCGSISAIVREKDLDARTSKPPPPPQTSSDADGELPIQSTLKEETTKDWEKLPKQDDNATALLQDSPLPKDLDWIDGNLVQFYEEMGSPGATETAQVHPFHFTNAMADLAKEKGVDIRLRAKVTKISQGPSGTHTVKYEDRDTGTVHSIDDATDVVVAAGPWTGKLLPRTRIETLRAHSVVFEADVSPYAVFTDIQLPASYVPEHRKEQGQKRRHKGSVDPEIYARPFGEVYACGETDTQVPLPATADLVEVNESQCDDLIAYIGTISPTLAAAPVKARQACYLPQHIRFGEQRNPLVGPTSVPGLWVAAGHTCWGIQNGPGTGYLMAGMLFGDEVDGEVAKLDPRKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V302</accession>
    <name>A0ABR3V302_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cdc37 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_5529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000457">
        <property type="protein sequence ID" value="KAL1836153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="355"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="179"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1836153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="461" mass="53492" checksum="9783FE9709CAF116" modified="2025-10-08" version="1">MEGFKSYKDQTVIEPFSPGTNVIVGRNGSGKSNFFAAIRFVLSDAYTNLSREERQALLHEGSGSAVMSAYVEIIFDNTDKRFSEPGDEVVIRRTIGPKKDEYSVDRKVQTRADVLKILETAGFAKENPFYIVPQGRIAAITNMKESERLNLLKEIAGTNTYDDRRIQSLKIMAETNSKREKIDETLAYIEERLKELEEEKDELQLRTKNAQLDRERHNLETALQRQAQVERNLKDLDDSITAYQAELTQDFKKALTASEERQLEEFTTEVHRLQRELKEPEQIESRLRKVNEALKKYKHINKKAFDQYNSFTTQRDQLLKRRKELDTSQKSIEALIEHLDQEKDEAIERTFKQVKWDALELSDDSDIEVHPNVDKRSFIRAKQHQIHMQRQERRHKIETLKYERIINDTLIKRITQLHESLKAHAAEAKAGNPGEVAFRVVMQSAASLDPKDDQPPPRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V391</accession>
    <name>A0ABR3V391_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000446">
        <property type="protein sequence ID" value="KAL1836212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1557"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1469"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1601"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1710"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1755"/>
            <end position="1764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1828" mass="201028" checksum="5B0CAF0983667B12" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3L8</accession>
    <name>A0ABR3V3L8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5247</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000423">
        <property type="protein sequence ID" value="KAL1836355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="386" mass="42468" checksum="671461E8403AA955" modified="2025-10-08" version="1">MAPISHRGYQLAVVNITALALATTATALRCYVRACLLKAFGPDDWLMLAASVSFACYCSFSLLGISHGTGHFVADLTTEEESTARKWWWHCYFAYALTMLCAKMSIAFFFSRITVRRVHRYVLIVTTLFTLISCFAFFFACIFQCWPVSYFWDKHTQSGKCIPNRIIIALALLFSVINLLTDITFALMPAWIVSRLNMKLKTKLALVALMGLGCVASAAVLVRMPYVHLIGSDEFLHDSFHVAIWSSVEEGLAITAGCLATLQPLVKQIAYKFGLRSHPSVPLGESDDYANSRMNRAAISVRTEFTHHAETLVDMGDGQDARSGKGGAPQLPLGVIAYSAAGYSTSEERLRDTTSSLDDESSKGGERGTASREGRSKIPTAIVRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3Q4</accession>
    <name>A0ABR3V3Q4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_5604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000468">
        <property type="protein sequence ID" value="KAL1836081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="337" mass="37202" checksum="DD27CD980012941F" modified="2025-10-08" version="1">MAPKNPKYNDLEAFHARLRRSRRILAVCGAGLSAASGLPTFRGAGGWWRNYEAMKLATPEAFERDPGLVWLFYAYRRHMALRAEPNAGHYALAELARQNPDFLYLHPRAGHPPEQLRLLHGNLFTLKCESPTCDYTETNLDSPLCPALAPAAIDAPADPAVIHPVLDPSTPLPTPSRSDLPHCPRCSSSSSDSPKRGDTPLLRPGVVWFGEQLDPSILSYVDSWIASPTNPPVDMVLVVGTSGIVYPAAGLAELARSRRRGRRRRGRRRGGEQAGQNEDEEEETSVVHINLDAEAPETLRRLGPGDFAFAGDAAEVLPRLLEPVIGRWDKEEKRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V3U5</accession>
    <name>A0ABR3V3U5_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000435">
        <property type="protein sequence ID" value="KAL1836290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="300" mass="33477" checksum="48ECBE995BB152CF" modified="2025-10-08" version="1">MTEATINVPGQVKGCRECVRGSGGLGHVIHSRLGGKRGRCWPGLVGRLSYNRYTKIHWGGGFGCHHADDRLYRRASSLPLLQNPRFPLYVGRHQEKPSFPYPFHLQLILRRIRRLRHRHSRGLVALAQHFRVLVHAGIQPQPNSAAHHLGHLSLVDGPQAGQGRVLDAAHGRDELGDEGEVLGRQTVASAHTHLPLLTKPDDPEEQQEEEETNLVIIHRLKPQQIHHIPRRAAPPPPLLHLDRLEIPRRIHLANLPPSRHLPQVCVRRGRPLGVLGHRPRGRAAAGPGPELPQRAPPLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4M6</accession>
    <name>A0ABR3V4M6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_5418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000445">
        <property type="protein sequence ID" value="KAL1836223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF5">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="54"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1836223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="434" mass="47128" checksum="773B78D32134AA11" modified="2025-10-08" version="1">MVLEITRKASLLARLAAHGLRLACSSLRRVLSTQWASLTMRRPSVPTHPSEVKNVVVAGASFAGYFAARLLATSLPKDGRYRVVVIEPNSHFNFTWIMPRFCVVGGHEHKAFIPYTPAFFSQAPKGMVRWVQDRVTGVRKNAVVLRSGDEIPFEFLLIATGSTMANGLPSRVGVEDKAGGIERLKSMQARIREATRLVIAGGGAAGVELATDAKSQYPDKSVTLVHSRQAVMSRFGPGLQKSAMEALQKLGVDVVVGEKVQAPTADGKFITLSSGRQLECDCLINCTGQKPASGLVAEIAPHALAPSGRIRVKPTLQIDDDSLPNVFACGDVAETKVSNQNARTSARQAEVAADNIVQMARGRVPSYTYEPAWQDEVISLTLGLGQSITEIWDGRAELLFSRPEKDLAPMCERAWRSLACKPFEDTGVYSDHQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4P4</accession>
    <name>A0ABR3V4P4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_4711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000370">
        <property type="protein sequence ID" value="KAL1836752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="205"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="205"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1836752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="489" mass="54202" checksum="B558FDD7D1F1EC70" modified="2025-10-08" version="1">MPPPNTPVDGTTTPQSTQPSQPAQSSQSSQSVSRPTSSIIMDASQVKTALVKMDYQAIDYVNPVDETLICPICRTAFHSPITTPCGHTFCAKCINRALERQRVCPIDRQPIDKTRDYRPIPLIIKEQLDRLEARCPNQGCDYVCARENLEAHYERHCEFTLVHCSKPSCDKLVARHLCSIEGQCMHEMTNCDFCLKPVAFVDLDAHWEQECEAAFATCPDCDASVSVVNNSMLKHIQQECPEAMAKCKWDGAGCRVTDKRRIVREHERNGCMYETVGRLLEQQAEDRRIIQDLTRRLASLEAVRDTRRRERRRDSAATINDRTATATAAGGSLTNPTTSTSTPADSTTWESPHNYMLAQFERLESHMEELREMVCEMDMRQSASFLHHSKQVADRFLELGDKVGVLSMHTKWLLNMQYMQRNAQLRAANAASLAAAAAGAGGAGLSGGSDGLNHGGESSSGAGSSSDSGLRYQGSRRGSEGRIENLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4P9</accession>
    <name>A0ABR3V4P9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Stress response RCI peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_5162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000413">
        <property type="protein sequence ID" value="KAL1836426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="chain" id="PRO_5045909891" description="Stress response RCI peptide" evidence="8">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17942" checksum="BF1D7312D580DEAF" modified="2025-10-08" version="1">MCSTDCFLVLLAVLFPPLPVWVKRGICSADSFINILLFILGYLPGLLHAWYIIARYPDPYFDPTYQPIHDAEHGHGQGRIYVFVPGHPSAPPQYQQPVPQGPMNYGTTSTPAPAPAAGSRAACDAHCQQHHAPQEQGTTAAAGPSDGSAPPSYAQVVAGDHKVQSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Q8</accession>
    <name>A0ABR3V4Q8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_4698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000369">
        <property type="protein sequence ID" value="KAL1836758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045713488" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="79"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1836758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="444" mass="50403" checksum="4581FBDDA6DAF37B" modified="2025-10-08" version="1">MTRLSLTRVFVLGLLAPLARAEGSQERADPPLAGKDDGLAYEEIEKTTIYTDNATAPAVHLPPVDGWWDSKICSSDENYCVFTNRRAAKGRGIVAVTRPDELEKLEKLEEVINKSENRYLIDDPESTLQEKDLPEYDGLTGLVATKALRRNKPLFAWTPVLFAHKQMFQKGGPKKKDRTRLLEAAVGFLPPHTRAAFDKQRRRPGDNSGLNPRSIEEILKAHPWEVDLGVNWNHRDPDVHSRHYVNFPEASVLQHDCRPNTAVYIDSKFTLRATVARKVNPGEALTVSYIDPFLSRKERNAFVRKYRAPRGPDGKPTHGCRCSACSGPDKDKHEERLKELLELRGELRNHDSRKVDFALIERFVKLVEEEGLHARYAEPYELAALNFNYYGDDKRAKKYADKAVQAGIVEGGLESNDVVAMRIMANDIKGHYSYRYNLKRRGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V4Y8</accession>
    <name>A0ABR3V4Y8_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000362">
        <property type="protein sequence ID" value="KAL1836820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF66">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="35"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="576"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="675"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="758"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="839" mass="93594" checksum="8DE122B832B30D6E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V587</accession>
    <name>A0ABR3V587_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000348">
        <property type="protein sequence ID" value="KAL1836932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1145"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1757"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="712"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1071"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1585"/>
            <end position="1751"/>
        </location>
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        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
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        <location>
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        <location>
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        <location>
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        <location>
            <begin position="759"/>
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            <begin position="797"/>
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            <begin position="997"/>
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        <location>
            <begin position="1706"/>
            <end position="1724"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1836932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1974" mass="216614" checksum="31F6FDD40E6491C7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V591</accession>
    <name>A0ABR3V591_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000348">
        <property type="protein sequence ID" value="KAL1836929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
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            <begin position="172"/>
            <end position="195"/>
        </location>
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        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="38"/>
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        </location>
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        <location>
            <begin position="379"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="EMBL" id="KAL1836929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="449" mass="48671" checksum="3D92AB7A8484005B" modified="2025-10-08" version="1">MEPMVPSTPTRGRTARPRTPTAPQHGFEDNYEPYSPRKSTRIARRAANRTPSPPPAREKSSQQHNSFGSPKSTKKRLPPTMATPALSPQKKRMPPTDSSRKASGTLTIESAANAAVALGLSPAPKSEPRSSRRGAASGAGMLITPAKTPQKPPNEKVTAKVKSVARNLFHDDAEEAIVRSPKKMASPTNNPDSFYCGEAAETSFEIFTDSHERIPEVDTSSDNPFYVTQTTAPPEPPRRRSKRNLVTIPGEGKVTVEEAVRREDGMLIVFRGKKQFRKFADVEEPTTRQGLDDGEGGLEGAVESPTKRHFTRSSIKPRLLFPTSSQDDESNSLDDEEAATDIEDHVLASLQEEDAEKPETPNDLIDEAAPGTPPRAPRHAPASPPTTTRTTRFGSKKAAEPTPKPKPPAKRSPFDSWRRVKGGATAAETSGLKRSGDELTAAGAKRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5M0</accession>
    <name>A0ABR3V5M0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_4742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000375">
        <property type="protein sequence ID" value="KAL1836716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1836716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="620" mass="68835" checksum="DF2A92EB1B9A0517" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V5Y8</accession>
    <name>A0ABR3V5Y8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_4193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000322">
        <property type="protein sequence ID" value="KAL1837163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="179"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="277"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="463"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="560" mass="63143" checksum="FA1C970E3FA055A5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V618</accession>
    <name>A0ABR3V618_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="7">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_4202</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="7"/>
    <dbReference type="EMBL" id="JAZGSY010000323">
        <property type="protein sequence ID" value="KAL1837156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="11">
        <location>
            <begin position="77"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1837156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="269" mass="30168" checksum="EE6406EB706593F1" modified="2025-10-08" version="1">MSSTAPPTANGDATIPDVGLVPNAGPTLNPWTVEKVLETFPTGKPAEGTSSPVPYFHLLERLKTTKREGWRRFGIERGESISDHMYRMSMISMLAPPSLTSRLDLSKCIKMCLIHDMAESLVGDITPVDGVPKPEKNRREAATMDYITRQLLGNVEGGRAGAEIRAIWQEYEDSKTLEATYVHDIDKMELLLQMVEYEKRGRGKLDLGEFAYVRTGIVLEEVGQWADEVMRERESFWAGKPHIRGELESEEGGVETDKKAMQDAYYGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V640</accession>
    <name>A0ABR3V640_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_4106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000316">
        <property type="protein sequence ID" value="KAL1837224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="302"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1837224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="546" mass="57833" checksum="8DE442447051598B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6L8</accession>
    <name>A0ABR3V6L8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000303">
        <property type="protein sequence ID" value="KAL1837351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="6">
        <location>
            <begin position="44"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1837351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="274" mass="30833" checksum="3681565B334F7A72" modified="2025-10-08" version="1">MQATRSLLYKGFIGRSVDEFKRLSHIVFSLEGIKGATTPYEIHNFHTPESIGDCKLMSDQEIGGFSSANMEWVKEENSTNGGPAGYARFYGSISTKLPKDRPDVKRTGYAAFRTKDRPPTIFGRSLHNIDPYAYLALRVRSDGRSYFVNVLTESVVPTDLHQHRLFVKRPGHWETVLIKWNDFVRTNYGFVVEPQTEILRAKVKSVGIGLTDRIPGPFELCIERMWATNDESEADVVVDLTAGSAENEEAAPAPVQREGMLKTKEGKKVSWDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V6U3</accession>
    <name>A0ABR3V6U3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000290">
        <property type="protein sequence ID" value="KAL1837484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24442" checksum="69E362C3433FA5CC" modified="2025-10-08" version="1">MNRIALPPARLSPLLHRLLAAETRALTLNRHHAPTLRLVLSRPVSSVAEVSFWKSLVPKPLRDRTVTGKAKVQAKTKKDWNPATFFIFIFLLIGSMSIQMIALRRDFSTFTRQADVRIGLLREVVEKLQRGEEVDVERVLGTGDPEKEQLWEQVLRELEREEPVKQPRKKKQQQQQKQPEPEPEPAQASEPATPSTPEKSQAAPLQSTLASKGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V707</accession>
    <name>A0ABR3V707_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000282">
        <property type="protein sequence ID" value="KAL1837563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045045013" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1837563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="220" mass="25166" checksum="4A845BE81B8C8816" modified="2025-10-08" version="1">MARLPSLLQHFCSMLLLLAVGSHALKFDIQAGNGHDKHSRRCIRNFVSRDMLVVVTAIVDGYRGDGMQLNMHILDATGNEYGKPKDIAGEQRTVFTALADAAFDVCFENVLTGSRYIERPFRHVELDIDIGADAKDWSAIQATEKLKPVETELRRIEELTAEIVAEMDYLRAREQTLRDTNESTNTRVKWFGLCTTFLLIALWAWQIMYLRAYFRSKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V859</accession>
    <name>A0ABR3V859_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_4059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000311">
        <property type="protein sequence ID" value="KAL1837273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1837273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="220" mass="25724" checksum="12677DA117F90089" modified="2025-10-08" version="1">MSSYYYRDTIINSGWEPPDPTRLDILGGLLGRTGYPAEFRVTIRTPYGLIVEASSEGPYNIRLDDPAAEPKPDMEVLQGIRFFIKPNEMTDTCIQFEEAWKGNMEHGWYGGETPEQVLRERYSEAWCNALMAWAEKYKTANMRYNKYGREDTEVFPDRAERIQFHMEGLLLGAWLALQPGVNGVKYESYGRDKRYVLVHNYLSEVFEEYLNDLHRRELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8D1</accession>
    <name>A0ABR3V8D1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_3127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000243">
        <property type="protein sequence ID" value="KAL1838033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF162">
        <property type="entry name" value="SATRATOXIN BIOSYNTHESIS SC1 CLUSTER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="50"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="417"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1838033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="87282" checksum="21DB884A4064D87A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8P9</accession>
    <name>A0ABR3V8P9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">VTJ49DRAFT_2966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000232">
        <property type="protein sequence ID" value="KAL1838185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF46">
        <property type="entry name" value="FUMIGERMIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="928"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2604"/>
            <end position="2680"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="928"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1407"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL1838185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2723" mass="294479" checksum="87DDFE9EFECA29E3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V8X4</accession>
    <name>A0ABR3V8X4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_3666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000284">
        <property type="protein sequence ID" value="KAL1837543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1837543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="462" mass="50855" checksum="90410B754F9B406A" modified="2025-10-08" version="1">MASNYPAYGTTEDWSYPPAESTSTGYDPVYQTIDPAYLSAVPPRPSDYAAYYSSTEQAAATTHYYQYPDATSPVSQSAWPQDQETTPPPASSLLYCPYEGCSAKPFTRKCDLDKHYHNHTKRRKCDLCSKGGAETKDLNRHMWTHHPDEARRRGVPREDAVCEKPLPLSPLKGLDQPIPHPFTRLETGTYLHDRPIVDVYRILIDAYRLRLDDDRRIAGLPTDDATYLRTPATNPTEQPKLEPPPPHESGQRLSGFQRFLTLAASRPGLLPDWWTPNKQRECACLALSGALGWQDLLCPVGKAEVKEYYGDGSFVLQLRMLAEMVYGWGPGGEDWTAFRRIMAEMESGEGGPFPITTSIMRITSVFLLAAMALTGAATPASNDPGHALFGRACVSNGCQCVSGLKQGVYCGNCVVGAGTYAIKTKRVKNHAYECNPRGGCCDYGVANDCGTSRARCKMGSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3V9C3</accession>
    <name>A0ABR3V9C3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_2657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000214">
        <property type="protein sequence ID" value="KAL1838434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000182">
        <property type="protein sequence ID" value="KAL1838966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1838966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="390" mass="43685" checksum="6D9E041744660B22" modified="2025-10-08" version="1">MDIDPNDINNFLRGLPKKKHHILSGLHSAASHRATRATAEGNSSEDDVMYNSDDERVVLSHVEDASGGDAPSEYTAYSASASTVLTRSTAVFSGNGSRVETSTCYSVPVSHPGGPVGPVEDFSFFTQHPDSSAPVHDQDSDQDAYSAYAGETGQYPYQYQYQHDPQAYHSDDDDGSEPVLWCEFSQTLNCPRTFPMTDVAGWIRHHEVDHLRSRPPGHVICWFCDEHSFTSPFHDSSSKNTRSSKPKPKPKPKPKKPIDSKAKKQAASANFAARMHHILTHIHYGATPGTMRPDASVVKRLRKLEVIDEARYQELRTYSEVPAQFVHPDARPRLAGSAAGAAGGLSALAEEGDGRQSSPEEYQRFQRELRERRRRERDEENRRRGERRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCB9</accession>
    <name>A0ABR3VCB9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CLU1</name>
        <name evidence="2" type="synonym">TIF31</name>
        <name evidence="5" type="ORF">VTJ49DRAFT_1926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000179">
        <property type="protein sequence ID" value="KAL1839026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="334"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="926"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1302"/>
            <end position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1839026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1313" mass="144323" checksum="50583AFD8EB6CBE2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCI7</accession>
    <name>A0ABR3VCI7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAZGSY010000158">
        <property type="protein sequence ID" value="KAL1839419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="853"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="856"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1143" mass="124181" checksum="3E3DDFDD8959636C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCJ0</accession>
    <name>A0ABR3VCJ0_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_1395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000150">
        <property type="protein sequence ID" value="KAL1839574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1839574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="486" mass="52721" checksum="AD041A96832E347A" modified="2025-10-08" version="1">MTPTGSHVLPRDAGPGTDGNLTTGAIAGIAGGTGALFLGAAGLFFIYWRRQRQFDREDNSDVENLDYHNHHQQTGRQRAMTAPAVAYTMDYKHDDPQHYEGATLGGEPASSSYIYSPERGAYTLSPLGSPPDSASAMPTHPAYIPRALVRGASTPSTLSRSTPTTSPPPFPSPPYPGPQSSAPKTQADDTVIQAFLRAAGGEAEAGGQGTQNFASFSRSRQPPPPPLNFSSTTPNTTSTTTQLTPPSQQQQQQQSPSNFQPPQARKPRTYIPPPLNLNPIITTNTRPSPPATPAGPSVAAGTLPRLPGGDKPLQGREHTTISGPLAFPELHPHHAPTKKKTARARRGTRTSRTRDDVFDYDDDDDDDDDDDDGDDDDDNDGYDETTYTDDEYDPDKKPKGGYAEQSYHRRQRQRQRQRSRSRRRSGGGGGGNEKRTFRARALSRVDDGDGDREKAKKHAKKRSDRNSGGGGRHYAEIEVGKGSDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCK6</accession>
    <name>A0ABR3VCK6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_1600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000161">
        <property type="protein sequence ID" value="KAL1839365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1839365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="111" mass="11813" checksum="B15F4EE57AE42EF0" modified="2025-10-08" version="1">MDPDVATGVGGGLTQSIPRRALFASVVGNHIFVAAPVCAPWPNAESEGFNAPAQVDDIAVAALHQLFLKLCLTDDPYPMSIVSTDADCKAASRDTPDDTIIEIRQATMRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCM1</accession>
    <name>A0ABR3VCM1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">VTJ49DRAFT_1487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000156">
        <property type="protein sequence ID" value="KAL1839449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052025">
        <property type="entry name" value="Xyloglucanase_GH74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739:SF2">
        <property type="entry name" value="OLIGOXYLOGLUCAN-REDUCING END-SPECIFIC XYLOGLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739">
        <property type="entry name" value="XYLOGLUCANASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046854550" description="CBM1 domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="9">
        <location>
            <begin position="804"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="746"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL1839449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="840" mass="88399" checksum="79CECA8389FBE04C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCM5</accession>
    <name>A0ABR3VCM5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UV-damage endonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">VTJ49DRAFT_1418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000151">
        <property type="protein sequence ID" value="KAL1839555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL1839555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="70458" checksum="62F391B29566AE99" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VCR0</accession>
    <name>A0ABR3VCR0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000165">
        <property type="protein sequence ID" value="KAL1839297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="152" mass="16870" checksum="68C1B8F28F817DEE" modified="2025-10-08" version="1">MALPKRIVKETERLMAEPVPGISAVPHEDNLRYFDVEIHGPSSSPYEGGVFKLELFLPDDYPMAPPKIRFLTKIFHPNVDKLGRICLDVLKNNWSPALQIRTILLSIQALLGAPNPDDPLAADVAKSWKEDEQAAIATAKAWTQQYAVPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD29</accession>
    <name>A0ABR3VD29_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_1271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000146">
        <property type="protein sequence ID" value="KAL1839661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="63"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="711" mass="79050" checksum="96EA9C432F183700" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VD60</accession>
    <name>A0ABR3VD60_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription elongation factor SPT6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Chromatin elongation factor SPT6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">VTJ49DRAFT_1632</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OSBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000163">
        <property type="protein sequence ID" value="KAL1839336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
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                <person name="Tsang A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Mondo S."/>
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                <person name="Conant G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1839924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="381" mass="39153" checksum="054FC93E6D91905E" modified="2025-10-08" version="1">MVTATFYSEVKRLYTSLQDLVGLRRKKRSVVISEPFNFRREPTVLPGLTEDELVVLSILREKAAASRLGIAHAIDPSRAATPTLFPTAPHRRLAKRRSGSGPLTSSPPSHPLGGTPSSSTLSLPMMMTMPMPMPRLEVTAPNPPTPPRTPTPSSSLMMGGGGGKVGPIPIPIPGAGMEGGGGRYVAGKNMVEGSSSSWRSGSMSGGGCGCAGSDAGSDAGVSGGGGEGVMTGSPRKGAREVVPLSATATDLEMLLFGNPSGTGSITNTSSKAGVAATTAAITTATTTTTRCAGTPTKQAGIDNGVNEITSTTTDKGREDRDLPKLVMPLPSTATTDMIPSSLSSDMVSPLEEARVADCWDMDFEFQLGSPVSPLSPRPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDQ1</accession>
    <name>A0ABR3VDQ1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phospholipase D</fullName>
            <ecNumber evidence="2">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="2"/>
    <dbReference type="EMBL" id="JAZGSY010000133">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
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        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="1208"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="560"/>
        </location>
    </feature>
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        </location>
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            <end position="1424"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1693"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
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            <end position="109"/>
        </location>
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            <end position="192"/>
        </location>
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            <end position="217"/>
        </location>
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            <end position="236"/>
        </location>
    </feature>
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            <end position="556"/>
        </location>
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        </location>
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        </location>
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        </location>
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            <end position="1711"/>
        </location>
    </feature>
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            <end position="1722"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1839960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1862" mass="207757" checksum="0069DEF8A387F82D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VDW4</accession>
    <name>A0ABR3VDW4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000129">
        <property type="protein sequence ID" value="KAL1840054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1145"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1305"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1840054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1363" mass="146921" checksum="CBB394682E848B63" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE31</accession>
    <name>A0ABR3VE31_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000153">
        <property type="protein sequence ID" value="KAL1839508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
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            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
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            <begin position="132"/>
            <end position="596"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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            <end position="12"/>
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            <begin position="16"/>
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            <begin position="81"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1839508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="639" mass="69141" checksum="A16402A24CB0AB51" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VE82</accession>
    <name>A0ABR3VE82_HUMIN</name>
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        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">VTJ49DRAFT_747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000124">
        <property type="protein sequence ID" value="KAL1840173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="567" mass="62114" checksum="8E069C94456415E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEC0</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Humicola insolens</name>
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        </lineage>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
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                <person name="Otillar R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 620.91</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C2_Mug190_3rd"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SMP_MUG190-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="13">
        <location>
            <begin position="253"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="478"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="667"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="702"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="873"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1112"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
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        <location>
            <begin position="1151"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1210"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL1839756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1263" mass="139600" checksum="144214DBB7A01321" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEM3</accession>
    <name>A0ABR3VEM3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_1047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000137">
        <property type="protein sequence ID" value="KAL1839861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="854"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1232"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1036"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1160"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1208"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1297"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1839861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1404" mass="153533" checksum="785C3F9C26A51D7D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEN9</accession>
    <name>A0ABR3VEN9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="JAZGSY010000128">
        <property type="protein sequence ID" value="KAL1840085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="352" mass="39742" checksum="8EC50ED9903F56D3" modified="2025-10-08" version="1">MATDDRDVDSNQKLDENLLAALPEGGKVVSVKPSGQSDYCATYRIQVSLPGGTSQVFFAKEGTGAEGLGCIESAWSSEQATYSFIPEHVPRPIAKGTYKSNPDKHFFLAQFVDMIEDEIPRPEAYMGALAALHSRSMGKSPGGKFGFDVNTRFGNLEQDNAWTDSWEEFWTRQMSDYLAREAAIHSADPPHEELERLKPLFLEKVLPRYLRPLESDGRSVTPCLIHADLWPGNVKYMSDGDTVCVYDACCMWAHNEADLGVIRNPRYPLGKSYLKEYWKRVPISEPEEDADSRMIMYMMRSQILLSILYPRDLKLRDIFVANMRLLVERVEAEEAEKKGGTGKRMAAPQVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VEY1</accession>
    <name>A0ABR3VEY1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7791 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL1840420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7791"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7791" evidence="1">
        <location>
            <begin position="41"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="523" mass="58703" checksum="107F6DD11626EC79" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFA1</accession>
    <name>A0ABR3VFA1_HUMIN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="59"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="79"/>
            <end position="99"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL1840524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="99" mass="10647" checksum="0A360F5903991AF3" modified="2025-10-08" version="1">MATFVTLYQGPLSQTEGGRNQVPSAEEPHSVSRAEIPVPGELSSSNRHRANGASCARFSTGGRQECSAAAHETLIRQAPQIDPIELSRPHREPHSTVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="11">Plasma membrane channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_302</name>
    </gene>
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        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Mycothermus</taxon>
        </lineage>
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        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
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                <person name="Andreopoulos B."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
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                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000107">
        <property type="protein sequence ID" value="KAL1840570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="366"/>
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    </feature>
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        <location>
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            <end position="408"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="605"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="625"/>
            <end position="647"/>
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    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="18"/>
            <end position="147"/>
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    </feature>
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            <end position="661"/>
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            <begin position="485"/>
            <end position="504"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1840570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="82396" checksum="1710451C146E9300" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VFN3</accession>
    <name>A0ABR3VFN3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000111">
        <property type="protein sequence ID" value="KAL1840478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="864"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="891"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="99"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="537"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1840478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="103836" checksum="A106E23A09B2764C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGB9</accession>
    <name>A0ABR3VGB9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000095">
        <property type="protein sequence ID" value="KAL1840908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1840908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="547" mass="61662" checksum="2E9DA88BE0639D45" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGE3</accession>
    <name>A0ABR3VGE3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000094">
        <property type="protein sequence ID" value="KAL1840924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046774130" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="103" mass="10503" checksum="2CCFFE3E6DC69C77" modified="2025-10-08" version="1">MIPFKPLLLAVLAASTVLANPLPQTTDLEQCGPVVCAQGTTCCNPSCGICTPPGVACTMQACQPCGDTVCQLGTVCCNDSCGICAPPGEPCTTQLCQKLPPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGH6</accession>
    <name>A0ABR3VGH6_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000092">
        <property type="protein sequence ID" value="KAL1840968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1840968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="315" mass="34815" checksum="03756F58522AB55B" modified="2025-10-08" version="1">MNGINGGNMPGGMPPFPVPAGHQAELNYIYGMVEELSRQLAENQRTLEEVVAGVGRVRSRARAQSLGNDELIDAASDEIKAQEPNLDTLISILSEALDKAKFSRDANAALLSQYATVLATMLKQFHDYKARHVADVAAWHRSYRAQLAEARAENSRLREQMWEMQARAARANEMLRRFRQRYDEDAARWEKRVESRAVRQELRFWKRMAMPHLPDDDPYWSDDDDLVDPAEKKRLEELNRLAAEQQLAAAAELGDIMGGGGAEDGEVPPEAPAPPAIEQGMGMGGVPMQREDGGPVMLPIPPRPSSASSTGSSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGH9</accession>
    <name>A0ABR3VGH9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000109">
        <property type="protein sequence ID" value="KAL1840536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1840536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25718" checksum="02D89CDB42EF5A14" modified="2025-10-08" version="1">MVPSTRRSTRSSAGPVAGGKQTTLSFKHKVTKPVHHVGKEEKAAAEYKSPARAKEYIPDEEPATKRKRKSKDEEEEHEDEVEEEVKEEEAEEEEEEEEEEDNDVPVVKPQTPFDEAEARAAKLNDRAITQYWKDIEASRRAKEVHKRNTEGLSTAEKVLRYFDVSSQYGPCVGITRLKRWQRAQRLGLNPPIEVLAVLLKEEAKGNSDIEQAHMDVLLNSTAVGSVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VGR7</accession>
    <name>A0ABR3VGR7_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000088">
        <property type="protein sequence ID" value="KAL1841059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="415" mass="43291" checksum="E025779E3A828E94" modified="2025-10-08" version="1">MANYYDSSSSPWPAAGQQGWDHQTPPPARSGASSAIPREEPTAFLQQFEEVDRAIDNLVKSGKMFGGLGPRRESMPYPPGPARMYPVFPVDGRPPLGPGPRPHPAAPDFGDARGPHPGTNLQGFYATQRHQPSRGSNEAEQMMQAKRRMAAQRERDLRNYHQEQQYNRTVIADMTYGSAKPDRTMSPGSLPDEERRKLIAQQRSSLYGEGSFGDEAGATHPGLGGPQTGPAALRGHSPLAYEYGRAPPVHPDAGSQAEGAQVTPSAGPQEQARVNNSSPQSNPGSKGVYDAPAAQPASRTSASSPGGSPPRQGGAPGSKPTQSSVAPIGTRPSVSGPSSNPALNKRSTTPNLSSPLSQGYTAPKNDENTTPTTTAASNPPSATVEGGASVGLAGWGARPNGWGGKSGLGQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH04</accession>
    <name>A0ABR3VH04_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000085">
        <property type="protein sequence ID" value="KAL1841148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="169" mass="18686" checksum="618B6834CAE339FC" modified="2025-10-08" version="1">MVRPSRPTHAGIQALTKRRVQAPSHNLSPERVANFRAVFNIFDKDGTGDITADELGQVMRELGLNPTASELRDLVNEADLNNDGVISFEEFLALMSQSVNEPDTEQELLNAFKVFDKDGSGTISTEELRSVLKSLGENLTDAELDEMIQLADRDGDGQIDYAEFANIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VH62</accession>
    <name>A0ABR3VH62_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-classical export protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_7473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000089">
        <property type="protein sequence ID" value="KAL1841042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6544" checksum="A21B007A1930546C" modified="2025-10-08" version="1">MAAPVYIISRVVDPIFAVFIGVSAAALRINREEKEKGRTTQETIEALRRRIGYHLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHC4</accession>
    <name>A0ABR3VHC4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_7262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="399" mass="42729" checksum="112191E87CC29C72" modified="2025-10-08" version="1">MPFDQVRNRGDDIEEDTQQTAPPPPPAGSGAANPASSPSTTFSTTAAGAFPVQGKPLLPPLLHDLDQLLARLPSKIAFGLLHVDLEVDPNPSHGDSSNGRQLALPRRELWDVRVQLMAEDDDPSSSSAAAGESSESSEARAGLGQHDVKTGIYEGGFKSWESSVDMVKVLARERTVEGLLSRGPSVVVELGCGTALPSLALFTWALNHNTTPKHPLSLVLADYNPSVLYLVTLPNLILAWALQQRTANPLVAEAFTPDGELELTLELLAAFRSSLAEHHITFTFLSGAWSPEFVDLLYSALPADLPDTAATLVLGSETIYSPFALESFSATLFAMLQRERRDRPDGGARAVVAAKRLYFGVGGSLDDFVDRMRAMGAAVRTLAEETQGVHRGVVDCVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHJ9</accession>
    <name>A0ABR3VHJ9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000078">
        <property type="protein sequence ID" value="KAL1841350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="672" mass="75979" checksum="2D395C959FC3E5DE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VHL2</accession>
    <name>A0ABR3VHL2_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000081">
        <property type="protein sequence ID" value="KAL1841251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047208231" evidence="2">
        <location>
            <begin position="20"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="606" mass="64802" checksum="35E3387E97450AB2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI50</accession>
    <name>A0ABR3VI50_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_7093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1841416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="295" mass="30994" checksum="D6187E2C6D0A63E4" modified="2025-10-08" version="1">MAPTDHEGQFKFLLACIKHSAAGKVNFEEVAKETGIVSKAAAAKRYERLLKAHGISPSTPRKGKGANAKNEAAGSEENGSESAADAPSKTPASRKRKRTVAPRNKQPQTPARVEDESEDADADVDSPVKKEPKVKKETKIKKEPIAAVKKEEASDDDMADVKEESEGSSLHTVGFGNTAATATVTRFCSSGGVGVSTNGAGHDAKPAGKLVIPAEAVPMQDDDGDDACFIVGERVYYTCTNSNSSGELELATTASADNNITGCCVVVFGAVFVRGTSALVMKEIRAGRIQWVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VI89</accession>
    <name>A0ABR3VI89_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000071">
        <property type="protein sequence ID" value="KAL1841554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="945" mass="102994" checksum="D419B4A8A50B25E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VIV1</accession>
    <name>A0ABR3VIV1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_7083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000076">
        <property type="protein sequence ID" value="KAL1841406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1841406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="329" mass="37181" checksum="B40F4B0D98FD3448" modified="2025-10-08" version="1">MSDSIDRVFVHALNTVKKIPKTGAARPPPSDRMRLYGLYKQAMEGDVDGVMERPTASSVAVSGSASTSSEDLVREQDKWDAWNSQKGLSRTEAKRRYVETLIEIMHKYANTPNALELVAELEFVWNQVKSNNPSAAGSSSSSGQIGTSGRSERGEKTSLRGGHLSVGADRTQVVASPVTSPVIRRFQTPLSGTEGPMRVLRPMSEEDESERRLAELADQADDEPQSDYARRNDKRTKRMERAIVRLSAEIAALREQIAAREWRSRKEKGVIPWLGWLFWAVCKHVAVDLAILILLLLWMRKRKDRRFEDHVRGIFRLAREYIRKIVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJ63</accession>
    <name>A0ABR3VJ63_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_6511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000062">
        <property type="protein sequence ID" value="KAL1841834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="444"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="587"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1841834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="735" mass="81974" checksum="D3C41E02DF320427" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJF5</accession>
    <name>A0ABR3VJF5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_6190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000056">
        <property type="protein sequence ID" value="KAL1842024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26121">
        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="367"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1842024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="498" mass="54344" checksum="CE54CEECE658E92D" modified="2025-10-08" version="1">MPGVLRKTRATRSKLAPATPASTKPQTPAKETQISSPFGNRSSNIEIVLPSRKRKAHDEDAHSSKKLRGEQEQTQPPVPLTPVSRKRKSVRFADAEAEATPSTPVLAAVAPSTPTSRKRRFDADDTSPEALLSRLQLQSPTATTLKKKKTTPDRRAPLTDFDLPRELNDLLDMHAAFLKTLTMQCAHTTSGAPIDLRDLYDSITRAWGKRHVNIDDIRRCIGVLSWTPAKTDKTSSRPSPAVPYYLADYGRDKICIEFHKSVDRQYADGGLLRVPKLNMDFETNLRTLWLSRSHNMPGAVFIGTLPKAPIKPCAAASKVGPLASKTTQTTLDAFKRDLAEKKAQQQAKQQATTTTTTTPSSSTPQLSLLERIRLKESLLSQQQTSEDSSAASARRRALQRCPDVAAVITMLCKAGASGPVTQARVSFTMTALLARLRDSMASALGNEEAAQCVRLLASEVAPQWLRVVKVGGRENVVVTVAGQMAKGMVEEKVKALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJG2</accession>
    <name>A0ABR3VJG2_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_6954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000072">
        <property type="protein sequence ID" value="KAL1841525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1841525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="299" mass="32714" checksum="015865A9E8453061" modified="2025-10-08" version="1">MSTNAQYVPTYSPCPPLDEQGEWVWALPANPHYSPMMNRSPSSDSHSSGAYDSTTMSYTQSPLTPLSPEFSDFSTGPNGTPATSPAMDVLDPDLDAFLASYLTDDASQSQSWSVPEQNPAVTAASLELCSSFDADLFPVLDFPLALDTTDLLTPPGPAVCPQPVFPTPAVTTTTSTFLPPPQPQPLPQQQQQQQQQESLACPEPTCHRTFPTRQDLRKHERTHRPSAPCPVCPKRQLDNRALARHLWAQHPEEAKRLGVPSETARCPWPGCKYEGRRDNVKRHMKRHASSGPCSGAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJH8</accession>
    <name>A0ABR3VJH8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartokinase</fullName>
            <ecNumber evidence="6">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">VTJ49DRAFT_6118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="6"/>
    <dbReference type="EMBL" id="JAZGSY010000055">
        <property type="protein sequence ID" value="KAL1842048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="461"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1842048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="524" mass="57056" checksum="DB1F0DC6037CDA52" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJP3</accession>
    <name>A0ABR3VJP3_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_6910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000070">
        <property type="protein sequence ID" value="KAL1841600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1841600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="256" mass="27399" checksum="BBD9217049EA6273" modified="2025-10-08" version="1">MTAVESRKTLRVGVFALPDTQLLDLACVDVLASMSYEYFSLLGEFIPASILALAPSMQISYISTLQPGSFIPLTAQVKVPCTHHFSDPAVAPGQLDVILVPGPDPALDFSAFKDATSWLAAHAARPETDILSICTGILIVGEAGILKGKKACGPRGMQDELTKRFEGVKWVGEELRWVRDGNVWSSGGITNGNDLVGAYARLSGRIPGPVAETGLILTDTGDRPQRYETGKMVWMLGIVWQTLKAAVMGLGKKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VJV9</accession>
    <name>A0ABR3VJV9_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_6759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000068">
        <property type="protein sequence ID" value="KAL1841653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1841653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="623" mass="69699" checksum="F91E1BD19C495B0E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK21</accession>
    <name>A0ABR3VK21_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">VTJ49DRAFT_6074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000054">
        <property type="protein sequence ID" value="KAL1842092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="276"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="660"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="368"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL1842092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="708" mass="78170" checksum="8E12D37F681C8B47" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK48</accession>
    <name>A0ABR3VK48_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">VTJ49DRAFT_5829</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="482"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="325"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL1842217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="604" mass="66804" checksum="1142F325CAB9FC80" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VK50</accession>
    <name>A0ABR3VK50_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Histone deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_5664</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 8"/>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="83"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1842279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="498" mass="56543" checksum="D7BF409DB2CBB171" modified="2025-10-08" version="1">MDENAYRYRPPRPNYLPHDIHVNNPIVEEYTIPLGPADDHENAAYFNKMKIAAQEYGIVRPKGYTVSYHATPEMEKHHFGQTHPMKPWRLTLTKSLVTAYGMPFAMDNYLTREATYEELNAFHSSDYLDYLIAAEPEDQPRDIDNPDKEVKYNLGGSDCPLFHGLYNYCSMSAGCSLDAARKIVAHQSDIAIAWGGGLHHAKRYEASGFCYINDIVLAILELLRIYPRVLYIDIDVHHGDGVEEAFFSTDRVMTVSFHKYQPEQFFPGTGALEDNGPKNEHNPGAHHAINVPLQDGITDEQYEALFKNIIGPINERYRPSAIALQCGADSLAGDRLGRFNLRVQGHGACVKYCKSLGLPMIIFGGGGYTPRNVARAWAYETSIAIGADDRIPETIPEHAPWRAHFIHDTLFPSLEQSMHEPRHNRNSEKRLREIVAHVHEQLRFVQHAPSVQSTIIPPNLEPVRDEVEARMKEEAEERERNEIARKTREEGIGQAMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKD7</accession>
    <name>A0ABR3VKD7_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000052">
        <property type="protein sequence ID" value="KAL1842158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="L30e-like"/>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="122"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="292" mass="32348" checksum="BF26251510E02461" modified="2025-10-08" version="1">MAATDKVDIVDDKKAKKEKKEKKDKSEKKDKSDKKDKKRSDDGGIRKEKKDKKKDKAKQEKLARALDAHLQADAAAQAEKSLVAATVDADVSIADADPEDIIKPAEELVPFALPLADEKTHKKIYKLIKKGAKLKSIHRGVKECEKAIKKCPVKTAAQATDGPVPGLVIIAADISPMDVIMHFPILCEEHGVPYLYVKSRADLGVAACTKRATSVVMLKPEGKKPNNNNNDKKKDEDKDDDVEMTRDEYLAAWKELVSTAEKEWKTQVQPWVKGTHPLQVAAREEARRAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKF0</accession>
    <name>A0ABR3VKF0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA (cytosine-5-)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000050">
        <property type="protein sequence ID" value="KAL1842212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1266"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1289" mass="139985" checksum="7D579F82A66D9A82" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VKG0</accession>
    <name>A0ABR3VKG0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_5655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000048">
        <property type="protein sequence ID" value="KAL1842270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="481"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="944"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1757"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="954"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1842270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1776" mass="197972" checksum="2BB11FCDCE8588C5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VL23</accession>
    <name>A0ABR3VL23_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_5115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
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                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000041">
        <property type="protein sequence ID" value="KAL1842509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1842509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="261" mass="28404" checksum="4DA52D75CEF9F4AD" modified="2025-10-08" version="1">MAELSMEVQCASCGDHPGPSSSKGKGKAVSFAPQSGHSGGSRASGKPKLASVPEDEITPAEPGPSSPSSIVSLAEDIDMPLTATIEIAVVGLQFVGKTAMIAKFLDRNYNLQHQPPIIGERPMQVKGLVKENKRYNLMIKDVTGAVLNLYPNCHFLQEMQGVILTFDLTKRGTFTGVEGWWRHANLVFPEMPFCVVVGNKCDQAQEREVTPEEGEQLAQRLGGLFFCETSAMTGEHIRRPFVGLLRRIVPTLGPLEIEDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VLF4</accession>
    <name>A0ABR3VLF4_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="14">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">VTJ49DRAFT_4368</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="14"/>
    <dbReference type="EMBL" id="JAZGSY010000034">
        <property type="protein sequence ID" value="KAL1842730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1097"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1134"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1177"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1209"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="228"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="322"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1026"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL1842730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="1354" mass="151001" checksum="3D515ACDC82B5715" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMI0</accession>
    <name>A0ABR3VMI0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_3219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="266"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="895"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="948" mass="104918" checksum="B930E5D8EAF46EF5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VMX0</accession>
    <name>A0ABR3VMX0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_3217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="104"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="332" mass="36054" checksum="B64E8393D1C1DB11" modified="2025-10-08" version="1">MASPNPNSPEEEETSYVKMSTAAVDSRGTDASLVGSHCQYAYCNQLDFLPFRCQSCNKTFCLEHRTEDGHECTQKGAWAARKREAELARHGAGAGHRMRDPVTGHRPRPCAADDCKTTVGTSLHPGVHCDKCNRAYCLKHRLREDHDCANKPPIGARATSAAEAATAAAEGARSALEKFRLWGLAKKQKAKESLASASVSVGGAKKQSNAARLVAVNSLKKTAKGDAKLAPEKRVYLYVEAEATTTRSKIPKGEFFYSREWKVGKLLDAAAKSLQVPNLNNQSNAEEDRLRVFHVEGGRLLEFNEVVGDVLQSGNTVVLLRGVGPPPDLIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN84</accession>
    <name>A0ABR3VN84_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">VTJ49DRAFT_1961</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000018">
        <property type="protein sequence ID" value="KAL1843374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="9">
        <location>
            <begin position="59"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="10">
        <location>
            <begin position="398"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="8">
        <location>
            <begin position="576"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="8">
        <location>
            <begin position="830"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="755"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL1843374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="924" mass="103446" checksum="0AD71099D3821E47" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VN85</accession>
    <name>A0ABR3VN85_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_3184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000025">
        <property type="protein sequence ID" value="KAL1843049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="297"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="714" mass="79888" checksum="3CBB21DCAB2EAAD8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VNC9</accession>
    <name>A0ABR3VNC9_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23852" checksum="440C91AF43A31C26" modified="2025-10-08" version="1">MASKFTREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCIVDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRESFEEIRTFQQQILRVKDKDAFPMVVVGNKLDLAHERKVSVEEGKALADEFKCRFLETSAKTNTNVEQAFYEVVRAIRRYNREMQGGPAGGSGLSHNGGGMNKMDIADDDAQGGCCAKCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VP24</accession>
    <name>A0ABR3VP24_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_2136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000019">
        <property type="protein sequence ID" value="KAL1843319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD synthase middle" evidence="2">
        <location>
            <begin position="195"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="300" mass="33149" checksum="98B0815E4D5679BD" modified="2025-10-08" version="1">MKTASENAARTIHTAACLIIGDETKDTNSHCFAKWCFDLGIRRHRADVSQPSSPLTLLAKLTFHPAPLTSHDDITYQSIAKAFGLPLVLHQQAFELMKKLSRQHPGQPNFRWDEDSPALRAKLRMVEIPTDPSRSLAEQAVFPCEDAWVPVAIVNGNVHILPGVPKLFEKLLQGLTPRILPRLSDPRGKGIVRVSISTPMPESAIAAYLTELAARVQSRGVKVGSYPRWGKTRNTVTLVGRDQEFLNSIAPEVAQAVNGKVVQTEGEDDDESEKDKDKEEEDAAKEGKAEAKPHEADKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPA8</accession>
    <name>A0ABR3VPA8_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="8">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="8">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BNA1</name>
        <name evidence="9" type="ORF">VTJ49DRAFT_124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="8"/>
    <dbReference type="EMBL" id="JAZGSY010000010">
        <property type="protein sequence ID" value="KAL1843743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL1843743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="182" mass="20980" checksum="1042316F18E2FB98" modified="2025-10-08" version="1">MLAPPVNLPKWLEENSHLLKPPINNYCVYNEDFTVMIVGGPNARTDYHINQTPEWFYQYKGAMLLKVVDDGQFRDIIIREGDMFLLPSNTPHNPVRFADTVGIVLEQRRPEGSLDRMRWYCAREDCRAVVHEAAFHCTDLGTQIKEAVEKFKADEEARRCKKCGEVADWCPKPGSIRDPNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPK5</accession>
    <name>A0ABR3VPK5_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_7191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000008">
        <property type="protein sequence ID" value="KAL1843840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF242">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="92"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1843840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="335" mass="36656" checksum="3A9C675A3407F2BA" modified="2025-10-08" version="1">MTASGVAKAAGIWAGGLLLGLGLPHLPHLSSSPLTSLIGGFPLADYPFAIPFLKPSANKLNTTTPASNATTPAPFVCDTTHSYTTELVSLDPLIIYIHNLITPSEITSLLETAEPRFAPSRVAKYGRVTSTSDRTSVSAGLPREDPAVQCVLGRARQFLGTMLRDGWDEMGAPQLVRYETGQHFNLHHDWFSVPQWPTRPDDTRKWNRVASFFAILEDNCTAGETYFPDAKPIVRKAPWGAGLWQGKREVVKVVKEEGEEGEGGEKGEASVELSPPLWREHEDGGLAFRPVAGNAIFWVNLHPNGTGDMRTMHAGLPLESGRKTAMNIWPRQYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VPN6</accession>
    <name>A0ABR3VPN6_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">VTJ49DRAFT_3699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000029">
        <property type="protein sequence ID" value="KAL1842911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL1842911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="53207" checksum="53F31FA108F41DB8" modified="2025-10-08" version="1">MAGNSRQWQREAGAGFDKEKTREGSCSDDGVVAETVDNVAIEMDAVTSRGTGPAAADPGSEPTALPSACETEYRVYKRRWFGLLQLTLLNIIVSWDWLTFAPVASHAARYFDTTETVVNWLSTSFMFAFTFATPAVIYLLHLGPKPSIATSAGLVLVGNWIRYAGAHSTSGGIFGVVMFGQILTGFAQALVLPAPARYSDLWFTHRGRVAATAFSSLANPLGGALGQLIVPFWVNQPSDVPRMVLYMSIISSVCAIPAFFIPAKPPSPAAPSSETPKLSLRSSAAALAGQLEFWLLAFPFAVYVGLFNSLSSLINQILLPYGFNDEEAGIAGALLIAVGLVAAAVSSPIIDRTKSFLAAVRTAVPLIAASYLAFVWMPATRSVAGPYVVMAILGAASFSLVPVAVEYLVELTHPVSPAVTSTLAWSSGQLLGGVFIIVAGALKAGEDGDPPGNMYDALVFHAVLAMVAAVPPLCLGLFGRGDKLLLRRVRSDEGSGRSSVEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQ73</accession>
    <name>A0ABR3VQ73_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">VTJ49DRAFT_607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Post-SET" evidence="4">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL1843625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="270" mass="29405" checksum="AA713A510EE8A5C6" modified="2025-10-08" version="1">MAPLTPHWVQPSHPDIQEVIVTGNAAEFTTKSVSKITLPPFGLFAKLDFPPCTEAPEPTYATVQMGRDRHLNLNSDLLYINHSCEPSLIFDMAAMNIIAGPKGLKPGDELTFFYPSTEWYMAQPFDCLCGTSSCRGRIAGARDMTPTQLEGMWLNRHIRDLLEERDQQQQQQTKTVANGTHGNTANGSSPTQQQQALRSALAQAEKLIETLRQAADGLDSASASGSLKRKRVAEDGFIDDDSPCEPAGLQRRGPTSRELSGEMGGDTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQG4</accession>
    <name>A0ABR3VQG4_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">VTJ49DRAFT_6401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000006">
        <property type="protein sequence ID" value="KAL1843997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL1843997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="333" mass="37332" checksum="F85F616166FEE80C" modified="2025-10-08" version="1">MLRLDRDQECYDFIKWWAHVPGSYDFGDASRPYLDTRDADVFEPLSVVLTRFQSLSHLVSLTLLKLRLYHDLKAVLGMSDQGVRDWLNTTKKQYHELIEAVHKANPHFWEVFVDDGSDGLPEIYGLGSKEEALLVKEWCTKSWQESGNAYAIIEADTTHLVSVYQGTSTPSPTAAPTTGRPTPIVALCVDYPELVNDVYKGIISRITSKVQMDQATTPEKALELLGKTPRPPVILVADSHIGRNNKVLESVADCLYAGSTVILCGCFSTMISEGQFTRMFTRLGLPWRRGSYTRETTKLWPGPRSALAGLGRCKPFLICARPRSREEYGQAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VQN0</accession>
    <name>A0ABR3VQN0_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_4967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000004">
        <property type="protein sequence ID" value="KAL1844115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL1844115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="107" mass="11514" checksum="2982C982BF48B2DE" modified="2025-10-08" version="1">MPDFHASANDIHVDDGHILRAILTSADGHQVEASCDLDDYIGNTNGHFEWNGMDFSKSAQDITLAAEGDASLPVLRASLRNAKGELIPASINLAEHISNIDGALRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR10</accession>
    <name>A0ABR3VR10_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-tryptophan decarboxylase PsiD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">VTJ49DRAFT_886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000013">
        <property type="protein sequence ID" value="KAL1843603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="5">
        <location>
            <begin position="429"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL1843603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="825" mass="92215" checksum="E776F39B6CFF70CE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VR18</accession>
    <name>A0ABR3VR18_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">VTJ49DRAFT_600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000012">
        <property type="protein sequence ID" value="KAL1843618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="647"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL1843618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="913" mass="98351" checksum="8517293983F28F71" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRV1</accession>
    <name>A0ABR3VRV1_HUMIN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">VTJ49DRAFT_68</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001583172">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="137"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL1844389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001583172"/>
        </source>
    </evidence>
    <sequence length="288" mass="32705" checksum="8DA3A8FDAA88113C" modified="2025-10-08" version="1">MSNPTPAQEEFAAFLDKNTRSSLDRIHPEDRDDAAREEEENSEDEEDRYLAQQIDAAMRMPTMDSRTEIRLPPADFDRGCSTGVKGVIADARSYEAARRSKWKDRVRAARRSVFGFDSARSNRSSDHDSDGSALEDPDEAAFLQQWRESRRRELEQESKNPVRNRRTSPSVRLFGRFDQVDALGYLDAIEKVGRETVVVVFVYDHECDVSAAIESALVPLVTSYPAVRFVKVHYEDIEFDNAGVPAILAYRNQGDLFANLTGILEMIPDDEDFDTDSLKELFIKQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3VRW3</accession>
    <name>A0ABR3VRW3_HUMIN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">VTJ49DRAFT_74</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Humicola insolens</name>
        <name type="common">Soft-rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="85995"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Mycothermus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="0" last="0">
            <title>Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses.</title>
            <authorList>
                <person name="Steindorff A.S."/>
                <person name="Aguilar-Pontes M.V."/>
                <person name="Robinson A.J."/>
                <person name="Andreopoulos B."/>
                <person name="LaButti K."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Otillar R."/>
                <person name="Haridas S."/>
                <person name="Lipzen A."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Clum A."/>
                <person name="Reid I.D."/>
                <person name="Moisan M.C."/>
                <person name="Butler G."/>
                <person name="Nguyen T.T.M."/>
                <person name="Dewar K."/>
                <person name="Conant G."/>
                <person name="Drula E."/>
                <person name="Henrissat B."/>
                <person name="Hansel C."/>
                <person name="Singer S."/>
                <person name="Hutchinson M.I."/>
                <person name="de Vries R.P."/>
                <person name="Natvig D.O."/>
                <person name="Powell A.J."/>
                <person name="Tsang A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="39266695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 620.91</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAZGSY010000001">
        <property type="protein sequence ID" value="KAL1844395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Prote